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Aliases for TACC3 Gene

Aliases for TACC3 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 3 2 3
  • Transforming, Acidic Coiled-Coil Containing Protein 3 2 3 5
  • ERIC-1 3 4
  • ERIC1 3 4

External Ids for TACC3 Gene

Previous GeneCards Identifiers for TACC3 Gene

  • GC04P001715
  • GC04P001684
  • GC04P001690

Summaries for TACC3 Gene

Entrez Gene Summary for TACC3 Gene

  • This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]

GeneCards Summary for TACC3 Gene

TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include gliosarcoma and giant cell glioblastoma. Among its related pathways are RNA transport and Notch Signaling Pathways. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot for TACC3 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer.

Gene Wiki entry for TACC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC3 Gene

Genomics for TACC3 Gene

Regulatory Elements for TACC3 Gene

Promoters for TACC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TACC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACC3 Gene

Chromosome:
4
Start:
1,721,490 bp from pter
End:
1,745,178 bp from pter
Size:
23,689 bases
Orientation:
Plus strand

Genomic View for TACC3 Gene

Genes around TACC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC3 Gene

Proteins for TACC3 Gene

  • Protein details for TACC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6A5-TACC3_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 3
    Protein Accession:
    Q9Y6A5
    Secondary Accessions:
    • Q2NKK4
    • Q3KQS5
    • Q9UMQ1

    Protein attributes for TACC3 Gene

    Size:
    838 amino acids
    Molecular mass:
    90360 Da
    Quaternary structure:
    • Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF.

neXtProt entry for TACC3 Gene

Proteomics data for TACC3 Gene at MOPED

Post-translational modifications for TACC3 Gene

  • Ubiquitination at Lys 562 and Lys 674
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TACC3 (TACC3)

No data available for DME Specific Peptides for TACC3 Gene

Domains & Families for TACC3 Gene

Protein Domains for TACC3 Gene

Suggested Antigen Peptide Sequences for TACC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6A5

UniProtKB/Swiss-Prot:

TACC3_HUMAN :
  • Belongs to the TACC family.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC3: view

No data available for Gene Families for TACC3 Gene

Function for TACC3 Gene

Molecular function for TACC3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer.
UniProtKB/Swiss-Prot Induction:
Up-regulated in various cancer cell lines.
genes like me logo Genes that share phenotypes with TACC3: view

Animal Models for TACC3 Gene

MGI Knock Outs for TACC3:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC3 Gene

Localization for TACC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACC3 Gene COMPARTMENTS Subcellular localization image for TACC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TACC3 Gene

Pathways & Interactions for TACC3 Gene

genes like me logo Genes that share pathways with TACC3: view

Pathways by source for TACC3 Gene

1 BioSystems pathway for TACC3 Gene
1 KEGG pathway for TACC3 Gene
1 R&D Systems pathway for TACC3 Gene

Gene Ontology (GO) - Biological Process for TACC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0021987 cerebral cortex development IBA --
genes like me logo Genes that share ontologies with TACC3: view

No data available for SIGNOR curated interactions for TACC3 Gene

Drugs & Compounds for TACC3 Gene

(1) Drugs for TACC3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TACC3: view

Transcripts for TACC3 Gene

Unigene Clusters for TACC3 Gene

Transforming, acidic coiled-coil containing protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for TACC3 Gene

GeneLoc Exon Structure for
TACC3
ECgene alternative splicing isoforms for
TACC3

Expression for TACC3 Gene

mRNA expression in normal human tissues for TACC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC3 Gene

This gene is overexpressed in Whole Blood (x17.5) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TACC3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9), Monocytes (11.2), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TACC3 Gene



SOURCE GeneReport for Unigene cluster for TACC3 Gene Hs.104019

genes like me logo Genes that share expression patterns with TACC3: view

Protein tissue co-expression partners for TACC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TACC3 Gene

