Aliases for TAC4 Gene
Aliases for TAC4 Gene
External Ids for TAC4 Gene
- HGNC: 16641
- Entrez Gene: 255061
- Ensembl: ENSG00000176358
- OMIM: 607833
- UniProtKB: Q86UU9
Previous GeneCards Identifiers for TAC4 Gene
- GC17M050394
- GC17M048263
- GC17M048390
- GC17M045270
- GC17M047915
- GC17M043280
Summaries for TAC4 Gene
-
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAC4 Gene
TAC4 (Tachykinin 4 (Hemokinin)) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for TAC4 Gene
-
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC4 Gene
Genomics for TAC4 Gene
Regulatory Elements for TAC4 Gene
Enhancers for TAC4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TAC4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TAC4 gene promoter:
Regulatory Element Products
Genomic Location for TAC4 Gene
- Chromosome:
- 17
- Start:
- 49,838,309 bp from pter
- End:
- 49,848,017 bp from pter
- Size:
- 9,709 bases
- Orientation:
- Minus strand
Genomic View for TAC4 Gene
Genes around TAC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.33 by Ensembl
- 17q21.33 by Entrez Gene
- 17q21.33 by HGNC
TAC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TAC4 Gene
Proteins for TAC4 Gene
-
Protein details for TAC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86UU9-TKN4_HUMAN
- Recommended name:
- Tachykinin-4
- Protein Accession:
- Q86UU9
- Q2M2P1
- Q6ECK8
- Q86UU6
- Q86UU7
- Q86UU8
- Q8IWZ7
Protein attributes for TAC4 Gene
- Size:
- 113 amino acids
- Molecular mass:
- 12305 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00843.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI00844.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW94657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for TAC4 Gene
No Post-translational modifications
Other Protein References for TAC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TAC4
- Invitrogen Antibodies for TAC4
- antibodies-online Antibodies for TAC4: See all 18
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Protein Products
-
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No data available for DME Specific Peptides for TAC4 Gene
Domains & Families for TAC4 Gene
Gene Families for TAC4 Gene
- HGNC:
Protein Domains for TAC4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TAC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86UU9- Family:
-
- Belongs to the tachykinin family.
Function for TAC4 Gene
Molecular function for TAC4 Gene
- UniProtKB/Swiss-Prot Function:
- Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IEA | -- |
Phenotypes for TAC4 Gene
- GenomeRNAi human phenotypes for TAC4:
Animal Model Products
-
Taconic Biosciences Mouse Models for TAC4
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-
-
ViGene Biosciences ready-to-package AAV shRNAs for TAC4 gene
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CRISPR Products
-
OriGene CRISPR knockouts for TAC4
-
Applied Biological Materials CRISPR for TAC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAC4
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miRNA for TAC4 Gene
- miRTarBase miRNAs that target TAC4
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TAC4
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAC4 Gene
Localization for TAC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TAC4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
Pathways & Interactions for TAC4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
Pathways by source for TAC4 Gene
1 BioSystems pathway for TAC4 Gene
Interacting Proteins for TAC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007217 | tachykinin receptor signaling pathway | IEA | -- |
| GO:0008217 | regulation of blood pressure | IEA | -- |
| GO:0046878 | positive regulation of saliva secretion | IEA | -- |
No data available for SIGNOR curated interactions for TAC4 Gene
Transcripts for TAC4 Gene
mRNA/cDNA for TAC4 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TAC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TAC4
-
Applied Biological Materials CRISPR for TAC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TAC4
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for TAC4 gene
Clone Products
-
OriGene ORF clones in human for TAC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TAC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | |||||||||||
| SP3: | - | - | |||||||||
| SP4: | - | - | - |
Expression for TAC4 Gene
mRNA differential expression in normal tissues according to GTEx for TAC4 Gene
This gene is overexpressed in Pituitary (x12.1).
NURSA nuclear receptor signaling pathways regulating expression of TAC4 Gene:
TAC4SOURCE GeneReport for Unigene cluster for TAC4 Gene:
Hs.652130mRNA Expression by UniProt/SwissProt for TAC4 Gene:
Q86UU9-TKN4_HUMAN
Tissue specificity:
Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta.
Primer Products
-
OriGene qPCR primer pairs for TAC4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAC4 Gene
Orthologs for TAC4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TAC4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TAC4 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tac4 35 |
|
OneToOne |
- Species where no ortholog for TAC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TAC4 Gene
No data available for Paralogs for TAC4 Gene
Variants for TAC4 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000363890 | -- | 49,841,025(+) | CAGGC(A/C)CCTGC | intron-variant | |
| rs1000580865 | -- | 49,840,563(+) | AGTGG(C/T)GTGAT | intron-variant | |
| rs1000778850 | -- | 49,846,990(+) | CCTGC(C/T)GCCCT | intron-variant, reference, synonymous-codon | |
| rs1001020421 | -- | 49,842,842(+) | TTTTT(C/T)AAAAA | intron-variant | |
| rs1001034785 | -- | 49,840,379(+) | GAGCT(A/G)GTTAG | intron-variant |
Residual Variation Intolerance Score:
68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.01;
50.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TAC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TAC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC4 Gene
Disorders for TAC4 Gene
Relevant External Links for TAC4
No disorders were found for TAC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAC4 Gene
Publications for TAC4 Gene
- Identification, localization and receptor characterization of novel mammalian substance P-like peptides. (PMID: 12383518) Kurtz M.M. … Liu Q. (Gene 2002) 2 3 4 22 64
- The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PMID: 17175032) Cunningham S. … Vandenbroeck K. (J. Neuroimmunol. 2007) 3 22 46 64
- Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PMID: 20580442) Klassert T.E. … HernA!ndez M. (J. Neuroimmunol. 2010) 3 46 64
- Regulatory mechanisms in the differential expression of Hemokinin-1. (PMID: 19081134) Tran A.H. … Paige C.J. (Neuropeptides 2009) 3 22 64
- Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. (PMID: 17655832) Naono R. … Nishimori T. (Brain Res. 2007) 4 22 64
Products for TAC4 Gene
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- Custom Antibody ServicesOriGene Antibodies for TAC4
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- VectorBuilder custom plasmid, inducible vectors for TAC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TAC4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TAC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (118) ClinicalTrials
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- (141) ENCODE
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio