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TAB1 Gene

protein-coding   GIFtS: 61
GCID: GC22P039796

TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1

(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 11 2     3'-Tab12
MAP3K7IP11 2 3 5     TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 12
TAK1-Binding Protein 11 2 3     Transforming Growth Factor Beta-Activated Kinase-Binding Protein 12
Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 12 3     TGF-Beta-Activated Kinase 1-Binding Protein 13
Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 11     

External Ids:    HGNC: 181571   Entrez Gene: 104542   Ensembl: ENSG000001003247   OMIM: 6026155   UniProtKB: Q157503   

Export aliases for TAB1 gene to outside databases

Previous GC identifer: GC22P022760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAB1 Gene:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which
is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1,
and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion
of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a
dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta
receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14
(MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways,
which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript
variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAB1 Gene:
TAB1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1) is a protein-coding gene. GO annotations related to this gene include enzyme activator activity and kinase activator activity.

UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important
role in mammalian embryogenesis

Gene Wiki entry for TAB1 (MAP3K7IP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TAB1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAB1 promoter sequence
   Search Chromatin IP Primers for TAB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

TAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAB1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039796:  view genomic region     (about GC identifiers)

Start:
39,795,746 bp from pter      End:
39,833,132 bp from pter
Size:
37,387 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750 (See protein sequence)
Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1  
Size: 504 amino acids; 54644 Da
Subunit: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the
TRIKA2 complex composed of MAP3K7, TAB1 and TAB2
Caution: Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost
phosphatase activity
Selected PDB 3D structures from and Proteopedia for TAB1 (see all 11):
2J4O (3D)        2POM (3D)        2POP (3D)        2YDS (3D)        2YIY (3D)        4AY5 (3D)    
Secondary accessions: Q2PP09 Q8IZW2
Alternative splicing: 2 isoforms:  Q15750-1   Q15750-2   (Does not bind nor activate MAP3K7/TAK1)

Explore the universe of human proteins at neXtProt for TAB1: NX_Q15750

Explore proteomics data for TAB1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP1
  • Ubiquitination2 at Lys150, Lys264
  • Modification sites at PhosphoSitePlus

  • See TAB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006107.1  NP_705717.1  

    ENSEMBL proteins: 
     ENSP00000216160   ENSP00000333049  
    Reactome Protein details: Q15750

    TAB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for TAB1
    OriGene Protein Over-expression Lysate for TAB1
    OriGene MassSpec for TAB1
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    Novus Biologicals TAB1 Proteins
    Novus Biologicals TAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TAB1 

     
    antibodies-online proteins for TAB1 (5 products) 

     
    antibodies-online peptides for TAB1

    TAB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TAB1
    R&D Systems Antibodies for TAB1
    Cell Signaling Technology (CST) Antibodies for TAB1 
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    Novus Biologicals TAB1 Antibodies
    Abcam antibodies for TAB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TAB1
    LSBio Antibodies in human, mouse, rat for TAB1
    antibodies-online antibodies for TAB1 (110 products) 

    TAB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TAB1 
    antibodies-online kits for TAB1 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry Q15750

    ProtoNet protein and cluster: Q15750

    UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
    Similarity: Contains 1 PP2C-like domain


    Find genes that share domains with TAB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAB1_HUMAN, Q15750
    Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important
    role in mammalian embryogenesis

         Genatlas biochemistry entry for TAB1:
    transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP
    signaling through binding with API3 (XIAP)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI10094049
    GO:0008047enzyme activator activity TAS8638164
    GO:0019209kinase activator activity IEA--
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with TAB1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAB1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tab1):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  muscle 
     normal  respiratory system  skeleton 

    Find genes that share phenotypes with TAB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TAB1: Tab1tm1.1Mis Tab1tm1Geny

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAB1:
    hsa-mir-30d-5p (MIRT047792)

    Block miRNA regulation of human, mouse, rat TAB1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TAB1:
    hsa-miR-622 hsa-miR-3118 hsa-miR-134 hsa-miR-516a-3p hsa-miR-516b* hsa-miR-518f* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidTAB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAB1
    Predesigned siRNA for gene silencing in human, mouse, rat TAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAB1

    Clone
    Products:
         
    OriGene clones in human, mouse for TAB1 (see all 14)
    OriGene ORF clones in mouse, rat for TAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    nucleus2
    chloroplast1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    Find genes that share ontologies with TAB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAB1 About   (see all 35)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    IL-1 Family Signaling Pathways0.44
    2MAPK targets/ Nuclear events mediated by MAP kinases
    MAP kinase activation in TLR cascade0.61
    activated TAK1 mediates p38 MAPK activation0.00
    MAP Kinase Signaling0.31
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK10.00
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    IL 1 beta dependent CFTR expression0.43
    4Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    5Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68


