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Aliases for TACC2 Gene

Aliases for TACC2 Gene

  • Transforming, Acidic Coiled-Coil Containing Protein 2 2 3
  • AZU-1 3 4
  • Transforming Acidic Coiled-Coil-Containing Protein 2 3
  • Anti Zuai-1 3
  • Anti-Zuai-1 4
  • EC 2.4.2.10 63
  • EC 4.3.2.1 63
  • EC 6.3.5.2 63
  • ECTACC 3

External Ids for TACC2 Gene

Summaries for TACC2 Gene

Entrez Gene Summary for TACC2 Gene

  • Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACC2 Gene

TACC2 (Transforming, Acidic Coiled-Coil Containing Protein 2) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and nuclear hormone receptor binding. An important paralog of this gene is TACC1.

UniProtKB/Swiss-Prot for TACC2 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Gene Wiki entry for TACC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC2 Gene

Genomics for TACC2 Gene

Genomic Location for TACC2 Gene

Start:
121,989,174 bp from pter
End:
122,254,545 bp from pter
Size:
265,372 bases
Orientation:
Plus strand

Genomic View for TACC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TACC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC2 Gene

Regulatory Elements for TACC2 Gene

Proteins for TACC2 Gene

  • Protein details for TACC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95359-TACC2_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 2
    Protein Accession:
    O95359
    Secondary Accessions:
    • Q4VXL0
    • Q4VXL3
    • Q4VXL6
    • Q4VXL7
    • Q5U5T7
    • Q86WG6
    • Q86WG7
    • Q8TCK9
    • Q9BVQ1
    • Q9NZ41
    • Q9NZR5

    Protein attributes for TACC2 Gene

    Size:
    2948 amino acids
    Molecular mass:
    309427 Da
    Quaternary structure:
    • Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.
    SequenceCaution:
    • Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF63433.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TACC2 Gene

neXtProt entry for TACC2 Gene

Proteomics data for TACC2 Gene at MOPED

Selected DME Specific Peptides for TACC2 Gene

Post-translational modifications for TACC2 Gene

  • Phosphorylated by TTK; which is required for localization in centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for TACC2 Gene

Protein Domains for TACC2 Gene

Graphical View of Domain Structure for InterPro Entry

O95359

UniProtKB/Swiss-Prot:

TACC2_HUMAN
Domain:
  • Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.:
    • O95359
Family:
  • Belongs to the TACC family.:
    • O95359
genes like me logo Genes that share domains with TACC2: view

No data available for Gene Families for TACC2 Gene

Function for TACC2 Gene

Molecular function for TACC2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Enzyme Numbers (IUBMB) for TACC2 Gene

Gene Ontology (GO) - Molecular Function for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019904 protein domain specific binding IEA --
GO:0035257 nuclear hormone receptor binding IDA 15207008
genes like me logo Genes that share ontologies with TACC2: view
genes like me logo Genes that share phenotypes with TACC2: view

Animal Models for TACC2 Gene

MGI Knock Outs for TACC2:

miRNA for TACC2 Gene

miRTarBase miRNAs that target TACC2

No data available for Transcription Factor Targeting and HOMER Transcription for TACC2 Gene

Localization for TACC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC2 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACC2 Gene COMPARTMENTS Subcellular localization image for TACC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with TACC2: view

Pathways for TACC2 Gene

SuperPathways for TACC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0008283 cell proliferation IBA --
GO:0021987 cerebral cortex development IBA --
GO:0022008 neurogenesis IEA --
GO:0022027 interkinetic nuclear migration IEA --
genes like me logo Genes that share ontologies with TACC2: view

No data available for Pathways by source for TACC2 Gene

Transcripts for TACC2 Gene

Unigene Clusters for TACC2 Gene

Transforming, acidic coiled-coil containing protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for TACC2 Gene

GeneLoc Exon Structure for
TACC2
ECgene alternative splicing isoforms for
TACC2

Expression for TACC2 Gene

mRNA expression in normal human tissues for TACC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC2 Gene

