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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TACC3 Gene

protein-coding   GIFtS: 61
GCID: GC04P001690

transforming, acidic coiled-coil containing protein 3
 Explore 17 diseases affiliated with
TACC3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TACC3    

Aliases
for TACC3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transforming, Acidic Coiled-Coil Containing Protein 31 2
ERIC11 2 3
ERIC-12 3
Transforming Acidic Coiled-Coil-Containing Protein 32

External Ids:    HGNC: 115241   Entrez Gene: 104602   Ensembl: ENSG000000138107   OMIM: 6053035   UniProtKB: Q9Y6A53   

Export aliases for TACC3 gene to outside databases

Previous GC identifers: GC04P001715 GC04P001684


Summaries
for TACC3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TACC3:
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor
spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in
growth a differentiation of certain cancer cells. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer

Gene Wiki entry for TACC3


Genomic Views
for TACC3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TACC3 gene promoter:
         p53   HTF   Nkx2-5   NF-E2   NF-E2 p45   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TACC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TACC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TACC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

TACC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACC3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P001690:  view genomic region     (about GC identifiers)

Start:
 1,723,227 bp from pter      End:
 1,746,898 bp from pter
Size:
 23,672 bases      Orientation:
 plus strand

Proteins
for TACC3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5 (See protein sequence)
Recommended Name: Transforming acidic coiled-coil-containing protein 3  
Size: 838 amino acids; 90360 Da
Subunit: Interacts with microtubules. Interacts with CCDC100/CEP120. The coiled coil C-terminus region interacts with
AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q3KQS5 Q9UMQ1

Explore the universe of human proteins at neXtProt for TACC3: NX_Q9Y6A5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6A5

    • TACC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006333.1  
    ENSEMBL proteins: 
     ENSP00000419210   ENSP00000418727   ENSP00000326550   ENSP00000418095   ENSP00000415914  
     ENSP00000420838  

    Human Recombinant Protein Products: 
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    Novus Biologicals TACC3 Protein
    Novus Biologicals TACC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TACC3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--


    TACC3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TACC3

    Protein Domains /
    Families
    for TACC3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TACC3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007707 TACC

    Graphical View of Domain Structure for InterPro Entry Q9Y6A5

    ProtoNet protein and cluster: Q9Y6A5

    1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing

    UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
    Similarity: Belongs to the TACC family


    Function
    for TACC3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TACC3_HUMAN, Q9Y6A5
    Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
    processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
    similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer
    Induction: Up-regulated in various cancer cell lines

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TACC3:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmid: TACC3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACC3 (see all 7)
    OriGene shRNA RFP: TACC3
    OriGene siRNA: TACC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TACC3

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACC3 

    Cell Line
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    Search LifeMap BioReagents cell lines for TACC3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019904protein domain specific binding IEA--


    TACC3 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for TACC3:
     Cell cycle / mitosis defect  Decreased G3BP1 protein expres  Decreased TP53 protein express  Decreased viability of wild-ty 
     Decreased viability with pacli  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for TACC3: Tacc3tm1.2Tno Tacc3tm1Jni
         13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tacc3):
     behavior/neurological  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  immune system  limbs/digits/tail  liver/biliary system  mortality/aging 
     normal  skeleton  tumorigenesis 

    TACC3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TACC3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    2Aurora A signaling
    		Aurora A signaling1.00
    3RNA transport
    		RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TACC3
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for TACC3 
        Aurora A signaling


    1         Kegg Pathway  (Kegg details for TACC3):
        RNA transport


    TACC3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TACC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for TACC3 (Q9Y6A52, 3 ENSP000003265504) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKAP5Q140082, 3, ENSP000003465664MINT-8145000 MINT-8144928 MINT-8144977 MINT-8145261 MINT-8145016 MINT-8145273 I2D: score=3 STRING: ENSP00000346566
    CLTAP094962, 3, ENSP000002422854MINT-8144928 MINT-8145261 MINT-8151296 MINT-8145273 I2D: score=1 STRING: ENSP00000242285
    KAT2AQ928303, ENSP000002259164I2D: score=2 STRING: ENSP00000225916
    AKAP9Q999963, ENSP000003485734I2D: score=1 STRING: ENSP00000348573
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006950response to stress IEA--
    GO:0008283cell proliferation ----
    GO:0021987cerebral cortex development IEA--
    GO:0022008neurogenesis IEA--


    TACC3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TACC3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TACC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TACC3
    1 Novoseek chemical compound relationship for TACC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 9.08 2 17545617 (1)

    Search CenterWatch for drugs/clinical trials and news about TACC3 

    Transcripts
    for TACC3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TACC3 gene: 
    NM_006342.2  

    Unigene Cluster for TACC3:

    Transforming, acidic coiled-coil containing protein 3
    Hs.104019  [show with all ESTs]
    Unigene Representative Sequence: NM_006342
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485989 ENST00000484651(uc010ibz.3) ENST00000467746 ENST00000313288(uc003gdo.3 uc003gdp.3)
    ENST00000493975 ENST00000458173 ENST00000470136 ENST00000466077 ENST00000470808
    ENST00000484264