    Find genes that share SuperPaths with TAB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for TAB1
        NOD-like Receptor Signaling Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAB1 (see all 12)
        Toll-Like Receptors Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer
    TGF-Beta Pathway
    Signaling Involved in Cardiac Hypertrophy

    3 Cell Signaling Technology (CST) Pathways for TAB1
        MAP Kinase Signaling
    TGF-beta/Smad Signaling
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TAB1 (see all 10)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways
    Development TGF-beta receptor signaling

    Selected BioSystems Pathways for TAB1 (see all 13)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Integrated Breast Cancer Pathway
    TGF-beta Receptor Signaling Pathway
    Toll-like receptor signaling pathway

    Selected Reactome Pathways for TAB1 (see all 9)
        Interleukin-1 signaling
    activated TAK1 mediates p38 MAPK activation
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
    FCERI mediated NF-kB activation


    Selected Kegg Pathways  (Kegg details for TAB1) (see all 10):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAB1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAB1 (Q157501, 2, 3 ENSP000002161604) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074372, 3, ENSP000004100714MINT-49174 I2D: score=2 STRING: ENSP00000410071
    MAP3K7O43318-21, ENSP000003583354EBI-358643,EBI-358700 MINT-6797194 MINT-49229 MINT-49178 MINT-6797216 MINT-2842623 MINT-48034 I2D: score=6 STRING: ENSP00000358335
    ENSG00000183311P074372, 3MINT-49174 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49174 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49174 I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IEA--
    GO:0000187activation of MAPK activity TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with TAB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAB1

    3 Novoseek inferred chemical compound relationships for TAB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 99.5 184 17205106 (10), 12429732 (8), 17932218 (7), 17052891 (6) (see all 51)
    tab-2 96.6 20 16845370 (3), 15590691 (3), 14670075 (2), 11518704 (2) (see all 12)
    sb 203580 52.9 1 17932218 (1)



    Find genes that share compounds with TAB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAB1 gene (2 alternative transcripts): 
    NM_006116.2  NM_153497.2  

    Unigene Cluster for TAB1:

    TGF-beta activated kinase 1/MAP3K7 binding protein 1
    Hs.507681  [show with all ESTs]
    Unigene Representative Sequence: BC038582
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216160(uc003axr.3 uc003axt.3 uc011aok.2) ENST00000473613
    ENST00000331454(uc003axu.1) ENST00000461775 ENST00000490819 ENST00000473491
    ENST00000488859(uc021wpx.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat TAB1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TAB1:
    hsa-miR-622 hsa-miR-3118 hsa-miR-134 hsa-miR-516a-3p hsa-miR-516b* hsa-miR-518f* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidTAB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAB1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1
    Primer
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    OriGene qPCR primer pairs and template standards for TAB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TAB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAB1
      QuantiTect SYBR Green Assays in human, mouse, rat TAB1
      QuantiFast Probe-based Assays in human, mouse, rat TAB1

    Additional mRNA sequence: 

    AF425640.1 AK291668.1 AK296314.1 AK308903.1 AK312456.1 AK316004.1 BC038582.1 BC050554.1 
    EF036484.1 U49928.1 

    13 DOTS entries:

    DT.416823  DT.100024651  DT.100841680  DT.97779153  DT.100841682  DT.100032803  DT.100841688  DT.100694188 
    DT.120645251  DT.91985224  DT.99966152  DT.100714323  DT.97805216 

    Selected AceView cDNA sequences (see all 230):

    AA253016 BU838481 AI827837 AL110379 BX328210 BC038582 AY007145 BM699054 
    CD622011 F08391 CB045510 BX380141 NM_153497 BX358000 AI563940 BX432385 
    BQ645086 BQ050651 BQ025572 Z43346 Z41387 F02762 BQ431917 NM_006116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCTTCT
    TAB1 Expression
    About this image

