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TAC3 Gene

protein-coding   GIFtS: 59
GCID: GC12M057403

Tachykinin 3

(Previous names: neuromedin K, neurokinin beta)
(Previous symbol: NKNB)
  See TAC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tachykinin 31 2     NKB2
NKNB1 2 3 5     PRO11552
Neuromedin K1 2     Gamma Tachykinin 32
preprotachykinin-B1 2     Neurokinin B2
ZNEUROK12 3     Preprotachykinin B2
HH102 5     tachykinin-32
Neurokinin Beta1     

External Ids:    HGNC: 115211   Entrez Gene: 68662   Ensembl: ENSG000001668637   OMIM: 1623305   UniProtKB: Q9UHF03   

Export aliases for TAC3 gene to outside databases

Previous GC identifers: GC12M057378 GC12M057628 GC12M057120 GC12M055690 GC12M054443


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAC3 Gene:
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily
expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the
ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the
placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are
associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, May 2010)

GeneCards Summary for TAC3 Gene:
TAC3 (tachykinin 3) is a protein-coding gene. Diseases associated with TAC3 include hypogonadotropic hypogonadism 10 with or without anosmia, and eclampsia. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a
critical central regulator of gonadal function

summary for TAC3 Gene:
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins
have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins
have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1
has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main
tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAC3 gene promoter:
         HSF1 (long)   HNF-4alpha1   C/EBPalpha   Meis-1b   CHOP-10   SEF-1 (1)   HSF1short   Meis-1a   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAC3 promoter sequence
   Search Chromatin IP Primers for TAC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13-q21   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13-q21

TAC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057403:  view genomic region     (about GC identifiers)

Start:
57,403,781 bp from pter      End:
57,422,667 bp from pter
Size:
18,887 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0 (See protein sequence)
Recommended Name: Tachykinin-3 precursor  
Size: 121 amino acids; 13438 Da
Developmental stage: In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the
placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma
concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia
1 PDB 3D structure from and Proteopedia for TAC3:
1P9F (3D)    
Secondary accessions: Q6IAG2 Q71BC6 Q71BC9
Alternative splicing: 3 isoforms:  Q9UHF0-1   Q9UHF0-2   Q9UHF0-3   

Explore the universe of human proteins at neXtProt for TAC3: NX_Q9UHF0

Explore proteomics data for TAC3 at MOPED


See TAC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001171525.1  NP_037383.1  

ENSEMBL proteins: 
 ENSP00000350236   ENSP00000404056   ENSP00000408131   ENSP00000377445   ENSP00000368721  
 ENSP00000408208   ENSP00000416292   ENSP00000300108   ENSP00000402995  
Reactome Protein details: Q9UHF0

TAC3 Human Recombinant Protein Products:

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Novus Biologicals TAC3 Lysate
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ProSpec Recombinant Protein for TAC3
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Search eBioscience for ELISAs for TAC3 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR003635 Neurokinin-B/TAC3
 IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry Q9UHF0

ProtoNet protein and cluster: Q9UHF0

1 Blocks protein domain: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0
Similarity: Belongs to the tachykinin family


Find genes that share domains with TAC3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TKNK_HUMAN, Q9UHF0
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a
critical central regulator of gonadal function

     Genatlas biochemistry entry for TAC3:
tachykinin 3,neurokinin B (neuromedin K)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS10866201
GO:0005515protein binding IPI--
     
Find genes that share ontologies with TAC3           About GenesLikeMe


Phenotypes:
     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tac2):
 behavior/neurological  mortality/aging  normal 

Find genes that share phenotypes with TAC3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Tac2tm1Lex for TAC3

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAC3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAC3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAC3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAC3

miRNA
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miRTarBase miRNAs that target TAC3:
hsa-mir-26b-5p (MIRT029228)

Block miRNA regulation of human, mouse, rat TAC3 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate TAC3:
hsa-miR-653 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidTAC3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TAC3

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GenScript: all cDNA clones in your preferred vector (see all 2): TAC3 (NM_013251)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC3
Addgene plasmids for TAC3 

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TKNK_HUMAN, Q9UHF0: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space TAS10866201

Find genes that share ontologies with TAC3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TAC3 About    
See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
Tachykinin receptors bind tachykinins0.00
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90


Find genes that share SuperPaths with TAC3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Reactome Pathways for TAC3
    Tachykinin receptors bind tachykinins
G alpha (q) signalling events


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAC3
Interactions:

    Search GeneGlobe Interaction Network for TAC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TAC3 (Q9UHF01, 2, 3 ENSP000003001084) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
InteractantInteraction Details
GeneCardExternal ID(s)
CCDC90BQ9GZT62, 3MINT-65740 I2D: score=4 
FEZ1Q996892, 3MINT-65739 I2D: score=4 
GPRASP1Q5JY772, 3MINT-65737 I2D: score=4 
PTNP212462, 3MINT-65735 I2D: score=4 
UBR1Q8IWV72, 3MINT-65738 I2D: score=4 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007217tachykinin receptor signaling pathway IEA--
GO:0007218neuropeptide signaling pathway IEA--
GO:0007565female pregnancy TAS10866201

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for TAC3 available from Tocris Bioscience    About this table
CompoundAction CAS #
SSR 146977 hydrochloridePotent and selective NK3 antagonist[264618-44-2]
SB 222200 Potent, selective non-peptide NK3 antagonist. Brain penetrant [174635-69-9]
SB 218795 Potent, selective non-peptide NK3 antagonist [174635-53-1]
SenktideTachykinin NK3 agonist[106128-89-6]

Selected Novoseek inferred chemical compound relationships for TAC3 gene (see all 25)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
senktide 93.4 21 10953048 (2), 8818331 (2), 19755480 (2), 7830490 (1) (see all 14)
eledoisin 86.6 9 1708071 (3), 1712834 (1), 16127708 (1), 1694464 (1) (see all 5)
septide 85.5 5 7824047 (1), 8882625 (1), 10753681 (1)
physalaemin 76.3 6 1708071 (3), 7824047 (1), 1694464 (1)
kassinin 74.4 3 8859022 (1), 7684358 (1)
thiorphan 69.2 2 12788812 (1), 11071311 (1)
atropine 55.1 1 7516254 (1)
bestatin 53.4 2 12788812 (1), 11071311 (1)
mepyramine 46.2 1 8882625 (1)
tetrodotoxin 45 3 9203129 (1), 7869272 (1)



Find genes that share compounds with TAC3           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TAC3 gene (3 alternative transcripts): 
NM_001178054.1  NM_013251.3  NM_001006667.1  

Unigene Cluster for TAC3:

Tachykinin 3
Hs.9730  [show with all ESTs]
Unigene Representative Sequence: AY358679
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000357616(uc010sqy.2) ENST00000458521(uc001smp.3 uc001smo.3)
ENST00000438756(uc001sms.3 uc001smt.3) ENST00000393867(uc001smq.3)
ENST00000379411(uc001smu.3) ENST00000441881 ENST00000423597(uc001smv.3)
ENST00000300108(uc001smr.3) ENST00000415231 ENST00000496757
miRNA
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2 qRT-PCR Assays for microRNAs that regulate TAC3:
hsa-miR-653 hsa-miR-330-3p
SwitchGear 3'UTR luciferase reporter plasmidTAC3 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector (see all 2): TAC3 (NM_013251)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC3
Addgene plasmids for TAC3 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TAC3
OriGene qSTAR qPCR primer pairs in human, mouse for TAC3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAC3
  QuantiTect SYBR Green Assays in human, mouse, rat TAC3
  QuantiFast Probe-based Assays in human, mouse, rat TAC3

Additional mRNA sequence: 

AF186112.1 AF216586.1 AF537115.1 AF537118.1 AF537121.1 AY358679.1 BC032145.2 CR457193.1 
NR_033654.1 

4 DOTS entries:

DT.410221  DT.101983456  DT.101983455  DT.101974196 

Selected AceView cDNA sequences (see all 81):

AF537120 AI832211 AF537116 CD620413 AF537115 BX118017 CD620409 BX114126 
AU098730 BG002828 AF537117 NM_005379 BX479591 AF127026 AF105424 AF537118 
AF186112 BC032145 NM_013251 AF537121 AI139283 AF537114 AF537119 AY358679 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAC3 (see all 10)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:                                      -                                             
SP2:                                      -                             -               
SP3:                                      -           -                                 
SP4:                                      -                       -     -               
SP5:                                      -           -                 -               


ECgene alternative splicing isoforms for TAC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TAC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTTCTTTGT
TAC3 Expression
About this image


TAC3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 18 entries
         Thalamus
         Olfactory Bulb   
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
 
