Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TACSTD2 Gene

Aliases for TACSTD2 Gene

  • Tumor-Associated Calcium Signal Transducer 2 2 3
  • TROP2 3 4 6
  • M1S1 3 4 6
  • Membrane Component Chromosome 1 Surface Marker 1 3 4
  • Pancreatic Carcinoma Marker Protein GA733-1 3 4
  • Cell Surface Glycoprotein Trop-2 3 4
  • GA733-1 3 4
  • 40kD Glycoprotein, Identified By Monoclonal Antibody GA733 3
  • Membrane Component, Chromosome 1, Surface Marker 1 3
  • Gastrointestinal Tumor-Associated Antigen GA7331 3
  • Pancreatic Carcinoma Marker Protein GA7331 3
  • Cell Surface Glycoprotein TROP2 3
  • Epithelial Glycoprotein-1 3
  • GA7331 3
  • EGP-1 3
  • EGP1 3
  • GP50 3

External Ids for TACSTD2 Gene

Previous Symbols for TACSTD2 Gene

  • M1S1

Summaries for TACSTD2 Gene

Entrez Gene Summary for TACSTD2 Gene

  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

GeneCards Summary for TACSTD2 Gene

TACSTD2 (Tumor-Associated Calcium Signal Transducer 2) is a Protein Coding gene. Diseases associated with TACSTD2 include corneal dystrophy, gelatinous drop-like and gastrointestinal carcinoma. GO annotations related to this gene include receptor activity. An important paralog of this gene is EPCAM.

UniProtKB/Swiss-Prot for TACSTD2 Gene

  • May function as a growth factor receptor

Gene Wiki entry for TACSTD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACSTD2 Gene

Genomics for TACSTD2 Gene

Genomic Location for TACSTD2 Gene

Start:
58,575,423 bp from pter
End:
58,577,773 bp from pter
Size:
2,351 bases
Orientation:
Minus strand

Genomic View for TACSTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACSTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACSTD2 Gene

Regulatory Elements for TACSTD2 Gene

Proteins for TACSTD2 Gene

  • Protein details for TACSTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09758-TACD2_HUMAN
    Recommended name:
    Tumor-associated calcium signal transducer 2
    Protein Accession:
    P09758
    Secondary Accessions:
    • Q15658
    • Q6FG48
    • Q7Z7Q4
    • Q96QD2

    Protein attributes for TACSTD2 Gene

    Size:
    323 amino acids
    Molecular mass:
    35709 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TACSTD2 Gene

neXtProt entry for TACSTD2 Gene

Proteomics data for TACSTD2 Gene at MOPED

Post-translational modifications for TACSTD2 Gene

Other Protein References for TACSTD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TACSTD2 Gene

Domains for TACSTD2 Gene

Protein Domains for TACSTD2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TACD2_HUMAN
Domain:
  • Contains 1 thyroglobulin type-1 domain.:
    • P09758
Family:
  • Belongs to the EPCAM family.:
    • P09758
genes like me logo Genes that share domains with TACSTD2: view

No data available for Gene Families for TACSTD2 Gene

Function for TACSTD2 Gene

Molecular function for TACSTD2 Gene

UniProtKB/Swiss-Prot Function: May function as a growth factor receptor

Gene Ontology (GO) - Molecular Function for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7665234
GO:0005515 protein binding IPI 15607035
genes like me logo Genes that share ontologies with TACSTD2: view
genes like me logo Genes that share phenotypes with TACSTD2: view

Animal Models for TACSTD2 Gene

MGI Knock Outs for TACSTD2:

miRNA for TACSTD2 Gene

miRTarBase miRNAs that target TACSTD2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TACSTD2 Gene

Localization for TACSTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACSTD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACSTD2 Gene COMPARTMENTS Subcellular localization image for TACSTD2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS 10192395
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 7665234
genes like me logo Genes that share ontologies with TACSTD2: view

Pathways for TACSTD2 Gene

SuperPathways for TACSTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TACSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 7665234
GO:0007601 visual perception IEA --
GO:0008283 cell proliferation TAS 7665234
GO:0010633 negative regulation of epithelial cell migration ISS --
GO:0050678 regulation of epithelial cell proliferation IEA --
genes like me logo Genes that share ontologies with TACSTD2: view

No data available for Pathways by source for TACSTD2 Gene

Compounds for TACSTD2 Gene

(3) Novoseek inferred chemical compound relationships for TACSTD2 Gene

Compound -log(P) Hits PubMed IDs
aspartate 9.35 2
calcium 2.1 4
alanine 2.07 2
genes like me logo Genes that share compounds with TACSTD2: view

