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Aliases for TACC2 Gene

Aliases for TACC2 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 2 2 3 5
  • AZU-1 3 4
  • Transforming, Acidic Coiled-Coil Containing Protein 2 2
  • Transforming Acidic Coiled-Coil-Containing Protein 2 3
  • Anti Zuai-1 3
  • Anti-Zuai-1 4
  • EC 2.4.2.10 61
  • EC 4.3.2.1 61
  • EC 6.3.5.2 61
  • ECTACC 3

External Ids for TACC2 Gene

Previous GeneCards Identifiers for TACC2 Gene

  • GC10P122942
  • GC10P123166
  • GC10P123879
  • GC10P123446
  • GC10P123474
  • GC10P123738
  • GC10P117379

Summaries for TACC2 Gene

Entrez Gene Summary for TACC2 Gene

  • Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TACC2 Gene

TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and nuclear hormone receptor binding. An important paralog of this gene is TACC1.

UniProtKB/Swiss-Prot for TACC2 Gene

  • Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Gene Wiki entry for TACC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC2 Gene

Genomics for TACC2 Gene

Regulatory Elements for TACC2 Gene

Enhancers for TACC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F122099 0.5 ENCODE 30.2 +110.0 110007 0.2 OSR2 SMARCA4 POLR2A GLIS1 PRDM10 NR2F2 TACC2 GC10P122094 GC10M122162
GH10F122101 0.9 ENCODE 26.6 +113.2 113226 1.9 INSM2 ZNF76 KLF17 SIN3A FEZF1 ZNF2 ZEB1 ZNF366 ZNF391 FOS TACC2 GC10P122094 GC10M122162
GH10F122085 0.5 ENCODE 21.9 +96.6 96571 1.3 ZNF316 JUNB MAFG NFE2 ZIC2 TACC2 GC10P122094 GC10M122037
GH10F122088 0.4 ENCODE 20.4 +100.2 100248 1.6 CTCF PKNOX1 FEZF1 BMI1 RAD21 HIC1 SMC3 ETV6 FOS CREM TACC2 GC10P122094 GC10M122037
GH10F122111 1.3 FANTOM5 ENCODE 13 +125.7 125667 6.4 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF143 FOS ZNF263 TACC2 GC10P122094 GC10M122162
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TACC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACC2 Gene

Chromosome:
10
Start:
121,989,174 bp from pter
End:
122,254,545 bp from pter
Size:
265,372 bases
Orientation:
Plus strand

Genomic View for TACC2 Gene

Genes around TACC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC2 Gene

Proteins for TACC2 Gene

  • Protein details for TACC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95359-TACC2_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 2
    Protein Accession:
    O95359
    Secondary Accessions:
    • Q4VXL0
    • Q4VXL3
    • Q4VXL6
    • Q4VXL7
    • Q5U5T7
    • Q86WG6
    • Q86WG7
    • Q8TCK9
    • Q9BVQ1
    • Q9NZ41
    • Q9NZR5

    Protein attributes for TACC2 Gene

    Size:
    2948 amino acids
    Molecular mass:
    309427 Da
    Quaternary structure:
    • Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.
    SequenceCaution:
    • Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAF63433.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TACC2 Gene

neXtProt entry for TACC2 Gene

Selected DME Specific Peptides for TACC2 Gene

Post-translational modifications for TACC2 Gene

  • Phosphorylated by TTK; which is required for localization in centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TACC2 Gene

Protein Domains for TACC2 Gene

Graphical View of Domain Structure for InterPro Entry

O95359

UniProtKB/Swiss-Prot:

TACC2_HUMAN :
  • Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.
  • Belongs to the TACC family.
Domain:
  • Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC2: view

No data available for Gene Families for TACC2 Gene

Function for TACC2 Gene

Molecular function for TACC2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Enzyme Numbers (IUBMB) for TACC2 Gene

Gene Ontology (GO) - Molecular Function for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035257 nuclear hormone receptor binding IDA 15207008
genes like me logo Genes that share ontologies with TACC2: view
genes like me logo Genes that share phenotypes with TACC2: view

Animal Models for TACC2 Gene

MGI Knock Outs for TACC2:

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TACC2 Gene

Localization for TACC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC2 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACC2 Gene COMPARTMENTS Subcellular localization image for TACC2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TACC2: view

Pathways & Interactions for TACC2 Gene

SuperPathways for TACC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TACC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0008283 cell proliferation IBA --
GO:0021987 cerebral cortex development IBA --
genes like me logo Genes that share ontologies with TACC2: view

