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TACC2 Gene

protein-coding GIFtS: 59

GC10P123738

transforming, acidic coiled-coil containing protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AZU-1 ^¹, ², ³
ECTACC ^²
OTTHUMP00000020645 ^²
OTTHUMP00000035135 ^²

Descriptions
Anti Zuai-1 ^², ³
transforming, acidic coiled-coil containing protein 2 ^²

External Ids
HGNC: 11523¹
Entrez Gene: 10579²
UniProtKB: O95359³
Ensembl: ENSG00000138162⁷

Search outside databases for aliases for TACC2 gene

Previous GC identifers: GC10P122942 GC10P123166 GC10P123879 GC10P123446 GC10P123474

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TACC2:

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and

microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that

concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region

associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought

to affect the progression of breast tumors. Several transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.

Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM)

of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May

act as a tumor suppressor protein. May represent a tumor progression marker

Gene Wiki entry for TACC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TACC2 gene

Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26

TACC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P123738: (about GC identifiers)

Start:	123,738,679 bp from pter
End:	124,004,049 bp from pter
Size:	265,371 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359 (See protein sequence)

Recommended Name: Transforming acidic coiled-coil-containing protein 2

Size: 2948 amino acids; 309427 Da

Subunit: Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with

YEATS4, GCN5L2 and PCAF

Subcellular location: Cytoplasm. Nucleus. Centrosome

Developmental stage: Expressed in fetal brain, lung, liver and kidney

Secondary accessions: Q4VXL0 Q4VXL3 Q4VXL6 Q4VXL7 Q5U5T7 Q86WG6 Q86WG7 Q8TCK9 Q9BVQ1 Q9NZ41 Q9NZR5

Alternative splicing: 6 isoforms: O95359-4 O95359-1 O95359-2 O95359-3 O95359-5 O95359-6 (Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

Phosphorylated by TTK; which is required for localization in centrosome¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_008928.1 NP_996742.1 NP_996743.1 NP_996744.2

ENSEMBL proteins:

ENSP00000334280 ENSP00000350701 ENSP00000358001 ENSP00000358000 ENSP00000343715 ENSP00000260733

ENSP00000353763 ENSP00000357995 ENSP00000357993 ENSP00000357997 ENSP00000357996

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TACC2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IEA	--

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Antibodies for TACC2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TACC2
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TACC2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for TACC2

Assays for TACC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O95359

ProtoNet protein and cluster: O95359

1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Similarity: Belongs to the TACC family

Similarity: Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACC2)
		Millipore RNAi Products for the Analysis of TACC2 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_006997

Applied Biosystems Silencer® siRNAs for TACC2

Sigma-Aldrich siRNA and siRNA Panels for TACC2

Sigma-Aldrich shRNA for TACC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_006997
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_006997
untagged cDNA clones in CMV expression vector (see all 5): NM_006997

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_206862

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359

Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.

Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM)

of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May

act as a tumor suppressor protein. May represent a tumor progression marker

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tacc2):

normal

tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IDA	15207008
GO:0035257	nuclear hormone receptor binding	IDA	15207008

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TACC2

5 Interacting proteins for TACC2 (ENSP00000358001³ O95359²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TTK	P33981²	STRING (score=.824) MINT-50599 MINT-50600
HMG20B	Q9P0W2²	MINT-65670
YEATS4	ENSP00000247843³	STRING (score=.878)
CKAP5	ENSP00000346566³	STRING (score=.848)
--	ENSP00000325014³	STRING (score=.933)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TACC2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACC2)
		Millipore RNAi Products for the Analysis of TACC2 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_006997

Sigma-Aldrich siRNA and siRNA Panels for TACC2

Sigma-Aldrich shRNA for TACC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006997 NM_206860 NM_206861 NM_206862

REFSEQ mRNAs for TACC2 gene (4 alternative transcripts):

NM_006997.2 NM_206860.1 NM_206861.1 NM_206862.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006997 NM_206860 NM_206861 NM_206862

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_006997
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_006997
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_006997

Additional cDNA sequence:

BC029124.1 XM_001726456.1

24/29 DOTS entries (see all 29 ):

DT.92436580 DT.91785837 DT.100821624 DT.102835591 DT.100821621 DT.97787283 DT.117550 DT.91665866

DT.121239147 DT.121239228 DT.95188118 DT.100741568 DT.121239237 DT.92032483 DT.100000873 DT.91661197

DT.95115888 DT.95319329 DT.101975725 DT.121239160 DT.97843751 DT.97859639 DT.121239208 DT.121239270

24/277 AceView cDNA sequences (see all 277 ):

