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Aliases for TAB3 Gene

Aliases for TAB3 Gene

  • TGF-Beta Activated Kinase 1 And MAP3K7 Binding Protein 3 2 3 5
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 2 3
  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3 2 3
  • TGF-Beta-Activated Kinase 1-Binding Protein 3 3 4
  • NF-Kappa-B-Activating Protein 1 3 4
  • TAK1-Binding Protein 3 3 4
  • MAP3K7IP3 3 4
  • TAB-3 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 4
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 3 3
  • NFkB Activating Protein 1 3
  • TAK1 Binding Protein 3 2
  • NAP1 3

External Ids for TAB3 Gene

Previous HGNC Symbols for TAB3 Gene

  • MAP3K7IP3

Previous GeneCards Identifiers for TAB3 Gene

  • GC0XM030209
  • GC0XM030608
  • GC0XM028586

Summaries for TAB3 Gene

Entrez Gene Summary for TAB3 Gene

  • The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB3 Gene

TAB3 (TGF-Beta Activated Kinase 1 And MAP3K7 Binding Protein 3) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. An important paralog of this gene is TAB2.

UniProtKB/Swiss-Prot for TAB3 Gene

  • Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Gene Wiki entry for TAB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB3 Gene

Genomics for TAB3 Gene

Regulatory Elements for TAB3 Gene

Enhancers for TAB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG030874 1 Ensembl ENCODE 27.9 +98.9 98903 2.9 FOXA2 SAP130 CEBPG THRB RARA TEAD3 CTBP1 NR2F6 GATAD2A TFE3 TAB3 TAB3-AS2
GH0XG030886 1.1 ENCODE 22.2 +86.4 86362 3.5 PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 ZNF263 SP3 SP5 ZHX2 TAB3 TAB3-AS2
GH0XG030822 0.9 FANTOM5 ENCODE 12.6 +152.2 152192 0.8 CTCF MTA2 DPF2 TBX21 IKZF1 EED NBN RELB IKZF2 SPI1 TAB3-AS2 TAB3 GK CXorf21 LOC100418759 GC0XM030798
GH0XG030939 0.7 ENCODE 12.7 +34.3 34298 2.5 ESRRA ZNF146 NR2F1 BHLHE40 HLF MITF FOSL1 JUND ATF3 PBX2 TAB3 TAB3-AS2
GH0XG030943 0.6 ENCODE 12.8 +30.6 30565 1.5 ARID1B SMARCE1 GATA2 SMARCA4 EGR1 ZNF34 ZNF512 TAB3 TAB3-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAB3 Gene

Chromosome:
X
Start:
30,827,442 bp from pter
End:
30,975,084 bp from pter
Size:
147,643 bases
Orientation:
Minus strand

Genomic View for TAB3 Gene

Genes around TAB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB3 Gene

Proteins for TAB3 Gene

  • Protein details for TAB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5C8-TAB3_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Protein Accession:
    Q8N5C8
    Secondary Accessions:
    • A6NDD9
    • Q6VQR0

    Protein attributes for TAB3 Gene

    Size:
    712 amino acids
    Molecular mass:
    78683 Da
    Quaternary structure:
    • Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds Lys-63-linked polyubiquitin chains. Interacts with TRIM5.

    Alternative splice isoforms for TAB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB3 Gene

Post-translational modifications for TAB3 Gene

  • Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
  • Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAB3 Gene

Domains & Families for TAB3 Gene

Gene Families for TAB3 Gene

Protein Domains for TAB3 Gene

Suggested Antigen Peptide Sequences for TAB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5C8

UniProtKB/Swiss-Prot:

TAB3_HUMAN :
  • The RanBP2-type zinc finger (NZF) mediates binding to two consecutive Lys-63-linked ubiquitins.
Domain:
  • The RanBP2-type zinc finger (NZF) mediates binding to two consecutive Lys-63-linked ubiquitins.
genes like me logo Genes that share domains with TAB3: view

Function for TAB3 Gene

Molecular function for TAB3 Gene

UniProtKB/Swiss-Prot Function:
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Gene Ontology (GO) - Molecular Function for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17158449
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TAB3: view
genes like me logo Genes that share phenotypes with TAB3: view

Animal Models for TAB3 Gene

MGI Knock Outs for TAB3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB3 Gene

Localization for TAB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAB3 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
endosome 4

