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Aliases & Descriptions for TAC4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EK 2 HK-1 1 , 2 MGC133009 2 MGC133010 2 PPT-C 1 , 2 , 3 Pptc 1 Preprotachykinin-C 3 endokinin 2 hemokinin 2
Descriptions preprotachykinin C 2 tachykinin 4 2 tachykinin 4 (hemokinin) 2
Search outside databases for aliases for TAC4 genePrevious GC identifers: GC17M050394 GC17M048263 GC17M048390
Summaries for TAC4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAC4 : This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykininproteins are cleaved into small, secreted peptides that activate members of a family of receptorproteins. The products of this gene preferentially activate tachykinin receptor 1, and are thoughtto regulate peripheral endocrine and paracrine functions including blood pressure, the immunesystem, and endocrine gland secretion. The products of this gene lack a dibasic cleavage sitefound in other tachykinin proteins. Consequently, the nature of the cleavage products generated invivo remains to be determined. Multiple transcript variants encoding different isoforms have beenfound for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 Function : Tachykinins are active peptides which excite neurons, evoke behavioral responses, arepotent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching followingintrathecal administration in rats. These effects are suppressed by treatment with endokinin-C.Endokinin-A/B reduces arterial blood pressure and increases sperm motility
Gene Wiki entry for TAC4
Genomic Location for TAC4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAC4 gene Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33 TAC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M045270:
(about GC identifiers )
Start:
45,270,670 bp from pter
End:
45,280,378 bp from pter
Size:
9,709 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000017.9 NT_010783.14 Proteins for TAC4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 (See
protein sequence )Recommended Name: Tachykinin-4 precursor Size : 113 amino acids; 12305 Da
Subcellular location : Secreted (Probable)
Secondary accessions : Q2M2P1 Q6ECK8 Q86UU6 Q86UU7 Q86UU8 Q8IWZ7Alternative splicing : 7 isoforms : Q86UU9-1 Q86UU9-2 Q86UU9-3 Q86UU9-4 Q86UU9-5 Q86UU9-6 Q86UU9-7
REFSEQ proteins (5 alternative transcripts):
NP_001070971.1 NP_001070972.1 NP_001070973.1 NP_001070974.1 NP_733786.2 ENSEMBL proteins: ENSP00000340461 ENSP00000325286 ENSP00000381221 ENSP00000334042 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
About this table Antibodies for TAC4: Assays for TAC4:
Protein
Domains/ Families for TAC4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q86UU9 ProtoNet protein and cluster: Q86UU9
UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 Similarity : Belongs to the tachykinin family
Gene Function for TAC4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_170685 Applied Biosystems Silencer ® siRNAs for TAC4 Sigma-Aldrich siRNA for TAC4 Sigma-Aldrich shRNA for TAC4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001077503                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001077503                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001077503  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_170685 UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 Function : Tachykinins are active peptides which excite neurons, evoke behavioral responses, arepotent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching followingintrathecal administration in rats. These effects are suppressed by treatment with endokinin-C.Endokinin-A/B reduces arterial blood pressure and increases sperm motility
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
IEA --
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Pathways & Interactions for TAC4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/11 Interacting proteins for TAC4 (ENSP00000334042 3 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007217 tachykinin receptor signaling pathway
IEA -- GO:0008217 regulation of blood pressure
IEA -- GO:0046878 positive regulation of saliva secretion
IEA --
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Drugs & Compounds for TAC4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TAC4 1 Novoseek chemical compound relationship for TAC4 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
calcium
0.00
2
15913794 (1), 12842130 (1)
About this table
Transcripts for TAC4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_170685 Sigma-Aldrich siRNA for TAC4 Sigma-Aldrich shRNA for TAC4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001077503 NM_001077504 NM_001077505 NM_001077506 NM_170685
REFSEQ mRNAs for TAC4 gene (5 alternative transcripts): NM_001077503.1 NM_001077504.1 NM_001077505.1 NM_001077506.1 NM_170685.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001077503 NM_001077504 NM_001077505 NM_001077506 NM_170685
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5 ): NM_001077503                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 5 ): NM_001077503                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001077503  
Additional cDNA sequence: AF515828.1 AF515829.1 AF515830.1 AF515831.1 AY471574.1 BC100840.2 BC100842.2 BC100843.2
6 DOTS entries : DT.101969251 DT.100746269 DT.100001553 DT.100746267 DT.120919236 DT.91989114
10 AceView cDNA sequences :AF515830 AF515831 NM_170685 AF521560 AF515828 AF515829 AY471574 BF837128 BF840399 BF840431
highest scoring ESTs for TAC4 :AF515828 AF515829 AF515830 AF515831 AF521560 AY471574 BC100840 BC100841 BC100842 BC100843
Unigene Clusters for TAC4: Tachykinin 4 (hemokinin) Hs.434138 [show with all ESTs ] , Hs.652130 [show with all ESTs ] Unigene Representative Sequences: XM_001133597 , AF515828 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for TAC4 ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 SP1 :   -           SP2 :             SP3 :   -     -       SP4 :   -     -   -    
About this scheme ECgene alternative splicing isoforms for TAC4 4 Ensembl transcripts including schematic representations : ENST00000352793
ENST00000326219
ENST00000398154
ENST00000334568
Expression for TAC4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAC4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAC4 1 / 2
1 probe-set matching TAC4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene clusters: Hs.434138 Hs.652130 UniProtKB/Swiss-Prot: TKN4_HUMAN, Q86UU9 Tissue specificity : Expressed at low levels in the uterus of both pregnant and non-pregnant women.Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver,bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressedpredominantly in adrenal gland and placenta. Isoform 6 is widely expressed with high levels inskin
Orthologs for TAC4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAC4 gene from 2 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
TAC41
--
tachykinin 4 (hemokinin)
98.53(n) 96.46(a)
746809 XM_001168519.1 XP_001168519.1
mouse (Mus musculus)
Tac45
11
tachykinin 4
--
BC119426
About this table Species with no ortholog for TAC4 ENSEMBL Gene Tree for TAC4 Paralogs for TAC4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for TAC4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAC4 (up to first 250kb)
Disorders & Mutations for TAC4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607833 Human Genome Epidemiology Navigator: TAC4 (1 document)
Medical News for TAC4 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAC4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for TAC4 gene (see all 20
): Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PubMed id 12383518) 1, 2, 3, 4 Kurtz M.M....Liu Q. (2002) Characterization of the endokinins: human tachykinins with cardiovascular activity. (PubMed id 12716968) 3, 4 Page N.M.... Lowry P.J. (2003) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. (PubMed id 11062498) 2, 3 Zhang Y....Paige C.J. (2000) Regulatory mechanisms in the differential expression of Hemokinin-1. (PubMed id 19081134) 1, 3 Tran A.H....Paige C.J. (2009) Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PubMed id 17655832) 1, 4 Naono R....Nishimori T. (2007) The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032) 1, 3 Cunningham S....Vandenbroeck K. (2007) Hemokinins and endokinins. (PubMed id 15224188) 1, 3 Page N.M. (2004) A role for tachykinins in the regulation of human sperm motility. (PubMed id 17437961) 1, 4 Ravina C.G....Candenas M.L. (2007) Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides. (PubMed id 16931167) 1, 3 Page N.M. (2006) Tachykinins and tachykinin receptors in human uterus. (PubMed id 12788812) 1, 4 Patak E....Pinto F.M. (2003)
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Genome Databases showing TAC4
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAC4
(According to HUGE )
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--
Specialized Databases showing TAC4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TAC4 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for TAC4:
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