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Aliases for TACR1 Gene

Aliases for TACR1 Gene

  • Tachykinin Receptor 1 2 3 4 5
  • NK-1 Receptor 3 4
  • TAC1R 3 4
  • NK-1R 3 4
  • NK1R 3 4
  • SPR 3 4
  • Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) 3
  • Substance-P Receptor 3
  • NKIR 3

External Ids for TACR1 Gene

Previous HGNC Symbols for TACR1 Gene

  • TAC1R

Previous GeneCards Identifiers for TACR1 Gene

  • GC02M075413
  • GC02M075233
  • GC02M075250
  • GC02M075187
  • GC02M075129

Summaries for TACR1 Gene

Entrez Gene Summary for TACR1 Gene

  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include Neurotrophic Keratopathy and Spinocerebellar Ataxia 23. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and substance P receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot for TACR1 Gene

  • This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Tocris Summary for TACR1 Gene

  • The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.

Gene Wiki entry for TACR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR1 Gene

Genomics for TACR1 Gene

Regulatory Elements for TACR1 Gene

Enhancers for TACR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G075604 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -407.3 -407331 5.5 WRNIP1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 FOS ZNF548 ZHX2 EVA1A ENSG00000221638 MRPL19 TACR1 GCFC2 GC02M075596
GH02G075154 1.1 Ensembl ENCODE 11.6 +45.5 45453 1.2 FOXA2 ZSCAN4 DMAP1 ZSCAN9 CREM KLF11 NR2F2 ZNF217 SSRP1 KLF16 TACR1 ENSG00000270571 LOC105374812
GH02G075153 1 ENCODE 11.6 +46.2 46231 0.2 PKNOX1 FOXA2 MLX ARID4B DMAP1 FOS SP5 ZHX2 MXD4 MIER2 TACR1 ENSG00000270571 LOC105374812 LOC105374811
GH02G075613 0.9 ENCODE dbSUPER 10.3 -414.5 -414539 1.5 GTF2F1 CTCF CEBPB RAD21 YY1 HNF4A FOXP2 MAFK EVA1A TACR1 GCFC2 MRPL19 GC02M075596 ENSG00000221638
GH02G074919 0.9 Ensembl 9.7 +279.7 279688 0.8 FOXA2 RB1 NFIB AGO1 SIN3A ZNF48 RAD21 GLIS2 ZNF143 ZNF654 LINC01291 ENSG00000221638 TACR1 ENSG00000236209 GC02P074916
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TACR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACR1 Gene

Chromosome:
2
Start:
75,046,463 bp from pter
End:
75,199,700 bp from pter
Size:
153,238 bases
Orientation:
Minus strand

Genomic View for TACR1 Gene

Genes around TACR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR1 Gene

Proteins for TACR1 Gene

  • Protein details for TACR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25103-NK1R_HUMAN
    Recommended name:
    Substance-P receptor
    Protein Accession:
    P25103
    Secondary Accessions:
    • A8K150

    Protein attributes for TACR1 Gene

    Size:
    407 amino acids
    Molecular mass:
    46251 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for TACR1 Gene

    Alternative splice isoforms for TACR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TACR1 Gene

Post-translational modifications for TACR1 Gene

  • Glycosylation at Asn14 and posLast=1818
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR1 Gene

Domains & Families for TACR1 Gene

Gene Families for TACR1 Gene

Suggested Antigen Peptide Sequences for TACR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25103

UniProtKB/Swiss-Prot:

NK1R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR1: view

Function for TACR1 Gene

Molecular function for TACR1 Gene

GENATLAS Biochemistry:
tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Gene Ontology (GO) - Molecular Function for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004995 tachykinin receptor activity TAS 8985172
GO:0005515 protein binding IPI 17986524
GO:0016496 substance P receptor activity IBA --
genes like me logo Genes that share ontologies with TACR1: view
genes like me logo Genes that share phenotypes with TACR1: view

Animal Models for TACR1 Gene

MGI Knock Outs for TACR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TACR1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACR1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACR1 Gene

