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TACC3 Gene

protein-coding   GIFtS: 62
GCID: GC04P001723

Transforming, Acidic Coiled-Coil Containing Protein 3

  See TACC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming, Acidic Coiled-Coil Containing Protein 31 2
ERIC-12 3
ERIC12 3
Transforming Acidic Coiled-Coil-Containing Protein 32

External Ids:    HGNC: 115241   Entrez Gene: 104602   Ensembl: ENSG000000138107   OMIM: 6053035   UniProtKB: Q9Y6A53   

Export aliases for TACC3 gene to outside databases

Previous GC identifers: GC04P001715 GC04P001684 GC04P001690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TACC3 Gene:
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor
spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role
in growth a differentiation of certain cancer cells. (provided by RefSeq, Nov 2011)

GeneCards Summary for TACC3 Gene:
TACC3 (transforming, acidic coiled-coil containing protein 3) is a protein-coding gene. Diseases associated with TACC3 include bladder cancer susceptibility, and gliosarcoma. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer

Gene Wiki entry for TACC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TACC3 gene promoter:
         p53   HTF   Nkx2-5   NF-E2   NF-E2 p45   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTACC3 promoter sequence
   Search Chromatin IP Primers for TACC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TACC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TACC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACC3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001723:  view genomic region     (about GC identifiers)

Start:
1,723,227 bp from pter      End:
1,746,898 bp from pter
Size:
23,672 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5 (See protein sequence)
Recommended Name: Transforming acidic coiled-coil-containing protein 3  
Size: 838 amino acids; 90360 Da
Subunit: Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts
with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF
Secondary accessions: Q3KQS5 Q9UMQ1

Explore the universe of human proteins at neXtProt for TACC3: NX_Q9Y6A5

Explore proteomics data for TACC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys562, Lys674
  • Modification sites at PhosphoSitePlus

  • See TACC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006333.1  
    ENSEMBL proteins: 
     ENSP00000419210   ENSP00000418727   ENSP00000326550   ENSP00000418095   ENSP00000415914  
     ENSP00000420838  

    TACC3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TACC3

     
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    antibodies-online proteins for TACC3 (3 products) 

     
    antibodies-online peptides for TACC3

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    antibodies-online kits for TACC3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007707 TACC

    Graphical View of Domain Structure for InterPro Entry Q9Y6A5

    ProtoNet protein and cluster: Q9Y6A5

    1 Blocks protein domain: IPB007707 Transforming acidic coiled-coil-containing

    UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
    Similarity: Belongs to the TACC family


    Find genes that share domains with TACC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TACC3_HUMAN, Q9Y6A5
    Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
    processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
    similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer
    Induction: Up-regulated in various cancer cell lines

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with TACC3           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TACC3:
     Cell cycle / mitosis defect  Decreased G3BP1 protein expres  Decreased TP53 protein express  Decreased viability of wild-ty 
     Decreased viability with pacli  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tacc3):
     behavior/neurological  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     normal  skeleton  tumorigenesis 

    Find genes that share phenotypes with TACC3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TACC3: Tacc3tm1.2Tno Tacc3tm1Jni

       genOway: Develop your customized and physiologically relevant rodent model for TACC3

    miRNA
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    miRTarBase miRNAs that target TACC3:
    hsa-mir-149-5p (MIRT045607), hsa-mir-324-3p (MIRT042910), hsa-mir-324-5p (MIRT043259), hsa-mir-18a-3p (MIRT040904), hsa-mir-769-3p (MIRT039103), hsa-mir-744-5p (MIRT037681), hsa-mir-193b-3p (MIRT016566)

    Block miRNA regulation of human, mouse, rat TACC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TACC3:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidTACC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TACC3
    Predesigned siRNA for gene silencing in human, mouse, rat TACC3

    Gene Editing
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    Sino Biological Human cDNA Clone for TACC3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACC3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TACC3_HUMAN, Q9Y6A5: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with TACC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TACC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2RNA transport
    RNA transport
    3Notch Signaling Pathways
    Notch Signaling Pathways
    4Aurora A signaling
    Aurora A signaling


