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Aliases for TACC3 Gene

Aliases for TACC3 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 3 2 3 5
  • ERIC-1 3 4
  • ERIC1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 3 2
  • Transforming Acidic Coiled-Coil-Containing Protein 3 3

External Ids for TACC3 Gene

Previous GeneCards Identifiers for TACC3 Gene

  • GC04P001715
  • GC04P001684
  • GC04P001690

Summaries for TACC3 Gene

Entrez Gene Summary for TACC3 Gene

  • This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

GeneCards Summary for TACC3 Gene

TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Giant Cell Glioblastoma and Gliosarcoma. Among its related pathways are Aurora A signaling and DNA Damage. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot for TACC3 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

Gene Wiki entry for TACC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC3 Gene

Genomics for TACC3 Gene

Regulatory Elements for TACC3 Gene

Enhancers for TACC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F001751 1.5 FANTOM5 Ensembl ENCODE 9.2 +31.4 31431 3.8 ZFP64 ARID4B DMAP1 ZNF48 GLIS2 ZNF263 SP3 SP5 NFYC MXD4 FAM53A TACC3 FGFR3 GC04M001751 GC04P001740
GH04F001745 1.3 Ensembl ENCODE 10.5 +26.6 26572 5.1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF143 FAM53A TMEM129 TACC3 SLBP GC04M001751 GC04P001740
GH04F001693 0.9 ENCODE 13.5 -28.0 -28008 0.9 HDGF HDAC1 CBX3 ARID4B SIN3A ZNF48 RAD21 ZNF143 ZNF654 CEBPB TACC3 TMEM129 GC04P001691 GC04M001697
GH04F001719 1.1 ENCODE 10.7 +0.8 782 5.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FAM53A TMEM129 TACC3 SLBP CRIPAK ENSG00000233799 GC04P001740
GH04F001725 0.9 ENCODE 9.9 +5.7 5651 3.8 HDGF TBL1XR1 ARID4B SIN3A ZNF48 ZNF2 RAD21 GLIS2 ZNF143 ZNF207 FAM53A TMEM129 CTBP1-AS2 SLBP HAUS3 TACC3 GC04P001740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TACC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACC3 Gene

Chromosome:
4
Start:
1,721,490 bp from pter
End:
1,745,178 bp from pter
Size:
23,689 bases
Orientation:
Plus strand

Genomic View for TACC3 Gene

Genes around TACC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC3 Gene

Proteins for TACC3 Gene

  • Protein details for TACC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6A5-TACC3_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 3
    Protein Accession:
    Q9Y6A5
    Secondary Accessions:
    • Q2NKK4
    • Q3KQS5
    • Q9UMQ1

    Protein attributes for TACC3 Gene

    Size:
    838 amino acids
    Molecular mass:
    90360 Da
    Quaternary structure:
    • Interacts with microtubules. Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274). Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF (PubMed:14767476).

neXtProt entry for TACC3 Gene

Post-translational modifications for TACC3 Gene

  • Ubiquitination at Lys 562 and Lys 674
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TACC3 Gene

Domains & Families for TACC3 Gene

Protein Domains for TACC3 Gene

Suggested Antigen Peptide Sequences for TACC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6A5

UniProtKB/Swiss-Prot:

TACC3_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC3: view

No data available for Gene Families for TACC3 Gene

Function for TACC3 Gene

Molecular function for TACC3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).
UniProtKB/Swiss-Prot Induction:
Up-regulated in various cancer cell lines.

Gene Ontology (GO) - Molecular Function for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
genes like me logo Genes that share ontologies with TACC3: view
genes like me logo Genes that share phenotypes with TACC3: view

Animal Models for TACC3 Gene

MGI Knock Outs for TACC3:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACC3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC3 Gene

Localization for TACC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In complex with CKAP5 localized to microtuble plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269 PubMed:25596274}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TACC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005815 microtubule organizing center IEA --
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with TACC3: view

Pathways & Interactions for TACC3 Gene

genes like me logo Genes that share pathways with TACC3: view

Pathways by source for TACC3 Gene

1 Cell Signaling Technology pathway for TACC3 Gene
1 BioSystems pathway for TACC3 Gene
1 KEGG pathway for TACC3 Gene
1 R&D Systems pathway for TACC3 Gene

