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TACSTD2 Gene

protein-coding   GIFtS: 61
GCID: GC01M059041

Tumor-Associated Calcium Signal Transducer 2


(Previous symbol: M1S1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor-Associated Calcium Signal Transducer 21 2     EGP12
M1S11 2 3 5     GA73312
TROP22 3 5     GP502
Cell Surface Glycoprotein Trop-22 3     Cell Surface Glycoprotein TROP22
Membrane Component Chromosome 1 Surface Marker 12 3     Epithelial Glycoprotein-12
Pancreatic Carcinoma Marker Protein GA733-12 3     Gastrointestinal Tumor-Associated Antigen GA73312
GA733-12 3     Membrane Component, Chromosome 1, Surface Marker 12
40kD Glycoprotein, Identified By Monoclonal Antibody GA7332     Pancreatic Carcinoma Marker Protein GA73312
EGP-12     

External Ids:    HGNC: 115301   Entrez Gene: 40702   Ensembl: ENSG000001842927   OMIM: 1372905   UniProtKB: P097583   

Export aliases for TACSTD2 gene to outside databases

Previous GC identifers: GC01M058957 GC01M057955 GC01M058398 GC01M058411 GC01M058412 GC01M058752 GC01M058813 GC01M057151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TACSTD2 Gene:
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that
transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal
dystrophy.(provided by RefSeq, Dec 2009)

GeneCards Summary for TACSTD2 Gene:
TACSTD2 (tumor-associated calcium signal transducer 2) is a protein-coding gene. Diseases associated with TACSTD2 include honey-droplet corneal dystrophy, and amyloidosis corneal. GO annotations related to this gene include receptor activity. An important paralog of this gene is EPCAM.

UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
Function: May function as a growth factor receptor

Gene Wiki entry for TACSTD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TACSTD2 gene promoter:
         AhR   Nkx3-1   Nkx3-1 v4   AML1a   FOXD3   Nkx3-1 v1   XBP-1   HEN1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TACSTD2 promoter sequence
   Search Chromatin IP Primers for TACSTD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TACSTD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32

TACSTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACSTD2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M059041:  view genomic region     (about GC identifiers)

Start:
59,041,095 bp from pter      End:
59,043,166 bp from pter
Size:
2,072 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758 (See protein sequence)
Recommended Name: Tumor-associated calcium signal transducer 2 precursor  
Size: 323 amino acids; 35709 Da
Secondary accessions: Q15658 Q6FG48 Q7Z7Q4 Q96QD2

Explore the universe of human proteins at neXtProt for TACSTD2: NX_P09758

Explore proteomics data for TACSTD2 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Glycosylation2 at Asn33, Ser93, Asn120, Asn168, Asn208
  • Modification sites at PhosphoSitePlus

  • See TACSTD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002344.2  
    ENSEMBL proteins: 
     ENSP00000360269  

    TACSTD2 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for TACSTD2 (TROP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TACSTD2
    OriGene Protein Over-expression Lysate for TACSTD2
    OriGene MassSpec for TACSTD2
    OriGene Custom Protein Services for TACSTD2
    GenScript Custom Purified and Recombinant Proteins Services for TACSTD2
    Novus Biologicals TACSTD2 Proteins
    Novus Biologicals TACSTD2 Lysate
    Sino Biological Recombinant Protein for TACSTD2
    Sino Biological Cell Lysate for TACSTD2
    ProSpec Recombinant Protein for TACSTD2
    Cloud-Clone Corp. Proteins for TACSTD2

    TACSTD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TACSTD2 (TROP-2)
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    Novus Biologicals TACSTD2 Antibodies
    Abcam antibodies for TACSTD2
    Cloud-Clone Corp. Antibodies for TACSTD2
    ThermoFisher Antibodies for TACSTD2
    LSBio Antibodies in human, mouse, rat for TACSTD2

    TACSTD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TACSTD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TACSTD2
    Cloud-Clone Corp. CLIAs for TACSTD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry P09758

    ProtoNet protein and cluster: P09758

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Similarity: Belongs to the EPCAM family
    Similarity: Contains 1 thyroglobulin type-1 domain


    TACSTD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TACD2_HUMAN, P09758
    Function: May function as a growth factor receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7665234
         
    TACSTD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TACSTD2:
     Decreased cilium length after  

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tacstd2):
     cellular  embryogenesis  homeostasis/metabolism  integument  mortality/aging 
     tumorigenesis 

    TACSTD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tacstd2tm1Lsm for TACSTD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TACSTD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TACSTD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TACSTD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TACSTD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TACSTD2:
    hsa-mir-155-5p (MIRT001496), hsa-mir-335-5p (MIRT017057)

    Block miRNA regulation of human, mouse, rat TACSTD2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TACSTD2:
    hsa-miR-877* hsa-miR-550a hsa-miR-495 hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTACSTD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TACSTD2
    Predesigned siRNA for gene silencing in human, mouse, rat TACSTD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TACSTD2

