TAAR8 Gene
protein-coding GIFtS: 50
GCID: GC06P132916
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|
trace amine associated receptor 8(Previous name: trace amine receptor 5 )
(Previous symbols: GPR102, TRAR5)
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Aliases
for TAAR8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trace Amine Associated Receptor 81 2 | | Trace Amine Receptor 82 3 | | GPR1021 2 3 5 | | TaR-52 3 | | TA51 2 3 5 | | TaR-82 3 | | Trace Amine Receptor 51 2 3 | | G-Protein Coupled Receptor 1022 3 | | TAR51 2 3 | | G Protein-Coupled Receptor 1022 | | TRAR51 2 3 | | Trace Amine-Associated Receptor 82 |
Export aliases for TAAR8 gene to outside databasesPrevious GC identifer: GC06P130448 |
Summaries
for TAAR8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Gene Wiki entry for TAAR8
|
Genomic Views
for TAAR8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAAR8 gene promoter:
AML1a Egr-1 FOXO3 C/EBPalpha FOXO3b Egr-2 CHOP-10 FOXO3a FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAAR8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2TAAR8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P132916: view genomic region
(about GC identifiers)
Start:
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132,873,832 bp from pter |
End:
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132,874,860 bp from pter |
Size:
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1,029 bases |
Orientation:
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plus strand |
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Proteins
for TAAR8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4 (See
protein sequence)Recommended Name: Trace amine-associated receptor 8 Size: 342 amino acids; 38029 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5VUQ0Explore the universe of human proteins at neXtProt for TAAR8: NX_Q969N4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969N4
TAAR8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444508.1
ENSEMBL proteins: ENSP00000275200 Reactome Protein details: Q969N4
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TAAR8 for ontologies About GeneDecksing
TAAR8 Antibody Products:
Assay Products for TAAR8: |
Protein
Domains /
Families
for TAAR8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAAR8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969N4ProtoNet protein and cluster: Q969N4 UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TAAR8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TAAR8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 15718104 |
TAAR8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TAAR8:
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Pathways & Interactions
for TAAR8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Monoamine GPCRs | | | 4 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for TAAR8 (see all 7)
1 
Kegg Pathway (Kegg details for TAAR8):
TAAR8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAAR8
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 15718104 |
TAAR8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAAR8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAAR8
Search CenterWatch for drugs/clinical trials and news about TAAR8
|
Transcripts
for TAAR8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAAR8 gene: NM_053278.1 Unigene Cluster for TAAR8: Trace amine associated receptor 8 Hs.350571 [show with all ESTs]Unigene Representative Sequence: AY1834681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000275200(uc011ecj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAAR8 (NM_053278) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR8 |
Additional cDNA sequence: AY183468.1 BC069166.1 1 DOTS entry: DT.99937748 3 AceView cDNA sequences: NM_053278 AY183468 BC069166
GeneLoc Exon Structure
|
Expression
for TAAR8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAAR8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCTTTGA
About this image
See TAAR8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAAR8
SOURCE GeneReport for Unigene cluster: Hs.350571
UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4Tissue specificity: Expressed in kidney and amygdala. Not expressed in other tissues or brain regions tested
SABiosciences Custom PCR Arrays for TAAR8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAAR8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR8 |
Orthologs
for TAAR8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAAR8 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for TAAR8 (if available)
TreeFam Gene Tree for TAAR8 (if available) |
Paralogs
for TAAR8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAAR8 gene
- TAAR62 HTR2A2 HTR62 TAAR22 ADRB12 HRH22 HTR2B2 DRD12
- HTR2C2 TAAR12 ADRB22 HTR42 DRD52 ADRB32 TAAR52
11 SIMAP similar genes for TAAR8 using alignment to 1 protein entry: TAAR8_HUMAN:TAAR6 TAAR9 TAAR5 TAAR1 TAAR2 TAAR3
ADRB2 HTR4 HTR4B HRH2 DRD1
TAAR8 for paralogs About GeneDecksing
|
Genomic Variants
for TAAR8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAAR8 (132873832 - 132874860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAAR8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR8 |
|
Disorders
/ Diseases
for TAAR8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAAR8 for disorders About GeneDecksing
OMIM gene information: 606927
OMIM disorders: --
4  diseases for TAAR8: About MalaCardsneonatal jaundice pleuropneumonia glomerulonephritis jaundice
1 disease from the University of Copenhagen DISEASES database for TAAR8:Neonatal jaundice Export disorders for TAAR8 gene to outside databases
|
Publications
for TAAR8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAAR8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAAR8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K....O'Dowd B.F. (2001)
- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 3 Lindemann L....Hoener M.C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)1, 2 Borowsky B.... Gerald C. (2001)
- Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. (PubMed id 21885028)2 Parry D.A.... Sheridan E.G. (2011)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)1 Liberles S.D. and Buck L.B. (2006)
- Receptors of mammalian trace amines. (PubMed id 16584120)1 Lewin A.H. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TAAR8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TAAR8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAAR8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAAR8 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TAAR8 gene:
Search GeneIP for patents involving TAAR8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAAR8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAAR8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAAR8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAAR8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAAR8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAAR8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR8 |
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 | | | TAAR8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR8 |
|  |  |  | | | | ThermoFisher Antibodies for TAAR8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR8 |
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