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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAC1 Gene

protein-coding   GIFtS: 63
GCID: GC07P097361

Tachykinin, Precursor 1

(Previous names: tachykinin, precursor 1 (substance K, substance P, neurokinin...)
(Previous symbols: TAC2, NKNA)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tachykinin, Precursor 11 2     preprotachykinin1 2
NKNA1 2 3 5     Substance K1 2
TAC21 2 3 5     Substance P1 2
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1,
Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K,
Neuropeptide Gamma)1 2
     PPT2 3
Neurokinin 11 2     NK22
Neurokinin 21 2     NPK2
Neurokinin Alpha1 2     Neurokinin A2
Neuromedin L1 2     protachykinin-12
Neuropeptide Gamma1 2     Tachykinin 22
Neuropeptide K1 2     NKA3

External Ids:    HGNC: 115171   Entrez Gene: 68632   Ensembl: ENSG000000061287   OMIM: 1623205   UniProtKB: P203663   

Export aliases for TAC1 gene to outside databases

Previous GC identifers: GC07P095896 GC07P096959 GC07P096973 GC07P097006 GC07P097199 GC07P091962


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAC1 Gene:
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as
the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as
neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce
behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAC1 Gene: 
TAC1 (tachykinin, precursor 1) is a protein-coding gene. Diseases associated with TAC1 include neurotrophic keratopathy, and epicondylitis, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

summary for TAC1 Gene:
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins
have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins
have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1
has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main
tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAC1 gene promoter:
         Nkx2-5   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TAC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21-q22

TAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P097361:  view genomic region     (about GC identifiers)

Start:
97,361,220 bp from pter      End:
97,369,784 bp from pter
Size:
8,565 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 96,683,759-96,692,272     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366 (See protein sequence)
Recommended Name: Protachykinin-1 precursor  
Size: 129 amino acids; 15003 Da
Subcellular location: Secreted
4 PDB 3D structures from and Proteopedia for TAC1:
2B19 (3D)        2KS9 (3D)        2KSA (3D)        2KSB (3D)    
Secondary accessions: O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1
Alternative splicing: 4 isoforms:  P20366-1   P20366-2   P20366-3   P20366-4   

Explore the universe of human proteins at neXtProt for TAC1: NX_P20366

Explore proteomics data for TAC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20366

  • TAC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAC1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_003173.1  NP_054702.1  NP_054703.1  NP_054704.1  

    ENSEMBL proteins: 
     ENSP00000321106   ENSP00000289576   ENSP00000289574  
    Reactome Protein details: P20366
    Human Recombinant Protein Products for TAC1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TAC1
    Cloud-Clone Corp. Proteins for TAC1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IEA--
    GO:0030424axon IEA--
    GO:0043025neuronal cell body IEA--

    TAC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR008215 Tachykinin
     IPR008216 Protachykinin
     IPR013055 Tachy_Neuro_lke_CS

    Graphical View of Domain Structure for InterPro Entry P20366

    ProtoNet protein and cluster: P20366

    1 Blocks protein domain: IPB002040 Tachykinin/Neurokinin

    UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366
    Similarity: Belongs to the tachykinin family


    TAC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TKN1_HUMAN, P20366
    Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
    vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

         Genatlas biochemistry entry for TAC1:
    tachykinin 1,neurokinin A (substance K) and substance P precursor gene

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031835substance P receptor binding IEA--
         
    TAC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAC1:
     Decreased nuclei size in G2M 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tac1):
     behavior/neurological  cardiovascular system  integument  renal/urinary system 

    TAC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TAC1: Tac1tm1Bbm Tac1tm1Pig

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAC1

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    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAC1:
    hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidTAC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAC1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
    5Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TAC1
        Selected targets of C/EBPbeta
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAC1
        Neuropathic Pain-Signaling in Dorsal Horn Neurons
    NK1R-mediated Non-Apoptotic PCD

    1 BioSystems Pathway for TAC1
        SIDS Susceptibility Pathways

    5/9        Reactome Pathways for TAC1 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    TAC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/144 Interacting proteins for TAC1 (P203662, 3 ENSP000003211064) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096155P463792, 3MINT-63550 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63550 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63550 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63550 I2D: score=5 
    ENSG00000233348P463792, 3MINT-63550 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002675positive regulation of acute inflammatory response IEA--
    GO:0006954inflammatory response IEA--
    GO:0007204elevation of cytosolic calcium ion concentration IDA8957234
    GO:0007217tachykinin receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway IEA--

