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TACR3 Gene

protein-coding   GIFtS: 63

GC04M104730
tachykinin receptor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC148060 2
MGC148061 2
NK-3R 3
NK3R 1, 2, 3, 5
NKR 3
TAC3R 3
TAC3RL 2
Descriptions
NK-3 receptor 2, 3
Neurokinin B receptor 2, 3
neurokinin beta receptor 2
tachykinin receptor 3 2, 3
External Ids
HGNC: 115281
Entrez Gene: 68702
UniProtKB: P293713
Ensembl: ENSG000001698367
Search outside databases for aliases for TACR3 gene

Previous GC identifers: GC04M104909 GC04M104969 GC04M104868

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TACR3:
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor
affinities are specified by variations in the 5'-end of the sequence. The receptors belonging
to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane
regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as
neurokinin B. [provided by RefSeq]

UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371
Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is
associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Wiki entry for TACR3 (Tachykinin_receptor_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TACR3 gene  

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q25

TACR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M104730:     (about GC identifiers)

Start:
104,730,074 bp from pter
End:
104,860,422 bp from pter
Size:
130,349 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371 (See protein sequence)
Recommended Name: Neuromedin-K receptor  
Size: 465 amino acids; 52202 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The rank order of affinity of this receptor to tachykinins is: neuromedin-K >
substance K > substance P
Secondary accessions: Q0P510

Post-translational modifications:

  • The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of
    a cysteine residue1


  • REFSEQ proteins: NP_001050.1  

    ENSEMBL proteins: 
    ENSP00000303325 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Neurokinin 3 Receptor NK3)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS1374246
    About this table

    Antibodies for TACR3: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of TACR3
    Sigma-Aldrich Antibodies for TACR3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Neurokinin 3 Receptor NK3), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for TACR3

    Assays for TACR3: 
    Invitrogen Assays for TACR3
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR001681 Neurokn_rcpt
     IPR001013 NK3_rcpt
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  TACR3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P29371

    ProtoNet protein and cluster: P29371

    2 Blocks protein families:
    IPB001013 Neurokinin NK3 receptor signature
    IPB001681 Neurokinin receptor signature


    UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACR3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACR3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001059

                  Applied Biosystems Silencer® siRNAs for TACR3

                  Sigma-Aldrich siRNA and siRNA Panels for TACR3  
                         Sigma-Aldrich shRNA Panels and shRNA for TACR3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Millipore Clones for the Expression of TACR3
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001059
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001059
                                     untagged cDNA clone in CMV expression vector: NM_001059 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001059

    UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371
    Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is
    associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

    2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tacr3):

    behavior/neurologicalgrowth/size

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0004995 tachykinin receptor activity TAS8990205
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for TACR3
     Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

       GeneDecks  TACR3 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for TACR3):
     hsa04020 Calcium signaling pathway
     hsa04080 Neuroactive ligand-receptor interaction

       GeneDecks  TACR3 for the pathways selected above  
    About GeneDecksing

    5/12 Interacting proteins for TACR3 (ENSP000003033253) via UniProtKB, MINT, and/or STRING (see all 12 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAC3ENSP000003502363STRING (score=.999)
    TAC1ENSP000003211063STRING (score=.993)
    TAC4ENSP000003340423STRING (score=.956)
    FOSENSP000003062453STRING (score=.884)
    NKX2-1ENSP000003539183STRING (score=.868)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007217 tachykinin receptor signaling pathway TAS8990205
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for TACR3
    Sigma-Aldrich Small Molecules for TACR3:
    Antagonist

    Compounds for TACR3 available from Tocris Bioscience
    CompoundAction CAS number
    SB 222200Potent, selective non-peptide NK3 antagonist. Brain penetrant[174635-69-9]
    SB 218795Potent, selective non-peptide NK3 antagonist[174635-53-1]
    SenktideTachykinin NK3 agonist[106128-89-6]
    About this table


    10/16 Novoseek chemical compound relationships for TACR3 gene (see all 16 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    senktide 96.35 57 8751080 (3), 7530208 (2), 8990205 (2), 15145080 (2) (see all 36)
    sr48968 85.68 6 8117304 (1), 14718265 (1), 7616392 (1), 9831720 (1) (see all 5)
    talnetant 84.36 5 17728699 (3), 15023866 (1)
    gr 73632 83.71 1 16077032 (1)
    eledoisin 83.31 3 16127708 (1), 7824047 (1)
    septide 82.11 2 8583573 (1), 9846636 (1)
    gr 82334 77.20 1 12906840 (1)
    5-methoxytryptamine 43.76 1 7516254 (1)
    calcium 27.07 18 7530208 (2), 18203813 (2), 15990182 (2), 8648606 (2) (see all 9)
    nitric oxide 6.46 13 8751080 (2), 7691627 (1), 9276151 (1), 8929331 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACR3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACR3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001059

                  Sigma-Aldrich siRNA and siRNA Panels for TACR3  
                         Sigma-Aldrich shRNA Panels and shRNA for TACR3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001059  

    REFSEQ mRNAs for TACR3 gene: 

