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TACR1 Gene

protein-coding   GIFtS: 68
GCID: GC02M075187

Tachykinin Receptor 1


(Previous symbol: TAC1R)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tachykinin Receptor 11 2 3     NK-1 Receptor2 3
TAC1R1 2 3 5     NKIR2
NK1R2 3 5     Substance-P Receptor2
NK-1R2 3     Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor)2
SPR2 3     

External Ids:    HGNC: 115261   Entrez Gene: 68692   Ensembl: ENSG000001153537   OMIM: 1623235   UniProtKB: P251033   

Export aliases for TACR1 gene to outside databases

Previous GC identifers: GC02M075413 GC02M075233 GC02M075250 GC02M075129 GC02M075010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TACR1 Gene:
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by
interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor
for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the
mediation of phosphatidylinositol metabolism of substance P. (provided by RefSeq, Sep 2008)

GeneCards Summary for TACR1 Gene:
TACR1 (tachykinin receptor 1) is a protein-coding gene. Diseases associated with TACR1 include telogen effluvium, and causalgia. GO annotations related to this gene include tachykinin receptor activity and substance P receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103
Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G
proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
receptor to tachykinins is: substance P > substance K > neuromedin-K

summary for TACR1 Gene:
The neurokinin (NK) 1 receptor is a member of the tachykinin family of G-protein-coupled receptors which
also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS
(particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues. NK1
receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission,
immune modulation and airway and lung function. The receptor displays greater potency for the endogenous
agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1
receptor has been localized on chromosome 2 (2p13.1-p12).

Gene Wiki entry for TACR1 (Tachykinin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TACR1 gene promoter:
         GR   AP-1   GR-beta   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTACR1 promoter sequence
   Search Chromatin IP Primers for TACR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TACR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p13.1-p12

TACR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M075187:  view genomic region     (about GC identifiers)

Start:
75,273,590 bp from pter      End:
75,426,826 bp from pter
Size:
153,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103 (See protein sequence)
Recommended Name: Substance-P receptor  
Size: 407 amino acids; 46251 Da
Subunit: Interacts with ARRB1 (By similarity)
3 PDB 3D structures from and Proteopedia for TACR1:
2KS9 (3D)        2KSA (3D)        2KSB (3D)    
Secondary accessions: A8K150
Alternative splicing: 2 isoforms:  P25103-1   P25103-3   (In contrast to Fong et al. data (PubMed:1310144), isoform 2 is not detected by PCR in any of 24 human tissues examined including the placenta (PubMed:11864635))

Explore the universe of human proteins at neXtProt for TACR1: NX_P25103

Explore proteomics data for TACR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn14, Asn18

  • See TACR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001049.1  NP_056542.1  

    ENSEMBL proteins: 
     ENSP00000303522   ENSP00000386448  
    Reactome Protein details: P25103

    TACR1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TACR1 Protein
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    OriGene Protein Over-expression Lysate for TACR1
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    Novus Biologicals TACR1 Proteins
    Novus Biologicals TACR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TACR1

    TACR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TACR1
    R&D Systems Antibodies for TACR1 (NK1R)
    OriGene Antibodies for TACR1
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    Novus Biologicals TACR1 Antibodies
    Abcam antibodies for TACR1
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    LSBio Antibodies in human, mouse, rat for TACR1

    TACR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript TACR1-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for TACR1
    Cloud-Clone Corp. CLIAs for TACR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TACR: GPCR / Class A : Tachykinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NK1 receptor
    Tachykinin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001681 Neurokn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR000046 NK1_rcpt

    Graphical View of Domain Structure for InterPro Entry P25103

    ProtoNet protein and cluster: P25103

    2 Blocks protein domains:
    IPB000046 Neurokinin NK1 receptor signature
    IPB001681 Neurokinin receptor signature


    UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103
    Similarity: Belongs to the G-protein coupled receptor 1 family


    TACR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NK1R_HUMAN, P25103
    Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G
    proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this
    receptor to tachykinins is: substance P > substance K > neuromedin-K

         Genatlas biochemistry entry for TACR1:
    tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in
    mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004995tachykinin receptor activity TAS8985172
    GO:0005515protein binding IPI17986524
    GO:0016496substance P receptor activity IEA--
         
    TACR1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TACR1:
     Decreased Salmonella enterica   Decreased nuclei size in G2M  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tacr1):
     behavior/neurological  cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system 
     integument  nervous system  respiratory system  skeleton 

    TACR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tacr1tm1Rhn for TACR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TACR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TACR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TACR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TACR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TACR1:
    hsa-let-7b-5p (MIRT032464)

