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TAAR8 Gene

protein-coding GIFtS: 50

GC06P132916

trace amine associated receptor 8
(Previous name: trace amine receptor 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: GPR102, TRAR5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GPR102 ^², ³
OTTHUMP00000017226 ^²
TA5 ^¹, ², ³
TAR5 ^¹, ², ³
TRAR5 ^², ³
TaR-5 ^³

Descriptions
G protein-coupled receptor 102 ^²
G-protein coupled receptor 102 ^³
Trace amine receptor 5 ^¹, ², ³
trace amine associated receptor 8 ^²

External Ids
HGNC: 14964¹
Entrez Gene: 83551²
UniProtKB: Q969N4³
Ensembl: ENSG00000146385⁷

Search outside databases for aliases for TAAR8 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAAR8:

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce

extracellular signals through heterotrimeric G proteins.[supplied by OMIM]

UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4

Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines

present in very low levels in mammalian tissues. Although some trace amines have clearly defined

roles as neurotransmitters in invertebrates, the extent to which they function as true

neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved

in a variety of physiological functions that have yet to be fully understood

Gene Wiki entry for TAAR8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAAR8 gene

Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2

TAAR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P132916: (about GC identifiers)

Start:	132,915,525 bp from pter
End:	132,916,553 bp from pter
Size:	1,029 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4 (See protein sequence)

Recommended Name: Trace amine-associated receptor 8

Size: 342 amino acids; 38029 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q5VUQ0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_444508.1

ENSEMBL proteins:

ENSP00000275200

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GPCR GPR102)
	Human Recombinant Proteins from Abnova (TAAR8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for TAAR8:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TAAR8
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GPCR GPR102), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for TAAR8

Assays for TAAR8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q969N4

ProtoNet protein and cluster: Q969N4

UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053278

Applied Biosystems Silencer® siRNAs for TAAR8

Sigma-Aldrich siRNA and siRNA Panels for TAAR8

Sigma-Aldrich shRNA Panels and shRNA for TAAR8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TAAR8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_053278
Myc/DDK tagged cDNA clone in CMV expression vector: NM_053278
untagged cDNA clone in CMV expression vector: NM_053278

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_053278

UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4

Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines

present in very low levels in mammalian tissues. Although some trace amines have clearly defined

roles as neurotransmitters in invertebrates, the extent to which they function as true

neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved

in a variety of physiological functions that have yet to be fully understood

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	15718104

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Interacting proteins for TAAR8 (ENSP00000275200³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAAR2	ENSP00000356908³	STRING (score=.909)
TAAR1	ENSP00000275216³	STRING (score=.905)
TAAR5	ENSP00000258034³	STRING (score=.904)
TAAR6	ENSP00000275198³	STRING (score=.902)
TBP	ENSP00000230354³	STRING (score=.875)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	15718104

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAAR8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_053278

Sigma-Aldrich siRNA and siRNA Panels for TAAR8

Sigma-Aldrich shRNA Panels and shRNA for TAAR8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_053278

REFSEQ mRNAs for TAAR8 gene:

NM_053278.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_053278

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_053278
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_053278
                                 untagged cDNA clone in CMV expression vector: NM_053278

Additional cDNA sequence:

AY183468.1 BC069166.1

1 DOTS entry:

DT.99937748

3 AceView cDNA sequences:

AY183468 BC069166 NM_053278

highest scoring ESTs for TAAR8:

AY183468 BC069166 NM_053278 CO920393 CO920489 CO959383 CO959384

Unigene Cluster for TAAR8:

Trace amine associated receptor 8

Hs.350571 [show with all ESTs]

Unigene Representative Sequence: AY183468

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000275200

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAAR8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAAR8

¹ / ²

1 probe-set matching TAAR8 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1553552_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATCCTTTGA

SOURCE GeneReport for Unigene cluster: Hs.350571
UniProtKB/Swiss-Prot: TAAR8_HUMAN, Q969N4
Tissue specificity: Expressed in kidney and amygdala. Not expressed in other tissues or brain
regions tested

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAAR8 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	LOC782768¹	--	similar to trace amine associated receptor 8	85.38(n) 81.6(a)	782768 XM_001251414.1 XP_001251415.1
rat (Rattus norvegicus)	Taar8a¹	--	trace amine-associated receptor 8a	81.09(n) 80.12(a)	319104 NM_175599.1 NP_783189.1
mouse (Mus musculus)	Taar8b^{1, 5}	10⁵	trace amine-associated receptor 8B^{1, 5}	82.16(n)¹ 80.99(a)¹	382348¹ NM_001010837.1¹ NP_001010837.1¹ AY702338⁵ BC139105⁵ (see all 6)

