Aliases for TACR3 Gene
External Ids for TACR3 Gene
Previous GeneCards Identifiers for TACR3 Gene
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
GeneCards Summary for TACR3 Gene
TACR3 (Tachykinin Receptor 3) is a Protein Coding gene. Diseases associated with TACR3 include hypogonadotropic hypogonadism 11 with or without anosmia and tacr3-related isolated gonadotropin-releasing hormone deficiency. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include tachykinin receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for TACR3 Gene
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P
The neurokinin (NK) 3 receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery. NK3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P (NKB > NKA > SP). The human gene encoding the NK3 receptor has been localized on chromosome 4 (4q25).