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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAB1 Gene

protein-coding   GIFtS: 60
GCID: GC22P039796

TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1

(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting...)
(Previous symbol: MAP3K7IP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 11 2     3'-Tab12
MAP3K7IP11 2 3 5     TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 12
TAK1-Binding Protein 11 2 3     Transforming Growth Factor Beta-Activated Kinase-Binding Protein 12
Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 12 3     TGF-Beta-Activated Kinase 1-Binding Protein 13
Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 11     

External Ids:    HGNC: 181571   Entrez Gene: 104542   Ensembl: ENSG000001003247   OMIM: 6026155   UniProtKB: Q157503   

Export aliases for TAB1 gene to outside databases

Previous GC identifer: GC22P022760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAB1 Gene:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which
is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1,
and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion
of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a
dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta
receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14
(MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways,
which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript
variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAB1 Gene: 
TAB1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1) is a protein-coding gene. Diseases associated with TAB1 include toxoplasmosis, and kawasaki disease, and among its related super-pathways are NOD1/2 Signaling Pathway and Immune response TLR signaling pathways. GO annotations related to this gene include kinase activator activity and catalytic activity.

UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important
role in mammalian embryogenesis

Gene Wiki entry for TAB1 (MAP3K7IP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TAB1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

TAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAB1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039796:  view genomic region     (about GC identifiers)

Start:
39,795,746 bp from pter      End:
39,833,132 bp from pter
Size:
37,387 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750 (See protein sequence)
Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1  
Size: 504 amino acids; 54644 Da
Subunit: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the
TRIKA2 complex composed of MAP3K7, TAB1 and TAB2
Caution: Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost
phosphatase activity
6/7 PDB 3D structures from and Proteopedia for TAB1 (see all 7):
2J4O (3D)        2POM (3D)        2POP (3D)        2YIY (3D)        4AY5 (3D)        4AY6 (3D)    
Secondary accessions: Q2PP09 Q8IZW2
Alternative splicing: 2 isoforms:  Q15750-1   Q15750-2   (Does not bind nor activate MAP3K7/TAK1)

Explore the universe of human proteins at neXtProt for TAB1: NX_Q15750

Explore proteomics data for TAB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15750

  • TAB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006107.1  NP_705717.1  

    ENSEMBL proteins: 
     ENSP00000216160   ENSP00000333049  
    Reactome Protein details: Q15750
    Human Recombinant Protein Products for TAB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TAB1
    OriGene Protein Over-expression Lysate for TAB1
    OriGene MassSpec for TAB1 
    OriGene Custom Protein Services for TAB1
    GenScript Custom Purified and Recombinant Proteins Services for TAB1
    Novus Biologicals TAB1 Proteins
    Novus Biologicals TAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    TAB1 for ontologies           About GeneDecksing



    TAB1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TAB1
    R&D Systems Antibodies for TAB1
    Cell Signaling Technology (CST) Antibodies for TAB1 
    OriGene Antibodies for TAB1
    OriGene Custom Antibody Services for TAB1
    GenScript Custom Superior Antibodies Services for TAB1
    Novus Biologicals TAB1 Antibodies
    Abcam antibodies for TAB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for TAB1
    LSBio Antibodies in human, mouse, rat for TAB1 

    Assay Products for TAB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001932 PP2C-like
     IPR015655 Protein_Pase_2C

    Graphical View of Domain Structure for InterPro Entry Q15750

    ProtoNet protein and cluster: Q15750

    UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
    Similarity: Contains 1 PP2C-like domain


    TAB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAB1_HUMAN, Q15750
    Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important
    role in mammalian embryogenesis

         Genatlas biochemistry entry for TAB1:
    transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP
    signaling through binding with API3 (XIAP)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding IPI10094049
    GO:0008047enzyme activator activity TAS8638164
    GO:0019209kinase activator activity IEA--
         
    TAB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAB1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tab1):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  muscle 
     normal  respiratory system  skeleton 

    TAB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TAB1: Tab1tm1.1Mis Tab1tm1Geny

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAB1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAB1:
    hsa-miR-622 hsa-miR-3118 hsa-miR-134 hsa-miR-516a-3p hsa-miR-516b* hsa-miR-518f* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidTAB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAB1
    Sirion Biotech Customized adenovirus for overexpression of TAB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TAB1 (see all 12)
    OriGene ORF clones in mouse, rat for TAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1
    Sirion Biotech Customized lentivirus for stable overexpression of TAB1 
                         Customized lentivirus expression plasmids for stable overexpression of TAB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAB1
    Search LifeMap BioReagents cell lines for TAB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAB1 About   (see all 38)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Interleukin-1 signaling
    IL1-mediated signaling events0.39
    Interleukin-1 signaling0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for TAB1 (see all 6)
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway
    Translation Regulation activity of EIF4F

