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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TACC2 Gene

protein-coding   GIFtS: 58
GCID: GC10P123738

Transforming, Acidic Coiled-Coil Containing Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transforming, Acidic Coiled-Coil Containing Protein 21 2     Anti-Zuai-13
AZU-12 3     EC 2.4.2.108
ECTACC2     EC 4.3.2.18
Anti Zuai-12     EC 6.3.5.28
Transforming Acidic Coiled-Coil-Containing Protein 22     

External Ids:    HGNC: 115231   Entrez Gene: 105792   Ensembl: ENSG000001381627   OMIM: 6053025   UniProtKB: O953593   

Export aliases for TACC2 gene to outside databases

Previous GC identifers: GC10P122942 GC10P123166 GC10P123879 GC10P123446 GC10P123474 GC10P117379


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TACC2 Gene:
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting
proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout
the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene
is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TACC2 Gene: 
TACC2 (transforming, acidic coiled-coil containing protein 2) is a protein-coding gene. Diseases associated with TACC2 include fanconi's anemia, and multiple myeloma. GO annotations related to this gene include nuclear hormone receptor binding and protein domain specific binding. An important paralog of this gene is TACC3.

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359
Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May
represent a tumor progression marker

Gene Wiki entry for TACC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TACC2 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-6   FOXD1   AP-4   E2F-2   PPAR-alpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TACC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TACC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TACC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

TACC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACC2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P123738:  view genomic region     (about GC identifiers)

Start:
123,748,689 bp from pter      End:
124,014,060 bp from pter
Size:
265,372 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359 (See protein sequence)
Recommended Name: Transforming acidic coiled-coil-containing protein 2  
Size: 2948 amino acids; 309427 Da
Subunit: Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2
and PCAF
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Developmental stage: Expressed in fetal brain, lung, liver and kidney
Sequence caution: Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAF63433.1;
Type=Erroneous initiation;
Secondary accessions: Q4VXL0 Q4VXL3 Q4VXL6 Q4VXL7 Q5U5T7 Q86WG6 Q86WG7 Q8TCK9 Q9BVQ1 Q9NZ41
Q9NZR5
Alternative splicing: 6 isoforms:  O95359-4   O95359-1   O95359-2   O95359-3   O95359-5   O95359-6   (Contains a phosphothreonine at position 2625)

Explore the universe of human proteins at neXtProt for TACC2: NX_O95359

Explore proteomics data for TACC2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by TTK; which is required for localization in centrosome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95359

  • 3 DME Specific Peptides for TACC2 (O95359)
     ASTPSCP  DAYSTGSS  LASGLPSP 

    TACC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TACC2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_008928.1  NP_996742.1  NP_996743.1  NP_996744.2  

    ENSEMBL proteins: 
     ENSP00000358001   ENSP00000425062   ENSP00000424467   ENSP00000427618   ENSP00000423069  
     ENSP00000357997   ENSP00000357996   ENSP00000353763   ENSP00000357995   ENSP00000422815  
     ENSP00000260733   ENSP00000420967   ENSP00000421702   ENSP00000426303   ENSP00000422725  
     ENSP00000425525   ENSP00000423764   ENSP00000334280   ENSP00000350701   ENSP00000395048  

    Human Recombinant Protein Products for TACC2: 
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    Novus Biologicals TACC2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TACC2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005815microtubule organizing center IEA--

    TACC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007707 TACC

    Graphical View of Domain Structure for InterPro Entry O95359

    ProtoNet protein and cluster: O95359

    1 Blocks protein domain: IPB007707 Transforming acidic coiled-coil-containing

    UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359
    Similarity: Belongs to the TACC family
    Similarity: Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain


    TACC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TACC2_HUMAN, O95359
    Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the
    processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By
    similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May
    represent a tumor progression marker

         Enzyme Numbers (IUBMB): EC 4.3.2.12 EC 2.4.2.102 EC 6.3.5.22

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019904protein domain specific binding IEA--
    GO:0035257nuclear hormone receptor binding IDA15207008
         
    TACC2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TACC2:
     Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tacc2):
     normal  tumorigenesis 

