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TACC1 Gene

protein-coding   GIFtS: 61
GCID: GC08P038586

Transforming, Acidic Coiled-Coil Containing Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transforming, Acidic Coiled-Coil Containing Protein 11 2     Transforming Acidic Coiled-Coil-Containing Protein 12
Gastric Cancer Antigen Ga552 3     KIAA11033
Ga552     Taxin-13
taxin-12     

External Ids:    HGNC: 115221   Entrez Gene: 68672   Ensembl: ENSG000001475267   OMIM: 6053015   UniProtKB: O754103   

Export aliases for TACC1 gene to outside databases

Previous GC identifers: GC08P038196 GC08P038859 GC08P038326 GC08P038603 GC08P038733 GC08P037121


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TACC1 Gene:
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8
that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for TACC1 Gene:
TACC1 (transforming, acidic coiled-coil containing protein 1) is a protein-coding gene. Diseases associated with TACC1 include gliosarcoma, and giant cell glioblastoma. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is TACC3.

UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410
Function: Likely involved in the processes that promote cell division prior to the formation of differentiated
tissues

Gene Wiki entry for TACC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TACC1 gene promoter:
         HSF1 (long)   Tal-1beta   Arnt   Evi-1   E47   Gfi-1   Sox9   FOXO1a   HSF1short   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): TACC1 promoter sequence
   Search Chromatin IP Primers for TACC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TACC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11

TACC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038586:  view genomic region     (about GC identifiers)

Start:
38,585,704 bp from pter      End:
38,710,546 bp from pter
Size:
124,843 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410 (See protein sequence)
Recommended Name: Transforming acidic coiled-coil-containing protein 1  
Size: 805 amino acids; 87794 Da
Subunit: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA,
AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF
Developmental stage: Expressed at high level during early embryogenesis
Secondary accessions: B2RBD9 D3DSX6 Q6Y687 Q86YG7 Q8IUJ2 Q8IUJ3 Q8IUJ4 Q8IZG2 Q8NEY7 Q9UPP9
Alternative splicing: 8 isoforms:  O75410-1   O75410-2   O75410-3   O75410-4   O75410-5   O75410-6   O75410-7   O75410-8   

Explore the universe of human proteins at neXtProt for TACC1: NX_O75410

Explore proteomics data for TACC1 at MOPED

Post-translational modifications: 

  • Isoform 1 is heavily phosphorylated; isoform 6 is not1
  • Ubiquitination2 at Lys169
  • Modification sites at PhosphoSitePlus

  • See TACC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001116296.1  NP_001139688.1  NP_006274.2  

    ENSEMBL proteins: 
     ENSP00000428687   ENSP00000428450   ENSP00000473342   ENSP00000428706   ENSP00000428466  
     ENSP00000428949   ENSP00000430355   ENSP00000430562   ENSP00000321703   ENSP00000276520  
     ENSP00000430819   ENSP00000430959   ENSP00000428175   ENSP00000429330   ENSP00000428253  
     ENSP00000430306   ENSP00000429418   ENSP00000393647   ENSP00000332794   ENSP00000327818  
     ENSP00000369263  

    TACC1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for TACC1

    TACC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for TACC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007707 TACC

    Graphical View of Domain Structure for InterPro Entry O75410

    ProtoNet protein and cluster: O75410

    1 Blocks protein domain: IPB007707 Transforming acidic coiled-coil-containing

    UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410
    Similarity: Belongs to the TACC family
    Similarity: Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains


    TACC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TACC1_HUMAN, O75410
    Function: Likely involved in the processes that promote cell division prior to the formation of differentiated
    tissues

         Genatlas biochemistry entry for TACC1:
    transforming acidic coiled-coil gene 1,highly expressed during early embryogenesis,potentially promoting
    tumorigenicity in breast cancers with amplification of the 8p11 region

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11903063
    GO:0019904protein domain specific binding IEA--
         
    TACC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TACC1:
     Decreased viability with carbo 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TACC1
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    miRNA
    Products:
        
    miRTarBase miRNAs that target TACC1:
    hsa-mir-193b-3p (MIRT016576), hsa-mir-148b-3p (MIRT043593), hsa-mir-342-3p (MIRT043739), hsa-mir-374b-5p (MIRT016082)

    Block miRNA regulation of human, mouse, rat TACC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TACC1 (see all 100):
    hsa-miR-4254 hsa-miR-199a-3p hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-374a hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TACC1

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TACC1 (NM_006283)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TACC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TACC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TACC1_HUMAN, O75410: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at
    the midbody during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    TACC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TACC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Aurora B signaling
    Aurora B signaling
    2Aurora A signaling
    Aurora A signaling


    2 BioSystems Pathways for TACC1
        Aurora A signaling
    Aurora B signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TACC1
    Interactions:

        GeneGlobe Interaction Network for TACC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TACC1 (O754101, 3 ENSP000003217034) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBQ96GD41, 3, ENSP000003139504EBI-624278,EBI-624291 I2D: score=4 STRING: ENSP00000313950
    SNRPGP623081, 3, ENSP000002723484EBI-624252,EBI-624585 I2D: score=4 STRING: ENSP00000272348
    TDRD7Q8NHU61, 3, ENSP000003474444EBI-624237,EBI-624505 I2D: score=4 STRING: ENSP00000347444
    CKAP5Q140081, 3, ENSP000003465664EBI-624237,EBI-310585 I2D: score=3 STRING: ENSP00000346566
    LSM7Q9UK451, 3, ENSP000002526224EBI-624252,EBI-348372 I2D: score=4 STRING: ENSP00000252622
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0007049cell cycle IEA--
    GO:0008283cell proliferation ----
    GO:0021987cerebral cortex development IEA--
    GO:0022008neurogenesis IEA--

    TACC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TACC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TACC1 gene (3 alternative transcripts): 
    NM_001122824.1  NM_001146216.2  NM_006283.2  

    Unigene Cluster for TACC1:

    Transforming, acidic coiled-coil containing protein 1
    Hs.279245  [show with all ESTs]
    Unigene Representative Sequence: CR933618
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000519416(uc011lby.1) ENST00000520615 ENST00000522474 ENST00000520340
    ENST00000522983 ENST00000518415 ENST00000521642(uc003xme.1 uc003xmd.1)
    ENST00000521050 ENST00000522904 ENST00000522752(uc010lwo.1) ENST00000524354
    ENST00000522544 ENST00000523239 ENST00000317827(uc003xmb.4 uc003xlz.3 uc003xmc.4 uc011lbz.2 uc010lwp.3 uc003xmf.4 uc011lcb.2 uc011lcd.2)
    ENST00000276520 ENST00000521528 ENST00000520973 ENST00000521935
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TACC1 (see all 100):
    hsa-miR-4254 hsa-miR-199a-3p hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-374a hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TACC1 (NM_006283)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TACC1
      QuantiTect SYBR Green Assays in human, mouse, rat TACC1
      QuantiFast Probe-based Assays in human, mouse, rat TACC1

    Additional mRNA sequence: 

    AB029026.1 AF049910.1 AF075051.1 AK057659.1 AK098223.1 AK124297.1 AK129750.1 AK294931.1 
    AK295071.1 AK295841.1 AK303596.1 AK304507.1 AK304725.1 AK304774.1 AK308849.1 AK314620.1 
    AY039239.1 AY072873.2 AY072874.1 AY072875.1 AY072876.2 AY139007.1 AY177411.1 BC041391.1 
    BX647696.1 CR933618.1 

    Selected DOTS entries (see all 25):

    DT.445878  DT.75170359  DT.95240638  DT.100797363  DT.100031422  DT.92006861  DT.40125901  DT.120636115 
    DT.100031423  DT.100010104  DT.100737639  DT.100797378  DT.120636076  DT.120636091  DT.120636160  DT.40233461 
    DT.95120300  DT.95222429  DT.100797361  DT.425248  DT.91680115  DT.100736149  DT.91955944  DT.95075498 

    Selected AceView cDNA sequences (see all 520):

    AA598796 AW029500 AA341700 AY072876 BQ888599 AI695820 AV717135 AW627696 
    AA745638 AW582870 BQ271606 AY072874 AY139007 AA287770 BQ007648 AI754006 
    AA933038 CA390222 BF438914 CB306860 CA396192 AA309567 AI085193 CB217090 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TACC1 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ·
    SP1:                                -     -           -     -                                               -                                         -     -   
    SP2:                                                  -     -                                               -                 -                       -     -   
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -                                         -     -   
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 16c ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20
    SP1:                    -     -               
    SP2:                    -     -               
    SP3:                    -     -               
    SP4:                    -     -               
    SP5:                    -     -               


    ECgene alternative splicing isoforms for TACC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TACC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCATTGCC
    TACC1 Expression
    About this image


    TACC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Coronary Vessels
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    TACC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TACC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279245

    UniProtKB/Swiss-Prot: TACC1_HUMAN, O75410
    Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the
    brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in
    normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of
    breast cancer

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TACC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TACC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tacc11 , 5 transforming, acidic coiled-coil containing protein more1, 5 80.16(n)1
    77.43(a)1
      8 (13.70 cM)5
    3201651  NM_177089.51  NP_796063.31 
     251545525 
    chicken
    (Gallus gallus)
    Aves TACC11 transforming, acidic coiled-coil containing protein more 69.05(n)
    68.93(a)
      431253  XM_428807.4  XP_428807.3 
    lizard
    (Anolis carolinensis)
    Reptilia TACC16
    transforming, acidic coiled-coil containing protei...
    50(a)
    1 ↔ 1
    GL343418.1(378766-454420)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58362 Transcribed sequence with weak similarity to protein more 74.64(n)    137722889 
    zebrafish
    (Danio rerio)
    Actinopterygii tacc11 transforming, acidic coiled-coil containing protein more 57.17(n)
    52.75(a)
      565711  XM_688981.6  XP_694073.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta tacc6
    transforming acidic coiled-coil protein
    10(a)
    1 → many
    3R(559376-574778)


