Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAAR8 Gene

Aliases for TAAR8 Gene

  • Trace Amine Associated Receptor 8 2 3
  • Trace Amine Receptor 5 2 3 4
  • GPR102 3 4 6
  • TA5 3 4 6
  • G-Protein Coupled Receptor 102 3 4
  • Trace Amine Receptor 8 3 4
  • TRAR5 3 4
  • TaR-5 3 4
  • TaR-8 3 4
  • TAR5 3 4
  • Trace Amine-Associated Receptor 8 3
  • G Protein-Coupled Receptor 102 3

External Ids for TAAR8 Gene

Previous HGNC Symbols for TAAR8 Gene

  • GPR102
  • TRAR5

Previous GeneCards Identifiers for TAAR8 Gene

  • GC06P132916
  • GC06P130448

Summaries for TAAR8 Gene

GeneCards Summary for TAAR8 Gene

TAAR8 (Trace Amine Associated Receptor 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for TAAR8 Gene

  • Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood

Gene Wiki entry for TAAR8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR8 Gene

Genomics for TAAR8 Gene

Regulatory Elements for TAAR8 Gene

Genomic Location for TAAR8 Gene

Start:
132,552,693 bp from pter
End:
132,553,721 bp from pter
Size:
1,029 bases
Orientation:
Plus strand

Genomic View for TAAR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAAR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR8 Gene

Proteins for TAAR8 Gene

  • Protein details for TAAR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969N4-TAAR8_HUMAN
    Recommended name:
    Trace amine-associated receptor 8
    Protein Accession:
    Q969N4
    Secondary Accessions:
    • Q5VUQ0

    Protein attributes for TAAR8 Gene

    Size:
    342 amino acids
    Molecular mass:
    38029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR8 Gene

Proteomics data for TAAR8 Gene at MOPED

Post-translational modifications for TAAR8 Gene

  • Glycosylation at Asn4 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR8 Gene

Domains for TAAR8 Gene

Gene Families for TAAR8 Gene

HGNC:
  • TAAR :GPCR / Class A : Trace amine associated receptors
IUPHAR :

Protein Domains for TAAR8 Gene

Suggested Antigen Peptide Sequences for TAAR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969N4

UniProtKB/Swiss-Prot:

TAAR8_HUMAN :
  • Q969N4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR8: view

Function for TAAR8 Gene

Molecular function for TAAR8 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood

Gene Ontology (GO) - Molecular Function for TAAR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 15718104
genes like me logo Genes that share ontologies with TAAR8: view

Phenotypes for TAAR8 Gene

GenomeRNAi human phenotypes for TAAR8:
genes like me logo Genes that share phenotypes with TAAR8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAAR8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAAR8 Gene

Localization for TAAR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAAR8 Gene COMPARTMENTS Subcellular localization image for TAAR8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAAR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 15718104
genes like me logo Genes that share ontologies with TAAR8: view

Pathways for TAAR8 Gene

genes like me logo Genes that share pathways with TAAR8: view

Pathways by source for TAAR8 Gene

Interacting Proteins for TAAR8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275200%0d%0a9606.ENSP00000362931%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000275200 for TAAR8 Gene via STRING

Gene Ontology (GO) - Biological Process for TAAR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 15718104
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TAAR8: view

Transcripts for TAAR8 Gene

mRNA/cDNA for TAAR8 Gene

(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR8 Gene

Trace amine associated receptor 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAAR8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR8 Gene

No ASD Table

Relevant External Links for TAAR8 Gene

GeneLoc Exon Structure for
TAAR8
ECgene alternative splicing isoforms for
TAAR8

Expression for TAAR8 Gene

mRNA expression in normal human tissues for TAAR8 Gene

SOURCE GeneReport for Unigene cluster for TAAR8 Gene Hs.350571

mRNA Expression by UniProt/SwissProt for TAAR8 Gene

Q969N4-TAAR8_HUMAN
Tissue specificity: Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested.
genes like me logo Genes that share expressions with TAAR8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for TAAR8 Gene

Orthologs for TAAR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
TAAR8 35
  • 85.59 (n)
  • 80.59 (a)
mouse
(Mus musculus)
Mammalia Taar8a 16
Taar8a 36
  • 78 (a)
OneToMany
Taar8b 35
  • 81.77 (n)
  • 80.7 (a)
Taar8b 36
  • 80 (a)
OneToMany
Taar8c 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii taar13b 36
  • 39 (a)
ManyToMany
Species with no ortholog for TAAR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR8 Gene

ENSEMBL:
Gene Tree for TAAR8 (if available)
TreeFam:
Gene Tree for TAAR8 (if available)

Paralogs for TAAR8 Gene

Paralogs for TAAR8 Gene

Selected SIMAP similar genes for TAAR8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAAR8: view

Variants for TAAR8 Gene

Sequence variations from dbSNP and Humsavar for TAAR8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2788945 -- 132,554,144(-) CCTGG(A/G)CAACA downstream-variant-500B
rs2788946 -- 132,554,096(-) AAAGA(A/G)AAGAA downstream-variant-500B
rs6912620 -- 132,552,803(+) ACGGC(A/G)TTTAG synonymous-codon, reference
rs8192626 - 132,553,150(+) CATCA(A/G)CGTGT missense, reference
rs8192627 - 132,553,675(+) TGGAG(A/C)TGTTT reference, missense

Relevant External Links for TAAR8 Gene

HapMap Linkage Disequilibrium report
TAAR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAAR8 Gene

Disorders for TAAR8 Gene

No disorders were found for TAAR8 Gene.

No data available for UniProtKB/Swiss-Prot for TAAR8 Gene

Publications for TAAR8 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4
  2. Trace amines: identification of a family of mammalian G protein- coupled receptors. (PMID: 11459929) Borowsky B. … Gerald C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3

Products for TAAR8 Gene

Sources for TAAR8 Gene

Back to Top

Content