    Clone
    Products:
         
    OriGene clones in human, mouse for TACSTD2 (see all 6)
    OriGene ORF clones in mouse, rat for TACSTD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TACSTD2 (NM_002353)
    Sino Biological Human cDNA Clone for TACSTD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACSTD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACSTD2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TACSTD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TACSTD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACSTD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TACD2_HUMAN, P09758: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS10192395
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS7665234

    TACSTD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TACSTD2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TACSTD2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TACSTD2 (P097583 ENSP000003602694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ663I2D: score=1 
    ATF2ENSP000002641104STRING: ENSP00000264110
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    SIRT3ENSP000003721914STRING: ENSP00000372191
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7665234
    GO:0007601visual perception IEA--
    GO:0008283cell proliferation TAS7665234
    GO:0010633negative regulation of epithelial cell migration ISS--
    GO:0050678regulation of epithelial cell proliferation IEA--

    TACSTD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TACSTD2 (TACD2)

    3 Novoseek inferred chemical compound relationships for TACSTD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aspartate 9.35 3 15254496 (1), 11687514 (1)
    calcium 2.1 4 15305371 (1), 20454699 (1), 16232198 (1), 19693293 (1)
    alanine 2.07 3 15254496 (1), 11687514 (1)



    TACSTD2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TACSTD2 gene: 
    NM_002353.2  

    Unigene Cluster for TACSTD2:

    Tumor-associated calcium signal transducer 2
    Hs.23582  [show with all ESTs]
    Unigene Representative Sequence: X77753
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371225(uc001cyz.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TACSTD2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TACSTD2:
    hsa-miR-877* hsa-miR-550a hsa-miR-495 hsa-miR-520d-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTACSTD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TACSTD2
    Predesigned siRNA for gene silencing in human, mouse, rat TACSTD2
    Clone
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    OriGene clones in human, mouse for TACSTD2 (see all 6)
    OriGene ORF clones in mouse, rat for TACSTD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TACSTD2 (NM_002353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACSTD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACSTD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TACSTD2
    OriGene qSTAR qPCR primer pairs in human, mouse for TACSTD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TACSTD2
      QuantiTect SYBR Green Assays in human, mouse, rat TACSTD2
      QuantiFast Probe-based Assays in human, mouse, rat TACSTD2

    Additional mRNA sequence: 

    BC009409.1 BT007255.1 CR542260.1 X13425.1 X77753.1 

    7 DOTS entries:

    DT.450146  DT.95276450  DT.99927981  DT.121426551  DT.97813372  DT.92440454  DT.95183330 

    Selected AceView cDNA sequences (see all 302):

    AA434338 AA429148 AI738946 W68600 BF435824 BM980300 BU674492 BE736713 
    AA041250 CB159473 AW006838 BM825095 W67579 AA857791 AI004919 AA708777 
    AI634877 AW261984 BE122900 AA370887 BM128801 AI201870 H29722 N70156 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TACSTD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTACCCGA
    TACSTD2 Expression
    About this image


    TACSTD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
             Vas Deferens
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Lower Urinary Tract (Urinary System)
             Ureter
    TACSTD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TACSTD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23582

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Tissue specificity: Placenta, pancreatic carcinoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including TACSTD2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TACSTD2
    OriGene qSTAR qPCR primer pairs in human, mouse for TACSTD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TACSTD2
    QuantiTect SYBR Green Assays in human, mouse, rat TACSTD2
    QuantiFast Probe-based Assays in human, mouse, rat TACSTD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACSTD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TACSTD2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacstd21 , 5 tumor-associated calcium signal transducer 21, 5 81.94(n)1
    80.6(a)1
      6 (30.88 cM)5
    567531  NM_020047.31  NP_064431.21 
     675340595 
    chicken
    (Gallus gallus)
    Aves TACSTD21 tumor-associated calcium signal transducer 2 52.41(n)
    46.29(a)
      772378  NM_001277676.1  NP_001264605.1 
    lizard
    (Anolis carolinensis)
    Reptilia TACSTD26
    tumor-associated calcium signal transducer 2
    52(a)
    1 ↔ 1
    4(101996415-102009148)
    zebrafish
    (Danio rerio)
    Actinopterygii epcam6
    epithelial cell adhesion molecule
    35(a)
    1 → many
    13(8206229-8208820) ENSDARG00000040534


    ENSEMBL Gene Tree for TACSTD2 (if available)
    TreeFam Gene Tree for TACSTD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TACSTD2 gene
    EPCAM2  
    1 SIMAP similar gene for TACSTD2 using alignment to 3 protein entries:     TACD2_HUMAN (see all proteins):
    EPCAM

