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TACC3 Gene

protein-coding   GIFtS: 56

GC04P001690
transforming, acidic coiled-coil containing protein 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ERIC-1 3
ERIC1 1, 2, 3
MGC117382 2
MGC133242 2
Descriptions
transforming, acidic coiled-coil containing protein 3 2
External Ids
HGNC: 115241
Entrez Gene: 104602
UniProtKB: Q9Y6A53
Ensembl: ENSG000000138107
Search outside databases for aliases for TACC3 gene

Previous GC identifers: GC04P001715 GC04P001684

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TACC3:
The function of this gene has not yet been determined; however, it is speculated that it may be
involved in cell growth and differentiation. Expression of this gene is up-regulated in some
cancer cell lines, and in embryonic day 15 in mice. [provided by RefSeq]

UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM)
of neural progenitors (By similarity). May be involved in the control of cell growth and
differentiation. May contribute to cancer

Gene Wiki entry for TACC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TACC3 gene  

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TACC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001690:     (about GC identifiers)

Start:
1,693,054 bp from pter
End:
1,716,696 bp from pter
Size:
23,643 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_006081.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5 (See protein sequence)
Recommended Name: Transforming acidic coiled-coil-containing protein 3  
Size: 838 amino acids; 90360 Da
Subunit: Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus
region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity).
Interacts with GCN5L2 and PCAF
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q3KQS5 Q9UMQ1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006333.1  

    ENSEMBL proteins: 
    ENSP00000345465 ENSP00000326550 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TACC3)
    Human Recombinant Proteins from Abnova (TACC3)
                  OriGene Purified Recombinant Human Protein: TACC3 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for TACC3: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of TACC3
    Sigma-Aldrich Antibodies for TACC3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TACC3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TACC3)
    Novus Biologicals Antibodies for TACC3

    Assays for TACC3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR007707 TACC


       GeneDecks  TACC3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y6A5

    ProtoNet protein and cluster: Q9Y6A5

    1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing

    UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
    Similarity: Belongs to the TACC family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACC3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACC3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006342

                  Applied Biosystems Silencer® siRNAs for TACC3

                  Sigma-Aldrich siRNA and siRNA Panels for TACC3  
                         Sigma-Aldrich shRNA for TACC3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006342
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006342
                                     untagged cDNA clone in CMV expression vector: NM_006342 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006342

    UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
    Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
    Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM)
    of neural progenitors (By similarity). May be involved in the control of cell growth and
    differentiation. May contribute to cancer
    Induction: Up-regulated in various cancer cell lines

    12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tacc3):

    behavior/neurologicalcellularcraniofacialembryogenesisgrowth/size
    hematopoietic systemimmune systemlethality-prenatal/perinatallimbs/digits/tailliver/biliary system
    normalskeleton

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019904 protein domain specific binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226 microtubule cytoskeleton organization IEA--
    GO:0006950 response to stress IEA--
    GO:0008283 cell proliferation IEA--
    GO:0021987 cerebral cortex development IEA--
    GO:0022008 neurogenesis IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TACC3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TACC3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TACC3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006342

                  Sigma-Aldrich siRNA and siRNA Panels for TACC3  
                         Sigma-Aldrich shRNA for TACC3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006342  

    REFSEQ mRNAs for TACC3 gene: 

    NM_006342.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006342  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006342
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006342
                                     untagged cDNA clone in CMV expression vector: NM_006342 

    Additional cDNA sequence: 

    AF093543.1 AF479620.1 AJ243997.1 AK225631.1 AK302463.1 AK304579.1 AK310660.1 BC106071.1 
    BC111771.1 CR591833.1 CR606211.1 CR621870.1 CR624101.1 U38441.1 

    10 DOTS entries:

    DT.445189  DT.92439981  DT.92439982  DT.95351311  DT.97824856  DT.97812662  DT.100668137  DT.95351308 
    DT.100700633  DT.86848730 

    24/258 AceView cDNA sequences (see all 258 ):

    AI090599 BI869396 BG677631 AA355718 AW510471 AW079497 BQ932141 AA357042 
    BQ230086 AA649020 AL134877 BF513039 CR621870 AI460042 BF875023 BM710733 
    BE552327 BU528229 CR624101 CK905196 BU167788 CR606211 BF797521 CR591833 

    highest scoring ESTs for TACC3:

    AA070367 AA173269 AA283655 AA634563 AA641255 AA642322 AA724798 AA741066 AA761253 AF093543 

    Unigene Cluster for TACC3:

    Transforming, acidic coiled-coil containing protein 3
    Hs.104019  [show with all ESTs]
    Unigene Representative Sequence: BC106071


