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TACR2 Gene

protein-coding   GIFtS: 65
GCID: GC10M071163

Tachykinin Receptor 2


(Previous symbols: TAC2R, NKNAR)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tachykinin Receptor 21 2 3     SKR2 3
NKNAR1 2 3 5     NK-2 Receptor2 3
TAC2R1 2 3 5     Neurokinin 2 Receptor2
Neurokinin A Receptor2 3     Seven Transmembrane Helix Receptor2
NK-2R2 3     Substance K Receptor2
NK2R2 3     Substance-K Receptor2

External Ids:    HGNC: 115271   Entrez Gene: 68652   Ensembl: ENSG000000750737   OMIM: 1623215   UniProtKB: P214523   

Export aliases for TACR2 gene to outside databases

Previous GC identifers: GC10M069975 GC10M070250 GC10M071056 GC10M070509 GC10M070834 GC10M065163


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TACR2 Gene:
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are
specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized
by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the
tachykinin neuropeptide substance K, also referred to as neurokinin A. (provided by RefSeq, Jul 2008)

GeneCards Summary for TACR2 Gene:
TACR2 (tachykinin receptor 2) is a protein-coding gene. GO annotations related to this gene include substance K receptor activity and tachykinin receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NK2R_HUMAN, P21452
Function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G
proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
receptor to tachykinins is: substance K > neuromedin-K > substance P

summary for TACR2 Gene:
The neurokinin (NK) 2 receptor is a member of the tachykinin family of G-protein-coupled receptors which
also includes NK1 and NK3 receptors. The NK2 receptor is predominantly expressed in the periphery
(inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle) with limited expression in
the CNS. NK2 receptors are thought to mediate mood control, gastrointestinal contraction and airway and lung
function. The receptor displays greater potency for the endogenous agonist neurokinin A than neurokinin B
and substance P (NKA > NKB > SP). The human gene encoding the NK2 receptor has been localized on chromosome
10 (10pter-q23).

Gene Wiki entry for TACR2 (Tachykinin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TACR2 gene promoter:
         SRF   SRF (504 AA)   CUTL1   HNF-4alpha1   E47   GATA-1   AREB6   c-Myb   Hand1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTACR2 promoter sequence
   Search Chromatin IP Primers for TACR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TACR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

TACR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACR2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071163:  view genomic region     (about GC identifiers)

Start:
71,163,659 bp from pter      End:
71,176,674 bp from pter
Size:
13,016 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NK2R_HUMAN, P21452 (See protein sequence)
Recommended Name: Substance-K receptor  
Size: 398 amino acids; 44442 Da
Secondary accessions: A8K7I1 Q4QRI5 Q8NGQ8 Q9UDE6 Q9UDE7

Explore the universe of human proteins at neXtProt for TACR2: NX_P21452

Explore proteomics data for TACR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn11, Asn19

  • See TACR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001048.2  
    ENSEMBL proteins: 
     ENSP00000362404   ENSP00000362403  
    Reactome Protein details: P21452

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TACR: GPCR / Class A : Tachykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NK2 receptor
    Tachykinin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001681 Neurokn_rcpt
     IPR000913 NK2_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21452

    ProtoNet protein and cluster: P21452

    2 Blocks protein domains:
    IPB000913 Neurokinin NK2 receptor signature
    IPB001681 Neurokinin receptor signature


    UniProtKB/Swiss-Prot: NK2R_HUMAN, P21452
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with TACR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NK2R_HUMAN, P21452
    Function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G
    proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
    receptor to tachykinins is: substance K > neuromedin-K > substance P

         Genatlas biochemistry entry for TACR2:
    tachykinin 2 receptor,neurokinin A receptor (substance K), G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004995tachykinin receptor activity TAS8307161
    GO:0005515protein binding IPI--
    GO:0016497substance K receptor activity IEA--
         
    Find genes that share ontologies with TACR2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TACR2
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    miRNA
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    miRTarBase miRNAs that target TACR2:
    hsa-mir-335-5p (MIRT017841)

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    1 qRT-PCR Assays for microRNA that regulate TACR2:
    hsa-miR-3127-5p
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TACR2 (NM_001057)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NK2R_HUMAN, P21452: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2173708
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TACR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TACR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    Tachykinin receptors bind tachykinins0.00
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Calcium signaling pathway
    Calcium signaling pathway


    Find genes that share SuperPaths with TACR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TACR2
        Peptide GPCRs

    2 Reactome Pathways for TACR2
        Tachykinin receptors bind tachykinins
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for TACR2):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TACR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TACR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TACR2 (P214521, 3 ENSP000003624034) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAC1P203661, 3, ENSP000003211064EBI-6655413,EBI-6655449 I2D: score=2 STRING: ENSP00000321106
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    TAC3Q9UHF03, ENSP000003001084I2D: score=1 STRING: ENSP00000300108
    TAC4Q86UU93, ENSP000003340424I2D: score=1 STRING: ENSP00000334042
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS2173708
    GO:0006950response to stress ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007217tachykinin receptor signaling pathway TAS8307161
    GO:0007588excretion TAS10862829

