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TACSTD2 Gene

protein-coding   GIFtS: 59

GC01M058813
tumor-associated calcium signal transducer 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: M1S1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
EGP-1 1, 2
GA733 2
GA733-1 1, 2, 3
M1S1 2, 3, 5
OTTHUMP00000011755 2
TROP2 1, 2, 3, 5
Descriptions
Cell surface glycoprotein Trop-2 3
Pancreatic carcinoma marker protein GA733-1 3
epithelial glycoprotein-1 2
membrane component, chromosome 1, surface marker 1 (40kD
glycoprotein, identified by monoclonal antibody GA733) 2
tumor-associated calcium signal transducer 2 2
External Ids
HGNC: 115301
Entrez Gene: 40702
UniProtKB: P097583
Ensembl: ENSG000001842927
Search outside databases for aliases for TACSTD2 gene

Previous GC identifers: GC01M058957 GC01M057955 GC01M058398 GC01M058411 GC01M058412 GC01M058752

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TACSTD2:
This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody
GA733. This antigen is a member of a family including at least two type I membrane proteins. It
transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this
gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder
characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq]

UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
Function: GA733 tumor-associated antigen gene family may function as growth factor receptors

Gene Wiki entry for TACSTD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TACSTD2 gene  

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32

TACSTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M058813:     (about GC identifiers)

Start:
58,813,231 bp from pter
End:
58,816,033 bp from pter
Size:
2,803 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758 (See protein sequence)
Recommended Name: Tumor-associated calcium signal transducer 2 precursor  
Size: 323 amino acids; 35709 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q15658 Q96QD2

Post-translational modifications:

  • The N-terminus is blocked1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002344.2  

    ENSEMBL proteins: 
    ENSP00000360269 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for TACSTD2 (TROP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TACD2)
    Human Recombinant Proteins from Abnova (TACSTD2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol TAS10192395
    GO:0005887 integral to plasma membrane TAS7665234
    GO:0016020 membrane TAS8382772
    About this table

    Antibodies for TACSTD2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for TACSTD2 (TROP-2)
    Antibodies from Abcam (TACD2), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for TACSTD2

    Assays for TACSTD2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000716 Thyroglobulin_1


       GeneDecks  TACSTD2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P09758

    ProtoNet protein and cluster: P09758

    1 Blocks protein family: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Similarity: Contains 1 thyroglobulin type-1 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACSTD2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACSTD2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002353

                  Applied Biosystems Silencer® siRNAs for TACSTD2

                  Sigma-Aldrich siRNA and siRNA Panels for TACSTD2  
                         Sigma-Aldrich shRNA for TACSTD2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002353
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002353
                                     untagged cDNA clone in CMV expression vector: NM_002353 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002353

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Function: GA733 tumor-associated antigen gene family may function as growth factor receptors

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity TAS7665234
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  TACSTD2 


    3 Interacting proteins for TACSTD2 (ENSP000003602693) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBIENSP000003063063STRING (score=.855)
    NBPF20ENSP000003582033STRING (score=.702)
    HLA-CENSP000003654023STRING (score=.701)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166 cell surface receptor linked signal transduction TAS7665234
    GO:0007601 visual perception TAS10192395
    GO:0008283 cell proliferation TAS7665234
    GO:0050896 response to stimulus IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TACSTD2
    1 Novoseek chemical compound relationship for TACSTD2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0.00 2 15305371 (1), 16232198 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACSTD2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACSTD2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002353

                  Sigma-Aldrich siRNA and siRNA Panels for TACSTD2  
                         Sigma-Aldrich shRNA for TACSTD2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002353  

    REFSEQ mRNAs for TACSTD2 gene: 

    NM_002353.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002353  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002353
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002353
                                     untagged cDNA clone in CMV expression vector: NM_002353 

    Additional cDNA sequence: 

    BC009409.1 BT007255.1 CR542260.1 X13425.1 X77753.1 

    7 DOTS entries:

    DT.450146  DT.95276450  DT.99927981  DT.121426551  DT.97813372  DT.92440454  DT.95183330 

    24/302 AceView cDNA sequences (see all 302 ):

    AW070311 BM784500 BG259957 AA708777 AI741714 BF739923 BM765888 AW384489 
    AW261984 AI524333 AA056370 AA370887 BG259850 W67579 AA857791 BE122900 
    BG260715 BM980300 W68600 BM129041 AI004919 H29722 AA429148 AA434338 

    highest scoring ESTs for TACSTD2:

    X77753 AA045944 AA115151 AA159538 AA235686 AA291648 AA320951 AA401708 AA401961 AA411472 

    Unigene Cluster for TACSTD2:

    Tumor-associated calcium signal transducer 2
    Hs.23582  [show with all ESTs]
    Unigene Representative Sequence: X77753


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000371225  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TACSTD2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TACSTD2

    1 / 2 / 3

    8 probe-sets matching TACSTD2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    291_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.30 J04152 0.20 1.00 0.72 1

