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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TACR1 Gene

protein-coding   GIFtS: 68
GCID: GC02M075187

Tachykinin Receptor 1


(Previous symbol: TAC1R)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tachykinin Receptor 11 2 3     NK-1 Receptor2 3
TAC1R1 2 3 5     NKIR2
NK1R2 3 5     Substance-P Receptor2
NK-1R2 3     Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor)2
SPR2 3     

External Ids:    HGNC: 115261   Entrez Gene: 68692   Ensembl: ENSG000001153537   OMIM: 1623235   UniProtKB: P251033   

Export aliases for TACR1 gene to outside databases

Previous GC identifers: GC02M075413 GC02M075233 GC02M075250 GC02M075129 GC02M075010


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TACR1 Gene:
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by
interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor
for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the
mediation of phosphatidylinositol metabolism of substance P. (provided by RefSeq, Sep 2008)

GeneCards Summary for TACR1 Gene: 
TACR1 (tachykinin receptor 1) is a protein-coding gene. Diseases associated with TACR1 include telogen effluvium, and causalgia, and among its related super-pathways are GPCR ligand binding and Peptide GPCRs. GO annotations related to this gene include tachykinin receptor activity and substance P receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103
Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G
proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
receptor to tachykinins is: substance P > substance K > neuromedin-K

summary for TACR1 Gene:
The neurokinin (NK) 1 receptor is a member of the tachykinin family of G-protein-coupled receptors which
also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS
(particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues. NK1
receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission,
immune modulation and airway and lung function. The receptor displays greater potency for the endogenous
agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1
receptor has been localized on chromosome 2 (2p13.1-p12).

Gene Wiki entry for TACR1 (Tachykinin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TACR1 gene promoter:
         GR   AP-1   GR-beta   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTACR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TACR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TACR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p13.1-p12

TACR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M075187:  view genomic region     (about GC identifiers)

Start:
75,273,590 bp from pter      End:
75,426,826 bp from pter
Size:
153,237 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103 (See protein sequence)
Recommended Name: Substance-P receptor  
Size: 407 amino acids; 46251 Da
Subunit: Interacts with ARRB1 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for TACR1:
2KS9 (3D)        2KSA (3D)        2KSB (3D)    
Secondary accessions: A8K150

Explore the universe of human proteins at neXtProt for TACR1: NX_P25103

Explore proteomics data for TACR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25103

  • TACR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TACR1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001049.1  NP_056542.1  

    ENSEMBL proteins: 
     ENSP00000303522   ENSP00000386448  
    Reactome Protein details: P25103
    Human Recombinant Protein Products for TACR1: 
    EMD Millipore Purified and/or Recombinant TACR1 Protein
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    Novus Biologicals TACR1 Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TACR1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1657150
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane ----

    TACR1 for ontologies           About GeneDecksing



    TACR1 Antibody Products: 
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    Assay Products for TACR1: 
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    Cloud-Clone Corp. CLIAs for TACR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TACR: GPCR / Class A : Tachykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NK1 receptor 
    Tachykinin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001681 Neurokn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000046 NK1_rcpt

    Graphical View of Domain Structure for InterPro Entry P25103

    ProtoNet protein and cluster: P25103

    2 Blocks protein domains:
    IPB000046 Neurokinin NK1 receptor signature
    IPB001681 Neurokinin receptor signature


    UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103
    Similarity: Belongs to the G-protein coupled receptor 1 family


    TACR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NK1R_HUMAN, P25103
    Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G
    proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
    receptor to tachykinins is: substance P > substance K > neuromedin-K

         Genatlas biochemistry entry for TACR1:
    tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in
    mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004995tachykinin receptor activity TAS8985172
    GO:0005515protein binding IPI17986524
    GO:0016496substance P receptor activity IEA--
         
    TACR1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TACR1:
     Decreased Salmonella enterica   Decreased nuclei size in G2M  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tacr1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     nervous system  respiratory system  skeleton 

    TACR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tacr1tm1Rhn for TACR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TACR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TACR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TACR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TACR1 

