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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAB2 Gene

protein-coding   GIFtS: 65
GCID: GC06P149543

TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2

(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 21 2     TGF-Beta-Activated Kinase 1-Binding Protein 22 3
MAP3K7IP21 2 3 5     CHTD22 5
Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 22 3     KIAA07333 5
TAB-22 3     Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 21
TAK1-Binding Protein 22 3     TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 22

External Ids:    HGNC: 170751   Entrez Gene: 231182   Ensembl: ENSG000000552087   OMIM: 6051015   UniProtKB: Q9NYJ83   

Export aliases for TAB2 gene to outside databases

Previous GC identifers: GC06P149639 GC06P147206 GC06P149540 GC06P149541


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAB2 Gene:
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced
activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and
TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the
signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB
(TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAB2 Gene: 
TAB2 (TGF-beta activated kinase 1/MAP3K7 binding protein 2) is a protein-coding gene. Diseases associated with TAB2 include congenital heart disease, nonsyndromic, 2, and hypohidrotic ectodermal dysplasia, and among its related super-pathways are NOD1/2 Signaling Pathway and Immune response TLR signaling pathways. GO annotations related to this gene include K63-linked polyubiquitin binding and zinc ion binding. An important paralog of this gene is TAB3.

UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8
Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The
binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'.
Involved in heart development

Gene Wiki entry for TAB2 (MAP3K7IP2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TAB2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

TAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAB2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P149543:  view genomic region     (about GC identifiers)

Start:
149,539,777 bp from pter      End:
149,732,749 bp from pter
Size:
192,973 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8 (See protein sequence)
Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2  
Size: 693 amino acids; 76494 Da
Subunit: Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.
Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts
(via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains).
Interacts with RBCK1. Interacts with TRIM5
Subcellular location: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation,
translocation occurs from the membrane to cytosol
Sequence caution: Sequence=BAA34453.2; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for TAB2:
2DAE (3D)        2WWZ (3D)        2WX0 (3D)        2WX1 (3D)    
Secondary accessions: B2RCC4 E1P5A0 O94838 Q6I9W8 Q76N06 Q9UFP7
Alternative splicing: 2 isoforms:  Q9NYJ8-1   Q9NYJ8-2   

Explore the universe of human proteins at neXtProt for TAB2: NX_Q9NYJ8

Explore proteomics data for TAB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to
    proteasomal degradation
  • UniProtKB: Phosphorylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYJ8

  • TAB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAB2 Protein Expression
    REFSEQ proteins: NP_055908.1  
    ENSEMBL proteins: 
     ENSP00000476139   ENSP00000475580   ENSP00000356426   ENSP00000432709   ENSP00000443206  
     ENSP00000445752   ENSP00000286332   ENSP00000376106  
    Reactome Protein details: Q9NYJ8
    Human Recombinant Protein Products for TAB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAB2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TAB2
    GenScript Custom Purified and Recombinant Proteins Services for TAB2
    Novus Biologicals TAB2 Protein
    Novus Biologicals TAB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--

    TAB2 for ontologies           About GeneDecksing



    TAB2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TAB2 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAB2
    GenScript Custom Superior Antibodies Services for TAB2
    Novus Biologicals TAB2 Antibodies
    Abcam antibodies for TAB2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for TAB2
    LSBio Antibodies in human, mouse, rat for TAB2 

    Assay Products for TAB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001876 Znf_RanBP2
     IPR003892 CUE

    Graphical View of Domain Structure for InterPro Entry Q9NYJ8

    ProtoNet protein and cluster: Q9NYJ8

    2 Blocks protein domains:
    IPB001876 Zn-finger
    IPB003892 Ubiquitin system component Cue


    UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8
    Domain: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins (By
    similarity)
    Similarity: Contains 1 CUE domain
    Similarity: Contains 1 RanBP2-type zinc finger


    TAB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAB2_HUMAN, Q9NYJ8
    Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The
    binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'.
    Involved in heart development

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11460167
    GO:0008270zinc ion binding IEA--
    GO:0016301kinase activity ----
    GO:0070530K63-linked polyubiquitin binding IDA19935683
         
    TAB2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tab2):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging 

    TAB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TAB2: Tab2tm1Brs Tab2tm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAB2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAB2:
    hsa-let-7b (MIRT005057), hsa-mir-155 (MIRT000289)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAB2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate TAB2 (see all 58):
    hsa-miR-124* hsa-miR-3130-5p hsa-let-7d hsa-miR-199a-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTAB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAB2
    Sirion Biotech Customized adenovirus for overexpression of TAB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TAB2 (see all 7)
    OriGene ORF clones in mouse, rat for TAB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAB2 (NM_015093)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB2
    Sirion Biotech Customized lentivirus for stable overexpression of TAB2 
                         Customized lentivirus expression plasmids for stable overexpression of TAB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAB2
    Search LifeMap BioReagents cell lines for TAB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAB2 About   (see all 36)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Interleukin-1 signaling
    IL1-mediated signaling events0.39
    Interleukin-1 signaling0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for TAB2
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    2 R&D Systems Pathways for TAB2
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways