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 (see all 7 )

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                                                     -     -     -                 -                 -                           
    SP2:                                                                                -     -                 -                 -                           
    SP3:                                                                                                                                                      
    SP4:              -     -                                                                                                                                 
    SP5:                                                                                                        -                                             

    About this scheme

    ECgene alternative splicing isoforms for TACC3

    2 Ensembl transcripts including schematic representations:
    ENST00000343760  ENST00000313288  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TACC3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TACC3

    1 / 2 / 3

    3 probe-sets matching TACC3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    52238_s_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI990642 0.80 1.00 0.91 1

    218308_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006342 0.60 1.00 0.82 1

    218308_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACTCAATAAA

    SOURCE GeneReport for Unigene cluster: Hs.104019
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TACC3 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TACC31   -- transforming, acidic coiled-coil containing protein more 72.16(n)
    67.5(a)
    479079  XM_536226.2  XP_536226.2 
    cow
    (Bos taurus)
    TACC31   -- transforming, acidic coiled-coil containing protein more 68.79(n)
    58.75(a)
    506194  XM_582609.3  XP_582609.3 
    rat
    (Rattus norvegicus)
    Tacc31   -- transforming, acidic coiled-coil containing protein more 70.96(n)
    67.83(a)
    360962  NM_001004424.1  NP_001004424.1 
    mouse
    (Mus musculus)
    Tacc31, 5 55
    transforming, acidic coiled-coil containing protein more1, 5 67.4(n)1
    61.06(a)1
    213351  NM_001040435.21  NP_001035525.11 
     AF0935425  AF1569345  (see all 21)
    chicken
    (Gallus gallus)
    TACC31   -- transforming, acidic coiled-coil containing protein more 54.89(n)
    48.16(a)
    422899  NM_001004429.1  NP_001004429.1 
    About this table        Species with no ortholog for TACC3

    ENSEMBL Gene Tree for TACC3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TACC3 gene
    TACC22  TACC12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/178 NCBI SNPs in TACC3 are shown (see all 178 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 125)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs83891,2
    A,C,F,H1716642(+) TTTTTT/AAAAAC 1 -- ut315Minor allele frequency- A:0.24MN EU EA WA 511
    rs10637431,2
    C,F,H1699786(+) CAGATG/AGCACT 1 S/G mis1 ese39Minor allele frequency- A:0.29MN EU EA WA 1024
    rs176808811,2
    C,F,H1702776(+) GCAGGA/GGCAGC 1 G/E mis1 ese312Minor allele frequency- G:0.49NA EU EA WA 1042
    --
    rs342052381,2
    C,F1699354(-) AGACTC/TGCTGG 1 E/K mis15Minor allele frequency- T:0.05NA EU EA WA 496
    rs171320471,2
    F1699751(+) GGGCTA/GCCCTG 1 C/Y mis1 ese31Minor allele frequency- G:0.18MN 184
    rs7987571,2
    C,F,H1700013(+) TCCGGC/GCTCAA 1 G/G syn1 ese39Minor allele frequency- G:0.11MN EU EA WA 1024
    rs7987591,2
    C,F,H1700097(+) GGAGCA/GGGAGA 1 A/A syn1 ese310Minor allele frequency- G:0.27MN EU EA WA NA 1100
    rs7987581,2
    C,F,H1700052(-) GCCTTT/CTGCTG 1 Q/Q syn15Minor allele frequency- C:0.02EU EA WA NA 494
    rs10637421,2
    C,F,H1699458(+) GGCAGC/TCCTGA 1 S/S syn1 ese36Minor allele frequency- T:0.20MN EU EA WA NA 682
    rs112480731,2
    C,F,H1707300(+) AAGTTC/TGACCC 1 F/F syn18Minor allele frequency- T:0.40NA EU EA WA 570
    About this table

    HapMap Linkage Disequilibrium images for TACC3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605303

    3 Novoseek disease relationships for TACC3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 23.04 6 15918899 (4)
    cancer 12.14 9 10366448 (2), 17545617 (1), 17675670 (1), 15918899 (1)
    tumors 4.25 18 15918899 (4), 16930330 (3), 17545617 (2), 16773180 (1) (see all 6)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/34 PubMed articles for TACC3 gene (see all 34 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10460 HGNC: 11524 AceView: TACC3 Ensembl:ENSG00000013810 euGenes: HUgn10460
    ECgene: TACC3 H-InvDB: TACC3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for TACC3 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TACC3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TACC3 Browse small molecules at Sigma-Aldrich
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     Purified proteins from HEK293T cells
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for TACC3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
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