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TAC1 Gene

protein-coding   GIFtS: 61
GCID: GC07P097361

Tachykinin, Precursor 1

(Previous names: tachykinin, precursor 1 (substance K, substance P, neurokinin...)
(Previous symbols: TAC2, NKNA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tachykinin, Precursor 11 2     preprotachykinin1 2
NKNA1 2 3 5     Substance K1 2
TAC21 2 3 5     Substance P1 2
Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1,
Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K,
Neuropeptide Gamma)1 2
     PPT2 3
Neurokinin 11 2     NK22
Neurokinin 21 2     NPK2
Neurokinin Alpha1 2     Neurokinin A2
Neuromedin L1 2     protachykinin-12
Neuropeptide Gamma1 2     Tachykinin 22
Neuropeptide K1 2     NKA3

External Ids:    HGNC: 115171   Entrez Gene: 68632   Ensembl: ENSG000000061287   OMIM: 1623205   UniProtKB: P203663   

Export aliases for TAC1 gene to outside databases

Previous GC identifers: GC07P095896 GC07P096959 GC07P096973 GC07P097006 GC07P097199 GC07P091962


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAC1 Gene:
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as
the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as
neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce
behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAC1 Gene:
TAC1 (tachykinin, precursor 1) is a protein-coding gene. Diseases associated with TAC1 include neurotrophic keratopathy, and prurigo nodularis. GO annotations related to this gene include substance P receptor binding.

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

summary for TAC1 Gene:
The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins
have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins
have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1
has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main
tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Gene Wiki entry for TAC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAC1 gene promoter:
         Nkx2-5   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TAC1 promoter sequence
   Search Chromatin IP Primers for TAC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21-q22

TAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAC1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P097361:  view genomic region     (about GC identifiers)

Start:
97,361,220 bp from pter      End:
97,369,784 bp from pter
Size:
8,565 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 96,683,759-96,692,272     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366 (See protein sequence)
Recommended Name: Protachykinin-1 precursor  
Size: 129 amino acids; 15003 Da
4 PDB 3D structures from and Proteopedia for TAC1:
2B19 (3D)        2KS9 (3D)        2KSA (3D)        2KSB (3D)    
Secondary accessions: O60600 O60601 Q00072 Q53GH4 Q549V0 Q549V1 Q549V2 Q6FHM1
Alternative splicing: 4 isoforms:  P20366-1   P20366-2   P20366-3   P20366-4   

Explore the universe of human proteins at neXtProt for TAC1: NX_P20366

Explore proteomics data for TAC1 at MOPED


See TAC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_003173.1  NP_054702.1  NP_054703.1  NP_054704.1  

ENSEMBL proteins: 
 ENSP00000321106   ENSP00000289576   ENSP00000289574  
Reactome Protein details: P20366

TAC1 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for TAC1

TAC1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of TAC1
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LSBio Antibodies in human, mouse, rat for TAC1

TAC1 Assay Products:

Browse Kits and Assays available from EMD Millipore
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Enzo Life Sciences assays for TAC1
Cloud-Clone Corp. ELISAs for TAC1
Cloud-Clone Corp. CLIAs for TAC1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR008215 Tachykinin
 IPR008216 Protachykinin
 IPR013055 Tachy_Neuro_lke_CS

Graphical View of Domain Structure for InterPro Entry P20366

ProtoNet protein and cluster: P20366

1 Blocks protein domain: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366
Similarity: Belongs to the tachykinin family


TAC1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TKN1_HUMAN, P20366
Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent
vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

     Genatlas biochemistry entry for TAC1:
tachykinin 1,neurokinin A (substance K) and substance P precursor gene

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
GO:0031835substance P receptor binding IEA--
     
TAC1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TAC1:
 Decreased nuclei size in G2M 

     5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tac1):
 behavior/neurological  cardiovascular system  integument  normal  renal/urinary system 

TAC1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TAC1: Tac1tm1Bbm Tac1tm1Pig

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAC1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAC1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAC1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAC1

miRNA
Products:
    
miRTarBase miRNAs that target TAC1:
hsa-mir-302a-3p (MIRT020344), hsa-mir-320a (MIRT003003), hsa-mir-206 (MIRT003004), hsa-mir-130a-3p (MIRT003005)