    3 Cell Signaling Technology (CST) Pathways for TAB2
        MAP Kinase Signaling
    TGF-beta/Smad Signaling
    NF-kappaB Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for TAB2 (see all 7)
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    5/9 BioSystems Pathways for TAB2 (see all 9)
        MAPK signaling pathway
    Diurnally regulated genes with circadian orthologs
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    RANKL/RANK Signaling Pathway

    5/40        Reactome Pathways for TAB2 (see all 40)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    FCERI mediated NF-kB activation
    IRAK2 mediated activation of TAK1 complex
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    5/11         Kegg Pathways  (Kegg details for TAB2) (see all 11):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    TAB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for TAB2 (Q9NYJ81, 2, 3 ENSP000002863324) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7O433181, 2, 3, ENSP000003583354EBI-358708,EBI-358684 MINT-49214 MINT-8303915 MINT-48035 MINT-6797216 MINT-49239 MINT-2842686 MINT-8303890 I2D: score=8 STRING: ENSP00000358335
    BECN1Q144572, ENSP000003552314MINT-8304485 MINT-8304201 MINT-8304465 MINT-8304359 MINT-8327865 MINT-8304411 MINT-8304337 MINT-8304433 MINT-8304183 MINT-8303924 MINT-8303890 STRING: ENSP00000355231
    ENSG00000183311P074372, 3MINT-49205 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49205 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49205 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0007249I-kappaB kinase/NF-kappaB cascade TAS--

    TAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAB2

    2 Novoseek inferred chemical compound relationships for TAB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 99.4 130 20194509 (8), 14670075 (6), 19927120 (6), 19955178 (6) (see all 37)
    tab-1 96.9 20 16845370 (3), 15590691 (3), 14670075 (2), 11518704 (2) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about TAB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAB2 gene (2 alternative transcripts): 
    NM_015093.4  NM_145342.1  

    Unigene Cluster for TAB2:

    TGF-beta activated kinase 1/MAP3K7 binding protein 2
    Hs.269775  [show with all ESTs]
    Unigene Representative Sequence: NM_015093
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606202 ENST00000461481 ENST00000606797 ENST00000367456 ENST00000470466
    ENST00000484505 ENST00000536230 ENST00000538427(uc011eec.2 uc003qmj.3 uc010kia.1 uc010kib.2 uc003qmk.4)
    ENST00000286332 ENST00000392282
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAB2
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate TAB2 (see all 58):
    hsa-miR-124* hsa-miR-3130-5p hsa-let-7d hsa-miR-199a-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidTAB2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB2
    Clone
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    OriGene clones in human, mouse for TAB2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: TAB2 (NM_015093)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB2
    Sirion Biotech Customized lentivirus for stable overexpression of TAB2 
                         Customized lentivirus expression plasmids for stable overexpression of TAB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TAB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TAB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB2

    Additional mRNA sequence: 

    AB018276.2 AF241230.1 AK025538.1 AK295750.1 AK307650.1 AK315038.1 AL050180.1 BC035910.2 
    CR457387.1 

    6 DOTS entries:

    DT.100027704  DT.447352  DT.100678319  DT.100757599  DT.100788776  DT.91814258 

    24/313 AceView cDNA sequences (see all 313):

    F11185 NM_145342 AI628078 BM694003 BM841337 CD722379 BM755346 AL117407 
    BM562480 BM449932 AI379462 CA418565 BX644218 AA418767 BQ233388 NM_015093 
    AI887894 BQ879873 AA457253 BQ212617 BM970167 AI378599 CB215099 BU741612 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                      -                           
    SP2:                                                                  
    SP3:        -                                                         
    SP4:                                                                  


    ECgene alternative splicing isoforms for TAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAB2 expression in normal human tissues (normalized intensities)      TAB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATTTATA
    TAB2 Expression
    About this image


    TAB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             stem cells (umbilical cord cd34+)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See TAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAB2

    SOURCE GeneReport for Unigene cluster: Hs.269775

    UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8
    Tissue specificity: Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of
    the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TAB2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tab21 , 5 TGF-beta activated kinase 1/MAP3K7 binding protein more1, 5 91.44(n)1
    94.66(a)1
      10 (2.56 cM)5
    686521  NM_138667.31  NP_619608.11 
     79056535 
    chicken
    (Gallus gallus)
    Aves TAB21 TGF-beta activated kinase 1/MAP3K7 binding protein more 85.4(n)
    88.01(a)
      421622  XM_419660.2  XP_419660.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAB26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343259.1(94399-160137)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.172532 Xenopus laevis transcribed sequences 86.59(n)    48055137 
    zebrafish
    (Danio rerio)
    Actinopterygii tab26
    TGF-beta activated kinase 1/MAP3K7 binding protein...
    57(a)
    1 ↔ 1
    20(1352818-1373605)