    2 R&D Systems Pathways for TAB1
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways


    3 Cell Signaling Technology (CST) Pathways for TAB1
        MAP Kinase Signaling
    TGF-beta/Smad Signaling
    NF-kappaB Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for TAB1 (see all 10)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response TLR signaling pathways
    Bacterial infections in CF airways
    Development TGF-beta receptor signaling

    5/12 BioSystems Pathways for TAB1 (see all 12)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Integrated Breast Cancer Pathway
    TGF-beta Receptor Signaling Pathway
    Toll-like receptor signaling pathway

    5/34        Reactome Pathways for TAB1 (see all 34)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    FCERI mediated NF-kB activation
    IRAK2 mediated activation of TAK1 complex
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    5/10         Kegg Pathways  (Kegg details for TAB1) (see all 10):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    TAB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/201 Interacting proteins for TAB1 (Q157502, 3 ENSP000002161604) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074372, 3, ENSP000004100714MINT-49174 I2D: score=2 STRING: ENSP00000410071
    ENSG00000183311P074372, 3MINT-49174 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49174 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49174 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49174 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IEA--
    GO:0000187activation of MAPK activity TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    TAB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAB1

    3 Novoseek inferred chemical compound relationships for TAB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 99.5 184 17205106 (10), 12429732 (8), 17932218 (7), 17052891 (6) (see all 51)
    tab-2 96.6 20 16845370 (3), 15590691 (3), 14670075 (2), 11518704 (2) (see all 12)
    sb 203580 52.9 1 17932218 (1)

    Search CenterWatch for drugs/clinical trials and news about TAB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAB1 gene (2 alternative transcripts): 
    NM_006116.2  NM_153497.2  

    Unigene Cluster for TAB1:

    TGF-beta activated kinase 1/MAP3K7 binding protein 1
    Hs.507681  [show with all ESTs]
    Unigene Representative Sequence: BC038582
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216160(uc003axr.3 uc003axt.3 uc011aok.2) ENST00000473613
    ENST00000331454(uc003axu.1) ENST00000461775 ENST00000490819 ENST00000473491
    ENST00000488859(uc021wpx.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAB1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TAB1:
    hsa-miR-622 hsa-miR-3118 hsa-miR-134 hsa-miR-516a-3p hsa-miR-516b* hsa-miR-518f* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidTAB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAB1
    Clone
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    OriGene clones in human, mouse for TAB1 (see all 12)
    OriGene ORF clones in mouse, rat for TAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAB1 (NM_153497)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAB1
    Sirion Biotech Customized lentivirus for stable overexpression of TAB1 
                         Customized lentivirus expression plasmids for stable overexpression of TAB1 
    Primer
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    OriGene qPCR primer pairs and template standards for TAB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TAB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB1

    Additional mRNA sequence: 

    AF425640.1 AK291668.1 AK296314.1 AK308903.1 AK312456.1 AK316004.1 BC038582.1 BC050554.1 
    EF036484.1 U49928.1 

    13 DOTS entries:

    DT.416823  DT.100024651  DT.100841680  DT.97779153  DT.100841682  DT.100032803  DT.100841688  DT.100694188 
    DT.120645251  DT.91985224  DT.99966152  DT.100714323  DT.97805216 

    24/230 AceView cDNA sequences (see all 230):

    BQ431917 Z41387 BQ050651 BX380141 H45303 Z43346 BC038582 F02762 
    BQ645086 BX396811 BX328210 NM_006116 AA806471 BQ025572 BX432385 F08391 
    BE018709 NM_153497 AI827837 AW613952 BX358000 BU624204 BX324983 AA253016 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCTTCT
    TAB1 Expression
    About this image


    See TAB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAB1

    SOURCE GeneReport for Unigene cluster: Hs.507681

    UniProtKB/Swiss-Prot: TAB1_HUMAN, Q15750
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including TAB1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for TAB1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TAB1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tab11 , 5 TGF-beta activated kinase 1/MAP3K7 binding protein more1, 5 88.71(n)1
    97.61(a)1
      15 (37.85 cM)5
    665131  NM_025609.21  NP_079885.21 
     801331545 
    chicken
    (Gallus gallus)
    Aves TAB11 TGF-beta activated kinase 1/MAP3K7 binding protein more 80.09(n)
    89.02(a)
      418014  NM_001006240.1  NP_001006240.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAB16
    Uncharacterized protein
    83(a)
    1 ↔ 1
    5(24706847-24726981)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980252 TAB1 75.37(n)    U92031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.167542 Danio rerio TAK1-binding protein 1, mRNA (cDNA clone more 75.47(n)    BC058295.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0029531 AGAP002953-PA 48.34(n)
    40.6(a)
      1273010  XM_311946.4  XP_311946.4 
    worm
    (Caenorhabditis elegans)
    Secernentea tap-16
    Protein TAP-1
    25(a)
    1 ↔ 1
    X(14589636-14591963)