BC000999 CB216286 AI564711 CA417838 AW295050 AI299389 AK056743 Z44440

BX282179 AF095791 AI801508 H90662 CA447782 H91589 CF528324 BQ631276

NM_206862 AI214322 AL713712 AA935720 AA132922 AI698058 Z42121 BM672642

highest scoring ESTs for TACC2:

AF095791 AA176435 AA176449 AA506062 AA534776 AA593098 AA632939 AA635668 AA678366 AA704275

Unigene Clusters for TACC2:

Transforming, acidic coiled-coil containing protein 2

Hs.501252 [show with all ESTs], Hs.713875 [show with all ESTs]

Unigene Representative Sequences: AF528099, BC029124

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 (see all 18 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	·	14d	·	14e	·	14f	·	14g	^
SP1:											-		-		-		-		-		-						-		-		-						-		-
SP2:					-		-		-		-		-		-		-		-		-				-		-		-		-						-		-
SP3:																															-						-		-
SP4:																									-		-		-		-						-		-
SP5:																															-						-		-

ExUns:	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28a	·	28b	^	29a	·	29b	^	30	^	31a	·	31b
SP1:					-																								-				-
SP2:					-																								-				-
SP3:					-																								-				-
SP4:					-		-														-		-						-				-
SP5:					-																		-						-				-

About this scheme

ECgene alternative splicing isoforms for TACC2

11 Ensembl transcripts including schematic representations:

ENST00000334433 ENST00000358010 ENST00000369005 ENST00000369004 ENST00000340076 ENST00000260733

ENST00000360561 ENST00000368999 ENST00000368997 ENST00000369001 ENST00000369000

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TACC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TACC2

¹ / ² / ³

7 probe-sets matching TACC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61320_g_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.20	AL037611	0.20	0.12	0.17	2
38816_at²^{, 3}	U95-A	1	0.44	1.00	1.00	0.80	AF095791	1.00	1.00	1.00	1
202289_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006997	0.60	1.00	0.82	1
211382_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF220152	0.80	1.00	0.91	1
202289_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570546_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211382_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TACC2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTACATTC

SOURCE GeneReport for Unigene clusters: Hs.501252 Hs.713875
Expression variation in blood from EXPOLDB for TACC2
UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359
Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and
trachea

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for TACC2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TACC2¹	--	transforming, acidic coiled-coil containing protein more	79.1(n) 69.27(a)	477850 XM_535042.2 XP_535042.2
chimpanzee (Pan troglodytes)	TACC2¹	--	transforming, acidic coiled-coil containing protein more	98.74(n) 97.71(a)	742328 XM_001158836.1 XP_001158836.1
cow (Bos taurus)	TACC2¹	--	transforming, acidic coiled-coil containing protein more	78.69(n) 68.42(a)	533768 XM_613281.3 XP_613281.3
rat (Rattus norvegicus)	Tacc2¹	--	transforming, acidic coiled-coil containing protein more	73.76(n) 62.28(a)	309025 NM_001004415.1 NP_001004415.1
mouse (Mus musculus)	Tacc2^{1, 5}	7⁵	transforming, acidic coiled-coil containing protein more^{1, 5}	74.51(n)¹ 63.52(a)¹	57752¹ NM_001004468.2¹ NP_001004468.1¹ AA119899⁵ AB041546⁵ (see all 24)

About this table Species with no ortholog for TACC2

ENSEMBL Gene Tree for TACC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TACC2 gene

