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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TACR1 Gene

protein-coding GIFtS: 66
GCID: GC02M075187

tachykinin receptor 1

(Previous symbol: TAC1R)

Explore 89 diseases affiliated with
TACR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tachykinin Receptor 1¹ ² ³		NK-1R² ³
NK1R¹ ² ³ ⁵		NK-1 Receptor² ³
TAC1R¹ ² ³ ⁵		Substance-P Receptor²
SPR¹ ² ³		Tachykinin Receptor 1 (Substance P Receptor; Neurokinin-1 Receptor)²
NKIR¹ ²

External Ids:	HGNC: 11526¹	Entrez Gene: 6869²	Ensembl: ENSG00000115353⁷	OMIM: 162323⁵	UniProtKB: P25103³

Export aliases for TACR1 gene to outside databases

Previous GC identifers: GC02M075413 GC02M075233 GC02M075250 GC02M075129 GC02M075010

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TACR1:

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by

interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for

the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of

phosphatidylinositol metabolism of substance P. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins

that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to

tachykinins is: substance P > substance K > neuromedin-K

summary for TACR1:

The neurokinin (NK) 1 receptor is a member of the tachykinin family of G-protein-coupled receptors which

also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS

(particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues. NK1

receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission,

immune modulation and airway and lung function. The receptor displays greater potency for the endogenous

agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1

receptor has been localized on chromosome 2 (2p13.1-p12).

Gene Wiki entry for TACR1 (Tachykinin receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TACR1 gene promoter:
GR AP-1 GR-beta Nkx2-5 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TACR1 promoter sequence

Search SABiosciences Chromatin IP Primers for TACR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TACR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p12 HGNC cytogenetic band: 2p13.1-p12

TACR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACR1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M075187: view genomic region (about GC identifiers)

Start:	75,273,590 bp from pter	End:	75,426,826 bp from pter
Size:	153,237 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103 (See protein sequence)

Recommended Name: Substance-P receptor

Size: 407 amino acids; 46251 Da

Subunit: Interacts with ARRB1 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

3 PDB 3D structures from and Proteopedia for TACR1:

2KS9 (3D)

2KSA (3D)

2KSB (3D)

Secondary accessions: A8K150

Explore the universe of human proteins at neXtProt for TACR1: NX_P25103

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25103

TACR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001049.1 NP_056542.1

ENSEMBL proteins:

ENSP00000303522 ENSP00000386448

Reactome Protein details: P25103
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant TACR1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Novus Biologicals TACR1 Proteins Novus Biologicals TACR1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TACR1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1657150
GO:0009986	cell surface	IEA	--
GO:0030425	dendrite	IEA	--

TACR1 for ontologies About GeneDecksing

TACR1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TACR1
	R&D Systems Antibodies for TACR1 (NK1R)
	OriGene Antibodies (see all 2): TACR1 OriGene Custom Antibody Services for TACR1
	GenScript Custom Superior Antibodies Services for TACR1
	Novus Biologicals TACR1 Antibodies
	Search for Antibodies for TACR1 at Abcam
	Uscn Antibodies for TACR1
	ThermoFisher Antibody for TACR1

Assay Products for TACR1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript TACR1-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TACR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TACR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR001681 Neurokn_rcpt

IPR000276 GPCR_Rhodpsn

IPR000046 NK1_rcpt

Graphical View of Domain Structure for InterPro Entry P25103

ProtoNet protein and cluster: P25103

2 Blocks protein families:

IPB000046 Neurokinin NK1 receptor signature

IPB001681 Neurokinin receptor signature

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NK1R_HUMAN, P25103

Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins

that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to

tachykinins is: substance P > substance K > neuromedin-K

Genatlas biochemistry entry for TACR1:

tachykinin 1 receptor,substance P/neurokinine 1 receptor,G protein coupled receptor superfamily,expressed in mucosal

but non peripheral mononuclear cells,involved in mucosal immunomodulation

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TACR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACR1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TACR1 (see all 16):
		hsa-miR-374b* hsa-miR-3673 hsa-miR-206 hsa-miR-4307 hsa-miR-642a hsa-miR-4268 hsa-miR-222 hsa-miR-1

