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TACC1 Gene

protein-coding GIFtS: 59

GC08P038733

transforming, acidic coiled-coil containing protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp686K18126 ^²
FLJ42304 ^²
Ga55 ^²
KIAA1103 ^², ³

Descriptions
Gastric cancer antigen Ga55 ^², ³
Taxin 1 ^², ³
transforming, acidic coiled-coil containing protein 1 ^²

External Ids
HGNC: 11522¹
Entrez Gene: 6867²
UniProtKB: O75410³
Ensembl: ENSG00000147526⁷

Search outside databases for aliases for TACC1 gene

Previous GC identifers: GC08P038196 GC08P038859 GC08P038326 GC08P038603

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TACC1:

This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region

of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding

different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410

Function: Likely involved in the processes that promote cell division prior to the formation of

differentiated tissues

Gene Wiki entry for TACC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TACC1 gene

Entrez Gene cytogenetic band: 8p11.23 Ensembl cytogenetic band: 8p11.23 HGNC cytogenetic band: 8p11

TACC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P038733: (about GC identifiers)

Start:	38,734,008 bp from pter
End:	38,829,703 bp from pter
Size:	95,696 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410 (See protein sequence)

Recommended Name: Transforming acidic coiled-coil-containing protein 1

Size: 805 amino acids; 87794 Da

Subunit: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4.

Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG.

Interacts with GCN5L2 and PCAF

Subcellular location: Cytoplasm. Nucleus. Note=Nucleus during interphase. Weakly concentrated at

centrosomes during mitosis

Developmental stage: Expressed at high level during early embryogenesis

Miscellaneous: Down-regulated in a subset of cases of breast cancer

Secondary accessions: Q6Y687 Q86YG7 Q8IUJ2 Q8IUJ3 Q8IUJ4 Q8IZG2 Q8NEY7 Q9UPP9

Alternative splicing: 8 isoforms: O75410-1 O75410-2 O75410-3 O75410-4 O75410-5 O75410-6 O75410-7 O75410-8

(Additional isoforms seem to exist)

Post-translational modifications:

Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by

ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001116296.1 NP_001139688.1 NP_006274.2

ENSEMBL proteins:

ENSP00000369263 ENSP00000321703 ENSP00000332794 ENSP00000276520 ENSP00000327818

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TACC1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for TACC1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TACC1
	Sigma-Aldrich Antibodies for TACC1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TACC1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for TACC1

Assays for TACC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75410

ProtoNet protein and cluster: O75410

1 Blocks protein family: IPB007707 Transforming acidic coiled-coil-containing

UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410

Similarity: Belongs to the TACC family

Similarity: Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACC1)
		Millipore RNAi Products for the Analysis of TACC1 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006283

Applied Biosystems Silencer® siRNAs for TACC1

Sigma-Aldrich siRNA and siRNA Panels for TACC1

Sigma-Aldrich shRNA for TACC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122824
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122824
untagged cDNA clones in CMV expression vector (see all 2): NM_001122824

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006283

UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410

Function: Likely involved in the processes that promote cell division prior to the formation of

differentiated tissues

Genatlas biochemistry entry for TACC1:

transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially

promoting tumorigenicity in breast cancers with amplification of the 8p11 region

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11903063 12165861 14603251 15064709

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TACC1

5/8 Interacting proteins for TACC1 (ENSP00000369263³ O75410¹) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AURKA	O14965¹	STRING (score=.986) EBI-624252, EBI-448680
AURKB	Q96GD4¹	STRING (score=.96) EBI-624278, EBI-624291
CKAP5	Q14008¹	STRING (score=.999) EBI-624237, EBI-310585
LSM7	Q9UK45¹	STRING (score=.959) EBI-624278, EBI-348372
SNRPG	P62308¹	STRING (score=.873) EBI-624278, EBI-624585

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0051301	cell division	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TACC1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TACC1)
		Millipore RNAi Products for the Analysis of TACC1 Gene knock-down
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006283

Sigma-Aldrich siRNA and siRNA Panels for TACC1

Sigma-Aldrich shRNA for TACC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122824 NM_006283

REFSEQ mRNAs for TACC1 gene (3 alternative transcripts):

NM_001122824.1 NM_001146216.1 NM_006283.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122824 NM_006283

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122824
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122824
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001122824

Additional cDNA sequence:

AB029026.1 AF049910.1 AF075051.1 AK057659.1 AK098223.1 AK124297.1 AK129750.1 AK294931.1

AK295071.1 AK295841.1 AK303596.1 AK304507.1 AK304725.1 AK304774.1 AK308849.1 AK314620.1

AY039239.1 AY072873.2 AY072874.1 AY072875.1 AY072876.2 AY139007.1 AY177411.1 BC041391.1

BX647696.1 CR605417.1 CR933618.1

24/25 DOTS entries (see all 25 ):