Gene Ontology (GO) - Cellular Components for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with TAB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB3 Gene

Pathways & Interactions for TAB3 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNF signaling (REACTOME)
3 IL-1 signaling pathway
4 Toll-Like receptor Signaling Pathways
5 CLEC7A (Dectin-1) signaling
genes like me logo Genes that share pathways with TAB3: view

SIGNOR curated interactions for TAB3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS --
GO:0007254 JNK cascade TAS --
genes like me logo Genes that share ontologies with TAB3: view

Drugs & Compounds for TAB3 Gene

(1) Drugs for TAB3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NG25 Pharma 0

(1) Additional Compounds for TAB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TAB3 Gene

Compound Action Cas Number
NG25 1315355-93-1
genes like me logo Genes that share compounds with TAB3: view

Drug Products

Transcripts for TAB3 Gene

Unigene Clusters for TAB3 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for TAB3 Gene

GeneLoc Exon Structure for
TAB3
ECgene alternative splicing isoforms for
TAB3

Expression for TAB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAB3 Gene

This gene is overexpressed in Ovary (18.8), Stomach (7.3), and Colon muscle (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAB3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAB3 Gene:

TAB3

SOURCE GeneReport for Unigene cluster for TAB3 Gene:

Hs.188256

mRNA Expression by UniProt/SwissProt for TAB3 Gene:

Q8N5C8-TAB3_HUMAN
Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.

Evidence on tissue expression from TISSUES for TAB3 Gene

  • Liver(4.3)
  • Kidney(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with TAB3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB3 Gene

Orthologs for TAB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAB3 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia TAB3 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAB3 34 35
  • 94.66 (n)
rat
(Rattus norvegicus)
Mammalia Tab3 34
  • 92.59 (n)
mouse
(Mus musculus)
Mammalia Tab3 34 16 35
  • 92.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TAB3 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB3 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAB3 34 35
  • 83.78 (n)
lizard
(Anolis carolinensis)
Reptilia TAB3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495158 34
  • 71.32 (n)
zebrafish
(Danio rerio)
Actinopterygii tab3 34 35
  • 58.96 (n)
Dr.11250 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6734 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10639 35
  • 32 (a)
OneToMany
Species where no ortholog for TAB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAB3 Gene

ENSEMBL:
Gene Tree for TAB3 (if available)
TreeFam:
Gene Tree for TAB3 (if available)

Paralogs for TAB3 Gene

Paralogs for TAB3 Gene

(2) SIMAP similar genes for TAB3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TAB3 Gene

genes like me logo Genes that share paralogs with TAB3: view

Variants for TAB3 Gene

Sequence variations from dbSNP and Humsavar for TAB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000032598 -- 30,871,328(+) TTCTT(G/T)GGGGC intron-variant
rs1000082522 -- 30,883,503(+) CATGC(A/G)CTTAA intron-variant
rs1000093633 -- 30,867,269(+) GAATA(A/T)AGACT intron-variant
rs1000129516 -- 30,843,837(+) GTCCT(A/G)CCTTC intron-variant, nc-transcript-variant
rs1000150902 -- 30,866,731(+) GGGGG(A/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAB3 Gene

Variant ID Type Subtype PubMed ID
esv1282137 CNV deletion 17803354
nsv1110077 CNV deletion 24896259

Variation tolerance for TAB3 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB3 Gene

Disorders for TAB3 Gene

Relevant External Links for TAB3

Genetic Association Database (GAD)
TAB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAB3

No disorders were found for TAB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB3 Gene

Publications for TAB3 Gene

  1. TAB3, a new binding partner of the protein kinase TAK1. (PMID: 14670075) Cheung P.C. … Cohen P. (Biochem. J. 2004) 2 3 4 22 64
  2. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PMID: 14633987) Ishitani T. … Matsumoto K. (EMBO J. 2003) 2 3 4 22 64
  3. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. (PMID: 18021073) Mendoza H. … Cohen P. (Biochem. J. 2008) 3 4 22 64
  4. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1- triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PMID: 17449468) Tian Y. … Shu H.B. (J. Biol. Chem. 2007) 3 4 22 64
  5. Identification of a human NF-kappaB-activating protein, TAB3. (PMID: 14766965) Jin G. … Sherf B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64

Products for TAB3 Gene

Sources for TAB3 Gene

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