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Aliases for TADA1 Gene

Aliases for TADA1 Gene

  • Transcriptional Adaptor 1 2 3
  • TADA1L 3 4 6
  • STAF42 3 4 6
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast) 2 3
  • Transcriptional Adapter 1-Like Protein 3 4
  • Transcriptional Adaptor 1 (HFI1 Homolog, Yeast)-Like 2
  • SPT3-Associated Factor 42 (STAF42) 3
  • Transcriptional Adapter 1 3
  • SPT3-Associated Factor 42 4
  • HADA1 3
  • ADA1 3
  • HFI1 3

External Ids for TADA1 Gene

Previous HGNC Symbols for TADA1 Gene

  • TADA1L

Previous GeneCards Identifiers for TADA1 Gene

  • GC01M165093
  • GC01M138072

Summaries for TADA1 Gene

Entrez Gene Summary for TADA1 Gene

  • TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

GeneCards Summary for TADA1 Gene

TADA1 (Transcriptional Adaptor 1) is a Protein Coding gene. Diseases associated with TADA1 include tuberculous empyema. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot for TADA1 Gene

  • Probably involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA1 Gene

Genomics for TADA1 Gene

Genomic Location for TADA1 Gene

Start:
166,856,510 bp from pter
End:
166,876,417 bp from pter
Size:
19,908 bases
Orientation:
Minus strand

Genomic View for TADA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TADA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA1 Gene

No data available for Regulatory Elements for TADA1 Gene

Proteins for TADA1 Gene

  • Protein details for TADA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BN2-TADA1_HUMAN
    Recommended name:
    Transcriptional adapter 1
    Protein Accession:
    Q96BN2
    Secondary Accessions:
    • A8K4J9

    Protein attributes for TADA1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37382 Da
    Quaternary structure:
    • Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TADA1 Gene

Proteomics data for TADA1 Gene at MOPED

Post-translational modifications for TADA1 Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for TADA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA1 Gene

Domains for TADA1 Gene

Protein Domains for TADA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TADA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BN2

UniProtKB/Swiss-Prot:

TADA1_HUMAN :
  • Q96BN2
Family:
  • Belongs to the TADA1 family.
genes like me logo Genes that share domains with TADA1: view

No data available for Gene Families for TADA1 Gene

Function for TADA1 Gene

Molecular function for TADA1 Gene

UniProtKB/Swiss-Prot Function: Probably involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with TADA1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TADA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TADA1 Gene

Localization for TADA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA1 Gene COMPARTMENTS Subcellular localization image for TADA1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with TADA1: view

Pathways for TADA1 Gene

genes like me logo Genes that share pathways with TADA1: view

Pathways by source for TADA1 Gene

Gene Ontology (GO) - Biological Process for TADA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TADA1: view

Transcripts for TADA1 Gene

mRNA/cDNA for TADA1 Gene

Unigene Clusters for TADA1 Gene

Transcriptional adaptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TADA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TADA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TADA1 Gene

GeneLoc Exon Structure for
TADA1
ECgene alternative splicing isoforms for
TADA1

Expression for TADA1 Gene

mRNA expression in normal human tissues for TADA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA1 Gene

SOURCE GeneReport for Unigene cluster for TADA1 Gene Hs.435967

genes like me logo Genes that share expressions with TADA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TADA1 Gene

Orthologs for TADA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TADA1 35
  • 99.7 (n)
  • 100 (a)
TADA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TADA1 35
  • 92.04 (n)
  • 97.31 (a)
TADA1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TADA1 35
  • 92.84 (n)
  • 98.51 (a)
TADA1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tada1 35
  • 89.15 (n)
  • 95.82 (a)
Tada1 16
Tada1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TADA1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tada1 35
  • 89.75 (n)
  • 96.72 (a)
chicken
(Gallus gallus)
Aves TADA1L 35
  • 80.2 (n)
  • 91.04 (a)
TADA1L 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TADA1 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18350 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8277 35
tada1 35
  • 72.61 (n)
  • 81.57 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01085888.1 36
  • 61 (a)
OneToOne
Dr.26909 35
tada1 35
  • 64.93 (n)
  • 66.36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004085 35
  • 45.96 (n)
  • 37.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada1-1 35
  • 44.52 (n)
  • 33.57 (a)
Ada1-1 36
  • 26 (a)
OneToMany
Ada1-2 36
  • 26 (a)
OneToMany
Species with no ortholog for TADA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA1 Gene

ENSEMBL:
Gene Tree for TADA1 (if available)
TreeFam:
Gene Tree for TADA1 (if available)

Paralogs for TADA1 Gene

Pseudogenes.org Pseudogenes for TADA1 Gene

genes like me logo Genes that share paralogs with TADA1: view

No data available for Paralogs for TADA1 Gene

Variants for TADA1 Gene

Sequence variations from dbSNP and Humsavar for TADA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6718 -- 166,856,600(-) AATGG(C/T)TGTAT utr-variant-3-prime
rs760537 -- 166,862,635(+) TTTGC(A/G)TAGTA intron-variant
rs1132732 -- 166,876,203(-) AGGCG(A/G)CCAAG missense, reference
rs1476348 -- 166,863,131(+) AACAA(C/T)ATGGT intron-variant
rs1476349 -- 166,863,217(+) ATCCC(A/G)ATGGC intron-variant

Relevant External Links for TADA1 Gene

HapMap Linkage Disequilibrium report
TADA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TADA1 Gene

Disorders for TADA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TADA1 Gene including...

Search for TADA1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TADA1 Gene

Relevant External Links for TADA1

Human Genome Epidemiology (HuGE) Navigator
TADA1
genes like me logo Genes that share disorders with TADA1: view

No data available for UniProtKB/Swiss-Prot for TADA1 Gene

Publications for TADA1 Gene

  1. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. (PMID: 18250150) Gamper A.M. … Roeder R.G. (Mol. Cell. Biol. 2008) 3

Products for TADA1 Gene

Sources for TADA1 Gene

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