Block miRNA regulation of human, mouse, rat TAC1 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate TAC1:
hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
SwitchGear 3'UTR luciferase reporter plasmidTAC1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TAC1
Predesigned siRNA for gene silencing in human, mouse, rat TAC1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for TAC1

Clone
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OriGene clones in human, mouse for TAC1 (see all 24)
OriGene ORF clones in mouse, rat for TAC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): TAC1 (NM_003182)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC1

Cell Line
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GenScript Custom overexpressing Cell Line Services for TAC1
Browse ESI BIO Cell Lines and PureStem Progenitors for TAC1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TKN1_HUMAN, P20366: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus3
cytoskeleton2
mitochondrion2
plasma membrane2
cytosol1
endoplasmic reticulum1
endosome1
golgi apparatus1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005886plasma membrane IEA--
GO:0030424axon IEA--
GO:0043025neuronal cell body IEA--

TAC1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TAC1 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
Tachykinin receptors bind tachykinins0.00
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Neuropathic Pain-Signaling in Dorsal Horn Neurons
Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47
5Neuropeptides signaling through G protein alpha i and G protein alpha q
Neuropeptides signaling through G protein alpha i and G protein alpha q0.46

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAC1
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
NK1R-mediated Non-Apoptotic PCD

1 BioSystems Pathway for TAC1
    SIDS Susceptibility Pathways

2 Reactome Pathways for TAC1
    Tachykinin receptors bind tachykinins
G alpha (q) signalling events



TAC1 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including TAC1: 
          Huntington's Disease in human mouse rat

Interactions:

    GeneGlobe Interaction Network for TAC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TAC1 (P203661, 2, 3 ENSP000003211064) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000096155P463792, 3MINT-63550 I2D: score=5 
ENSG00000227761P463792, 3MINT-63550 I2D: score=5 
ENSG00000228760P463792, 3MINT-63550 I2D: score=5 
ENSG00000229524P463792, 3MINT-63550 I2D: score=5 
ENSG00000233348P463792, 3MINT-63550 I2D: score=5 
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Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002675positive regulation of acute inflammatory response IEA--
GO:0006954inflammatory response IEA--
GO:0007204positive regulation of cytosolic calcium ion concentration IDA8957234
GO:0007217tachykinin receptor signaling pathway IEA--
GO:0007218neuropeptide signaling pathway IEA--

TAC1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for TAC1 available from Tocris Bioscience    About this table
CompoundAction CAS #
MEN 10376 Potent, selective NK2 antagonist [135306-85-3]
GR 64349 Potent, selective NK2 agonist [137593-52-3]
GR 159897 Non-peptide, potent NK2 antagonist [158848-32-9]
[Lys5,MeLeu9,Nle10]-NKA(4-10) Selective NK2 agonist[137565-28-7]
GR 94800 Potent, selective NK2 antagonist [141636-65-9]

Selected Novoseek inferred chemical compound relationships for TAC1 gene (see all 147)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
senktide 93.4 56 7544197 (5), 7824047 (3), 9543242 (2), 8864543 (2) (see all 28)
sr48968 91.2 29 7961636 (2), 18601911 (2), 11591520 (1), 14718265 (1) (see all 21)
nepadutant 88.6 11 16616700 (2), 11906947 (1), 15037522 (1), 11937105 (1) (see all 9)
fk 224 88.4 10 8665034 (2), 8726939 (1), 9302648 (1), 9243258 (1) (see all 6)
aprepitant 88 27 15973669 (2), 17722507 (1), 18719071 (1), 19148578 (1) (see all 21)
eledoisin 87.3 44 1708071 (3), 1712834 (2), 1719434 (2), 11245256 (1) (see all 22)
septide 86.3 42 9786514 (3), 8985159 (3), 8786533 (2), 10214937 (2) (see all 13)
fk 888 84.3 8 7889271 (2), 9302648 (1), 7534186 (1), 8529964 (1) (see all 7)
thiorphan 81.4 26 1317691 (4), 1690360 (2), 8214946 (2), 8256886 (2) (see all 16)
cyclo(gln-trp-phe-gly-leu-met) 80.1 8 7544197 (1), 14985054 (1), 1964226 (1), 1713430 (1) (see all 5)