    TAC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TAC1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MEN 10376 Potent, selective NK2 antagonist [135306-85-3]
    GR 64349 Potent, selective NK2 agonist [137593-52-3]
    GR 159897 Non-peptide, potent NK2 antagonist [158848-32-9]
    [Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist[137565-28-7]
    GR 94800 Potent, selective NK2 antagonist [141636-65-9]

    10/147 Novoseek inferred chemical compound relationships for TAC1 gene (see all 147)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    senktide 93.4 56 7544197 (5), 7824047 (3), 9543242 (2), 8864543 (2) (see all 28)
    sr48968 91.2 29 7961636 (2), 18601911 (2), 11591520 (1), 14718265 (1) (see all 21)
    nepadutant 88.6 11 16616700 (2), 11906947 (1), 15037522 (1), 11937105 (1) (see all 9)
    fk 224 88.4 10 8665034 (2), 8726939 (1), 9302648 (1), 9243258 (1) (see all 6)
    aprepitant 88 27 15973669 (2), 17722507 (1), 18719071 (1), 19148578 (1) (see all 21)
    eledoisin 87.3 44 1708071 (3), 1712834 (2), 1719434 (2), 11245256 (1) (see all 22)
    septide 86.3 42 9786514 (3), 8985159 (3), 8786533 (2), 10214937 (2) (see all 13)
    fk 888 84.3 8 7889271 (2), 9302648 (1), 7534186 (1), 8529964 (1) (see all 7)
    thiorphan 81.4 26 1317691 (4), 1690360 (2), 8214946 (2), 8256886 (2) (see all 16)
    cyclo(gln-trp-phe-gly-leu-met) 80.1 8 7544197 (1), 14985054 (1), 1964226 (1), 1713430 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TAC1 / TKN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAC1 gene (4 alternative transcripts): 
    NM_003182.2  NM_013996.2  NM_013997.2  NM_013998.2  

    Unigene Cluster for TAC1:

    Tachykinin, precursor 1
    Hs.2563  [show with all ESTs]
    Unigene Representative Sequence: NM_003182
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319273(uc003uop.4 uc003uoq.4 uc003uor.4 uc003uos.4)
    ENST00000350485 ENST00000346867 ENST00000495916 ENST00000491437
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAC1:
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    SwitchGear 3'UTR luciferase reporter plasmidTAC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF050655.1 AF050656.1 AF050657.1 AF050658.1 AK222957.1 BC018047.1 CR407602.1 CR541730.1 
    M68906.1 M68907.1 U37529.1 X54469.1 

    4 DOTS entries:

    DT.110616  DT.86746127  DT.95163775  DT.121056930 

    24/43 AceView cDNA sequences (see all 43):

    CD676459 AF050656 CR407602 AF050655 AU105584 AF050658 AA814651 AF050657 
    CR541730 M68907 M68906 U37529 AI277203 BM712701 BQ446483 NM_013998 
    BI669514 NM_013996 BI599782 BC018047 AU099398 X54469 BI669433 NM_003182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAC1 expression in normal human tissues (normalized intensities)      TAC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTGACT
    TAC1 Expression
    About this image


    TAC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Root Ganglion   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Retina
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced MEL2 cells

    See TAC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAC1

    SOURCE GeneReport for Unigene cluster: Hs.2563
        SABiosciences Expression via Pathway-Focused PCR Array including TAC1: 
              Huntington's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TAC1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tac11 , 5 tachykinin 11, 5 93.54(n)1
    95.35(a)1
      6 (3.31 cM)5
    213331  NM_009311.21  NP_033337.11 
     75550715 
    chicken
    (Gallus gallus)
    Aves TAC11 tachykinin, precursor 1 74.63(n)
    70.8(a)
      420573  XM_418674.3  XP_418674.2 
    lizard
    (Anolis carolinensis)
    Reptilia TAC16
    tachykinin, precursor 1
    69(a)
    1 ↔ 1
    6(23493962-23520571)
    zebrafish
    (Danio rerio)
    Actinopterygii CK363556.12   -- 71.74(n)    CK363556.1 