DT.445878 DT.75170359 DT.95240638 DT.100797363 DT.100031422 DT.40125901 DT.92006861 DT.120636115

DT.425248 DT.100031423 DT.95222429 DT.100010104 DT.100737639 DT.100797378 DT.120636076 DT.120636091

DT.120636160 DT.40233461 DT.95120300 DT.100736149 DT.100797361 DT.91680115 DT.91955944 DT.95075498

24/520 AceView cDNA sequences (see all 520 ):

BQ005713 BQ893716 AY072874 AA548642 AW664151 AY072876 AA180487 AA809926

BF063977 CD676485 BF438914 AW072909 BU174798 BE677181 AA179734 AI271933

BQ024487 AA279849 AI499959 AI143983 BU677937 BF222694 AI804791 CB217090

highest scoring ESTs for TACC1:

AF049910 AA002089 AA002134 AA010119 AA010120 AA013486 AA026546 AA026547 AA029318 AA029870

Unigene Cluster for TACC1:

Transforming, acidic coiled-coil containing protein 1

Hs.279245 [show with all ESTs]

Unigene Representative Sequence: CR933618

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 (see all 16 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	·
SP1:											-		-				-		-																-														-		-
SP2:																	-		-																-						-								-		-
SP3:											-		-		-		-		-		-		-		-		-		-		-		-		-														-		-
SP4:																																																	-		-
SP5:																																																	-		-

ExUns:	16c	^	17	^	18a	·	18b	^	19a	·	19b	^	20
SP1:							-		-
SP2:							-		-
SP3:							-		-
SP4:							-		-
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for TACC1

5 Ensembl transcripts including schematic representations:

ENST00000379931 ENST00000317827 ENST00000330691 ENST00000276520 ENST00000348567

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TACC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TACC1

¹ / ² / ³

9 probe-sets matching TACC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40841_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF049910	1.00	1.00	1.00	1
200911_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006283	0.60	1.00	0.82	1
217437_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB029026	0.80	1.00	0.91	1
242290_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE676272	0.60	1.00	0.82	1
200911_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554690_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217437_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242290_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557305_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTCATTGCC

SOURCE GeneReport for Unigene cluster: Hs.279245
Expression variation in blood from EXPOLDB for TACC1
UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410
Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly
expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer.
Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer
tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TACC1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TACC1¹	--	transforming, acidic coiled-coil containing protein more	87.2(n) 85.81(a)	475581 XM_532800.2 XP_532800.2
chimpanzee (Pan troglodytes)	TACC1¹	--	transforming, acidic coiled-coil containing protein more	99.54(n) 99.5(a)	464124 XM_001171659.1 XP_001171659.1
cow (Bos taurus)	TACC1¹	--	transforming, acidic coiled-coil containing protein more	78.77(n) 75.69(a)	507012 XM_583551.3 XP_583551.3
rat (Rattus norvegicus)	Tacc1¹	--	transforming, acidic coiled-coil containing protein more	80.3(n) 76.69(a)	306562 NM_001004107.1 NP_001004107.1
mouse (Mus musculus)	Tacc1^{1, 5}	8⁵	transforming, acidic coiled-coil containing protein more^{1, 5}	80.11(n)¹ 77.3(a)¹	320165¹ NM_177089.4¹ NP_796063.3¹ AA960202⁵ AI843308⁵ (see all 22)

About this table Species with no ortholog for TACC1

ENSEMBL Gene Tree for TACC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TACC1 gene

TACC3² TACC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/253 NCBI SNPs in TACC1 are shown (see all 253 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 105)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6980553^1,2	A,C,F,H	38796647(+)	`AGCAAT/CTGGAG`	1	T/I	mis¹		11	EU EA WA NA	980
	rs1802267^1,2	C,F,H,O	38825526(+)	`ATGAAC/TGGCAA`	2	--	ut3¹ ese³		11	NA EU EA WA	922
	rs1135990^1,2	C,F,H,O	38828710(+)	`CTCTCC/TTCTCA`	2	--	ut3¹ ese³ trp³		13	MN NA EA EU WA	1234
	rs17514831^1,2	C,F,H	38826941(+)	`TTATGA/CGGAAA`	2	--	ut3¹ ese³		11	NA EU EA WA	980
	rs4577922^1,2	C,F,H	38828559(+)	`CCTTCA/GAATAC`	2	--	ut3¹		4	EU EA WA	420
	rs3802249^1,2	C,F,H	38825554(+)	`GCTAGG/CGTTTG`	2	--	ut3¹		7	NA EU EA WA	546
	rs11467^1,2	A,C,F	38764071(+)	`GACGCA/GGCGCC`	2	--	ut5¹ ese³		1	MN	184
--	rs34235313^1,2	C,F	38796479(-)	`CTGGCG/AGGCTG`	1	L/P	mis¹		5	NA EU EA WA	496
	rs16887801^1,2	F,H	38826692(+)	`TTTATA/GTTGAT`	2	--	ut3¹ ese³		7	NA EU EA WA	542
	rs3739251^1,2	F,H	38826609(+)	`AGTTAA/TTTTTG`	2	--	ut3¹		4	EU EA WA	386