		SwitchGear 3'UTR luciferase reporter plasmid: TACR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACR1 (see all 7) OriGene shRNA RFP: TACR1 OriGene siRNA: TACR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TACR1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TACR1

Clone Products:		EMD Millipore Clones for the Expression of TACR1
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TACR1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TACR1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TACR1 (NM_001058)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACR1

Cell Line Products:		GenScript TACR1-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for TACR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACR1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004995	tachykinin receptor activity	TAS	8985172
GO:0005515	protein binding	IPI	17986524
GO:0016496	substance P receptor activity	IEA	--

TACR1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for TACR1:

Decreased Salmonella enterica

Decreased nuclei size in G2M

Decreased viability of wild-ty

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Tacr1^tm1Rhn for TACR1
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tacr1):

behavior/neurological	cardiovascular system	homeostasis/metabolism	immune system	integument
nervous system	respiratory system	skeleton

TACR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Tachykinin receptors bind tachykinins

Tachykinin receptors bind tachykinins

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TACR1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TACR1

	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	NK1R-mediated Non-Apoptotic PCD

2 BioSystems Pathways for TACR1

	SIDS Susceptibility Pathways
	Peptide GPCRs

5/9 Reactome Pathways for TACR1 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

3 Kegg Pathways (Kegg details for TACR1):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles

TACR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TACR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/128 Interacting proteins for TACR1 (P25103³ ENSP00000303522⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 128)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPRASP1	Q5JY77³, ENSP00000355146⁴	I2D: score=1 STRING: ENSP00000355146
TAC4	Q86UU9³, ENSP00000334042⁴	I2D: score=1 STRING: ENSP00000334042
TAC1	P20366³, ENSP00000321106⁴	I2D: score=2 STRING: ENSP00000321106
GRK5	P34947³, ENSP00000376609⁴	I2D: score=2 STRING: ENSP00000376609
UBC	P0CG48³	I2D: score=1

About this table

Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002118	aggressive behavior	IEA	--
GO:0002526	acute inflammatory response	IEA	--
GO:0002687	positive regulation of leukocyte migration	IEA	--
GO:0003051	angiotensin-mediated drinking behavior	IEA	--
GO:0006950	response to stress	--	--

TACR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TACR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for TACR1

Compounds for TACR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
RP 67580	Potent and selective NK1 antagonist	[135911-02-3]
CP 99994 dihydrochloride	High affinity NK1 antagonist	[136982-36-0]
L-733,060 hydrochloride	Potent NK1 antagonist	[148700-85-0]
CP 96345	Potent and selective NK1 antagonist	[132746-60-2]
L-732,138	Potent, selective NK1 antagonist	[148451-96-1]

2 HMDB Compounds for TACR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Substance P	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2	33507-63-0	--

4 DrugBank Compounds for TACR1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Aprepitant	MK-0517 (see all 2)	170729-80-3	target	antagonist	12227806 12784346 15121485 12590540 11752352 17643344
Fosaprepitant	--	172673-20-0	target	antagonist	12227806 12784346 15121485 11752352
Vapreotide	BMY 41606 (see all 6)	103222-11-3	target	antagonist	11752352 7556407
Ketamine	(-)-Ketamine (see all 7)	6740-88-1	target	antagonist	12818951

10/112 Novoseek chemical compound relationships for TACR1 gene (see all 112) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aprepitant	93.2	62	19148578 (4), 15485308 (2), 18208572 (2), 15813642 (2) (see all 45)
septide	90.9	55	10051129 (4), 8985159 (3), 7518302 (3), 7685292 (2) (see all 25)
fk 888	88.4	17	7531648 (4), 7504102 (2), 7516885 (2), 9399104 (1) (see all 9)
cp 96345	88.2	6	7687919 (1), 7538136 (1), 18160487 (1), 7823080 (1) (see all 6)
senktide	87.2	12	9402049 (1), 15145080 (1), 7538871 (1), 8583573 (1) (see all 11)
fk 224	84.1	5	7504102 (1), 8529964 (1), 8821532 (1), 7682142 (1) (see all 5)
palonosetron	82.7	6	17366928 (1), 16499138 (1), 20307224 (1), 16608997 (1) (see all 5)
gr 71251	81.8	6	7688874 (1), 7689402 (1), 11480541 (1), 16077032 (1)
ly303870	81.5	5	7473161 (5)
gr 82334	80.9	5	7538871 (1), 7679029 (1), 7823080 (1), 7679026 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about TACR1 / NK1R