    ENSEMBL Gene Tree for TAC1 (if available)
    TreeFam Gene Tree for TAC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in TAC1 are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115444321,2
    F--97359304(+) GCAAAG/CTCCAG 4 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1875344551,2
    --97359584(+) TCCTGC/TCATGT 4 -- us2k10--------
    rs77932771,2
    C,F,H--97359585(+) cctgcC/Gatgtg 4 -- us2k118Minor allele frequency- G:0.23NS EA NA CSA WA 2341
    rs1138080281,2
    C,F--97359686(+) TCCAAC/ACTTCG 4 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1830769211,2
    --97359691(+) CCTTCA/GAAACT 4 -- us2k10--------
    rs1881567631,2
    --97359714(+) TTTCTA/GTTGTT 4 -- us2k10--------
    rs1924372561,2
    --97359817(+) TAGTAA/TACTGT 4 -- us2k10--------
    rs1442514261,2
    --97359825(+) TGTGTC/GGGCCG 4 -- us2k10--------
    rs20517941,2
    C,F,H--97359857(-) gcattC/Aaaata 4 -- us2k114Minor allele frequency- A:0.06NS EA NA CSA WA 1353
    rs1487111021,2
    C--97359966(+) ACATGC/TTGAAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAC1 (97361220 - 97369784 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv437559CNV Loss16327808
    nsv888759CNV Gain21882294
    nsv888757CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162320    OMIM disorders: --

    20/105 diseases for TAC1 (see all 105):    About MalaCards
    neurotrophic keratopathy    epicondylitis    myofascial pain syndrome    aspiration pneumonia
    vasomotor rhinitis    pain disorder    alternating hemiplegia of childhood    paine syndrome
    burning mouth syndrome    motion sickness    cryptosporidiosis    complex regional pain syndrome
    carpal tunnel syndrome    bronchitis    gastrointestinal system disease    constipation
    carcinoid syndrome    breast cyst    uterine fibroid    peripheral vascular disease

    20/30 diseases from the University of Copenhagen DISEASES database for TAC1 (see all 30):
    Pain agnosia     Asthma     Migraine     Complex regional pain syndrome
    Rhinitis     Cystitis     Fibromyalgia     Dermatitis
    Arthritis     Irritable bowel syndrome     Huntington's disease     Constipation
    Neuropathy     Cholera     Parkinson's disease     Epicondylitis
    Inflammatory bowel disease     Diarrhea     Hypertension     Pain disorder

    TAC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/59 Novoseek inferred disease relationships for TAC1 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 54.2 67 14749007 (6), 18507649 (5), 15707850 (4), 11991878 (3) (see all 32)
    inflammation 54 42 9038887 (1), 16290928 (1), 17170385 (1), 2390021 (1) (see all 34)
    astrocytoma 37.2 4 7875535 (1), 10415087 (1), 7521949 (1), 10753681 (1)
    migraine 33.6 12 8536297 (2), 16472331 (1), 9399010 (1), 17222167 (1) (see all 6)
    motility disorder 33 1 14670823 (1)
    bronchitis chronic 32.1 1 12794061 (1)
    serotonin syndrome 25.7 3 9637018 (2)
    carcinoid 20 3 9296223 (1), 14713258 (1), 16556667 (1)
    allergic rhinitis 14.4 1 10547475 (1)
    pulmonary disease chronic obstructive 12.4 3 15707854 (2), 15544859 (1)

    Genetic Association Database (GAD): TAC1
    Human Genome Epidemiology (HuGE) Navigator: TAC1 (20 documents)

    Export disorders for TAC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAC1 gene, integrated from 9 sources (see all 927):
    (articles sorted by number of sources associating them with TAC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PubMed id 1708336)1, 2, 3 Chiwakata C....Ivell R. (1991)
    2. Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PubMed id 16503654)1, 2, 9 Dike A. and Cowsik S.M. (2006)
    3. Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PubMed id 2284201)1, 2, 9 McGregor G.P. and Conlon J.M. (1990)
    4. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PubMed id 17655760)1, 4, 9 Mishra B.K....Max M.B. (2007)
    5. MicroRNAs and target site screening reveals a pre-mic roRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (2010)
    6. Common variants of the neuropeptide expressing tachyk inin genes and susceptibility to asthma: a case-control study. (PubMed id 20580442)1, 4 Klassert T.E....HernA!ndez M. (2010)
    7. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    8. Frequencies of polymorphisms in cytokines, neurotrans mitters and adrenergic receptors in patients with complex regional pain syndrom e type I after distal radial fracture. (PubMed id 20173430)1, 4 Herlyn P....Gradl G. (2010)
    9. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6863 HGNC: 11517 AceView: TAC1 Ensembl:ENSG00000006128 euGenes: HUgn6863
    ECgene: TAC1 H-InvDB: TAC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAC1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Neurokinin_1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAC1 gene:
    Search GeneIP for patents involving TAC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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