    ENSEMBL Gene Tree for TAB1 (if available)
    TreeFam Gene Tree for TAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAB1 gene
    1 SIMAP similar gene for TAB1 using alignment to 1 protein entry:     TAB1_HUMAN:
    MAP3K7IP1

    TAB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/999 SNPs in TAB1 are shown (see all 999)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899367791,2
    C--22758444(+) ACCTCA/GGCCTC 2 -- us2k10--------
    rs43864221,2
    C,F--22758483(+) CACCGT/CGCCCA 2 -- us2k18Minor allele frequency- C:0.05WA NA CSA EA 134
    rs1825640271,2
    --22758492(+) CAGCTC/TGGGAG 2 -- us2k10--------
    rs43848861,2
    C,F,H--23711314(+) tcaggT/Cgtttg 2 -- us2k111Minor allele frequency- C:0.19WA NA CSA EA 374
    rs1385700841,2
    --23711357(+) CTCTAA/CAAGAA 2 -- us2k10--------
    rs1174334491,2
    C,F--23711422(+) ACTGAG/AGTGGG 2 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1417594451,2
    --23711448(+) CAGAAA/GCTTGA 2 -- us2k10--------
    rs1158118401,2
    F--23711487(+) GCACTC/GCAGCC 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs57576531,2
    C,F,A,H--23711619(+) gctcaC/Tgcctg 2 -- us2k12Minor allele frequency- T:0.47NA EA 240
    rs57576541,2
    C,F,A,H--23711672(+) aggtcA/Gggagt 2 -- us2k1 tfbs33Minor allele frequency- G:0.33NA CSA 6

    HapMap Linkage Disequilibrium report for TAB1 (39795746 - 39833132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TAB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724254CNV Deletion23290073
    esv2724255CNV Deletion23290073
    nsv3628CNV Insertion18451855
    nsv834199CNV Loss17160897
    nsv915099CNV Loss21882294
    nsv915098CNV Loss21882294
    nsv471200CNV Loss18288195
    nsv834198CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602615    OMIM disorders: --

    15 diseases for TAB1:    About MalaCards
    toxoplasmosis    kawasaki disease    primary biliary cirrhosis    leishmaniasis
    kaposi's sarcoma    bronchiolitis    crohn's disease    sarcoma
    ischemia    rheumatoid arthritis    arthritis    breast cancer
    prostate cancer    prostatitis    endotheliitis


    TAB1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 39.2 2 12488458 (1), 18566231 (1)
    tumors 10.1 1 18566231 (1)
    breast cancer 7.5 2 18316610 (2)

    Human Genome Epidemiology (HuGE) Navigator: TAB1 (3 documents)

    Export disorders for TAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAB1 gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with TAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PubMed id 8638164)1, 2, 3, 9 Shibuya H.... Matsumoto K. (1996)
    2. TAB1beta (transforming growth factor-beta-activated protein kinase 1- binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PubMed id 12429732)1, 2, 9 Ge B....Han J. (2003)
    3. TAK1-binding protein 1 is a pseudophosphatase. (PubMed id 16879102)1, 2, 9 Conner S.H....Van Aalten D.M. (2006)
    4. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation . (PubMed id 10187861)1, 3, 9 Sakurai H....Sugita T. (1999)
    5. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)1, 2, 9 Wang C.... Chen Z.J. (2001)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    8. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. (PubMed id 10094049)1, 2 Ninomiya-Tsuji J....Matsumoto K. (1999)
    9. Determinants that control the specific interactions between TAB1 and p38alpha. (PubMed id 16648477)1, 9 Zhou H....Han J. (2006)
    10. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PubMed id 16845370)2, 9 Thiefes A....Kracht M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10454 HGNC: 18157 AceView: MAP3K7IP1 Ensembl:ENSG00000100324 euGenes: HUgn10454
    ECgene: TAB1 Kegg: 10454 H-InvDB: TAB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAB1 gene:
    Search GeneIP for patents involving TAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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