Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TAC4 Gene

protein-coding GIFtS: 49
GCID: GC17M047915

tachykinin 4 (hemokinin)

Explore 7 diseases affiliated with
TAC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tachykinin 4 (Hemokinin)¹ ²		HK1²
PPT-C¹ ² ³		Endokinin¹
HK-1¹ ²		Preprotachykinin-C³
Pptc¹		Tachykinin-4¹
EK²		Preprotachykinin-C³

External Ids:	HGNC: 16641¹	Entrez Gene: 255061²	Ensembl: ENSG00000176358⁷	OMIM: 607833⁵	UniProtKB: Q86UU9³

Export aliases for TAC4 gene to outside databases

Previous GC identifers: GC17M050394 GC17M048263 GC17M048390 GC17M045270 GC17M043280

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAC4:

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into

small, secreted peptides that activate members of a family of receptor proteins. The products of this gene

preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine

functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a

dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated

in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and

pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by

treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility

summary for TAC4:

Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose

into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial

oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which

has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer

mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as

skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation

and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose

metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for TAC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TAC4 gene promoter:
Egr-3 AREB6 S8 AML1a Sp1 HTF RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAC4 promoter sequence

Search SABiosciences Chromatin IP Primers for TAC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33

TAC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M047915: view genomic region (about GC identifiers)

Start:	47,915,671 bp from pter	End:	47,925,379 bp from pter
Size:	9,709 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 (See protein sequence)

Recommended Name: Tachykinin-4 precursor

Size: 113 amino acids; 12305 Da

Subcellular location: Secreted (Probable)

Sequence caution: Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00843.1;

Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00844.1; Type=Miscellaneous discrepancy;

Note=Intron retention; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Sequence=EAW94657.1; Type=Erroneous gene model prediction;

Secondary accessions: Q2M2P1 Q6ECK8 Q86UU6 Q86UU7 Q86UU8 Q8IWZ7

Alternative splicing: 5 isoforms: Q86UU9-1 Q86UU9-2 Q86UU9-3 Q86UU9-4 Q86UU9-5

Explore the universe of human proteins at neXtProt for TAC4: NX_Q86UU9

TAC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001070971.1 NP_001070972.1 NP_001070973.1 NP_001070974.1 NP_733786.2

ENSEMBL proteins:

ENSP00000340461 ENSP00000334042 ENSP00000381221 ENSP00000399702 ENSP00000325286

ENSP00000421777

Human Recombinant Protein Products for TAC4:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TAC4 OriGene Custom Protein Services for TAC4
	GenScript Custom Purified and Recombinant Proteins Services for TAC4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TAC4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

TAC4 for ontologies About GeneDecksing

TAC4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TAC4
	GenScript Custom Superior Antibodies Services for TAC4
	Abcam antibodies for TAC4
	Uscn Antibodies for TAC4
	Search ThermoFisher Antibodies for TAC4

Assay Products for TAC4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TAC4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TAC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAC4 for domains About GeneDecksing

1 InterPro domain/family:

IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry Q86UU9

ProtoNet protein and cluster: Q86UU9

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9

Similarity: Belongs to the tachykinin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TKN4_HUMAN, Q86UU9

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and

pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by

treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--

TAC4 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tac4):

cellular

hematopoietic system

immune system

TAC4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tac4^tm1Albe for TAC4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TAC4

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAC4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TAC4:
		hsa-miR-892a
		SwitchGear 3'UTR luciferase reporter plasmid: TAC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC4 (see all 7) OriGene shRNA RFP: TAC4 OriGene siRNA: TAC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC4
		Sirion Biotech Custom design and validation of potent shRNA sequences against TAC4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TAC4
			Sirion Biotech Customized adenovirus for overexpression of TAC4 Sirion Biotech Customized adenovirus for potent knockdown of TAC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TAC4 (NM_170685)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TAC4
		Search LifeMap BioReagents cell lines for TAC4
		Sirion Biotech Customized stable knockdown cell line services for TAC4 Sirion Biotech Customized inducible knockdown cell line services for TAC4 Sirion Biotech Customized stable overexpressing cell line services for TAC4 Sirion Biotech Customized inducible overexpressing cell line services for TAC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Peptide GPCRs

0.46

1 BioSystems Pathway for TAC4

Peptide GPCRs

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TAC4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for TAC4 (Q86UU9³ ENSP00000334042⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TACR2	P21452³, ENSP00000362403⁴	I2D: score=1 STRING: ENSP00000362403
TAC1	P20366³, ENSP00000321106⁴	I2D: score=1 STRING: ENSP00000321106
TACR1	P25103³, ENSP00000303522⁴	I2D: score=1 STRING: ENSP00000303522
TACR3	P29371³, ENSP00000303325⁴	I2D: score=1 STRING: ENSP00000303325

