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TACR1 Gene

protein-coding GIFtS: 63

GC02M075187

tachykinin receptor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TAC1R)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NK-1R ^³
NK1R ^¹, ², ³, ⁵
NKIR ^¹, ²
SPR ^¹, ², ³
TAC1R ^², ³, ⁵

Descriptions
NK-1 receptor ^², ³
neurokinin 1 receptor ^²
tachykinin 1 receptor (substance P receptor, neurokinin 1 receptor) ^²
tachykinin receptor 1 ^², ³
tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) ^²

External Ids
HGNC: 11526¹
Entrez Gene: 6869²
UniProtKB: P25103³
Ensembl: ENSG00000115353⁷

Search outside databases for aliases for TACR1 gene

Previous GC identifers: GC02M075413 GC02M075233 GC02M075250

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TACR1:

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are

characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions.

This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1.

The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of

substance P. [provided by RefSeq]

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated

with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank

order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Gene Wiki entry for TACR1 (Tachykinin_receptor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TACR1 gene

Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1-p12

TACR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M075187: (about GC identifiers)

Start:	75,129,738 bp from pter
End:	75,280,122 bp from pter
Size:	150,385 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103 (See protein sequence)

Recommended Name: Substance-P receptor

Size: 407 amino acids; 46251 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

REFSEQ proteins (2 alternative transcripts):

NP_001049.1 NP_056542.1

ENSEMBL proteins:

ENSP00000303522 ENSP00000386448

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant TACR1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Neurokinin 1 Receptor)
	Human Recombinant Proteins from Abnova (TACR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	10611312
GO:0005887	integral to plasma membrane	TAS	1657150

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Antibodies for TACR1:

	Invitrogen Antibodies for TACR1
	Millipore Mono- and Polyclonal Antibodies for the study of TACR1
	Sigma-Aldrich Antibody Arrays and Antibodies for TACR1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Neurokinin 1 Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TACR1)
	Novus Biologicals Antibody for NK1R

Assays for TACR1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P25103

ProtoNet protein and cluster: P25103

2 Blocks protein families:

IPB000046 Neurokinin NK1 receptor signature

IPB001681 Neurokinin receptor signature

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TACR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001058

Applied Biosystems Silencer® siRNAs for TACR1

Sigma-Aldrich siRNA and siRNA Panels for TACR1

Sigma-Aldrich shRNA Panels and shRNA for TACR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TACR1
		Millipore Clones for the Expression of TACR1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001058
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001058
untagged cDNA clones in CMV expression vector (see all 2): NM_001058

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001058

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated

with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank

order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K

Genatlas biochemistry entry for TACR1:

tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor

superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal

immunomodulation

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tacr1):

	behavior/neurological	homeostasis/metabolism	immune system	nervous system
respiratory system	skeleton	touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004995	tachykinin receptor activity	TAS	8985172
GO:0005515	protein binding	IPI	17986524

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TACR1 (Your Favorite Gene powered by Ingenuity)

Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks TACR1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TACR1

5/22 Interacting proteins for TACR1 (ENSP00000303522³) via UniProtKB, MINT, and/or STRING (see all 22 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAC1	ENSP00000321106³	STRING (score=.999)
TAC3	ENSP00000350236³	STRING (score=.987)
B3GAT1	ENSP00000307875³	STRING (score=.982)
TAC4	ENSP00000334042³	STRING (score=.976)
GNAQ	ENSP00000286548³	STRING (score=.875)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	10854844
GO:0007165	signal transduction	IEA	--
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	1657150
GO:0007217	tachykinin receptor signaling pathway	TAS	8985172
GO:0007638	mechanosensory behavior	TAS	9537323

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for TACR1

Sigma-Aldrich Small Molecules for TACR1:

Antagonist

Compounds for TACR1 available from Tocris Bioscience

Compound	Action	CAS number
RP 67580	Potent and selective NK1 antagonist	[135911-02-3]
L-733,060 hydrochloride	Potent NK1 antagonist	[148700-85-0]
L-732,138	Potent, selective NK1 antagonist	[148451-96-1]
[Sar9,Met(O2)11]-Substance P	Potent, selective NK1 agonist
FK 888	High affinity NK1 receptor antagonist	[138449-07-7]

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10/51 Novoseek chemical compound relationships for TACR1 gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
septide	91.23	54	10051129 (4), 8985159 (3), 7685292 (2), 7891319 (2) (see all 25)
fk 888	87.58	17	7531648 (4), 7504102 (2), 7516885 (2), 9399104 (1) (see all 9)
senktide	85.99	12	9402049 (1), 15145080 (1), 7538871 (1), 8583573 (1) (see all 11)
ly303870	82.15	5	7473161 (5)
gr 82334	81.98	5	7538871 (1), 7679029 (1), 7823080 (1), 7679026 (1) (see all 5)
fk 224	81.53	4	7504102 (1), 8529964 (1), 8821532 (1), 7889271 (1)
ezlopitant	80.77	5	11030465 (1), 11092597 (1), 17431029 (1), 12184141 (1) (see all 5)
rpr 100893	80.46	1	9443945 (1)
eledoisin	78.13	5	1711392 (1), 1281775 (1), 1708071 (1), 16127708 (1)
gr 73632	76.68	3	7538871 (1), 16077032 (1), 7679026 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TACR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001058