This gene is overexpressed in Muscle - Skeletal (9.9) and Heart - Left Ventricle (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TACC2 Gene

SOURCE GeneReport for Unigene cluster for TACC2 Gene Hs.501252

mRNA Expression by UniProt/SwissProt for TACC2 Gene

O95359-TACC2_HUMAN
Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.
genes like me logo Genes that share expressions with TACC2: view

Orthologs for TACC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC2 35
  • 99.24 (n)
  • 99.09 (a)
TACC2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TACC2 35
  • 78.41 (n)
  • 68.18 (a)
TACC2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACC2 35
  • 78.95 (n)
  • 69.1 (a)
TACC2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacc2 35
  • 74.58 (n)
  • 63.47 (a)
Tacc2 16
Tacc2 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC2 36
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacc2 35
  • 73.63 (n)
  • 62.2 (a)
chicken
(Gallus gallus)
Aves TACC2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC2 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9694 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc2 35
  • 60.66 (n)
  • 58.58 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
TACC2 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tacc 36
  • 12 (a)
OneToMany
Species with no ortholog for TACC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC2 Gene

ENSEMBL:
Gene Tree for TACC2 (if available)
TreeFam:
Gene Tree for TACC2 (if available)

Paralogs for TACC2 Gene

Paralogs for TACC2 Gene

genes like me logo Genes that share paralogs with TACC2: view

Variants for TACC2 Gene

Sequence variations from dbSNP and Humsavar for TACC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15151 -- 122,254,422(+) GGACT(C/T)TTGCC utr-variant-3-prime
rs736456 -- 122,253,032(+) GATGA(A/G)TGACA intron-variant
rs736457 -- 122,253,047(+) GAGTT(C/G)TAACC intron-variant
rs746070 -- 122,241,690(-) AGGTA(C/T)TGAGA intron-variant
rs754482 -- 122,251,923(+) GACCT(A/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACC2 Gene

Variant ID Type Subtype PubMed ID
nsv896051 CNV Loss 21882294
nsv832009 CNV Loss 17160897
esv34167 CNV Loss 18971310
nsv519434 CNV Loss 19592680
nsv526940 CNV Loss 19592680
nsv896054 CNV Loss 21882294
nsv896055 CNV Loss 21882294
dgv829n71 CNV Loss 21882294
nsv896057 CNV Loss 21882294
dgv830n71 CNV Loss 21882294
dgv831n71 CNV Loss 21882294
nsv467468 CNV Loss 19166990
nsv521165 CNV Loss 19592680
esv2666599 CNV Deletion 23128226
esv1958270 CNV Deletion 18987734
esv2742073 CNV Deletion 23290073
esv2742084 CNV Deletion 23290073
nsv825593 CNV Gain 20364138
esv275180 CNV Gain+Loss 21479260

Relevant External Links for TACC2 Gene

HapMap Linkage Disequilibrium report
TACC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC2 Gene

Disorders for TACC2 Gene

(3) Novoseek inferred disease relationships for TACC2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 38 5
cancer 12.6 2
tumors 0 5

Relevant External Links for TACC2

Genetic Association Database (GAD)
TACC2
Human Genome Epidemiology (HuGE) Navigator
TACC2
genes like me logo Genes that share disorders with TACC2: view

No data available for UniProtKB/Swiss-Prot for TACC2 Gene

Publications for TACC2 Gene

  1. TTK kinase is essential for the centrosomal localization of TACC2. (PMID: 15304323) Dou Z. … Yao X. (FEBS Lett. 2004) 3 4 23
  2. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PMID: 14767476) Gangisetty O. … Still I.H. (Oncogene 2004) 2 3 4
  3. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PMID: 12620397) Lauffart B. … Still I.H. (Genomics 2003) 3 4
  4. AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. (PMID: 10749935) Chen H.-M. … Bissell M.J. (Mol. Biol. Cell 2000) 3 4
  5. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PMID: 11121038) Gergely F. … Raff J.W. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for TACC2 Gene

Sources for TACC2 Gene

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