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Aliases for TAB3 Gene

Aliases for TAB3 Gene

  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3 2 3
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 3 2 3
  • TGF-Beta-Activated Kinase 1-Binding Protein 3 3 4
  • NF-Kappa-B-Activating Protein 1 3 4
  • TAK1-Binding Protein 3 3 4
  • MAP3K7IP3 3 4
  • TAB-3 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 4
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 3 3
  • NFkB Activating Protein 1 3
  • TAK1 Binding Protein 3 2
  • NAP1 3

External Ids for TAB3 Gene

Previous HGNC Symbols for TAB3 Gene

  • MAP3K7IP3

Previous GeneCards Identifiers for TAB3 Gene

  • GC0XM030209
  • GC0XM030608
  • GC0XM028586

Summaries for TAB3 Gene

Entrez Gene Summary for TAB3 Gene

  • The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB3 Gene

TAB3 (TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 3) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Interferon Signaling. An important paralog of this gene is TAB2.

UniProtKB/Swiss-Prot for TAB3 Gene

  • Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Gene Wiki entry for TAB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB3 Gene

Genomics for TAB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAB3 Gene

Start:
30,827,442 bp from pter
End:
30,975,084 bp from pter
Size:
147,643 bases
Orientation:
Minus strand

Genomic View for TAB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB3 Gene

No data available for Regulatory Elements for TAB3 Gene

Proteins for TAB3 Gene

  • Protein details for TAB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5C8-TAB3_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Protein Accession:
    Q8N5C8
    Secondary Accessions:
    • A6NDD9
    • Q6VQR0

    Protein attributes for TAB3 Gene

    Size:
    712 amino acids
    Molecular mass:
    78683 Da
    Quaternary structure:
    • Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds Lys-63-linked polyubiquitin chains. Interacts with TRIM5.

    Alternative splice isoforms for TAB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB3 Gene

Proteomics data for TAB3 Gene at MOPED

Post-translational modifications for TAB3 Gene

  • Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment.
  • Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TAB3 (TAB3)

No data available for DME Specific Peptides for TAB3 Gene

Domains for TAB3 Gene

Protein Domains for TAB3 Gene

Suggested Antigen Peptide Sequences for TAB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5C8

UniProtKB/Swiss-Prot:

TAB3_HUMAN :
  • Q8N5C8
Domain:
  • The RanBP2-type zinc finger (NZF) mediates binding to two consecutive Lys-63-linked ubiquitins.
  • Contains 1 CUE domain.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with TAB3: view

No data available for Gene Families for TAB3 Gene

Function for TAB3 Gene

Molecular function for TAB3 Gene

UniProtKB/Swiss-Prot Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Gene Ontology (GO) - Molecular Function for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17158449
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TAB3: view
genes like me logo Genes that share phenotypes with TAB3: view

Animal Models for TAB3 Gene

MGI Knock Outs for TAB3:

Animal Model Products

CRISPR Products

miRNA for TAB3 Gene

miRTarBase miRNAs that target TAB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAB3 Gene

Localization for TAB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAB3 Gene COMPARTMENTS Subcellular localization image for TAB3 gene
Compartment Confidence
cytosol 4
endosome 4
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TAB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB3 Gene

Pathways for TAB3 Gene

genes like me logo Genes that share pathways with TAB3: view

Gene Ontology (GO) - Biological Process for TAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB3: view

Compounds for TAB3 Gene

(1) Novoseek inferred chemical compound relationships for TAB3 Gene

Compound -log(P) Hits PubMed IDs
tab-2 97.5 22
genes like me logo Genes that share compounds with TAB3: view

Transcripts for TAB3 Gene

Unigene Clusters for TAB3 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAB3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAB3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for TAB3 Gene

GeneLoc Exon Structure for
TAB3
ECgene alternative splicing isoforms for
TAB3

Expression for TAB3 Gene

mRNA expression in normal human tissues for TAB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAB3 Gene

SOURCE GeneReport for Unigene cluster for TAB3 Gene Hs.188256

mRNA Expression by UniProt/SwissProt for TAB3 Gene

Q8N5C8-TAB3_HUMAN
Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.
genes like me logo Genes that share expressions with TAB3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAB3 Gene

Orthologs for TAB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAB3 35
  • 99.77 (n)
  • 99.86 (a)
TAB3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAB3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAB3 35
  • 94.66 (n)
  • 97.61 (a)
TAB3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tab3 35
  • 92.51 (n)
  • 95.22 (a)
Tab3 16
Tab3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAB3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB3 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tab3 35
  • 92.59 (n)
  • 94.23 (a)
chicken
(Gallus gallus)
Aves TAB3 35
  • 83.78 (n)
  • 87.5 (a)
TAB3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAB3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495158 35
  • 71.32 (n)
  • 70.93 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6734 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11250 35
tab3 35
  • 58.96 (n)
  • 58.96 (a)
tab3 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10639 36
  • 32 (a)
OneToMany
Species with no ortholog for TAB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAB3 Gene

ENSEMBL:
Gene Tree for TAB3 (if available)
TreeFam:
Gene Tree for TAB3 (if available)

Paralogs for TAB3 Gene

Paralogs for TAB3 Gene

Selected SIMAP similar genes for TAB3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TAB3 Gene

genes like me logo Genes that share paralogs with TAB3: view

Variants for TAB3 Gene

Sequence variations from dbSNP and Humsavar for TAB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1482833 -- 30,840,710(+) TGTGA(G/T)GCCCG intron-variant
rs1905204 -- 30,836,408(+) TAACA(G/T)CAAGC intron-variant, nc-transcript-variant
rs2306530 -- 30,830,511(-) TTGGA(A/T)ATCTT utr-variant-3-prime
rs2867974 -- 30,845,524(+) ttgaa(A/G)cacaa intron-variant, nc-transcript-variant
rs3816757 -- 30,830,839(-) ACAAA(C/G)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TAB3 Gene

Variant ID Type Subtype PubMed ID
esv1282137 CNV Deletion 17803354

Relevant External Links for TAB3 Gene

HapMap Linkage Disequilibrium report
TAB3
Locus Specific Mutation Databases (LSDB)
TAB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB3 Gene

Disorders for TAB3 Gene

(2) Novoseek inferred disease relationships for TAB3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 44.7 3
tumors 13.3 2

Relevant External Links for TAB3

Genetic Association Database (GAD)
TAB3
genes like me logo Genes that share disorders with TAB3: view

No data available for UniProtKB/Swiss-Prot for TAB3 Gene

Publications for TAB3 Gene

  1. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PMID: 14633987) Ishitani T. … Matsumoto K. (EMBO J. 2003) 2 3 4 23
  2. TAB3, a new binding partner of the protein kinase TAK1. (PMID: 14670075) Cheung P.C. … Cohen P. (Biochem. J. 2004) 2 3 4 23
  3. Identification of a human NF-kappaB-activating protein, TAB3. (PMID: 14766965) Jin G. … Sherf B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1- triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PMID: 17449468) Tian Y. … Shu H.B. (J. Biol. Chem. 2007) 3 4 23
  5. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. (PMID: 18021073) Mendoza H. … Cohen P. (Biochem. J. 2008) 3 4 23

Products for TAB3 Gene

Sources for TAB3 Gene

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