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Aliases for TACR3 Gene

Aliases for TACR3 Gene

  • Tachykinin Receptor 3 2 3 4
  • Neurokinin Beta Receptor 2 3
  • Neurokinin B Receptor 3 4
  • NK-3 Receptor 3 4
  • NK-3R 3 4
  • NK3R 3 4
  • NKR 3 4
  • TAC3RL 3
  • TAC3R 4
  • HH11 3

External Ids for TACR3 Gene

Previous GeneCards Identifiers for TACR3 Gene

  • GC04M104909
  • GC04M104969
  • GC04M104868
  • GC04M104730
  • GC04M104507
  • GC04M100245

Summaries for TACR3 Gene

Entrez Gene Summary for TACR3 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR3 Gene

TACR3 (Tachykinin Receptor 3) is a Protein Coding gene. Diseases associated with TACR3 include tacr3-related isolated gonadotropin-releasing hormone deficiency and hypogonadotropic hypogonadism 11 with or without anosmia. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and tachykinin receptor activity. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for TACR3 Gene

  • This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P

Tocris Summary for TACR3 Gene

  • The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).

Gene Wiki entry for TACR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR3 Gene

Genomics for TACR3 Gene

Regulatory Elements for TACR3 Gene

Genomic Location for TACR3 Gene

Chromosome:
4
Start:
103,586,031 bp from pter
End:
103,719,816 bp from pter
Size:
133,786 bases
Orientation:
Minus strand

Genomic View for TACR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TACR3 Gene

Proteins for TACR3 Gene

  • Protein details for TACR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29371-NK3R_HUMAN
    Recommended name:
    Neuromedin-K receptor
    Protein Accession:
    P29371
    Secondary Accessions:
    • Q0P510

    Protein attributes for TACR3 Gene

    Size:
    465 amino acids
    Molecular mass:
    52202 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR3 Gene

Proteomics data for TACR3 Gene at MOPED

Post-translational modifications for TACR3 Gene

  • The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue
  • Glycosylation at Asn 23, Asn 50, and Asn 73
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR3 Gene

Domains & Families for TACR3 Gene

Gene Families for TACR3 Gene

Suggested Antigen Peptide Sequences for TACR3 Gene

Graphical View of Domain Structure for InterPro Entry

P29371

UniProtKB/Swiss-Prot:

NK3R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR3: view

Function for TACR3 Gene

Molecular function for TACR3 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P

Gene Ontology (GO) - Molecular Function for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004995 tachykinin receptor activity IEA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with TACR3: view
genes like me logo Genes that share phenotypes with TACR3: view

Animal Models for TACR3 Gene

MGI Knock Outs for TACR3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TACR3 Gene

Localization for TACR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACR3 Gene COMPARTMENTS Subcellular localization image for TACR3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1374246
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TACR3: view

Pathways & Interactions for TACR3 Gene

genes like me logo Genes that share pathways with TACR3: view

Pathways by source for TACR3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007217 tachykinin receptor signaling pathway TAS 8990205
GO:0007568 aging IEA --
GO:0010460 positive regulation of heart rate IEA --
GO:0032355 response to estradiol IEA --
genes like me logo Genes that share ontologies with TACR3: view

No data available for SIGNOR curated interactions for TACR3 Gene

Drugs & Compounds for TACR3 Gene

(50) Drugs for TACR3 Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, ApexBio, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 148
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Dopamine Approved Pharma Full agonist, Agonist 2814
Fenoterol Approved Pharma Full agonist, Agonist 14
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97

(18) Additional Compounds for TACR3 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SB 223412
Antagonist 174636-32-9
[<sup>3</sup>H]senktide
[<sup>3</sup>H]SR142,801
Antagonist
N,2-diphenylquinoline-4-carbohydrazide 8m
Antagonist
PD 157672
Antagonist
genes like me logo Genes that share compounds with TACR3: view

Drug Products

Transcripts for TACR3 Gene

mRNA/cDNA for TACR3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR3 Gene

Tachykinin receptor 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR3 Gene

No ASD Table

Relevant External Links for TACR3 Gene

GeneLoc Exon Structure for
TACR3
ECgene alternative splicing isoforms for
TACR3

Expression for TACR3 Gene

mRNA expression in normal human tissues for TACR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR3 Gene

This gene is overexpressed in Bladder (x12.0), Brain - Hypothalamus (x10.9), Brain - Amygdala (x6.7), and Brain - Spinal cord (cervical c-1) (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TACR3 Gene