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TACC3:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmid: TACC3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACC3 (see all 7)
    OriGene shRNA RFP: TACC3
    OriGene siRNA: TACC3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TACC3
    Clone
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    GenScript: all cDNA clones in your preferred vector: TACC3 (NM_006342)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TACC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACC3

    Additional cDNA sequence: 

    AF093543.1 AF479620.1 AJ243997.1 AK225631.1 AK302463.1 AK304579.1 AK310660.1 BC106071.1 
    BC111771.1 U38441.1 

    10 DOTS entries:

    DT.445189  DT.92439981  DT.92439982  DT.95351311  DT.97824856  DT.100668137  DT.95351308  DT.100700633 
    DT.86848730  DT.97812662 

    24/258 AceView cDNA sequences (see all 258):

    AA357042 BG677631 AL134877 CR621870 BU167788 BE552327 CR624101 AA649020 
    AA355718 BU528229 BF797521 AI460042 AI090599 BQ230086 CR606211 CR591833 
    BF513039 BI869396 BQ932141 BF875023 AW079497 AW510471 CK905196 BM710733 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TACC3 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                    -                                                     -     -     -                 -                 -                           
    SP2:                                                                                -     -                 -                 -                           
    SP3:                                                                                                                                                      
    SP4:              -     -                                                                                                                                 
    SP5:                                                                                                        -                                             


    ECgene alternative splicing isoforms for TACC3

    Expression
    for TACC3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TACC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCAATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TACC3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See TACC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TACC3

    SOURCE GeneReport for Unigene cluster: Hs.104019
        SABiosciences Custom PCR Arrays for TACC3
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    In Situ
    Assay Products:     
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    Orthologs
    for TACC3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TACC3 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TACC31 transforming, acidic coiled-coil containing protein more 54.89(n)
    48.16(a)    		   422899  NM_001004429.2  NP_001004429.2 
    African clawed frog
    (Xenopus laevis)    		 Amphibia masking2 CPEB-associated factor Maskin 75.78(n)    AF200212.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb5002 Danio rerio transforming acidic coiled coil 3 protein more 74.93(n)    AY170618.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta tacc6
    		 transforming acidic coiled-coil protein
    		 9(a)
    		 possible ortholog
    		 3R(559376-574778)


    ENSEMBL Gene Tree for TACC3 (if available)
    TreeFam Gene Tree for TACC3 (if available) 

    Paralogs
    for TACC3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TACC3 gene
    TACC22  TACC12  
    2 SIMAP similar genes for TACC3 using alignment to 7 protein entries:     TACC3_HUMAN (see all proteins):
    ERIC-1s    TACC2

    TACC3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TACC3
    PGOHUM00000242640 PGOHUM00000234848


    Genomic Variants
    for TACC3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TACC3
         2 CNVs: 30192 3476
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TACC3
    DNA2.0 Custom Variant and Variant Library Synthesis for TACC3

    Disorders / Diseases
    for TACC3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TACC3 for disorders           About GeneDecksing

    OMIM gene information: 605303   
    OMIM disorders: 109800  
    17 diseases for TACC3:    About MalaCards
    urinary bladder cancer    bladder cancer susceptibility    multiple myeloma    ovarian cancer
    myeloma    cervical carcinoma    hematopoiesis    cervicitis
    thyroid cancer    pancreatic cancer    thyroiditis    lung cancer
    breast cancer    pancreatitis    glioblastoma    cerebritis
    carcinoma

    3 Novoseek disease relationships for TACC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 20.9 6 15918899 (4)
    cancer 9.64 9 10366448 (2), 17545617 (1), 17675670 (1), 15918899 (1)
    tumors 2.02 18 15918899 (4), 16930330 (3), 17545617 (2), 16773180 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: TACC3 (4 documents)

    Export disorders for TACC3 gene to outside databases

    Publications
    for TACC3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TACC3 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with TACC3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. (PubMed id 17675670)1, 3, 9 Schneider L....Piekorz R.P. (2007)
    2. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. (PubMed id 10366448)1, 2, 9 Still I.H.... Cowell J.K. (1999)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2 Gangisetty O.... Still I.H. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization and localization of expression of an erythropoietin- induced gene, ERIC-1/TACC3, identified in erythroid precursor cells. (PubMed id 11298601)1, 2 McKeveney P.J.... Maxwell A.P. (2001)
    7. TACC3 expression is tightly regulated during early differentiation. (PubMed id 12711550)1, 9 Sadek C.M....Gustafsson J.A. (2003)
    8. Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. (PubMed id 19148534)1, 9 Yim E.K....Park J.S. (2009)
    9. The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. (PubMed id 11847113)1, 9 Piekorz R.P....Ihle J.N. (2002)
    10. TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. (PubMed id 16410616)1, 9 Angrisano T....Chiariotti L. (2006)

    External Searches for TACC3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TACC3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10460 HGNC: 11524 AceView: TACC3 Ensembl:ENSG00000013810 euGenes: HUgn10460
    ECgene: TACC3 Kegg: 10460 H-InvDB: TACC3

    Other Databases showing TACC3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TACC3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TACC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TACC3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TACC3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TACC3 gene:
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