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Aliases for TADA1 Gene

Aliases for TADA1 Gene

  • Transcriptional Adaptor 1 2 3 5
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast) 2 3
  • Transcriptional Adapter 1-Like Protein 3 4
  • TADA1L 3 4
  • STAF42 3 4
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)-Like 2
  • SPT3-Associated Factor 42 (STAF42) 3
  • SPT3-Associated Factor 42 4
  • HADA1 3
  • ADA1 3
  • HFI1 3

External Ids for TADA1 Gene

Previous HGNC Symbols for TADA1 Gene

  • TADA1L

Previous GeneCards Identifiers for TADA1 Gene

  • GC01M165093
  • GC01M138072

Summaries for TADA1 Gene

Entrez Gene Summary for TADA1 Gene

  • TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for TADA1 Gene

TADA1 (Transcriptional Adaptor 1) is a Protein Coding gene. Diseases associated with TADA1 include tuberculous empyema and tuberculous peritonitis. Among its related pathways are Chromatin organization. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot for TADA1 Gene

  • Probably involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA1 Gene

Genomics for TADA1 Gene

Regulatory Elements for TADA1 Gene

Promoters for TADA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TADA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TADA1 Gene

Chromosome:
1
Start:
166,856,510 bp from pter
End:
166,876,417 bp from pter
Size:
19,908 bases
Orientation:
Minus strand

Genomic View for TADA1 Gene

Genes around TADA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA1 Gene

Proteins for TADA1 Gene

  • Protein details for TADA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BN2-TADA1_HUMAN
    Recommended name:
    Transcriptional adapter 1
    Protein Accession:
    Q96BN2
    Secondary Accessions:
    • A8K4J9

    Protein attributes for TADA1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37382 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TADA1 Gene

Proteomics data for TADA1 Gene at MOPED

Post-translational modifications for TADA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA1 Gene

Domains & Families for TADA1 Gene

Gene Families for TADA1 Gene

Protein Domains for TADA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TADA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BN2

UniProtKB/Swiss-Prot:

TADA1_HUMAN :
  • Belongs to the TADA1 family.
Family:
  • Belongs to the TADA1 family.
genes like me logo Genes that share domains with TADA1: view

Function for TADA1 Gene

Molecular function for TADA1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with TADA1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TADA1 Gene

Localization for TADA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA1 Gene COMPARTMENTS Subcellular localization image for TADA1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070461 SAGA-type complex IEA --
genes like me logo Genes that share ontologies with TADA1: view

Pathways & Interactions for TADA1 Gene

genes like me logo Genes that share pathways with TADA1: view

Pathways by source for TADA1 Gene

Gene Ontology (GO) - Biological Process for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TADA1: view

No data available for SIGNOR curated interactions for TADA1 Gene

Drugs & Compounds for TADA1 Gene

No Compound Related Data Available

Transcripts for TADA1 Gene

mRNA/cDNA for TADA1 Gene

Unigene Clusters for TADA1 Gene

Transcriptional adaptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TADA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TADA1 Gene

GeneLoc Exon Structure for
TADA1
ECgene alternative splicing isoforms for
TADA1

Expression for TADA1 Gene

mRNA expression in normal human tissues for TADA1 Gene

Protein differential expression in normal tissues from HIPED for TADA1 Gene

This gene is overexpressed in CD8 Tcells (20.3), CD4 Tcells (17.2), Retina (12.2), and Monocytes (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA1 Gene



SOURCE GeneReport for Unigene cluster for TADA1 Gene Hs.435967

genes like me logo Genes that share expression patterns with TADA1: view

Protein tissue co-expression partners for TADA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TADA1 Gene

Orthologs for TADA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TADA1 35
  • 92.04 (n)
  • 97.31 (a)
TADA1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TADA1 35
  • 92.84 (n)
  • 98.51 (a)
TADA1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tada1 35
  • 89.15 (n)
  • 95.82 (a)
Tada1 16
Tada1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TADA1 35
  • 99.7 (n)
  • 100 (a)
TADA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tada1 35
  • 89.75 (n)
  • 96.72 (a)
oppossum
(Monodelphis domestica)
Mammalia TADA1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves TADA1L 35
  • 80.2 (n)
  • 91.04 (a)
TADA1L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TADA1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8277 35
tada1 35
  • 72.61 (n)
  • 81.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18350 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26909 35
tada1 35
  • 64.93 (n)
  • 66.36 (a)
CABZ01085888.1 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004085 35
  • 45.96 (n)
  • 37.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada1-1 35
  • 44.52 (n)
  • 33.57 (a)
Ada1-1 36
  • 26 (a)
OneToMany
Ada1-2 36
  • 26 (a)
OneToMany
Species with no ortholog for TADA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA1 Gene

ENSEMBL:
Gene Tree for TADA1 (if available)
TreeFam:
Gene Tree for TADA1 (if available)

Paralogs for TADA1 Gene

Pseudogenes.org Pseudogenes for TADA1 Gene

genes like me logo Genes that share paralogs with TADA1: view

No data available for Paralogs for TADA1 Gene

Variants for TADA1 Gene

Sequence variations from dbSNP and Humsavar for TADA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2272792 - 166,860,285(+) GTAAC(C/T)GATAA reference, missense
rs6718 -- 166,856,600(-) AATGG(C/T)TGTAT utr-variant-3-prime
rs760537 -- 166,862,635(+) TTTGC(A/G)TAGTA intron-variant
rs1132732 -- 166,876,203(-) AGGCG(A/G)CCAAG reference, missense
rs1476348 -- 166,863,131(+) AACAA(C/T)ATGGT intron-variant

Variation tolerance for TADA1 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TADA1 Gene

HapMap Linkage Disequilibrium report
TADA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TADA1 Gene

Disorders for TADA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TADA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tuberculous empyema
  • empyema tuberculous
tuberculous peritonitis
  • peritonitis tuberculous
- elite association - COSMIC cancer census association via MalaCards
Search TADA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TADA1

Human Genome Epidemiology (HuGE) Navigator
TADA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TADA1
genes like me logo Genes that share disorders with TADA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TADA1 Gene

Publications for TADA1 Gene

  1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. (PMID: 23044487) Holmlund T. … Wallberg A.E. (Leukemia 2013) 3
  4. Effect of ADA1 mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA. (PMID: 22287124) Gloria-Bottini F. … Magrini A. (Am. J. Hum. Biol. 2012) 3
  5. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (PMID: 20850016) Vermeulen M. … Mann M. (Cell 2010) 3

Products for TADA1 Gene

Sources for TADA1 Gene

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