Aliases for TAC4 Gene
Aliases for TAC4 Gene
External Ids for TAC4 Gene
- HGNC: 16641
- Entrez Gene: 255061
- Ensembl: ENSG00000176358
- OMIM: 607833
- UniProtKB: Q86UU9
Previous GeneCards Identifiers for TAC4 Gene
- GC17M050394
- GC17M048263
- GC17M048390
- GC17M045270
- GC17M047915
- GC17M043280
Summaries for TAC4 Gene
-
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAC4 Gene
TAC4 (Tachykinin 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for TAC4 Gene
-
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC4 Gene
Genomics for TAC4 Gene
GeneHancer (GH) Regulatory Elements for TAC4 Gene
Regulatory Element Products
Genomic Locations for TAC4 Gene
- chr17:49,838,309-49,848,017
- (GRCh38/hg38)
- Size:
- 9,709 bases
- Orientation:
- Minus strand
- chr17:47,915,671-47,925,379
- (GRCh37/hg19)
Genomic View for TAC4 Gene
- Cytogenetic band:
-
- 17q21.33 by Ensembl
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC


RefSeq DNA sequence for TAC4 Gene
Proteins for TAC4 Gene
-
Protein details for TAC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU9-TKN4_HUMAN
- Recommended name:
- Tachykinin-4
- Protein Accession:
- Q86UU9
- Q2M2P1
- Q6ECK8
- Q86UU6
- Q86UU7
- Q86UU8
- Q8IWZ7
Protein attributes for TAC4 Gene
- Size:
- 113 amino acids
- Molecular mass:
- 12305 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00843.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00844.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW94657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for TAC4 Gene
Other Protein References for TAC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
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No data available for DME Specific Peptides for TAC4 Gene
Domains & Families for TAC4 Gene
Gene Families for TAC4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for TAC4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UU9- Family:
-
- Belongs to the tachykinin family.
Function for TAC4 Gene
Molecular function for TAC4 Gene
- UniProtKB/Swiss-Prot Function:
- Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
Phenotypes From GWAS Catalog for TAC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | receptor binding | IBA | -- |
Phenotypes for TAC4 Gene
- GenomeRNAi human phenotypes for TAC4:
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAC4 Gene
Localization for TAC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAC4 Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA,IBA | 17437961 |
GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAC4 Gene
Pathways & Interactions for TAC4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
Pathways by source for TAC4 Gene
1 BioSystems pathway for TAC4 Gene
Interacting Proteins for TAC4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | IBA | -- |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IBA | -- |
GO:0007217 | tachykinin receptor signaling pathway | IBA,IEA | -- |
GO:0007267 | cell-cell signaling | IBA | -- |
GO:0008217 | regulation of blood pressure | IEA | -- |
No data available for SIGNOR curated interactions for TAC4 Gene
Transcripts for TAC4 Gene
mRNA/cDNA for TAC4 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TAC4 Gene
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-
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ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: | |||||||||||
SP3: | - | - | |||||||||
SP4: | - | - | - |
Expression for TAC4 Gene
mRNA differential expression in normal tissues according to GTEx for TAC4 Gene
NURSA nuclear receptor signaling pathways regulating expression of TAC4 Gene:
TAC4SOURCE GeneReport for Unigene cluster for TAC4 Gene:
Hs.652130mRNA Expression by UniProt/SwissProt for TAC4 Gene:
Q86UU9-TKN4_HUMANPrimer Products
-
OriGene qPCR primer pairs for TAC4
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAC4 Gene
Orthologs for TAC4 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TAC4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TAC4 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Tac4 34 |
|
OneToOne |
- Species where no ortholog for TAC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TAC4 Gene
No data available for Paralogs for TAC4 Gene
Variants for TAC4 Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000363890 | -- | 49,841,025(-) | A/C | intron_variant | |
rs1000580865 | -- | 49,840,563(-) | C/T | intron_variant | |
rs1000778850 | -- | 49,846,990(-) | T/A/C | intron_variant | |
rs1001020421 | -- | 49,842,842(-) | T/C | intron_variant | |
rs1001034785 | -- | 49,840,379(-) | G/A | intron_variant |
Additional Variant Information for TAC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC4 Gene
Disorders for TAC4 Gene
Additional Disease Information for TAC4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TAC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAC4 Gene
Publications for TAC4 Gene
- Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PMID: 12383518) Kurtz MM … Liu Q (Gene 2002) 2 3 4 22 58
- The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PMID: 17175032) Cunningham S … Vandenbroeck K (Journal of neuroimmunology 2007) 3 22 44 58
- A role for tachykinins in the regulation of human sperm motility. (PMID: 17437961) Ravina CG … Candenas ML (Human reproduction (Oxford, England) 2007) 3 4 22 58
- Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PMID: 20580442) Klassert TE … Hernández M (Journal of neuroimmunology 2010) 3 44 58
- Regulatory mechanisms in the differential expression of Hemokinin-1. (PMID: 19081134) Tran AH … Paige CJ (Neuropeptides 2009) 3 22 58
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 19 available TAC4 Antibodies ranked by validation data
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Sources for TAC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
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