TAB3 Gene
protein-coding GIFtS: 57
GCID: GC0XM030845
|
|
TGF-beta activated kinase 1/MAP3K7 binding protein 3(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP3)
| |
Aliases
for TAB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 31 2 | | TGF-Beta-Activated Kinase 1-Binding Protein 32 3 | | MAP3K7IP31 2 3 | | NAP12 | | Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 31 2 | | NFkB Activating Protein 12 | | TAB-32 3 | | TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 32 | | NF-Kappa-B-Activating Protein 12 3 | | Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 33 | | TAK1-Binding Protein 32 3 | | |
Export aliases for TAB3 gene to outside databasesPrevious GC identifers: GC0XM030209 GC0XM030608 GC0XM028586 |
Summaries
for TAB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAB3:
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similarand functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 andeither TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. SubsequentMAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, buttheir biological validity has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 andTNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be anoncogenic factor
Gene Wiki entry for TAB3 (MAP3K7IP3)
|
Genomic Views
for TAB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TAB3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.2 Ensembl cytogenetic band: Xp21.2 HGNC cytogenetic band: Xp21.2TAB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM030845: view genomic region
(about GC identifiers)
Start:
|
30,845,559 bp from pter |
End:
|
30,993,201 bp from pter |
Size:
|
147,643 bases |
Orientation:
|
minus strand |
|
Proteins
for TAB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8 (See
protein sequence)Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 Size: 712 amino acids; 78683 Da
Subunit: Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3)appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may actin a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1. Binds'Lys-63'-linked polyubiquitin chains. Interacts with TRIM5
Secondary accessions: A6NDD9 Q6VQR0Alternative splicing: 2 isoforms: Q8N5C8-1 Q8N5C8-2 Explore the universe of human proteins at neXtProt for TAB3: NX_Q8N5C8
Post-translational modifications:
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression1
Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5C8
TAB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_690000.2
ENSEMBL proteins: ENSP00000368215 ENSP00000433193 ENSP00000368210 ENSP00000368212 ENSP00000288422 ENSP00000368214 Reactome Protein details: Q8N5C8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TAB3 for ontologies About GeneDecksing
TAB3 Antibody Products:
Assay Products for TAB3: |
Protein
Domains /
Families
for TAB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N5C8ProtoNet protein and cluster: Q8N5C8 2 Blocks protein families: IPB001876 Zn-finger IPB003892 Ubiquitin system component Cue
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8Domain: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins (Bysimilarity)Similarity: Contains 1 CUE domainSimilarity: Contains 1 RanBP2-type zinc finger |
Function
for TAB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 andTNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be anoncogenic factor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAB3 (NM_152787) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TAB3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TAB3:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tab3):
TAB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TAB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | | | 3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 4 | Signal Transduction | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TAB3
5/34 
Reactome Pathways for TAB3 (see all 34)
1 
Kegg Pathway (Kegg details for TAB3):
TAB3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/36 Interacting proteins for TAB3 (Q8N5C81, 2, 3 ENSP000002884224) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000187 | activation of MAPK activity |
TAS | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0007249 | I-kappaB kinase/NF-kappaB cascade |
TAS | -- |
TAB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TAB3 for compounds About GeneDecksing
 Browse Tocris compounds for TAB3
1 Novoseek chemical compound relationship for TAB3 gene About this table
Search CenterWatch for drugs/clinical trials and news about TAB3
|
Transcripts
for TAB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAB3 gene (2 alternative transcripts): NM_152787.3 NM_198312.1 Unigene Cluster for TAB3: TGF-beta activated kinase 1/MAP3K7 binding protein 3 Hs.188256 [show with all ESTs]Unigene Representative Sequence: AL8320716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378933(uc004dcj.3 uc004dck.3 uc010ngl.3) ENST00000467136
ENST00000378928 ENST00000378930 ENST00000288422 ENST00000378932
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAB3 (NM_152787) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB3 |
