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TAB3 Gene

protein-coding   GIFtS: 59
GCID: GC0XM030845

TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3

(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 31 2     TGF-Beta-Activated Kinase 1-Binding Protein 32 3
MAP3K7IP31 2 3     TAK1 Binding Protein 31
Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 31 2     NAP12
TAB-32 3     NFkB Activating Protein 12
NF-Kappa-B-Activating Protein 12 3     TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 32
TAK1-Binding Protein 32 3     Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 33

External Ids:    HGNC: 306811   Entrez Gene: 2573972   Ensembl: ENSG000001576257   OMIM: 3004805   UniProtKB: Q8N5C83   

Export aliases for TAB3 gene to outside databases

Previous GC identifers: GC0XM030209 GC0XM030608 GC0XM028586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAB3 Gene:
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the
similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase
MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1.
Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB
transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants
have been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAB3 Gene:
TAB3 (TGF-beta activated kinase 1/MAP3K7 binding protein 3) is a protein-coding gene. Diseases associated with TAB3 include gonadal dysgenesis, and glaucoma. An important paralog of this gene is TAB2.

UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1
and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may
be an oncogenic factor

Gene Wiki entry for TAB3 (MAP3K7IP3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TAB3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAB3 promoter sequence
   Search Chromatin IP Primers for TAB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.2   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.2

TAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAB3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM030845:  view genomic region     (about GC identifiers)

Start:
30,845,559 bp from pter      End:
30,993,201 bp from pter
Size:
147,643 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8 (See protein sequence)
Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3  
Size: 712 amino acids; 78683 Da
Subunit: Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex
(TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join
this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts
with RBCK1. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5
Secondary accessions: A6NDD9 Q6VQR0
Alternative splicing: 2 isoforms:  Q8N5C8-1   Q8N5C8-2   

Explore the universe of human proteins at neXtProt for TAB3: NX_Q8N5C8

Explore proteomics data for TAB3 at MOPED

Post-translational modifications: 

  • Ubiquitinated; following IL1 stimulation or TRAF6 overexpression1
  • Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_690000.2  
    ENSEMBL proteins: 
     ENSP00000368215   ENSP00000433193   ENSP00000368210   ENSP00000368212   ENSP00000288422  
     ENSP00000368214  
    Reactome Protein details: Q8N5C8

    TAB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAB3
    GenScript Custom Purified and Recombinant Proteins Services for TAB3
    Novus Biologicals TAB3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TAB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TAB3
    OriGene Custom Antibody Services for TAB3
    Novus Biologicals TAB3 Antibodies
    Search for Antibodies for TAB3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TAB3
    LSBio Antibodies in human, mouse, rat for TAB3

    TAB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAB3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001876 Znf_RanBP2
     IPR003892 CUE

    Graphical View of Domain Structure for InterPro Entry Q8N5C8

    ProtoNet protein and cluster: Q8N5C8

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB003892 Ubiquitin system component Cue


    UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
    Domain: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins (By
    similarity)
    Similarity: Contains 1 CUE domain
    Similarity: Contains 1 RanBP2-type zinc finger


    TAB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAB3_HUMAN, Q8N5C8
    Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1
    and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may
    be an oncogenic factor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17158449
    GO:0008270zinc ion binding IEA--
         
    TAB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAB3:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tab3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  normal 

    TAB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tab3tm1Aki for TAB3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAB3:
    hsa-mir-195-5p (MIRT007170), hsa-mir-23b-3p (MIRT007039)

    Block miRNA regulation of human, mouse, rat TAB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAB3 (see all 113):
    hsa-miR-549 hsa-miR-520f hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-199a-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidTAB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAB3
    Predesigned siRNA for gene silencing in human, mouse, rat TAB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAB3

    Clone
    Products:
         
    OriGene clones in human, mouse for TAB3 (see all 7)
    OriGene ORF clones in mouse, rat for TAB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAB3 (NM_152787)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    plasma membrane4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    TAB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAB3 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3MAPK targets/ Nuclear events mediated by MAP kinases
    MAP kinase activation in TLR cascade0.61
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK10.00
    activated TAK1 mediates p38 MAPK activation0.00
    4IRAK2 mediated activation of TAK1 complex
    IRAK2 mediated activation of TAK1 complex
    IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation0.00
    5PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TAB3
        NOD-like Receptor Signaling Pathways


