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Aliases for TAC4 Gene

Aliases for TAC4 Gene

  • Tachykinin 4 (Hemokinin) 2 3
  • Preprotachykinin-C 3 4
  • PPT-C 3 4
  • HK1 3 6
  • Tachykinin-4 3
  • Endokinin 3
  • HK-1 3
  • RAC4 6
  • PPTC 6
  • EK 3

External Ids for TAC4 Gene

Previous GeneCards Identifiers for TAC4 Gene

  • GC17M050394
  • GC17M048263
  • GC17M048390
  • GC17M045270
  • GC17M047915
  • GC17M043280

Summaries for TAC4 Gene

Entrez Gene Summary for TAC4 Gene

  • This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAC4 Gene

TAC4 (Tachykinin 4 (Hemokinin)) is a Protein Coding gene. Diseases associated with TAC4 include shipyard eye. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TAC4 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

Gene Wiki entry for TAC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC4 Gene

Genomics for TAC4 Gene

Regulatory Elements for TAC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAC4 Gene

Start:
49,838,309 bp from pter
End:
49,848,017 bp from pter
Size:
9,709 bases
Orientation:
Minus strand

Genomic View for TAC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAC4 Gene

Proteins for TAC4 Gene

  • Protein details for TAC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU9-TKN4_HUMAN
    Recommended name:
    Tachykinin-4
    Protein Accession:
    Q86UU9
    Secondary Accessions:
    • Q2M2P1
    • Q6ECK8
    • Q86UU6
    • Q86UU7
    • Q86UU8
    • Q8IWZ7

    Protein attributes for TAC4 Gene

    Size:
    113 amino acids
    Molecular mass:
    12305 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00843.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00844.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW94657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TAC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC4 Gene

Proteomics data for TAC4 Gene at MOPED

Post-translational modifications for TAC4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TAC4 Gene

Domains for TAC4 Gene

Gene Families for TAC4 Gene

HGNC:

Protein Domains for TAC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UU9

UniProtKB/Swiss-Prot:

TKN4_HUMAN :
  • Q86UU9
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC4: view

Function for TAC4 Gene

Molecular function for TAC4 Gene

UniProtKB/Swiss-Prot Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.

Gene Ontology (GO) - Molecular Function for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with TAC4: view

Phenotypes for TAC4 Gene

genes like me logo Genes that share phenotypes with TAC4: view

Animal Models for TAC4 Gene

MGI Knock Outs for TAC4:

Animal Model Products

miRNA for TAC4 Gene

miRTarBase miRNAs that target TAC4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAC4 Gene

Localization for TAC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAC4 Gene COMPARTMENTS Subcellular localization image for TAC4 gene
Compartment Confidence
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TAC4: view

Pathways for TAC4 Gene

genes like me logo Genes that share pathways with TAC4: view

Gene Ontology (GO) - Biological Process for TAC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007217 tachykinin receptor signaling pathway IEA --
GO:0008217 regulation of blood pressure IEA --
GO:0046878 positive regulation of saliva secretion IEA --
genes like me logo Genes that share ontologies with TAC4: view

Compounds for TAC4 Gene

(1) Novoseek inferred chemical compound relationships for TAC4 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with TAC4: view

Transcripts for TAC4 Gene

mRNA/cDNA for TAC4 Gene

Unigene Clusters for TAC4 Gene

Tachykinin 4 (hemokinin):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAC4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for TAC4 Gene

GeneLoc Exon Structure for
TAC4
ECgene alternative splicing isoforms for
TAC4

Expression for TAC4 Gene

mRNA expression in normal human tissues for TAC4 Gene

mRNA differential expression in normal tissues according to GTEx for TAC4 Gene

This gene is overexpressed in Pituitary (12.1).

SOURCE GeneReport for Unigene cluster for TAC4 Gene Hs.652130

mRNA Expression by UniProt/SwissProt for TAC4 Gene

Q86UU9-TKN4_HUMAN
Tissue specificity: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.
genes like me logo Genes that share expressions with TAC4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for TAC4 Gene

Orthologs for TAC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TAC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAC4 35
  • 98.58 (n)
  • 95.74 (a)
TAC4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAC4 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tac4 16
Tac4 36
  • 44 (a)
OneToOne
Species with no ortholog for TAC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAC4 Gene

ENSEMBL:
Gene Tree for TAC4 (if available)
TreeFam:
Gene Tree for TAC4 (if available)

Paralogs for TAC4 Gene

No data available for Paralogs for TAC4 Gene

Variants for TAC4 Gene

Sequence variations from dbSNP and Humsavar for TAC4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs412521 -- 49,849,369(+) tcagg(G/T)gatct upstream-variant-2KB
rs427525 -- 49,849,496(+) AGTAA(A/G)ACATT upstream-variant-2KB
rs433185 -- 49,849,484(+) TGGTA(A/G)AAAAT upstream-variant-2KB
rs437583 -- 49,849,487(+) TAAAA(A/G)ATGAG upstream-variant-2KB
rs883010 -- 49,839,435(-) TCAAC(A/C)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAC4 Gene

Variant ID Type Subtype PubMed ID
nsv821118 CNV Duplication 20802225
nsv828037 CNV Gain 20364138
nsv819145 CNV Loss 19587683
esv25474 CNV Loss 19812545

Relevant External Links for TAC4 Gene

HapMap Linkage Disequilibrium report
TAC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC4 Gene

Disorders for TAC4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAC4 Gene including...

Search for TAC4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TAC4 Gene

Relevant External Links for TAC4

Genetic Association Database (GAD)
TAC4
Human Genome Epidemiology (HuGE) Navigator
TAC4
genes like me logo Genes that share disorders with TAC4: view

No data available for UniProtKB/Swiss-Prot for TAC4 Gene

Publications for TAC4 Gene

  1. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PMID: 12383518) Kurtz M.M. … Liu Q. (Gene 2002) 2 3 4 23
  2. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PMID: 17175032) Cunningham S. … Vandenbroeck K. (J. Neuroimmunol. 2007) 3 23 48
  3. A role for tachykinins in the regulation of human sperm motility. (PMID: 17437961) Ravina C.G. … Candenas M.L. (Hum. Reprod. 2007) 4 23
  4. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PMID: 17655832) Naono R. … Nishimori T. (Brain Res. 2007) 4 23
  5. Tachykinins and tachykinin receptors in human uterus. (PMID: 12788812) Patak E. … Pinto F.M. (Br. J. Pharmacol. 2003) 4 23

Products for TAC4 Gene

Sources for TAC4 Gene

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