    Block miRNA regulation of human, mouse, rat TACR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TACR1 (see all 16):
    hsa-miR-374b* hsa-miR-3673 hsa-miR-206 hsa-miR-4307 hsa-miR-642a hsa-miR-4268 hsa-miR-222 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidTACR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TACR1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TACR1 (see all 12)
    OriGene ORF clones in mouse, rat for TACR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TACR1 (NM_001058)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACR1

    Cell Line
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    GenScript TACR1-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for TACR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NK1R_HUMAN, P25103: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1657150
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane ----

    TACR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TACR1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    Tachykinin receptors bind tachykinins0.00
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TACR1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    NK1R-mediated Non-Apoptotic PCD

    3 BioSystems Pathways for TACR1
        SIDS Susceptibility Pathways
    Spinal Cord Injury
    Peptide GPCRs

    2 Reactome Pathways for TACR1
        Tachykinin receptors bind tachykinins
    G alpha (q) signalling events


    3 Kegg Pathways  (Kegg details for TACR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Measles


    TACR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TACR1 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TACR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TACR1 (P251031, 3 ENSP000003035224) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAC1P203661, 3, ENSP000003211064EBI-6655287,EBI-6655360 I2D: score=2 STRING: ENSP00000321106
    GPRASP1Q5JY773, ENSP000003551464I2D: score=1 STRING: ENSP00000355146
    TAC4Q86UU93, ENSP000003340424I2D: score=1 STRING: ENSP00000334042
    GRK5P349473, ENSP000003766094I2D: score=2 STRING: ENSP00000376609
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002118aggressive behavior IEA--
    GO:0002526acute inflammatory response IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0003051angiotensin-mediated drinking behavior IEA--
    GO:0006954inflammatory response TAS10854844

    TACR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TACR1
      Browse compounds at ApexBio 

    Compounds for TACR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RP 67580Potent and selective NK1 antagonist[135911-02-3]
    GR 73632 Potent, selective NK1 agonist [133156-06-6]
    L-733,060 hydrochloride Potent NK1 antagonist[148700-85-0]
    CP 99994 dihydrochlorideHigh affinity NK1 antagonist[136982-36-0]
    L-732,138 Potent, selective NK1 antagonist [148451-96-1]

    2 HMDB Compounds for TACR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Substance PArg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 33507-63-0--

    3 DrugBank Compounds for TACR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AprepitantMK-0517 (see all 2)170729-80-3targetantagonist12227806 12784346 15121485 12590540 11752352 17643344
    VapreotideBMY 41606 (see all 6)103222-11-3targetantagonist11752352 7556407
    Ketamine(-)-Ketamine (see all 7)6740-88-1targetantagonist12818951

    Selected IUPHAR Ligands for TACR1 (NK1 receptor) (see all 43)    About this table
    LigandTypeActionAffinityPubmed IDs
    hemokinin 1
    AgonistFull agonist9.8 - 11.711786503
    aprepitant
    AntagonistAntagonist10.79804700
    vofopitant
    AntagonistAntagonist10.68876035
    substance P
    AgonistFull agonist8.5 - 10.311786503 15265501
    T2328
    AntagonistAntagonist10.118187929
    LY303870
    AntagonistAntagonist9.8 - 107473161
    ZD6021
    AntagonistAntagonist9.911408556
    [Sar9,Met(O2)11]SP
    AgonistFull agonist9.7 - 9.98702757
    ezlopitant
    AntagonistAntagonist9.712372904
    CP 99994
    AntagonistAntagonist9.3 - 9.712206858 9190866

    Selected Novoseek inferred chemical compound relationships for TACR1 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aprepitant 93.2 62 19148578 (4), 15485308 (2), 18208572 (2), 15813642 (2) (see all 45)
    septide 90.9 55 10051129 (4), 8985159 (3), 7518302 (3), 7685292 (2) (see all 25)
    fk 888 88.4 17 7531648 (4), 7504102 (2), 7516885 (2), 9399104 (1) (see all 9)
    cp 96345 88.2 6 7687919 (1), 7538136 (1), 18160487 (1), 7823080 (1) (see all 6)
    senktide 87.2 12 9402049 (1), 15145080 (1), 7538871 (1), 8583573 (1) (see all 11)
    fk 224 84.1 5 7504102 (1), 8529964 (1), 8821532 (1), 7682142 (1) (see all 5)
    palonosetron 82.7 6 17366928 (1), 16499138 (1), 20307224 (1), 16608997 (1) (see all 5)
    gr 71251 81.8 6 7688874 (1), 7689402 (1), 11480541 (1), 16077032 (1)
    ly303870 81.5 5 7473161 (5)
    gr 82334 80.9 5 7538871 (1), 7679029 (1), 7823080 (1), 7679026 (1) (see all 5)



