Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TAC1 Gene

protein-coding GIFtS: 64
GCID: GC07P097361

tachykinin, precursor 1

(Previous names: tachykinin, precursor 1 (substance K, substance P, neurokinin...)
(Previous symbols: TAC2, NKNA)

Explore 106 diseases affiliated with
TAC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tachykinin, Precursor 1¹ ²		Neurokinin Alpha²
NKNA¹ ² ³ ⁵		Neuromedin L²
TAC2¹ ² ³ ⁵		Neuropeptide Gamma²
NPK¹ ²		Neuropeptide K²
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma)¹ ²		Protachykinin-1¹
PPT² ³		Substance K²
NK2²		Substance P²
Neurokinin 1²		Tachykinin 2²
Neurokinin 2²		NKA³
Neurokinin A²

External Ids:	HGNC: 11517¹	Entrez Gene: 6863²	Ensembl: ENSG00000006128⁷	OMIM: 162320⁵	UniProtKB: P20366³

Export aliases for TAC1 gene to outside databases

Previous GC identifers: GC07P095896 GC07P096959 GC07P096973 GC07P097006 GC07P097199 GC07P091962

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAC1:

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the

related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters

which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and

function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found

for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles

summary for TAC1:

The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins

have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins

have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1

has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main

tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TAC1 gene promoter:
Nkx2-5 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TAC1 promoter sequence

Search SABiosciences Chromatin IP Primers for TAC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21-q22

TAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P097361: view genomic region (about GC identifiers)

Start:	97,361,220 bp from pter	End:	97,369,784 bp from pter
Size:	8,565 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 96,683,759-96,692,272

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366 (See protein sequence)

Recommended Name: Protachykinin-1 precursor

Size: 129 amino acids; 15003 Da

Subcellular location: Secreted

4 PDB 3D structures from and Proteopedia for TAC1:

2B19 (3D)

2KS9 (3D)

2KSA (3D)

2KSB (3D)

Secondary accessions: O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1

Alternative splicing: 4 isoforms: P20366-1 P20366-2 P20366-3 P20366-4

Explore the universe of human proteins at neXtProt for TAC1: NX_P20366

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20366

TAC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_003173.1 NP_054702.1 NP_054703.1 NP_054704.1

ENSEMBL proteins:

ENSP00000321106 ENSP00000289576 ENSP00000289574

Reactome Protein details: P20366
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): TAC1 OriGene Custom Protein Services for TAC1
	GenScript Custom Purified and Recombinant Proteins Services for TAC1
	Novus Biologicals TAC1 Protein Novus Biologicals TAC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TAC1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0030424	axon	IEA	--
GO:0043025	neuronal cell body	IEA	--

TAC1 for ontologies About GeneDecksing

TAC1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TAC1
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TAC1 OriGene Custom Antibody Services for TAC1
	GenScript Custom Superior Antibodies Services for TAC1
	Novus Biologicals TAC1 Antibodies
	Abcam antibodies for TAC1
	Uscn Antibodies for TAC1
	ThermoFisher Antibodies for TAC1

Assay Products for TAC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TAC1
	Enzo Life Sciences assays for TAC1
	Uscn ELISAs and CLIAs for TAC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAC1 for domains About GeneDecksing

3 InterPro domains/families:

IPR008215 Tachykinin

IPR008216 Protachykinin

IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry P20366

ProtoNet protein and cluster: P20366

1 Blocks protein family: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Similarity: Belongs to the tachykinin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and

secretagogues, and contract (directly or indirectly) many smooth muscles

Genatlas biochemistry entry for TAC1:

tachykinin 1,neurokinin A (substance K) and substance P precursor gene

miRNA Products:		miRTarBase miRNAs that target TAC1: hsa-mir-320a (MIRT003003), hsa-mir-206 (MIRT003004), hsa-mir-130a (MIRT003005)

		OriGene 3'-UTR Clone (see all 4): TAC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAC1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAC1:
		hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: TAC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC1 (see all 7) OriGene shRNA RFP: TAC1 OriGene siRNA: TAC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TAC1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TAC1 (NM_003182)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TAC1
		Search LifeMap BioReagents cell lines for TAC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0031835	substance P receptor binding	IEA	--