    TACC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tacc2tm1Jni for TACC2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TACC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TACC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TACC2 
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    SwitchGear 3'UTR luciferase reporter plasmidTACC2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TACC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/19 Interacting proteins for TACC2 (O953592, 3 ENSP000003342804) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTKP339812, 3, ENSP000002305104MINT-50599 MINT-50600 I2D: score=1 STRING: ENSP00000230510
    RXRBP287023, ENSP000003638124I2D: score=1 STRING: ENSP00000363812
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0008283cell proliferation ----
    GO:0021987cerebral cortex development IEA--
    GO:0022008neurogenesis IEA--
    GO:0022027interkinetic nuclear migration IEA--

    TACC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TACC2

    Search CenterWatch for drugs/clinical trials and news about TACC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TACC2 gene (4 alternative transcripts): 
    NM_006997.2  NM_206860.1  NM_206861.1  NM_206862.2  

    Unigene Clusters for TACC2:

    Transforming, acidic coiled-coil containing protein 2
    Hs.501252  [show with all ESTs], Hs.713875  [show with all ESTs]
    Unigene Representative Sequences: AF528099, BC029124
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000492689 ENST00000369005(uc001lfv.3 uc009xzx.3 uc010qtv.2)
    ENST00000513429(uc001lfw.3) ENST00000515273 ENST00000515603 ENST00000498721
    ENST00000474014 ENST00000489754 ENST00000491540 ENST00000493951 ENST00000369001(uc001lfx.3)
    ENST00000492237 ENST00000369000(uc001lfy.3) ENST00000360561(uc001lga.3 uc009xzy.3)
    ENST00000368999(uc001lfz.3) ENST00000369004 ENST00000260733 ENST00000514539(uc010qtw.1)


    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TACC2 (see all 28):
    hsa-miR-3910 hsa-miR-217 hsa-miR-125a-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-1278 hsa-miR-3129-5p hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidTACC2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TACC2

    Additional mRNA sequence: BC029124.1 

    24/29 DOTS entries (see all 29):

    DT.92436580  DT.91785837  DT.100821624  DT.102835591  DT.100821621  DT.97787283  DT.117550  DT.91665866 
    DT.121239147  DT.121239228  DT.95188118  DT.100741568  DT.121239237  DT.100000873  DT.91661197  DT.92032483 
    DT.95115888  DT.95319329  DT.101975725  DT.121239160  DT.97843751  DT.97859639  DT.121239208  DT.121239270 

    24/277 AceView cDNA sequences (see all 277):

    BU689821 AA935720 BG696788 AI679077 AK056743 AA132922 AW850463 AF095791 
    F13192 AI564711 BQ011915 CA447782 CB216286 F10797 AI539158 NM_206860 
    AI299389 CF528324 F01663 CF528952 AL713712 BC039311 BU622761 H91589 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TACC2 (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f · 14g ^
    SP1:                                -     -     -     -     -     -                 -     -     -                 -     -                                       
    SP2:              -     -     -     -     -     -     -     -     -           -     -     -     -                 -     -                                       
    SP3:                                                                                            -                 -     -                                       
    SP4:                                                                          -     -     -     -                 -     -                                       
    SP5:                                                                                            -                 -     -                                       

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
    SP1:              -                                                                       -           -                                       
    SP2:              -                                                                       -           -                                       
    SP3:              -                                                                       -           -                                       
    SP4:              -     -                                         -     -                 -           -                                       
    SP5:              -                                                     -                 -           -                                       


    ECgene alternative splicing isoforms for TACC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TACC2 expression in normal human tissues (normalized intensities)      TACC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACATTC
    TACC2 Expression
    About this image


    TACC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urogenital sinus/nerves of urogenital sinus   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See TACC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TACC2