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HapMap Linkage Disequilibrium images for TACC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605301

5 Novoseek disease relationships for TACC1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	47.42	10	18984771 (3), 10435627 (2), 16288026 (1), 12165861 (1) (see all 6)
ovarian cancer	21.47	1	15918899 (1)
gastric cancer	20.33	3	12547166 (3)
tumors	20.17	10	15918899 (3), 16288026 (1), 18709641 (1), 17321332 (1) (see all 8)
cancer	19.97	2	12165861 (1), 15918899 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/33 PubMed articles for TACC1 gene (see all 33 ):

Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)^{1, 3, 4} Conte N.... Birnbaum D. (2002)
Altered splicing pattern of TACC1 mRNA in gastric cancer. (PubMed id 12547166)^{1, 3, 4} Line A.... Rees R.C. (2002)
Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. (PubMed id 10435627)^{1, 3, 4} Still I.H.... Cowell J.K. (1999)
Aurora B -TACC1 protein complex in cytokinesis. (PubMed id 15064709)^{1, 3, 4} Delaval B.... Birnbaum D. (2004)
TACC1-chTOG-Aurora A protein complex in breast cancer. (PubMed id 14603251)^{1, 3, 4} Conte N.... Birnbaum D. (2003)
Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PubMed id 11903063)^{1, 3, 4} Lauffart B....Still I.H. (2002)
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PubMed id 11121038)^{1, 3, 4} Gergely F....Raff J.W. (2000)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. (PubMed id 14767476)^{3, 4} Gangisetty O.... Still I.H. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6867	HGNC: 11522	AceView: TACC1	Ensembl:ENSG00000147526	euGenes: HUgn6867
ECgene: TACC1	H-InvDB: TACC1

(According to HUGE)
About This Section

HUGE: KIAA1103

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TACC1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TACC1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TACC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TACC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TACC1		Antibodies for TACC1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TACC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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TACC1 Gene at Home site.
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TACC1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for TACC1

Summaries
for TACC1

Genomic Location
for TACC1

Proteins
for TACC1

Protein Domains/
Families
for TACC1

Gene Function
for TACC1

Pathways & Interactions
for TACC1

Drugs & Compounds
for TACC1

Transcripts
for TACC1

Expression
for TACC1

Orthologs
for TACC1

Paralogs
for TACC1

SNPs/Variants
for TACC1

Disorders & Mutations
for TACC1

Medical News
for TACC1

Publications
for TACC1

Search for TACC1

Genome Databases showing TACC1

Other Databases showing TACC1

Specialized Databases showing TACC1

Licensable Technologies
for TACC1

Services
for TACC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TACC1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor TACC1

Summariesfor TACC1

Genomic Locationfor TACC1

Proteinsfor TACC1

Protein Domains/Familiesfor TACC1

Gene Functionfor TACC1

Pathways & Interactionsfor TACC1

Drugs & Compoundsfor TACC1

Transcriptsfor TACC1

Expression for TACC1

Orthologsfor TACC1

Paralogsfor TACC1

SNPs/Variantsfor TACC1

Disorders & Mutationsfor TACC1

Medical Newsfor TACC1

Publicationsfor TACC1

Search for TACC1

Genome Databases showing TACC1

Other Databases showing TACC1

Specialized Databases showing TACC1

Licensable Technologiesfor TACC1

Servicesfor TACC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TACC1

Summaries
for TACC1

Genomic Location
for TACC1

Proteins
for TACC1

Protein Domains/
Families
for TACC1

Gene Function
for TACC1

Pathways & Interactions
for TACC1

Drugs & Compounds
for TACC1

Transcripts
for TACC1

Expression
for TACC1

Orthologs
for TACC1

Paralogs
for TACC1

SNPs/Variants
for TACC1

Disorders & Mutations
for TACC1

Medical News
for TACC1

Publications
for TACC1

Licensable Technologies
for TACC1

Services
for TACC1