    41286_at2, 3 U95-A 1 1.00 1.00 0.89 0.74 X77753 1.00 1.00 1.00 1

    202286_s_at2, 3 U133-A 1 1.00 1.00 -- -- J04152 0.20 1.00 0.72 1

    202287_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002353 0.60 1.00 0.82 1

    202285_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI627697 0.80 1.00 0.91 1

    202286_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202287_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202285_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TACSTD2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCTACCCGA

    SOURCE GeneReport for Unigene cluster: Hs.23582

    Expression variation in blood from EXPOLDB for TACSTD2

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Tissue specificity: Placenta, pancreatic carcinoma cell lines

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TACSTD2 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TACSTD21   -- tumor-associated calcium signal transducer 2 88.3(n)
    84.04(a)
    610286  XM_847749.1  XP_852842.1 
    chimpanzee
    (Pan troglodytes)
    TACSTD21   -- tumor-associated calcium signal transducer 2 99.69(n)
    99.69(a)
    456890  XM_513439.2  XP_513439.2 
    cow
    (Bos taurus)
    TACSTD21   -- tumor-associated calcium signal transducer 2 86.31(n)
    80.56(a)
    539853  XM_589840.3  XP_589840.1 
    rat
    (Rattus norvegicus)
    Tacstd21   -- tumor-associated calcium signal transducer 2 81.6(n)
    80.76(a)
    494343  NM_001009540.2  NP_001009540.2 
    mouse
    (Mus musculus)
    Tacstd21, 5 65
    tumor-associated calcium signal transducer 21, 5 81.28(n)1
    79.81(a)1
    567531  NM_020047.31  NP_064431.21 
     AA3873195  AI3241755  (see all 17)
    About this table        Species with no ortholog for TACSTD2

    ENSEMBL Gene Tree for TACSTD2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TACSTD2 gene
    EPCAM2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/57 NCBI SNPs in TACSTD2 are shown (see all 57 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 75)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10629641,2
    A,C,F,H58814976(-) GATGAG/CCTGGT 1 D/E mis1 ese35Minor allele frequency- C:0.04EU EA WA NA 494
    --
    rs66836691,2
    A,C,F,H58813680(+) ATGCCG/AACTTC 1 -- ut314Minor allele frequency- A:0.19EU EA WA 410
    rs140081,2
    A,C,F,H58814769(-) GGTGAC/AGTGGA 1 E/D mis1 ese312Minor allele frequency- A:0.10MN EA EU WA NA 2752
    rs73331,2
    A,C,F,H58813808(-) TTACTG/ACCACT 1 -- ut31 ese39Minor allele frequency- A:0.23MN EU EA WA 996
    rs2328401,2
    A,C,F,H58813307(-) AAATAA/GGTGGT 1 -- ut316Minor allele frequency- G:0.30EU EA WA NA 598
    rs22689431,2
    A,C,F,H58813644(+) ACCAAT/AGTGAT 1 -- ut315Minor allele frequency- A:0.14EA EU WA 1726
    rs95831,2
    C,F,H58814024(-) ATTTGA/GTGAGT 1 -- ut316Minor allele frequency- G:0.10MN EU EA WA 780
    rs35511,2
    A,C,F58814165(-) TGGCAT/CAGCGT 1 -- ut313Minor allele frequency- C:0.43MN 556
    rs2328351,2
    A,C58815470(-) CCCCGA/CCGAGT 1 -- ut51 ese32Minor allele frequency- C:0.00EA NA 24
    rs2328421,2
    A,C58812758(-) TTTCAC/GTCATT 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for TACSTD2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 137290   disorders: 204870  

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758

  • Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD)
    [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive
    disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment
  • 9 Novoseek disease relationships for TACSTD2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis, corneal 96.92 12 11004271 (4), 15295654 (2), 17653040 (2), 17898270 (1) (see all 6)
    corneal dystrophy 88.63 10 17721311 (2), 12614764 (2), 11687514 (2), 15013888 (1) (see all 7)
    lattice corneal dystrophy 81.91 1 12700042 (1)
    gastrointestinal carcinoma 65.36 1 11058587 (1)
    ovarian carcinoma 38.73 1 19053170 (1)
    carcinoma 31.53 5 7665234 (2), 2333300 (1), 15355929 (1), 14999147 (1)
    pancreatic cancer 19.83 1 10473862 (1)
    tumors 4.31 2 9586666 (1), 10881691 (1)
    adenocarcinoma 0.00 1 16232198 (1)
    About this table

    Human Gene Mutation Database: TACSTD2
    Genetic Association Database: TACSTD2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/59 PubMed articles for TACSTD2 gene (see all 59 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4070 HGNC: 11530 AceView: TACSTD2 Ensembl:ENSG00000184292 euGenes: HUgn4070
    ECgene: TACSTD2 H-InvDB: TACSTD2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for TACSTD2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=TACSTD2
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TACSTD2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for TACSTD2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TACSTD2 Browse small molecules at Sigma-Aldrich
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