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Aliases & Descriptions for TACSTD2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EGP-1 1, 2 | | GA733 2 | | GA733-1 1, 2, 3 | | M1S1 2, 3, 5 | | OTTHUMP00000011755 2 | | TROP2 1, 2, 3, 5 |
| | | Descriptions |
|---|
| Cell surface glycoprotein Trop-2 3 | | Pancreatic carcinoma marker protein GA733-1 3 | | epithelial glycoprotein-1 2 | membrane component, chromosome 1, surface marker 1 (40kD glycoprotein, identified by monoclonal antibody GA733) 2 | | tumor-associated calcium signal transducer 2 2 |
|
| | Search outside databases for aliases for TACSTD2 genePrevious GC identifers: GC01M058957 GC01M057955 GC01M058398 GC01M058411 GC01M058412 GC01M058752 |
Summaries for TACSTD2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TACSTD2: This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq] UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758Function: GA733 tumor-associated antigen gene family may function as growth factor receptorsGene Wiki entry for TACSTD2 |
Genomic Location for TACSTD2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TACSTD2 gene 
Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p32TACSTD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M058813:
(about GC identifiers)
Start:
|
58,813,231 bp from pter |
End:
|
58,816,033 bp from pter |
Size:
|
2,803 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for TACSTD2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758 (See
protein sequence)Recommended Name: Tumor-associated calcium signal transducer 2 precursor Size: 323 amino acids; 35709 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q15658 Q96QD2Post-translational modifications:
The N-terminus is blocked1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002344.2
ENSEMBL proteins: ENSP00000360269
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TACSTD2: Assays for TACSTD2: | Protein
Domains/ Families for TACSTD2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P09758
ProtoNet protein and cluster: P09758 1 Blocks protein family: IPB000716 Thyroglobulin type-1
UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758Similarity: Contains 1 thyroglobulin type-1 domain | Gene Function for TACSTD2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002353
Applied Biosystems Silencer® siRNAs for TACSTD2
Sigma-Aldrich siRNA and siRNA Panels for TACSTD2  Sigma-Aldrich shRNA for TACSTD2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002353                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002353                                  untagged cDNA clone in CMV expression vector: NM_002353 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002353
UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758Function: GA733 tumor-associated antigen gene family may function as growth factor receptors1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for TACSTD2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for TACSTD2 
3 Interacting proteins for TACSTD2 (ENSP000003602693) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for TACSTD2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TACSTD2 1 Novoseek chemical compound relationship for TACSTD2 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
0.00 |
2 |
15305371 (1), 16232198 (1) |
About this table
|
Transcripts for TACSTD2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002353
Sigma-Aldrich siRNA and siRNA Panels for TACSTD2  Sigma-Aldrich shRNA for TACSTD2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002353 REFSEQ mRNAs for TACSTD2 gene: NM_002353.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002353               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002353                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002353                                  untagged cDNA clone in CMV expression vector: NM_002353  Additional cDNA sequence: BC009409.1 BT007255.1 CR542260.1 X13425.1 X77753.1 7 DOTS entries: DT.450146 DT.95276450 DT.99927981 DT.121426551 DT.97813372 DT.92440454 DT.95183330 24/302 AceView cDNA sequences (see all 302
):AW070311 BM784500 BG259957 AA708777 AI741714 BF739923 BM765888 AW384489 AW261984 AI524333 AA056370 AA370887 BG259850 W67579 AA857791 BE122900 BG260715 BM980300 W68600 BM129041 AI004919 H29722 AA429148 AA434338
highest scoring ESTs for TACSTD2:X77753 AA045944 AA115151 AA159538 AA235686 AA291648 AA320951 AA401708 AA401961 AA411472 Unigene Cluster for TACSTD2: Tumor-associated calcium signal transducer 2 Hs.23582 [show with all ESTs]Unigene Representative Sequence: X77753
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000371225
|
Expression for TACSTD2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TACSTD2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TACSTD2
1 / 2 / 3 8 probe-sets matching TACSTD2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCTACCCGA
SOURCE GeneReport for Unigene cluster: Hs.23582
Expression variation in blood from EXPOLDB for TACSTD2 UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758Tissue specificity: Placenta, pancreatic carcinoma cell lines |
Orthologs for TACSTD2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TACSTD2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TACSTD2
ENSEMBL Gene Tree for TACSTD2 | Paralogs for TACSTD2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TACSTD2 gene
- EPCAM2
|
SNPs/Variants for TACSTD2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TACSTD2 (up to first 250kb)
|
Disorders & Mutations for TACSTD2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 137290 disorders: 204870 UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment9 Novoseek disease relationships for TACSTD2 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| amyloidosis, corneal |
96.92 |
12 |
11004271 (4), 15295654 (2), 17653040 (2), 17898270 (1) (see all 6) |
| corneal dystrophy |
88.63 |
10 |
17721311 (2), 12614764 (2), 11687514 (2), 15013888 (1) (see all 7) |
| lattice corneal dystrophy |
81.91 |
1 |
12700042 (1) |
| gastrointestinal carcinoma |
65.36 |
1 |
11058587 (1) |
| ovarian carcinoma |
38.73 |
1 |
19053170 (1) |
| carcinoma |
31.53 |
5 |
7665234 (2), 2333300 (1), 15355929 (1), 14999147 (1) |
| pancreatic cancer |
19.83 |
1 |
10473862 (1) |
| tumors |
4.31 |
2 |
9586666 (1), 10881691 (1) |
| adenocarcinoma |
0.00 |
1 |
16232198 (1) |
About this table
Human Gene Mutation Database: TACSTD2 Genetic Association Database: TACSTD2
|
Medical News for TACSTD2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TACSTD2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/59 PubMed articles for TACSTD2 gene (see all 59
):- Retroposition in a family of carcinoma-associated antigen genes. (PubMed id 8382772)1, 2, 3, 4 Linnenbach A.J.... Huebner K. (1993)
- A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. (PubMed id 11687514)1, 3, 4 Tasa G.... Lang A. (2001)
- Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. (PubMed id 7665234)1, 3, 4 Fornaro M.... Alberti S. (1995)
- Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. (PubMed id 15013888)1, 3, 6 Tian X....Liu Z. (2004)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. (PubMed id 11306819)2, 3 Calabrese G....Alberti S. (2001)
- Identification of the gene responsible for gelatinous drop-like corneal dystrophy. (PubMed id 10192395)3, 4 Tsujikawa M.... Nakamura Y. (1999)
- Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. (PubMed id 2911574)3, 4 Linnenbach A.J.... Koprowski H. (1989)
- Four mutations (three novel, one founder) in TACSTD2 among Iranian GDLD patients. (PubMed id 17898270)1, 3 Alavi A....Amini S.S. (2007)
|
Search for TACSTD2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TACSTD2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TACSTD2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TACSTD2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TACSTD2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TACSTD2:

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Incremental update: 13 Oct 2009
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