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TACR1 (see all 16):
    hsa-miR-374b* hsa-miR-3673 hsa-miR-206 hsa-miR-4307 hsa-miR-642a hsa-miR-4268 hsa-miR-222 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidTACR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TACR1 (NM_001058)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACR1
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                         Customized lentivirus expression plasmids for stable overexpression of TACR1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TACR1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TACR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TACR1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    NK1R-mediated Non-Apoptotic PCD

    3 BioSystems Pathways for TACR1
        SIDS Susceptibility Pathways
    Spinal Cord Injury
    Peptide GPCRs

    5/9        Reactome Pathways for TACR1 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    3         Kegg Pathways  (Kegg details for TACR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Measles


    TACR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TACR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for TACR1 (P251033 ENSP000003035224) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    TAC4Q86UU93, ENSP000003340424I2D: score=1 STRING: ENSP00000334042
    TAC1P203663, ENSP000003211064I2D: score=2 STRING: ENSP00000321106
    GRK5P349473, ENSP000003766094I2D: score=2 STRING: ENSP00000376609
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002118aggressive behavior IEA--
    GO:0002526acute inflammatory response IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0003051angiotensin-mediated drinking behavior IEA--
    GO:0006950response to stress ----

    TACR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TACR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TACR1

    Compounds for TACR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RP 67580Potent and selective NK1 antagonist[135911-02-3]
    GR 73632 Potent, selective NK1 agonist [133156-06-6]
    L-733,060 hydrochloride Potent NK1 antagonist[148700-85-0]
    CP 99994 dihydrochlorideHigh affinity NK1 antagonist[136982-36-0]
    L-732,138 Potent, selective NK1 antagonist [148451-96-1]

    2 HMDB Compounds for TACR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Substance PArg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 33507-63-0--

    3 DrugBank Compounds for TACR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AprepitantMK-0517 (see all 2)170729-80-3targetantagonist12227806 12784346 15121485 12590540 11752352 17643344
    VapreotideBMY 41606 (see all 6)103222-11-3targetantagonist11752352 7556407
    Ketamine(-)-Ketamine (see all 7)6740-88-1targetantagonist12818951

    10/43 IUPHAR Ligands for TACR1 (NK1 receptor) (see all 43)    About this table 
    LigandTypeActionAffinityPubmed IDs
    hemokinin 1
    AgonistFull agonist9.8 - 11.711786503
    aprepitant
    AntagonistAntagonist10.79804700
    vofopitant
    AntagonistAntagonist10.68876035
    substance P
    AgonistFull agonist8.5 - 10.311786503 15265501
    T2328
    AntagonistAntagonist10.118187929
    LY303870
    AntagonistAntagonist9.8 - 107473161
    ZD6021
    AntagonistAntagonist9.911408556
    [Sar9,Met(O2)11]SP
    AgonistFull agonist9.7 - 9.98702757
    ezlopitant
    AntagonistAntagonist9.712372904
    CP 99994
    AntagonistAntagonist9.3 - 9.712206858 9190866

    10/112 Novoseek inferred chemical compound relationships for TACR1 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aprepitant 93.2 62 19148578 (4), 15485308 (2), 18208572 (2), 15813642 (2) (see all 45)
    septide 90.9 55 10051129 (4), 8985159 (3), 7518302 (3), 7685292 (2) (see all 25)
    fk 888 88.4 17 7531648 (4), 7504102 (2), 7516885 (2), 9399104 (1) (see all 9)
    cp 96345 88.2 6 7687919 (1), 7538136 (1), 18160487 (1), 7823080 (1) (see all 6)
    senktide 87.2 12 9402049 (1), 15145080 (1), 7538871 (1), 8583573 (1) (see all 11)
    fk 224 84.1 5 7504102 (1), 8529964 (1), 8821532 (1), 7682142 (1) (see all 5)
    palonosetron 82.7 6 17366928 (1), 16499138 (1), 20307224 (1), 16608997 (1) (see all 5)
    gr 71251 81.8 6 7688874 (1), 7689402 (1), 11480541 (1), 16077032 (1)
    ly303870 81.5 5 7473161 (5)
    gr 82334 80.9 5 7538871 (1), 7679029 (1), 7823080 (1), 7679026 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TACR1 / NK1R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TACR1 gene (2 alternative transcripts): 
    NM_001058.3  NM_015727.2  

