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Aliases for TACC1 Gene

Aliases for TACC1 Gene

  • Transforming Acidic Coiled-Coil Containing Protein 1 2 3
  • Transforming, Acidic Coiled-Coil Containing Protein 1 2 5
  • Gastric Cancer Antigen Ga55 3 4
  • Taxin-1 3 4
  • KIAA1103 4
  • Ga55 3

External Ids for TACC1 Gene

Previous GeneCards Identifiers for TACC1 Gene

  • GC08P038196
  • GC08P038859
  • GC08P038326
  • GC08P038603
  • GC08P038733
  • GC08P038586
  • GC08P037121

Summaries for TACC1 Gene

Entrez Gene Summary for TACC1 Gene

  • This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for TACC1 Gene

TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1) is a Protein Coding gene. Diseases associated with TACC1 include gliosarcoma and giant cell glioblastoma. Among its related pathways are Aurora A signaling and Aurora B signaling. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC2.

UniProtKB/Swiss-Prot for TACC1 Gene

  • Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

Gene Wiki entry for TACC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TACC1 Gene

Genomics for TACC1 Gene

Regulatory Elements for TACC1 Gene

Promoters for TACC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TACC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TACC1 Gene

Chromosome:
8
Start:
38,728,186 bp from pter
End:
38,853,028 bp from pter
Size:
124,843 bases
Orientation:
Plus strand

Genomic View for TACC1 Gene

Genes around TACC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TACC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TACC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TACC1 Gene

Proteins for TACC1 Gene

  • Protein details for TACC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75410-TACC1_HUMAN
    Recommended name:
    Transforming acidic coiled-coil-containing protein 1
    Protein Accession:
    O75410
    Secondary Accessions:
    • B2RBD9
    • D3DSX6
    • Q6Y687
    • Q86YG7
    • Q8IUJ2
    • Q8IUJ3
    • Q8IUJ4
    • Q8IZG2
    • Q8NEY7
    • Q9UPP9

    Protein attributes for TACC1 Gene

    Size:
    805 amino acids
    Molecular mass:
    87794 Da
    Quaternary structure:
    • Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.

    Alternative splice isoforms for TACC1 Gene

neXtProt entry for TACC1 Gene

Proteomics data for TACC1 Gene at MOPED

Post-translational modifications for TACC1 Gene

Antibody Products

No data available for DME Specific Peptides for TACC1 Gene

Domains & Families for TACC1 Gene

Protein Domains for TACC1 Gene

Graphical View of Domain Structure for InterPro Entry

O75410

UniProtKB/Swiss-Prot:

TACC1_HUMAN :
  • Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
  • Belongs to the TACC family.
Domain:
  • Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
Family:
  • Belongs to the TACC family.
genes like me logo Genes that share domains with TACC1: view

No data available for Gene Families for TACC1 Gene

Function for TACC1 Gene

Molecular function for TACC1 Gene

GENATLAS Biochemistry:
transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially promoting tumorigenicity in breast cancers with amplification of the 8p11 region
UniProtKB/Swiss-Prot Function:
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
genes like me logo Genes that share phenotypes with TACC1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TACC1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TACC1 Gene

Localization for TACC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TACC1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269 PubMed:21531210}.
Isoform 5: Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TACC1 Gene COMPARTMENTS Subcellular localization image for TACC1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IEA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TACC1: view

Pathways & Interactions for TACC1 Gene

genes like me logo Genes that share pathways with TACC1: view

Pathways by source for TACC1 Gene

2 BioSystems pathways for TACC1 Gene

Gene Ontology (GO) - Biological Process for TACC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TACC1: view

No data available for SIGNOR curated interactions for TACC1 Gene

Drugs & Compounds for TACC1 Gene

No Compound Related Data Available

Transcripts for TACC1 Gene

Unigene Clusters for TACC1 Gene

Transforming, acidic coiled-coil containing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - -
SP12: - - -
SP13: - -
SP14:
SP15:
SP16:

ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TACC1 Gene

GeneLoc Exon Structure for
TACC1
ECgene alternative splicing isoforms for
TACC1

Expression for TACC1 Gene

mRNA expression in normal human tissues for TACC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TACC1 Gene

