Aliases for TAC1 Gene
- Tachykinin Precursor 1 2 3 5
- Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) 2 3
- Neuropeptide Gamma 2 3
- Neurokinin Alpha 2 3
- Preprotachykinin 2 3
- Neuropeptide K 2 3
- Protachykinin 2 3
- Neurokinin 1 2 3
- Neurokinin 2 2 3
- Neuromedin L 2 3
- Substance K 2 3
External Ids for TAC1 Gene
Previous HGNC Symbols for TAC1 Gene
Previous GeneCards Identifiers for TAC1 Gene
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
GeneCards Summary for TAC1 Gene
TAC1 (Tachykinin Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include Neurotrophic Keratopathy and Constipation. Among its related pathways are Peptide ligand-binding receptors and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include substance P receptor binding.
UniProtKB/Swiss-Prot for TAC1 Gene
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.