    Find genes that share ontologies with TACR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TACR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MEN 10376 Potent, selective NK2 antagonist [135306-85-3]
    GR 64349 Potent, selective NK2 agonist [137593-52-3]
    GR 159897 Non-peptide, potent NK2 antagonist [158848-32-9]
    [Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist[137565-28-7]
    GR 94800 Potent, selective NK2 antagonist [141636-65-9]

    1 HMDB Compound for TACR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for TACR2 (NK2 receptor) (see all 26)    About this table
    LigandTypeActionAffinityPubmed IDs
    MEN 15596
    AntagonistAntagonist9.8 - 10.316979621
    YM44781
    AntagonistAntagonist9.911937780
    GR94800
    AntagonistAntagonist9.88027981
    saredutant
    AntagonistAntagonist9.4 - 9.712206858 9190866 7682062
    GR159897
    AntagonistAntagonist7.8 - 9.57562907 7713168 7682062
    SCH 206272
    AntagonistAntagonist9.412206858
    MEN10627
    AntagonistAntagonist9.2--
    neurokinin A
    AgonistFull agonist8 - 9.111786503 9190866 7682062 11137709
    SB 414240
    AntagonistAntagonist911356103
    nepadutant
    AntagonistAntagonist8.5 - 8.79484857 16979621

    Selected Novoseek inferred chemical compound relationships for TACR2 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    senktide 92.3 12 8751080 (2), 9422808 (2), 7544197 (1), 7530573 (1) (see all 10)
    sr48968 91.5 16 12906840 (1), 15191205 (1), 9778489 (1), 10849478 (1) (see all 14)
    cyclo(gln-trp-phe-gly-leu-met) 91.1 4 7544197 (1), 1964226 (1), 8161607 (1), 7705977 (1)
    gr 71251 90 1 7688874 (1)
    nepadutant 88.7 4 16616700 (2), 19218528 (1), 12917772 (1)
    men 10376 88.5 2 9641542 (1), 16554357 (1)
    cyclo(met-asp-trp-phe-dap-leu)cyclo(2beta-5beta) 85.4 1 7737306 (1)
    septide 85.3 3 7685292 (1), 9422808 (1), 7518302 (1)
    fk 224 84.3 9 8665034 (2), 7543746 (1), 7889271 (1), 7531648 (1) (see all 5)
    thiorphan 81.9 2 17028311 (1)



    Find genes that share compounds with TACR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TACR2 gene: 
    NM_001057.2  

    Unigene Cluster for TACR2:

    Tachykinin receptor 2
    Hs.88372  [show with all ESTs]
    Unigene Representative Sequence: NM_001057
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373307(uc001jpm.2) ENST00000373306(uc001jpn.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TACR2
      QuantiFast Probe-based Assays in human, mouse, rat TACR2

    Additional mRNA sequence: 

    AK096906.1 AK291996.1 AK300649.1 AY322545.1 BC033742.1 BC096842.1 FJ200479.1 M57414.1 

    2 DOTS entries:

    DT.100642718  DT.75101841 

    Selected AceView cDNA sequences (see all 32):

    AY322545 AI971217 BF064138 BQ020625 AW080614 AK096906 AW135753 BX483562 
    AI421049 AW137396 AI494107 BX483631 BX483277 BX483630 M57414 BE790440 
    AI224121 CD610397 BM906753 BV206319 BC033742 CF147817 BI765515 BX280340 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TACR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCAGAAC
    TACR2 Expression
    About this image


    TACR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TACR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TACR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88372
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TACR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TACR2
    OriGene qSTAR qPCR primer pairs in human, mouse for TACR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TACR2
    QuantiTect SYBR Green Assays in human, mouse, rat TACR2
    QuantiFast Probe-based Assays in human, mouse, rat TACR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TACR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacr21 , 5 tachykinin receptor 21, 5 85.09(n)1
    86.05(a)1
      10 (32.37 cM)5
    213371  NM_009314.41  NP_033340.31 
     622524385 
    chicken
    (Gallus gallus)
    Aves TACR21 tachykinin receptor 2 67.82(n)
    65.13(a)
      768996  XM_004942006.1  XP_004942063.1 
    lizard
    (Anolis carolinensis)
    Reptilia TACR26
    tachykinin receptor 2
    50(a)
    1 ↔ 1
    GL343215.1(2186380-2210989)
    zebrafish
    (Danio rerio)
    Actinopterygii tacr21 tachykinin receptor 2 61.04(n)
    56.4(a)
      100002125  XM_001341945.2  XP_001341981.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Takr99D3
    Takr86C1
    G-protein coupled receptor protein
    signaling pathway more3
    Tachykinin-like receptor at 86C1
    37(a)
    (best of 4)3
    50.67(n)1
    38.29(a)1
      412861  NM_079580.31  NP_524304.21 
    worm
    (Caenorhabditis elegans)
    Secernentea tkr-13 G protein coupled receptor 33(a)
    (best of 3)
      III(9457359-9458961)   --


