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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TACC2 Gene

protein-coding GIFtS: 56
GCID: GC10P123738

transforming, acidic coiled-coil containing protein 2

Explore 9 diseases affiliated with
TACC2 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transforming, Acidic Coiled-Coil Containing Protein 2¹ ²		Anti-Zuai-1³
AZU-1¹ ² ³		EC 2.4.2.10⁸
ECTACC²		EC 4.3.2.1⁸
Anti Zuai-1²		EC 6.3.5.2⁸
Transforming Acidic Coiled-Coil-Containing Protein 2²

External Ids:	HGNC: 11523¹	Entrez Gene: 10579²	Ensembl: ENSG00000138162⁷	OMIM: 605302⁵	UniProtKB: O95359³

Export aliases for TACC2 gene to outside databases

Previous GC identifers: GC10P122942 GC10P123166 GC10P123879 GC10P123446 GC10P123474 GC10P117379

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TACC2:

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins

that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle.

This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by

erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the

processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By

similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May

represent a tumor progression marker

Gene Wiki entry for TACC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TACC2 gene promoter:
E2F-3a E2F-4 E2F-5 Pax-6 FOXD1 AP-4 E2F-2 PPAR-alpha E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TACC2 promoter sequence

Search SABiosciences Chromatin IP Primers for TACC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TACC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26

TACC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACC2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P123738: view genomic region (about GC identifiers)

Start:	123,748,689 bp from pter	End:	124,014,060 bp from pter
Size:	265,372 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359 (See protein sequence)

Recommended Name: Transforming acidic coiled-coil-containing protein 2

Size: 2948 amino acids; 309427 Da

Subunit: Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and

PCAF

Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome

Developmental stage: Expressed in fetal brain, lung, liver and kidney

Sequence caution: Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAF63433.1;

Type=Erroneous initiation;

Secondary accessions: Q4VXL0 Q4VXL3 Q4VXL6 Q4VXL7 Q5U5T7 Q86WG6 Q86WG7 Q8TCK9 Q9BVQ1 Q9NZ41 Q9NZR5

Alternative splicing: 6 isoforms: O95359-4 O95359-1 O95359-2 O95359-3 O95359-5 O95359-6 (Contains a phosphothreonine at position 2625)

Explore the universe of human proteins at neXtProt for TACC2: NX_O95359

Post-translational modifications:

Phosphorylated by TTK; which is required for localization in centrosome¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95359

3 DME Specific Peptides for TACC2 (O95359)

ASTPSCP

DAYSTGSS

LASGLPSP

TACC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_008928.1 NP_996742.1 NP_996743.1 NP_996744.2

ENSEMBL proteins:

ENSP00000358001 ENSP00000425062 ENSP00000424467 ENSP00000427618 ENSP00000423069

ENSP00000357997 ENSP00000357996 ENSP00000353763 ENSP00000357995 ENSP00000422815

ENSP00000260733 ENSP00000420967 ENSP00000421702 ENSP00000426303 ENSP00000422725

ENSP00000425525 ENSP00000423764 ENSP00000334280 ENSP00000350701 ENSP00000395048

Human Recombinant Protein Products for TACC2:

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	Novus Biologicals TACC2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TACC2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005815	microtubule organizing center	IEA	--

TACC2 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for TACC2

Assay Products for TACC2:

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	Uscn ELISAs and CLIAs for TACC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TACC2 for domains About GeneDecksing

1 InterPro domain/family:

IPR007707 TACC

Graphical View of Domain Structure for InterPro Entry O95359

ProtoNet protein and cluster: O95359

1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Similarity: Belongs to the TACC family

Similarity: Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TACC2_HUMAN, O95359

Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the

processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By

similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May

represent a tumor progression marker

Enzyme Numbers (IUBMB): EC 4.3.2.1² EC 2.4.2.10² EC 6.3.5.2²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019904	protein domain specific binding	IEA	--
GO:0035257	nuclear hormone receptor binding	IDA	15207008

TACC2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for TACC2:

Decreased G3BP1 protein expres

Increased HPV18 LCR reporter a

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tacc2):

normal

tumorigenesis

TACC2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tacc2^tm1Jni for TACC2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TACC2

