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Aliases for TACR3 Gene

Aliases for TACR3 Gene

  • Tachykinin Receptor 3 2 3 4 5
  • Neurokinin Beta Receptor 2 3
  • Neurokinin B Receptor 3 4
  • NK-3 Receptor 3 4
  • NK-3R 3 4
  • NK3R 3 4
  • NKR 3 4
  • Neuromedin-K Receptor 3
  • TAC3RL 3
  • TAC3R 4
  • HH11 3

External Ids for TACR3 Gene

Previous GeneCards Identifiers for TACR3 Gene

  • GC04M104909
  • GC04M104969
  • GC04M104868
  • GC04M104730
  • GC04M104507
  • GC04M100245

Summaries for TACR3 Gene

Entrez Gene Summary for TACR3 Gene

  • This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACR3 Gene

TACR3 (Tachykinin Receptor 3) is a Protein Coding gene. Diseases associated with TACR3 include Hypogonadotropic Hypogonadism 11 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and tachykinin receptor activity. An important paralog of this gene is TACR1.

UniProtKB/Swiss-Prot for TACR3 Gene

  • This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Tocris Summary for TACR3 Gene

  • The neurokinin 3 (NK3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).

Gene Wiki entry for TACR3 Gene

Additional gene information for TACR3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR3 Gene

Genomics for TACR3 Gene

GeneHancer (GH) Regulatory Elements for TACR3 Gene

Promoters and enhancers for TACR3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I103718 Enhancer 0.6 Ensembl ENCODE 560.5 +0.2 183 2.2 CTCF EZH2 TACR3 GC04M103656
GH04I103754 Enhancer 0.6 ENCODE 11.9 -35.1 -35094 1 CTCF JUN HLF MAX CEBPB EP300 NFIL3 MAFF NFE2 MAFK TACR3 RNU6-635P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TACR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TACR3 gene promoter:

Genomic Locations for TACR3 Gene

Genomic Locations for TACR3 Gene
133,786 bases
Minus strand

Genomic View for TACR3 Gene

Genes around TACR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR3 Gene

Proteins for TACR3 Gene

  • Protein details for TACR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuromedin-K receptor
    Protein Accession:
    Secondary Accessions:
    • Q0P510

    Protein attributes for TACR3 Gene

    465 amino acids
    Molecular mass:
    52202 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACR3 Gene

Post-translational modifications for TACR3 Gene

  • The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
  • Glycosylation at posLast=2323, posLast=5050, and isoforms=73

Other Protein References for TACR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TACR3 Gene

Domains & Families for TACR3 Gene

Gene Families for TACR3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TACR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR3: view

Function for TACR3 Gene

Molecular function for TACR3 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Phenotypes From GWAS Catalog for TACR3 Gene

Gene Ontology (GO) - Molecular Function for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004995 tachykinin receptor activity IEA,TAS --
GO:0005515 protein binding IPI 12716968
genes like me logo Genes that share ontologies with TACR3: view
genes like me logo Genes that share phenotypes with TACR3: view

Human Phenotype Ontology for TACR3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TACR3 Gene

MGI Knock Outs for TACR3:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TACR3 Gene

Localization for TACR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACR3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 1
endosome 1

Gene Ontology (GO) - Cellular Components for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1374246
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TACR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TACR3 Gene

Pathways & Interactions for TACR3 Gene

genes like me logo Genes that share pathways with TACR3: view

Gene Ontology (GO) - Biological Process for TACR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007217 tachykinin receptor signaling pathway TAS 8990205
GO:0007568 aging IEA --
GO:0010460 positive regulation of heart rate IEA --
genes like me logo Genes that share ontologies with TACR3: view

No data available for SIGNOR curated interactions for TACR3 Gene

Drugs & Compounds for TACR3 Gene

(61) Drugs for TACR3 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 160
Osanetant Investigational Pharma Antagonist, Target, antagonist 0
Substance P Investigational Pharma Full agonist, Agonist 256
Senktide Pharma Full agonist, Agonist Tachykinin NK3 agonist 0

(13) Additional Compounds for TACR3 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SB 223412
Antagonist 174636-32-9
N,2-diphenylquinoline-4-carbohydrazide 8m
PD 157672

(5) Tocris Compounds for TACR3 Gene

Compound Action Cas Number
SB 218795 Potent, selective non-peptide NK3 antagonist 174635-53-1
SB 222200 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174635-69-9
SB 223412 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174636-32-9
Senktide Tachykinin NK3 agonist 106128-89-6
SSR 146977 hydrochloride Potent and selective NK3 antagonist 264618-38-4

(14) ApexBio Compounds for TACR3 Gene

Compound Action Cas Number
Antagonist G 115150-59-9
Eledoisin-Related Peptide 2990-43-4
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
Locustatachykinin I 126985-97-5
Neurokinin A (porcine) 86933-74-6
Neurokinin B (human, porcine) 86933-75-7
SB 218795 174635-53-1
SB-222200 Human NK-3 receptor antagonist 174635-69-9
Senktide 106128-89-6
SSR 146977 hydrochloride 264618-38-4
Substance P 33507-63-0
Talnetant NK3 receptor antagonist,potent and selective 174636-32-9
Talnetant hydrochloride NK3 receptor antagonist 204519-66-4
genes like me logo Genes that share compounds with TACR3: view

Drug Products

Transcripts for TACR3 Gene

mRNA/cDNA for TACR3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR3 Gene

Tachykinin receptor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR3 Gene

No ASD Table

Relevant External Links for TACR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TACR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TACR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR3 Gene