Localization for TACR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endosome 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 1657150
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TACR1: view

Pathways & Interactions for TACR1 Gene

genes like me logo Genes that share pathways with TACR1: view

Gene Ontology (GO) - Biological Process for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002118 aggressive behavior IEA --
GO:0002526 acute inflammatory response IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0003051 angiotensin-mediated drinking behavior IEA --
GO:0006954 inflammatory response TAS 10854844
genes like me logo Genes that share ontologies with TACR1: view

No data available for SIGNOR curated interactions for TACR1 Gene

Drugs & Compounds for TACR1 Gene

(134) Drugs for TACR1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprepitant Approved, Investigational Pharma Antagonist, antagonist, Target Substance P (SP) inhibitor 163
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 163
Vapreotide Approved, Investigational Pharma Full agonist, Agonist, Target, antagonist 2
netupitant Approved Pharma Antagonist, Target, antagonist 0
Rolapitant Approved Pharma Antagonist Orally active neurokinin NK1 receptor antagonist. 0

(41) Additional Compounds for TACR1 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY303870
Antagonist
[<sup>3</sup>H]BH-[Sar<sup>9</sup>,Met(O<sub>2</sub>)<sup>11</sup>]SP
[Pro<sup>9</sup>]SP
Full agonist, Agonist
neuropeptide-alpha
Full agonist, Agonist
SR 140,333
Antagonist

(5) Tocris Compounds for TACR1 Gene

Compound Action Cas Number
CP 99994 dihydrochloride High affinity NK1 antagonist 145148-39-6
GR 73632 Potent, selective NK1 agonist 133156-06-6
L-732,138 Potent, selective NK1 antagonist 148451-96-1
RP 67580 Potent and selective NK1 antagonist 135911-02-3
SR 140333 Potent NK1 receptor antagonist 153050-21-6

(23) ApexBio Compounds for TACR1 Gene

Compound Action Cas Number
[Sar9,Met(O2)11]-Substance P 110880-55-2
Aprepitant Substance P (SP) inhibitor 170729-80-3
C14TKL-1
CP 96345 132746-60-2
CP 99994 dihydrochloride 145148-39-6
FK 888 138449-07-7
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
GR 73632 133156-06-6
GR 82334 129623-01-4
Hemokinin 1 (human) 491851-53-7
Hemokinin 1 (mouse) 208041-90-1
L 760735 188923-01-5
L-732,138 148451-96-1
L-733,060 hydrochloride 148687-76-7
Maropitant NK1 receptor antagonist 147116-67-4
ML314 1448895-09-7
NKP608 Non-peptidic derivative of 4-aminopiperidine 177707-12-9
Rolapitant Orally active neurokinin NK1 receptor antagonist. 552292-08-7
RP 67580 135911-02-3
SDZ NKT 343 180046-99-5
Spantide I 91224-37-2
SR 140333 153050-21-6
genes like me logo Genes that share compounds with TACR1: view

Drug Products

Transcripts for TACR1 Gene

mRNA/cDNA for TACR1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR1 Gene

Tachykinin receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACR1 Gene

No ASD Table

Relevant External Links for TACR1 Gene

GeneLoc Exon Structure for
TACR1
ECgene alternative splicing isoforms for
TACR1

Expression for TACR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TACR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.5) and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for TACR1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TACR1 Gene



Protein tissue co-expression partners for TACR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TACR1 Gene:

TACR1

SOURCE GeneReport for Unigene cluster for TACR1 Gene:

Hs.633301

Evidence on tissue expression from TISSUES for TACR1 Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Intestine(2.3)
  • Blood(2.1)
  • Muscle(2.1)
  • Kidney(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with TACR1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TACR1 Gene

