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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TADA1 Gene

protein-coding   GIFtS: 45
GCID: GC01M166826

transcriptional adaptor 1

(Previous names: transcriptional adaptor 1 (HFI1 homolog, yeast)-like, transcriptional...)
(Previous symbol: TADA1L)
 Explore 10 diseases affiliated with
TADA1 via our new
 Human Malady Compendium 
Biological research products
for TADA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transcriptional Adaptor 11 2     Transcriptional Adapter 1-Like Protein2 3
STAF421 2 3 5     Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)-Like1
TADA1L1 2 3 5     RP1-9E21.42
ADA11 2     SPT3-Associated Factor 42 (STAF42)2
HFI11 2     Transcriptional Adapter 12
HADA11     SPT3-Associated Factor 423
Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)1 2     

External Ids:    HGNC: 306311   Entrez Gene: 1171432   Ensembl: ENSG000001523827   OMIM: 6127635   UniProtKB: Q96BN23   

Export aliases for TADA1 gene to outside databases

Previous GC identifers: GC01M165093 GC01M138072


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TADA1:
TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301)
acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 (PubMed
11564863)).(supplied by OMIM, Apr 2009)

UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2
Function: Probably involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TADA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTADA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TADA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TADA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q24.1

TADA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TADA1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M166826:  view genomic region     (about GC identifiers)

Start:
166,825,747 bp from pter      End:
166,845,654 bp from pter
Size:
19,908 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2 (See protein sequence)
Recommended Name: Transcriptional adapter 1  
Size: 335 amino acids; 37382 Da
Subunit: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L,
TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for TADA1: NX_Q96BN2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BN2

  • TADA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_444281.1  
    ENSEMBL proteins: 
     ENSP00000356848  

    Human Recombinant Protein Products: 
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    Uscn Proteins for TADA1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030914STAGA complex IDA11564863


    TADA1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TADA1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024738 Hfi1/Tada1

    Graphical View of Domain Structure for InterPro Entry Q96BN2

    ProtoNet protein and cluster: Q96BN2

    UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2
    Similarity: Belongs to the TADA1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TADA1_HUMAN, Q96BN2
    Function: Probably involved in transcriptional regulation

    miRNA
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    hsa-miR-548j hsa-miR-2052 hsa-miR-548i hsa-miR-548k hsa-miR-200a hsa-miR-548l hsa-miR-141 hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidTADA1 3' UTR sequence
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863


    TADA1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TADA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for TADA1 (Q96BN23 ENSP000003568484) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000002178934I2D: score=1 STRING: ENSP00000370201 STRING: ENSP00000217893
    KAT2AQ928303, ENSP000002259164I2D: score=3 STRING: ENSP00000225916
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    SUPT3HO754863, ENSP000003605154I2D: score=1 STRING: ENSP00000360515
    TAF10Q129623, ENSP000002994244I2D: score=1 STRING: ENSP00000299424
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0043966histone H3 acetylation IDA11564863


    TADA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TADA1
    Search CenterWatch for drugs/clinical trials and news about TADA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TADA1 gene: 
    NM_053053.3  

    Unigene Cluster for TADA1:

    Transcriptional adaptor 1
    Hs.435967  [show with all ESTs]
    Unigene Representative Sequence: BC036497
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467021(uc001gdv.3) ENST00000367874(uc001gdw.3 uc009wve.2)


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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TADA1 (see all 29):
    hsa-miR-548j hsa-miR-2052 hsa-miR-548i hsa-miR-548k hsa-miR-200a hsa-miR-548l hsa-miR-141 hsa-miR-629*
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK097234.1 AK290964.1 AK291922.1 AK309250.1 AK310391.1 BC015401.2 BC036497.1 

    9 DOTS entries:

    DT.100021883  DT.95072415  DT.95271895  DT.435782  DT.100712859  DT.121329968  DT.40197294  DT.95319337 
    DT.121329971 

    24/149 AceView cDNA sequences (see all 149):

    CR618254 BQ007595 CR619512 BC015401 BQ433949 BM465890 NM_053053 AL521142 
    AV695196 R23855 BU506795 BQ692025 BQ686349 AI091145 Z40141 CB156261 
    T32678 CB215701 BP378606 AW006271 AI378849 CA487312 AI620275 BG530033 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TADA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:              -                       -     -                                 
    SP2:              -     -     -           -     -                                 
    SP3:              -                                                               
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for TADA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TADA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCAAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TADA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TADA1

