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TAC1 Gene

protein-coding GIFtS: 62

GC07P097199

tachykinin, precursor 1
(Previous names: tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TAC2, NKNA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NK2 ^²
NKA ^³
NKNA ^², ³, ⁵
NPK ^¹, ²
PPT ^³
TAC2 ^², ³, ⁵

Descriptions
neurokinin 1 ^²
neurokinin 2 ^²
neurokinin A ^²
neurokinin alpha ^²
neuromedin L ^²
neuropeptide K ^²
neuropeptide gamma ^²
substance K ^²
substance P ^²
tachykinin 1 ^²
tachykinin 2 ^²
tachykinin, precursor 1 ^²
tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) ^¹, ²

External Ids
HGNC: 11517¹
Entrez Gene: 6863²
UniProtKB: P20366³
Ensembl: ENSG00000006128⁷

Search outside databases for aliases for TAC1 gene

Previous GC identifers: GC07P095896 GC07P096959 GC07P096973 GC07P097006

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAC1:

This gene encodes four products of the tachykinin peptide hormone family, substance P and

neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These

hormones are thought to function as neurotransmitters which interact with nerve receptors and

smooth muscle cells. They are known to induce behavioral responses and function as vasodilators

and secretagogues. Multiple transcript variants encoding different isoforms have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are

potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Gene Wiki entry for TAC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAC1 gene

Entrez Gene cytogenetic band: 7q21-q22 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21-q22

TAC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P097199: (about GC identifiers)

Start:	97,199,311 bp from pter
End:	97,207,720 bp from pter
Size:	8,410 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 96,683,863-96,692,272

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366 (See protein sequence)

Recommended Name: Protachykinin-1 precursor

Size: 129 amino acids; 15003 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

2B19 (3D)

Secondary accessions: O60600 O60601 Q00072 Q53GH4

Alternative splicing: 4 isoforms: P20366-1 P20366-2 P20366-3 P20366-4

REFSEQ proteins (4 alternative transcripts):

NP_003173.1 NP_054702.1 NP_054703.1 NP_054704.1

ENSEMBL proteins:

ENSP00000289574 ENSP00000289576 ENSP00000321106

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TAC1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Substance P, Neurokinin A)
	Human Recombinant Proteins from Abnova (TAC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	9548509
GO:0030424	axon	IEA	--
GO:0043025	cell soma	IEA	--

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Antibodies for TAC1:

	Invitrogen Antibodies for TAC1
	Millipore Mono- and Polyclonal Antibodies for the study of TAC1
	Sigma-Aldrich Antibodies for TAC1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Substance P, Neurokinin A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TAC1)
	Novus Biologicals Antibody for TAC1

Assays for TAC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20366

ProtoNet protein and cluster: P20366

1 Blocks protein family: IPB002040 Tachykinin/Neurokinin

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Similarity: Belongs to the tachykinin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003182

Applied Biosystems Silencer® siRNAs for TAC1

Sigma-Aldrich siRNA for TAC1

Sigma-Aldrich shRNA Panels and shRNA for TAC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TAC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_003182
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_003182
untagged cDNA clones in CMV expression vector (see all 4): NM_003182

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003182

UniProtKB/Swiss-Prot: TKN1_HUMAN, P20366

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are

potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles

Genatlas biochemistry entry for TAC1:

tachykinin 1,neurokinin A (substance K) and substance P precursor gene

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tac1):

behavior/neurological

renal/urinary system

touch/vibrissae

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TAC1 (Your Favorite Gene powered by Ingenuity)

Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks TAC1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TAC1

5/27 Interacting proteins for TAC1 (P20366² ENSP00000321106³) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAT3	P46379²	MINT-63550
FLJ10357	Q8TER5²	MINT-63551
TACR1	ENSP00000303522³	STRING (score=.999)
TACR2	ENSP00000362403³	STRING (score=.999)
TACR3	ENSP00000303325³	STRING (score=.993)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	8957234
GO:0007217	tachykinin receptor signaling pathway	IEA	--
GO:0007218	neuropeptide signaling pathway	IEA	--
GO:0007268	synaptic transmission	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for TAC1 available from Tocris Bioscience