    1 BioSystems Pathway for TAB3
        TNF-alpha/NF-kB Signaling Pathway

    Selected Reactome Pathways for TAB3 (see all 9)
        Interleukin-1 signaling
    activated TAK1 mediates p38 MAPK activation
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
    FCERI mediated NF-kB activation


    3 Kegg Pathways  (Kegg details for TAB3):
        NF-kappa B signaling pathway
    NOD-like receptor signaling pathway
    TNF signaling pathway


    TAB3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAB3
    Interactions:

        Search GeneGlobe Interaction Network for TAB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAB3 (Q8N5C81, 2, 3 ENSP000002884224) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BECN1Q144571, 2, ENSP000003552314EBI-359964,EBI-949378 MINT-8304392 MINT-8303905 MINT-8304450 MINT-8327871 MINT-8304506 MINT-8304232 MINT-8303946 MINT-8304218 MINT-8304320 STRING: ENSP00000355231
    MAP3K7O433181, 2, 3, ENSP000003583354EBI-359964,EBI-358684 MINT-49237 MINT-8303905 MINT-8303937 MINT-48036 I2D: score=4 STRING: ENSP00000358335
    MAP3K7CLP570772, 3, ENSP000003432124MINT-67362 I2D: score=4 STRING: ENSP00000343212
    TAB1Q157503, ENSP000002161604I2D: score=3 STRING: ENSP00000216160
    RBCK1Q9BYM83, ENSP000003486324I2D: score=1 STRING: ENSP00000348632
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0007249I-kappaB kinase/NF-kappaB signaling TAS--

    TAB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAB3

    1 Novoseek inferred chemical compound relationship for TAB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 97.5 25 14670075 (6), 14633987 (5), 19927120 (3), 19955178 (3) (see all 7)



    TAB3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAB3 gene (2 alternative transcripts): 
    NM_152787.3  NM_198312.1  

    Unigene Cluster for TAB3:

    TGF-beta activated kinase 1/MAP3K7 binding protein 3
    Hs.188256  [show with all ESTs]
    Unigene Representative Sequence: AL832071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378933(uc004dcj.3 uc004dck.3 uc010ngl.3) ENST00000467136
    ENST00000378928 ENST00000378930 ENST00000288422 ENST00000378932
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAB3 (see all 113):
    hsa-miR-549 hsa-miR-520f hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-199a-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidTAB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAB3
    Predesigned siRNA for gene silencing in human, mouse, rat TAB3
    Clone
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    OriGene clones in human, mouse for TAB3 (see all 7)
    OriGene ORF clones in mouse, rat for TAB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAB3 (NM_152787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TAB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAB3
      QuantiTect SYBR Green Assays in human, mouse, rat TAB3
      QuantiFast Probe-based Assays in human, mouse, rat TAB3

    Additional mRNA sequence: 

    AK096786.1 AK297274.1 AL832071.1 AY371491.1 AY437560.1 BC032526.1 

    6 DOTS entries:

    DT.97806119  DT.97799162  DT.75130520  DT.101981398  DT.121304684  DT.86840948 

    Selected AceView cDNA sequences (see all 71):

    CB163503 BU688642 AI470410 BP375414 AY371491 BQ025617 AI419265 C00236 
    AI421406 AW518138 BX456736 BM450259 BG493286 AW148358 AI733853 AI493387 
    BF593914 AI096841 BM465254 AL832071 AW236264 AY437560 BU861012 CA489030 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TAB3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for TAB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCGTACCT
    TAB3 Expression
    About this image


    TAB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    TAB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.188256

    UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
    Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major
    transcript while isoform 2 is a minor transcript

