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Aliases for TACR1 Gene

Aliases for TACR1 Gene

  • Tachykinin Receptor 1 2 3 4 5
  • NK-1 Receptor 3 4
  • TAC1R 3 4
  • NK-1R 3 4
  • NK1R 3 4
  • SPR 3 4
  • Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor) 3
  • NKIR 3

External Ids for TACR1 Gene

Previous HGNC Symbols for TACR1 Gene

  • TAC1R

Previous GeneCards Identifiers for TACR1 Gene

  • GC02M075413
  • GC02M075233
  • GC02M075250
  • GC02M075187
  • GC02M075129

Summaries for TACR1 Gene

Entrez Gene Summary for TACR1 Gene

  • This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

GeneCards Summary for TACR1 Gene

TACR1 (Tachykinin Receptor 1) is a Protein Coding gene. Diseases associated with TACR1 include Constipation and Cystitis. Among its related pathways are Peptide ligand-binding receptors and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include G-protein coupled receptor activity and substance P receptor activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for TACR1 Gene

  • This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

Tocris Summary for TACR1 Gene

  • The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.

Gene Wiki entry for TACR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACR1 Gene

Genomics for TACR1 Gene

Regulatory Elements for TACR1 Gene

Enhancers for TACR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TACR1 on UCSC Golden Path with GeneCards custom track

Promoters for TACR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TACR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACR1 Gene

75,046,463 bp from pter
75,199,700 bp from pter
153,238 bases
Minus strand

Genomic View for TACR1 Gene

Genes around TACR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACR1 Gene

Proteins for TACR1 Gene

  • Protein details for TACR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Substance-P receptor
    Protein Accession:
    Secondary Accessions:
    • A8K150

    Protein attributes for TACR1 Gene

    407 amino acids
    Molecular mass:
    46251 Da
    Quaternary structure:
    • Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for TACR1 Gene

    Alternative splice isoforms for TACR1 Gene


neXtProt entry for TACR1 Gene

Proteomics data for TACR1 Gene at MOPED

Post-translational modifications for TACR1 Gene

  • Glycosylation at Asn 14 and Asn 18
  • Modification sites at PhosphoSitePlus

Other Protein References for TACR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACR1 Gene

Domains & Families for TACR1 Gene

Gene Families for TACR1 Gene

Suggested Antigen Peptide Sequences for TACR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TACR1: view

Function for TACR1 Gene

Molecular function for TACR1 Gene

GENATLAS Biochemistry:
tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal but non peripheral mononuclear cells,involved in mucosal immunomodulation
UniProtKB/Swiss-Prot Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
genes like me logo Genes that share phenotypes with TACR1: view

Animal Models for TACR1 Gene

MGI Knock Outs for TACR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TACR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACR1 Gene

Localization for TACR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TACR1 Gene COMPARTMENTS Subcellular localization image for TACR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
endosome 2
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030425 dendrite IEA --
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with TACR1: view

Pathways & Interactions for TACR1 Gene

genes like me logo Genes that share pathways with TACR1: view

Gene Ontology (GO) - Biological Process for TACR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002118 aggressive behavior IEA --
GO:0002526 acute inflammatory response IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 1657150
genes like me logo Genes that share ontologies with TACR1: view

No data available for SIGNOR curated interactions for TACR1 Gene

Drugs & Compounds for TACR1 Gene

(112) Drugs for TACR1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprepitant Approved, Investigational Pharma Antagonist, antagonist, Target Substance P (SP) inhibitor 155
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 155
Vapreotide Approved, Investigational Pharma Full agonist, Agonist, Target, antagonist 2
netupitant Approved Pharma Antagonist, Target, antagonist 0
Ketamine Approved Pharma Channel blocker, Target, antagonist 480

(53) Additional Compounds for TACR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 73632
Full agonist, Agonist
Full agonist, Agonist

(5) Tocris Compounds for TACR1 Gene

Compound Action Cas Number
[Sar9,Met(O2)11]-Substance P Potent, selective NK1 agonist 110880-55-2
C14TKL-1 Endogenous NK1 agonist
GR 73632 Potent, selective NK1 agonist 133156-06-6
Hemokinin 1 (human) Endogenous, selective NK1 agonist 491851-53-7
Hemokinin 1 (mouse) Endogenous, high affinity, selective NK1 agonist 208041-90-1

(3) ApexBio Compounds for TACR1 Gene

Compound Action Cas Number
Aprepitant Substance P (SP) inhibitor 170729-80-3
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
genes like me logo Genes that share compounds with TACR1: view

Drug Products

Transcripts for TACR1 Gene

mRNA/cDNA for TACR1 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACR1 Gene