TAC1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TAC1:

Decreased nuclei size in G2M

Animal Models:
Mouse knock-outs for TAC1: Tac1^tm1Bbm Tac1^tm1Pig
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tac1):

behavior/neurological

cardiovascular system

integument

renal/urinary system

TAC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Tachykinin receptors bind tachykinins

Tachykinin receptors bind tachykinins

1.00

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TAC1

	Selected targets of C/EBPbeta
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAC1

	Neuropathic Pain-Signaling in Dorsal Horn Neurons
	NK1R-mediated Non-Apoptotic PCD

1 BioSystems Pathway for TAC1

SIDS Susceptibility Pathways

5/9 Reactome Pathways for TAC1 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

TAC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TAC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/138 Interacting proteins for TAC1 (P20366^{2, 3} ENSP00000321106⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 138)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGEF40	Q8TER5²^,³, ENSP00000298694⁴	MINT-63551 I2D: score=4 STRING: ENSP00000298694
DPP4	P27487²^,³, ENSP00000353731⁴	MINT-8090912 I2D: score=1 STRING: ENSP00000353731
FAP	Q12884²^,³, ENSP00000188790⁴	MINT-8090748 I2D: score=1 STRING: ENSP00000188790
CENPB	P07199²^,³	MINT-8272520 I2D: score=2
XRCC6	P12956²^,³	MINT-8272531 I2D: score=2

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002675	positive regulation of acute inflammatory response	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	8957234
GO:0007217	tachykinin receptor signaling pathway	IEA	--
GO:0007218	neuropeptide signaling pathway	IEA	--

TAC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TAC1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TAC1 available from Tocris Bioscience About this table

Compound	Action	CAS #
MEN 10376	Potent, selective NK2 antagonist	[135306-85-3]
GR 64349	Potent, selective NK2 agonist	[137593-52-3]
GR 159897	Non-peptide, potent NK2 antagonist	[158848-32-9]
GR 94800	Potent, selective NK2 antagonist	[141636-65-9]
MEN 10627	Potent, selective NK2 antagonist	[157351-81-0]

10/147 Novoseek chemical compound relationships for TAC1 gene (see all 147) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
senktide	93.4	56	7544197 (5), 7824047 (3), 9543242 (2), 8864543 (2) (see all 28)
sr48968	91.2	29	7961636 (2), 18601911 (2), 11591520 (1), 14718265 (1) (see all 21)
nepadutant	88.6	11	16616700 (2), 11906947 (1), 15037522 (1), 11937105 (1) (see all 9)
fk 224	88.4	10	8665034 (2), 8726939 (1), 9302648 (1), 9243258 (1) (see all 6)
aprepitant	88	27	15973669 (2), 17722507 (1), 18719071 (1), 19148578 (1) (see all 21)
eledoisin	87.3	44	1708071 (3), 1712834 (2), 1719434 (2), 11245256 (1) (see all 22)
septide	86.3	42	9786514 (3), 8985159 (3), 8786533 (2), 10214937 (2) (see all 13)
fk 888	84.3	8	7889271 (2), 9302648 (1), 7534186 (1), 8529964 (1) (see all 7)
thiorphan	81.4	26	1317691 (4), 1690360 (2), 8214946 (2), 8256886 (2) (see all 16)
cyclo(gln-trp-phe-gly-leu-met)	80.1	8	7544197 (1), 14985054 (1), 1964226 (1), 1713430 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about TAC1 / TKN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAC1 gene (4 alternative transcripts):

NM_003182.2 NM_013996.2 NM_013997.2 NM_013998.2

Unigene Cluster for TAC1:

Tachykinin, precursor 1

Hs.2563 [show with all ESTs]

Unigene Representative Sequence: NM_003182

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000319273(uc003uop.4 uc003uoq.4 uc003uor.4 uc003uos.4)

ENST00000350485 ENST00000346867 ENST00000495916 ENST00000491437

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TAC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAC1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAC1:
		hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
		SwitchGear 3'UTR luciferase reporter plasmid: TAC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC1 (see all 7) OriGene shRNA RFP: TAC1 OriGene siRNA: TAC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): TAC1 (NM_003182)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TAC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC1

