TAB2 Gene
protein-coding GIFtS: 63
GCID: GC06P149541
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TGF-beta activated kinase 1/MAP3K7 binding protein 2(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP2)
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Aliases
for TAB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 21 2 | | TAK1-Binding Protein 22 3 | | MAP3K7IP21 2 3 5 | | TGF-Beta-Activated Kinase 1-Binding Protein 22 3 | | KIAA07331 3 5 | | CHTD22 5 | | Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 22 3 | | Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 21 | | TAB-22 3 | | TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 22 |
Export aliases for TAB2 gene to outside databasesPrevious GC identifers: GC06P149639 GC06P147206 GC06P149540 |
Summaries
for TAB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAB2:
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activationof nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus servesas an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transductioninduced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which mayregulate the development and function of osteoclasts. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The bindingof 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heartdevelopment
Gene Wiki entry for TAB2 (MAP3K7IP2)
|
Genomic Views
for TAB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TAB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1TAB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P149541: view genomic region
(about GC identifiers)
Start:
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149,539,777 bp from pter |
End:
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149,732,749 bp from pter |
Size:
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192,973 bases |
Orientation:
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plus strand |
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Proteins
for TAB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8 (See
protein sequence)Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 Size: 693 amino acids; 76494 Da
Subunit: Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (viaC-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts withRBCK1. Interacts with TRIM5
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation,translocation occurs from the membrane to cytosol
Sequence caution: Sequence=BAA34453.2; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for TAB2:2DAE (3D)
2WWZ (3D)
2WX0 (3D)
2WX1 (3D)
Secondary accessions: B2RCC4 E1P5A0 O94838 Q6I9W8 Q76N06 Q9UFP7Alternative splicing: 2 isoforms: Q9NYJ8-1 Q9NYJ8-2 Explore the universe of human proteins at neXtProt for TAB2: NX_Q9NYJ8
Post-translational modifications:
Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomaldegradation1
Phosphorylated (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYJ8
TAB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055908.1
ENSEMBL proteins: ENSP00000356426 ENSP00000432709 ENSP00000443206 ENSP00000445752 ENSP00000286332 ENSP00000376106 Reactome Protein details: Q9NYJ8
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TAB2 for ontologies About GeneDecksing
TAB2 Antibody Products:
Assay Products for TAB2: |
Protein
Domains /
Families
for TAB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAB2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYJ8ProtoNet protein and cluster: Q9NYJ8 2 Blocks protein families: IPB001876 Zn-finger IPB003892 Ubiquitin system component Cue
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8Domain: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins (Bysimilarity)Similarity: Contains 1 CUE domainSimilarity: Contains 1 RanBP2-type zinc finger |
Function
for TAB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The bindingof 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heartdevelopment
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAB2 (NM_015093) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TAB2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TAB2: Tab2tm1Brs Tab2tm1Aki
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Tab2):
TAB2 for phenotypes About GeneDecksing
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Pathways & Interactions
for TAB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | | | 3 | Immune response_Bacterial infections in normal airways | | | 4 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for TAB2
1  R&D Systems Pathway for TAB2
3 
Cell Signaling Technology (CST) Pathways for TAB2
5/7  GeneGo (Thomson Reuters) Pathways for TAB2 (see all 7)
5/9  BioSystems Pathways for TAB2 (see all 9)
5/40 
Reactome Pathways for TAB2 (see all 40)
5/7 
Kegg Pathways (Kegg details for TAB2) (see all 7):
TAB2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/131 Interacting proteins for TAB2 (Q9NYJ81, 2, 3 ENSP000002863324) via UniProtKB, MINT, STRING, and/or I2D (see all 131)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000187 | activation of MAPK activity |
TAS | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0007249 | I-kappaB kinase/NF-kappaB cascade |
TAS | -- |
TAB2 for ontologies About GeneDecksing
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Drugs & Compounds
for TAB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TAB2 for compounds About GeneDecksing
 Browse Tocris compounds for TAB2
2 Novoseek chemical compound relationships for TAB2 gene About this table
Search CenterWatch for drugs/clinical trials and news about TAB2
|
Transcripts
for TAB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAB2 gene (2 alternative transcripts): NM_015093.4 NM_145342.1 Unigene Cluster for TAB2: TGF-beta activated kinase 1/MAP3K7 binding protein 2 Hs.269775 [show with all ESTs]Unigene Representative Sequence: NM_0150938 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461481 ENST00000367456 ENST00000470466 ENST00000484505 ENST00000536230
ENST00000538427(uc011eec.2 uc003qmj.3 uc010kia.1 uc010kib.2 uc003qmk.4)
ENST00000286332 ENST00000392282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAB2 (NM_015093) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB2 |
