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TAC1 Gene

protein-coding GIFtS: 61
GCID: GC07P097361

Tachykinin, Precursor 1

(Previous names: tachykinin, precursor 1 (substance K, substance P, neurokinin...)
(Previous symbols: TAC2, NKNA)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Tachykinin, Precursor 1¹ ²		preprotachykinin¹ ²
NKNA¹ ² ³ ⁵		Substance K¹ ²
TAC2¹ ² ³ ⁵		Substance P¹ ²
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma)¹ ²		PPT² ³
Neurokinin 1¹ ²		NK2²
Neurokinin 2¹ ²		NPK²
Neurokinin Alpha¹ ²		Neurokinin A²
Neuromedin L¹ ²		protachykinin-1²
Neuropeptide Gamma¹ ²		Tachykinin 2²
Neuropeptide K¹ ²		NKA³

External Ids:	HGNC: 11517¹	Entrez Gene: 6863²	Ensembl: ENSG00000006128⁷	OMIM: 162320⁵	UniProtKB: P20366³

Export aliases for TAC1 gene to outside databases

Previous GC identifers: GC07P095896 GC07P096959 GC07P096973 GC07P097006 GC07P097199 GC07P091962

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAC1 Gene:

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as

the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as

neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce

behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding

different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAC1 Gene:

TAC1 (tachykinin, precursor 1) is a protein-coding gene. Diseases associated with TAC1 include neurotrophic keratopathy, and prurigo nodularis. GO annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent

vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

summary for TAC1 Gene:

The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins

have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins

have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1

has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main

tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000007.14 NC_018918.2 NT_007933.16

Regulatory elements:

Regulatory transcription factor binding sites in the TAC1 gene promoter:
Nkx2-5 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TAC1 promoter sequence

Search Chromatin IP Primers for TAC1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21-q22

TAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P097361: view genomic region (about GC identifiers)

Start:	97,361,220 bp from pter	End:	97,369,784 bp from pter
Size:	8,565 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 96,683,759-96,692,272

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366 (See protein sequence)

Recommended Name: Protachykinin-1 precursor

Size: 129 amino acids; 15003 Da

4 PDB 3D structures from and Proteopedia for TAC1:

2B19 (3D)

2KS9 (3D)

2KSA (3D)

2KSB (3D)

Secondary accessions: O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1

Alternative splicing: 4 isoforms: P20366-1 P20366-2 P20366-3 P20366-4

Explore the universe of human proteins at neXtProt for TAC1: NX_P20366

Explore proteomics data for TAC1 at MOPED

See TAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_003173.1 NP_054702.1 NP_054703.1 NP_054704.1

ENSEMBL proteins:

ENSP00000321106 ENSP00000289576 ENSP00000289574

Reactome Protein details: P20366

TAC1 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ENDOLIG: Endogenous ligands

3 InterPro protein domains:

IPR008215 Tachykinin

IPR008216 Protachykinin

IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry P20366

ProtoNet protein and cluster: P20366

1 Blocks protein domain: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Similarity: Belongs to the tachykinin family

TAC1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent

vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Genatlas biochemistry entry for TAC1:

tachykinin 1,neurokinin A (substance K) and substance P precursor gene

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0031835	substance P receptor binding	IEA	--

TAC1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TAC1:

Decreased nuclei size in G2M

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tac1):

behavior/neurological

cardiovascular system

integument

normal

renal/urinary system

TAC1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for TAC1: Tac1^tm1Bbm Tac1^tm1Pig

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAC1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAC1

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		Block miRNA regulation of human, mouse, rat TAC1 using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: TAC1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TAC1
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TKN1_HUMAN, P20366: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
nucleus	3
cytoskeleton	2
mitochondrion	2
plasma membrane	2
cytosol	1
endoplasmic reticulum	1
endosome	1
golgi apparatus	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0030424	axon	IEA	--
GO:0043025	neuronal cell body	IEA	--

TAC1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TAC1 About (see all 8)

See pathways by source

SuperPath

Contained pathways About

Peptide ligand-binding receptors

	Class A/1 (Rhodopsin-like receptors)	0.71			Peptide ligand-binding receptors	0.60
	GPCR ligand binding	0.71			Tachykinin receptors bind tachykinins	0.00

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Gastrin-CREB signalling pathway via PKC and MAPK