    Find genes that share SuperPaths with TACC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TACC3
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for TACC3
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for TACC3
        Aurora A signaling



    1 Kegg Pathway  (Kegg details for TACC3):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TACC3
    Interactions:

        Search GeneGlobe Interaction Network for TACC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for TACC3 (Q9Y6A51, 2, 3 ENSP000003265504) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKAP5Q140081, 2, 3, ENSP000003465664EBI-2554984,EBI-310585 MINT-8145000 MINT-8144928 MINT-8144977 MINT-8145261 MINT-8145016 MINT-8145273 I2D: score=3 STRING: ENSP00000346566
    CLTAP094961, 2, 3, ENSP000002422854EBI-2554984,EBI-1171169 MINT-8144928 MINT-8145261 MINT-8151296 MINT-8145273 I2D: score=1 STRING: ENSP00000242285
    KAT2AQ928303, ENSP000002259164I2D: score=2 STRING: ENSP00000225916
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0001666response to hypoxia IEA--
    GO:0006950response to stress ----
    GO:0008283cell proliferation ----
    GO:0021987cerebral cortex development IEA--

    Find genes that share ontologies with TACC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TACC3

    1 Novoseek inferred chemical compound relationship for TACC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 9.08 2 17545617 (1)



    Find genes that share compounds with TACC3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TACC3 gene: 
    NM_006342.2  

    Unigene Cluster for TACC3:

    Transforming, acidic coiled-coil containing protein 3
    Hs.104019  [show with all ESTs]
    Unigene Representative Sequence: NM_006342
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485989 ENST00000484651(uc010ibz.3) ENST00000467746 ENST00000313288(uc003gdo.3 uc003gdp.3)
    ENST00000493975 ENST00000458173 ENST00000470136 ENST00000466077 ENST00000470808
    ENST00000484264
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TACC3:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidTACC3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TACC3
      QuantiFast Probe-based Assays in human, mouse, rat TACC3

    Additional mRNA sequence: 

    AF093543.1 AF479620.1 AJ243997.1 AK225631.1 AK302463.1 AK304579.1 AK310660.1 BC106071.1 
    BC111771.1 U38441.1 

    10 DOTS entries:

    DT.445189  DT.92439981  DT.92439982  DT.95351311  DT.97824856  DT.100668137  DT.95351308  DT.100700633 
    DT.86848730  DT.97812662 

    Selected AceView cDNA sequences (see all 258):

    BF797521 BU528229 BU167788 AL134877 BG677631 CK905196 AA357042 BM710733 
    AW510471 AW079497 BF875023 BQ932141 CR621870 BI869396 BF513039 AA649020 
    BE552327 BQ230086 AA355718 CR591833 AI090599 CR624101 CR606211 AI460042 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                                                     -     -     -                 -                 -                           
    SP2:                                                                                -     -                 -                 -                           
    SP3:                                                                                                                                                      
    SP4:              -     -                                                                                                                                 
    SP5:                                                                                                        -                                             


    ECgene alternative splicing isoforms for TACC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TACC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAATAAA
    TACC3 Expression
    About this image


    TACC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Medulla Oblongata
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
    TACC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TACC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104019
        Custom PCR Arrays for TACC3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TACC3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacc31 , 5 transforming, acidic coiled-coil containing protein more1, 5 74.34(n)1
    69.48(a)1
      5 (17.83 cM)5
    213351  NM_001040435.21  NP_001035525.11 
     336581285 
    chicken
    (Gallus gallus)
    Aves TACC31 transforming, acidic coiled-coil containing protein more 54.61(n)
    47.59(a)
      422899  NM_001004429.2  NP_001004429.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia masking2 CPEB-associated factor Maskin 75.78(n)    AF200212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb5002 Danio rerio transforming acidic coiled coil 3 protein more 74.93(n)    AY170618.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tacc6
    transforming acidic coiled-coil protein
    9(a)
    1 → many
    3R(559376-574778)