Transcripts for TACSTD2 Gene

mRNA/cDNA for TACSTD2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(302) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACSTD2 Gene

Tumor-associated calcium signal transducer 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TACSTD2 Gene

No ASD Table

Relevant External Links for TACSTD2 Gene

GeneLoc Exon Structure for
TACSTD2
ECgene alternative splicing isoforms for
TACSTD2

Expression for TACSTD2 Gene

mRNA expression in normal human tissues for TACSTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACSTD2 Gene

This gene is overexpressed in Esophagus - Mucosa (14.5), Minor Salivary Gland (9.4), Skin - Not Sun Exposed (Suprapubic) (5.5), Skin - Sun Exposed (Lower leg) (5.5), and Vagina (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TACSTD2 Gene

SOURCE GeneReport for Unigene cluster for TACSTD2 Gene Hs.23582

mRNA Expression by UniProt/SwissProt for TACSTD2 Gene

P09758-TACD2_HUMAN
Tissue specificity: Placenta, pancreatic carcinoma cell lines
genes like me logo Genes that share expressions with TACSTD2: view

Orthologs for TACSTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TACSTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACSTD2 36
  • 99.78 (n)
  • 100 (a)
TACSTD2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TACSTD2 36
  • 86.31 (n)
  • 80.25 (a)
TACSTD2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACSTD2 36
  • 88.13 (n)
  • 83.56 (a)
mouse
(Mus musculus)
Mammalia Tacstd2 36
  • 81.94 (n)
  • 80.6 (a)
Tacstd2 16
Tacstd2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACSTD2 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacstd2 36
  • 82.22 (n)
  • 81.33 (a)
chicken
(Gallus gallus)
Aves TACSTD2 36
  • 52.41 (n)
  • 46.29 (a)
TACSTD2 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACSTD2 37
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii epcam 37
  • 35 (a)
OneToMany
Species with no ortholog for TACSTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACSTD2 Gene

ENSEMBL:
Gene Tree for TACSTD2 (if available)
TreeFam:
Gene Tree for TACSTD2 (if available)

Paralogs for TACSTD2 Gene

Paralogs for TACSTD2 Gene

Selected SIMAP similar genes for TACSTD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TACSTD2: view

Variants for TACSTD2 Gene

Sequence variations from dbSNP and Humsavar for TACSTD2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1020 -- 58,575,920(-) CAGTG(A/C/T)AGGAA utr-variant-3-prime
rs3551 -- 58,575,905(-) TGGCA(C/T)AGCGT utr-variant-3-prime
rs7333 -- 58,575,548(-) TTACT(A/G)CCACT utr-variant-3-prime
rs9583 -- 58,575,764(-) ATTTG(A/G)TGAGT utr-variant-3-prime
rs13267 -- 58,576,758(-) GGCGT(C/G)CGCCG synonymous-codon, reference

Relevant External Links for TACSTD2 Gene

HapMap Linkage Disequilibrium report
TACSTD2
Human Gene Mutation Database (HGMD)
TACSTD2

No data available for Structural Variations from Database of Genomic Variants (DGV) for TACSTD2 Gene

Disorders for TACSTD2 Gene

(1) OMIM Diseases for TACSTD2 Gene (137290)

UniProtKB/Swiss-Prot

TACD2_HUMAN
  • Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. {ECO:0000269 PubMed:10192395}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for TACSTD2 Gene

(9) Novoseek inferred disease relationships for TACSTD2 Gene

Disease -log(P) Hits PubMed IDs
amyloidosis, corneal 97.3 14
corneal dystrophy 87.9 10
lattice corneal dystrophy 81 1
gastrointestinal carcinoma 64 1
ovarian carcinoma 37.2 1

Relevant External Links for TACSTD2

Genetic Association Database (GAD)
TACSTD2
genes like me logo Genes that share disorders with TACSTD2: view

Publications for TACSTD2 Gene

  1. Retroposition in a family of carcinoma-associated antigen genes. (PMID: 8382772) Linnenbach A.J. … Huebner K. (Mol. Cell. Biol. 1993) 2 3 4 23
  2. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. (PMID: 7665234) Fornaro M. … Alberti S. (Int. J. Cancer 1995) 3 4 23
  3. A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. (PMID: 11687514) Tasa G. … Lang A. (Invest. Ophthalmol. Vis. Sci. 2001) 3 4 23
  4. Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. (PMID: 15013888) Tian X. … Liu Z. (Am. J. Ophthalmol. 2004) 3 23 49
  5. Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy. (PMID: 15295654) Murakami A. … Kanai A. (Jpn. J. Ophthalmol. 2004) 3 23

Products for TACSTD2 Gene

Sources for TACSTD2 Gene

Back to Top

Content