    NM_001059.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001059  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001059
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001059
                                     untagged cDNA clone in CMV expression vector: NM_001059 

    Additional cDNA sequence: 

    AY462099.1 BC095527.1 BC121806.1 BC122551.1 M89473.1 

    2 DOTS entries:

    DT.304094  DT.101980157 

    3 AceView cDNA sequences:

    M89473 AL700003 NM_001059 

    highest scoring ESTs for TACR3:

    M89473 AY462099 CD246197 CD013878 NM_001059 AL700003 BC095527 BC121806 BC122551 CO960674 

    Unigene Cluster for TACR3:

    Tachykinin receptor 3
    Hs.942  [show with all ESTs]
    Unigene Representative Sequence: M89473


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000304883  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TACR3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TACR3

    1 / 2 / 3

    3 probe-sets matching TACR3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32446_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M89473 1.00 1.00 1.00 1

    208183_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001059 0.60 1.00 0.82 1

    208183_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTAGCCTCCA

    SOURCE GeneReport for Unigene cluster: Hs.942

    Expression variation in blood from EXPOLDB for TACR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TACR3 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TACR31   -- tachykinin receptor 3 92.02(n)
    94.3(a)
    403814  XM_545007.2  XP_545007.2 
    cow
    (Bos taurus)
    TACR31   -- tachykinin receptor 3 88.7(n)
    90.5(a)
    404136  XM_590375.3  XP_590375.2 
    rat
    (Rattus norvegicus)
    Tacr31   -- tachykinin receptor 3 85.62(n)
    88.72(a)
    24808  NM_017053.1  NP_058749.1 
    mouse
    (Mus musculus)
    Tacr31, 5 35
    tachykinin receptor 31, 5 85.62(n)1
    88.5(a)1
    213381  NM_021382.31  NP_067357.11 
     AF2333415  AK0318985  (see all 9)
    chicken
    (Gallus gallus)
    TACR31   -- tachykinin receptor 3 75.99(n)
    79.82(a)
    768993  XM_001232173.1  XP_001232174.1 
    About this table        Species with no ortholog for TACR3

    ENSEMBL Gene Tree for TACR3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TACR3 gene
    TACR22  TACR12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/750 NCBI SNPs in TACR3 are shown (see all 750 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 205)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs27651,2
    A,C,F,H,O104730215(+) GACTGA/GTAAAT 1 -- ut31 ese316Minor allele frequency- T:0.02MN NA EU EA WA 1606
    rs37336321,2
    A,C,F,H104860384(-) AAGACT/CCCGGC 1 -- ut51 ese35Minor allele frequency- C:0.40EA EU WA 1912
    rs37336311,2
    A,C,F,H104860552(-) CCCTAC/GGTGTG 1 -- ng315Minor allele frequency- G:0.40EA EU WA 1916
    rs37759711,2
    A,C,F,H104861369(-) CATATA/GTCCAG 1 -- ng3117Minor allele frequency- N:0.00EA NA EU WA 2928
    rs170340171,2
    C,F,H104861313(+) CCTGGG/ATTGAA 1 -- ng3111Minor allele frequency- A:0.06NA EU EA WA 976
    rs22769731,2
    C,F,H104796831(-) TGACAA/GGTATC 1 K/R mis1 ese310Minor allele frequency- G:0.02EU EA WA NA 1086
    rs131482291,2
    C,F,H104729882(+) TTTTAT/CACAGA 1 -- ng518Minor allele frequency- C:0.04NA EU EA WA 748
    --
    rs170338891,2
    C,F,H104730341(-) CCTCCG/ACCACT 1 T/A mis1 ese35Minor allele frequency- A:0.01EU EA WA 586
    rs345502111,2
    F104732257(+) GCAAAT/GGTCAT 1 T/T syn11Minor allele frequency- G:0.03NA 78
    rs350859191,2
    F104796815(+) GCCTTT/CAGCTG 1 L/L syn11Minor allele frequency- C:0.04NA 68
    About this table

    HapMap Linkage Disequilibrium images for TACR3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 162332   disorders: 146110  

    5 Novoseek disease relationships for TACR3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 43.70 1 7679031 (1)
    motility disorder 19.28 1 15023866 (1)
    preeclampsia 5.24 2 12783571 (1), 16709596 (1)
    psychiatric disorder 0.00 2 17728699 (1)
    schizophrenia 0.00 4 18287949 (2), 16918327 (1)
    About this table

    Human Gene Mutation Database: TACR3
    Human Genome Epidemiology Navigator: TACR3 (5 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/199 PubMed articles for TACR3 gene (see all 199 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 6870 HGNC: 11528 AceView: TACR3 Ensembl:ENSG00000169836 euGenes: HUgn6870
    ECgene: TACR3 H-InvDB: TACR3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TACR3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TACR3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TACR3 Antibodies for TACR3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TACR3 Small molecules for TACR3
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (Neurokinin 3 Receptor NK3)
     Antibodies (Neurokinin 3 Receptor NK3)
     Search OriGene for TACR3
     Tocris compounds for TACR3




     Drugs for TACR3
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TACR3

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