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Aliases for TACO1 Gene

Aliases for TACO1 Gene

  • Translational Activator Of Mitochondrially Encoded Cytochrome C Oxidase I 2 3
  • CCDC44 3 4 6
  • Coiled-Coil Domain-Containing Protein 44 3 4
  • Translational Activator Of Mitochondrially-Encoded Cytochrome C Oxidase I 4
  • Translational Activator Of Cytochrome C Oxidase 1 3
  • Coiled-Coil Domain Containing 44 2
  • Clone HQ0477 PRO0477p 3

External Ids for TACO1 Gene

Previous HGNC Symbols for TACO1 Gene

  • CCDC44

Previous GeneCards Identifiers for TACO1 Gene

  • GC17P059033
  • GC17P061678
  • GC17P057046

Summaries for TACO1 Gene

Entrez Gene Summary for TACO1 Gene

  • This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

GeneCards Summary for TACO1 Gene

TACO1 (Translational Activator Of Mitochondrially Encoded Cytochrome C Oxidase I) is a Protein Coding gene. Diseases associated with TACO1 include leigh syndrome with cardiomyopathy and myasthenic syndrome, acetazolamide-responsive.

UniProtKB/Swiss-Prot for TACO1 Gene

  • Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACO1 Gene

Genomics for TACO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TACO1 Gene

Start:
63,600,872 bp from pter
End:
63,608,365 bp from pter
Size:
7,494 bases
Orientation:
Plus strand

Genomic View for TACO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACO1 Gene

No data available for Regulatory Elements for TACO1 Gene

Proteins for TACO1 Gene

  • Protein details for TACO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSH4-TACO1_HUMAN
    Recommended name:
    Translational activator of cytochrome c oxidase 1
    Protein Accession:
    Q9BSH4
    Secondary Accessions:
    • B2RD21
    • Q8N3N6
    • Q9UI60

    Protein attributes for TACO1 Gene

    Size:
    297 amino acids
    Molecular mass:
    32477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TACO1 Gene

Proteomics data for TACO1 Gene at MOPED

Post-translational modifications for TACO1 Gene

  • Ubiquitination at Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for TACO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TACO1 Gene

Domains for TACO1 Gene

Suggested Antigen Peptide Sequences for TACO1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSH4

UniProtKB/Swiss-Prot:

TACO1_HUMAN :
  • Q9BSH4
Family:
  • Belongs to the TACO1 family.
genes like me logo Genes that share domains with TACO1: view

No data available for Gene Families for TACO1 Gene

Function for TACO1 Gene

Molecular function for TACO1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.

Phenotypes for TACO1 Gene

GenomeRNAi human phenotypes for TACO1:
genes like me logo Genes that share phenotypes with TACO1: view

Animal Model Products

CRISPR Products

miRNA for TACO1 Gene

miRTarBase miRNAs that target TACO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TACO1 Gene

Localization for TACO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACO1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACO1 Gene COMPARTMENTS Subcellular localization image for TACO1 gene
Compartment Confidence
mitochondrion 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for TACO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TACO1: view

Pathways for TACO1 Gene

SuperPathways for TACO1 Gene

No Data Available

Interacting Proteins for TACO1 Gene

Gene Ontology (GO) - Biological Process for TACO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with TACO1: view

No data available for Pathways by source for TACO1 Gene

Transcripts for TACO1 Gene

mRNA/cDNA for TACO1 Gene

(126) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TACO1 Gene

Translational activator of mitochondrially encoded cytochrome c oxidase I:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TACO1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACO1 Gene

No ASD Table

Relevant External Links for TACO1 Gene

GeneLoc Exon Structure for
TACO1
ECgene alternative splicing isoforms for
TACO1

Expression for TACO1 Gene

mRNA expression in normal human tissues for TACO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TACO1 Gene

This gene is overexpressed in Salivary gland (8.9), Peripheral blood mononuclear cells (7.9), and Heart (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TACO1 Gene

SOURCE GeneReport for Unigene cluster for TACO1 Gene Hs.174134

genes like me logo Genes that share expressions with TACO1: view

Expression partners for TACO1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TACO1 Gene

Orthologs for TACO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TACO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACO1 35
  • 86.76 (n)
  • 84.18 (a)
TACO1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856685 35
  • 87.32 (n)
  • 84.85 (a)
TACO1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taco1 35
  • 82.92 (n)
  • 79.93 (a)
Taco1 16
Taco1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACO1 35
  • 99.21 (n)
  • 99.33 (a)
TACO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taco1 35
  • 82.14 (n)
  • 79.64 (a)
oppossum
(Monodelphis domestica)
Mammalia TACO1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACO1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACO1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taco1 35
  • 61.02 (n)
  • 53.63 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:162204 35
  • 55.56 (n)
  • 50.81 (a)
TACO1 (1 of 2) 36
  • 40 (a)
OneToMany
TACO1 (2 of 2) 36
  • 45 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001629 35
  • 45.34 (n)
  • 31.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4957 35
  • 42.23 (n)
  • 29.66 (a)
CG4957 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y50D7A.9 35
  • 42.97 (n)
  • 30.12 (a)
taco-1 36
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL053C 35
  • 44.53 (n)
  • 28 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04378g 35
  • 47.23 (n)
  • 31.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YGR021W 35
  • 44.81 (n)
  • 31.54 (a)
-- 36
  • 26 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G25830 35
  • 45.85 (n)
  • 31 (a)
rice
(Oryza sativa)
Liliopsida Os05g0519800 35
  • 44.54 (n)
  • 32.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10169 35
  • 44.74 (n)
  • 28.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC8D2.12c 35
  • 44.62 (n)
  • 35.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10468 36
  • 19 (a)
OneToOne
Species with no ortholog for TACO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TACO1 Gene

ENSEMBL:
Gene Tree for TACO1 (if available)
TreeFam:
Gene Tree for TACO1 (if available)

Paralogs for TACO1 Gene

Selected SIMAP similar genes for TACO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TACO1: view

No data available for Paralogs for TACO1 Gene

Variants for TACO1 Gene

Sequence variations from dbSNP and Humsavar for TACO1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4310933 -- 63,600,427(+) GGCTT(A/T)AGTGC upstream-variant-2KB
rs4464139 -- 63,600,555(+) CGTTC(A/C)GAGAG upstream-variant-2KB
rs7219075 -- 63,599,872(+) tctct(C/T)ttttt upstream-variant-2KB
rs8069993 -- 63,599,162(+) ctagg(C/G)ctgtg upstream-variant-2KB
rs8075018 -- 63,600,015(+) acagg(C/T)gcgcg upstream-variant-2KB

Relevant External Links for TACO1 Gene

HapMap Linkage Disequilibrium report
TACO1
Human Gene Mutation Database (HGMD)
TACO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TACO1 Gene

Disorders for TACO1 Gene

(1) OMIM Diseases for TACO1 Gene (612958)

UniProtKB/Swiss-Prot

TACO1_HUMAN
  • Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TACO1 Gene

Relevant External Links for TACO1

Genetic Association Database (GAD)
TACO1
Human Genome Epidemiology (HuGE) Navigator
TACO1
genes like me logo Genes that share disorders with TACO1: view

No data available for Novoseek inferred disease relationships and Genatlas for TACO1 Gene

Publications for TACO1 Gene

  1. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. (PMID: 19503089) Weraarpachai W. … Shoubridge E.A. (Nat. Genet. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TACO1 Gene

Sources for TACO1 Gene

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