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TADA1L Gene

protein-coding   GIFtS: 46

GC01M165092
transcriptional adaptor 1 (HFI1 homolog, yeast)-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000032213 2
RP1-9E21.4 2
STAF42 1, 2, 3, 5
Descriptions
SPT3-associated factor 42 3
SPT3-associated factor 42 (STAF42) 2
transcriptional adaptor 1 (HFI1 homolog, yeast)-like 2
transcriptional adaptor 1-like 2
External Ids
HGNC: 306311
Entrez Gene: 1171432
UniProtKB: Q96BN23
Ensembl: ENSG000001523827
Search outside databases for aliases for TADA1L gene

Previous GC identifer: GC01M163558

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TADA1L:
TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5
(MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex
(Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM]

UniProtKB/Swiss-Prot: TAD1L_HUMAN, Q96BN2
Function: Probably involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TADA1L gene  

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.1

TADA1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165092:     (about GC identifiers)

Start:
165,092,371 bp from pter
End:
165,112,103 bp from pter
Size:
19,733 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAD1L_HUMAN, Q96BN2 (See protein sequence)
Recommended Name: Transcriptional adapter 1-like protein  
Size: 335 amino acids; 37382 Da
Subunit: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H,
GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Subcellular location: Nucleus

REFSEQ proteins: NP_444281.1  

ENSEMBL proteins: 
ENSP00000356848 


Human Recombinant Proteins 
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Human Recombinant Proteins from Abnova (TADA1L)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for TADA1L: 
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Assays for TADA1L: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96BN2

UniProtKB/Swiss-Prot: TAD1L_HUMAN, Q96BN2
Similarity: Belongs to the TADA1L family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TADA1L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053053

              Applied Biosystems Silencer® siRNAs for TADA1L

              Sigma-Aldrich siRNA for TADA1L  
                     Sigma-Aldrich shRNA for TADA1L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for TADA1L
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053053
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053053
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_053053 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_053053

UniProtKB/Swiss-Prot: TAD1L_HUMAN, Q96BN2
Function: Probably involved in transcriptional regulation

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TADA1L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TADA1L)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053053

              Sigma-Aldrich siRNA for TADA1L  
                     Sigma-Aldrich shRNA for TADA1L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_053053  

REFSEQ mRNAs for TADA1L gene: 

NM_053053.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_053053  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053053
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053053
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_053053 

Additional cDNA sequence: 

AK097234.1 AK290964.1 AK291922.1 AK309250.1 AK310391.1 BC015401.2 BC036497.1 CR618254.1 
CR619512.1 

9 DOTS entries:

DT.100021883  DT.95072415  DT.435782  DT.95271895  DT.100712859  DT.121329968  DT.40197294  DT.95319337 
DT.121329971 

24/149 AceView cDNA sequences (see all 149 ):

R23855 BQ007595 CR618254 AI638273 F02843 AI091145 BU506795 BQ692025 
BC015401 AV695196 CB215701 BG530033 T32678 AW006271 CB156261 BM802734 
Z40141 AI620275 CA487312 AL521142 BM465890 BQ433949 NM_053053 BQ686349 

highest scoring ESTs for TADA1L:

AL703168 AL703355 AV647292 AV760041 BC015401 BE165279 BF338443 BF528015 BF665270 BF976915 

Unigene Cluster for TADA1L:

Transcriptional adaptor 1 (HFI1 homolog, yeast)-like
Hs.435967  [show with all ESTs]
Unigene Representative Sequence: BC036497


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TADA1L

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1:              -                       -     -                                 
SP2:              -     -     -           -     -                                 
SP3:              -                                                               
SP4:                                                                              
SP5:                                                                              

About this scheme

ECgene alternative splicing isoforms for TADA1L

1 Ensembl transcript including schematic representation:
ENST00000367874  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TADA1L expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TADA1L

1 / 2 / 3

3 probe-sets matching TADA1L gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
48082_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA115333 0.60 1.00 0.82 1

225455_at2, 3 U133-B 1 1.00 1.00 -- -- AI760812 0.40 1.00 0.76 1

225455_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  TADA1L for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACTCAAGTTT

SOURCE GeneReport for Unigene cluster: Hs.435967
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TADA1L gene from 5/11 species (see all 11 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TADA1L1   -- transcriptional adaptor 1 (HFI1 homolog, yeast)-like 92.84(n)
98.51(a)
480090  XM_537213.2  XP_537213.2 
chimpanzee
(Pan troglodytes)
TADA1L1   -- transcriptional adaptor 1 (HFI1 homolog, yeast)-like 99.7(n)
100(a)
457482  XM_513967.2  XP_513967.1 
cow
(Bos taurus)
TADA1L1   -- transcriptional adaptor 1 (HFI1 homolog, yeast)-like 92.04(n)
97.31(a)
521918  XM_865208.2  XP_870301.1 
rat
(Rattus norvegicus)
Tada1l1   -- transcriptional adaptor 1 (HFI1 homolog, yeast) like 89.75(n)
96.72(a)
360874  XM_001063180.1  XP_001063180.1 
mouse
(Mus musculus)
Tada1l1, 5 1 (86.60 cM)5
transcriptional adaptor 1 (HFI1 homolog, yeast) like1, 5 89.55(n)1
95.82(a)1
278781  NM_030245.21  NP_084521.11 
 AI4139405  AK0135995  (see all 21)
About this table        Species with no ortholog for TADA1L

ENSEMBL Gene Tree for TADA1L
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/116 NCBI SNPs in TADA1L are shown (see all 116 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 49)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs22809951,2
A,C,F,H165112693(+) AAATGA/GGGTAA 1 -- ng313Minor allele frequency- G:0.37EU EA 298
--
rs67181,2
A,C,F,H165092461(-) AATGGT/CTGTAT 1 -- ut319Minor allele frequency- C:0.44MN NA EU EA WA 912
--
rs66750331,2
A,C,F,H165093279(+) CACAAC/TAGCAA 1 -- ut31 ese34Minor allele frequency- T:0.31EU EA WA 400
--
rs22727921,2
C,F,H165096146(+) GTAACC/TGATAA 1 R/Q mis1 ese313Minor allele frequency- T:0.10EA NA EU WA 2534
--
rs109185891,2
A,C165113102(+) CCACAA/CATAGA 1 -- ng310--------
rs66751531,2
A,C165093397(+) GAATTC/TGGTGA 1 -- ut31 ese30--------
rs115872461,2
C165112187(+) GGAAGA/CTAAGC 1 -- ut51 ese30--------
rs7605371,2
A,C,F,H,O165098496(+) TTTGCG/ATAGTA 1 -- int115Minor allele frequency- A:0.39NA EA MN EU WA 1401
rs20499091,2
A,C,F,H,O165098569(+) CTGAAG/AGAGAA 1 -- int1 trp37Minor allele frequency- A:0.07EU EA WA NA 550
rs14763491,2
A,C,F,H,O165099078(+) ATCCCA/GATGGC 1 -- int17Minor allele frequency- G:0.36NA EU EA WA 546
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HapMap Linkage Disequilibrium images for TADA1L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612763

Human Genome Epidemiology Navigator: TADA1L (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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8 PubMed articles for TADA1L gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 117143 HGNC: 30631 AceView: STAF42 Ensembl:ENSG00000152382 euGenes: HUgn117143
ECgene: TADA1L H-InvDB: TADA1L
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TADA1L:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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