No data available for Pathways by source and SIGNOR curated interactions for TACC2 Gene

Transcripts for TACC2 Gene

Unigene Clusters for TACC2 Gene

Transforming, acidic coiled-coil containing protein 2:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16:
SP17: - - - - - - - - - - - -
SP18: - - - - - - - -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for TACC2 Gene

GeneLoc Exon Structure for
TACC2
ECgene alternative splicing isoforms for
TACC2

Expression for TACC2 Gene

mRNA expression in normal human tissues for TACC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TACC2 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for TACC2 Gene

This gene is overexpressed in Urine (13.4), Cervix (12.8), and Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TACC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TACC2 Gene:

TACC2

SOURCE GeneReport for Unigene cluster for TACC2 Gene:

Hs.501252

mRNA Expression by UniProt/SwissProt for TACC2 Gene:

O95359-TACC2_HUMAN
Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.
genes like me logo Genes that share expression patterns with TACC2: view

Primer Products

No data available for Protein tissue co-expression partners for TACC2 Gene

Orthologs for TACC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TACC2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TACC2 34 35
  • 78.95 (n)
cow
(Bos Taurus)
Mammalia TACC2 34 35
  • 78.41 (n)
mouse
(Mus musculus)
Mammalia Tacc2 34 16 35
  • 74.58 (n)
rat
(Rattus norvegicus)
Mammalia Tacc2 34
  • 73.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TACC2 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TACC2 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC2 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tacc2 34
  • 60.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9694 34
zebrafish
(Danio rerio)
Actinopterygii TACC2 35
  • 34 (a)
OneToOne
-- 34
fruit fly
(Drosophila melanogaster)
Insecta tacc 35
  • 12 (a)
OneToMany
Species where no ortholog for TACC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC2 Gene

ENSEMBL:
Gene Tree for TACC2 (if available)
TreeFam:
Gene Tree for TACC2 (if available)

Paralogs for TACC2 Gene

Paralogs for TACC2 Gene

genes like me logo Genes that share paralogs with TACC2: view

Variants for TACC2 Gene

Sequence variations from dbSNP and Humsavar for TACC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036381 A breast cancer sample
VAR_036382 A breast cancer sample
rs10047276 -- 122,006,177(+) ggcac(A/G)gtggc intron-variant
rs10047286 -- 122,007,892(+) AGTGG(A/G)TTAGT intron-variant
rs10047287 -- 122,007,936(+) TTGGC(A/G)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TACC2 Gene

Variant ID Type Subtype PubMed ID
dgv1407n54 CNV gain 21841781
dgv1408n54 CNV loss 21841781
esv1958270 CNV deletion 18987734
esv2666599 CNV deletion 23128226
esv275180 CNV gain+loss 21479260
esv34167 CNV loss 18971310
esv3624764 CNV loss 21293372
esv3624765 CNV loss 21293372
esv3624766 CNV loss 21293372
esv3624767 CNV loss 21293372
esv3624769 CNV loss 21293372
esv3624771 CNV loss 21293372
nsv1045815 CNV loss 25217958
nsv1051882 CNV loss 25217958
nsv467468 CNV loss 19166990
nsv519434 CNV loss 19592680
nsv521165 CNV loss 19592680
nsv526940 CNV loss 19592680
nsv552247 CNV loss 21841781
nsv552248 CNV loss 21841781
nsv825593 CNV gain 20364138
nsv832009 CNV loss 17160897
nsv951864 CNV deletion 24416366

Variation tolerance for TACC2 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.94; 94.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACC2 Gene

Human Gene Mutation Database (HGMD)
TACC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TACC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC2 Gene

Disorders for TACC2 Gene

Relevant External Links for TACC2

Genetic Association Database (GAD)
TACC2
Human Genome Epidemiology (HuGE) Navigator
TACC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACC2

No disorders were found for TACC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TACC2 Gene

Publications for TACC2 Gene

  1. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PMID: 14767476) Gangisetty O. … Still I.H. (Oncogene 2004) 2 3 4 64
  2. TTK kinase is essential for the centrosomal localization of TACC2. (PMID: 15304323) Dou Z. … Yao X. (FEBS Lett. 2004) 3 4 22 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance. (PMID: 20335520) Cheng S. … Jiang W.G. (Cancer Genomics Proteomics 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for TACC2 Gene

Sources for TACC2 Gene

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