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

G alpha (q) signalling events

0.90

Neuropathic Pain-Signaling in Dorsal Horn Neurons

Neuropathic Pain-Signaling in Dorsal Horn Neurons

0.47

Neuropeptides signaling through G protein alpha i and G protein alpha q

Neuropeptides signaling through G protein alpha i and G protein alpha q

0.46

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAC1

	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	NK1R-mediated Non-Apoptotic PCD

1 BioSystems Pathway for TAC1

SIDS Susceptibility Pathways

2 Reactome Pathways for TAC1

	Tachykinin receptors bind tachykinins
	G alpha (q) signalling events

TAC1 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including TAC1:

Huntington's Disease in human mouse rat

Interactions:

GeneGlobe Interaction Network for TAC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TAC1 (P20366^{1, 2, 3} ENSP00000321106⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 144)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000096155	P46379²^,³	MINT-63550 I2D: score=5
ENSG00000227761	P46379²^,³	MINT-63550 I2D: score=5
ENSG00000228760	P46379²^,³	MINT-63550 I2D: score=5
ENSG00000229524	P46379²^,³	MINT-63550 I2D: score=5
ENSG00000233348	P46379²^,³	MINT-63550 I2D: score=5

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Gene Ontology (GO): Selected biological process terms (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002675	positive regulation of acute inflammatory response	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007204	positive regulation of cytosolic calcium ion concentration	IDA	8957234
GO:0007217	tachykinin receptor signaling pathway	IEA	--
GO:0007218	neuropeptide signaling pathway	IEA	--

TAC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for TAC1 available from Tocris Bioscience About this table

Compound	Action	CAS #
MEN 10376	Potent, selective NK2 antagonist	[135306-85-3]
GR 64349	Potent, selective NK2 agonist	[137593-52-3]
GR 159897	Non-peptide, potent NK2 antagonist	[158848-32-9]
[Lys5,MeLeu9,Nle10]-NKA(4-10)	Selective NK2 agonist	[137565-28-7]
GR 94800	Potent, selective NK2 antagonist	[141636-65-9]

Selected Novoseek inferred chemical compound relationships for TAC1 gene (see all 147) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
senktide	93.4	56	7544197 (5), 7824047 (3), 9543242 (2), 8864543 (2) (see all 28)
sr48968	91.2	29	7961636 (2), 18601911 (2), 11591520 (1), 14718265 (1) (see all 21)
nepadutant	88.6	11	16616700 (2), 11906947 (1), 15037522 (1), 11937105 (1) (see all 9)
fk 224	88.4	10	8665034 (2), 8726939 (1), 9302648 (1), 9243258 (1) (see all 6)
aprepitant	88	27	15973669 (2), 17722507 (1), 18719071 (1), 19148578 (1) (see all 21)
eledoisin	87.3	44	1708071 (3), 1712834 (2), 1719434 (2), 11245256 (1) (see all 22)
septide	86.3	42	9786514 (3), 8985159 (3), 8786533 (2), 10214937 (2) (see all 13)
fk 888	84.3	8	7889271 (2), 9302648 (1), 7534186 (1), 8529964 (1) (see all 7)
thiorphan	81.4	26	1317691 (4), 1690360 (2), 8214946 (2), 8256886 (2) (see all 16)
cyclo(gln-trp-phe-gly-leu-met)	80.1	8	7544197 (1), 14985054 (1), 1964226 (1), 1713430 (1) (see all 5)

TAC1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TAC1 gene (4 alternative transcripts):

NM_003182.2 NM_013996.2 NM_013997.2 NM_013998.2

Unigene Cluster for TAC1:

Tachykinin, precursor 1

Hs.2563 [show with all ESTs]

Unigene Representative Sequence: NM_003182

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000319273(uc003uop.4 uc003uoq.4 uc003uor.4 uc003uos.4)

ENST00000350485 ENST00000346867 ENST00000495916 ENST00000491437

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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		7 qRT-PCR Assays for microRNAs that regulate TAC1:
		hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: TAC1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector (see all 4): TAC1 (NM_003182)
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		QuantiFast Probe-based Assays in human, mouse, rat TAC1

Additional mRNA sequence:

AF050655.1 AF050656.1 AF050657.1 AF050658.1 AK222957.1 BC018047.1 CR407602.1 CR541730.1

M68906.1 M68907.1 U37529.1 X54469.1

4 DOTS entries:

DT.110616 DT.86746127 DT.95163775 DT.121056930

Selected AceView cDNA sequences (see all 43):