    TAB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507681

    UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAB1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TAB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TAB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAB1
    QuantiTect SYBR Green Assays in human, mouse, rat TAB1
    QuantiFast Probe-based Assays in human, mouse, rat TAB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tab11 , 5 TGF-beta activated kinase 1/MAP3K7 binding protein more1, 5 88.71(n)1
    97.61(a)1
      15 (37.85 cM)5
    665131  NM_025609.21  NP_079885.21 
     801331545 
    chicken
    (Gallus gallus)
    Aves TAB11 TGF-beta activated kinase 1/MAP3K7 binding protein more 80.09(n)
    89.02(a)
      418014  NM_001006240.1  NP_001006240.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAB16
    TGF-beta activated kinase 1/MAP3K7 binding protein...
    83(a)
    1 ↔ 1
    5(24706847-24726981)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980252 TAB1 75.37(n)    U92031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167542 Danio rerio TAK1-binding protein 1, mRNA (cDNA clone more 75.47(n)    BC058295.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0029531 AgaP_AGAP002953 49.07(n)
    40.93(a)
      1273010  XM_311946.5  XP_311946.5 
    worm
    (Caenorhabditis elegans)
    Secernentea tap-16
    Protein TAP-1 (tap-1) mRNA, complete cds
    26(a)
    1 ↔ 1
    X(14589636-14591963) WBGene00006524


    ENSEMBL Gene Tree for TAB1 (if available)
    TreeFam Gene Tree for TAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAB1 gene
    1 SIMAP similar gene for TAB1 using alignment to 1 protein entry:     TAB1_HUMAN:
    MAP3K7IP1

    Find genes that share paralogs with TAB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAB1 (see all 999)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899367791,2
    C--22758444(+) ACCTCA/GGCCTC 2 -- us2k10--------
    rs43864221,2
    C,F--22758483(+) CACCGT/CGCCCA 2 -- us2k18Minor allele frequency- C:0.05WA NA CSA EA 134
    rs1825640271,2
    --22758492(+) CAGCTC/TGGGAG 2 -- us2k10--------
    rs43848861,2
    C,F,H--23711314(+) tcaggT/Cgtttg 2 -- us2k111Minor allele frequency- C:0.19WA NA CSA EA 374
    rs1385700841,2
    --23711357(+) CTCTAA/CAAGAA 2 -- us2k10--------
    rs1174334491,2
    C,F--23711422(+) ACTGAG/AGTGGG 2 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1417594451,2
    --23711448(+) CAGAAA/GCTTGA 2 -- us2k10--------
    rs1158118401,2
    F--23711487(+) GCACTC/GCAGCC 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs57576531,2
    C,F,A,H--23711619(+) gctcaC/Tgcctg 2 -- us2k12Minor allele frequency- T:0.47NA EA 240
    rs57576541,2
    C,F,A,H--23711672(+) aggtcA/Gggagt 2 -- us2k1 tfbs33Minor allele frequency- G:0.33NA CSA 6

    HapMap Linkage Disequilibrium report for TAB1 (39795746 - 39833132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TAB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724254CNV Deletion23290073
    esv2724255CNV Deletion23290073
    nsv3628CNV Insertion18451855
    nsv834199CNV Loss17160897
    nsv915099CNV Loss21882294
    nsv915098CNV Loss21882294
    nsv471200CNV Loss18288195
    nsv834198CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602615    OMIM disorders: --


    Find genes that share disorders with TAB1           About GenesLikeMe

    3 Novoseek inferred disease relationships for TAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 39.2 2 12488458 (1), 18566231 (1)
    tumors 10.1 1 18566231 (1)
    breast cancer 7.5 2 18316610 (2)

    Human Genome Epidemiology (HuGE) Navigator: TAB1 (3 documents)

    Export disorders for TAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAB1 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with TAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PubMed id 8638164)1, 2, 3, 9 Shibuya H.... Matsumoto K. (Science 1996)
    2. TAB1beta (transforming growth factor-beta-activated protein kinase 1- binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PubMed id 12429732)1, 2, 9 Ge B....Han J. (J. Biol. Chem. 2003)
    3. TAK1-binding protein 1 is a pseudophosphatase. (PubMed id 16879102)1, 2, 9 Conner S.H.... Van Aalten D.M.F. (Biochem. J. 2006)
    4. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. (PubMed id 10187861)1, 3, 9 Sakurai H....Sugita T. (J. Biol. Chem. 1999)
    5. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)1, 2, 9 Wang C.... Chen Z.J. (Nature 2001)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    8. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. (PubMed id 10094049)1, 2 Ninomiya-Tsuji J....Matsumoto K. (Nature 1999)
    9. Determinants that control the specific interactions between TAB1 and p38alpha. (PubMed id 16648477)1, 9 Zhou H....Han J. (Mol. Cell. Biol. 2006)
    10. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PubMed id 16845370)2, 9 Thiefes A....Kracht M. (EMBO Rep. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10454 HGNC: 18157 AceView: MAP3K7IP1 Ensembl:ENSG00000100324 euGenes: HUgn10454
    ECgene: TAB1 Kegg: 10454 H-InvDB: TAB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAB1 gene:
    Search GeneIP for patents involving TAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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