Compound	Action	CAS number
MEN 10376	Potent, selective NK2 antagonist	[135306-85-3]
GR 159897	Non-peptide, potent NK2 antagonist	[158848-32-9]
GR 94800	Potent, selective NK2 antagonist	[141636-65-9]
GR 64349	Potent, selective NK2 agonist	[137593-52-3]
MEN 10627	Potent, selective NK2 antagonist	[157351-81-0]

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10/49 Novoseek chemical compound relationships for TAC1 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
senktide	93.08	55	7544197 (5), 7824047 (3), 9543242 (2), 8864543 (2) (see all 28)
sr48968	91.14	28	7961636 (2), 18601911 (2), 11591520 (1), 14718265 (1) (see all 21)
eledoisin	87.56	44	1708071 (3), 1712834 (2), 1719434 (2), 1707714 (1) (see all 22)
fk 224	87.16	10	8665034 (2), 8726939 (1), 9302648 (1), 9243258 (1) (see all 6)
septide	86.56	41	9786514 (3), 8985159 (3), 8786533 (2), 10214937 (2) (see all 13)
fk 888	84.64	8	7889271 (2), 9302648 (1), 7534186 (1), 8529964 (1) (see all 7)
cyclo(gln-trp-phe-gly-leu-met)	80.90	8	7544197 (1), 14985054 (1), 1964226 (1), 1713430 (1) (see all 5)
gr 73632	77.95	4	1707714 (1), 7688875 (1), 7538871 (1)
kassinin	76.93	14	11245256 (1), 7532211 (1), 8859022 (1), 8702757 (1) (see all 7)
gr 82334	74.42	2	7538871 (1), 8846430 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_003182

Sigma-Aldrich siRNA for TAC1

Sigma-Aldrich shRNA Panels and shRNA for TAC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003182 NM_013996 NM_013997 NM_013998

REFSEQ mRNAs for TAC1 gene (4 alternative transcripts):

NM_003182.2 NM_013996.2 NM_013997.2 NM_013998.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003182 NM_013996 NM_013997 NM_013998

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_003182
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_003182
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_003182

Additional cDNA sequence:

AF050655.1 AF050656.1 AF050657.1 AF050658.1 AK222957.1 BC018047.1 CR407602.1 CR541730.1

M68906.1 M68907.1 U37529.1 X54469.1

4 DOTS entries:

DT.110616 DT.86746127 DT.95163775 DT.121056930

24/43 AceView cDNA sequences (see all 43 ):

CD676459 AF050656 AU105584 AF050658 M68907 AF050655 AF050657 CR407602

AA814651 CR541730 AU099398 BQ446483 BI669433 BI669514 U37529 NM_013998

BC018047 BM712701 M68906 BG714365 X54469 BI552074 NM_003182 NM_013997

highest scoring ESTs for TAC1:

U37529 AA446659 AA805229 AI277203 AI915903 AW340043 BC018047 BG708147 BG708227 BG714365

Unigene Cluster for TAC1:

Tachykinin, precursor 1

Hs.2563 [show with all ESTs]

Unigene Representative Sequence: NM_003182

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000346867 ENST00000350485 ENST00000319273

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TAC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAC1

¹ / ² / ³

3 probe-sets matching TAC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36254_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U37529	1.00	1.00	1.00	1
206552_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003182	0.60	1.00	0.82	1
206552_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TAC1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTGTGACT

SOURCE GeneReport for Unigene cluster: Hs.2563
Expression variation in blood from EXPOLDB for TAC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAC1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TAC1¹	--	tachykinin, precursor 1	96.12(n) 99.22(a)	475239 XM_845342.1 XP_850435.1
chimpanzee (Pan troglodytes)	TAC1¹	--	tachykinin, precursor 1	99.48(n) 98.45(a)	747650 XM_001171112.1 XP_001171112.1
cow (Bos taurus)	TAC1¹	--	tachykinin, precursor 1	93.28(n) 91.47(a)	281512 NM_174193.1 NP_776618.1
rat (Rattus norvegicus)	Tac1¹	--	tachykinin 1	92.76(n) 96.9(a)	24806 NM_012666.1 NP_036798.1
mouse (Mus musculus)	Tac1^{1, 5}	6 (5.00 cM)⁵	tachykinin 1^{1, 5}	93.54(n)¹ 95.35(a)¹	21333¹ NM_009311.2¹ NP_033337.1¹ AK015286⁵ AK019709⁵ (see all 11)

About this table Species with no ortholog for TAC1

ENSEMBL Gene Tree for TAC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/46 NCBI SNPs in TAC1 are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2051794^1,2	C,F,H	97197793(-)	`gcattC/Aaaata`	4	--	ng5¹		7	EU EA WA NA	562
	rs12534885^1,2	C,F,H	97207432(+)	`TGTCAA/GTGATA`	4	--	ut3¹		8	EU EA WA	828
	rs12532490^1,2	C,F,H	97207327(+)	`ATGTAT/CTGTAA`	4	--	ut3¹ ese³		4	EU EA WA	380
	rs7793277^1,2	F,H	97197521(+)	`cctgcC/Gatgtg`	4	--	ng5¹		4	EU EA WA	408
--	rs17169049^1,2	F	97198557(+)	`GTCCTG/TTTCAA`	4	--	ng5¹		2	MN EA	376
	rs4602814^1,2	A,C,F,H	97205911(+)	`GATAGC/TTGGGT`	4	--	int¹		8	EU EA WA NA	616
	rs1397202^1,2	A,C,F,H	97206943(+)	`TTCCAA/GTCAGA`	4	--	int¹		4	EU EA WA	420
	rs1229434^1,2	A,C,F,H	97203778(-)	`TGGTAA/GTATTA`	4	--	int¹		16	MN NA EU EA WA	1516
	rs2072100^1,2	A,C,F,H	97199720(-)	`GGACTG/AAAGTC`	4	--	int¹		12	EA NA EU WA	2390
	rs4526299^1,2	C,F,H	97205565(+)	`TCATAC/TACTCA`	4	--	int¹		4	EU EA WA	402

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HapMap Linkage Disequilibrium images for TAC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 162320

10/59 Novoseek disease relationships for TAC1 gene (see all 59 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	53.44	41	9038887 (1), 16290928 (1), 17170385 (1), 2390021 (1) (see all 33)
asthma	53.26	65	14749007 (6), 18507649 (5), 15707850 (4), 11991878 (3) (see all 30)
astrocytoma	38.51	4	7875535 (1), 10415087 (1), 7521949 (1), 10753681 (1)
migraine	35.42	12	8536297 (2), 16472331 (1), 9399010 (1), 17222167 (1) (see all 6)
motility disorder	34.80	1	14670823 (1)
serotonin syndrome	27.11	3	9637018 (2)
bronchitis chronic	26.22	1	12794061 (1)
carcinoid	21.51	3	9296223 (1), 14713258 (1), 16556667 (1)
allergic rhinitis	12.12	1	10547475 (1)
colitis ulcerative	10.20	3	16033908 (1), 11916195 (1)

About this table

Genetic Association Database: TAC1
Human Genome Epidemiology Navigator: TAC1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/703 PubMed articles for TAC1 gene (see all 703 ):

Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. (PubMed id 1708336)^{2, 3, 4} Chiwakata C....Ivell R. (1991)
Three-dimensional structure of neuropeptide K bound to dodecylphosphocholine micelles. (PubMed id 16503654)^{1, 3, 4} Dike A. and Cowsik S.M. (2006)
Characterization of the C-terminal flanking peptide of human beta- preprotachykinin. (PubMed id 2284201)^{1, 3, 4} McGregor G.P. and Conlon J.M. (1990)
Haplotype analysis of the preprotachykinin-1 (TAC1) gene in multiple sclerosis. (PubMed id 15729363)^{3, 6} Cunningham S....Vandenbroeck K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. (PubMed id 9846828)^{3, 4} Lai J.P....Ho W.Z. (1998)
Isolation and characterization of neurokinin A, neurokinin A(3-10) and neurokinin A(4-10) from a neutral water extract of a metastatic ileal carcinoid tumour. (PubMed id 3038549)^{3, 4} Theodorsson-Norheim E.... Jacobsson G. (1987)
cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A. (PubMed id 3770210)^{3, 4} Harmar A.J.... Fink G. (1986)
[Change of neurokinin A plasma level in asthmatic children] (PubMed id 14749007)^{1, 3} Shang Y.X....Wei K.L. (2003)
Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity. (PubMed id 18507649)^{1, 3} Mostafa G.A....Ahmed S.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6863	HGNC: 11517	AceView: TAC1	Ensembl:ENSG00000006128	euGenes: HUgn6863
ECgene: TAC1	H-InvDB: TAC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Neurokinin_1

Licensable Technologies for TAC1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAC1		Antibodies for TAC1
	Explore super-pooled esiRNAs		Proteins for TAC1
	Lentivirus-delivered shRNAs for TAC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAC1)
	Antibodies (TAC1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Substance P, Neurokinin A)
	Antibodies (Substance P, Neurokinin A)

Search OriGene for TAC1

Tocris compounds for TAC1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAC1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TAC1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TAC1

Summaries
for TAC1

Genomic Location
for TAC1

Proteins
for TAC1

Protein Domains/
Families
for TAC1

Gene Function
for TAC1

Pathways & Interactions
for TAC1

Drugs & Compounds
for TAC1

Transcripts
for TAC1

Expression
for TAC1

Orthologs
for TAC1

Paralogs
for TAC1

SNPs/Variants
for TAC1

Disorders & Mutations
for TAC1

Medical News
for TAC1

Publications
for TAC1

Search for TAC1

Genome Databases showing TAC1

Other Databases showing TAC1

Specialized Databases showing TAC1

Licensable Technologies
for TAC1

Services
for TAC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAC1 (Gene Symbol)
Hs.2563
NK2
NKA
NKNA
NPK
PPT
TAC2
neurokinin 1
neurokinin 2
neurokinin A
neurokinin alpha
neuromedin L
neuropeptide K
neuropeptide gamma
substance K
substance P
tachykinin 1
tachykinin 2
tachykinin, precursor 1
tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)

TAC1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TAC1

Summariesfor TAC1

Genomic Locationfor TAC1

Proteinsfor TAC1

Protein Domains/Familiesfor TAC1

Gene Functionfor TAC1

Pathways & Interactionsfor TAC1

Drugs & Compoundsfor TAC1

Transcriptsfor TAC1

Expression for TAC1

Orthologsfor TAC1

Paralogsfor TAC1

SNPs/Variantsfor TAC1

Disorders & Mutationsfor TAC1

Medical Newsfor TAC1

Publicationsfor TAC1

Search for TAC1

Genome Databases showing TAC1

Other Databases showing TAC1

Specialized Databases showing TAC1

Licensable Technologiesfor TAC1

Servicesfor TAC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAC1

Summaries
for TAC1

Genomic Location
for TAC1

Proteins
for TAC1

Protein Domains/
Families
for TAC1

Gene Function
for TAC1

Pathways & Interactions
for TAC1

Drugs & Compounds
for TAC1

Transcripts
for TAC1

Expression
for TAC1

Orthologs
for TAC1

Paralogs
for TAC1

SNPs/Variants
for TAC1

Disorders & Mutations
for TAC1

Medical News
for TAC1

Publications
for TAC1

Licensable Technologies
for TAC1

Services
for TAC1