Aliases for TACR3 Gene
External Ids for TACR3 Gene
Previous GeneCards Identifiers for TACR3 Gene
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACR3 Gene
TACR3 (Tachykinin Receptor 3) is a Protein Coding gene. Diseases associated with TACR3 include tacr3-related isolated gonadotropin-releasing hormone deficiency and hypogonadotropic hypogonadism 11 with or without anosmia. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and tachykinin receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for TACR3 Gene
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P
The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).