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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAC4 Gene

protein-coding   GIFtS: 49
GCID: GC17M047915

Tachykinin 4 (Hemokinin)
  7 related diseases
at
MalaCards
 

Aliases
for TAC4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Tachykinin 4 (Hemokinin)1 2     endokinin2
PPT-C2 3     preprotachykinin-C2
EK2     tachykinin-42
HK-12     Preprotachykinin-C3
HK12     

External Ids:    HGNC: 166411   Entrez Gene: 2550612   Ensembl: ENSG000001763587   OMIM: 6078335   UniProtKB: Q86UU93   

Export aliases for TAC4 gene to outside databases

Previous GC identifers: GC17M050394 GC17M048263 GC17M048390 GC17M045270 GC17M043280


Summaries
for TAC4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TAC4 Gene:
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved
into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene
preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine
functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene
lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage
products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAC4 Gene: 
TAC4 (tachykinin 4 (hemokinin)) is a protein-coding gene. Diseases associated with TAC4 include ulcerative colitis, and crohn's disease, and among its related super-pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces
thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats.
These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and
increases sperm motility

summary for TAC4 Gene:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for TAC4 Gene


Genomic Views
for TAC4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAC4 gene promoter:
         Egr-3   AREB6   S8   AML1a   Sp1   HTF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

TAC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M047915:  view genomic region     (about GC identifiers)

Start:
 47,915,671 bp from pter      End:
 47,925,379 bp from pter
Size:
 9,709 bases      Orientation:
 minus strand

Proteins
for TAC4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 (See protein sequence)
Recommended Name: Tachykinin-4 precursor  
Size: 113 amino acids; 12305 Da
Subcellular location: Secreted (Probable)
Sequence caution: Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00843.1;
Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00844.1; Type=Miscellaneous discrepancy;
Note=Intron retention; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Sequence=EAW94657.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2M2P1 Q6ECK8 Q86UU6 Q86UU7 Q86UU8 Q8IWZ7
Alternative splicing: 5 isoforms:  Q86UU9-1   Q86UU9-2   Q86UU9-3   Q86UU9-4   Q86UU9-5   

Explore the universe of human proteins at neXtProt for TAC4: NX_Q86UU9

Explore proteomics data for TAC4 at MOPED 

TAC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TAC4 Protein Expression

REFSEQ proteins (5 alternative transcripts): 
NP_001070971.1  NP_001070972.1  NP_001070973.1  NP_001070974.1  NP_733786.2  

ENSEMBL proteins: 
 ENSP00000340461   ENSP00000334042   ENSP00000381221   ENSP00000399702   ENSP00000325286  
 ENSP00000421777  

Human Recombinant Protein Products for TAC4: 
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Cloud-Clone Corp. Proteins for TAC4 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

TAC4 for ontologies           About GeneDecksing



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Assay Products for TAC4: 
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Cloud-Clone Corp. CLIAs for TAC4

Protein Domains /
Families
for TAC4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 1 InterPro protein domain:
 IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry Q86UU9

ProtoNet protein and cluster: Q86UU9

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Similarity: Belongs to the tachykinin family


TAC4 for domains           About GeneDecksing


Function
for TAC4 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Molecular Function:

     UniProtKB/Swiss-Prot Summary: TKN4_HUMAN, Q86UU9
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces
thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats.
These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and
increases sperm motility

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding IEA--
     
TAC4 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tac4):
 cellular  hematopoietic system  immune system 

TAC4 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tac4tm1Albe for TAC4

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TAC4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAC4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAC4 
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miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate TAC4:
hsa-miR-892a
SwitchGear 3'UTR luciferase reporter plasmid: TAC4 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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                     Customized lentivirus expression plasmids for stable overexpression of TAC4 

Cell Line
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In Situ Assay
Products:   
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Pathways & Interactions
for TAC4 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TAC4 About                                                                                                See pathways by source

SuperPathContained pathways About
1Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
Peptide GPCRs0.46


1 BioSystems Pathway for TAC4
    Peptide GPCRs


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAC4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for TAC4 (Q86UU93 ENSP000003340424) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TACR2P214523, ENSP000003624034I2D: score=1 STRING: ENSP00000362403
TAC1P203663, ENSP000003211064I2D: score=1 STRING: ENSP00000321106
TACR1P251033, ENSP000003035224I2D: score=1 STRING: ENSP00000303522
TACR3P293713, ENSP000003033254I2D: score=1 STRING: ENSP00000303325
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007217tachykinin receptor signaling pathway IEA--
GO:0008217regulation of blood pressure IEA--
GO:0046878positive regulation of saliva secretion IEA--

TAC4 for ontologies           About GeneDecksing



Drugs & Compounds
for TAC4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TAC4 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for TAC4 available from Tocris Bioscience    About this table
CompoundAction CAS #
2-Deoxy-D-glucoseNon-metabolizable glucose analog; hexokinase substrate[154-17-6]
LonidamineMitochondrial hexokinase inhibitor[50264-69-2]

1 Novoseek inferred chemical compound relationship for TAC4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 0 2 15913794 (1), 12842130 (1)

Search CenterWatch for drugs/clinical trials and news about TAC4 / TKN4

Transcripts
for TAC4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for TAC4 gene (5 alternative transcripts): 
NM_001077503.1  NM_001077504.1  NM_001077505.1  NM_001077506.1  NM_170685.2  

Unigene Cluster for TAC4:

Tachykinin 4 (hemokinin)
Hs.652130  [show with all ESTs]
Unigene Representative Sequence: AF515828
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000352793(uc002ips.1 uc002ipt.3) ENST00000334568(uc002ipo.1 uc002ipu.3)
ENST00000398154(uc002ipr.1) ENST00000436235(uc002ipp.1) ENST00000326219(uc002ipq.1)
ENST00000503603
miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate TAC4:
hsa-miR-892a
SwitchGear 3'UTR luciferase reporter plasmid: TAC4 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TAC4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC4
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC4
Sirion Biotech Customized lentivirus for stable overexpression of TAC4 
                     Customized lentivirus expression plasmids for stable overexpression of TAC4 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC4

Additional mRNA sequence: 

AF515828.1 AF515829.1 AF515830.1 AF515831.1 AY471574.1 BC100840.2 BC100841.1 BC100842.2 
BC100843.2 

6 DOTS entries:

DT.100746269  DT.100001553  DT.100746267  DT.120919236  DT.101969251  DT.91989114 

10 AceView cDNA sequences:

NM_170685 AF521560 AF515830 AF515829 AF515831 AY471574 AF515828 BF837128 
BF840399 BF840431 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TAC4    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:        -                           
SP2:                                    
SP3:        -           -               
SP4:        -           -     -         


ECgene alternative splicing isoforms for TAC4

Expression
for TAC4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAC4 expression in normal human tissues (normalized intensities)      TAC4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGAAGCGAG
TAC4 Expression
About this image


TAC4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...

See TAC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAC4

SOURCE GeneReport for Unigene cluster: Hs.652130

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is
found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate,
adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta

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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC4

Orthologs
for TAC4 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for TAC4 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Tac45 tachykinin 4   --   11 (59.01 cM) 95261529 


ENSEMBL Gene Tree for TAC4 (if available)
TreeFam Gene Tree for TAC4 (if available)

Paralogs
for TAC4 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for TAC4 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/241 SNPs in TAC4 are shown (see all 241)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 17 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs669392091,2
C--43285888(+) GTGCT-/CCCCAT 5 -- int10--------
rs112970591,2
C--43288650(+) CCTCA-/TTTTTT 5 -- int1 trp32Minor allele frequency- T:0.00NA CSA 4
rs1381902261,2
--48928735(+) GGCTTC/TAGAGG 5 -- ds50010--------
rs1497464171,2
C--48928952(+) GTGAG-/GCCGCCAC 5 -- cds10--------
rs1150702951,2
C--48928974(+) CAGAGC/GCCAGG 5 -- ds50010--------
rs1814678921,2
--48929065(+) CACAGG/TATACA 5 -- ut310--------
rs1865040231,2
--48929152(+) TGCTAC/TGGCGA 5 -- ut310--------
rs1909242631,2
C--48929310(+) ATCCAC/GGTAGG 5 -- ut310--------
rs616257691,2
C,F--48929315(+) GGTAGG/CAAGAA 5 -- ut311Minor allele frequency- C:0.14EA 120
rs2007844901,2
--48929322(+) AGAAGC/TGGCAC 5 -- ut310--------

HapMap Linkage Disequilibrium report for TAC4 (47915671 - 47925379 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TAC4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv821118CNV Duplication20802225
esv25474CNV Loss19812545
nsv819145CNV Loss19587683
nsv828037CNV Gain20364138

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAC4
DNA2.0 Custom Variant and Variant Library Synthesis for TAC4

Disorders / Diseases
for TAC4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
 OMIM gene information: 607833    OMIM disorders: --

7 diseases for TAC4:    About MalaCards
ulcerative colitis    crohn's disease    astrocytoma    multiple sclerosis
asthma    neuronitis    prostatitis

1 disease from the University of Copenhagen DISEASES database for TAC4:
Shipyard eye

TAC4 for disorders           About GeneDecksing

Genetic Association Database (GAD): TAC4
Human Genome Epidemiology (HuGE) Navigator: TAC4 (2 documents)

Export disorders for TAC4 gene to outside databases

Publications
for TAC4 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TAC4 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with TAC4)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PubMed id 12383518)1, 2, 3, 9 Kurtz M.M.... Liu Q. (2002)
  2. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032)1, 4, 9 Cunningham S....Vandenbroeck K. (2007)
  3. Common variants of the neuropeptide expressing tachyk inin genes and susceptibility to asthma: a case-control study. (PubMed id 20580442)1, 4 Klassert T.E....HernA!ndez M. (2010)
  4. Characterization of the endokinins: human tachykinins with cardiovascular activity. (PubMed id 12716968)1, 2 Page N.M.... Lowry P.J. (2003)
  5. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. (PubMed id 11062498)1, 3 Zhang Y....Paige C.J. (2000)
  6. Regulatory mechanisms in the differential expression of Hemokinin-1. (PubMed id 19081134)1, 9 Tran A.H....Paige C.J. (2009)
  7. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PubMed id 17655832)2, 9 Naono R.... Nishimori T. (2007)
  8. Hemokinins and endokinins. (PubMed id 15224188)1, 9 Page N.M. (2004)
  9. A role for tachykinins in the regulation of human sperm motility. (PubMed id 17437961)2, 9 Ravina C.G....Candenas M.L. (2007)
  10. Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides. (PubMed id 16931167)1, 9 Page N.M. (2006)

External Searches for TAC4 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing TAC4 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 255061 HGNC: 16641 AceView: TAC4 Ensembl:ENSG00000176358 euGenes: HUgn255061
ECgene: TAC4 H-InvDB: TAC4

Other Databases showing TAC4 gene

(According to HUGE)
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Specialized Databases showing TAC4 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TAC4 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for TAC4 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TAC4 gene:
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