TAAR9 Gene
protein-coding GIFtS: 48
GCID: GC06P132903
|
|
trace amine associated receptor 9 (gene/pseudogene)(Previous names: trace amine receptor 3, trace amine associated receptor...)
(Previous symbol: TRAR3)
| |
Aliases
for TAAR9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trace Amine Associated Receptor 9 (Gene/Pseudogene)1 2 | | Trace Amine Associated Receptor 91 | | TA31 2 3 5 | | TAR92 | | TAR31 2 3 5 | | Trace Amine-Associated Receptor 92 | | Trace Amine Receptor 31 2 3 | | TaR-33 | | TRAR31 2 3 | | TaR-93 | | Trace Amine Receptor 92 3 | | |
Export aliases for TAAR9 gene to outside databasesPrevious GC identifer: GC06P130434 |
Summaries
for TAAR9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAAR9:
TAAR9 is a member of a large family of rhodopsin G protein-coupled receptors (GPCRs, or GPRs). GPCRs contain 7transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.(supplied by OMIM, Jul2005)
UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Gene Wiki entry for TAAR9
|
Genomic Views
for TAAR9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAAR9 gene promoter:
AML1a Egr-1 FOXO3 FOXO3b Egr-2 PPAR-gamma1 FOXO3a FOXO1a PPAR-gamma2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAAR9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.1TAAR9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P132903: view genomic region
(about GC identifiers)
Start:
|
132,859,427 bp from pter |
End:
|
132,860,475 bp from pter |
Size:
|
1,049 bases |
Orientation:
|
plus strand |
|
Proteins
for TAAR9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9 (See
protein sequence)Recommended Name: Trace amine-associated receptor 9 Size: 348 amino acids; 39016 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for TAAR9: NX_Q96RI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RI9
TAAR9 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_778227.3
ENSEMBL proteins: ENSP00000424607 Reactome Protein details: Q96RI9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TAAR9 for ontologies About GeneDecksing
TAAR9 Antibody Products:
Assay Products for TAAR9: |
Protein
Domains /
Families
for TAAR9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAAR9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RI9ProtoNet protein and cluster: Q96RI9 UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TAAR9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAAR9_HUMAN, Q96RI9Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAAR9 (NM_175057) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR9 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 15718104 |
TAAR9 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TAAR9:
|
Pathways & Interactions
for TAAR9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Monoamine GPCRs | | | 4 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for TAAR9 (see all 7)
1 
Kegg Pathway (Kegg details for TAAR9):
TAAR9 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAAR9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 15718104 |
TAAR9 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAAR9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAAR9
Search CenterWatch for drugs/clinical trials and news about TAAR9
|
Transcripts
for TAAR9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAAR9 gene: NM_175057.3 Unigene Cluster for TAAR9: Trace amine associated receptor 9 (gene/pseudogene) Hs.434116 [show with all ESTs]Unigene Representative Sequence: NM_1750571 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000434551
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAAR9 (NM_175057) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR9 |
Additional cDNA sequence: AY183469.1 BC069083.1 1 DOTS entry: DT.102819967 5 AceView cDNA sequences: NM_175057 BC069083 AY183469 CN832506 CN832330
GeneLoc Exon Structure
|
Expression
for TAAR9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAAR9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTTATAT
About this image
Genevestigator expression for TAAR9
SOURCE GeneReport for Unigene cluster: Hs.434116
SABiosciences Expression via Pathway-Focused PCR Array including TAAR9:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAAR9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR9 |
Orthologs
for TAAR9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for TAAR9 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for TAAR9 (if available)
TreeFam Gene Tree for TAAR9 (if available) |
Paralogs
for TAAR9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TAAR9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAAR9 (132859427 - 132860475 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAAR9: --
Human Gene Mutation Database (HGMD): TAAR9
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR9 |
|
Disorders
/ Diseases
for TAAR9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAAR9 for disorders About GeneDecksing
OMIM gene information: 608282
OMIM disorders: --
1  disease for TAAR9: About MalaCardsadhd
Human Genome Epidemiology (HuGE) Navigator: TAAR9 (1 document)
Export disorders for TAAR9 gene to outside databases
|
Publications
for TAAR9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAAR9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAAR9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 3 Lindemann L....Hoener M.C. (2005)
- Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)1, 2 Borowsky B.... Gerald C. (2001)
- Correlation of a set of gene variants, life events an d personality features on adult ADHD severity. (PubMed id 20006992)1 MA1ller D.J....Kennedy J.L. (2010)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)1 Liberles S.D. and Buck L.B. (2006)
- Discovery of a null mutation in a human trace amine receptor gene. (PubMed id 14559210)1 Vanti W.B....O'Dowd B.F. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. (PubMed id 19325074)9 Maguire J.J....Davenport A.P. (2009)
|
External Searches for TAAR9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAAR9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAAR9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAAR9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAAR9 gene:
Search GeneIP for patents involving TAAR9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAAR9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAAR9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAAR9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR9 | | | OriGene Protein Over-expression Lysate for TAAR9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAAR9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAAR9 | | OriGene Custom Protein Services for TAAR9 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAAR9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAAR9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR9 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TAAR9 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TAAR9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR9 |
|  |  |  | | | | ThermoFisher Antibodies for TAAR9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR9 |
|
|
|
|
