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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TAC3 Gene

protein-coding GIFtS: 60
GCID: GC12M057403

tachykinin 3

(Previous names: neuromedin K, neurokinin beta )
(Previous symbol: NKNB)

Explore 18 diseases affiliated with
TAC3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tachykinin 3¹ ²		HH10²
NKNB¹ ² ³ ⁵		PRO1155²
ZNEUROK1¹ ² ³		Gamma Tachykinin 3²
NKB¹ ²		Preprotachykinin B²
Neuromedin K¹ ²		Tachykinin-3¹
Neurokinin Beta¹

External Ids:	HGNC: 11521¹	Entrez Gene: 6866²	Ensembl: ENSG00000166863⁷	OMIM: 162330⁵	UniProtKB: Q9UHF0³

Export aliases for TAC3 gene to outside databases

Previous GC identifers: GC12M057378 GC12M057628 GC12M057120 GC12M055690 GC12M054443

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAC3:

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily

expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand

for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may

be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with

normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. (provided by

RefSeq, May 2010)

UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity)

summary for TAC3:

The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins

have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins

have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1

has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main

tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TAC3 gene promoter:
HSF1 (long) HNF-4alpha1 C/EBPalpha Meis-1b CHOP-10 SEF-1 (1) HSF1short Meis-1a TGIF Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAC3 promoter sequence

Search SABiosciences Chromatin IP Primers for TAC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13-q21 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13-q21

TAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M057403: view genomic region (about GC identifiers)

Start:	57,403,781 bp from pter	End:	57,422,667 bp from pter
Size:	18,887 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0 (See protein sequence)

Recommended Name: Tachykinin-3 precursor

Size: 121 amino acids; 13438 Da

Subcellular location: Secreted

Developmental stage: In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta,

significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are

grossly elevated in pregnancy-induced hypertension and pre-eclampsia

1 PDB 3D structure from and Proteopedia for TAC3:

1P9F (3D)

Secondary accessions: Q6IAG2 Q71BC6 Q71BC9

Alternative splicing: 3 isoforms: Q9UHF0-1 Q9UHF0-2 Q9UHF0-3

Explore the universe of human proteins at neXtProt for TAC3: NX_Q9UHF0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UHF0

TAC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171525.1 NP_037383.1

ENSEMBL proteins:

ENSP00000350236 ENSP00000404056 ENSP00000408131 ENSP00000377445 ENSP00000368721

ENSP00000408208 ENSP00000416292 ENSP00000300108 ENSP00000402995

Reactome Protein details: Q9UHF0
Human Recombinant Protein Products for TAC3:

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	Uscn Proteins for TAC3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	TAS	10866201
GO:0005625	soluble fraction	--	--

TAC3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TAC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAC3 for domains About GeneDecksing

2 InterPro domains/families:

IPR003635 Neurokinin

IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry Q9UHF0

ProtoNet protein and cluster: Q9UHF0

1 Blocks protein family: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0

Similarity: Belongs to the tachykinin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TKNK_HUMAN, Q9UHF0

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity)

Genatlas biochemistry entry for TAC3:

tachykinin 3,neurokinin B (neuromedin K)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	10866201

TAC3 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tac2):

behavior/neurological

mortality/aging

normal

TAC3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tac2^tm1Lex for TAC3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TAC3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Tachykinin receptors bind tachykinins

Tachykinin receptors bind tachykinins

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 Reactome Pathways for TAC3 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

TAC3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TAC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/132 Interacting proteins for TAC3 (Q9UHF0^{2, 3} ENSP00000300108⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC90B	Q9GZT6²^,³	MINT-65740 I2D: score=4
FEZ1	Q99689²^,³	MINT-65739 I2D: score=4
GPRASP1	Q5JY77²^,³	MINT-65737 I2D: score=4
PTN	P21246²^,³	MINT-65735 I2D: score=4
UBR1	Q8IWV7²^,³	MINT-65738 I2D: score=4

