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Aliases for TAB1 Gene

Aliases for TAB1 Gene

  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1 2 3
  • TAK1-Binding Protein 1 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
  • MAP3K7IP1 3 4
  • Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 1 3
  • TGF-Beta-Activated Kinase 1-Binding Protein 1 4
  • MAP3K7IP1, 6
  • 3-Tab1 3

External Ids for TAB1 Gene

Previous Symbols for TAB1 Gene

  • MAP3K7IP1

Summaries for TAB1 Gene

Entrez Gene Summary for TAB1 Gene

  • The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB1 Gene

TAB1 (TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include enzyme activator activity and kinase activator activity.

UniProtKB/Swiss-Prot for TAB1 Gene

  • May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis

Gene Wiki entry for TAB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB1 Gene

Genomics for TAB1 Gene

Genomic Location for TAB1 Gene

Start:
39,399,741 bp from pter
End:
39,437,127 bp from pter
Size:
37,387 bases
Orientation:
Plus strand

Genomic View for TAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB1 Gene

No data available for Regulatory Elements for TAB1 Gene

Proteins for TAB1 Gene

  • Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15750-TAB1_HUMAN
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Protein Accession:
    Q15750
    Secondary Accessions:
    • Q2PP09
    • Q8IZW2

    Protein attributes for TAB1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54644 Da
    Quaternary structure:
    • Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.

    Three dimensional structures from OCA and Proteopedia for TAB1 Gene

    Alternative splice isoforms for TAB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAB1 Gene

Proteomics data for TAB1 Gene at MOPED

Post-translational modifications for TAB1 Gene

  • Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys150 and Lys264

Other Protein References for TAB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAB1 Gene

Domains for TAB1 Gene

Protein Domains for TAB1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TAB1_HUMAN
Domain:
  • Contains 1 PPM-type phosphatase domain.:
    • Q15750
genes like me logo Genes that share domains with TAB1: view

No data available for Gene Families for TAB1 Gene

Function for TAB1 Gene

Molecular function for TAB1 Gene

GENATLAS Biochemistry: transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
UniProtKB/Swiss-Prot Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis

Gene Ontology (GO) - Molecular Function for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 10094049
GO:0008047 enzyme activator activity TAS 8638164
GO:0019209 kinase activator activity IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TAB1: view
genes like me logo Genes that share phenotypes with TAB1: view

Animal Models for TAB1 Gene

MGI Knock Outs for TAB1:

miRNA for TAB1 Gene

miRTarBase miRNAs that target TAB1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAB1 Gene

Localization for TAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAB1 Gene COMPARTMENTS Subcellular localization image for TAB1 gene
Compartment Confidence
cytosol 4
endosome 4
nucleus 2
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with TAB1: view

Pathways for TAB1 Gene

genes like me logo Genes that share pathways with TAB1: view

Gene Ontology (GO) - Biological Process for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0001701 in utero embryonic development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB1: view

Compounds for TAB1 Gene

(3) Novoseek inferred chemical compound relationships for TAB1 Gene

Compound -log(P) Hits PubMed IDs
tab-1 99.5 137
tab-2 96.6 18
sb 203580 52.9 1
genes like me logo Genes that share compounds with TAB1: view

Transcripts for TAB1 Gene

Unigene Clusters for TAB1 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAB1 Gene

No ASD Table

Relevant External Links for TAB1 Gene

GeneLoc Exon Structure for
TAB1
ECgene alternative splicing isoforms for
TAB1

Expression for TAB1 Gene

mRNA expression in normal human tissues for TAB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAB1 Gene

SOURCE GeneReport for Unigene cluster for TAB1 Gene Hs.507681

mRNA Expression by UniProt/SwissProt for TAB1 Gene

Q15750-TAB1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TAB1: view

Orthologs for TAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAB1 36
  • 99.53 (n)
  • 100 (a)
TAB1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP3K7IP1 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAB1 36
  • 90.03 (n)
  • 97.39 (a)
TAB1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tab1 36
  • 88.71 (n)
  • 97.61 (a)
Tab1 16
Tab1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAB1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAB1 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tab1 36
  • 87.45 (n)
  • 96.61 (a)
chicken
(Gallus gallus)
Aves TAB1 36
  • 80.09 (n)
  • 89.02 (a)
TAB1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAB1 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398025 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tab1 36
  • 71.07 (n)
  • 77.24 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16754 36
tab1 36
  • 66 (n)
  • 65.91 (a)
tab1 37
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002953 36
  • 49.07 (n)
  • 40.93 (a)
worm
(Caenorhabditis elegans)
Secernentea tap-1 37
  • 26 (a)
OneToOne
Species with no ortholog for TAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAB1 Gene

ENSEMBL:
Gene Tree for TAB1 (if available)
TreeFam:
Gene Tree for TAB1 (if available)

Paralogs for TAB1 Gene

Selected SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAB1: view

No data available for Paralogs for TAB1 Gene

Variants for TAB1 Gene

Sequence variations from dbSNP and Humsavar for TAB1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs739141 -- 39,428,445(+) GGTTT(C/T)CTTTC intron-variant
rs743838 -- 39,428,702(-) TTCTA(A/C)GGAAG intron-variant
rs1297236 -- 39,401,056(+) aaaaa(A/C)Cgaaa intron-variant
rs2105894 -- 39,423,345(+) catgc(C/T)tgtaa intron-variant
rs2187796 -- 39,421,042(+) CCTGC(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAB1 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV Loss 17160897
nsv834199 CNV Loss 17160897
nsv915098 CNV Loss 21882294
nsv915099 CNV Loss 21882294
esv2724254 CNV Deletion 23290073
nsv471200 CNV Loss 18288195
esv2724255 CNV Deletion 23290073
nsv3628 CNV Insertion 18451855

Relevant External Links for TAB1 Gene

HapMap Linkage Disequilibrium report
TAB1

Disorders for TAB1 Gene

(3) Novoseek inferred disease relationships for TAB1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 39.2 2
tumors 10.1 1
breast cancer 7.5 2

Relevant External Links for TAB1

Human Genome Epidemiology (HuGE) Navigator
TAB1
genes like me logo Genes that share disorders with TAB1: view

No data available for UniProtKB/Swiss-Prot for TAB1 Gene

Publications for TAB1 Gene

  1. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H. … Matsumoto K. (Science 1996) 2 3 4 23
  2. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. (PMID: 10187861) Sakurai H. … Sugita T. (J. Biol. Chem. 1999) 2 3 23
  3. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C. … Chen Z.J. (Nature 2001) 3 4 23
  4. TAB1beta (transforming growth factor-beta-activated protein kinase 1- binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B. … Han J. (J. Biol. Chem. 2003) 3 4 23
  5. TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner S.H. … Van Aalten D.M.F. (Biochem. J. 2006) 3 4 23

Products for TAB1 Gene

Sources for TAB1 Gene

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