    ENSEMBL Gene Tree for TACR2 (if available)
    TreeFam Gene Tree for TACR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TACR2 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR12  TACR32  
    NPY1R2  NPY2R2  NPFFR12  QRFPR2  HCRTR12  
    6 SIMAP similar genes for TACR2 using alignment to 2 protein entries:     NK2R_HUMAN (see all proteins):
    TACR1    TACR3    PRLHR    hA2aR    GPR83    NPY2R

    Find genes that share paralogs with TACR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TACR2 (see all 622)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790965761,2
    C--71163611(+) ACTTAC/TGCAAA 1 -- ds50010--------
    rs1131878531,2
    F--71163617(+) GCAAAC/GTTTAT 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs122447231,2
    C,F,H--71163727(+) CCCATT/CATCAT 1 -- ds5001 ese318Minor allele frequency- C:0.10NS EA NA WA CSA 2220
    rs1922326851,2
    --71163740(+) GGCAAC/TGTTTG 1 -- ds50010--------
    rs412796661,2
    C,F--71163769(+) TTGTCC/GCCTTT 1 -- ds50013Minor allele frequency- G:0.11WA EA 240
    rs1158973511,2
    C,F--71163779(+) TGAATG/ACCTGT 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs774244601,2
    C,F--71163805(+) ATGGCC/TCCCAC 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1842216381,2
    --71163806(+) TGGCCC/TCCACC 1 -- ds50010--------
    rs118154131,2
    C,F,H--71163882(+) CTTTTA/G/TTACAT 1 -- ds5001 ese36NA WA CSA EA 245
    rs1512218021,2
    C--71163913(+) GGCATC/TTGAGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TACR2 (71163659 - 71176674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TACR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895696CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TACR2
    DNA2.0 Custom Variant and Variant Library Synthesis for TACR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162321    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TACR2:
    Asthma

    Find genes that share disorders with TACR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TACR2 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 43.9 11 9875470 (1), 9223001 (1), 8627566 (1), 15992015 (1) (see all 8)
    airways disease 30.3 1 7891319 (1)
    inflammation 21.3 8 15037522 (2), 11712745 (2), 8529964 (1), 8552786 (1) (see all 6)
    erythroleukemia 6.82 2 8302285 (2)
    hyperalgesia 4.6 1 15037522 (1)
    tumors 0.46 3 11384204 (1), 16222150 (1), 19111017 (1)
    inflammatory bowel diseases 0 1 11073811 (1)
    necrosis 0 2 11384204 (1), 19111017 (1)
    lung diseases 0 1 1281723 (1)
    allergic reaction 0 1 8821532 (1)

    Genetic Association Database (GAD): TACR2
    Human Genome Epidemiology (HuGE) Navigator: TACR2 (11 documents)

    Export disorders for TACR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TACR2 gene, integrated from 10 sources (see all 324):
    (articles sorted by number of sources associating them with TACR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. (PubMed id 1848773)1, 2, 9 Kris R.M.... Schlessinger J. (Cell Growth Differ. 1991)
    2. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PubMed id 16893949)1, 4, 9 Park H.K....Kim Y.Y. (Thorax 2006)
    3. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. (PubMed id 2173708)1, 2, 9 Gerard N.P.... Gerard C. (J. Biol. Chem. 1990)
    4. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. (PubMed id 19583679)1, 4, 9 Kim T.B....Kim Y.Y. (J Clin Pharm Ther 2009)
    5. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of the cDNA from tracheal and gastric tissues. (PubMed id 1845990)1, 2, 9 Gerard N.P....Gerard C. (J. Biol. Chem. 1991)
    6. No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. (PubMed id 19375820)1, 4 Friedrich P....Riemenschneider M. (Neurobiol. Aging 2011)
    7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Pharmacogenetic study of the effects of NK2R G231E G&gt;A and TBX21 H33Q C&gt;G polymorphisms on asthma control with inhaled corticosteroid treatment. (PubMed id 20175803)1, 4 Ye Y.M....Park H.S. (J Clin Pharm Ther 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6865 HGNC: 11527 AceView: TACR2 Ensembl:ENSG00000075073 euGenes: HUgn6865
    ECgene: TACR2 Kegg: 6865 H-InvDB: TACR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TACR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TACR2 gene:
    Search GeneIP for patents involving TACR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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