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Aliases for TAC4 Gene

Aliases for TAC4 Gene

  • Tachykinin 4 (Hemokinin) 2 3 5
  • Preprotachykinin-C 3 4
  • PPT-C 3 4
  • Tachykinin-4 3
  • Endokinin 3
  • HK-1 3
  • HK1 3
  • EK 3

External Ids for TAC4 Gene

Previous GeneCards Identifiers for TAC4 Gene

  • GC17M050394
  • GC17M048263
  • GC17M048390
  • GC17M045270
  • GC17M047915
  • GC17M043280

Summaries for TAC4 Gene

Entrez Gene Summary for TAC4 Gene

  • This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAC4 Gene

TAC4 (Tachykinin 4 (Hemokinin)) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TAC4 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

Gene Wiki entry for TAC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC4 Gene

Genomics for TAC4 Gene

Regulatory Elements for TAC4 Gene

Enhancers for TAC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G049735 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.1 +104.8 104800 15.6 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 NXPH3 KAT7 ENSG00000230532 LOC105371824 SLC35B1 FLJ45513 TAC4 ENSG00000249406 COL1A1 LOC100288866
GH17G049814 1.7 Ensembl ENCODE dbSUPER 12.5 +30.8 30838 6.0 PKNOX1 CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZBTB7B FLJ45513 TAC4 ENSG00000235183 KAT7 FAM117A ENSG00000248172 DLX3 SLC35B1 PDK2 ENSG00000250282
GH17G049885 1.3 FANTOM5 ENCODE 13.7 -40.1 -40114 4.8 PKNOX1 MLX SIN3A ARID4B DMAP1 ZNF48 ZBTB7B YY1 ELK1 ZNF207 FLJ45513 DLX3 TAC4 DLX4 ENSG00000248172 RNU6-1313P SGCA ENSG00000253730 HILS1 RPL21P124
GH17G049722 1.3 Ensembl ENCODE dbSUPER 11.1 +124.2 124241 3.3 CTCF TFAP4 PKNOX1 ZSCAN4 SIN3A RAD21 YY1 POLR2A SCRT2 ZNF143 FLJ45513 TAC4 KAT7 FAM117A ENSG00000235183 SLC35B1 GC17P049768
GH17G049726 1.2 Ensembl ENCODE dbSUPER 11.1 +118.8 118807 5.1 BCOR ZMYM3 MAX RAD21 YY1 FOSL1 POLR2A NR2F6 FOS TRIM24 SPOP SLC35B1 ENSG00000250751 FAM117A KAT7 TAC4 FLJ45513 ENSG00000235183 DLX3 ENSG00000248172
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAC4 Gene

Chromosome:
17
Start:
49,838,309 bp from pter
End:
49,848,017 bp from pter
Size:
9,709 bases
Orientation:
Minus strand

Genomic View for TAC4 Gene

Genes around TAC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAC4 Gene

Proteins for TAC4 Gene

  • Protein details for TAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU9-TKN4_HUMAN
    Recommended name:
    Tachykinin-4
    Protein Accession:
    Q86UU9
    Secondary Accessions:
    • Q2M2P1
    • Q6ECK8
    • Q86UU6
    • Q86UU7
    • Q86UU8
    • Q8IWZ7

    Protein attributes for TAC4 Gene

    Size:
    113 amino acids
    Molecular mass:
    12305 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00843.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00844.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW94657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAC4 Gene

    Alternative splice isoforms for TAC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC4 Gene

Post-translational modifications for TAC4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TAC4 Gene

Domains & Families for TAC4 Gene

Gene Families for TAC4 Gene

Protein Domains for TAC4 Gene

Suggested Antigen Peptide Sequences for TAC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UU9

UniProtKB/Swiss-Prot:

TKN4_HUMAN :
  • Belongs to the tachykinin family.
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC4: view

Function for TAC4 Gene

Molecular function for TAC4 Gene

UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

Gene Ontology (GO) - Molecular Function for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with TAC4: view