Additional cDNA sequence: AK096786.1 AK297274.1 AL832071.1 AY371491.1 AY437560.1 BC032526.1 6 DOTS entries: DT.97806119 DT.97799162 DT.75130520 DT.101981398 DT.121304684 DT.86840948 24/71 AceView cDNA sequences (see all 71): AI419265 AY371491 AI421406 BG493286 AI733853 C00236 BX456736 AW518138 BP375414 AW148358 BQ025617 AI470410 CB163503 BU688642 BM450259 AY437560 BF939787 BM465254 BG166706 AI359882 BI092372 AW236264 AW614824 BE858609
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TAB3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for TAB3
|
Expression
for TAB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCGTACCT
About this image
See TAB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAB3
SOURCE GeneReport for Unigene cluster: Hs.188256
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a majortranscript while isoform 2 is a minor transcript
SABiosciences Custom PCR Arrays for TAB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB3 |
Orthologs
for TAB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAB3 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tab31 , 5 |
TGF-beta activated kinase 1/MAP3K7 binding protein more1, 5 |
92.51(n)1
95.22(a)1 |
|
X (39.32 cM)5
667241 NM_025729.41 NP_080005.21
855740225 |
chicken
(Gallus gallus) |
Aves |
TAB31 |
TGF-beta activated kinase 1/MAP3K7 binding protein more |
83.88(n)
87.65(a) |
|
418588 XM_416787.3 XP_416787.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TAB36 |
-- |
80(a) |
1 ↔ 1 |
3(129014162-129042083) |
African clawed frog
(Xenopus laevis) |
Amphibia |
AF549911.12 |
-- |
77.34(n) |
|
AF549911.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.112502 |
Transcribed sequence with weak similarity to protein more |
76.19(n) |
|
57096212 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tab26 |
TAK1-associated binding protein 2 |
15(a) |
1 → many |
2R(15180034-15192013) |
ENSEMBL Gene Tree for TAB3 (if available)
TreeFam Gene Tree for TAB3 (if available) |
Paralogs
for TAB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAB3 gene
- TAB22
2 SIMAP similar genes for TAB3 using alignment to 3 protein entries: TAB3_HUMAN (see all proteins):DKFZp313L0918 TAB2
TAB3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TAB3
PGOHUM00000261825
|
Genomic Variants
for TAB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAB3 (30845559 - 30993201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAB3
1 CNV: 3265
Locus Specific Mutation Databases (LSDB): TAB3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB3 |
|
Disorders
/ Diseases
for TAB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAB3 for disorders About GeneDecksing
OMIM gene information: 300480
OMIM disorders: --
2  diseases for TAB3: About MalaCardsgonadal dysgenesis breast cancer
2 Novoseek disease relationships for TAB3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
44.7 |
3 |
14766965 (2), 18021073 (1) |
| tumors |
13.3 |
2 |
14766965 (2) |
Export disorders for TAB3 gene to outside databases
|
Publications
for TAB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAB3 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TAB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAB3, a new binding partner of the protein kinase TAK1. (PubMed id 14670075)1, 2, 3, 9 Cheung P.C.... Cohen P. (2004)
- Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1, 2, 3, 9 Ishitani T....Matsumoto K. (2003)
- Identification of a human NF-kappaB-activating protein, TAB3. (PubMed id 14766965)1, 2, 9 Jin G.... Sherf B. (2004)
- Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. (PubMed id 18021073)1, 2, 9 Mendoza H....Cohen P. (2008)
- RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)1, 2, 9 Tian Y....Shu H.B. (2007)
- TRIM5 is an innate immune sensor for the retrovirus c apsid lattice. (PubMed id 21512573)1, 2 Pertel T....Luban J. (2011)
- WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2 Gao D....Chen D.Y. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural basis for specific recognition of Lys 63-l inked polyubiquitin chains by NZF domains of TAB2 and TAB3. (PubMed id 19927120)1, 9 Sato Y....Fukai S. (2009)
- TAK1-dependent signaling requires functional interaction with TAB2/TAB3. (PubMed id 17158449)1, 9 Besse A....Darnay B.G. (2007)
|
External Searches for TAB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAB3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAB3 gene:
Search GeneIP for patents involving TAB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TAB3 | | OriGene shRNA RFP for TAB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAB3 | | OriGene 3'-UTR Clone for TAB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAB3 | | OriGene Custom Protein Services for TAB3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB3 |
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| | | | Search Tocris compounds for TAB3 |
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 | | | TAB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB3 |
|  |  |  | | | | ThermoFisher Antibodies for TAB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB3 |
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