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007217	tachykinin receptor signaling pathway	IEA	--
GO:0007218	neuropeptide signaling pathway	IEA	--
GO:0007565	female pregnancy	TAS	10866201
GO:0043278	response to morphine	--	--
GO:0045777	positive regulation of blood pressure	--	--

TAC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TAC3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TAC3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Neurokinin B (human, porcine)	Endogenous tachykinin peptide	[86933-75-7]
SB 222200	Potent, selective non-peptide NK3 antagonist. Brain penetrant	[174635-69-9]
SB 218795	Potent, selective non-peptide NK3 antagonist	[174635-53-1]
Senktide	Tachykinin NK3 agonist	[106128-89-6]

10/25 Novoseek chemical compound relationships for TAC3 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
senktide	93.4	21	10953048 (2), 8818331 (2), 19755480 (2), 7830490 (1) (see all 14)
eledoisin	86.6	9	1708071 (3), 1712834 (1), 16127708 (1), 1694464 (1) (see all 5)
septide	85.5	5	7824047 (1), 8882625 (1), 10753681 (1)
physalaemin	76.3	6	1708071 (3), 7824047 (1), 1694464 (1)
kassinin	74.4	3	8859022 (1), 7684358 (1)
thiorphan	69.2	2	12788812 (1), 11071311 (1)
atropine	55.1	1	7516254 (1)
bestatin	53.4	2	12788812 (1), 11071311 (1)
mepyramine	46.2	1	8882625 (1)
tetrodotoxin	45	3	9203129 (1), 7869272 (1)

Search CenterWatch for drugs/clinical trials and news about TAC3 / TKNK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAC3 gene (3 alternative transcripts):

NM_001178054.1 NM_013251.3 NM_001006667.1

Unigene Cluster for TAC3:

Tachykinin 3

Hs.9730 [show with all ESTs]

Unigene Representative Sequence: AY358679

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357616(uc010sqy.2) ENST00000458521(uc001smp.3 uc001smo.3)

ENST00000438756(uc001sms.3 uc001smt.3) ENST00000393867(uc001smq.3)

ENST00000379411(uc001smu.3) ENST00000441881 ENST00000423597(uc001smv.3)

ENST00000300108(uc001smr.3) ENST00000415231 ENST00000496757

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Additional cDNA sequence:

AF186112.1 AF216586.1 AF537115.1 AF537118.1 AF537121.1 AY358679.1 BC032145.2 CR457193.1

NR_033654.1

4 DOTS entries:

DT.410221 DT.101983456 DT.101983455 DT.101974196

24/81 AceView cDNA sequences (see all 81):

BX118017 AF537118 NM_005379 BC032145 AF537116 AF537114 AF537115 AF105424

AU098730 BG002828 AF537119 AF127026 BX479591 AI139283 AF537117 AI832211

BC059387 AF537113 AY358679 CD620409 AF186112 AF537121 NM_013251 CD620413

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TAC3 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:													-
SP2:													-										-
SP3:													-				-
SP4:													-								-		-
SP5:													-				-						-

ECgene alternative splicing isoforms for TAC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTCTTTGT

About this image

TAC3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See TAC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAC3

SOURCE GeneReport for Unigene cluster: Hs.9730

SABiosciences Custom PCR Arrays for TAC3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TAC3 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tac2^{1 , 5}	tachykinin 2^{1, 5}	76.88(n)¹ 69.37(a)¹		10 (74.81 cM)⁵ 21334¹ NM_001199971.1¹ NP_001186900.1¹ 127724478⁵
lizard (Anolis carolinensis)	Reptilia	TAC3⁶	--	35(a)	1 ↔ 1	2(95258980-95265826)