Sigma-Aldrich siRNA and siRNA Panels for TACR1

Sigma-Aldrich shRNA Panels and shRNA for TACR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001058 NM_015727

REFSEQ mRNAs for TACR1 gene (2 alternative transcripts):

NM_001058.3 NM_015727.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001058 NM_015727

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001058
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001058
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001058

Additional cDNA sequence:

AK289765.1 AY462098.1 BC074911.2 BC074912.2 BC095528.1 M74290.1 M76675.1 M81797.1

M84425.1 M84426.1 S62045.1

5 DOTS entries:

DT.309603 DT.70105091 DT.100742331 DT.432141 DT.95093567

13 AceView cDNA sequences:

AY462098 CD246198 M84425 NM_015727 NM_001058 BC074912 M74290 BC074911

M81797 M76675 S62045 M84426 AL120339

highest scoring ESTs for TACR1:

M74290 AY462098 BE765394 CD246198 M76675 M81797 M84425 M84426 S62045 AL120339

Unigene Cluster for TACR1:

Tachykinin receptor 1

Hs.633301 [show with all ESTs]

Unigene Representative Sequence: NM_001058

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000305249 ENST00000409848

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TACR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TACR1

¹ / ² / ³

10 probe-sets matching TACR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47806_at²	U95-B	1	1.00	1.00	0.53	1.29	--	--	--	--	--
35077_at²^{, 3}	U95-A	1	0.94	1.00	0.86	0.72	M74290	1.00	1.00	1.00	1
210637_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M81797	0.80	1.00	0.91	1
208049_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015727	0.60	1.00	0.82	1
208048_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015727	0.60	1.00	0.82	1
230908_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
210637_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208049_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208048_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230908_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TACR1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AACTCACAGT

SOURCE GeneReport for Unigene cluster: Hs.633301
Expression variation in blood from EXPOLDB for TACR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TACR1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TACR1¹	--	tachykinin receptor 1	92.96(n) 97.54(a)	403815 NM_001012619.1 NP_001012637.1
chimpanzee (Pan troglodytes)	TACR1¹	--	tachykinin receptor 1	99.51(n) 99.75(a)	470412 XM_525793.2 XP_525793.2
rat (Rattus norvegicus)	Tacr1¹	--	tachykinin receptor 1	89.35(n) 94.59(a)	24807 NM_012667.1 NP_036799.1
mouse (Mus musculus)	Tacr1^{1, 5}	6⁵	tachykinin receptor 1^{1, 5}	89.76(n)¹ 94.59(a)¹	21336¹ NM_009313.4¹ NP_033339.2¹ AK038558⁵ AK048680⁵ (see all 10)
chicken (Gallus gallus)	TACR1¹	--	tachykinin receptor 1	78.21(n) 79.12(a)	395677 NM_204868.1 NP_990199.1

About this table Species with no ortholog for TACR1

ENSEMBL Gene Tree for TACR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TACR1 gene

TACR3² TACR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/815 NCBI SNPs in TACR1 are shown (see all 815 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 294)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1106855^1,2	C,F,H,O	75131495(-)	`AGTACG/ACAGCG`	2	--	ng5¹ int¹		11		EU EA WA NA	978
	rs881^1,2	C,F,H,O	75129937(-)	`TATGGG/CTTAGG`	1	--	ut3¹		9		MN NA EU EA WA	910
	rs12713828^1,2	A,C,F,H	75129589(+)	`GTTATG/ATGGTG`	1	--	ut3¹		4		EU EA WA	416
	rs2111375^1,2	A,C,F,H	75281386(+)	`CCGGTG/ACACCG`	2	--	ng3¹		5		EA EU WA	1696
	rs3732303^1,2	A,C,F,H	75127635(+)	`TTTCTC/TACATG`	1	--	ut3¹		5		EA EU WA	1918
	rs17563917^1,2	C,F,H	75131369(+)	`AACTGC/GTGGAA`	2	--	int¹ ng5¹		11		NA EU EA WA	976
	rs2193405^1,2	A,C	75280476(+)	`ACAGCA/TGGAGT`	2	--	ng3¹		0	--	--	--	--
--	rs1106854^1,2	C,F	75131522(-)	`AGTTTG/ATTCAC`	2	--	int¹ ng5¹		1		EU	112
--	rs7564978^1,2	A,C	75281735(+)	`AGAGAG/TGCTTT`	1	--	ng3¹		0	--	--	--	--
	rs3755455^1,2	C,H	75131815(+)	`TAGGAT/GGGCCG`	2	--	int¹ ut3¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for TACR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 162323

