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Aliases & Descriptions for TACC3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ERIC-1 3 | | ERIC1 1, 2, 3 | | MGC117382 2 | | MGC133242 2 |
| | | Descriptions |
|---|
| transforming, acidic coiled-coil containing protein 3 2 |
|
| | Search outside databases for aliases for TACC3 genePrevious GC identifers: GC04P001715 GC04P001684 |
Summaries for TACC3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TACC3: The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. [provided by RefSeq] UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancerGene Wiki entry for TACC3 |
Genomic Location for TACC3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TACC3 gene 
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3TACC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P001690:
(about GC identifiers)
Start:
|
1,693,054 bp from pter |
End:
|
1,716,696 bp from pter |
Size:
|
23,643 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_006081.18
| Proteins for TACC3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5 (See
protein sequence)Recommended Name: Transforming acidic coiled-coil-containing protein 3 Size: 838 amino acids; 90360 Da
Subunit: Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q3KQS5 Q9UMQ1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006333.1
ENSEMBL proteins: ENSP00000345465 ENSP00000326550
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TACC3 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for TACC3: Assays for TACC3: | Protein
Domains/ Families for TACC3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y6A5
ProtoNet protein and cluster: Q9Y6A5 1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing
UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5Similarity: Belongs to the TACC family | Gene Function for TACC3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006342
Applied Biosystems Silencer® siRNAs for TACC3
Sigma-Aldrich siRNA and siRNA Panels for TACC3  Sigma-Aldrich shRNA for TACC3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006342                                  untagged cDNA clone in CMV expression vector: NM_006342 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006342
UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancerInduction: Up-regulated in various cancer cell lines12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Tacc3):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019904 | protein domain specific binding |
IEA | -- | About this table | Pathways & Interactions for TACC3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
): About this table
|
Drugs & Compounds for TACC3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TACC3
|
Transcripts for TACC3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006342
Sigma-Aldrich siRNA and siRNA Panels for TACC3  Sigma-Aldrich shRNA for TACC3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006342 REFSEQ mRNAs for TACC3 gene: NM_006342.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006342               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006342                                  untagged cDNA clone in CMV expression vector: NM_006342  Additional cDNA sequence: AF093543.1 AF479620.1 AJ243997.1 AK225631.1 AK302463.1 AK304579.1 AK310660.1 BC106071.1 BC111771.1 CR591833.1 CR606211.1 CR621870.1 CR624101.1 U38441.1 10 DOTS entries: DT.445189 DT.92439981 DT.92439982 DT.95351311 DT.97824856 DT.97812662 DT.100668137 DT.95351308 DT.100700633 DT.86848730 24/258 AceView cDNA sequences (see all 258
):AI090599 BI869396 BG677631 AA355718 AW510471 AW079497 BQ932141 AA357042 BQ230086 AA649020 AL134877 BF513039 CR621870 AI460042 BF875023 BM710733 BE552327 BU528229 CR624101 CK905196 BU167788 CR606211 BF797521 CR591833
highest scoring ESTs for TACC3:AA070367 AA173269 AA283655 AA634563 AA641255 AA642322 AA724798 AA741066 AA761253 AF093543 Unigene Cluster for TACC3: Transforming, acidic coiled-coil containing protein 3 Hs.104019 [show with all ESTs]Unigene Representative Sequence: BC106071
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TACC3
2 Ensembl transcripts including schematic representations: ENST00000343760
ENST00000313288
|
Expression for TACC3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TACC3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TACC3
1 / 2 / 3 3 probe-sets matching TACC3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTCAATAAA
SOURCE GeneReport for Unigene cluster: Hs.104019
|
Orthologs for TACC3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TACC3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for TACC3
ENSEMBL Gene Tree for TACC3 | Paralogs for TACC3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TACC3 gene
- TACC22 TACC12
|
SNPs/Variants for TACC3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TACC3 (up to first 250kb)
|
Disorders & Mutations for TACC3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605303
3 Novoseek disease relationships for TACC3 gene
About this table
|
Medical News for TACC3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TACC3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/34 PubMed articles for TACC3 gene (see all 34
):- The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PubMed id 17675670)1, 2, 3 Schneider L....Piekorz R.P. (2007)
- The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PubMed id 10366448)1, 3, 4 Still I.H.... Cowell J.K. (1999)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)3, 4 Gangisetty O.... Still I.H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Characterization and localization of expression of an erythropoietin- induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. (PubMed id 11298601)3, 4 McKeveney P.J.... Maxwell A.P. (2001)
- TACC3 expression is tightly regulated during early differentiation. (PubMed id 12711550)1, 3 Sadek C.M....Gustafsson J.A. (2003)
- Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. (PubMed id 19148534)1, 3 Yim E.K....Park J.S. (2009)
- The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. (PubMed id 11847113)1, 3 Piekorz R.P....Ihle J.N. (2002)
|
Search for TACC3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TACC3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TACC3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TACC3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TACC3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TACC3:

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Incremental update: 13 Oct 2009
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