CR407602 AF050655 AU105584 M68907 AF050658 CR541730 AF050656 AF050657

CD676459 AA814651 NM_013998 NM_003182 BG708227 AU099398 AI277203 NM_013997

BC018047 BM921140 BG714365 BI599782 BQ446483 AW340043 CD676460 U37529

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TAC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTTGTGACT

About this image

TAC1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 12) fully expand


Bone (Muscoskeletal System) fully expand to see all 3 entries
Zeugopod Epiphyseal End
HyStem+TGFbeta3+GDF5-induced MEL2 cells

Eye (Sensory Organs) fully expand to see all 2 entries
GABAergic Amacrine Cells Inner Nuclear Layer

Neurons
GABAergic Amacrine Cells Inner Nuclear Layer

Neural Ectoderm (Nervous System)
Neural ectoderm cells

Cartilage (Muscoskeletal System)
HyStem+TGFbeta3+GDF5-induced MEL2 cells

TAC1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TAC1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2563

Pathway & Disease-focused RT² Profiler PCR Array including TAC1:

Huntington's Disease in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TAC1 OriGene qSTAR qPCR primer pairs in human, mouse for TAC1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TAC1
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		QuantiFast Probe-based Assays in human, mouse, rat TAC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TAC1 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tac1^{1 , 5}	tachykinin 1^{1, 5}	93.54(n)¹ 95.35(a)¹		6 (3.31 cM)⁵ 21333¹ NM_009311.2¹ NP_033337.1¹ 7554879⁵
chicken (Gallus gallus)	Aves	TAC1¹	tachykinin, precursor 1	74.63(n) 70.8(a)		420573 XM_418674.4 XP_418674.2
lizard (Anolis carolinensis)	Reptilia	TAC1⁶	tachykinin, precursor 1	69(a)	1 ↔ 1	6(23493962-23520571)
tropical clawed frog (Xenopus tropicalis)	Amphibia	tac1¹	tachykinin, precursor 1	71.07(n) 63.21(a)		779508 NM_001172286.1 NP_001165757.1
zebrafish (Danio rerio)	Actinopterygii	CK363556.1²	--	71.74(n)		CK363556.1

ENSEMBL Gene Tree for TAC1 (if available)
TreeFam Gene Tree for TAC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111544432^1,2	F	--	97359304(+)	`GCAAAG/CTCCAG`	4	--	us2k¹		1		CSA	2
rs187534455^1,2		--	97359584(+)	`TCCTGC/TCATGT`	4	--	us2k¹		0	--	--	--	--
rs7793277^1,2	C,F,H	--	97359585(+)	`cctgcC/Gatgtg`	4	--	us2k¹		18		NS EA NA CSA WA	2341
rs113808028^1,2	C,F	--	97359686(+)	`TCCAAC/ACTTCG`	4	--	us2k¹		1		NA	2
rs183076921^1,2		--	97359691(+)	`CCTTCA/GAAACT`	4	--	us2k¹		0	--	--	--	--
rs188156763^1,2		--	97359714(+)	`TTTCTA/GTTGTT`	4	--	us2k¹		0	--	--	--	--
rs192437256^1,2		--	97359817(+)	`TAGTAA/TACTGT`	4	--	us2k¹		0	--	--	--	--
rs144251426^1,2		--	97359825(+)	`TGTGTC/GGGCCG`	4	--	us2k¹		0	--	--	--	--
rs2051794^1,2	C,F,H	--	97359857(-)	`gcattC/Aaaata`	4	--	us2k¹		14		NS EA NA CSA WA	1353
rs148711102^1,2	C	--	97359966(+)	`ACATGC/TTGAAA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TAC1 (97361220 - 97369784 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for TAC1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv437559	CNV	Loss	16327808
nsv888759	CNV	Gain	21882294
nsv888757	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162320 OMIM disorders: --

Selected diseases for TAC1 (see all 112):
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neurotrophic keratopathy prurigo nodularis myofascial pain syndrome epicondylitis

aspiration pneumonia vasomotor rhinitis alternating hemiplegia of childhood pain disorder

motion sickness burning mouth syndrome burns bronchitis

carpal tunnel syndrome complex regional pain syndrome paine syndrome hemiplegia

gastrointestinal system disease cryptosporidiosis constipation cystitis

Selected diseases from the University of Copenhagen DISEASES database for TAC1 (see all 30):