    ENSEMBL Gene Tree for TACC1 (if available)
    TreeFam Gene Tree for TACC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TACC1 gene
    TACC32  TACC22  
    2 SIMAP similar genes for TACC1 using alignment to 14 protein entries:     TACC1_HUMAN (see all proteins):
    DKFZp686K18126    TACC2

    TACC1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TACC1
    PGOHUM00000238728 PGOHUM00000256607


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TACC1 (see all 2291)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810341321,2
    --38583729(+) CTCAAC/TAATCT 1 -- us2k10--------
    rs105435641,2
    C--38583846(+) TTTCT-/CTT   
      T
    /TTTC
    TTTCT
    1 -- us2k10--------
    rs1476368801,2
    C--38583846(+) TTTCT-/TTTC  
            
    TTTCT
    1 -- us2k10--------
    rs1862182021,2
    --38583939(+) GCAGCC/TTCGAT 1 -- us2k10--------
    rs1152540601,2
    F--38583945(+) TCGATC/TTCCCA 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1475820391,2
    --38584082(+) GAACTA/CCTGAA 1 -- us2k10--------
    rs1129891931,2
    C,F--38584115(+) GCCTCT/CGAAAG 1 -- us2k14Minor allele frequency- C:0.14WA NA CSA 126
    rs1417541181,2
    --38584116(+) CCTCTA/GAAAGT 1 -- us2k10--------
    rs1125076681,2
    C,F--38584123(+) AAGTGT/CTGGGA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1117458421,2
    C--38584166(+) AAACT-/ATTTT 
     TTCTTAC
    AATCT
    1 -- us2k11Minor allele frequency- ATTTTTTCTTAC:0.50CSA 2

    HapMap Linkage Disequilibrium report for TACC1 (38585704 - 38710546 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TACC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv396891CNV Insertion16902084
    nsv528721CNV Loss19592680
    esv25816CNV Loss19812545
    nsv831296CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TACC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TACC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605301    OMIM disorders: --

    12 diseases for TACC1:    
    About MalaCards
    gliosarcoma    giant cell glioblastoma    breast cancer    myeloproliferative disorder
    ovarian cancer    multiple myeloma    myeloma    prostate cancer
    cerebritis    prostatitis    adenocarcinoma    malaria


    TACC1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TACC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 46.3 10 18984771 (3), 10435627 (2), 16288026 (1), 12165861 (1) (see all 6)
    ovarian cancer 20.1 1 15918899 (1)
    tumors 19 10 15918899 (3), 16288026 (1), 18709641 (1), 17321332 (1) (see all 8)
    gastric cancer 19 3 12547166 (3)
    cancer 18.5 2 12165861 (1), 15918899 (1)

    Genetic Association Database (GAD): TACC1
    Human Genome Epidemiology (HuGE) Navigator: TACC1 (2 documents)

    Export disorders for TACC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TACC1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with TACC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. (PubMed id 12165861)1, 2, 9 Conte N.... Birnbaum D. (Oncogene 2002)
    2. Altered splicing pattern of TACC1 mRNA in gastric cancer. (PubMed id 12547166)1, 2, 9 Line A.... Rees R.C. (Cancer Genet. Cytogenet. 2002)
    3. Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. (PubMed id 10435627)1, 2, 9 Still I.H.... Cowell J.K. (Oncogene 1999)
    4. Aurora B -TACC1 protein complex in cytokinesis. (PubMed id 15064709)1, 2, 9 Delaval B.... Birnbaum D. (Oncogene 2004)
    5. TACC1-chTOG-Aurora A protein complex in breast cancer. (PubMed id 14603251)1, 2, 9 Conte N.... Birnbaum D. (Oncogene 2003)
    6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. (PubMed id 11903063)1, 2, 9 Lauffart B.... Still I.H. (Biochem. J. 2002)
    7. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. (PubMed id 11121038)1, 2, 9 Gergely F....Raff J.W. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    9. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. (PubMed id 21531210)1, 2 Gabillard J.C.... Arlot-Bonnemains Y. (Biochem. Biophys. Res. Commun. 2011)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6867 HGNC: 11522 AceView: TACC1 Ensembl:ENSG00000147526 euGenes: HUgn6867
    ECgene: TACC1 H-InvDB: TACC1

    (According to HUGE)
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    HUGE: KIAA1103

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TACC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TACC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TACC1 gene:
    Search GeneIP for patents involving TACC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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