TAB1 Gene
protein-coding GIFtS: 60
GCID: GC22P039796
|
|
TGF-beta activated kinase 1/MAP3K7 binding protein 1(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP1)
| |
Aliases
for TAB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 11 2 | | 3'-Tab12 | | MAP3K7IP11 2 3 5 | | TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 12 | | Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 12 3 | | Transforming Growth Factor Beta-Activated Kinase-Binding Protein 12 | | TAK1-Binding Protein 12 3 | | TGF-Beta-Activated Kinase 1-Binding Protein 13 | | Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 11 | | |
Export aliases for TAB1 gene to outside databasesPrevious GC identifer: GC22P022760 |
Summaries
for TAB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAB1:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which isknown to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, andWNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of thisprotein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as adominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF betareceptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14(MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, whichcontributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variantsencoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important rolein mammalian embryogenesis
Gene Wiki entry for TAB1 (MAP3K7IP1)
|
Genomic Views
for TAB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TAB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1TAB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P039796: view genomic region
(about GC identifiers)
Start:
|
39,795,746 bp from pter |
End:
|
39,913,596 bp from pter |
Size:
|
117,851 bases |
Orientation:
|
plus strand |
|
Proteins
for TAB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750 (See
protein sequence)Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Size: 504 amino acids; 54644 Da
Subunit: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in theTRIKA2 complex composed of MAP3K7, TAB1 and TAB2
Caution: Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphataseactivity
6/7 PDB 3D structures from  and Proteopedia  for TAB1 (see all 7):2J4O (3D)
2POM (3D)
2POP (3D)
2YIY (3D)
4AY5 (3D)
4AY6 (3D)
Secondary accessions: Q2PP09 Q8IZW2Alternative splicing: 2 isoforms: Q15750-1 Q15750-2 (Does not bind nor activate MAP3K7/TAK1)Explore the universe of human proteins at neXtProt for TAB1: NX_Q15750
Post-translational modifications:
Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15750
TAB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_006107.1 NP_705717.1
ENSEMBL proteins: ENSP00000216160 ENSP00000333049 ENSP00000417054 ENSP00000418850 Reactome Protein details: Q15750
Human Recombinant Protein Products for TAB1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TAB1 for ontologies About GeneDecksing
TAB1 Antibody Products:
Assay Products for TAB1: |
Protein
Domains /
Families
for TAB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAB1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15750ProtoNet protein and cluster: Q15750 UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750Similarity: Contains 1 PP2C-like domain |
Function
for TAB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TAB1_HUMAN, Q15750Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important rolein mammalian embryogenesis Genatlas biochemistry entry for TAB1:transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signalingthrough binding with API3 (XIAP)
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TAB1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TAB1:
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Tab1):
TAB1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TAB1: Tab1tm1.1Mis Tab1tm1Geny
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1 |
|
Pathways & Interactions
for TAB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | | | 3 | Development_CNTF receptor signaling | | | 4 | Immune response_Bacterial infections in normal airways | | | 5 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for TAB1 (see all 6)
1  R&D Systems Pathway for TAB1
3 
Cell Signaling Technology (CST) Pathways for TAB1
5/10  GeneGo (Thomson Reuters) Pathways for TAB1 (see all 10)
5/12  BioSystems Pathways for TAB1 (see all 12)
5/34 
Reactome Pathways for TAB1 (see all 34)
5/6 
Kegg Pathways (Kegg details for TAB1) (see all 6):
TAB1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/185 Interacting proteins for TAB1 (Q157502, 3 ENSP000002161604) via UniProtKB, MINT, STRING, and/or I2D (see all 185)About this table
Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000185 | activation of MAPKKK activity |
IEA | -- | | GO:0000187 | activation of MAPK activity |
TAS | -- | | GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- |
TAB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TAB1 for compounds About GeneDecksing
 Browse Tocris compounds for TAB1
3 Novoseek chemical compound relationships for TAB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TAB1
|
Transcripts
for TAB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAB1 gene (2 alternative transcripts): NM_006116.2 NM_153497.2 Unigene Cluster for TAB1: TGF-beta activated kinase 1/MAP3K7 binding protein 1 Hs.507681 [show with all ESTs]Unigene Representative Sequence: BC0385829 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216160(uc003axr.3 uc003axt.3 uc011aok.2) ENST00000473613