Orthologs for TACR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACR1 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia NK1R 35
  • 94 (a)
OneToOne
TACR1 34
  • 89.76 (n)
dog
(Canis familiaris)
Mammalia TACR1 34 35
  • 92.96 (n)
mouse
(Mus musculus)
Mammalia Tacr1 34 16 35
  • 89.76 (n)
rat
(Rattus norvegicus)
Mammalia Tacr1 34
  • 89.35 (n)
oppossum
(Monodelphis domestica)
Mammalia TACR1 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ASPR 35
  • 79 (a)
OneToOne
TACR1 34
  • 78.21 (n)
lizard
(Anolis carolinensis)
Reptilia TACR1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr1 34
  • 71.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20126 34
zebrafish
(Danio rerio)
Actinopterygii tacr1a 34 35
  • 70.82 (n)
tacr1b 35
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Takr99D 36 35
  • 45 (a)
Takr86C 36 35
  • 37 (a)
CG10626 36
  • 32 (a)
NepYr 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea C49A9.7 36
  • 36 (a)
tkr-1 36 35
  • 36 (a)
tkr-2 35
  • 30 (a)
ManyToMany
Y59H11AL.1 36
  • 29 (a)
C50F7.1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for TACR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR1 Gene

ENSEMBL:
Gene Tree for TACR1 (if available)
TreeFam:
Gene Tree for TACR1 (if available)

Paralogs for TACR1 Gene

(15) SIMAP similar genes for TACR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TACR1: view

Variants for TACR1 Gene

Sequence variations from dbSNP and Humsavar for TACR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000002603 -- 75,095,303(+) TGGCT(A/G)TAACC intron-variant
rs1000010907 -- 75,175,734(+) AATAT(C/T)CTTAG intron-variant
rs1000030359 -- 75,055,427(+) TCAGG(A/G)CTCTC intron-variant
rs1000040533 -- 75,073,924(+) ACTCA(A/G)GGGCT intron-variant
rs1000061392 -- 75,055,681(+) CAAGA(C/T)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACR1 Gene

Variant ID Type Subtype PubMed ID
dgv32n64 CNV loss 17921354
esv1335930 CNV insertion 17803354
esv2489063 CNV insertion 19546169
esv2664298 CNV deletion 23128226
esv2759062 CNV loss 17122850
esv28202 CNV loss 19812545
esv3583870 CNV loss 25503493
esv3591293 CNV loss 21293372
nsv1001495 CNV gain 25217958
nsv10035 CNV gain 18304495
nsv1142958 CNV tandem duplication 24896259
nsv438354 CNV loss 16468122
nsv520917 CNV gain 19592680
nsv525695 CNV loss 19592680
nsv527009 CNV gain 19592680
nsv582218 CNV loss 21841781
nsv834262 CNV gain 17160897
nsv963624 CNV duplication 23825009
nsv998145 CNV loss 25217958

Variation tolerance for TACR1 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACR1 Gene

Disorders for TACR1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TACR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
spinocerebellar ataxia 23
  • spinocerebellar ataxia type 23
cystitis
  • infective cystitis
astrocytoma
  • astrocytic tumor
mood disorder
  • episodic mood disorder
- elite association - COSMIC cancer census association via MalaCards
Search TACR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACR1

Genetic Association Database (GAD)
TACR1
Human Genome Epidemiology (HuGE) Navigator
TACR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACR1
genes like me logo Genes that share disorders with TACR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR1 Gene

Publications for TACR1 Gene

  1. Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. (PMID: 20074437) Ablin J.N. … Orr-Urtreger A. (Clin. Exp. Rheumatol. 2009) 3 22 46 64
  2. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PMID: 18452185) Hodges L.M. … Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  3. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PMID: 16893949) Park H.K. … Kim Y.Y. (Thorax 2006) 3 22 46 64
  4. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PMID: 8384323) Fong T.M. … Strader C.D. (Nature 1993) 3 4 22 64
  5. The primary structure and gene organization of human substance P and neuromedin K receptors. (PMID: 1312928) Takahashi K. … Nakanishi S. (Eur. J. Biochem. 1992) 3 4 22 64

Products for TACR1 Gene

Sources for TACR1 Gene

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