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Aliases for TAB2 Gene

Aliases for TAB2 Gene

  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2 2 3
  • MAP3K7IP2 3 4 6
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 2 3 4
  • TAK1-Binding Protein 2 3 4
  • KIAA0733 4 6
  • CHTD2 3 6
  • TAB-2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 2 2
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 2 3
  • TGF-Beta-Activated Kinase 1-Binding Protein 2 4

External Ids for TAB2 Gene

Previous HGNC Symbols for TAB2 Gene

  • MAP3K7IP2

Previous GeneCards Identifiers for TAB2 Gene

  • GC06P149639
  • GC06P147206
  • GC06P149540
  • GC06P149541
  • GC06P149543

Summaries for TAB2 Gene

Entrez Gene Summary for TAB2 Gene

  • The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for TAB2 Gene

TAB2 (TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 2) is a Protein Coding gene. Diseases associated with TAB2 include congenital heart defects, nonsyndromic, 2 and hypohidrosis. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include K63-linked polyubiquitin binding. An important paralog of this gene is TAB3.

UniProtKB/Swiss-Prot for TAB2 Gene

  • Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of Lys-63-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at Thr-187. Involved in heart development.

Gene Wiki entry for TAB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB2 Gene

Genomics for TAB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAB2 Gene

Start:
149,218,641 bp from pter
End:
149,411,613 bp from pter
Size:
192,973 bases
Orientation:
Plus strand

Genomic View for TAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB2 Gene

No data available for Regulatory Elements for TAB2 Gene

Proteins for TAB2 Gene

  • Protein details for TAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYJ8-TAB2_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    Protein Accession:
    Q9NYJ8
    Secondary Accessions:
    • B2RCC4
    • E1P5A0
    • O94838
    • Q6I9W8
    • Q76N06
    • Q9UFP7

    Protein attributes for TAB2 Gene

    Size:
    693 amino acids
    Molecular mass:
    76494 Da
    Quaternary structure:
    • Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds Lys-63-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TRIM5.
    SequenceCaution:
    • Sequence=BAA34453.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAB2 Gene

    Alternative splice isoforms for TAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB2 Gene

Proteomics data for TAB2 Gene at MOPED

Post-translational modifications for TAB2 Gene

  • Phosphorylated.
  • Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
  • Ubiquitination at Lys656
  • Modification sites at PhosphoSitePlus

Other Protein References for TAB2 Gene

No data available for DME Specific Peptides for TAB2 Gene

Domains for TAB2 Gene

Protein Domains for TAB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYJ8

UniProtKB/Swiss-Prot:

TAB2_HUMAN :
  • Q9NYJ8
Domain:
  • The RanBP2-type zinc finger (NZF) mediates binding to two consecutive Lys-63-linked ubiquitins.
  • Contains 1 CUE domain.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with TAB2: view

No data available for Gene Families for TAB2 Gene

Function for TAB2 Gene

Molecular function for TAB2 Gene

UniProtKB/Swiss-Prot Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of Lys-63-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at Thr-187. Involved in heart development.

Gene Ontology (GO) - Molecular Function for TAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11460167
GO:0008270 zinc ion binding IEA --
GO:0070530 K63-linked polyubiquitin binding IDA 19935683
genes like me logo Genes that share ontologies with TAB2: view
genes like me logo Genes that share phenotypes with TAB2: view

Animal Models for TAB2 Gene

MGI Knock Outs for TAB2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAB2 Gene

Localization for TAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAB2 Gene

Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAB2 Gene COMPARTMENTS Subcellular localization image for TAB2 gene
Compartment Confidence
cytosol 5
endosome 4
plasma membrane 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TAB2: view

Pathways for TAB2 Gene

genes like me logo Genes that share pathways with TAB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB2: view

Compounds for TAB2 Gene

(2) Novoseek inferred chemical compound relationships for TAB2 Gene

Compound -log(P) Hits PubMed IDs
tab-2 99.4 112
tab-1 96.9 18
genes like me logo Genes that share compounds with TAB2: view