    Unigene Cluster for TACR1:

    Tachykinin receptor 1
    Hs.633301  [show with all ESTs]
    Unigene Representative Sequence: NM_001058
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305249(uc002sng.2 uc002snh.3) ENST00000409848 ENST00000497764

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACR1
    Sirion Biotech Customized lentivirus for stable overexpression of TACR1 
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACR1

    Additional mRNA sequence: 

    AK289765.1 AY462098.1 BC074911.2 BC074912.2 BC095528.1 M74290.1 M76675.1 M81797.1 
    M84425.1 M84426.1 S62045.1 

    5 DOTS entries:

    DT.309603  DT.70105091  DT.100742331  DT.432141  DT.95093567 

    13 AceView cDNA sequences:

    AY462098 NM_015727 M81797 BC074912 S62045 M84425 M74290 BC074911 
    M84426 AL120339 CD246198 M76675 NM_001058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TACR1 expression in normal human tissues (normalized intensities)      TACR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCACAGT
    TACR1 Expression
    About this image


    TACR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Midbrain tegmentum
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)
             sensory organ/eye/cornea   
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones

    See TACR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TACR1

    SOURCE GeneReport for Unigene cluster: Hs.633301
        SABiosciences Expression via Pathway-Focused PCR Arrays including TACR1 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TACR1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacr11 , 5 tachykinin receptor 11, 5 89.76(n)1
    94.59(a)1
      6 (35.94 cM)5
    213361  NM_009313.51  NP_033339.21 
     824024755 
    chicken
    (Gallus gallus)
    Aves TACR11 tachykinin receptor 1 78.21(n)
    79.12(a)
      395677  NM_204868.1  NP_990199.1 
    lizard
    (Anolis carolinensis)
    Reptilia TACR16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343662.1(186190-214023)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.201262 Xenopus laevis transcribed sequence with moderate similarity more 75.37(n)    BX851484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nk1a1 substance-P receptor-like 72.49(n)
    73.54(a)
      100003539  XM_001343037.3  XP_001343073.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Takr99D3 G-protein coupled receptor protein
    signaling pathway more
    45(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea tkr-13 G protein coupled receptor 36(a)
    (best of 4)
      III(9457359-9458961)   --


    ENSEMBL Gene Tree for TACR1 (if available)
    TreeFam Gene Tree for TACR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TACR1 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    14 SIMAP similar genes for TACR1 using alignment to 4 protein entries:     NK1R_HUMAN (see all proteins):
    TACR3    TACR2    hA2aR    GIR    GPR83    AGTR1
    HTR5A    PRLHR    GPR1    HCRTR1    NPY2R    OPRM1
    QRFPR    GPR50

    TACR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3182 SNPs in TACR1 are shown (see all 3182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0268264
    ----see VAR_0268262 Y H mis40--------
    rs1451247501,2
    C--75029605(+) GGTTG-/GGG   
       GTTGT
    GGGAG
    2 -- int10--------
    rs38361911,2
    C--75029608(+) TGGGG-/GTT   
       GTGGG
    AGACG
    2 -- int10--------
    rs1895421491,2
    --75061943(+) TTTTTC/TCCTAC 2 -- int10--------
    rs349603391,2
    C--75103359(+) AAATA-/ACT   
      A
    /CTAC
    CTGAG
    2 -- int10--------
    rs1459402881,2
    C--75124814(+) AATAG-/AAAAAAA 2 -- int10--------
    rs728242181,2
    C,F--75144375(+) ACCCCT/CTTTTT 1 -- int12Minor allele frequency- C:0.18NA EA 240
    rs127138271,2
    C,F,H--75144407(+) GTGGTC/TTGAAG 1 -- int120Minor allele frequency- T:0.29NS EA NA WA CSA 1210
    rs1464013751,2
    --75144487(+) TCCTAC/TGAAAA 1 -- int10--------
    rs1891404821,2
    --75144557(+) ATCACA/TGTCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TACR1 (75273590 - 75426826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for TACR1 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664298CNV Deletion23128226
    esv2720214CNV Deletion23290073
    esv272151CNV Insertion20981092
    esv2489063CNV Insertion19546169
    esv1335930CNV Insertion17803354
    esv274003CNV Insertion20981092
    nsv525695CNV Loss19592680
    esv28202CNV Loss19812545
    dgv32n64CNV Loss17921354
    nsv438354CNV Loss16468122