Additional cDNA sequence:

AF050655.1 AF050656.1 AF050657.1 AF050658.1 AK222957.1 BC018047.1 CR407602.1 CR541730.1

M68906.1 M68907.1 U37529.1 X54469.1

4 DOTS entries:

DT.110616 DT.86746127 DT.95163775 DT.121056930

24/43 AceView cDNA sequences (see all 43):

AF050657 AF050656 CR541730 AU105584 M68907 AF050655 CR407602 AA814651

AF050658 CD676459 BI599782 NM_003182 BQ719178 BG708147 CD676460 BG714365

BM712701 BI552074 AI277203 AU099398 BG708227 NM_013998 BQ446483 NM_013997

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTGACT

About this image

TAC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Gut Tube

Foregut

Foregut Endoderm Cells

Endoderm

Epicardium

Zeugopod Epiphyseal End

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TAC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAC1

SOURCE GeneReport for Unigene cluster: Hs.2563

SABiosciences Expression via Pathway-Focused PCR Array including TAC1:

Huntington's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TAC1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TAC1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Tac1^{1 , 5}	tachykinin 1^{1, 5}	93.54(n)¹ 95.35(a)¹	6 (3.31 cM)⁵ 21333¹ NM_009311.2¹ NP_033337.1¹ 7555071⁵
chicken (Gallus gallus)	Aves	TAC1¹	tachykinin, precursor 1	74.63(n) 70.8(a)	420573 XM_418674.3 XP_418674.2
zebrafish (Danio rerio)	Actinopterygii	CK363556.1²	--	71.74(n)	CK363556.1

ENSEMBL Gene Tree for TAC1 (if available)
TreeFam Gene Tree for TAC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111544432^1,2		--	97359304(+)	`GCAAAG/CTCCAG`	4	--	us2k¹		1		CSA	2
rs187534455^1,2		--	97359584(+)	`TCCTGC/TCATGT`	4	--	us2k¹		0	--	--	--	--
rs7793277^1,2	C,F,H,	--	97359585(+)	`cctgcC/Gatgtg`	4	--	us2k¹		18		NS EA NA CSA WA	2341
rs113808028^1,2	C,	--	97359686(+)	`TCCAAC/ACTTCG`	4	--	us2k¹		1		NA	2
rs183076921^1,2		--	97359691(+)	`CCTTCA/GAAACT`	4	--	us2k¹		0	--	--	--	--
rs188156763^1,2		--	97359714(+)	`TTTCTA/GTTGTT`	4	--	us2k¹		0	--	--	--	--
rs192437256^1,2		--	97359817(+)	`TAGTAA/TACTGT`	4	--	us2k¹		0	--	--	--	--
rs144251426^1,2		--	97359825(+)	`TGTGTC/GGGCCG`	4	--	us2k¹		0	--	--	--	--
rs2051794^1,2	C,F,H,	--	97359857(-)	`GCATTC/AAAATA`	4	--	us2k¹		14		NS EA NA CSA WA	1353
rs148711102^1,2		--	97359966(+)	`ACATGC/TTGAAA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TAC1 (97361220 - 97369784 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAC1
1 CNV: 1157

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAC1

DNA2.0 Custom Variant and Variant Library Synthesis for TAC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAC1 for disorders           About GeneDecksing

OMIM gene information: 162320    OMIM disorders: --

20/106 diseases for TAC1 (see all 106):    About MalaCards

sudden infant death syndrome complex regional pain syndrome carpal tunnel syndrome burning mouth syndrome

myofascial pain syndrome lichen planus motion sickness vasomotor rhinitis

oral lichen planus traumatic brain injury allergic rhinitis inflammatory bowel disease

uterine fibroid paine syndrome brain injury irritable bowel syndrome

chronic obstructive pulmonary disease sleep apnea insulin resistance epicondylitis

20/29 diseases from the University of Copenhagen DISEASES database for TAC1 (see all 29):