    ENSEMBL Gene Tree for TAB2 (if available)
    TreeFam Gene Tree for TAB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAB2 gene
    TAB32  
    2 SIMAP similar genes for TAB2 using alignment to 2 protein entries:     TAB2_HUMAN (see all proteins):
    TAB3    DKFZp313L0918

    TAB2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TAB2
    PGOHUM00000238807 PGOHUM00000245310


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1886 SNPs in TAB2 are shown (see all 1886)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2676071001,2,4
    CCongenital heart disease, multiple types, 2 (CHTD2)4 pathogenic1162979148(+) AGACAA/CAACAG 2 K Q mis10--------
    rs1422398881,2
    C--147204427(+) AAAGC-/GTTAAA
            
    GTTAA
    1 -- us2k10--------
    rs357955591,2
    F--147204432(+) GTTAAAGTTAA/-
            
    TGATT
    1 -- us2k12Minor allele frequency- -:0.02NS 84
    rs1385390991,2
    --147204522(+) CACCAA/GTGGAG 1 -- us2k10--------
    rs1414970881,2
    C--147204653(+) AAGTGA/GGGAGA 1 -- us2k10--------
    rs1506959271,2
    --147204674(+) AACTGC/TGAGGA 1 -- us2k10--------
    rs2005326061,2
    C--147204700(+) AAGAT-/GGGTTT 1 -- us2k10--------
    rs342795681,2
    C,F--147204703(+) GATGGT/GTTAAA 1 -- us2k14Minor allele frequency- G:0.05NS NA WA 84
    rs347480171,2
    C,F--147204706(+) GGTTTA/TAAAAA 1 -- us2k13Minor allele frequency- T:0.04NS WA 84
    rs347306461,2
    C,F--147204854(+) TGCCCT/CAGTGT 1 -- us2k13Minor allele frequency- C:0.04NS WA 76

    HapMap Linkage Disequilibrium report for TAB2 (149539777 - 149732749 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675622CNV Deletion23128226
    nsv522875CNV Loss19592680
    nsv517889CNV Loss19592680


    Human Gene Mutation Database (HGMD): TAB2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605101   
    OMIM disorders: 612863  
    UniProtKB/Swiss-Prot: TAB2_HUMAN, Q9NYJ8
  • Congenital heart disease, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital
    developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract
    obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and
    aortic dilation. Note=The disease is caused by mutations affecting the gene represented in this entry. A
    chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation
    t(2;6)(q21;q25)

  • 17 diseases for TAB2:    About MalaCards
    congenital heart disease, nonsyndromic, 2    hypohidrotic ectodermal dysplasia    hypohidrosis    ectodermal dysplasia
    toxoplasmosis    kawasaki disease    measles    leishmaniasis
    graves' disease    type 1 diabetes    chronic lymphocytic leukemia    schizophrenia
    rheumatoid arthritis    arthritis    endotheliitis    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TAB2:
    Hypohidrosis

    TAB2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TAB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 34.9 5 18786322 (1), 18021073 (1), 15836773 (1)
    tumors 3.18 4 18786322 (1), 15836773 (1)

    Genetic Association Database (GAD): TAB2
    Human Genome Epidemiology (HuGE) Navigator: TAB2 (7 documents)

    Export disorders for TAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAB2 gene, integrated from 9 sources (see all 123):
    (articles sorted by number of sources associating them with TAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. (PubMed id 10882101)1, 2, 3, 9 Takaesu G....Matsumoto K. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1, 2, 9 Ishitani T....Matsumoto K. (2003)
    4. Two-sided ubiquitin binding explains specificity of t he TAB2 NZF domain. (PubMed id 19935683)1, 2, 9 Kulathu Y....Komander D. (2009)
    5. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)1, 2, 9 Tian Y....Shu H.B. (2007)
    6. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)1, 2, 9 Wang C.... Chen Z.J. (2001)
    7. TRIM5 is an innate immune sensor for the retrovirus c apsid lattice. (PubMed id 21512573)1, 2 Pertel T....Luban J. (2011)
    8. Haploinsufficiency of TAB2 causes congenital heart de fects in humans. (PubMed id 20493459)1, 2 Thienpont B....Larsen L.A. (2010)
    9. Direct activation of protein kinases by unanchored po lyubiquitin chains. (PubMed id 19675569)1, 2 Xia Z.P....Chen Z.J. (2009)
    10. WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2 Gao D....Chen D.Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23118 HGNC: 17075 AceView: MAP3K7IP2 Ensembl:ENSG00000055208 euGenes: HUgn23118
    ECgene: TAB2 Kegg: 23118 H-InvDB: TAB2

    (According to HUGE)
    About This Section
    HUGE: KIAA0733

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAB2 gene:
    Search GeneIP for patents involving TAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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