About this table Species with no ortholog for TAAR8

ENSEMBL Gene Tree for TAAR8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TAAR8 gene

TAAR6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/16 NCBI SNPs in TAAR8 are shown (see all 16 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9375895^1,2	A,C,F,H	132913733(+)	`ATCTCG/ACTTCT`	1	--	ng5¹		8		EU EA WA	836
	rs11965773^1,2	C,F,H	132914051(+)	`tgttgT/Ctaagt`	1	--	ng5¹		4		EU EA WA	420
	rs8192627^1,2	C,F,H	132916507(+)	`TGGAGA/CTGTTT`	1	D/A	mis¹		8		EU EA WA	838
--	rs8192626^1,2	C,F,H	132915982(+)	`CATCAG/ACGTGT`	1	N/S	mis¹		4		EU EA WA	406
	rs9402423^1,2	F,H	132916812(+)	`CACTTG/ATTTTT`	1	--	ng3¹		4		EU EA WA	410
--	rs2788945^1,2	A	132916976(-)	`cctggA/Gcaaca`	1	--	ng3¹		0	--	--	--	--
--	rs2788946^1,2	A	132916928(-)	`aaagaA/Gaagaa`	1	--	ng3¹		0	--	--	--	--
	rs6912620^1,2	H	132915635(+)	`ACGGCG/ATTTAG`	1	A/A	syn¹		4		EU EA WA	414
--	rs41286166^1,2	--	132916386(+)	`TGACCC/GCTGCC`	1	P/A	mis¹		0	--	--	--	--
--	rs67983654^1,2	--	132916936(+)	`TTTTC-/TTTTTTT`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for TAAR8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606927

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for TAAR8 gene:

Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)^{2, 3, 4} Lee D.K....O'Dowd B.F. (2001)
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)^{2, 3} Lindemann L....Hoener M.C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)^{3, 4} Borowsky B.... Gerald C. (2001)
A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)³ Liberles S.D. and Buck L.B. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83551	HGNC: 14964	AceView: TRAR5	Ensembl:ENSG00000146385	euGenes: HUgn83551
ECgene: TAAR8	H-InvDB: TAAR8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TAAR8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAAR8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAAR8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAAR8		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TAAR8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAAR8)
	Search for Antibodies
	Chimera RNAi (TAAR8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GPCR GPR102)
	Antibodies (GPCR GPR102)

Search OriGene for TAAR8

Search Tocris compounds for TAAR8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAAR8

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TAAR8 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for TAAR8

Summaries
for TAAR8

Genomic Location
for TAAR8

Proteins
for TAAR8

Protein Domains/
Families
for TAAR8

Gene Function
for TAAR8

Pathways & Interactions
for TAAR8

Drugs & Compounds
for TAAR8

Transcripts
for TAAR8

Expression
for TAAR8

Orthologs
for TAAR8

Paralogs
for TAAR8

SNPs/Variants
for TAAR8

Disorders & Mutations
for TAAR8

Medical News
for TAAR8

Publications
for TAAR8

Search for TAAR8

Genome Databases showing TAAR8

Other Databases showing TAAR8

Specialized Databases showing TAAR8

Licensable Technologies
for TAAR8

Services
for TAAR8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAAR8 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor TAAR8

Summariesfor TAAR8

Genomic Locationfor TAAR8

Proteinsfor TAAR8

Protein Domains/Familiesfor TAAR8

Gene Functionfor TAAR8

Pathways & Interactionsfor TAAR8

Drugs & Compoundsfor TAAR8

Transcriptsfor TAAR8

Expression for TAAR8

Orthologsfor TAAR8

Paralogsfor TAAR8

SNPs/Variantsfor TAAR8

Disorders & Mutationsfor TAAR8

Medical Newsfor TAAR8

Publicationsfor TAAR8

Search for TAAR8

Genome Databases showing TAAR8

Other Databases showing TAAR8

Specialized Databases showing TAAR8

Licensable Technologiesfor TAAR8

Servicesfor TAAR8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAAR8

Summaries
for TAAR8

Genomic Location
for TAAR8

Proteins
for TAAR8

Protein Domains/
Families
for TAAR8

Gene Function
for TAAR8

Pathways & Interactions
for TAAR8

Drugs & Compounds
for TAAR8

Transcripts
for TAAR8

Expression
for TAAR8

Orthologs
for TAAR8

Paralogs
for TAAR8

SNPs/Variants
for TAAR8

Disorders & Mutations
for TAAR8

Medical News
for TAAR8

Publications
for TAAR8

Licensable Technologies
for TAAR8

Services
for TAAR8