ENSEMBL Gene Tree for TAC3 (if available)
TreeFam Gene Tree for TAC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113641374^1,2		--	54441978(+)	`ACCTCA/GTGATC`	3	--	ds500¹		2	CSA	3
rs59141506^1,2	C	--	54442553(+)	`CGTGCG/ACACCT`	3	--	nc-transcript-variantut3¹		2	CSA WA	120
rs11609825^1,2	C,A,H	--	54442744(+)	`GAGAGG/CAAAGA`	3	--	int¹ trp³		6	NA	254
rs113135113^1,2		--	54443189(+)	`CCTCAG/ATGGTA`	3	--	int¹		1	CSA	2
rs117513059^1,2	C,F	--	54443404(+)	`GCCGTC/TGGCAG`	3	--	int¹		1	NA	120
rs74808980^1,2	C,F	--	54444049(+)	`CTTTCA/GTTTTT`	3	--	int¹		3	NA	124
rs59613457^1,2	C,F	--	54444357(+)	`TTATCA/GGATAA`	3	--	int¹		4	WA CSA	123
rs75382504^1,2	F	--	54444369(+)	`AATTTC/TTCCAT`	3	--	int¹		1	WA	118
rs76333711^1,2	F	--	54444681(+)	`CCCCTC/TTCCCC`	3	--	int¹		1	NA	6
rs2270734^1,2	C,F,H	--	54444870(-)	`ACTGCC/TCGTCA`	3	--	int¹		11	EA NS NA	2506

HapMap Linkage Disequilibrium report for TAC3 (57403781 - 57422667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAC3
1 Indel: 58582
Human Gene Mutation Database (HGMD): TAC3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAC3 for disorders           About GeneDecksing

OMIM gene information: 162330
OMIM disorders: 146110
18 diseases for TAC3:    About MalaCards

pre-eclampsia hypogonadotropism eclampsia hypogonadism

hypertension neurogenic bladder interstitial lung disease kallmann syndrome

klinefelter's syndrome neuronitis constipation rheumatoid arthritis

multiple sclerosis arthritis asthma cerebritis

esophagitis isolated gonadotropin-releasing hormone (gnrh) deficiency

3 diseases from the University of Copenhagen DISEASES database for TAC3:

Klinefelter's syndrome pre-eclampsia Hypogonadism

4 Novoseek disease relationships for TAC3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia	55.2	29	16709596 (4), 17318561 (2), 17480147 (2), 10866201 (2) (see all 12)
hypertrophy	27	4	14764001 (1), 10095095 (1), 19094085 (1), 18614256 (1)
inflammation	3.19	2	11049735 (1), 7684358 (1)
edema	0	1	11049735 (1)

Human Genome Epidemiology (HuGE) Navigator: TAC3 (6 documents)

Export disorders for TAC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TAC3 gene, integrated from 9 sources (see all 153):
(articles sorted by number of sources associating them with TAC3)

Utopia: connect your pdf to the dynamic
world of online information

Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (PubMed id 10866201)^{1, 2, 3, 9} Page N.M.... Lowry P.J. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
A cDNA encoding the precursor of the rat neuropeptide, neurokinin B. (PubMed id 3479225)^{1, 3} Bonner T.I....Young W.S. (1987)
[Relationship between neurokinin B and endothelin-1 and hypertensive disorders complicating pregnancy] (PubMed id 19087492)^{1, 9} Li Z.M....Wang Z.H. (2008)
Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels. (PubMed id 14700748)^{1, 9} Laliberte C....Kaufman S. (2004)
The human neurokinin B gene, TAC3, and its promoter a re regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family. (PubMed id 19539370)^{1, 9} Gillies S....Quinn J.P. (2009)
Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia. (PubMed id 16709596)^{1, 9} Page N.M....Morrish D.W. (2006)
Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women. (PubMed id 1708331)^{1, 9} Rance N.E. and Young W.S. (1991)
Third trimester plasma neurokinin B levels in women with and without preeclampsia. (PubMed id 18240076)^{1, 9} Geissbuehler V....Moser R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6866	HGNC: 11521	AceView: MYO1AandTAC3	Ensembl:ENSG00000166863	euGenes: HUgn6866
ECgene: TAC3	H-InvDB: TAC3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TAC3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TAC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TAC3 gene:
Search GeneIP for patents involving TAC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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