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Aliases for TAB1 Gene

Aliases for TAB1 Gene

  • TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1 2 3 5
  • TAK1-Binding Protein 1 2 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 2 2
  • Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1 3 4
  • MAP3K7IP1 3 4
  • Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1 3
  • TGF-Beta-Activated Kinase 1 And MAP3K7-Binding Protein 1 3
  • TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1 2
  • TGF-Beta-Activated Kinase 1-Binding Protein 1 4
  • 3-Tab1 3

External Ids for TAB1 Gene

Previous HGNC Symbols for TAB1 Gene

  • MAP3K7IP1

Previous GeneCards Identifiers for TAB1 Gene

  • GC22P039796
  • GC22P022760

Summaries for TAB1 Gene

Entrez Gene Summary for TAB1 Gene

  • The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAB1 Gene

TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and Cell adhesion_Plasmin signaling. GO annotations related to this gene include protein complex binding and kinase activator activity.

UniProtKB/Swiss-Prot for TAB1 Gene

  • May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Gene Wiki entry for TAB1 Gene

Additional gene information for TAB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAB1 Gene

Genomics for TAB1 Gene

Regulatory Elements for TAB1 Gene

Enhancers for TAB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H039518 2 FANTOM5 Ensembl ENCODE dbSUPER 40.8 +124.6 124643 12.3 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZFP41 SSRP1 ENSG00000272834 TAB1 ENSG00000230912 ATF4 ENSG00000228274 RPL3 CBY1 CBX6 SNORD83B CBX7
GH22H038768 1.5 Ensembl ENCODE dbSUPER 38.8 -630.7 -630741 0.4 ZNF493 ZFP64 GLIS2 ZNF143 ZNF202 ZC3H11A TSHZ1 REST MIER2 ZNF623 DDX17 CSNK1E EIF3L TAB1 ENSG00000228274 CBY1 SNORD83B ENSG00000230912 PLA2G6 RPL3
GH22H038691 1.4 ENCODE dbSUPER 32.7 -703.1 -703122 10.9 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBY1 ENSG00000228274 FAM227A TAB1 ENSG00000230912 DDX17 PLA2G6 CBX7 CBX6 NPTXR
GH22H039308 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -89.4 -89408 4.3 HDGF PKNOX1 MLX ARNT ZFP64 SIN3A FEZF1 ZNF2 ZNF143 FOS DDX17 RPL3 SYNGR1 APOBEC3A ENSG00000230149 SNORD83B ENSG00000273076 ENSG00000272669 ENSG00000225450 TAB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAB1 on UCSC Golden Path with GeneCards custom track

Promoters for TAB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146331 -40 1400 HDGF ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF207 ZNF143

Genomic Locations for TAB1 Gene

Genomic Locations for TAB1 Gene
37,387 bases
Plus strand

Genomic View for TAB1 Gene

Genes around TAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAB1 Gene

Proteins for TAB1 Gene

  • Protein details for TAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q2PP09
    • Q8IZW2

    Protein attributes for TAB1 Gene

    504 amino acids
    Molecular mass:
    54644 Da
    Quaternary structure:
    • Interacts with XIAP and BIRC7 (PubMed:17560374, PubMed:11865055). Interacts with TRAF6 and MAP3K7; during IL-1 signaling (PubMed:8638164, PubMed:10094049, PubMed:11323434). Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2 (PubMed:11460167).

    Three dimensional structures from OCA and Proteopedia for TAB1 Gene

    Alternative splice isoforms for TAB1 Gene


neXtProt entry for TAB1 Gene

Post-translational modifications for TAB1 Gene

  • Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
  • Ubiquitination at posLast=150150 and posLast=264264
  • Modification sites at PhosphoSitePlus

Other Protein References for TAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAB1 Gene

Domains & Families for TAB1 Gene

Gene Families for TAB1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TAB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAB1: view

No data available for UniProtKB/Swiss-Prot for TAB1 Gene

Function for TAB1 Gene

Molecular function for TAB1 Gene

GENATLAS Biochemistry:
transforming growth factor beta activated kinase (TAK)-binding protein 1,widely expressed,involved in the BMP signaling through binding with API3 (XIAP)
UniProtKB/Swiss-Prot Function:
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Phenotypes From GWAS Catalog for TAB1 Gene

Gene Ontology (GO) - Molecular Function for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0005515 protein binding IPI 10094049
GO:0008047 enzyme activator activity TAS 8638164
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with TAB1: view
genes like me logo Genes that share phenotypes with TAB1: view

Animal Models for TAB1 Gene

MGI Knock Outs for TAB1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAB1 Gene

Localization for TAB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAB1 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 4
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0016607 nuclear speck IDA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with TAB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAB1 Gene

Pathways & Interactions for TAB1 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Toll-Like receptor Signaling Pathways
3 IL-1 signaling pathway
4 Bacterial infections in CF airways
5 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with TAB1: view

SIGNOR curated interactions for TAB1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0001701 in utero embryonic development IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TAB1: view

Drugs & Compounds for TAB1 Gene

(2) Drugs for TAB1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra Target 35

(2) Additional Compounds for TAB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAB1: view

Transcripts for TAB1 Gene

Unigene Clusters for TAB1 Gene

TGF-beta activated kinase 1/MAP3K7 binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAB1 Gene

No ASD Table

Relevant External Links for TAB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAB1 Gene

Protein differential expression in normal tissues from HIPED for TAB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Fetal Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAB1 Gene

Protein tissue co-expression partners for TAB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAB1 Gene:


SOURCE GeneReport for Unigene cluster for TAB1 Gene:


mRNA Expression by UniProt/SwissProt for TAB1 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAB1 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TAB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAB1 Gene

Orthologs for TAB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAB1 33 34
  • 99.53 (n)
(Canis familiaris)
Mammalia TAB1 33 34
  • 90.03 (n)
(Mus musculus)
Mammalia Tab1 33 16 34
  • 88.71 (n)
(Rattus norvegicus)
Mammalia Tab1 33
  • 87.45 (n)
(Bos Taurus)
Mammalia MAP3K7IP1 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TAB1 34
  • 81 (a)
(Monodelphis domestica)
Mammalia TAB1 34
  • 68 (a)
(Gallus gallus)
Aves TAB1 33 34
  • 80.09 (n)
(Anolis carolinensis)
Reptilia TAB1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tab1 33
  • 71.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398025 33
(Danio rerio)
Actinopterygii tab1 33 34
  • 66 (n)
Dr.16754 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002953 33
  • 49.07 (n)
(Caenorhabditis elegans)
Secernentea tap-1 34
  • 26 (a)
Species where no ortholog for TAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAB1 Gene

Gene Tree for TAB1 (if available)
Gene Tree for TAB1 (if available)

Paralogs for TAB1 Gene

(1) SIMAP similar genes for TAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAB1: view

No data available for Paralogs for TAB1 Gene

Variants for TAB1 Gene

Sequence variations from dbSNP and Humsavar for TAB1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000049465 -- 39,433,917(+) TCCTC(C/T)ATGGG intron-variant
rs1000105901 -- 39,425,909(+) GCCCT(A/G)TTGGC intron-variant
rs1000162606 -- 39,434,053(+) CAGGG(A/G)GGAAG intron-variant
rs1000322641 -- 39,433,737(+) GCAGC(C/T)GGGCC intron-variant
rs1000337588 -- 39,423,216(+) AACTC(C/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAB1 Gene

Variant ID Type Subtype PubMed ID
esv2724254 CNV deletion 23290073
esv2724255 CNV deletion 23290073
esv3568393 CNV loss 25503493
esv3647764 CNV loss 21293372
nsv3628 CNV insertion 18451855
nsv471200 CNV loss 18288195
nsv834198 CNV loss 17160897
nsv834199 CNV loss 17160897

Variation tolerance for TAB1 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAB1 Gene

Disorders for TAB1 Gene

Relevant External Links for TAB1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAB1 Gene

Publications for TAB1 Gene

  1. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. (PMID: 8638164) Shibuya H … Matsumoto K (Science (New York, N.Y.) 1996) 2 3 4 22 60
  2. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. (PMID: 16845370) Thiefes A … Kracht M (EMBO reports 2006) 3 4 22 60
  3. TAK1-binding protein 1 is a pseudophosphatase. (PMID: 16879102) Conner SH … Van Aalten DM (The Biochemical journal 2006) 3 4 22 60
  4. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. (PMID: 12429732) Ge B … Han J (The Journal of biological chemistry 2003) 3 4 22 60
  5. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PMID: 11460167) Wang C … Chen ZJ (Nature 2001) 3 4 22 60

Products for TAB1 Gene

Sources for TAB1 Gene

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