    ENSEMBL Gene Tree for TACC3 (if available)
    TreeFam Gene Tree for TACC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TACC3 gene
    TACC22  TACC12  
    2 SIMAP similar genes for TACC3 using alignment to 7 protein entries:     TACC3_HUMAN (see all proteins):
    ERIC-1s    TACC2

    Find genes that share paralogs with TACC3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TACC3
    PGOHUM00000242640 PGOHUM00000234848


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TACC3 (see all 1014)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs762194001,2
    C,F--1694297(+) CTAAGC/GAGCTT 1 -- int11Minor allele frequency- G:0.13NA 120
    rs1891846211,2
    --1694592(+) TGAAGA/GAGAAA 1 -- int10--------
    rs1930524601,2
    --1694637(+) GGGAAC/TAGTCA 1 -- int10--------
    rs7987411,2
    C,F,A,H--1694682(+) cttaaG/Agtgaa 1 -- int123Minor allele frequency- A:0.33NS EA NA WA CSA 2354
    rs7987421,2
    C,F--1694871(+) tgaaaC/Tcctgt 1 -- int12Minor allele frequency- T:0.04NA MN 186
    rs1853577461,2
    --1694910(+) GGCGCC/GGTGGC 1 -- int10--------
    rs1872446931,2
    --1695081(+) AAAGGC/TAGTTT 1 -- int10--------
    rs1150550491,2
    C,F--1695087(+) AGTTTC/ATTGCA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs792105731,2
    C,F--1695101(+) TTCCGC/TGCTCA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1917016591,2
    --1695159(+) TTTTCC/GTTTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TACC3 (1723227 - 1746898 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TACC3 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv290066CNV Insertion16902084
    nsv508989CNV Insertion20534489
    dgv5416n71CNV Loss21882294
    nsv878347CNV Loss21882294
    nsv470000CNV Loss18288195
    nsv878393CNV Loss21882294
    dgv5415n71CNV Loss21882294
    nsv822437CNV Loss20364138
    nsv878400CNV Loss21882294
    nsv878328CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605303   
    OMIM disorders: 109800  
    3 diseases for TACC3:    
    About MalaCards
    bladder cancer susceptibility    gliosarcoma    giant cell glioblastoma


    Find genes that share disorders with TACC3           About GenesLikeMe

    3 Novoseek inferred disease relationships for TACC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 20.9 6 15918899 (4)
    cancer 9.64 9 10366448 (2), 17545617 (1), 17675670 (1), 15918899 (1)
    tumors 2.02 18 15918899 (4), 16930330 (3), 17545617 (2), 16773180 (1) (see all 6)

    Genetic Association Database (GAD): TACC3
    Human Genome Epidemiology (HuGE) Navigator: TACC3 (4 documents)

    Export disorders for TACC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TACC3 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with TACC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PubMed id 17675670)1, 3, 9 Schneider L....Piekorz R.P. (J. Biol. Chem. 2007)
    2. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PubMed id 10366448)1, 2, 9 Still I.H.... Cowell J.K. (Genomics 1999)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PubMed id 20972438)1, 4 Rothman N....Chanock S.J. (Nat. Genet. 2010)
    5. A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. (PubMed id 20348956)1, 4 Kiemeney L.A....Stefansson K. (Nat. Genet. 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2 Gangisetty O.... Still I.H. (Oncogene 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Characterization and localization of expression of an erythropoietin- induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. (PubMed id 11298601)1, 2 McKeveney P.J.... Maxwell A.P. (Br. J. Haematol. 2001)
    10. TACC3 expression is tightly regulated during early differentiation. (PubMed id 12711550)1, 9 Sadek C.M....Gustafsson J.A. (Gene Expr. Patterns 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10460 HGNC: 11524 AceView: TACC3 Ensembl:ENSG00000013810 euGenes: HUgn10460
    ECgene: TACC3 Kegg: 10460 H-InvDB: TACC3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TACC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TACC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TACC3 gene:
    Search GeneIP for patents involving TACC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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