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TACC2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACC2
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TACC2 (see all 28):
		hsa-miR-3910 hsa-miR-217 hsa-miR-125a-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-1278 hsa-miR-3129-5p hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: TACC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACC2 (see all 7) OriGene shRNA RFP: TACC2 OriGene siRNA: TACC2
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TACC2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TACC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/14 Interacting proteins for TACC2 (O95359^{2, 3} ENSP00000334280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TTK	P33981²^,³, ENSP00000230510⁴	MINT-50599 MINT-50600 I2D: score=1 STRING: ENSP00000230510
HMG20B	Q9P0W2²^,³, ENSP00000328269⁴	MINT-65670 I2D: score=5 STRING: ENSP00000328269
KAT2A	Q92830³, ENSP00000225916⁴	I2D: score=2 STRING: ENSP00000225916
SMARCB1	Q12824³, ENSP00000263121⁴	I2D: score=2 STRING: ENSP00000263121
AURKC	Q9UQB9³, ENSP00000302898⁴	I2D: score=1 STRING: ENSP00000302898

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	--	--
GO:0008283	cell proliferation	--	--
GO:0021987	cerebral cortex development	IEA	--
GO:0022008	neurogenesis	IEA	--
GO:0022027	interkinetic nuclear migration	IEA	--

TACC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TACC2
Search CenterWatch for drugs/clinical trials and news about TACC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TACC2 gene (4 alternative transcripts):

NM_006997.2 NM_206860.1 NM_206861.1 NM_206862.2

Unigene Clusters for TACC2:

Transforming, acidic coiled-coil containing protein 2

Hs.501252 [show with all ESTs], Hs.713875 [show with all ESTs]

Unigene Representative Sequences: AF528099, BC029124

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000492689 ENST00000369005(uc001lfv.3 uc009xzx.3 uc010qtv.2)

ENST00000513429(uc001lfw.3) ENST00000515273 ENST00000515603 ENST00000498721

ENST00000474014 ENST00000489754 ENST00000491540 ENST00000493951 ENST00000369001(uc001lfx.3)

ENST00000492237 ENST00000369000(uc001lfy.3) ENST00000360561(uc001lga.3 uc009xzy.3)

ENST00000368999(uc001lfz.3) ENST00000369004 ENST00000260733 ENST00000514539(uc010qtw.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TACC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TACC2
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TACC2 (see all 28):
		hsa-miR-3910 hsa-miR-217 hsa-miR-125a-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-1278 hsa-miR-3129-5p hsa-miR-25

		SwitchGear 3'UTR luciferase reporter plasmid: TACC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TACC2 (see all 7) OriGene shRNA RFP: TACC2 OriGene siRNA: TACC2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TACC2

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Additional cDNA sequence: BC029124.1

24/29 DOTS entries (see all 29):

DT.92436580 DT.91785837 DT.100821624 DT.102835591 DT.100821621 DT.97787283 DT.117550 DT.91665866

DT.121239147 DT.121239228 DT.95188118 DT.100741568 DT.121239237 DT.100000873 DT.91661197 DT.92032483

DT.95115888 DT.95319329 DT.101975725 DT.121239160 DT.97843751 DT.97859639 DT.121239208 DT.121239270

24/277 AceView cDNA sequences (see all 277):

AA935720 CF528324 AI679077 NM_206860 F10797 F13192 AI299389 AI539158

CB216286 BQ011915 CA447782 AW850463 AI564711 AF095791 AK056743 AA132922

BG696788 BU689821 F01663 CF528952 AL713712 BC039311 BU622761 CA417838

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 (see all 18) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	·	14d	·	14e	·	14f	·	14g	^
SP1:											-		-		-		-		-		-						-		-		-						-		-
SP2:					-		-		-		-		-		-		-		-		-				-		-		-		-						-		-
SP3:																															-						-		-
SP4:																									-		-		-		-						-		-
SP5:																															-						-		-

ExUns:	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b
SP1:					-																								-				-
SP2:					-																								-				-
SP3:					-																								-				-
SP4:					-		-														-		-						-				-
SP5:					-																		-						-				-

ECgene alternative splicing isoforms for TACC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TACC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTACATTC

About this image

TACC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TACC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TACC2

