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Aliases & Descriptions for TACR3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC148060 2 | | MGC148061 2 | | NK-3R 3 | | NK3R 1, 2, 3, 5 | | NKR 3 | | TAC3R 3 | | TAC3RL 2 |
| | | Descriptions |
|---|
| NK-3 receptor 2, 3 | | Neurokinin B receptor 2, 3 | | neurokinin beta receptor 2 | | tachykinin receptor 3 2, 3 |
|
| | Search outside databases for aliases for TACR3 genePrevious GC identifers: GC04M104909 GC04M104969 GC04M104868 |
Summaries for TACR3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TACR3: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq] UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger systemGene Wiki entry for TACR3 (Tachykinin_receptor_3) |
Genomic Location for TACR3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TACR3 gene 
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q25TACR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M104730:
(about GC identifiers)
Start:
|
104,730,074 bp from pter |
End:
|
104,860,422 bp from pter |
Size:
|
130,349 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for TACR3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371 (See
protein sequence)Recommended Name: Neuromedin-K receptor Size: 465 amino acids; 52202 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P
Secondary accessions: Q0P510Post-translational modifications:
The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue1
REFSEQ proteins: NP_001050.1
ENSEMBL proteins: ENSP00000303325
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TACR3: Assays for TACR3: | Protein
Domains/ Families for TACR3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P29371
ProtoNet protein and cluster: P29371 2 Blocks protein families: IPB001013 Neurokinin NK3 receptor signature IPB001681 Neurokinin receptor signature
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for TACR3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001059
Applied Biosystems Silencer® siRNAs for TACR3
Sigma-Aldrich siRNA and siRNA Panels for TACR3  Sigma-Aldrich shRNA Panels and shRNA for TACR3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001059                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001059                                  untagged cDNA clone in CMV expression vector: NM_001059 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001059
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tacr3):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TACR3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/12 Interacting proteins for TACR3 (ENSP000003033253) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007217 | tachykinin receptor signaling pathway |
TAS | 8990205 | About this table
|
Drugs & Compounds for TACR3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for TACR3 |
 | Sigma-Aldrich Small Molecules for TACR3: Antagonist |
Compounds for TACR3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| SB 222200 | Potent, selective non-peptide NK3 antagonist. Brain penetrant | [174635-69-9] | | SB 218795 | Potent, selective non-peptide NK3 antagonist | [174635-53-1] | | Senktide | Tachykinin NK3 agonist | [106128-89-6] | About this table
10/16 Novoseek chemical compound relationships for TACR3 gene (see all 16
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| senktide |
96.35 |
57 |
8751080 (3), 7530208 (2), 8990205 (2), 15145080 (2) (see all 36) |
| sr48968 |
85.68 |
6 |
8117304 (1), 14718265 (1), 7616392 (1), 9831720 (1) (see all 5) |
| talnetant |
84.36 |
5 |
17728699 (3), 15023866 (1) |
| gr 73632 |
83.71 |
1 |
16077032 (1) |
| eledoisin |
83.31 |
3 |
16127708 (1), 7824047 (1) |
| septide |
82.11 |
2 |
8583573 (1), 9846636 (1) |
| gr 82334 |
77.20 |
1 |
12906840 (1) |
| 5-methoxytryptamine |
43.76 |
1 |
7516254 (1) |
| calcium |
27.07 |
18 |
7530208 (2), 18203813 (2), 15990182 (2), 8648606 (2) (see all 9) |
| nitric oxide |
6.46 |
13 |
8751080 (2), 7691627 (1), 9276151 (1), 8929331 (1) |
About this table
|
Transcripts for TACR3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001059
Sigma-Aldrich siRNA and siRNA Panels for TACR3  Sigma-Aldrich shRNA Panels and shRNA for TACR3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001059 REFSEQ mRNAs for TACR3 gene: NM_001059.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001059               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001059                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001059                                  untagged cDNA clone in CMV expression vector: NM_001059  Additional cDNA sequence: AY462099.1 BC095527.1 BC121806.1 BC122551.1 M89473.1 2 DOTS entries: DT.304094 DT.101980157 3 AceView cDNA sequences:M89473 AL700003 NM_001059
highest scoring ESTs for TACR3:M89473 AY462099 CD246197 CD013878 NM_001059 AL700003 BC095527 BC121806 BC122551 CO960674 Unigene Cluster for TACR3: Tachykinin receptor 3 Hs.942 [show with all ESTs]Unigene Representative Sequence: M89473
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000304883
|
Expression for TACR3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TACR3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TACR3
1 / 2 / 3 3 probe-sets matching TACR3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTAGCCTCCA
SOURCE GeneReport for Unigene cluster: Hs.942
Expression variation in blood from EXPOLDB for TACR3 |
Orthologs for TACR3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TACR3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for TACR3
ENSEMBL Gene Tree for TACR3 | Paralogs for TACR3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TACR3 gene
- TACR22 TACR12
|
SNPs/Variants for TACR3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TACR3 (up to first 250kb)
|
Disorders & Mutations for TACR3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 162332 disorders: 146110 5 Novoseek disease relationships for TACR3 gene
About this table
Human Gene Mutation Database: TACR3 Human Genome Epidemiology Navigator: TACR3 (5 documents)
|
Medical News for TACR3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TACR3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/199 PubMed articles for TACR3 gene (see all 199
):- cDNA sequence and heterologous expression of the human neurokinin-3 receptor. (PubMed id 1374246)2, 3, 4 Huang R.-R.C.... Fong T.M. (1992)
- The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)1, 3, 4 Takahashi K.... Nakanishi S. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Molecular characterisation, expression and localisation of human neurokinin-3 receptor. (PubMed id 1312036)3, 4 Buell G.... Kawashima E. (1992)
- The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (PubMed id 18422838)1, 3 Foroud T....Edenberg H.J. (2008)
- An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. (PubMed id 18287949)1, 3 Saito S....Ozaki N. (2008)
- Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. (PubMed id 8990205)1, 3 Krause J.E....Karpitskiy V.V. (1997)
- TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PubMed id 19079066)1, 3 Topaloglu A.K....Semple R.K. (2009)
- Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. (PubMed id 18203813)1, 3 Mizuta K....Emala C.W. (2008)
- The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. (PubMed id 8702757)1, 3 Tian Y....Chung F.Z. (1996)
|
Search for TACR3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TACR3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TACR3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TACR3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TACR3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TACR3:

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|
 |  |  |
| | | | Tocris compounds for TACR3 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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