        Custom PCR Arrays for TAB3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TAB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAB3
    QuantiTect SYBR Green Assays in human, mouse, rat TAB3
    QuantiFast Probe-based Assays in human, mouse, rat TAB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tab31 , 5 TGF-beta activated kinase 1/MAP3K7 binding protein more1, 5 92.51(n)1
    95.22(a)1
      X (39.32 cM)5
    667241  NM_025729.41  NP_080005.21 
     855740225 
    chicken
    (Gallus gallus)
    Aves TAB31 TGF-beta activated kinase 1/MAP3K7 binding protein more 83.78(n)
    87.5(a)
      418588  XM_416787.4  XP_416787.3 
    lizard
    (Anolis carolinensis)
    Reptilia TAB36
    TGF-beta activated kinase 1/MAP3K7 binding protein...
    82(a)
    1 ↔ 1
    3(129002267-129043991)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF549911.12   -- 77.34(n)    AF549911.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.112502 Transcribed sequence with weak similarity to protein more 76.19(n)    57096212 


    ENSEMBL Gene Tree for TAB3 (if available)
    TreeFam Gene Tree for TAB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAB3 gene
    TAB22  
    2 SIMAP similar genes for TAB3 using alignment to 3 protein entries:     TAB3_HUMAN (see all proteins):
    DKFZp313L0918    TAB2

    TAB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAB3
    PGOHUM00000261825


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAB3 (see all 826)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813063611,2
    --30759672(+) GATTAA/CAAGCA 1 -- ds50010--------
    rs1866533731,2
    --30759852(+) TTTTTA/TAAAAA 1 -- ds50010--------
    rs1917162631,2
    --30760017(+) ATTACA/GTGTTC 1 -- ds50010--------
    rs1834806361,2
    --30760536(+) AAATAA/GTACAG 1 -- ut310--------
    rs1872041091,2
    --30760782(+) ATTCAA/GTTTTT 1 -- ut310--------
    rs1912179991,2
    --30761079(+) TTTCTC/TCCAGG 1 -- ut310--------
    rs1476530981,2
    --30761328(+) GCAAAC/TGTGCT 1 -- ut310--------
    rs1822652641,2
    --30761329(+) CAAACG/TTGCTT 1 -- ut310--------
    rs169891941,2
    C,F,H--30761489(+) CAGGCA/GTCATC 1 -- ut31 ese315Minor allele frequency- G:0.91NA NS EA 1946
    rs413052151,2
    C--30761515(+) CACTTA/CCATGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TAB3 (30845559 - 30993201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1282137CNV Deletion17803354

    Locus Specific Mutation Databases (LSDB): TAB3

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300480    OMIM disorders: --

    5 diseases for TAB3:    
    About MalaCards
    gonadal dysgenesis    glaucoma    amyotrophic lateral sclerosis    lateral sclerosis
    breast cancer


    TAB3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TAB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 44.7 3 14766965 (2), 18021073 (1)
    tumors 13.3 2 14766965 (2)

    Genetic Association Database (GAD): TAB3

    Export disorders for TAB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAB3 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with TAB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAB3, a new binding partner of the protein kinase TAK1. (PubMed id 14670075)1, 2, 3, 9 Cheung P.C.... Cohen P. (Biochem. J. 2004)
    2. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1, 2, 3, 9 Ishitani T....Matsumoto K. (EMBO J. 2003)
    3. Identification of a human NF-kappaB-activating protein, TAB3. (PubMed id 14766965)1, 2, 9 Jin G.... Sherf B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. (PubMed id 18021073)1, 2, 9 Mendoza H.... Cohen P. (Biochem. J. 2008)
    5. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1- triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)1, 2, 9 Tian Y.... Shu H.B. (J. Biol. Chem. 2007)
    6. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. (PubMed id 21512573)1, 2 Pertel T.... Luban J. (Nature 2011)
    7. WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4- induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2 Gao D.... Chen D.Y. (Cell. Mol. Life Sci. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. (PubMed id 19927120)1, 9 Sato Y....Fukai S. (EMBO J. 2009)
    10. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. (PubMed id 17158449)1, 9 Besse A....Darnay B.G. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 257397 HGNC: 30681 AceView: TAB3 Ensembl:ENSG00000157625 euGenes: HUgn257397
    ECgene: TAB3 Kegg: 257397 H-InvDB: TAB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAB3 gene:
    Search GeneIP for patents involving TAB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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