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TACR1 gene (2 alternative transcripts):

NM_001058.3 NM_015727.2

Unigene Cluster for TACR1:

Tachykinin receptor 1

Hs.633301 [show with all ESTs]

Unigene Representative Sequence: NM_001058

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305249(uc002sng.2 uc002snh.3) ENST00000409848 ENST00000497764

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TACR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACR1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TACR1 (see all 16):
		hsa-miR-374b* hsa-miR-3673 hsa-miR-206 hsa-miR-4307 hsa-miR-642a hsa-miR-4268 hsa-miR-222 hsa-miR-1

		SwitchGear 3'UTR luciferase reporter plasmid: TACR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACR1 (see all 7) OriGene shRNA RFP: TACR1 OriGene siRNA: TACR1
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TACR1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TACR1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TACR1 (NM_001058)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACR1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TACR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TACR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TACR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACR1

Additional cDNA sequence:

AK289765.1 AY462098.1 BC074911.2 BC074912.2 BC095528.1 M74290.1 M76675.1 M81797.1

M84425.1 M84426.1 S62045.1

5 DOTS entries:

DT.309603 DT.70105091 DT.100742331 DT.432141 DT.95093567

13 AceView cDNA sequences:

AY462098 M74290 BC074912 M81797 S62045 CD246198 NM_015727 M76675

BC074911 AL120339 M84425 NM_001058 M84426

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TACR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCACAGT

About this image

TACR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TACR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TACR1

SOURCE GeneReport for Unigene cluster: Hs.633301

SABiosciences Expression via Pathway-Focused PCR Arrays including TACR1 (see all 6):

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Neurotrophins & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TACR1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TACR1 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TACR1¹	tachykinin receptor 1	78.21(n) 79.12(a)		395677 NM_204868.1 NP_990199.1
lizard (Anolis carolinensis)	Reptilia	TACR1⁶	--	58(a)	1 ↔ 1	GL343662.1(186190-213516)
African clawed frog (Xenopus laevis)	Amphibia	Xl.20126²	Xenopus laevis transcribed sequence with moderate similarity more	75.37(n)		BX851484.1
zebrafish (Danio rerio)	Actinopterygii	nk1a¹	substance-P receptor-like	72.49(n) 73.54(a)		100003539 XM_001343037.3 XP_001343073.3
fruit fly (Drosophila melanogaster)	Insecta	Takr99D³	G-protein coupled receptor protein signaling pathway more	45(a) (best of 4)		--
worm (Caenorhabditis elegans)	Secernentea	tkr-1³	G protein coupled receptor	36(a) (best of 4)		III(9457359-9458961) --

ENSEMBL Gene Tree for TACR1 (if available)
TreeFam Gene Tree for TACR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TACR1 gene

GPR83² HCRTR2² PRLHR² NPFFR2² PPYR1² NPY5R² TACR3² NPY1R²

NPFFR1² QRFPR² NPY2R² HCRTR1² TACR2²

15 SIMAP similar genes for TACR1 using alignment to 4 protein entries: NK1R_HUMAN (see all proteins):

TACR3 TACR2 hA2aR GIR GPR83 AGTR1

HTR5A PRLHR GPR1 HCRTR1 NPY2R OPRM1

QRFPR GPR50 PPYR1

TACR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193005608^1,2	C,	--	75010269(+)	`TCTCAA/GCCTGG`	1	--	int¹		0	--	--	--	--
rs75710708^1,2	C,F,	--	75010435(+)	`AGGCAC/TGAGAG`	1	--	int¹		2		WA EA	238
rs13424924^1,2	C,	--	75010462(+)	`TATTTC/ATGTAT`	1	--	ut3¹		1		WA	118
rs78425096^1,2	F,	--	75010625(+)	`TCCTGT/CTGGGG`	1	--	ut3¹		1		WA	118
rs72824221^1,2	C,	--	75011193(+)	`CCCCAG/CAGAAC`	1	--	ut3¹		2		NA	122
rs77764507^1,2		--	75011631(+)	`TCTAAA/GTTTTG`	1	--	ut3¹		1		NA	120
rs111522464^1,2		--	75012141(+)	`GAAGGG/AAAGAT`	1	--	ut3¹		2		CSA WA	120
rs59224645^1,2	C,F,	--	75012415(+)	`GGAATG/ATACTC`	1	--	ut3¹		2		WA EA	238
rs17010664^1,2	C,F,H,	--	75013140(-)	`CCCAAA/GAGCCC`	1	--	ut3¹ ese³		19		EU NS NA WA CSA	2065
rs79391873^1,2	C,F,	--	75013208(+)	`AGTCAC/AACAGC`	1	--	ut3¹		2		WA EA	238