Gene Ontology (GO) - Biological Process for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0007091 metaphase/anaphase transition of mitotic cell cycle IMP 23532825
GO:0008283 cell proliferation IBA --
GO:0021987 cerebral cortex development IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TACC3: view

No data available for SIGNOR curated interactions for TACC3 Gene

Drugs & Compounds for TACC3 Gene

(1) Drugs for TACC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TACC3: view

Transcripts for TACC3 Gene

Unigene Clusters for TACC3 Gene

Transforming, acidic coiled-coil containing protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TACC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for TACC3 Gene

GeneLoc Exon Structure for
TACC3
ECgene alternative splicing isoforms for
TACC3

Expression for TACC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TACC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC3 Gene

This gene is overexpressed in Whole Blood (x17.5) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TACC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Monocytes (11.2), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TACC3 Gene



Protein tissue co-expression partners for TACC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TACC3 Gene:

TACC3

SOURCE GeneReport for Unigene cluster for TACC3 Gene:

Hs.104019
genes like me logo Genes that share expression patterns with TACC3: view

No data available for mRNA Expression by UniProt/SwissProt for TACC3 Gene

Orthologs for TACC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC3 34 35
  • 95.98 (n)
mouse
(Mus musculus)
Mammalia Tacc3 34 16 35
  • 74.34 (n)
rat
(Rattus norvegicus)
Mammalia Tacc3 34
  • 73.58 (n)
cow
(Bos Taurus)
Mammalia TACC3 34 35
  • 69.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TACC3 35
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACC3 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC3 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC3 34 35
  • 54.61 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc3 34
  • 57.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia masking 34
zebrafish
(Danio rerio)
Actinopterygii tacc3 34 35
  • 50.98 (n)
sbcb500 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5601 34
fruit fly
(Drosophila melanogaster)
Insecta tacc 35
  • 9 (a)
OneToMany
Species where no ortholog for TACC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC3 Gene

ENSEMBL:
Gene Tree for TACC3 (if available)
TreeFam:
Gene Tree for TACC3 (if available)

Paralogs for TACC3 Gene

Paralogs for TACC3 Gene

(2) SIMAP similar genes for TACC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TACC3 Gene

genes like me logo Genes that share paralogs with TACC3: view

Variants for TACC3 Gene

Sequence variations from dbSNP and Humsavar for TACC3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10015712 -- 1,741,425(+) ACCCT(G/T)GTGTC intron-variant
rs10022431 -- 1,739,258(+) AGCAG(A/C)GATCA intron-variant
rs10024257 -- 1,741,236(+) TGTGA(C/T)AGACG intron-variant
rs10024582 -- 1,741,606(+) CTCAA(C/T)GCCTC intron-variant
rs10030268 -- 1,721,132(+) TGGGA(A/G)ATGCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TACC3 Gene

Variant ID Type Subtype PubMed ID
nsv949756 CNV deletion 24416366
nsv593316 CNV gain 21841781
nsv508989 CNV insertion 20534489
nsv470000 CNV loss 18288195
nsv428434 CNV gain 18775914
nsv290066 CNV insertion 16902084
nsv1161027 CNV deletion 26073780
esv3563250 CNV deletion 23714750
esv2759218 CNV gain 17122850
dgv8901n54 CNV loss 21841781

Variation tolerance for TACC3 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC3 Gene

Disorders for TACC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TACC3 Gene - From: Orphanet

Disorder Aliases PubMed IDs
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search TACC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACC3

Genetic Association Database (GAD)
TACC3
Human Genome Epidemiology (HuGE) Navigator
TACC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACC3
genes like me logo Genes that share disorders with TACC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC3 Gene

Publications for TACC3 Gene

  1. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PMID: 17675670) Schneider L. … Piekorz R.P. (J. Biol. Chem. 2007) 2 3 22 64
  2. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PMID: 10366448) Still I.H. … Cowell J.K. (Genomics 1999) 3 4 22 64
  3. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. (PMID: 23532825) Cheeseman L.P. … Royle S.J. (J. Cell Sci. 2013) 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. (PMID: 21297582) Booth D.G. … Royle S.J. (EMBO J. 2011) 3 4 64

Products for TACC3 Gene

Sources for TACC3 Gene

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