 Placenta (Extraembryonic Tissues)
TAC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TAC3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.9730
    Custom PCR Arrays for TAC3
Primer
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OriGene qPCR primer pairs and template standards for TAC3
OriGene qSTAR qPCR primer pairs in human, mouse for TAC3
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QuantiTect SYBR Green Assays in human, mouse, rat TAC3
QuantiFast Probe-based Assays in human, mouse, rat TAC3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TAC3 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tac21 , 5 tachykinin 21, 5 76.58(n)1
69.37(a)1
  10 (74.81 cM)5
213341  NM_009312.21  NP_033338.21 
 1277244785 
lizard
(Anolis carolinensis)
Reptilia TAC36
tachykinin 3
37(a)
1 ↔ 1
2(95246985-95275456)


ENSEMBL Gene Tree for TAC3 (if available)
TreeFam Gene Tree for TAC3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TAC3 (see all 181)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219181231,2,,4
CHypogonadotropic hypogonadism 10 with or without anosmia (HH10)4 pathogenic157240386(-) ACTTAC/TGGGCA 4 T M mis1 int10--------
VAR_0699694
Hypogonadotropic hypogonadism 10 with or without anosmia (HH10)4--see VAR_0699692 R S mis40--------
rs714465931,2
C--54447035(+) GGGTGT/-TTTTT 3 -- int12Minor allele frequency- -:0.25NA CSA 4
rs1130256941,2
C--57237097(+) TTACAG/AGCATG 3 -- ds50011Minor allele frequency- A:0.50WA 2
rs1906879041,2
--57237103(+) GCATGC/TGCCAC 3 -- ds50010--------
rs1400408181,2
--57237165(+) GGTCAA/GGCTGG 3 -- ds50010--------
rs1136413741,2
C,F--57237189(+) ACCTCA/GTGATC 3 -- ds50012Minor allele frequency- G:0.33CSA 3
rs1829299771,2
--57237396(+) AATAGA/GTATAT 3 -- ds50010--------
rs1853210961,2
--57237474(+) TACCAC/TGTAGC 3 -- ds50010--------
rs1901291661,2
--57237513(+) CCAACC/GAAACA 3 -- ds50010--------

HapMap Linkage Disequilibrium report for TAC3 (57403781 - 57422667 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TAC3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv820171CNV Loss19587683
nsv832428CNV Gain17160897

Human Gene Mutation Database (HGMD): TAC3
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TAC3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162330   
OMIM disorders: 614839  
UniProtKB/Swiss-Prot: TKNK_HUMAN, Q9UHF0
  • Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 10 diseases for TAC3:    
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    hypogonadotropic hypogonadism 10 with or without anosmia    eclampsia    constipation    carney complex
    neurogenic bladder    hypogonadotropic hypogonadism 17 with or without anosmia    pre-eclampsia    hypogonadism
    interstitial lung disease    hypertension

    2 diseases from the University of Copenhagen DISEASES database for TAC3:
    Klinefelter's syndrome     Hypogonadism

    Find genes that share disorders with TAC3           About GenesLikeMe

    4 Novoseek inferred disease relationships for TAC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 55.2 29 16709596 (4), 17318561 (2), 17480147 (2), 10866201 (2) (see all 12)
    hypertrophy 27 4 14764001 (1), 10095095 (1), 19094085 (1), 18614256 (1)
    inflammation 3.19 2 11049735 (1), 7684358 (1)
    edema 0 1 11049735 (1)

    Genetic Association Database (GAD): TAC3
    Human Genome Epidemiology (HuGE) Navigator: TAC3 (6 documents)

    Export disorders for TAC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAC3 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with TAC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (PubMed id 10866201)1, 2, 3, 9 Page N.M.... Lowry P.J. (Nature 2000)
    2. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PubMed id 19079066)1, 2, 9 Topaloglu A.K.... Semple R.K. (Nat. Genet. 2009)
    3. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032)1, 4, 9 Cunningham S....Vandenbroeck K. (J. Neuroimmunol. 2007)
    4. Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PubMed id 20580442)1, 4 Klassert T.E....HernA!ndez M. (J. Neuroimmunol. 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation. (PubMed id 17448763)1, 4 Garcia-Barcelo M....Tam P.K. (J. Pediatr. Surg. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. A cDNA encoding the precursor of the rat neuropeptide, neurokinin B. (PubMed id 3479225)1, 3 Bonner T.I....Young W.S. (Brain Res. 1987)
    10. [Relationship between neurokinin B and endothelin-1 and hypertensive disorders complicating pregnancy]. (PubMed id 19087492)1, 9 Li Z.M....Wang Z.H. (Zhonghua Fu Chan Ke Za Zhi 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6866 HGNC: 11521 AceView: MYO1AandTAC3 Ensembl:ENSG00000166863 euGenes: HUgn6866
    ECgene: TAC3 H-InvDB: TAC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAC3 gene:
    Search GeneIP for patents involving TAC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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