HapMap Linkage Disequilibrium report for TACR1 (75273590 - 75426826 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TACR1
6 CNVs: 97888 9945 30954 2391 74014 1584

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TACR1 for disorders           About GeneDecksing

OMIM gene information: 162323    OMIM disorders: --

20/89 diseases for TACR1 (see all 89):    About MalaCards

telogen effluvium complex regional pain syndrome causalgia social phobia

lichen planus motion sickness allergic contact dermatitis contact dermatitis

oral lichen planus traumatic brain injury multiple system atrophy status epilepticus

allergic rhinitis anxiety disorder major depressive disorder inflammatory bowel disease

brain injury phobia meningoencephalitis irritable bowel syndrome

6 diseases from the University of Copenhagen DISEASES database for TACR1:

Pain agnosia Asthma Cystitis Migraine

Pancreatitis Motion sickness

10/65 Novoseek disease relationships for TACR1 gene (see all 65) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	61.4	32	7516885 (3), 7512575 (2), 1328053 (2), 1378485 (1) (see all 23)
inflammation	55.7	78	12559111 (3), 11275376 (3), 8240667 (2), 16777450 (2) (see all 55)
hyperalgesia	53.2	19	1381521 (2), 15964684 (2), 9323204 (2), 17123731 (2) (see all 12)
migraine	30.4	8	8846424 (2), 11281817 (1), 15155133 (1), 7536309 (1) (see all 7)
asthma	29	13	8240667 (2), 17392578 (2), 15155133 (1), 15334652 (1) (see all 9)
airways disease	28.2	1	7682142 (1)
inflammatory bowel diseases	25.9	11	7529913 (2), 17368292 (1), 11073811 (1), 10940277 (1) (see all 7)
bronchitis chronic	22.6	1	7682142 (1)
causalgia	19.2	1	12855316 (1)
anxiety depression	17.2	3	20074437 (1), 16983662 (1), 18600583 (1)

Human Genome Epidemiology (HuGE) Navigator: TACR1 (19 documents)

Export disorders for TACR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TACR1 gene, integrated from 9 sources (see all 699):
(articles sorted by number of sources associating them with TACR1)

Utopia: connect your pdf to the dynamic
world of online information

Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. (PubMed id 1657150)^{1, 2, 3, 9} Gerard N.P.... Gerard C. (1991)
Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. (PubMed id 1310144)^{1, 2, 9} Fong T.M.... Strader C.D. (1992)
Molecular cloning, structural characterization and functional expression of the human substance P receptor. (PubMed id 1718267)^{1, 2, 9} Takeda Y.... Krause J.E. (1991)
The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)^{1, 2, 9} Takahashi K.... Nakanishi S. (1992)
Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. (PubMed id 8384323)^{1, 2, 9} Fong T.M.... Strader C.D. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant. (PubMed id 15452552)^{1, 2} Randolph G.P....Duffy R.A. (2004)
The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal. (PubMed id 11864635)^{1, 2} Page N.M. and Bell N.J. (2002)
Isolation and characterisation of the human lung NK-1 receptor cDNA. (PubMed id 1659396)^{1, 2} Hopkins B.... Graham A. (1991)
Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. (PubMed id 18713853)^{1, 9} Lai J.P....Douglas S.D. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6869	HGNC: 11526	AceView: TACR1	Ensembl:ENSG00000115353	euGenes: HUgn6869
ECgene: TACR1	Kegg: 6869	H-InvDB: TACR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TACR1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Tachykinin

Intellectual Property for TACR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TACR1 gene:
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GeneCards and IP:
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tachykinin receptor 1

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