ENST00000331454(uc003axu.1) ENST00000461775 ENST00000462277 ENST00000480990
ENST00000490819 ENST00000473491 ENST00000488859(uc021wpx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1 |
Additional cDNA sequence: AF425640.1 AK291668.1 AK296314.1 AK308903.1 AK312456.1 AK316004.1 BC038582.1 BC050554.1 EF036484.1 U49928.1 13 DOTS entries: DT.416823 DT.100024651 DT.100841680 DT.97779153 DT.100841682 DT.100032803 DT.100841688 DT.100694188 DT.120645251 DT.91985224 DT.99966152 DT.100714323 DT.97805216 24/230 AceView cDNA sequences (see all 230): BQ929862 H45303 AA744944 BC050554 BQ917606 BU624204 AA458466 BX375824 AW613952 AA253016 BE018709 CF125613 BC038582 BX324983 BX396811 AA555204 BQ644850 BM752202 AA806471 CD622011 AY007145 BM699054 AL110379 BX328210
GeneLoc Exon Structure
|
Expression
for TAB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCTCTTCT
About this image
See TAB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAB1
SOURCE GeneReport for Unigene cluster: Hs.507681
UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including TAB1: | Toll-Like Receptor Signaling Pathway in human mouse rat | | Inflammasomes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1 |
Orthologs
for TAB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAB1 gene from 7/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tab11 , 5 |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 less1, 5 |
88.71(n)1
97.61(a)1 |
|
15 (37.85 cM)5
665131 NM_025609.21 NP_079885.21
801331545 |
chicken
(Gallus gallus) |
Aves |
TAB11 |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 less |
80.09(n)
89.02(a) |
|
418014 NM_001006240.1 NP_001006240.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TAB16 |
-- |
89(a) |
1 ↔ 1 |
5(24706949-24725150) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3980252 |
TAB1 |
75.37(n) |
|
U92031.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.167542 |
Danio rerio TAK1-binding protein 1, mRNA (cDNA clone IMAGE6790544) less |
75.47(n) |
|
BC058295.1 |
mosquito
(Anopheles gambiae) |
Insecta |
AgaP_AGAP0029531 |
AGAP002953-PA |
48.34(n)
40.6(a) |
|
1273010 XM_311946.4 XP_311946.4 |
worm
(Caenorhabditis elegans) |
Secernentea |
tap-16 |
TAK1 kinase/MOM-4 binding Protein family member (t... |
23(a) |
1 ↔ 1 |
X(14589567-14591894) |
ENSEMBL Gene Tree for TAB1 (if available)
TreeFam Gene Tree for TAB1 (if available) |
Paralogs
for TAB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TAB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAB1 (39795746 - 39913596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB1 |
|
Disorders
/ Diseases
for TAB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAB1 for disorders About GeneDecksing
OMIM gene information: 602615
OMIM disorders: --
16  diseases for TAB1: About MalaCardsprimary biliary cirrhosis metastasis efficiency kaposi's sarcoma kawasaki disease
embryonal carcinoma rheumatoid arthritis toxoplasmosis crohn's disease
leishmaniasis breast cancer sarcoma arthritis
prostate cancer ischemia prostatitis carcinoma
3 Novoseek disease relationships for TAB1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
39.2 |
2 |
12488458 (1), 18566231 (1) |
| tumors |
10.1 |
1 |
18566231 (1) |
| breast cancer |
7.5 |
2 |
18316610 (2) |
Human Genome Epidemiology (HuGE) Navigator: TAB1 (3 documents)
Export disorders for TAB1 gene to outside databases
|
Publications
for TAB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAB1 gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with TAB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PubMed id 8638164)1, 2, 3, 9 Shibuya H.... Matsumoto K. (1996)
- TAB1beta (transforming growth factor-beta-activated protein kinase 1- binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PubMed id 12429732)1, 2, 9 Ge B....Han J. (2003)
- TAK1-binding protein 1 is a pseudophosphatase. (PubMed id 16879102)1, 2, 9 Conner S.H....Van Aalten D.M. (2006)
- Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation . (PubMed id 10187861)1, 3, 9 Sakurai H....Sugita T. (1999)
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)1, 2, 9 Wang C.... Chen Z.J. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. (PubMed id 10094049)1, 2 Ninomiya-Tsuji J....Matsumoto K. (1999)
- Determinants that control the specific interactions between TAB1 and p38alpha. (PubMed id 16648477)1, 9 Zhou H....Han J. (2006)
- The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PubMed id 16845370)2, 9 Thiefes A....Kracht M. (2006)
|
External Searches for TAB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAB1 gene:
Search GeneIP for patents involving TAB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for TAB1 | | OriGene shRNA RFP for TAB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAB1 | | | OriGene Protein Over-expression Lysate for TAB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAB1 | | OriGene 3'-UTR Clone for TAB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TAB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAB1 | | OriGene Custom Protein Services for TAB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB1 |
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| | Antibodies & Assays for TAB1 |
| | | | Search Tocris compounds for TAB1 |
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 | | | TAB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1 |
|  |  |  |  | | | | ThermoFisher Antibody for TAB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1 |
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