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007217	tachykinin receptor signaling pathway	IEA	--
GO:0008217	regulation of blood pressure	IEA	--
GO:0046878	positive regulation of saliva secretion	IEA	--

TAC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TAC4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TAC4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Lonidamine	Mitochondrial hexokinase inhibitor	[50264-69-2]

1 Novoseek chemical compound relationship for TAC4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	0	2	15913794 (1), 12842130 (1)

Search CenterWatch for drugs/clinical trials and news about TAC4 / TKN4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAC4 gene (5 alternative transcripts):

NM_001077503.1 NM_001077504.1 NM_001077505.1 NM_001077506.1 NM_170685.2

Unigene Cluster for TAC4:

Tachykinin 4 (hemokinin)

Hs.652130 [show with all ESTs]

Unigene Representative Sequence: AF515828

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000352793(uc002ips.1 uc002ipt.3) ENST00000334568(uc002ipo.1 uc002ipu.3)

ENST00000398154(uc002ipr.1) ENST00000436235(uc002ipp.1) ENST00000326219(uc002ipq.1)

ENST00000503603

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAC4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TAC4:
		hsa-miR-892a
		SwitchGear 3'UTR luciferase reporter plasmid: TAC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC4 (see all 7) OriGene shRNA RFP: TAC4 OriGene siRNA: TAC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC4
		Sirion Biotech Custom design and validation of potent shRNA sequences against TAC4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TAC4 (NM_170685)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat TAC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC4

Additional cDNA sequence:

AF515828.1 AF515829.1 AF515830.1 AF515831.1 AY471574.1 BC100840.2 BC100841.1 BC100842.2

BC100843.2

6 DOTS entries:

DT.100746269 DT.100001553 DT.100746267 DT.120919236 DT.101969251 DT.91989114

10 AceView cDNA sequences:

NM_170685 AF515829 AF515830 AY471574 AF515828 AF515831 AF521560 BF837128

BF840399 BF840431

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TAC4 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5
SP1:			-
SP2:
SP3:			-				-
SP4:			-				-		-

ECgene alternative splicing isoforms for TAC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAGCGAG

About this image

TAC4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TAC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAC4

SOURCE GeneReport for Unigene cluster: Hs.652130

UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9

Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found

only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland

and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta

SABiosciences Custom PCR Arrays for TAC4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat TAC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TAC4 gene from 1/2 species (see all 2) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tac4⁵	tachykinin 4	--		11 (59.01 cM) 95261529

ENSEMBL Gene Tree for TAC4 (if available)
TreeFam Gene Tree for TAC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75424427^1,2	F	--	43281135(+)	`GAAGGC/GCTTCA`	5	--	int¹		1		WA	118
rs112615257^1,2		--	43281270(+)	`ACCCTG/CTTTAA`	5	--	int¹		1		CSA	2
rs112361308^1,2	C	--	43281425(+)	`TGACTC/TCTAGT`	5	--	int¹		1		NA	2
rs77014095^1,2	F	--	43281426(+)	`GACTCC/ATAGTA`	5	--	int¹		1		NA	120
rs78376897^1,2		--	43281455(+)	`ATGGAA/GGAACA`	5	--	int¹		0	--	--	--	--
rs73337039^1,2	C	--	43281647(+)	`TGCCCG/ACTCAC`	5	--	int¹		2		WA	120
rs112866703^1,2	C	--	43282445(+)	`ACACCG/ATGGAC`	5	--	int¹		1		NA	2
rs34931154^1,2		--	43282967(+)	`CTCCCA/GGGTTC`	5	--	int¹		0	--	--	--	--
rs11867790^1,2	C,H	--	43283663(+)	`TAAGGT/GAATTT`	5	--	int¹		5		NS EA NA	406
rs75538962^1,2		--	43283720(+)	`GCAGCC/TGCTCC`	5	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for TAC4 (47915671 - 47925379 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TAC4
2 CNVs: 58798 67219

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAC4

DNA2.0 Custom Variant and Variant Library Synthesis for TAC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAC4 for disorders           About GeneDecksing

OMIM gene information: 607833    OMIM disorders: --

7 diseases for TAC4:    About MalaCards

ulcerative colitis multiple sclerosis crohn's disease astrocytoma

asthma prostatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: TAC4 (2 documents)

Export disorders for TAC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TAC4 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with TAC4)

