Aliases for TAC3 Gene
External Ids for TAC3 Gene
Previous HGNC Symbols for TAC3 Gene
Previous GeneCards Identifiers for TAC3 Gene
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
GeneCards Summary for TAC3 Gene
TAC3 (Tachykinin 3) is a Protein Coding gene. Diseases associated with TAC3 include Hypogonadotropic Hypogonadism 10 With Or Without Anosmia and Tac3-Related Isolated Gonadotropin-Releasing Hormone Deficiency. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for TAC3 Gene
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function.
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.