This gene is overexpressed in Bladder (x12.0), Brain - Hypothalamus (x10.9), Brain - Amygdala (x6.7), and Brain - Spinal cord (cervical c-1) (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TACR3 Gene

Protein tissue co-expression partners for TACR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TACR3 Gene:


SOURCE GeneReport for Unigene cluster for TACR3 Gene:


Evidence on tissue expression from TISSUES for TACR3 Gene

  • Nervous system(4.6)
  • Muscle(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TACR3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • face
  • head
  • hypothalamus
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • olfactory bulb
  • pharynx
  • pituitary gland
  • skull
  • vocal cord
  • breast
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • kidney
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vas deferens
  • vulva
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • hair
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with TACR3: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TACR3 Gene

Orthologs for TACR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TACR3 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia TACR3 33 34
  • 88.82 (n)
(Bos Taurus)
Mammalia TACR3 34 33
  • 88.7 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
-- 34
  • 72 (a)
(Mus musculus)
Mammalia Tacr3 33 16 34
  • 85.62 (n)
(Rattus norvegicus)
Mammalia Tacr3 33
  • 85.62 (n)
(Monodelphis domestica)
Mammalia TACR3 34
  • 81 (a)
(Gallus gallus)
Aves TACR3 33 34
  • 78.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr3 33
  • 74.94 (n)
(Danio rerio)
Actinopterygii tacr3l 33 34
  • 66.05 (n)
tacr3a 34
  • 65 (a)
TACR3 (2 of 3) 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Takr99D 35 33 34
  • 53.12 (n)
Takr86C 35 34
  • 36 (a)
NepYr 35
  • 34 (a)
CG10626 35
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTAK2 33
  • 52.92 (n)
(Caenorhabditis elegans)
Secernentea C49A9.7 35 33
  • 47.83 (n)
tkr-2 34
  • 32 (a)
Y59H11AL.1 35
  • 30 (a)
tkr-1 34 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for TACR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR3 Gene

Gene Tree for TACR3 (if available)
Gene Tree for TACR3 (if available)

Paralogs for TACR3 Gene

Paralogs for TACR3 Gene

(11) SIMAP similar genes for TACR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TACR3: view

Variants for TACR3 Gene

Sequence variations from dbSNP and Humsavar for TACR3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs121918124 pathogenic, not-provided, Hypogonadotropic hypogonadism 11 with or without anosmia, not provided, Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840] 103,719,398(-) C/G/T coding_sequence_variant, missense_variant
rs121918125 pathogenic, not-provided, Hypogonadotropic hypogonadism 11 with or without anosmia, not provided, Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840] 103,591,515(-) G/A coding_sequence_variant, missense_variant
rs138661164 uncertain-significance, Isolated GnRH Deficiency 103,589,790(-) C/T coding_sequence_variant, synonymous_variant
rs143073792 uncertain-significance, likely-benign, Isolated GnRH Deficiency, not specified 103,589,834(-) T/A coding_sequence_variant, missense_variant
rs144292455 pathogenic, likely-pathogenic, Hypogonadotropic hypogonadism 11 with or without anosmia, Isolated GnRH Deficiency 103,656,258(-) C/T coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for TACR3 Gene

Variant ID Type Subtype PubMed ID
esv2658453 CNV deletion 23128226
esv2665839 CNV deletion 23128226
esv27466 CNV loss 19812545
esv2763383 CNV gain 21179565
esv3569640 CNV loss 25503493
esv3601632 CNV loss 21293372
esv3601633 CNV gain 21293372
esv3601634 CNV loss 21293372
esv3601635 CNV loss 21293372
nsv1000196 CNV loss 25217958
nsv1015023 CNV gain 25217958
nsv1073363 CNV deletion 25765185
nsv1129730 CNV tandem duplication 24896259
nsv1142402 CNV tandem duplication 24896259
nsv594985 CNV loss 21841781
nsv830023 CNV loss 17160897
nsv956426 CNV deletion 24416366

Variation tolerance for TACR3 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TACR3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR3 Gene

Disorders for TACR3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TACR3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 11 with or without anosmia
  • hh11
normosmic congenital hypogonadotropic hypogonadism
  • isolated congenital gonadotropin deficiency
kallmann syndrome
  • familial hypogonadism with anosmia
hypogonadotropic hypogonadism
  • congenital idiopathic hypogonadotropic hypogonadism
- elite association - COSMIC cancer census association via MalaCards
Search TACR3 in MalaCards View complete list of genes associated with diseases


  • Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:19079066, ECO:0000269 PubMed:23643382, ECO:0000269 PubMed:25077900}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in TACR3 as well as in other HH-associated genes including FGFR1, SPRY4 and KAL1 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Additional Disease Information for TACR3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TACR3: view

No data available for Genatlas for TACR3 Gene

Publications for TACR3 Gene

  1. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PMID: 19079066) Topaloglu AK … Semple RK (Nature genetics 2009) 3 4 22 58
  2. An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. (PMID: 18287949) Saito S … Ozaki N (Neuroreport 2008) 3 22 44 58
  3. The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (PMID: 18422838) Foroud T … Edenberg HJ (Alcoholism, clinical and experimental research 2008) 3 22 44 58
  4. cDNA sequence and heterologous expression of the human neurokinin-3 receptor. (PMID: 1374246) Huang RR … Fong TM (Biochemical and biophysical research communications 1992) 2 3 4 58
  5. The primary structure and gene organization of human substance P and neuromedin K receptors. (PMID: 1312928) Takahashi K … Nakanishi S (European journal of biochemistry 1992) 3 4 22 58

Products for TACR3 Gene

  • Addgene plasmids for TACR3

Sources for TACR3 Gene

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