This gene is overexpressed in Liver (20.7) and Peripheral blood mononuclear cells (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TACC1 Gene



SOURCE GeneReport for Unigene cluster for TACC1 Gene Hs.279245

mRNA Expression by UniProt/SwissProt for TACC1 Gene

O75410-TACC1_HUMAN
Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
genes like me logo Genes that share expression patterns with TACC1: view

Protein tissue co-expression partners for TACC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TACC1 Gene

Orthologs for TACC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TACC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TACC1 35
  • 79.96 (n)
  • 77.22 (a)
TACC1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TACC1 35
  • 87.62 (n)
  • 86.32 (a)
TACC1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tacc1 35
  • 80.16 (n)
  • 77.43 (a)
Tacc1 16
Tacc1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TACC1 35
  • 99.63 (n)
  • 99.63 (a)
TACC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tacc1 35
  • 80.34 (n)
  • 76.82 (a)
oppossum
(Monodelphis domestica)
Mammalia TACC1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TACC1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TACC1 35
  • 69.05 (n)
  • 68.93 (a)
TACC1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TACC1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5836 35
tacc1 35
  • 65.44 (n)
  • 63.64 (a)
zebrafish
(Danio rerio)
Actinopterygii tacc1 35
  • 57.17 (n)
  • 52.75 (a)
tacc1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tacc 36
  • 10 (a)
OneToMany
Species with no ortholog for TACC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TACC1 Gene

ENSEMBL:
Gene Tree for TACC1 (if available)
TreeFam:
Gene Tree for TACC1 (if available)

Paralogs for TACC1 Gene

Paralogs for TACC1 Gene

Pseudogenes.org Pseudogenes for TACC1 Gene

genes like me logo Genes that share paralogs with TACC1: view

Variants for TACC1 Gene

Sequence variations from dbSNP and Humsavar for TACC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34235313 - 38,819,804(-) CTGGC(A/G)GGCTG intron-variant, reference, missense, utr-variant-5-prime
rs6980553 - 38,819,972(+) AGCAA(C/T)TGGAG intron-variant, reference, missense
rs10107016 - 38,820,008(+) TGTGG(A/G)GGGCA intron-variant, reference, missense
rs11467 -- 38,787,396(+) GACGC(A/G)GCGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs14128 -- 38,848,695(+) TTAAA(A/G)ATGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TACC1 Gene

Variant ID Type Subtype PubMed ID
nsv831296 CNV Gain 17160897
esv25816 CNV Loss 19812545
nsv396891 CNV Insertion 16902084
nsv528721 CNV Loss 19592680

Variation tolerance for TACC1 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TACC1 Gene

HapMap Linkage Disequilibrium report
TACC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TACC1 Gene

Disorders for TACC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TACC1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gliosarcoma
  • glioblastoma with sarcomatous component
giant cell glioblastoma
  • monstrocellular sarcoma [obs]
gastric cancer
  • stomach cancer
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search TACC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TACC1

Genetic Association Database (GAD)
TACC1
Human Genome Epidemiology (HuGE) Navigator
TACC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TACC1
genes like me logo Genes that share disorders with TACC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TACC1 Gene

Publications for TACC1 Gene

  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PMID: 12165861) Conte N. … Birnbaum D. (Oncogene 2002) 3 4 23 67
  2. Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer. (PMID: 18984771) Ghayad S.E. … Cohen P.A. (J. Mol. Endocrinol. 2009) 3 23
  3. Temporal and spatial expression of TACC1 in the mouse and human. (PMID: 16496324) Lauffart B. … Still I.H. (Dev. Dyn. 2006) 3 23
  4. Aurora B -TACC1 protein complex in cytokinesis. (PMID: 15064709) Delaval B. … Birnbaum D. (Oncogene 2004) 3 23
  5. TACC1-chTOG-Aurora A protein complex in breast cancer. (PMID: 14603251) Conte N. … Birnbaum D. (Oncogene 2003) 3 23

Products for TACC1 Gene

Sources for TACC1 Gene

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