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Aliases for TAC3 Gene

Aliases for TAC3 Gene

  • Tachykinin 3 2 3 5
  • Preprotachykinin-B 2 3
  • Neuromedin K 2 3
  • ZNEUROK1 3 4
  • NKNB 3 4
  • Gamma Tachykinin 3 3
  • Preprotachykinin B 3
  • Neurokinin Beta 2
  • Neurokinin B 3
  • PRO1155 3
  • HH10 3
  • NKB 3

External Ids for TAC3 Gene

Previous HGNC Symbols for TAC3 Gene

  • NKNB

Previous GeneCards Identifiers for TAC3 Gene

  • GC12M057378
  • GC12M057628
  • GC12M057120
  • GC12M055690
  • GC12M057403
  • GC12M054443

Summaries for TAC3 Gene

Entrez Gene Summary for TAC3 Gene

  • This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for TAC3 Gene

TAC3 (Tachykinin 3) is a Protein Coding gene. Diseases associated with TAC3 include hypogonadotropic hypogonadism 10 with or without anosmia and tac3-related isolated gonadotropin-releasing hormone deficiency. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for TAC3 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.

Tocris Summary for TAC3 Gene

  • The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC3 Gene

Genomics for TAC3 Gene

Genomic Location for TAC3 Gene

Chromosome:
12
Start:
57,009,997 bp from pter
End:
57,028,883 bp from pter
Size:
18,887 bases
Orientation:
Minus strand

Genomic View for TAC3 Gene

Genes around TAC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAC3 Gene

Proteins for TAC3 Gene

  • Protein details for TAC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF0-TKNK_HUMAN
    Recommended name:
    Tachykinin-3
    Protein Accession:
    Q9UHF0
    Secondary Accessions:
    • Q6IAG2
    • Q71BC6
    • Q71BC9

    Protein attributes for TAC3 Gene

    Size:
    121 amino acids
    Molecular mass:
    13438 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TAC3 Gene

    Alternative splice isoforms for TAC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC3 Gene

Proteomics data for TAC3 Gene at MOPED

Post-translational modifications for TAC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TAC3 Gene

Domains & Families for TAC3 Gene

Gene Families for TAC3 Gene

Protein Domains for TAC3 Gene

Suggested Antigen Peptide Sequences for TAC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHF0

UniProtKB/Swiss-Prot:

TKNK_HUMAN :
  • Belongs to the tachykinin family.
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC3: view

Function for TAC3 Gene

Molecular function for TAC3 Gene

GENATLAS Biochemistry:
tachykinin 3,neurokinin B (neuromedin K)
UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.
genes like me logo Genes that share phenotypes with TAC3: view

Human Phenotype Ontology for TAC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAC3 Gene

MGI Knock Outs for TAC3:

Animal Model Products

miRNA for TAC3 Gene

miRTarBase miRNAs that target TAC3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TAC3 Gene

Localization for TAC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAC3 Gene COMPARTMENTS Subcellular localization image for TAC3 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with TAC3: view

Pathways & Interactions for TAC3 Gene

genes like me logo Genes that share pathways with TAC3: view

Gene Ontology (GO) - Biological Process for TAC3 Gene

None

No data available for SIGNOR curated interactions for TAC3 Gene

Drugs & Compounds for TAC3 Gene

(26) Drugs for TAC3 Gene - From: Novoseek, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 154
Senktide Pharma Full agonist, Agonist Tachykinin NK3 agonist 0
Fosaprepitant dimeglumine salt Pharma Neurokinin-1 antagonist 0
SB 218795 Pharma Antagonist Potent, selective non-peptide NK3 antagonist 0
SB 222200 Pharma Antagonist Potent, selective non-peptide NK3 antagonist. Brain penetrant 0

(5) Additional Compounds for TAC3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SB 223412
Antagonist 174636-32-9
SSR 146977 hydrochloride
264618-38-4

(5) Tocris Compounds for TAC3 Gene

Compound Action Cas Number
SB 218795 Potent, selective non-peptide NK3 antagonist 174635-53-1
SB 222200 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174635-69-9
SB 223412 Potent, selective non-peptide NK3 antagonist. Brain penetrant 174636-32-9
Senktide Tachykinin NK3 agonist 106128-89-6
SSR 146977 hydrochloride Potent and selective NK3 antagonist 264618-38-4