    TACR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TACR1 gene (2 alternative transcripts): 
    NM_001058.3  NM_015727.2  

    Unigene Cluster for TACR1:

    Tachykinin receptor 1
    Hs.633301  [show with all ESTs]
    Unigene Representative Sequence: NM_001058
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305249(uc002sng.2 uc002snh.3) ENST00000409848 ENST00000497764

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat TACR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TACR1 (see all 16):
    hsa-miR-374b* hsa-miR-3673 hsa-miR-206 hsa-miR-4307 hsa-miR-642a hsa-miR-4268 hsa-miR-222 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidTACR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TACR1
    Clone
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    OriGene ORF clones in mouse, rat for TACR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TACR1 (NM_001058)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACR1
    Primer
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    OriGene qPCR primer pairs and template standards for TACR1
    OriGene qSTAR qPCR primer pairs in human, mouse for TACR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TACR1
      QuantiTect SYBR Green Assays in human, mouse, rat TACR1
      QuantiFast Probe-based Assays in human, mouse, rat TACR1

    Additional mRNA sequence: 

    AK289765.1 AY462098.1 BC074911.2 BC074912.2 BC095528.1 M74290.1 M76675.1 M81797.1 
    M84425.1 M84426.1 S62045.1 

    5 DOTS entries:

    DT.309603  DT.70105091  DT.100742331  DT.432141  DT.95093567 

    13 AceView cDNA sequences:

    AY462098 M74290 NM_001058 NM_015727 BC074911 M84425 M81797 M76675 
    CD246198 AL120339 BC074912 M84426 S62045 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TACR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCACAGT
    TACR1 Expression
    About this image


    TACR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Lung (Respiratory System)
             Trachea
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
    TACR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TACR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633301
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TACR1 (see all 6): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TACR1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacr11 , 5 tachykinin receptor 11, 5 89.76(n)1
    94.59(a)1
      6 (35.94 cM)5
    213361  NM_009313.51  NP_033339.21 
     824024755 
    chicken
    (Gallus gallus)
    Aves TACR11 tachykinin receptor 1 78.21(n)
    79.12(a)
      395677  NM_204868.1  NP_990199.1 
    lizard
    (Anolis carolinensis)
    Reptilia TACR16
    tachykinin receptor 1
    58(a)
    1 ↔ 1
    GL343662.1(186190-214023)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.201262 Xenopus laevis transcribed sequence with moderate similarity more 75.37(n)    BX851484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tacr1a1 tachykinin receptor 1a 70.82(n)
    71.32(a)
      100003539  NM_001270478.1  NP_001257407.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Takr99D3 G-protein coupled receptor protein
    signaling pathway more
    45(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea tkr-13 G protein coupled receptor 36(a)
    (best of 4)
      III(9457359-9458961)   --


    ENSEMBL Gene Tree for TACR1 (if available)
    TreeFam Gene Tree for TACR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TACR1 gene
    GPR832  HCRTR22  PRLHR2  NPFFR22  NPY5R2  NPY4R2  TACR32  NPY1R2  
    NPY2R2  NPFFR12  QRFPR2  HCRTR12  TACR22  
    15 SIMAP similar genes for TACR1 using alignment to 4 protein entries:     NK1R_HUMAN (see all proteins):
    TACR3    TACR2    hA2aR    GIR    GPR83    AGTR1
    HCRTR2    HTR5A    PRLHR    GPR1    HCRTR1    NPY2R
    OPRM1    QRFPR    GPR50

    TACR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TACR1 (see all 3182)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451247501,2
    C--75029605(+) GGTTG-/GGG   
       GTTGT
    GGGAG
    2 -- int10--------
    rs38361911,2
    C--75029608(+) TGGGG-/GTT   
       GTGGG
    AGACG
    2 -- int10--------
    rs1895421491,2
    --75061943(+) TTTTTC/TCCTAC 2 -- int10--------
    rs349603391,2
    C--75103359(+) AAATA-/ACT   
      A
    /CTAC
    CTGAG
    2 -- int10--------
    rs1459402881,2
    C--75124814(+) AATAG-/AAAAAAA 2 -- int10--------
    rs728242181,2
    C,F--75144375(+) ACCCCT/CTTTTT 1 -- int12Minor allele frequency- C:0.18NA EA 240
    rs127138271,2
    C,F,H--75144407(+) GTGGTC/TTGAAG 1 -- int120Minor allele frequency- T:0.29NS EA NA WA CSA 1210
    rs1464013751,2
    --75144487(+) TCCTAC/TGAAAA 1 -- int10--------
    rs1891404821,2
    --75144557(+) ATCACA/TGTCAT 1 -- int10--------
    rs126221831,2
    C,F,A,H--75144560(+) ACTGTC/GATTTC 1 -- int115Minor allele frequency- G:0.36NS EA NA WA 928

    HapMap Linkage Disequilibrium report for TACR1 (75273590 - 75426826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TACR1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664298CNV Deletion23128226
    esv2720214CNV Deletion23290073
    esv272151CNV Insertion20981092
    esv2489063CNV Insertion19546169
    esv1335930CNV Insertion17803354
    esv274003CNV Insertion20981092
    nsv525695CNV Loss19592680
    esv28202CNV Loss19812545
    dgv32n64CNV Loss17921354
    nsv438354CNV Loss16468122

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162323    OMIM disorders: --

    Selected diseases for TACR1 (see all 88):    
    About MalaCards
    telogen effluvium    causalgia    meningoencephalitis    motion sickness
    social phobia    fibromyalgia    trypanosomiasis    complex regional pain syndrome
    chronic pain    cystitis    measles    bronchitis
    multiple system atrophy    paine syndrome    pain agnosia    anxiety disorder
    contact dermatitis    allergic contact dermatitis    status epilepticus    dermatitis

    6 diseases from the University of Copenhagen DISEASES database for TACR1:
    Migraine     Pain agnosia     Asthma     Cystitis
    Pancreatitis     Complex regional pain syndrome

    TACR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TACR1 gene (see all 65)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 61.4 32 7516885 (3), 7512575 (2), 1328053 (2), 1378485 (1) (see all 23)
    inflammation 55.7 78 12559111 (3), 11275376 (3), 8240667 (2), 16777450 (2) (see all 55)
    hyperalgesia 53.2 19 1381521 (2), 15964684 (2), 9323204 (2), 17123731 (2) (see all 12)
    migraine 30.4 8 8846424 (2), 11281817 (1), 15155133 (1), 7536309 (1) (see all 7)
    asthma 29 13 8240667 (2), 17392578 (2), 15155133 (1), 15334652 (1) (see all 9)
    airways disease 28.2 1 7682142 (1)
    inflammatory bowel diseases 25.9 11 7529913 (2), 17368292 (1), 11073811 (1), 10940277 (1) (see all 7)
    bronchitis chronic 22.6 1 7682142 (1)
    causalgia 19.2 1 12855316 (1)
    anxiety depression 17.2 3 20074437 (1), 16983662 (1), 18600583 (1)

    Genetic Association Database (GAD): TACR1
    Human Genome Epidemiology (HuGE) Navigator: TACR1 (19 documents)

    Export disorders for TACR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TACR1 gene, integrated from 10 sources (see all 718):
    (articles sorted by number of sources associating them with TACR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PubMed id 1657150)1, 2, 3, 9 Gerard N.P.... Gerard C. (Biochemistry 1991)
    2. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. (PubMed id 18452185)1, 4, 9 Hodges L.M....Hamilton S.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    3. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. (PubMed id 1310144)1, 2, 9 Fong T.M.... Strader C.D. (Mol. Pharmacol. 1992)
    4. Molecular cloning, structural characterization and functional expression of the human substance P receptor. (PubMed id 1718267)1, 2, 9 Takeda Y.... Krause J.E. (Biochem. Biophys. Res. Commun. 1991)
    5. The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)1, 2, 9 Takahashi K.... Nakanishi S. (Eur. J. Biochem. 1992)
    6. Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. (PubMed id 20074437)1, 4, 9 Ablin J.N....Orr-Urtreger A. (Clin. Exp. Rheumatol. 2009)
    7. Tachykinin receptor 1 variants associated with aggression in suicidal behavior. (PubMed id 17443717)1, 4, 9 Giegling I....Serretti A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    8. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. (PubMed id 16893949)1, 4, 9 Park H.K....Kim Y.Y. (Thorax 2006)
    9. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PubMed id 8384323)1, 2, 9 Fong T.M.... Strader C.D. (Nature 1993)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6869 HGNC: 11526 AceView: TACR1 Ensembl:ENSG00000115353 euGenes: HUgn6869
    ECgene: TACR1 Kegg: 6869 H-InvDB: TACR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TACR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Tachykinin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TACR1 gene:
    Search GeneIP for patents involving TACR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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