10/62 Novoseek disease relationships for TACR1 gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	62.63	32	7516885 (3), 7512575 (2), 1328053 (2), 1378485 (1) (see all 23)
inflammation	54.39	75	12559111 (3), 11275376 (3), 8240667 (2), 16777450 (2) (see all 52)
hyperalgesia	53.00	19	1381521 (2), 15964684 (2), 9323204 (2), 17123731 (2) (see all 12)
migraine	30.79	8	8846424 (2), 11281817 (1), 15155133 (1), 7536309 (1) (see all 7)
asthma	28.45	12	8240667 (2), 17392578 (2), 15155133 (1), 15334652 (1) (see all 8)
inflammatory bowel diseases	26.51	11	7529913 (2), 17368292 (1), 11073811 (1), 10940277 (1) (see all 7)
causalgia	20.93	1	12855316 (1)
anxiety disorders	16.35	1	16594257 (1)
colitis ulcerative	15.97	9	11073811 (2), 17368292 (1), 7587798 (1), 10940277 (1) (see all 6)
anxiety depression	15.77	2	16983662 (1), 18600583 (1)

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Human Genome Epidemiology Navigator: TACR1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/521 PubMed articles for TACR1 gene (see all 521 ):

Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PubMed id 1657150)^{1, 2, 3, 4} Gerard N.P.... Gerard C. (1991)
Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. (PubMed id 1310144)^{1, 3, 4} Fong T.M.... Strader C.D. (1992)
Molecular cloning, structural characterization and functional expression of the human substance P receptor. (PubMed id 1718267)^{1, 3, 4} Takeda Y.... Krause J.E. (1991)
The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)^{1, 3, 4} Takahashi K.... Nakanishi S. (1992)
Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PubMed id 8384323)^{1, 3, 4} Fong T.M.... Strader C.D. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant. (PubMed id 15452552)^{3, 4} Randolph G.P....Duffy R.A. (2004)
The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal. (PubMed id 11864635)^{3, 4} Page N.M. and Bell N.J. (2002)
Isolation and characterisation of the human lung NK-1 receptor cDNA. (PubMed id 1659396)^{3, 4} Hopkins B.... Graham A. (1991)
Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. (PubMed id 18713853)^{1, 3} Lai J.P....Douglas S.D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6869	HGNC: 11526	AceView: TACR1	Ensembl:ENSG00000115353	euGenes: HUgn6869
ECgene: TACR1	H-InvDB: TACR1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Tachykinin

Licensable Technologies for TACR1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TACR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TACR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TACR1		Antibodies for TACR1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TACR1		Small molecules for TACR1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TACR1 Gene at Home site.
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TACR1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for TACR1

Summaries
for TACR1

Genomic Location
for TACR1

Proteins
for TACR1

Protein Domains/
Families
for TACR1

Gene Function
for TACR1

Pathways & Interactions
for TACR1

Drugs & Compounds
for TACR1

Transcripts
for TACR1

Expression
for TACR1

Orthologs
for TACR1

Paralogs
for TACR1

SNPs/Variants
for TACR1

Disorders & Mutations
for TACR1

Medical News
for TACR1

Publications
for TACR1

Search for TACR1

Genome Databases showing TACR1

Other Databases showing TACR1

Specialized Databases showing TACR1

Licensable Technologies
for TACR1

Services
for TACR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TACR1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor TACR1

Summariesfor TACR1

Genomic Locationfor TACR1

Proteinsfor TACR1

Protein Domains/Familiesfor TACR1

Gene Functionfor TACR1

Pathways & Interactionsfor TACR1

Drugs & Compoundsfor TACR1

Transcriptsfor TACR1

Expression for TACR1

Orthologsfor TACR1

Paralogsfor TACR1

SNPs/Variantsfor TACR1

Disorders & Mutationsfor TACR1

Medical Newsfor TACR1

Publicationsfor TACR1

Search for TACR1

Genome Databases showing TACR1

Other Databases showing TACR1

Specialized Databases showing TACR1

Licensable Technologiesfor TACR1

Servicesfor TACR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TACR1

Summaries
for TACR1

Genomic Location
for TACR1

Proteins
for TACR1

Protein Domains/
Families
for TACR1

Gene Function
for TACR1

Pathways & Interactions
for TACR1

Drugs & Compounds
for TACR1

Transcripts
for TACR1

Expression
for TACR1

Orthologs
for TACR1

Paralogs
for TACR1

SNPs/Variants
for TACR1

Disorders & Mutations
for TACR1

Medical News
for TACR1

Publications
for TACR1

Licensable Technologies
for TACR1

Services
for TACR1