SOURCE GeneReport for Unigene cluster for TACR3 Gene Hs.942

genes like me logo Genes that share expression patterns with TACR3: view

Protein tissue co-expression partners for TACR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TACR3 Gene

Orthologs for TACR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACR3 35
  • 88.7 (n)
  • 90.5 (a)
TACR3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACR3 35
  • 88.82 (n)
  • 89.54 (a)
TACR3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacr3 35
  • 85.62 (n)
  • 88.5 (a)
Tacr3 16
Tacr3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACR3 35
  • 99.64 (n)
  • 99.78 (a)
TACR3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacr3 35
  • 85.62 (n)
  • 88.72 (a)
oppossum
(Monodelphis domestica)
Mammalia TACR3 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves TACR3 35
  • 78.68 (n)
  • 83.82 (a)
TACR3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr3 35
  • 74.94 (n)
  • 79.54 (a)
zebrafish
(Danio rerio)
Actinopterygii tacr3l 35
  • 66.05 (n)
  • 69.47 (a)
TACR3 (2 of 3) 36
  • 58 (a)
OneToMany
tacr3a 36
  • 65 (a)
OneToMany
tacr3l 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 31 (a)
NepYr 37
  • 34 (a)
Takr86C 37
  • 36 (a)
Takr99D 37
  • 46 (a)
Takr99D 35
  • 53.12 (n)
  • 44.03 (a)
Takr86C 36
  • 26 (a)
ManyToMany
Takr99D 36
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK2 35
  • 52.92 (n)
  • 42.46 (a)
worm
(Caenorhabditis elegans)
Secernentea C49A9.7 37
  • 35 (a)
tkr-1 37
  • 35 (a)
Y59H11AL.1 37
  • 30 (a)
C49A9.7 35
  • 47.83 (n)
  • 38.1 (a)
tkr-1 36
  • 29 (a)
ManyToMany
tkr-2 36
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for TACR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR3 Gene

ENSEMBL:
Gene Tree for TACR3 (if available)
TreeFam:
Gene Tree for TACR3 (if available)

Paralogs for TACR3 Gene

(11) SIMAP similar genes for TACR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TACR3: view

Variants for TACR3 Gene

Sequence variations from dbSNP and Humsavar for TACR3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_049422 -
VAR_049423 -
VAR_069177 Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)
VAR_069178 Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)
VAR_069963 Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)

Structural Variations from Database of Genomic Variants (DGV) for TACR3 Gene

Variant ID Type Subtype PubMed ID
nsv830023 CNV Loss 17160897
nsv879688 CNV Gain 21882294
esv27466 CNV Loss 19812545
esv2665839 CNV Deletion 23128226
esv2658453 CNV Deletion 23128226

Variation tolerance for TACR3 Gene

Residual Variation Intolerance Score: 31.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACR3 Gene

HapMap Linkage Disequilibrium report
TACR3
Human Gene Mutation Database (HGMD)
TACR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR3 Gene

Disorders for TACR3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TACR3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

UniProtKB/Swiss-Prot

NK3R_HUMAN
  • Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:19079066, ECO:0000269 PubMed:23643382, ECO:0000269 PubMed:25077900}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in TACR3 as well as in other HH-associated genes including FGFR1, SPRY4 and KAL1 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Relevant External Links for TACR3

Genetic Association Database (GAD)
TACR3
Human Genome Epidemiology (HuGE) Navigator
TACR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACR3
genes like me logo Genes that share disorders with TACR3: view

No data available for Genatlas for TACR3 Gene

Publications for TACR3 Gene

  1. The effects of neurokinin B upon gonadotrophin release in male rodents. (PMID: 20041982) Corander M.P. … Coll A.P. (J. Neuroendocrinol. 2010) 23 67
  2. Therapeutic utility of NK3 receptor antagonists for the treatment of schizophrenia. (PMID: 20109143) Dawson L.A. … Smith P.W. (Curr. Pharm. Des. 2010) 23 67
  3. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PMID: 19079066) Topaloglu A.K. … Semple R.K. (Nat. Genet. 2009) 23 67
  4. Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3. (PMID: 19426690) Leffler A. … von Mentzer B. (Biochem. Pharmacol. 2009) 23 67
  5. Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. (PMID: 19755480) Guran T. … Topaloglu A.K. (J. Clin. Endocrinol. Metab. 2009) 23 67

Products for TACR3 Gene

Sources for TACR3 Gene

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