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TAAR9 Gene

protein-coding GIFtS: 50

GC06P132903

trace amine associated receptor 9
(Previous name: trace amine receptor 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TRAR3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TA3 ^¹, ², ³
TAR3 ^¹, ², ³
TRAR3 ^², ³
TaR-3 ^³

Descriptions
Trace amine receptor 3 ^¹, ², ³
trace amine associated receptor 9 ^²

External Ids
HGNC: 20977¹
Entrez Gene: 134860²
UniProtKB: Q96RI9³
Ensembl: ENSG00000218138⁷

Search outside databases for aliases for TAAR9 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAAR9:

TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs).

GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G

proteins.[supplied by OMIM]

UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9

Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines

present in very low levels in mammalian tissues. Although some trace amines have clearly defined

roles as neurotransmitters in invertebrates, the extent to which they function as true

neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved

in a variety of physiological functions that have yet to be fully understood

Gene Wiki entry for TAAR9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAAR9 gene

Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.1

TAAR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P132903: (about GC identifiers)

Start:	132,901,120 bp from pter
End:	132,902,168 bp from pter
Size:	1,049 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9 (See protein sequence)

Recommended Name: Trace amine-associated receptor 9

Size: 348 amino acids; 39016 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

REFSEQ proteins: NP_778227.3
Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TA3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for TAAR9:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TAAR9
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TA3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for TAAR9

Assays for TAAR9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96RI9

ProtoNet protein and cluster: Q96RI9

UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175057

Applied Biosystems Silencer® siRNAs for TAAR9

Sigma-Aldrich siRNA and siRNA Panels for TAAR9

Sigma-Aldrich shRNA Panels and shRNA for TAAR9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_175057
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175057
untagged cDNA clones in CMV expression vector (see all 2): NM_175057

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_175057

UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9

Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines

present in very low levels in mammalian tissues. Although some trace amines have clearly defined

roles as neurotransmitters in invertebrates, the extent to which they function as true

neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved

in a variety of physiological functions that have yet to be fully understood

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	15718104

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	15718104

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAAR9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR9)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175057

Sigma-Aldrich siRNA and siRNA Panels for TAAR9

Sigma-Aldrich shRNA Panels and shRNA for TAAR9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_175057

REFSEQ mRNAs for TAAR9 gene:

NM_175057.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_175057

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175057
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175057
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_175057

Additional cDNA sequence:

AY183469.1 BC069083.1

1 DOTS entry:

DT.102819967

5 AceView cDNA sequences:

NM_175057 BC069083 AY183469 CN832506 CN832330

highest scoring ESTs for TAAR9:

AY183469 BC069083 CN832330 CN832506 NM_175057 CO935350 CO935358 CO957769 CO957783

Unigene Cluster for TAAR9:

Trace amine associated receptor 9

Hs.434116 [show with all ESTs]

Unigene Representative Sequence: NM_175057

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000407605

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAAR9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAAR9

¹ / ²

1 probe-set matching TAAR9 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1553066_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTTTATAT

SOURCE GeneReport for Unigene cluster: Hs.434116

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAAR9 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	TAAR9¹	--	trace amine associated receptor 9	87.55(n) 90.8(a)	785334 XM_001253398.1 XP_001253399.1
rat (Rattus norvegicus)	Taar9¹	--	trace amine-associated receptor 9	83.63(n) 87.72(a)	319107 NM_175602.1 NP_783192.1
mouse (Mus musculus)	Taar9^{1, 5}	10⁵	trace amine-associated receptor 9^{1, 5}	83.91(n)¹ 87.79(a)¹	503558¹ NM_001010831.1¹ NP_001010831.1¹ AY255559⁵ AY702340⁵ (see all 7)