Pain agnosia Asthma Migraine Complex regional pain syndrome

Fibromyalgia Cystitis Rhinitis Dermatitis

Irritable bowel syndrome Arthritis Huntington's disease Constipation

Cholera Parkinson's disease Neuropathy Epicondylitis

Inflammatory bowel disease Diarrhea Hypertension Pain disorder

10/59 Novoseek disease relationships for TAC1 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	54.2	67	14749007 (6), 18507649 (5), 15707850 (4), 11991878 (3) (see all 32)
inflammation	54	42	9038887 (1), 16290928 (1), 17170385 (1), 2390021 (1) (see all 34)
astrocytoma	37.2	4	7875535 (1), 10415087 (1), 7521949 (1), 10753681 (1)
migraine	33.6	12	8536297 (2), 16472331 (1), 9399010 (1), 17222167 (1) (see all 6)
motility disorder	33	1	14670823 (1)
bronchitis chronic	32.1	1	12794061 (1)
serotonin syndrome	25.7	3	9637018 (2)
carcinoid	20	3	9296223 (1), 14713258 (1), 16556667 (1)
allergic rhinitis	14.4	1	10547475 (1)
pulmonary disease chronic obstructive	12.4	3	15707854 (2), 15544859 (1)

Genetic Association Database (GAD): TAC1
Human Genome Epidemiology (HuGE) Navigator: TAC1 (20 documents)

Export disorders for TAC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TAC1 gene, integrated from 9 sources (see all 920):
(articles sorted by number of sources associating them with TAC1)

Utopia: connect your pdf to the dynamic
world of online information

Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PubMed id 1708336)^{1, 2, 3} Chiwakata C....Ivell R. (1991)
Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PubMed id 16503654)^{1, 2, 9} Dike A. and Cowsik S.M. (2006)
Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PubMed id 2284201)^{1, 2, 9} McGregor G.P. and Conlon J.M. (1990)
Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis. (PubMed id 15729363)^{1, 4} Cunningham S....Vandenbroeck K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. (PubMed id 9846828)^{1, 2} Lai J.P.... Ho W.Z. (1998)
Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. (PubMed id 3038549)^{1, 2} Theodorsson-Norheim E.... Jacobsson G. (1987)
cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A. (PubMed id 3770210)^{1, 2} Harmar A.J.... Fink G. (1986)
[Change of neurokinin A plasma level in asthmatic children] (PubMed id 14749007)^{1, 9} Shang Y.X....Wei K.L. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6863	HGNC: 11517	AceView: TAC1	Ensembl:ENSG00000006128	euGenes: HUgn6863
ECgene: TAC1	H-InvDB: TAC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TAC1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Neurokinin_1

Intellectual Property for TAC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TAC1 gene:
Search GeneIP for patents involving TAC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TAC1
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TAC1		OriGene shRNA RFP for TAC1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAC1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAC1
	OriGene Protein Over-expression Lysate for TAC1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TAC1		OriGene 3'-UTR Clone for TAC1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAC1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TAC1		OriGene Custom Protein Services for TAC1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAC1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAC1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAC1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAC1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAC1

	GenScript Custom Purified and Recombinant Proteins Services for TAC1		GenScript cDNA clones with any tag delivered in your preferred vector for TAC1
	GenScript Custom Assay Services for TAC1		GenScript Custom Superior Antibodies Services for TAC1
	GenScript Custom overexpressing Cell Line Services for TAC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TAC1 promoter
	Search Chromatin IP Primers for TAC1
	RT² qPCR Primer Assay in human, mouse, rat TAC1
	GNC Network for TAC1
	SABiosciences PCR Arrays including human, mouse, rat TAC1

Tocris compounds for TAC1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays for TAC1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TAC1 antibodies
	TAC1 proteins
	TAC1 lysates

	Antibodies for TAC1
	See all of Abcam's Antibodies, Kits and Proteins for TAC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TAC1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TAC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

	SwitchGear 3'UTR luciferase reporter plasmids for TAC1
	SwitchGear Promoter luciferase reporter plasmids for TAC1

