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Aliases for TAC1 Gene

Aliases for TAC1 Gene

  • Tachykinin, Precursor 1 2 3
  • Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) 2 3
  • Neuropeptide Gamma 2 3
  • Neurokinin Alpha 2 3
  • Preprotachykinin 2 3
  • Neuropeptide K 2 3
  • Neurokinin 1 2 3
  • Neurokinin 2 2 3
  • Neuromedin L 2 3
  • Neurokinin A 3 6
  • Substance K 2 3
  • Substance P 2 3
  • NKNA 3 4
  • TAC2 3 4
  • PPT 3 4
  • Protachykinin-1 3
  • Tachykinin 2 3
  • Hs.2563 3
  • NK2 3
  • NPK 3
  • NKA 4

External Ids for TAC1 Gene

Previous HGNC Symbols for TAC1 Gene

  • TAC2
  • NKNA

Previous GeneCards Identifiers for TAC1 Gene

  • GC07P095896
  • GC07P096959
  • GC07P096973
  • GC07P097006
  • GC07P097199
  • GC07P097361
  • GC07P091962

Summaries for TAC1 Gene

Entrez Gene Summary for TAC1 Gene

  • This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for TAC1 Gene

TAC1 (Tachykinin, Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include neurotrophic keratopathy and prurigo nodularis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot for TAC1 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Tocris Summary for TAC1 Gene

  • The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC1 Gene

Genomics for TAC1 Gene

Regulatory Elements for TAC1 Gene

Transcription factor binding sites by QIAGEN in the TAC1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAC1 Gene

Start:
97,731,908 bp from pter
End:
97,740,472 bp from pter
Size:
8,565 bases
Orientation:
Plus strand

Genomic View for TAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAC1 Gene

Proteins for TAC1 Gene

  • Protein details for TAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20366-TKN1_HUMAN
    Recommended name:
    Protachykinin-1
    Protein Accession:
    P20366
    Secondary Accessions:
    • O60600
    • O60601
    • Q00072
    • Q53GH4
    • Q549V0
    • Q549V1
    • Q549V2
    • Q6FHM1

    Protein attributes for TAC1 Gene

    Size:
    129 amino acids
    Molecular mass:
    15003 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TAC1 Gene

    Alternative splice isoforms for TAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC1 Gene

Proteomics data for TAC1 Gene at MOPED

Post-translational modifications for TAC1 Gene

  • The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAC1 Gene

Domains for TAC1 Gene

Gene Families for TAC1 Gene

HGNC:

Protein Domains for TAC1 Gene

Suggested Antigen Peptide Sequences for TAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20366

UniProtKB/Swiss-Prot:

TKN1_HUMAN :
  • P20366
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC1: view

Function for TAC1 Gene

Molecular function for TAC1 Gene

GENATLAS Biochemistry:
tachykinin 1,neurokinin A (substance K) and substance P precursor gene
UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Gene Ontology (GO) - Molecular Function for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23597562
GO:0031835 substance P receptor binding IEA --
genes like me logo Genes that share ontologies with TAC1: view
genes like me logo Genes that share phenotypes with TAC1: view

Animal Models for TAC1 Gene

MGI Knock Outs for TAC1:

miRNA for TAC1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAC1 Gene

Localization for TAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAC1 Gene COMPARTMENTS Subcellular localization image for TAC1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0030424 axon IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TAC1: view

Pathways for TAC1 Gene

genes like me logo Genes that share pathways with TAC1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response IEA --
GO:0006954 inflammatory response IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8957234
GO:0007217 tachykinin receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with TAC1: view

Compounds for TAC1 Gene

(5) Tocris Compounds for TAC1 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist [122063-01-8]
GR 159897 Non-peptide, potent NK2 antagonist [158848-32-9]
GR 64349 Potent, selective NK2 agonist [137593-52-3]
GR 94800 Potent, selective NK2 antagonist [141636-65-9]
MEN 10376 Potent, selective NK2 antagonist [135306-85-3]

(2) ApexBio Compounds for TAC1 Gene

Compound Action Cas Number
Fosaprepitant Neurokinin-1 antagonist [172673-20-0]
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist [265121-04-8]