    SOURCE GeneReport for Unigene cluster: Hs.435967
        SABiosciences Custom PCR Arrays for TADA1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TADA1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tada11 , 5 transcriptional adaptor 11, 5 89.15(n)1
    95.82(a)1
      1 (73.74 cM)5
    278781  NM_030245.31  NP_084521.11 
     1663790975 
    chicken
    (Gallus gallus)
    Aves TADA1L1 transcriptional adaptor 1 (HFI1 homolog, yeast)-like 80.2(n)
    91.04(a)
      769871  NM_001197036.1  NP_001183965.1 
    lizard
    (Anolis carolinensis)
    Reptilia TADA16
    --
    83(a)
    1 ↔ 1
    4(71267257-71273314)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183502 Xenopus laevis transcribed sequence with moderate similarity more 74.79(n)    BQ729213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.269092 Danio rerio SPT3-associated factor 42 (STAF42) mRNA, more 71.78(n)    AY423005.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ada1-21 Ada1 44.77(n)
    33.94(a)
      318992  NM_164980.1  NP_723703.1 


    ENSEMBL Gene Tree for TADA1 (if available)
    TreeFam Gene Tree for TADA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TADA1 gene

    TADA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TADA1
    PGOHUM00000249538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/397 NCBI SNPs in TADA1 are shown (see all 397    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817563211,2
    --166825500(+) CCAGAA/GGTCCA 1 -- int10--------
    rs1861145141,2
    --166825516(+) CAGTGA/GGCCAT 1 -- int10--------
    rs779087911,2
    --166825581(+) GAAAAG/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1904843341,2
    --166825744(+) CAACAA/GAGTTT 1 -- int10--------
    rs2019747281,2
    --166825795(+) CAAAT-/ACACAGA 1 -- ut310--------
    rs1507479291,2
    --166825797(+) ATACA-/CAG   
      ATCCAG
    CAGAT
    1 -- ut310--------
    rs563832491,2
    --166825809(+) CAGATA/GTGTGA 1 -- ut310--------
    rs67181,2
    C,F,A,H,--166825837(-) AATGGT/CTGTAT 1 -- ut3128Minor allele frequency- C:0.47MN NA NS EA WA CSA 2753
    rs1830791051,2
    --166826081(+) TTAACC/TGAAGA 1 -- ut310--------
    rs1158960101,2
    F,--166826144(+) GACATA/GAAGTT 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for TADA1 (166825747 - 166845654 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TADA1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TADA1 for disorders           About GeneDecksing

    OMIM gene information: 612763    OMIM disorders: --

    10 diseases for TADA1:    About MalaCards
    tuberculous empyema    severe combined immunodeficiency    pleural tuberculosis    combined immunodeficiency
    essential hypertension    hypertension    t-cell leukemia    tuberculosis
    leukemia    immunodeficiency

    2 diseases from the University of Copenhagen DISEASES database for TADA1:
    Tuberculous empyema     Tuberculosis
    Human Genome Epidemiology (HuGE) Navigator: TADA1 (0 documents)

    Export disorders for TADA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TADA1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TADA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2, 3 Martinez E.... Roeder R.G. (2001)
    2. GCN5 acetylates and regulates the stability of the onc oprotein E2A-PBX1 in acute lymphoblastic leukemia. (PubMed id 23044487)1 Holmlund T....Wallberg A.E. (2013)
    3. Effect of ADA1 mother-fetus and wife-husband phenotypi c differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA. (PubMed id 22287124)1 Gloria-Bottini F....Magrini A. (2012)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A Myc network accounts for similarities between embry onic stem and cancer cell transcription programs. (PubMed id 20946988)1 Kim J....Orkin S.H. (2010)
    7. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    8. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
    9. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1 Cheung C.L....Kung A.W. (2009)
    10. Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. (PubMed id 18250150)1 Gamper A.M. and Roeder R.G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117143 HGNC: 30631 AceView: STAF42 Ensembl:ENSG00000152382 euGenes: HUgn117143
    ECgene: TADA1 H-InvDB: TADA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TADA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TADA1 gene:
    Search GeneIP for patents involving TADA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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