TADA1 Gene
protein-coding GIFtS: 45
GCID: GC01M166826
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|
transcriptional adaptor 1(Previous names: transcriptional adaptor 1 (HFI1 homolog, yeast)-like, transcriptional...) (Previous symbol: TADA1L)
| |
Aliases for TADA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transcriptional Adaptor 11 2 | | Transcriptional Adapter 1-Like Protein2 3 | | STAF421 2 3 5 | | Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)-Like1 | | TADA1L1 2 3 5 | | RP1-9E21.42 | | ADA11 2 | | SPT3-Associated Factor 42 (STAF42)2 | | HFI11 2 | | Transcriptional Adapter 12 | | HADA11 | | SPT3-Associated Factor 423 | | Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)1 2 | | |
Export aliases for TADA1 gene to outside databasesPrevious GC identifers: GC01M165093 GC01M138072 |
Summaries for TADA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TADA1: TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301)acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 (PubMed11564863)).(supplied by OMIM, Apr 2009) UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2Function: Probably involved in transcriptional regulation
|
Genomic Views for TADA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TADA1 Other transcription factors
Search SABiosciences Chromatin IP Primers for TADA1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TADA1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24.1 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q24.1TADA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M166826: view genomic region
(about GC identifiers)
Start:
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166,825,747 bp from pter |
End:
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166,845,654 bp from pter |
Size:
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19,908 bases |
Orientation:
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minus strand |
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Proteins for TADA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2 (See
protein sequence)Recommended Name: Transcriptional adapter 1 Size: 335 amino acids; 37382 Da
Subunit: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L,TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for TADA1: NX_Q96BN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BN2 TADA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444281.1 ENSEMBL proteins: ENSP00000356848 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TADA1 for ontologies About GeneDecksing
TADA1 Antibody Products: Assay Products for TADA1: |
Protein
Domains / Families for TADA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TADA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96BN2ProtoNet protein and cluster: Q96BN2 UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2Similarity: Belongs to the TADA1 family |
Function for TADA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2Function: Probably involved in transcriptional regulation
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TADA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TADA1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TADA1 (NM_053053) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TADA1 for ontologies About GeneDecksing
|
Pathways & Interactions for TADA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TADA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/26 Interacting proteins for TADA1 (Q96BN23 ENSP000003568484) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TADA1 for ontologies About GeneDecksing
|
Drugs & Compounds for TADA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TADA1 Search CenterWatch for drugs/clinical trials and news about TADA1 
|
Transcripts for TADA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TADA1 gene: NM_053053.3 Unigene Cluster for TADA1: Transcriptional adaptor 1 Hs.435967 [show with all ESTs]Unigene Representative Sequence: BC0364972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467021(uc001gdv.3) ENST00000367874(uc001gdw.3 uc009wve.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TADA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TADA1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TADA1 (NM_053053) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TADA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA1  |
Additional cDNA sequence: AK097234.1 AK290964.1 AK291922.1 AK309250.1 AK310391.1 BC015401.2 BC036497.1 9 DOTS entries: DT.100021883 DT.95072415 DT.95271895 DT.435782 DT.100712859 DT.121329968 DT.40197294 DT.95319337 DT.121329971 24/149 AceView cDNA sequences (see all 149): CR618254 BQ007595 CR619512 BC015401 BQ433949 BM465890 NM_053053 AL521142 AV695196 R23855 BU506795 BQ692025 BQ686349 AI091145 Z40141 CB156261 T32678 CB215701 BP378606 AW006271 AI378849 CA487312 AI620275 BG530033 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TADA1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | |
| SP1: | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TADA1
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Expression for TADA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TADA1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ACTCAAGTTT
About this image See TADA1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TADA1
SOURCE GeneReport for Unigene cluster: Hs.435967 SABiosciences Custom PCR Arrays for TADA1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TADA1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TADA1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TADA1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TADA1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA1 |
Orthologs for TADA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TADA1 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Tada11 , 5 |
transcriptional adaptor 11, 5 |
89.15(n)1 95.82(a)1 |
  |
1 (73.74 cM)5 278781 NM_030245.31 NP_084521.11 1663790975 |
chicken (Gallus gallus) |
Aves |
TADA1L1 |
transcriptional adaptor 1 (HFI1 homolog, yeast)-like |
80.2(n) 91.04(a) |
  |
769871 NM_001197036.1 NP_001183965.1 |
lizard (Anolis carolinensis) |
Reptilia |
TADA16 |
-- |
83(a) |
1 ↔ 1 |
4(71267257-71273314) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.183502 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.79(n) |
  |
BQ729213.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.269092 |
Danio rerio SPT3-associated factor 42 (STAF42) mRNA, more |
71.78(n) |
  |
AY423005.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Ada1-21 |
Ada1 |
44.77(n) 33.94(a) |
  |
318992 NM_164980.1 NP_723703.1 |
ENSEMBL Gene Tree for TADA1 (if available) TreeFam Gene Tree for TADA1 (if available)  |
Paralogs for TADA1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TADA1 gene
TADA1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TADA1 PGOHUM00000249538
|
Genomic Variants for TADA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TADA1 (166825747 - 166845654 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TADA1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TADA1 |
|
Disorders
/ Diseases for TADA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TADA1 for disorders About GeneDecksing
OMIM gene information: 612763
OMIM disorders: --
10 diseases for TADA1: About MalaCardstuberculous empyema severe combined immunodeficiency pleural tuberculosis combined immunodeficiency essential hypertension hypertension t-cell leukemia tuberculosis leukemia immunodeficiency 2 diseases from the University of Copenhagen DISEASES database for TADA1:Tuberculous empyema Tuberculosis Human Genome Epidemiology (HuGE) Navigator: TADA1 (0 documents) Export disorders for TADA1 gene to outside databases
|
Publications for TADA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TADA1 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with TADA1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2, 3 Martinez E.... Roeder R.G. (2001)
- GCN5 acetylates and regulates the stability of the onc oprotein E2A-PBX1 in acute lymphoblastic leukemia. (PubMed id 23044487)1 Holmlund T....Wallberg A.E. (2013)
- Effect of ADA1 mother-fetus and wife-husband phenotypi c differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA. (PubMed id 22287124)1 Gloria-Bottini F....Magrini A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A Myc network accounts for similarities between embry onic stem and cancer cell transcription programs. (PubMed id 20946988)1 Kim J....Orkin S.H. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
- Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (2009)
- Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. (PubMed id 18250150)1 Gamper A.M. and Roeder R.G. (2008)
|
External Searches for TADA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TADA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TADA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TADA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TADA1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TADA1 gene: Search GeneIP for patents involving TADA1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TADA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | TADA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA1 |
|  |  |  | | | Search ThermoFisher Antibodies for TADA1 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA1 |
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