Transcripts for TAB2 Gene

Unigene Clusters for TAB2 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for TAB2 Gene

GeneLoc Exon Structure for
TAB2
ECgene alternative splicing isoforms for
TAB2

Expression for TAB2 Gene

mRNA expression in normal human tissues for TAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TAB2 Gene

SOURCE GeneReport for Unigene cluster for TAB2 Gene Hs.269775

mRNA Expression by UniProt/SwissProt for TAB2 Gene

Q9NYJ8-TAB2_HUMAN
Tissue specificity: Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
genes like me logo Genes that share expressions with TAB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAB2 Gene

Orthologs for TAB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAB2 35
  • 99.71 (n)
  • 100 (a)
TAB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAB2 35
  • 94.56 (n)
  • 96.68 (a)
TAB2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAB2 35
  • 95.05 (n)
  • 96.54 (a)
TAB2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tab2 35
  • 91.44 (n)
  • 94.66 (a)
Tab2 16
Tab2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAB2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tab2 35
  • 90.11 (n)
  • 93.71 (a)
chicken
(Gallus gallus)
Aves TAB2 35
  • 85.31 (n)
  • 88.01 (a)
TAB2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAB2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17253 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tab2 35
  • 76.71 (n)
  • 79.24 (a)
zebrafish
(Danio rerio)
Actinopterygii tab2 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10639 36
  • 31 (a)
OneToMany
Species with no ortholog for TAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAB2 Gene

ENSEMBL:
Gene Tree for TAB2 (if available)
TreeFam:
Gene Tree for TAB2 (if available)

Paralogs for TAB2 Gene

Paralogs for TAB2 Gene

Selected SIMAP similar genes for TAB2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TAB2 Gene

genes like me logo Genes that share paralogs with TAB2: view

Variants for TAB2 Gene

Sequence variations from dbSNP and Humsavar for TAB2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7896 -- 149,410,340(+) TACCC(C/G)AAAGC utr-variant-3-prime
rs47546 -- 149,297,532(+) Ctttt(C/T)tttct intron-variant
rs92605 -- 149,339,132(+) aggcc(A/G)agacg intron-variant
rs237011 -- 149,408,993(-) CATTT(A/G)GTATG intron-variant
rs237012 -- 149,408,062(-) TACTA(A/G)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAB2 Gene

Variant ID Type Subtype PubMed ID
nsv522875 CNV Loss 19592680
nsv517889 CNV Loss 19592680
esv2675622 CNV Deletion 23128226

Relevant External Links for TAB2 Gene

HapMap Linkage Disequilibrium report
TAB2
Human Gene Mutation Database (HGMD)
TAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB2 Gene

Disorders for TAB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TAB2 Gene including...

Search for TAB2 Gene in MalaCards »

(1) OMIM Diseases for TAB2 Gene (605101)

UniProtKB/Swiss-Prot

TAB2_HUMAN
  • Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. {ECO:0000269 PubMed:20493459}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).

(1) University of Copenhagen DISEASES for TAB2 Gene

(2) Novoseek inferred disease relationships for TAB2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 34.9 3
tumors 3.18 2

Relevant External Links for TAB2

Genetic Association Database (GAD)
TAB2
Human Genome Epidemiology (HuGE) Navigator
TAB2
genes like me logo Genes that share disorders with TAB2: view

Publications for TAB2 Gene

  1. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. (PMID: 10882101) Takaesu G. … Matsumoto K. (Mol. Cell 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C. … Chen Z.J. (Nature 2001) 3 4 23
  4. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PMID: 14633987) Ishitani T. … Matsumoto K. (EMBO J. 2003) 3 4 23
  5. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1- triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PMID: 17449468) Tian Y. … Shu H.B. (J. Biol. Chem. 2007) 3 4 23

Products for TAB2 Gene

Sources for TAB2 Gene

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