Orthologs for TACC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACC3 35
  • 69.15 (n)
  • 59.14 (a)
TACC3 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacc3 35
  • 74.34 (n)
  • 69.48 (a)
Tacc3 16
Tacc3 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACC3 35
  • 95.98 (n)
  • 94.46 (a)
TACC3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacc3 35
  • 73.58 (n)
  • 69.39 (a)
dog
(Canis familiaris)
Mammalia TACC3 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC3 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC3 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC3 35
  • 54.61 (n)
  • 47.59 (a)
TACC3 36
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc3 35
  • 57.74 (n)
  • 51.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia masking 35
zebrafish
(Danio rerio)
Actinopterygii sbcb500 35
tacc3 35
  • 50.98 (n)
  • 42.59 (a)
tacc3 36
  • 22 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5601 35
fruit fly
(Drosophila melanogaster)
Insecta tacc 36
  • 9 (a)
OneToMany
Species with no ortholog for TACC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC3 Gene

ENSEMBL:
Gene Tree for TACC3 (if available)
TreeFam:
Gene Tree for TACC3 (if available)

Paralogs for TACC3 Gene

Paralogs for TACC3 Gene

(2) SIMAP similar genes for TACC3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TACC3 Gene

genes like me logo Genes that share paralogs with TACC3: view

Variants for TACC3 Gene

Sequence variations from dbSNP and Humsavar for TACC3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs34205238 - 1,727,829(-) AGACT(C/T)GCTGG intron-variant, reference, missense
rs17132047 - 1,728,226(+) GGGCT(A/G)CCCTG intron-variant, reference, missense
rs1063743 - 1,728,261(+) CAGAT(A/G)GCACT intron-variant, reference, missense
rs17680881 - 1,731,251(+) GCAGG(A/G)GCAGC reference, missense
rs8389 -- 1,745,117(+) TTTTT(A/T)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TACC3 Gene

Variant ID Type Subtype PubMed ID
nsv878328 CNV Loss 21882294
nsv878347 CNV Loss 21882294
dgv5408n71 CNV Loss 21882294
nsv822437 CNV Loss 20364138
nsv470000 CNV Loss 18288195
dgv5414n71 CNV Loss 21882294
dgv1565e1 CNV Complex 17122850
nsv428434 CNV Gain 18775914
nsv508989 CNV Insertion 20534489
nsv878392 CNV Loss 21882294
nsv878393 CNV Loss 21882294
dgv5415n71 CNV Loss 21882294
dgv5416n71 CNV Loss 21882294
nsv290066 CNV Insertion 16902084
dgv5417n71 CNV Loss 21882294
nsv878400 CNV Loss 21882294

Variation tolerance for TACC3 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACC3 Gene

HapMap Linkage Disequilibrium report
TACC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC3 Gene

Disorders for TACC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TACC3 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
urinary bladder cancer
  • bladder cancer
- elite association - COSMIC cancer census association via MalaCards
Search TACC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACC3

Genetic Association Database (GAD)
TACC3
Human Genome Epidemiology (HuGE) Navigator
TACC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACC3
genes like me logo Genes that share disorders with TACC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC3 Gene

Publications for TACC3 Gene

  1. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PMID: 17675670) Schneider L. … Piekorz R.P. (J. Biol. Chem. 2007) 2 3 23 67
  2. Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. (PMID: 19148534) Yim E.K. … Park J.S. (Oncol. Rep. 2009) 3 23
  3. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. (PMID: 17060449) Mori D. … Hirotsune S. (Mol. Cell. Biol. 2007) 3 23
  4. TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. (PMID: 16410616) Angrisano T. … Chiariotti L. (Nucleic Acids Res. 2006) 3 23
  5. Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. (PMID: 14602875) Tien A.-C. … Huang C.-Y.F. (Mol. Cell. Proteomics 2004) 3 23

Products for TACC3 Gene

Sources for TACC3 Gene

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