ThermoFisher Antibodies for TAC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TAC1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TAC1 Gene

tachykinin, precursor 1

Aliases
for TAC1 gene

Summaries
for TAC1 gene

Genomic Views
for TAC1 gene

Proteins
for TAC1 gene

Protein Domains /
Families
for TAC1 gene

Function
for TAC1 gene

Pathways & Interactions
for TAC1 gene

Drugs & Compounds
for TAC1 gene

Transcripts
for TAC1 gene

Expression
for TAC1 gene

Orthologs
for TAC1 gene

Paralogs
for TAC1 gene

Genomic Variants
for TAC1 gene

Disorders / Diseases
for TAC1 gene

Publications
for TAC1 gene

External Searches for TAC1 gene

Genome Databases showing TAC1 gene

Other Databases showing TAC1 gene

Specialized Databases showing TAC1 gene

Intellectual Property
for TAC1 gene

Products
for TAC1 gene

View Random Gene

TAC1 (Gene Symbol)
Tachykinin, Precursor 1
NKNA
TAC2
NPK
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma)
PPT
Hs.2563
NK2
Neurokinin 1
Neurokinin 2
Neurokinin A
Neurokinin Alpha
Neuromedin L
Neuropeptide Gamma
Neuropeptide K
Protachykinin-1
Substance K
Substance P
Tachykinin 2
NKA

major depression
Diseases Obstructive
Migraine
Autoimmune Diseases
BREAST CARCINOMA
Neurological Disorders
Colon Cancer
Serotonin syndrome
Cystitis
Parkinson Disease
Xerostomia
arthropathy
Glioma
Astrocytoma
Colitis Ulcerative
Allergic Reaction
Osteoarthritis
Skin Diseases
Airway Obstruction
Breast Cancer
Edema
Schizophrenia
Asthma
AIDS
Adenocarcinoma
Effects Cardiovascular
Carcinoid
Allergic rhinitis
psychological distress
Obstruction
Cancer
Bronchitis Chronic
Hypotension
Cancer Lung
small cell lung cancer
HEART FAILURE
Inflammatory Bowel Diseases
Neuroendocrine Tumors
Bronchoalveolar Lavage Fluid
motility disorder
Respiratory disease
Insulin Resistance
Inflammation
reflux
Cysts
psychiatric disorder
Pulmonary Disease Chronic Obstructive
Sarcoidosis
Rheumatoid Arthritis
Tumors
liver metastases
Metastasis
Necrosis
Lymphoblastic Leukemia Acute
Asthma allergic
Glioblastoma
Preeclampsia
Chronic Disease
Arthritis

Advanced Search

Export list of displayed genes

TAC1 Gene

tachykinin, precursor 1

Aliasesfor TAC1 gene

Summariesfor TAC1 gene

Genomic Viewsfor TAC1 gene

Proteinsfor TAC1 gene

Protein Domains /Familiesfor TAC1 gene

Functionfor TAC1 gene

Pathways & Interactionsfor TAC1 gene

Drugs & Compoundsfor TAC1 gene

Transcriptsfor TAC1 gene

Expression for TAC1 gene

Orthologsfor TAC1 gene

Paralogsfor TAC1 gene

Genomic Variantsfor TAC1 gene

Disorders / Diseasesfor TAC1 gene

Publicationsfor TAC1 gene

External Searches for TAC1 gene

Genome Databases showing TAC1 gene

Other Databases showing TAC1 gene

Specialized Databases showing TAC1 gene

Intellectual Propertyfor TAC1 gene

Productsfor TAC1 gene

View Random Gene

Aliases
for TAC1 gene

Summaries
for TAC1 gene

Genomic Views
for TAC1 gene

Proteins
for TAC1 gene

Protein Domains /
Families
for TAC1 gene

Function
for TAC1 gene

Pathways & Interactions
for TAC1 gene

Drugs & Compounds
for TAC1 gene

Transcripts
for TAC1 gene

Expression
for TAC1 gene

Orthologs
for TAC1 gene

Paralogs
for TAC1 gene

Genomic Variants
for TAC1 gene

Disorders / Diseases
for TAC1 gene

Publications
for TAC1 gene

Intellectual Property
for TAC1 gene

Products
for TAC1 gene