TAC1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TAC1 gene (4 alternative transcripts): 
NM_003182.2  NM_013996.2  NM_013997.2  NM_013998.2  

Unigene Cluster for TAC1:

Tachykinin, precursor 1
Hs.2563  [show with all ESTs]
Unigene Representative Sequence: NM_003182
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000319273(uc003uop.4 uc003uoq.4 uc003uor.4 uc003uos.4)
ENST00000350485 ENST00000346867 ENST00000495916 ENST00000491437
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Block miRNA regulation of human, mouse, rat TAC1 using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate TAC1:
hsa-miR-338-5p hsa-miR-494 hsa-miR-1271 hsa-miR-944 hsa-miR-218 hsa-miR-96 hsa-miR-636
SwitchGear 3'UTR luciferase reporter plasmidTAC1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TAC1
Predesigned siRNA for gene silencing in human, mouse, rat TAC1
Clone
Products:
     
OriGene clones in human, mouse for TAC1 (see all 24)
OriGene ORF clones in mouse, rat for TAC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): TAC1 (NM_003182)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAC1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAC1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TAC1
OriGene qSTAR qPCR primer pairs in human, mouse for TAC1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAC1
  QuantiTect SYBR Green Assays in human, mouse, rat TAC1
  QuantiFast Probe-based Assays in human, mouse, rat TAC1

Additional mRNA sequence: 

AF050655.1 AF050656.1 AF050657.1 AF050658.1 AK222957.1 BC018047.1 CR407602.1 CR541730.1 
M68906.1 M68907.1 U37529.1 X54469.1 

4 DOTS entries:

DT.110616  DT.86746127  DT.95163775  DT.121056930 

Selected AceView cDNA sequences (see all 43):

CR407602 AF050655 AU105584 M68907 AF050658 CR541730 AF050656 AF050657 
CD676459 AA814651 NM_013998 NM_003182 BG708227 AU099398 AI277203 NM_013997 
BC018047 BM921140 BG714365 BI599782 BQ446483 AW340043 CD676460 U37529 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TAC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTGTGACT
TAC1 Expression
About this image


TAC1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 12) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Zeugopod Epiphyseal End
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         GABAergic Amacrine Cells Inner Nuclear Layer
 
 Neurons
         GABAergic Amacrine Cells Inner Nuclear Layer
 
 Neural Ectoderm (Nervous System)
         Neural ectoderm cells
 
 Cartilage (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced MEL2 cells
TAC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TAC1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.2563
    Pathway & Disease-focused RT2 Profiler PCR Array including TAC1: 
          Huntington's Disease in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TAC1
OriGene qSTAR qPCR primer pairs in human, mouse for TAC1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAC1
QuantiTect SYBR Green Assays in human, mouse, rat TAC1
QuantiFast Probe-based Assays in human, mouse, rat TAC1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAC1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TAC1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tac11 , 5 tachykinin 11, 5 93.54(n)1
95.35(a)1
  6 (3.31 cM)5
213331  NM_009311.21  NP_033337.11 
 75548795 
chicken
(Gallus gallus)
Aves TAC11 tachykinin, precursor 1 74.63(n)
70.8(a)
  420573  XM_418674.4  XP_418674.2 
lizard
(Anolis carolinensis)
Reptilia TAC16
tachykinin, precursor 1
69(a)
1 ↔ 1
6(23493962-23520571)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tac11 tachykinin, precursor 1 71.07(n)
63.21(a)
  779508  NM_001172286.1  NP_001165757.1 
zebrafish
(Danio rerio)
Actinopterygii CK363556.12   -- 71.74(n)    CK363556.1 


