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TAC1 Gene(Protein Coding)

Tachykinin Precursor 1

GCID:
GC07P097731
GIFtS:
64
Genes Participants
UDN Logo

Aliases for TAC1 Gene

Aliases for TAC1 Gene

  • Tachykinin Precursor 1 2 3 5
  • Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, Neuropeptide Gamma) 2 3
  • Neuropeptide Gamma 2 3
  • Neurokinin Alpha 2 3
  • Preprotachykinin 2 3
  • Neuropeptide K 2 3
  • Protachykinin 2 3
  • Neurokinin 1 2 3
  • Neurokinin 2 2 3
  • Neuromedin L 2 3
  • Substance K 2 3
  • Substance P 2 3
  • NKNA 3 4
  • TAC2 3 4
  • PPT 3 4
  • Neurokinin A 3
  • Tachykinin 2 3
  • Hs.2563 3
  • NK2 3
  • NPK 3
  • NKA 4

External Ids for TAC1 Gene

Previous HGNC Symbols for TAC1 Gene

  • TAC2
  • NKNA

Previous GeneCards Identifiers for TAC1 Gene

  • GC07P095896
  • GC07P096959
  • GC07P096973
  • GC07P097006
  • GC07P097199
  • GC07P097361
  • GC07P091962

Summaries for TAC1 Gene

Entrez Gene Summary for TAC1 Gene

  • This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for TAC1 Gene

TAC1 (Tachykinin Precursor 1) is a Protein Coding gene. Diseases associated with TAC1 include Neurotrophic Keratopathy and Constipation. Among its related pathways are Peptide ligand-binding receptors and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot for TAC1 Gene

  • Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Tocris Summary for TAC1 Gene

  • The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAC1 Gene

Genomics for TAC1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TAC1 Gene

Enhancers for TAC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAC1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TAC1 gene promoter:

Genomic Location for TAC1 Gene

Chromosome:
7
Start:
97,731,908 bp from pter
End:
97,740,472 bp from pter
Size:
8,565 bases
Orientation:
Plus strand

Genomic View for TAC1 Gene

Genes around TAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TAC1 Gene

Proteins for TAC1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20366-TKN1_HUMAN
    Recommended name:
    Protachykinin-1
    Protein Accession:
    P20366
    Secondary Accessions:
    • O60600
    • O60601
    • Q00072
    • Q53GH4
    • Q549V0
    • Q549V1
    • Q549V2
    • Q6FHM1

    Protein attributes for TAC1 Gene

    Size:
    129 amino acids
    Molecular mass:
    15003 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TAC1 Gene

    Alternative splice isoforms for TAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAC1 Gene

Proteomics data for TAC1 Gene at MOPED

Protein Expression for TAC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TAC1 Gene

  • The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAC1 Gene

Domains & Families for TAC1 Gene

Gene Families for TAC1 Gene

HGNC:

Protein Domains for TAC1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20366

UniProtKB/Swiss-Prot:

TKN1_HUMAN :
  • Belongs to the tachykinin family.
Family:
  • Belongs to the tachykinin family.
genes like me logo Genes that share domains with TAC1: view

Function for TAC1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for TAC1 Gene

GENATLAS Biochemistry:
tachykinin 1,neurokinin A (substance K) and substance P precursor gene
UniProtKB/Swiss-Prot Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Phenotypes for TAC1 Gene

MGI mutant phenotypes for TAC1:
inferred from 3 alleles
GenomeRNAi human phenotypes for TAC1:
genes like me logo Genes that share phenotypes with TAC1: view

Animal Models for TAC1 Gene

MGI Knock Outs for TAC1:

miRNA for TAC1 Gene

miRTarBase miRNAs that target TAC1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAC1 Gene

Localization for TAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAC1 Gene COMPARTMENTS Subcellular localization image for TAC1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
endosome 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TAC1 Gene

Pathways & Interactions for TAC1 Gene

genes like me logo Genes that share pathways with TAC1: view

SIGNOR curated interactions for TAC1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IDA 18603306
GO:0006954 inflammatory response IBA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8957234
GO:0007217 tachykinin receptor signaling pathway IEA,IBA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with TAC1: view

Drugs & Compounds for TAC1 Gene

Products:

  1. Drug

(92) Drugs for TAC1 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fosaprepitant Approved Pharma Neurokinin-1 antagonist 155
Fosaprepitant dimeglumine salt Pharma Neurokinin-1 antagonist 0

(62) Additional Compounds for TAC1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[bAla8]-Neurokinin A(4-10)
122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10)
137565-28-7
GR 159897
158848-32-9
GR 64349
137593-52-3
MDL 29,913
135721-56-1

(5) Tocris Compounds for TAC1 Gene

Compound Action Cas Number
[bAla8]-Neurokinin A(4-10) NK2 agonist 122063-01-8
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist 137565-28-7
GR 159897 Non-peptide, potent NK2 antagonist 158848-32-9
GR 64349 Potent, selective NK2 agonist 137593-52-3
MDL 29,913 Selective NK2 antagonist 135721-56-1