(2) ApexBio Compounds for TAC3 Gene

Compound Action Cas Number
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
genes like me logo Genes that share compounds with TAC3: view

Transcripts for TAC3 Gene

Unigene Clusters for TAC3 Gene

Tachykinin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - -
SP10:

Relevant External Links for TAC3 Gene

GeneLoc Exon Structure for
TAC3
ECgene alternative splicing isoforms for
TAC3

Expression for TAC3 Gene

mRNA expression in normal human tissues for TAC3 Gene

mRNA differential expression in normal tissues according to GTEx for TAC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.4), Brain - Caudate (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.8), Stomach (x4.4), Brain - Frontal Cortex (BA9) (x4.3), and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for TAC3 Gene

This gene is overexpressed in Placenta (45.5), Vitreous humor (15.6), and Platelet (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAC3 Gene



SOURCE GeneReport for Unigene cluster for TAC3 Gene Hs.9730

genes like me logo Genes that share expression patterns with TAC3: view

Protein tissue co-expression partners for TAC3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAC3 Gene

Orthologs for TAC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAC3 35
  • 79.61 (n)
  • 68.6 (a)
TAC3 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAC3 35
  • 81.67 (n)
  • 75 (a)
TAC3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tac2 35
  • 76.58 (n)
  • 69.37 (a)
Tac2 16
Tac2 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAC3 35
  • 99.72 (n)
  • 99.17 (a)
TAC3 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tac3 35
  • 75.38 (n)
  • 66.67 (a)
oppossum
(Monodelphis domestica)
Mammalia TAC3 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAC3 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAC3 36
  • 37 (a)
OneToOne
Species with no ortholog for TAC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAC3 Gene

ENSEMBL:
Gene Tree for TAC3 (if available)
TreeFam:
Gene Tree for TAC3 (if available)

Paralogs for TAC3 Gene

No data available for Paralogs for TAC3 Gene

Variants for TAC3 Gene

Sequence variations from dbSNP and Humsavar for TAC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121918123 Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) 57,012,845(-) ACTTA(C/T)GGGCA intron-variant, nc-transcript-variant, reference, missense
VAR_069969 Hypogonadotropic hypogonadism 10 with or without anosmia (HH10)
rs695934 -- 57,017,061(-) tctcg(A/G)tctct upstream-variant-2KB
rs733629 -- 57,012,660(+) AGACT(C/T)TCCTG intron-variant, nc-transcript-variant
rs2122694 -- 57,014,549(-) TGAGA(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAC3 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV Gain 17160897
nsv820171 CNV Loss 19587683

Variation tolerance for TAC3 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAC3 Gene

HapMap Linkage Disequilibrium report
TAC3
Human Gene Mutation Database (HGMD)
TAC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC3 Gene

Disorders for TAC3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TAC3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 10 with or without anosmia
  • hh10
tac3-related isolated gonadotropin-releasing hormone deficiency
  • hypogonadotropic hypogonadism 10 with or without anosmia
pre-eclampsia
  • preeclampsia
eclampsia
  • eclampsia in puerperium
hypogonadism
- elite association - COSMIC cancer census association via MalaCards
Search TAC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TKNK_HUMAN
  • Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:19079066, ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TAC3

Genetic Association Database (GAD)
TAC3
Human Genome Epidemiology (HuGE) Navigator
TAC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAC3
genes like me logo Genes that share disorders with TAC3: view

No data available for Genatlas for TAC3 Gene

Publications for TAC3 Gene

  1. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (PMID: 10866201) Page N.M. … Lowry P.J. (Nature 2000) 2 3 4 23 67
  2. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. (PMID: 18614256) Rance N.E. (Peptides 2009) 3 23
  3. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PMID: 19079066) Topaloglu A.K. … Semple R.K. (Nat. Genet. 2009) 3 23
  4. The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family. (PMID: 19539370) Gillies S. … Quinn J.P. (Neuropeptides 2009) 3 23
  5. Altered circulating neurokinin B (NKB) levels are not due to sequence variants in the encoding genes. (PMID: 17976896) Tofa K.C. … Hillermann R. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008) 3 23

Products for TAC3 Gene

Sources for TAC3 Gene

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