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TAC4 Gene

protein-coding   GIFtS: 43

GC17M045270
tachykinin 4 (hemokinin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EK 2
HK-1 1, 2
MGC133009 2
MGC133010 2
PPT-C 1, 2, 3
Pptc 1
Preprotachykinin-C 3
endokinin 2
hemokinin 2
Descriptions
preprotachykinin C 2
tachykinin 4 2
tachykinin 4 (hemokinin) 2
External Ids
HGNC: 166411
Entrez Gene: 2550612
UniProtKB: Q86UU93
Ensembl: ENSG000001763587
Search outside databases for aliases for TAC4 gene

Previous GC identifers: GC17M050394 GC17M048263 GC17M048390

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAC4:
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin
proteins are cleaved into small, secreted peptides that activate members of a family of receptor
proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought
to regulate peripheral endocrine and paracrine functions including blood pressure, the immune
system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site
found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in
vivo remains to be determined. Multiple transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are
potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following
intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C.
Endokinin-A/B reduces arterial blood pressure and increases sperm motility

Gene Wiki entry for TAC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAC4 gene  

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

TAC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M045270:     (about GC identifiers)

Start:
45,270,670 bp from pter
End:
45,280,378 bp from pter
Size:
9,709 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 (See protein sequence)
Recommended Name: Tachykinin-4 precursor  
Size: 113 amino acids; 12305 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q2M2P1 Q6ECK8 Q86UU6 Q86UU7 Q86UU8 Q8IWZ7
Alternative splicing: 7 isoforms:  Q86UU9-1   Q86UU9-2   Q86UU9-3   Q86UU9-4   Q86UU9-5   Q86UU9-6   Q86UU9-7   

REFSEQ proteins (5 alternative transcripts): 
NP_001070971.1  NP_001070972.1  NP_001070973.1  NP_001070974.1  NP_733786.2  


ENSEMBL proteins: 
ENSP00000340461 ENSP00000325286 ENSP00000381221 ENSP00000334042 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for TAC4  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for TAC4: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for TAC4

Assays for TAC4: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR013055 Tachy_Neuro_lke_CS


   GeneDecks  TAC4 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q86UU9

ProtoNet protein and cluster: Q86UU9

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Similarity: Belongs to the tachykinin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_170685

              Applied Biosystems Silencer® siRNAs for TAC4

              Sigma-Aldrich siRNA for TAC4  
                     Sigma-Aldrich shRNA for TAC4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001077503
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001077503
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001077503 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_170685

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are
potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following
intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C.
Endokinin-A/B reduces arterial blood pressure and increases sperm motility

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005102 receptor binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/11 Interacting proteins for TAC4 (ENSP000003340423) via UniProtKB, MINT, and/or STRING (see all 11 )
InteractantInteraction Details
GeneCardExternal ID(s)
TACR1ENSP000003035223STRING (score=.976)
TACR2ENSP000003624033STRING (score=.964)
TACR3ENSP000003033253STRING (score=.956)
TAC1ENSP000003211063STRING (score=.923)
SFRS12ENSP000003345383STRING (score=.883)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007217 tachykinin receptor signaling pathway IEA--
GO:0008217 regulation of blood pressure IEA--
GO:0046878 positive regulation of saliva secretion IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAC4
1 Novoseek chemical compound relationship for TAC4 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 0.00 2 15913794 (1), 12842130 (1)
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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_170685

              Sigma-Aldrich siRNA for TAC4  
                     Sigma-Aldrich shRNA for TAC4  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001077503  NM_001077504  NM_001077505  NM_001077506  NM_170685  

REFSEQ mRNAs for TAC4 gene (5 alternative transcripts): 

NM_001077503.1   NM_001077504.1   NM_001077505.1   NM_001077506.1   NM_170685.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001077503  NM_001077504  NM_001077505  NM_001077506  NM_170685  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001077503
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001077503
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001077503 

Additional cDNA sequence: 

AF515828.1 AF515829.1 AF515830.1 AF515831.1 AY471574.1 BC100840.2 BC100842.2 BC100843.2 

6 DOTS entries:

DT.101969251  DT.100746269  DT.100001553  DT.100746267  DT.120919236  DT.91989114 

10 AceView cDNA sequences:

AF515830 AF515831 NM_170685 AF521560 AF515828 AF515829 AY471574 BF837128 
BF840399 BF840431 

highest scoring ESTs for TAC4:

AF515828 AF515829 AF515830 AF515831 AF521560 AY471574 BC100840 BC100841 BC100842 BC100843 

Unigene Clusters for TAC4:

Tachykinin 4 (hemokinin)
Hs.434138  [show with all ESTs], Hs.652130  [show with all ESTs]
Unigene Representative Sequences: XM_001133597, AF515828


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TAC4

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:        -                           
SP2:                                    
SP3:        -           -               
SP4:        -           -     -         

About this scheme

ECgene alternative splicing isoforms for TAC4

4 Ensembl transcripts including schematic representations:
ENST00000352793  ENST00000326219  ENST00000398154  ENST00000334568  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAC4 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TAC4

1 / 2

1 probe-set matching TAC4 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1553094_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.434138 Hs.652130

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9
Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women.
Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver,
bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed
predominantly in adrenal gland and placenta. Isoform 6 is widely expressed with high levels in
skin

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TAC4 gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
TAC41   -- tachykinin 4 (hemokinin) 98.53(n)
96.46(a)
746809  XM_001168519.1  XP_001168519.1 
mouse
(Mus musculus)
Tac45 11 tachykinin 4   -- BC119426 
About this table        Species with no ortholog for TAC4

ENSEMBL Gene Tree for TAC4
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/21 NCBI SNPs in TAC4 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 15)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs4125211,2
H45281730(+) tcaggT/Ggatct 5 -- ng314Minor allele frequency- G:0.00EU EA WA 418
rs4331851,2
H45281845(+) TGGTAG/AAAAAT 5 -- ng314Minor allele frequency- A:0.00EU EA WA 416
--
rs4375831,2
H45281848(+) TAAAAG/AATGAG 5 -- ng314Minor allele frequency- A:0.00EU EA WA 398
rs8830101,2
A,C,F,H,O45271796(-) TCAACA/CACTGT 5 -- int116Minor allele frequency- C:0.26EU EA WA NA 1474
rs118677901,2
H45273653(+) TAAGGT/GAATTT 5 -- int14Minor allele frequency- G:0.00EU EA WA 404
rs99053461,2
H45275670(+) GGACTC/TCTGAG 5 -- int14Minor allele frequency- T:0.00EU EA WA 356
--
rs616257691,2
--45270958(+) GGTAGC/GAAGAA 5 -- ut310--------
--
rs346055821,2
--45270454(+) CCCAT-/CCCCGT 5 -- ng510--------
rs4275251,2
--45281857(+) AGTAAA/GACATT 5 -- ng310--------
--
rs598640011,2
--45271005(+) CTTTTA/CCTCTG 5 X/E mis10--------
About this table

HapMap Linkage Disequilibrium images for TAC4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607833

Human Genome Epidemiology Navigator: TAC4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/20 PubMed articles for TAC4 gene (see all 20 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 255061 HGNC: 16641 AceView: TAC4 Ensembl:ENSG00000176358 euGenes: HUgn255061
ECgene: TAC4 H-InvDB: TAC4
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TAC4:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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