TACC3² TACC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/2022 NCBI SNPs in TACC2 are shown (see all 2022 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 587)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2295873^1,2	A,C,F,H	123960520(+)	`CGCTGT/CGGGGC`	4	A/V	mis¹		10	EA EU WA NA	2404
	rs11200385^1,2	A,C,F,H	123832513(+)	`CTGCCG/ATCCCC`	2	I/V	mis¹ int¹ ese³		11	NA EU EA WA	964
	rs10887063^1,2	A,C,F,H	123834493(+)	`AGCATC/TTCCAG`	2	L/F	mis¹ int¹ ese³		11	NA EU EA WA	972
	rs3763763^1,2	A,C,F,H	124003594(+)	`TGTTGA/CGTGCA`	4	--	ut3¹ ese³		17	MN EA NA EU WA	1658
	rs4752642^1,2	A,C,F,H	123836278(+)	`CCCTGG/ACCACA`	2	T/A	mis¹ int¹ ese³		8	EU EA WA	838
	rs2295874^1,2	C,F,H	123960559(+)	`GAGTGC/TAGAAG`	4	A/V	mis¹ ese³		9	EU EA WA NA	908
	rs2295879^1,2	C,F,H	123986966(+)	`GGACCG/ACTGAG`	4	T/A	mis¹ ese³		18	EA MN NA EU WA	3090
	rs12765679^1,2	C,F,H	123893123(+)	`CTGCAG/AAACAC`	2	K/E	mis¹ int¹ ese³		11	NA EU EA WA	974
	rs2901298^1,2	A,F,H	123738831(-)	`gagagG/Aaatga`	2	--	ut5¹		4	EU EA WA	408
	rs7083331^1,2	C,F,H	123960163(+)	`CCCCAT/CCTCTA`	4	T/I	mis¹ ese³		9	EU EA WA NA	892

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HapMap Linkage Disequilibrium images for TACC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605302

3 Novoseek disease relationships for TACC2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	37.03	1	15226440 (1)
cancer	9.69	1	15226440 (1)
tumors	0.00	5	15226440 (4), 14603251 (1)

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Human Genome Epidemiology Navigator: TACC2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/24 PubMed articles for TACC2 gene (see all 24 ):

The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)^{2, 3, 4} Gangisetty O.... Still I.H. (2004)
TTK kinase is essential for the centrosomal localization of TACC2. (PubMed id 15304323)^{1, 3, 4} Dou Z.... Yao X. (2004)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PubMed id 12620397)^{3, 4} Lauffart B.... Still I.H. (2003)
Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. (PubMed id 11161455)^{3, 4} Pu J.J.... Banerjee D. (2001)
AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. (PubMed id 10749935)^{3, 4} Chen H.-M....Bissell M.J. (2000)
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PubMed id 11121038)^{3, 4} Gergely F....Raff J.W. (2000)
TACC3 expression is tightly regulated during early differentiation. (PubMed id 12711550)^{1, 3} Sadek C.M....Gustafsson J.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10579	HGNC: 11523	AceView: TACC2	Ensembl:ENSG00000138162	euGenes: HUgn10579
ECgene: TACC2	H-InvDB: TACC2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TACC2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TACC2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TACC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TACC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TACC2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TACC2		Browse small molecules at Sigma-Aldrich
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TACC2 Gene at Home site.
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TACC2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for TACC2

Summaries
for TACC2

Genomic Location
for TACC2

Proteins
for TACC2

Protein Domains/
Families
for TACC2

Gene Function
for TACC2

Pathways & Interactions
for TACC2

Drugs & Compounds
for TACC2

Transcripts
for TACC2

Expression
for TACC2

Orthologs
for TACC2

Paralogs
for TACC2

SNPs/Variants
for TACC2

Disorders & Mutations
for TACC2

Medical News
for TACC2

Publications
for TACC2

Search for TACC2

Genome Databases showing TACC2

Other Databases showing TACC2

Specialized Databases showing TACC2

Licensable Technologies
for TACC2

Services
for TACC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TACC2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor TACC2

Summariesfor TACC2

Genomic Locationfor TACC2

Proteinsfor TACC2

Protein Domains/Familiesfor TACC2

Gene Functionfor TACC2

Pathways & Interactionsfor TACC2

Drugs & Compoundsfor TACC2

Transcriptsfor TACC2

Expression for TACC2

Orthologsfor TACC2

Paralogsfor TACC2

SNPs/Variantsfor TACC2

Disorders & Mutationsfor TACC2

Medical Newsfor TACC2

Publicationsfor TACC2

Search for TACC2

Genome Databases showing TACC2

Other Databases showing TACC2

Specialized Databases showing TACC2

Licensable Technologiesfor TACC2

Servicesfor TACC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TACC2

Summaries
for TACC2

Genomic Location
for TACC2

Proteins
for TACC2

Protein Domains/
Families
for TACC2

Gene Function
for TACC2

Pathways & Interactions
for TACC2

Drugs & Compounds
for TACC2

Transcripts
for TACC2

Expression
for TACC2

Orthologs
for TACC2

Paralogs
for TACC2

SNPs/Variants
for TACC2

Disorders & Mutations
for TACC2

Medical News
for TACC2

Publications
for TACC2

Licensable Technologies
for TACC2

Services
for TACC2