Utopia: connect your pdf to the dynamic
world of online information

Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PubMed id 12383518)^{1, 2, 3, 9} Kurtz M.M.... Liu Q. (2002)
Characterization of the endokinins: human tachykinins with cardiovascular activity. (PubMed id 12716968)^{1, 2} Page N.M.... Lowry P.J. (2003)
Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. (PubMed id 11062498)^{1, 3} Zhang Y....Paige C.J. (2000)
Regulatory mechanisms in the differential expression of Hemokinin-1. (PubMed id 19081134)^{1, 9} Tran A.H....Paige C.J. (2009)
Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PubMed id 17655832)^{2, 9} Naono R.... Nishimori T. (2007)
The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032)^{1, 9} Cunningham S....Vandenbroeck K. (2007)
Hemokinins and endokinins. (PubMed id 15224188)^{1, 9} Page N.M. (2004)
A role for tachykinins in the regulation of human sperm motility. (PubMed id 17437961)^{2, 9} Ravina C.G....Candenas M.L. (2007)
Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides. (PubMed id 16931167)^{1, 9} Page N.M. (2006)
Tachykinins and tachykinin receptors in human uterus. (PubMed id 12788812)^{2, 9} Patak E.... Pinto F.M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255061	HGNC: 16641	AceView: TAC4	Ensembl:ENSG00000176358	euGenes: HUgn255061
ECgene: TAC4	H-InvDB: TAC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TAC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TAC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TAC4 gene:
Search GeneIP for patents involving TAC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TAC4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC4
	OriGene Protein Over-expression Lysate for TAC4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TAC4		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TAC4		OriGene Custom Protein Services for TAC4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAC4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAC4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC4

	GenScript Custom Purified and Recombinant Proteins Services for TAC4		GenScript cDNA clones with any tag delivered in your preferred vector for TAC4
	GenScript Custom Assay Services for TAC4		GenScript Custom Superior Antibodies Services for TAC4
	GenScript Custom overexpressing Cell Line Services for TAC4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TAC4 promoter
	Search Chromatin IP Primers for TAC4
	RT² qPCR Primer Assay in human, mouse / rat TAC4
	Search GNC Networks for TAC4
	SABiosciences Custom PCR Arrays for TAC4

Tocris compounds for TAC4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Antibodies for TAC4
	See all of Abcam's Antibodies, Kits and Proteins for TAC4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TAC4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TAC4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC4

	SwitchGear 3'UTR luciferase reporter plasmids for TAC4
	SwitchGear Promoter luciferase reporter plasmids for TAC4

Search ThermoFisher Antibodies for TAC4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TAC4

Sirion Biotech Customized:

	stable knockdown cell line services for TAC4
	inducible knockdown cell line services for TAC4
	design and validation of potent shRNA sequences against TAC4
	adenovirus for potent knockdown of TAC4
	adenovirus for overexpression of TAC4
	stable overexpressing cell line services for TAC4
	inducible overexpressing cell line services for TAC4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TAC4 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TAC4 Gene

tachykinin 4 (hemokinin)

Aliases
for TAC4 gene

Summaries
for TAC4 gene

Genomic Views
for TAC4 gene

Proteins
for TAC4 gene

Protein Domains /
Families
for TAC4 gene

Function
for TAC4 gene

Pathways & Interactions
for TAC4 gene

Drugs & Compounds
for TAC4 gene

Transcripts
for TAC4 gene

Expression
for TAC4 gene

Orthologs
for TAC4 gene

Paralogs
for TAC4 gene

Genomic Variants
for TAC4 gene

Disorders / Diseases
for TAC4 gene

Publications
for TAC4 gene

External Searches for TAC4 gene

Genome Databases showing TAC4 gene

Other Databases showing TAC4 gene

Specialized Databases showing TAC4 gene

Intellectual Property
for TAC4 gene

Products
for TAC4 gene

View Random Gene

Advanced Search

Export list of displayed genes

TAC4 Gene

tachykinin 4 (hemokinin)

Aliasesfor TAC4 gene

Summariesfor TAC4 gene

Genomic Viewsfor TAC4 gene

Proteinsfor TAC4 gene

Protein Domains /Familiesfor TAC4 gene

Functionfor TAC4 gene

Pathways & Interactionsfor TAC4 gene

Drugs & Compoundsfor TAC4 gene

Transcriptsfor TAC4 gene

Expression for TAC4 gene

Orthologsfor TAC4 gene

Paralogsfor TAC4 gene

Genomic Variantsfor TAC4 gene

Disorders / Diseasesfor TAC4 gene

Publicationsfor TAC4 gene

External Searches for TAC4 gene

Genome Databases showing TAC4 gene

Other Databases showing TAC4 gene

Specialized Databases showing TAC4 gene

Intellectual Propertyfor TAC4 gene

Productsfor TAC4 gene

View Random Gene

Aliases
for TAC4 gene

Summaries
for TAC4 gene

Genomic Views
for TAC4 gene

Proteins
for TAC4 gene

Protein Domains /
Families
for TAC4 gene

Function
for TAC4 gene

Pathways & Interactions
for TAC4 gene

Drugs & Compounds
for TAC4 gene

Transcripts
for TAC4 gene

Expression
for TAC4 gene

Orthologs
for TAC4 gene

Paralogs
for TAC4 gene

Genomic Variants
for TAC4 gene

Disorders / Diseases
for TAC4 gene

Publications
for TAC4 gene

Intellectual Property
for TAC4 gene

Products
for TAC4 gene