Tachykinin receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TACR1 Gene

No ASD Table

Relevant External Links for TACR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TACR1 Gene

mRNA expression in normal human tissues for TACR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACR1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.5) and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for TACR1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TACR1 Gene

SOURCE GeneReport for Unigene cluster for TACR1 Gene Hs.633301

genes like me logo Genes that share expression patterns with TACR1: view

Protein tissue co-expression partners for TACR1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TACR1 Gene

Orthologs for TACR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TACR1 35
  • 89.76 (n)
  • 94.1 (a)
NK1R 36
  • 94 (a)
(Canis familiaris)
Mammalia TACR1 35
  • 92.96 (n)
  • 97.54 (a)
TACR1 36
  • 98 (a)
(Mus musculus)
Mammalia Tacr1 35
  • 89.76 (n)
  • 94.59 (a)
Tacr1 16
Tacr1 36
  • 95 (a)
(Pan troglodytes)
Mammalia TACR1 35
  • 99.51 (n)
  • 99.75 (a)
TACR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tacr1 35
  • 89.35 (n)
  • 94.59 (a)
(Monodelphis domestica)
Mammalia TACR1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves TACR1 35
  • 78.21 (n)
  • 79.12 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia TACR1 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tacr1 35
  • 71.7 (n)
  • 74.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20126 35
(Danio rerio)
Actinopterygii tacr1a 35
  • 70.82 (n)
  • 71.32 (a)
tacr1a 36
  • 67 (a)
tacr1b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10626 37
  • 32 (a)
NepYr 37
  • 32 (a)
Takr86C 37
  • 37 (a)
Takr99D 37
  • 45 (a)
Takr86C 36
  • 24 (a)
Takr99D 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea C49A9.7 37
  • 36 (a)
C50F7.1 37
  • 28 (a)
tkr-1 37
  • 36 (a)
Y59H11AL.1 37
  • 29 (a)
tkr-1 36
  • 29 (a)
tkr-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for TACR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACR1 Gene

Gene Tree for TACR1 (if available)
Gene Tree for TACR1 (if available)

Paralogs for TACR1 Gene

(15) SIMAP similar genes for TACR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TACR1: view

Variants for TACR1 Gene

Sequence variations from dbSNP and Humsavar for TACR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_026826 -
rs713082 -- 75,046,339(+) AGAGT(C/T)AAGAG downstream-variant-500B
rs727156 -- 75,053,080(+) TGAAA(C/T)TTCAT intron-variant
rs735668 -- 75,135,918(+) TCTCC(A/C)TTTCG intron-variant
rs737679 -- 75,134,830(+) CTTTC(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACR1 Gene

Variant ID Type Subtype PubMed ID
dgv4168n71 CNV Gain 21882294
nsv834262 CNV Gain 17160897
nsv874299 CNV Gain 21882294
nsv527009 CNV Gain 19592680
nsv520917 CNV Gain 19592680
dgv32n64 CNV Loss 17921354
nsv525695 CNV Loss 19592680
nsv874300 CNV Gain 21882294
nsv874301 CNV Gain 21882294
esv2664298 CNV Deletion 23128226
dgv1200e1 CNV Complex 17122850
nsv438354 CNV Loss 16468122
esv28202 CNV Loss 19812545
esv2720214 CNV Deletion 23290073
nsv10035 CNV Gain 18304495
esv2489063 CNV Insertion 19546169
esv272151 CNV Insertion 20981092
esv274003 CNV Insertion 20981092
esv1335930 CNV Insertion 17803354

Variation tolerance for TACR1 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TACR1 Gene

Disorders for TACR1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TACR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • infective cystitis
spinocerebellar ataxia 23
  • spinocerebellar ataxia type 23
mood disorder
  • episodic mood disorder
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association - COSMIC cancer census association via MalaCards
Search TACR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TACR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACR1 Gene

Publications for TACR1 Gene

  1. Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PMID: 1657150) Gerard N.P. … Gerard C. (Biochemistry 1991) 2 3 4 67
  2. Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. (PMID: 17643344) Rodgers J. … Kennedy P.G. (Parasitol. Int. 2007) 23 25 26
  3. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. (PMID: 12784346) Poli-Bigelli S. … Lawson F. (Cancer 2003) 23 25 26
  4. Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction. (PMID: 12227806) Zhao M.M. … Bishop B.C. (J. Org. Chem. 2002) 23 25 26
  5. NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. (PMID: 19204064) Yan T.C. … Gurling H. (J. Psychopharmacol. (Oxford) 2010) 3 23

Products for TACR1 Gene

Sources for TACR1 Gene