(147) Novoseek inferred chemical compound relationships for TAC1 Gene

Compound -log(P) Hits PubMed IDs
senktide 93.4 38
sr48968 91.2 23
nepadutant 88.6 10
fk 224 88.4 7
aprepitant 88 22
genes like me logo Genes that share compounds with TAC1: view

Transcripts for TAC1 Gene

Unigene Clusters for TAC1 Gene

Tachykinin, precursor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAC1 Gene

No ASD Table

Relevant External Links for TAC1 Gene

GeneLoc Exon Structure for
TAC1
ECgene alternative splicing isoforms for
TAC1

Expression for TAC1 Gene

mRNA expression in normal human tissues for TAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAC1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (12.5), Brain - Putamen (basal ganglia) (11.9), and Brain - Nucleus accumbens (basal ganglia) (8.5).

Protein differential expression in normal tissues for TAC1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAC1 Gene

SOURCE GeneReport for Unigene cluster for TAC1 Gene Hs.2563

genes like me logo Genes that share expressions with TAC1: view

Expression partners for TAC1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAC1 Gene

Orthologs for TAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAC1 35
  • 93.28 (n)
  • 91.47 (a)
TAC1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAC1 35
  • 96.12 (n)
  • 99.22 (a)
TAC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tac1 35
  • 93.54 (n)
  • 95.35 (a)
Tac1 16
Tac1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAC1 35
  • 99.48 (n)
  • 98.45 (a)
TAC1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tac1 35
  • 93.02 (n)
  • 96.9 (a)
oppossum
(Monodelphis domestica)
Mammalia TAC1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAC1 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAC1 35
  • 74.63 (n)
  • 70.8 (a)
TAC1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAC1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tac1 35
  • 71.07 (n)
  • 63.21 (a)
zebrafish
(Danio rerio)
Actinopterygii tac1 35
  • 62.76 (n)
  • 47.75 (a)
tac1 36
  • 42 (a)
OneToOne
Species with no ortholog for TAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAC1 Gene

ENSEMBL:
Gene Tree for TAC1 (if available)
TreeFam:
Gene Tree for TAC1 (if available)

Paralogs for TAC1 Gene

No data available for Paralogs for TAC1 Gene

Variants for TAC1 Gene

Sequence variations from dbSNP and Humsavar for TAC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15575 -- 97,740,280(+) CTTTT(C/T)CTATT utr-variant-3-prime
rs1229434 -- 97,736,530(-) TGGTA(A/G)TATTA intron-variant
rs1397202 -- 97,739,695(+) TTCCA(A/G)TCAGA intron-variant
rs1510300 -- 97,739,437(+) AACCT(C/G)TTTAC intron-variant
rs1802867 -- 97,740,297(+) CATGG(C/T)GAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TAC1 Gene

Variant ID Type Subtype PubMed ID
nsv888757 CNV Gain 21882294
nsv888759 CNV Gain 21882294
nsv437559 CNV Loss 16327808

Relevant External Links for TAC1 Gene

HapMap Linkage Disequilibrium report
TAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAC1 Gene

Disorders for TAC1 Gene

(59) Novoseek inferred disease relationships for TAC1 Gene

Disease -log(P) Hits PubMed IDs
asthma 54.2 53
inflammation 54 34
astrocytoma 37.2 4
migraine 33.6 7
motility disorder 33 1

Relevant External Links for TAC1

Genetic Association Database (GAD)
TAC1
Human Genome Epidemiology (HuGE) Navigator
TAC1
genes like me logo Genes that share disorders with TAC1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TAC1 Gene

Publications for TAC1 Gene

  1. Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PMID: 2284201) McGregor G.P. … Conlon J.M. (Peptides 1990) 3 4 23
  2. Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PMID: 16503654) Dike A. … Cowsik S.M. (Biochemistry 2006) 3 4 23
  3. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PMID: 17655760) Mishra B.K. … Max M.B. (Mol Pain 2007) 3 23 48
  4. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PMID: 1708336) Chiwakata C. … Ivell R. (Endocrinology 1991) 2 3 4
  5. Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. (PMID: 3038549) Theodorsson-Norheim E. … Jacobsson G. (Eur. J. Biochem. 1987) 3 4

Products for TAC1 Gene

  • Addgene plasmids for TAC1

Sources for TAC1 Gene

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