Phenotypes for TAC4 Gene

GenomeRNAi human phenotypes for TAC4:
genes like me logo Genes that share phenotypes with TAC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TAC4

miRNA for TAC4 Gene

miRTarBase miRNAs that target TAC4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAC4 Gene

Localization for TAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAC4 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TAC4: view

Pathways & Interactions for TAC4 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with TAC4: view

Pathways by source for TAC4 Gene

1 BioSystems pathway for TAC4 Gene

Gene Ontology (GO) - Biological Process for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007217 tachykinin receptor signaling pathway IEA --
GO:0008217 regulation of blood pressure IEA --
GO:0046878 positive regulation of saliva secretion IEA --
genes like me logo Genes that share ontologies with TAC4: view

No data available for SIGNOR curated interactions for TAC4 Gene

Drugs & Compounds for TAC4 Gene

(1) Drugs for TAC4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TAC4: view

Transcripts for TAC4 Gene

mRNA/cDNA for TAC4 Gene

Unigene Clusters for TAC4 Gene

Tachykinin 4 (hemokinin):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TAC4 Gene

GeneLoc Exon Structure for
TAC4
ECgene alternative splicing isoforms for
TAC4

Expression for TAC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAC4 Gene

mRNA differential expression in normal tissues according to GTEx for TAC4 Gene

This gene is overexpressed in Pituitary (x12.1).

NURSA nuclear receptor signaling pathways regulating expression of TAC4 Gene:

TAC4

SOURCE GeneReport for Unigene cluster for TAC4 Gene:

Hs.652130

mRNA Expression by UniProt/SwissProt for TAC4 Gene:

Q86UU9-TKN4_HUMAN
Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.
genes like me logo Genes that share expression patterns with TAC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAC4 Gene

Orthologs for TAC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAC4 34 35
  • 98.58 (n)
dog
(Canis familiaris)
Mammalia TAC4 35
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tac4 35
  • 44 (a)
OneToOne
Species where no ortholog for TAC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAC4 Gene

ENSEMBL:
Gene Tree for TAC4 (if available)
TreeFam:
Gene Tree for TAC4 (if available)

Paralogs for TAC4 Gene

No data available for Paralogs for TAC4 Gene

Variants for TAC4 Gene

Sequence variations from dbSNP and Humsavar for TAC4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000363890 -- 49,841,025(+) CAGGC(A/C)CCTGC intron-variant
rs1000580865 -- 49,840,563(+) AGTGG(C/T)GTGAT intron-variant
rs1000778850 -- 49,846,990(+) CCTGC(C/T)GCCCT intron-variant, reference, synonymous-codon
rs1001020421 -- 49,842,842(+) TTTTT(C/T)AAAAA intron-variant
rs1001034785 -- 49,840,379(+) GAGCT(A/G)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAC4 Gene

Variant ID Type Subtype PubMed ID
esv25474 CNV loss 19812545
nsv819145 CNV loss 19587683
nsv821118 CNV duplication 20802225
nsv828037 CNV gain 20364138

Variation tolerance for TAC4 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC4 Gene

Disorders for TAC4 Gene

Relevant External Links for TAC4

Genetic Association Database (GAD)
TAC4
Human Genome Epidemiology (HuGE) Navigator
TAC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAC4

No disorders were found for TAC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAC4 Gene

Publications for TAC4 Gene

  1. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PMID: 12383518) Kurtz M.M. … Liu Q. (Gene 2002) 2 3 4 22 64
  2. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PMID: 17175032) Cunningham S. … Vandenbroeck K. (J. Neuroimmunol. 2007) 3 22 46 64
  3. Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PMID: 20580442) Klassert T.E. … HernA!ndez M. (J. Neuroimmunol. 2010) 3 46 64
  4. Regulatory mechanisms in the differential expression of Hemokinin-1. (PMID: 19081134) Tran A.H. … Paige C.J. (Neuropeptides 2009) 3 22 64
  5. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PMID: 17655832) Naono R. … Nishimori T. (Brain Res. 2007) 4 22 64

Products for TAC4 Gene

Sources for TAC4 Gene

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