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162323    OMIM disorders: --

    20/88 diseases for TACR1 (see all 88):    About MalaCards
    telogen effluvium    causalgia    meningoencephalitis    social phobia
    fibromyalgia    cystitis    motion sickness    trypanosomiasis
    pain agnosia    complex regional pain syndrome    chronic pain    multiple system atrophy
    measles    bronchitis    anxiety disorder    paine syndrome
    allergic contact dermatitis    contact dermatitis    dermatitis    status epilepticus

    6 diseases from the University of Copenhagen DISEASES database for TACR1:
    Migraine     Pain agnosia     Asthma     Cystitis
    Pancreatitis     Complex regional pain syndrome

    TACR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/65 Novoseek inferred disease relationships for TACR1 gene (see all 65)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 61.4 32 7516885 (3), 7512575 (2), 1328053 (2), 1378485 (1) (see all 23)
    inflammation 55.7 78 12559111 (3), 11275376 (3), 8240667 (2), 16777450 (2) (see all 55)
    hyperalgesia 53.2 19 1381521 (2), 15964684 (2), 9323204 (2), 17123731 (2) (see all 12)
    migraine 30.4 8 8846424 (2), 11281817 (1), 15155133 (1), 7536309 (1) (see all 7)
    asthma 29 13 8240667 (2), 17392578 (2), 15155133 (1), 15334652 (1) (see all 9)
    airways disease 28.2 1 7682142 (1)
    inflammatory bowel diseases 25.9 11 7529913 (2), 17368292 (1), 11073811 (1), 10940277 (1) (see all 7)
    bronchitis chronic 22.6 1 7682142 (1)
    causalgia 19.2 1 12855316 (1)
    anxiety depression 17.2 3 20074437 (1), 16983662 (1), 18600583 (1)

    Genetic Association Database (GAD): TACR1
    Human Genome Epidemiology (HuGE) Navigator: TACR1 (19 documents)

    Export disorders for TACR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TACR1 gene, integrated from 9 sources (see all 711):
    (articles sorted by number of sources associating them with TACR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PubMed id 1657150)1, 2, 3, 9 Gerard N.P.... Gerard C. (1991)
    2. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PubMed id 18452185)1, 4, 9 Hodges L.M....Hamilton S.P. (2008)
    3. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. (PubMed id 1310144)1, 2, 9 Fong T.M.... Strader C.D. (1992)
    4. Molecular cloning, structural characterization and functional expression of the human substance P receptor. (PubMed id 1718267)1, 2, 9 Takeda Y.... Krause J.E. (1991)
    5. The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)1, 2, 9 Takahashi K.... Nakanishi S. (1992)
    6. Candidate-gene approach in fibromyalgia syndrome: ass ociation analysis of the genes encoding substance P receptor, dopamine transpor ter and alpha1-antitrypsin. (PubMed id 20074437)1, 4, 9 Ablin J.N....Orr-Urtreger A. (2009)
    7. Tachykinin receptor 1 variants associated with aggression in suicidal behavior. (PubMed id 17443717)1, 4, 9 Giegling I....Serretti A. (2007)
    8. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PubMed id 16893949)1, 4, 9 Park H.K....Kim Y.Y. (2006)
    9. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PubMed id 8384323)1, 2, 9 Fong T.M.... Strader C.D. (1993)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6869 HGNC: 11526 AceView: TACR1 Ensembl:ENSG00000115353 euGenes: HUgn6869
    ECgene: TACR1 Kegg: 6869 H-InvDB: TACR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TACR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Tachykinin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TACR1 gene:
    Search GeneIP for patents involving TACR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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