ENSEMBL Gene Tree for TAC1 (if available)
TreeFam Gene Tree for TAC1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TAC1 (see all 193)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1115444321,2
F--97359304(+) GCAAAG/CTCCAG 4 -- us2k11Minor allele frequency- C:0.50CSA 2
rs1875344551,2
--97359584(+) TCCTGC/TCATGT 4 -- us2k10--------
rs77932771,2
C,F,H--97359585(+) cctgcC/Gatgtg 4 -- us2k118Minor allele frequency- G:0.23NS EA NA CSA WA 2341
rs1138080281,2
C,F--97359686(+) TCCAAC/ACTTCG 4 -- us2k11Minor allele frequency- A:0.50NA 2
rs1830769211,2
--97359691(+) CCTTCA/GAAACT 4 -- us2k10--------
rs1881567631,2
--97359714(+) TTTCTA/GTTGTT 4 -- us2k10--------
rs1924372561,2
--97359817(+) TAGTAA/TACTGT 4 -- us2k10--------
rs1442514261,2
--97359825(+) TGTGTC/GGGCCG 4 -- us2k10--------
rs20517941,2
C,F,H--97359857(-) gcattC/Aaaata 4 -- us2k114Minor allele frequency- A:0.06NS EA NA CSA WA 1353
rs1487111021,2
C--97359966(+) ACATGC/TTGAAA 4 -- us2k10--------

HapMap Linkage Disequilibrium report for TAC1 (97361220 - 97369784 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TAC1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv437559CNV Loss16327808
nsv888759CNV Gain21882294
nsv888757CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 162320    OMIM disorders: --

Selected diseases for TAC1 (see all 112):    
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neurotrophic keratopathy    prurigo nodularis    myofascial pain syndrome    epicondylitis
aspiration pneumonia    vasomotor rhinitis    alternating hemiplegia of childhood    pain disorder
motion sickness    burning mouth syndrome    burns    bronchitis
carpal tunnel syndrome    complex regional pain syndrome    paine syndrome    hemiplegia
gastrointestinal system disease    cryptosporidiosis    constipation    cystitis

Selected diseases from the University of Copenhagen DISEASES database for TAC1 (see all 30):
Pain agnosia     Asthma     Migraine     Complex regional pain syndrome
Rhinitis     Cystitis     Fibromyalgia     Dermatitis
Arthritis     Irritable bowel syndrome     Huntington's disease     Constipation
Neuropathy     Cholera     Parkinson's disease     Epicondylitis
Inflammatory bowel disease     Diarrhea     Hypertension     Pain disorder

TAC1 for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for TAC1 gene (see all 59)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
asthma 54.2 67 14749007 (6), 18507649 (5), 15707850 (4), 11991878 (3) (see all 32)
inflammation 54 42 9038887 (1), 16290928 (1), 17170385 (1), 2390021 (1) (see all 34)
astrocytoma 37.2 4 7875535 (1), 10415087 (1), 7521949 (1), 10753681 (1)
migraine 33.6 12 8536297 (2), 16472331 (1), 9399010 (1), 17222167 (1) (see all 6)
motility disorder 33 1 14670823 (1)
bronchitis chronic 32.1 1 12794061 (1)
serotonin syndrome 25.7 3 9637018 (2)
carcinoid 20 3 9296223 (1), 14713258 (1), 16556667 (1)
allergic rhinitis 14.4 1 10547475 (1)
pulmonary disease chronic obstructive 12.4 3 15707854 (2), 15544859 (1)

Genetic Association Database (GAD): TAC1
Human Genome Epidemiology (HuGE) Navigator: TAC1 (20 documents)

Export disorders for TAC1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TAC1 gene, integrated from 10 sources (see all 931):
(articles sorted by number of sources associating them with TAC1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PubMed id 1708336)1, 2, 3 Chiwakata C....Ivell R. (Endocrinology 1991)
  2. Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PubMed id 16503654)1, 2, 9 Dike A. and Cowsik S.M. (Biochemistry 2006)
  3. Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PubMed id 2284201)1, 2, 9 McGregor G.P. and Conlon J.M. (Peptides 1990)
  4. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? (PubMed id 17655760)1, 4, 9 Mishra B.K....Max M.B. (Mol Pain 2007)
  5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (Schizophr. Res. 2010)
  6. Common variants of the neuropeptide expressing tachykinin genes and susceptibility to asthma: a case-control study. (PubMed id 20580442)1, 4 Klassert T.E....HernA!ndez M. (J. Neuroimmunol. 2010)
  7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  8. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. (PubMed id 20173430)1, 4 Herlyn P....Gradl G. (Clin J Pain 2010)
  9. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6863 HGNC: 11517 AceView: TAC1 Ensembl:ENSG00000006128 euGenes: HUgn6863
ECgene: TAC1 H-InvDB: TAC1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TAC1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TAC1 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Neurokinin_1

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TAC1 gene:
Search GeneIP for patents involving TAC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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