SOURCE GeneReport for Unigene clusters: Hs.501252 Hs.713875

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea

SABiosciences Custom PCR Arrays for TACC2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TACC2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tacc2^{1 , 5}	transforming, acidic coiled-coil containing protein more^{1, 5}	74.51(n)¹ 63.52(a)¹		7 (73.19 cM)⁵ 57752¹ NM_001004468.2¹ NP_001004468.1¹ 130577484⁵
chicken (Gallus gallus)	Aves	TACC2¹	transforming, acidic coiled-coil containing protein more	74.11(n) 74.88(a)		423939 XM_421798.3 XP_421798.3
lizard (Anolis carolinensis)	Reptilia	TACC2⁶	--	69(a)	1 ↔ 1	3(64118383-64179954)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9694²	Xenopus laevis transcribed sequence with weak similarity more	85.62(n)		BJ084975.1
zebrafish (Danio rerio)	Actinopterygii	BQ169353.1²	--	77.8(n)		321181 BQ169353.1
fruit fly (Drosophila melanogaster)	Insecta	tacc⁶	transforming acidic coiled-coil protein	12(a)	possible ortholog	3R(559376-574778)

ENSEMBL Gene Tree for TACC2 (if available)
TreeFam Gene Tree for TACC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TACC2 gene

TACC3² TACC1²

2 SIMAP similar genes for TACC2 using alignment to 15 protein entries: TACC2_HUMAN (see all proteins):

TACC1 TACC3

TACC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58585570^1,2	F	--	117378034(+)	`CAACAG/AGTCCT`	2	--	us2k¹		1	WA	118
rs112776260^1,2		--	117378499(+)	`AGATAA/G/TAGTCT`	2	--	us2k¹		1	CSA	2
rs7071793^1,2	C,F,H	--	117379143(+)	`aggccG/Agctcc`	2	--	us2k¹		5	NS EA WA	516
rs56264039^1,2	C,F	--	117379488(+)	`GTGCAC/TTGGGA`	2	--	ut5¹		2	NS WA	80
rs77140283^1,2	C,F	--	117380433(+)	`GCTAAC/TGCAAT`	2	--	int¹		1	WA	118
rs12777489^1,2	C,F	--	117381042(+)	`ggactC/Tgctgt`	2	--	int¹		4	NA	126
rs113330134^1,2		--	117381850(+)	`ATGGTG/AGCACC`	2	--	int¹		1	CSA	2
rs17102820^1,2	C,F,H	--	117382421(+)	`CAAAAG/ATGAGA`	2	--	int¹		11	NA NS EA WA CSA	804
rs112788988^1,2		--	117382430(+)	`GAAGTG/AGTAGA`	2	--	int¹		1	CSA	2
rs112508891^1,2	F	--	117382559(+)	`GAGCCG/AAAAAA`	2	--	int¹		2	CSA	4

HapMap Linkage Disequilibrium report for TACC2 (123748689 - 123998689 bp, first 250kb of TACC2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TACC2
3 CNVs: 48441 48440 47848
1 Indel: 44675

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TACC2 for disorders           About GeneDecksing

OMIM gene information: 605302    OMIM disorders: --

9 diseases for TACC2:    About MalaCards

fanconi's anemia multiple myeloma breast cancer anemia

myeloma alzheimer's disease cerebritis thyroiditis

prostatitis

3 Novoseek disease relationships for TACC2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	38	6	20335520 (4), 15226440 (1)
cancer	12.6	2	15226440 (1), 20335520 (1)
tumors	0	5	15226440 (4), 14603251 (1)

Human Genome Epidemiology (HuGE) Navigator: TACC2 (4 documents)

Export disorders for TACC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TACC2 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with TACC2)

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The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)^{1, 2, 3} Gangisetty O.... Still I.H. (2004)
TTK kinase is essential for the centrosomal localization of TACC2. (PubMed id 15304323)^{1, 2, 9} Dou Z.... Yao X. (2004)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PubMed id 12620397)^{1, 2} Lauffart B.... Still I.H. (2003)
Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. (PubMed id 11161455)^{1, 2} Pu J.J.... Banerjee D. (2001)
AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. (PubMed id 10749935)^{1, 2} Chen H.-M....Bissell M.J. (2000)
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PubMed id 11121038)^{1, 2} Gergely F....Raff J.W. (2000)
Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic rele vance. (PubMed id 20335520)^{1, 9} Cheng S....Jiang W.G. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10579	HGNC: 11523	AceView: TACC2	Ensembl:ENSG00000138162	euGenes: HUgn10579
ECgene: TACC2	H-InvDB: TACC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TACC2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TACC2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TACC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TACC2 gene:
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GeneCards and IP:
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transforming, acidic coiled-coil containing protein 2

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transforming, acidic coiled-coil containing protein 2

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