    TACSTD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TACSTD2 (see all 144)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs803582241,2
    Cpathogenic159117750(-) TGCGGC/TAGAAC 2 Q * stg10--------
    rs803582281,2
    Cpathogenic159117812(-) TCGGCC/TGCACC 2 P L mis10--------
    rs803582251,2
    Cpathogenic159117860(-) CCACTA/CAGACC 2 * S stg10--------
    rs803582271,2
    Cpathogenic159118014(-) GTTGCA/TCTGGC 2 S C mis10--------
    rs803582231,2
    Cpathogenic159118017(-) CGCGCC/TAGTGC 2 Q * stg10--------
    rs803582261,2
    Cpathogenic159118368(-) CACCAG/TGGCTC 2 R M mis10--------
    rs2328331,2
    C,F,A,H--57155136(-) aaaaAG/AAAATT 1 -- us2k13Minor allele frequency- A:0.29NA WA CSA 7
    rs112072631,2
    C,F,A,H--57155140(+) TTTttG/Tttttt 1 -- us2k12Minor allele frequency- T:0.50NA WA 6
    rs113583431,2
    C--59040847(+) GCTAGT/-TTTAG 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs350289961,2
    C--59043509(+) TCATA-/TTTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TACSTD2 (59041095 - 59043166 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TACSTD2: --
    Human Gene Mutation Database (HGMD): TACSTD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TACSTD2
    DNA2.0 Custom Variant and Variant Library Synthesis for TACSTD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137290   
    OMIM disorders: 204870  
    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
  • Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class
    of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is
    an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical
    manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body
    sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for TACSTD2 (see all 26):    
    About MalaCards
    honey-droplet corneal dystrophy    amyloidosis corneal    recurrent corneal erosion    ovarian carcinosarcoma
    cysticercosis    lattice corneal dystrophy    corneal dystrophy    lung adenocarcinoma
    pancreatitis    amyloidosis    pancreatic cancer    papillary carcinoma
    peritonitis    hepatitis c virus    hepatitis c    adenocarcinoma
    ovarian cancer    colorectal cancer    squamous cell carcinoma    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for TACSTD2:
    Corneal dystrophy     Cysticercosis

    TACSTD2 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for TACSTD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis, corneal 97.3 15 11004271 (4), 15295654 (2), 17653040 (2), 19693293 (2) (see all 8)
    corneal dystrophy 87.9 10 17721311 (2), 12614764 (2), 11687514 (2), 15013888 (1) (see all 7)
    lattice corneal dystrophy 81 1 12700042 (1)
    gastrointestinal carcinoma 64 1 11058587 (1)
    ovarian carcinoma 37.2 1 19053170 (1)
    carcinoma 30 5 7665234 (2), 2333300 (1), 15355929 (1), 14999147 (1)
    pancreatic cancer 17.4 1 10473862 (1)
    tumors 1.99 2 9586666 (1), 10881691 (1)
    adenocarcinoma 0 1 16232198 (1)

    Genetic Association Database (GAD): TACSTD2

    Export disorders for TACSTD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TACSTD2 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with TACSTD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retroposition in a family of carcinoma-associated antigen genes. (PubMed id 8382772)1, 2, 3, 9 Linnenbach A.J.... Huebner K. (Mol. Cell. Biol. 1993)
    2. A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. (PubMed id 11687514)1, 2, 9 Tasa G.... Lang A. (Invest. Ophthalmol. Vis. Sci. 2001)
    3. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. (PubMed id 7665234)1, 2, 9 Fornaro M.... Alberti S. (Int. J. Cancer 1995)
    4. Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. (PubMed id 15013888)1, 4, 9 Tian X....Liu Z. (Am. J. Ophthalmol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. (PubMed id 11306819)1, 3 Calabrese G....Alberti S. (Cytogenet. Cell Genet. 2001)
    7. Identification of the gene responsible for gelatinous drop-like corneal dystrophy. (PubMed id 10192395)1, 2 Tsujikawa M.... Nakamura Y. (Nat. Genet. 1999)
    8. Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. (PubMed id 2911574)1, 2 Linnenbach A.J.... Koprowski H. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    9. Four mutations (three novel, one founder) in TACSTD2 among Iranian GDLD patients. (PubMed id 17898270)1, 9 Alavi A....Amini S.S. (amp 2007)
    10. Detection of mRNAs of GA733 genes by RT-PCR in exfoliated cells of pleural and peritoneal effusions and its clinical values. (PubMed id 17878632)1, 9 Zhang K.H....Lv N.H. (Intern. Med. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4070 HGNC: 11530 AceView: TACSTD2 Ensembl:ENSG00000184292 euGenes: HUgn4070
    ECgene: TACSTD2 H-InvDB: TACSTD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TACSTD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TACSTD2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/243945/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TACSTD2 gene:
    Search GeneIP for patents involving TACSTD2

    GeneCards and IP:
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