(2) ApexBio Compounds for TAC1 Gene

Compound Action Cas Number
Fosaprepitant Neurokinin-1 antagonist 172673-20-0
Fosaprepitant dimeglumine salt Neurokinin-1 antagonist 265121-04-8
genes like me logo Genes that share compounds with TAC1: view

Transcripts for TAC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TAC1 Gene

(4) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAC1 Gene

Tachykinin, precursor 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAC1 Gene

No ASD Table

Relevant External Links for TAC1 Gene

GeneLoc Exon Structure for
TAC1
ECgene alternative splicing isoforms for
TAC1

Expression for TAC1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TAC1 Gene

mRNA expression in normal human tissues for TAC1 Gene
mRNA expression by BioGPS for TAC1 GenemRNA expression by GTEx for TAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAC1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x12.5), Brain - Putamen (basal ganglia) (x11.9), and Brain - Nucleus accumbens (basal ganglia) (x8.5).

Protein differential expression in normal tissues from HIPED for TAC1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAC1 Gene



SOURCE GeneReport for Unigene cluster for TAC1 Gene Hs.2563

genes like me logo Genes that share expression patterns with TAC1: view

Protein tissue co-expression partners for TAC1 Gene

- Elite partner

No data available for mRNA Expression by UniProt/SwissProt for TAC1 Gene

Orthologs for TAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TAC1 35
  • 93.28 (n)
  • 91.47 (a)
TAC1 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TAC1 35
  • 96.12 (n)
  • 99.22 (a)
TAC1 36
  • 95 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tac1 35
  • 93.54 (n)
  • 95.35 (a)
Tac1 16
Tac1 36
  • 95 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TAC1 35
  • 99.48 (n)
  • 98.45 (a)
TAC1 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tac1 35
  • 93.02 (n)
  • 96.9 (a)
oppossum
(Monodelphis domestica)
 Mammalia TAC1 36
  • 81 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TAC1 36
  • 42 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TAC1 35
  • 74.63 (n)
  • 70.8 (a)
TAC1 36
  • 65 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TAC1 36
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tac1 35
  • 71.07 (n)
  • 63.21 (a)
zebrafish
(Danio rerio)
 Actinopterygii tac1 35
  • 62.76 (n)
  • 47.75 (a)
tac1 36
  • 42 (a)
 OneToOne
Species with no ortholog for TAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAC1 Gene

ENSEMBL:
Gene Tree for TAC1 (if available)
TreeFam:
Gene Tree for TAC1 (if available)

Paralogs for TAC1 Gene

No data available for Paralogs for TAC1 Gene

Variants for TAC1 Gene

Sequence variations from dbSNP and Humsavar for TAC1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1229434 -- 97,736,530(-) TGGTA(A/G)TATTA intron-variant
rs1397202 -- 97,739,695(+) TTCCA(A/G)TCAGA intron-variant
rs1510300 -- 97,739,437(+) AACCT(C/G)TTTAC intron-variant
rs6971011 -- 97,732,532(+) CTTTA(A/C)CTCTT intron-variant
rs6971427 -- 97,732,556(+) TAATA(G/T)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAC1 Gene

Variant ID Type Subtype PubMed ID
nsv888757 CNV Gain 21882294
nsv888759 CNV Gain 21882294
nsv437559 CNV Loss 16327808

Variation tolerance for TAC1 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAC1 Gene

Disorders for TAC1 Gene

MalaCards: The human disease database

(49) MalaCards diseases for TAC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurotrophic keratopathy
  • neurotrophic keratitis
constipation
bronchitis
  • acute bronchitis
rhinitis
  • runny nose
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search TAC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAC1

Genetic Association Database (GAD)
TAC1
Human Genome Epidemiology (HuGE) Navigator
TAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAC1
genes like me logo Genes that share disorders with TAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAC1 Gene

Publications for TAC1 Gene

  1. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PMID: 1708336) Chiwakata C. … Ivell R. (Endocrinology 1991) 2 3 4 67
  2. Tac1 regulation by RNA-binding protein and miRNA in bone marrow stroma: Implication for hematopoietic activity. (PMID: 18061399) Murthy R.G. … Rameshwar P. (Brain Behav. Immun. 2008) 3 23
  3. Stromal-derived factor-1alpha induces a non-canonical pathway to activate the endocrine-linked Tac1 gene in non-tumorigenic breast cells. (PMID: 18316470) Corcoran K.E. … Rameshwar P. (J. Mol. Endocrinol. 2008) 3 23
  4. Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity. (PMID: 18507649) Mostafa G.A. … Ahmed S.A. (Allergy 2008) 3 23
  5. Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor. (PMID: 18990442) Howard M.R. … Quinn J.P. (Neuropeptides 2008) 3 23

Products for TAC1 Gene

  • Addgene plasmids for TAC1

Sources for TAC1 Gene

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