    SOURCE GeneReport for Unigene clusters: Hs.501252 Hs.713875

    UniProtKB/Swiss-Prot: TACC2_HUMAN, O95359
    Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TACC2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacc21 , 5 transforming, acidic coiled-coil containing protein more1, 5 74.51(n)1
    63.52(a)1
      7 (73.19 cM)5
    577521  NM_001004468.21  NP_001004468.11 
     1305774845 
    chicken
    (Gallus gallus)
    Aves TACC21 transforming, acidic coiled-coil containing protein more 74.11(n)
    74.88(a)
      423939  XM_421798.3  XP_421798.3 
    lizard
    (Anolis carolinensis)
    Reptilia TACC26
    Uncharacterized protein
    61(a)
    1 ↔ 1
    3(64117888-64360400)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96942 Xenopus laevis transcribed sequence with weak similarity more 85.62(n)    BJ084975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ169353.12   -- 77.8(n)   321181  BQ169353.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tacc6
    transforming acidic coiled-coil protein
    8(a)
    1 → many
    3R(559376-574778)


    ENSEMBL Gene Tree for TACC2 (if available)
    TreeFam Gene Tree for TACC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TACC2 gene
    TACC32  TACC12  
    2 SIMAP similar genes for TACC2 using alignment to 15 protein entries:     TACC2_HUMAN (see all proteins):
    TACC1    TACC3

    TACC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6611 SNPs in TACC2 are shown (see all 6611)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363814
    A breast cancer sample4--see VAR_0363812 L V mis40--------
    VAR_0363824
    A breast cancer sample4--see VAR_0363822 A S mis40--------
    rs57885271,2
    C,F--117413185(+) TACAAT/-TTTTT 2 -- int1 trp33Minor allele frequency- -:0.33NA 6
    rs679411381,2
    C,F--117418983(+) TCCCCT/ACCCCT 2 -- int14Minor allele frequency- A:0.31NA WA CSA 125
    rs1404002451,2
    C--117449035(+) CTAAT-/TTGTTGTT 2 -- int10--------
    rs1999224301,2
    --117449040(+) TTGTT-/GTTGTT 2 -- int10--------
    rs45329731,2
    C,F--117450971(+) CATCTC/TAAAAA 2 -- int12Minor allele frequency- T:0.50NA 4
    rs1398686181,2
    C--117453793(+) CACAC-/AC/   
      ACACAC
    CCTTA
    4 -- int1 cds10--------
    rs105532521,2
    C--117453794(+) ataat-/ACacaca 2 -- int10--------
    rs1115979131,2
    C--117458630(+) AAACCT/-TTTTT 2 -- int11Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for TACC2 (123748689 - 123998689 bp, first 250kb of TACC2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for TACC2 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1958270CNV Deletion18987734
    esv2742073CNV Deletion23290073
    esv2742084CNV Deletion23290073
    esv2666599CNV Deletion23128226
    dgv831n71CNV Loss21882294
    nsv896051CNV Loss21882294
    nsv526940CNV Loss19592680
    dgv830n71CNV Loss21882294
    nsv896054CNV Loss21882294
    nsv467468CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605302    OMIM disorders: --

    14 diseases for TACC2:    About MalaCards
    fanconi's anemia    multiple myeloma    myeloma    acute lymphoblastic leukemia
    anemia    lymphoblastic leukemia    cerebritis    breast cancer
    alzheimer's disease    thyroiditis    prostate cancer    endotheliitis
    leukemia    prostatitis


    TACC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for TACC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 38 6 20335520 (4), 15226440 (1)
    cancer 12.6 2 15226440 (1), 20335520 (1)
    tumors 0 5 15226440 (4), 14603251 (1)

    Genetic Association Database (GAD): TACC2
    Human Genome Epidemiology (HuGE) Navigator: TACC2 (4 documents)

    Export disorders for TACC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TACC2 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with TACC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)1, 2, 3 Gangisetty O.... Still I.H. (2004)
    2. TTK kinase is essential for the centrosomal localization of TACC2. (PubMed id 15304323)1, 2, 9 Dou Z.... Yao X. (2004)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. (PubMed id 12620397)1, 2 Lauffart B.... Still I.H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10579 HGNC: 11523 AceView: TACC2 Ensembl:ENSG00000138162 euGenes: HUgn10579
    ECgene: TACC2 H-InvDB: TACC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TACC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TACC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TACC2 gene:
    Search GeneIP for patents involving TACC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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