Additional cDNA sequence: AB018276.2 AF241230.1 AK025538.1 AK295750.1 AK307650.1 AK315038.1 AL050180.1 BC035910.2 CR457387.1 9 DOTS entries: DT.100027704 DT.447352 DT.100678319 DT.100757599 DT.100788776 DT.91814258 DT.95276579 DT.95276605 DT.97847616 24/313 AceView cDNA sequences (see all 313): F11185 NM_145342 AI628078 AI379462 BM694003 CD722379 CA418565 BM449932 BM562480 AL117407 BM755346 BM841337 BX644218 AW273450 AI791982 AA988081 AA583691 AA694557 AL050180 CB154677 BM724889 AA772606 CA412946 BM904968
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TAB2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TAB2
|
Expression
for TAB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATTTATA
About this image
See TAB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAB2
SOURCE GeneReport for Unigene cluster: Hs.269775
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8Tissue specificity: Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of theconotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves
SABiosciences Expression via Pathway-Focused PCR Arrays including TAB2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB2 |
Orthologs
for TAB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAB2 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TAB21 |
TGF-beta activated kinase 1/MAP3K7 binding protein more |
85.4(n)
88.01(a) |
|
421622 XM_419660.2 XP_419660.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TAB26 |
-- |
86(a) |
1 ↔ 1 |
GL343259.1(137643-157592) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.172532 |
Xenopus laevis transcribed sequences |
86.59(n) |
|
48055137 |
zebrafish
(Danio rerio) |
Actinopterygii |
tab26 |
TGF-beta activated kinase 1/MAP3K7 binding protein... |
57(a) |
1 ↔ 1 |
20(1352940-1373480) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tab26 |
TAK1-associated binding protein 2 |
12(a) |
1 → many |
2R(15180034-15192013) |
ENSEMBL Gene Tree for TAB2 (if available)
TreeFam Gene Tree for TAB2 (if available) |
Paralogs
for TAB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAB2 gene
- TAB32
2 SIMAP similar genes for TAB2 using alignment to 2 protein entries: TAB2_HUMAN (see all proteins):TAB3 DKFZp313L0918
TAB2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TAB2
PGOHUM00000238807 PGOHUM00000245310
|
Genomic Variants
for TAB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAB2 (149539777 - 149732749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TAB2
4 Indels: 94092 94091 81635 94090
Human Gene Mutation Database (HGMD): TAB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB2 |
|
Disorders
/ Diseases
for TAB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAB2 for disorders About GeneDecksing
OMIM gene information: 605101
OMIM disorders: 612863
UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8
Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:614980]. It is adisease characterized by congenital developmental abnormalities involving structures of the heart. Clinical featuresinclude left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrialfibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been foundin a family with congenital heart disease. Translocation t(2;6)(q21;q25)
19  diseases for TAB2: About MalaCardscongenital heart disease, nonsyndromic, 2 hypohidrotic ectodermal dysplasia ectodermal dysplasia chronic lymphocytic leukemia
lymphocytic leukemia kawasaki disease graves' disease embryonal carcinoma
rheumatoid arthritis toxoplasmosis leishmaniasis measles
arthritis breast carcinoma leukemia breast cancer
carcinoma schizophrenia sepsis
1 disease from the University of Copenhagen DISEASES database for TAB2:Hypohidrosis 2 Novoseek disease relationships for TAB2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TAB2 (7 documents)
Export disorders for TAB2 gene to outside databases
|
Publications
for TAB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAB2 gene, integrated from 9 sources (see all 115):
(articles sorted by number of sources associating them with TAB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. (PubMed id 10882101)1, 2, 3, 9 Takaesu G....Matsumoto K. (2000)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1, 2, 9 Ishitani T....Matsumoto K. (2003)
- Two-sided ubiquitin binding explains specificity of t he TAB2 NZF domain. (PubMed id 19935683)1, 2, 9 Kulathu Y....Komander D. (2009)
- RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)1, 2, 9 Tian Y....Shu H.B. (2007)
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)1, 2, 9 Wang C.... Chen Z.J. (2001)
- TRIM5 is an innate immune sensor for the retrovirus c apsid lattice. (PubMed id 21512573)1, 2 Pertel T....Luban J. (2011)
- Haploinsufficiency of TAB2 causes congenital heart de fects in humans. (PubMed id 20493459)1, 2 Thienpont B....Larsen L.A. (2010)
- Direct activation of protein kinases by unanchored po lyubiquitin chains. (PubMed id 19675569)1, 2 Xia Z.P....Chen Z.J. (2009)
- WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2 Gao D....Chen D.Y. (2009)
|
External Searches for TAB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAB2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TAB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAB2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAB2 gene:
Search GeneIP for patents involving TAB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TAB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB2 | | | OriGene Protein Over-expression Lysate for TAB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAB2 | | OriGene 3'-UTR Clone for TAB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAB2 | | OriGene Custom Protein Services for TAB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB2 |
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| | Antibodies & Assays for TAB2 |
| | | | Search Tocris compounds for TAB2 |
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 | | | TAB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB2 |
|  |  |  | | | | ThermoFisher Antibodies for TAB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB2 |
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