Pain agnosia Asthma Migraine Complex regional pain syndrome

Rhinitis Cystitis Fibromyalgia Dermatitis

Arthritis Irritable bowel syndrome Huntington's disease Constipation

Neuropathy Cholera Parkinson's disease Epicondylitis

Inflammatory bowel disease Diarrhea Hypertension Pain disorder

TAC1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for TAC1 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	54.2	67	14749007 (6), 18507649 (5), 15707850 (4), 11991878 (3) (see all 32)
inflammation	54	42	9038887 (1), 16290928 (1), 17170385 (1), 2390021 (1) (see all 34)
astrocytoma	37.2	4	7875535 (1), 10415087 (1), 7521949 (1), 10753681 (1)
migraine	33.6	12	8536297 (2), 16472331 (1), 9399010 (1), 17222167 (1) (see all 6)
motility disorder	33	1	14670823 (1)
bronchitis chronic	32.1	1	12794061 (1)
serotonin syndrome	25.7	3	9637018 (2)
carcinoid	20	3	9296223 (1), 14713258 (1), 16556667 (1)
allergic rhinitis	14.4	1	10547475 (1)
pulmonary disease chronic obstructive	12.4	3	15707854 (2), 15544859 (1)

Genetic Association Database (GAD): TAC1
Human Genome Epidemiology (HuGE) Navigator: TAC1 (20 documents)

Export disorders for TAC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TAC1 gene, integrated from 10 sources (see all 931):
(articles sorted by number of sources associating them with TAC1)

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Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PubMed id 1708336)^{1, 2, 3} Chiwakata C....Ivell R. (Endocrinology 1991)
Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PubMed id 16503654)^{1, 2, 9} Dike A. and Cowsik S.M. (Biochemistry 2006)
Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PubMed id 2284201)^{1, 2, 9} McGregor G.P. and Conlon J.M. (Peptides 1990)
Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PubMed id 17655760)^{1, 4, 9} Mishra B.K....Max M.B. (Mol Pain 2007)
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)^{1, 4} Xu Y....Liu P. (Schizophr. Res. 2010)
Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PubMed id 20580442)^{1, 4} Klassert T.E....HernA!ndez M. (J. Neuroimmunol. 2010)
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)^{1, 4} Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PubMed id 20173430)^{1, 4} Herlyn P....Gradl G. (Clin J Pain 2010)
Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)^{1, 4} Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6863	HGNC: 11517	AceView: TAC1	Ensembl:ENSG00000006128	euGenes: HUgn6863
ECgene: TAC1	H-InvDB: TAC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TAC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TAC1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Neurokinin_1

Intellectual Property for TAC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TAC1 gene:
Search GeneIP for patents involving TAC1

GeneCards and IP:
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TAC1 Gene

Tachykinin, Precursor 1

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TAC1 (Gene Symbol)
Tachykinin, Precursor 1
NKNA
TAC2
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma)
Neurokinin 1
Neurokinin 2
Neurokinin Alpha
Neuromedin L
Neuropeptide Gamma
Neuropeptide K
preprotachykinin
Substance K
Substance P
PPT
Hs.2563
NK2
NPK
Neurokinin A
protachykinin-1
Tachykinin 2
NKA

major depression
Diseases Obstructive
Migraine
Autoimmune Diseases
BREAST CARCINOMA
Neurological Disorders
Colon Cancer
Serotonin syndrome
Cystitis
Parkinson Disease
Xerostomia
arthropathy
Glioma
Astrocytoma
Colitis Ulcerative
Allergic Reaction
Osteoarthritis
Skin Diseases
Airway Obstruction
Breast Cancer
Edema
Schizophrenia
Asthma
AIDS
Adenocarcinoma
Effects Cardiovascular
Carcinoid
Allergic rhinitis
psychological distress
Obstruction
Cancer
Bronchitis Chronic
Hypotension
Cancer Lung
small cell lung cancer
HEART FAILURE
Inflammatory Bowel Diseases
Neuroendocrine Tumors
Bronchoalveolar Lavage Fluid
motility disorder
Respiratory disease
Insulin Resistance
Inflammation
reflux
Cysts
psychiatric disorder
Pulmonary Disease Chronic Obstructive
Sarcoidosis
Rheumatoid Arthritis
Tumors
liver metastases
Metastasis
Necrosis
Lymphoblastic Leukemia Acute
Asthma allergic
Glioblastoma
Preeclampsia
Chronic Disease
Arthritis

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TAC1 Gene

Tachykinin, Precursor 1

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