About this table Species with no ortholog for TAAR9

ENSEMBL Gene Tree for TAAR9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/25 NCBI SNPs in TAAR9 are shown (see all 25 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 48)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2842898^1,2	A,C,F,H,O	132902215(-)	`TTGCAC/GTTGAC`	1	--	ng3¹		7	NA EU EA WA	552
	rs2842899^1,2	A,C,F,H	132901302(-)	`TTGTTT/AGAAGT`	1	X/K	non¹		16	EA NA EU WA	1416
	rs6930707^1,2	A,C,F,H	132902268(+)	`CAAGTT/GGTAGG`	1	--	ng3¹		4	EU EA WA	412
	rs2842897^1,2	A,C,F,H	132902406(-)	`AAGTAG/AGGAAC`	1	--	ng3¹		4	EU EA WA	416
	rs17061372^1,2	C,F,H	132899844(+)	`CTTATA/GAAGAA`	1	--	ng5¹		11	NA EU EA WA	976
	rs17061369^1,2	C,F,H	132899380(+)	`AAATAG/ACATTC`	1	--	ng5¹		11	NA EU EA WA	966
	rs9389004^1,2	C,F,H	132901953(+)	`TTGATG/ACAGTG`	1	T/A	mis¹		8	EU EA WA	836
	rs12527371^1,2	C,F,H	132899252(+)	`CTCTAC/TGAGAC`	1	--	ng5¹		11	EU EA WA NA	980
	rs17061384^1,2	F,H	132902236(+)	`TTGGAC/TATAGA`	1	--	ng3¹		8	NA EU EA WA	632
	rs6913154^1,2	F,H	132899697(+)	`ATTGAT/CTTAAA`	1	--	ng5¹		4	EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for TAAR9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608282

Human Gene Mutation Database: TAAR9

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for TAAR9 gene:

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)^{2, 3} Lindemann L....Hoener M.C. (2005)
Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)^{3, 4} Borowsky B.... Gerald C. (2001)
A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)³ Liberles S.D. and Buck L.B. (2006)
Discovery of a null mutation in a human trace amine receptor gene. (PubMed id 14559210)³ Vanti W.B....O'Dowd B.F. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. (PubMed id 19325074)¹ Maguire J.J....Davenport A.P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 134860	HGNC: 20977	AceView: TRAR3	Ensembl:ENSG00000218138	euGenes: HUgn134860
ECgene: TAAR9	H-InvDB: TAAR9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TAAR9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAAR9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAAR9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAAR9		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TAAR9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (TA3)
	Antibodies (TA3)

Search OriGene for TAAR9

Search Tocris compounds for TAAR9

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAAR9

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TAAR9 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for TAAR9

Summaries
for TAAR9

Genomic Location
for TAAR9

Proteins
for TAAR9

Protein Domains/
Families
for TAAR9

Gene Function
for TAAR9

Pathways & Interactions
for TAAR9

Drugs & Compounds
for TAAR9

Transcripts
for TAAR9

Expression
for TAAR9

Orthologs
for TAAR9

Paralogs
for TAAR9

SNPs/Variants
for TAAR9

Disorders & Mutations
for TAAR9

Medical News
for TAAR9

Publications
for TAAR9

Search for TAAR9

Genome Databases showing TAAR9

Other Databases showing TAAR9

Specialized Databases showing TAAR9

Licensable Technologies
for TAAR9

Services
for TAAR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAAR9 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor TAAR9

Summariesfor TAAR9

Genomic Locationfor TAAR9

Proteinsfor TAAR9

Protein Domains/Familiesfor TAAR9

Gene Functionfor TAAR9

Pathways & Interactionsfor TAAR9

Drugs & Compoundsfor TAAR9

Transcriptsfor TAAR9

Expression for TAAR9

Orthologsfor TAAR9

Paralogsfor TAAR9

SNPs/Variantsfor TAAR9

Disorders & Mutationsfor TAAR9

Medical Newsfor TAAR9

Publicationsfor TAAR9

Search for TAAR9

Genome Databases showing TAAR9

Other Databases showing TAAR9

Specialized Databases showing TAAR9

Licensable Technologiesfor TAAR9

Servicesfor TAAR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAAR9

Summaries
for TAAR9

Genomic Location
for TAAR9

Proteins
for TAAR9

Protein Domains/
Families
for TAAR9

Gene Function
for TAAR9

Pathways & Interactions
for TAAR9

Drugs & Compounds
for TAAR9

Transcripts
for TAAR9

Expression
for TAAR9

Orthologs
for TAAR9

Paralogs
for TAAR9

SNPs/Variants
for TAAR9

Disorders & Mutations
for TAAR9

Medical News
for TAAR9

Publications
for TAAR9

Licensable Technologies
for TAAR9

Services
for TAAR9