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Aliases for TAAR6 Gene

Aliases for TAAR6 Gene

  • Trace Amine Associated Receptor 6 2 3 5
  • Trace Amine Receptor 4 2 3 4
  • Trace Amine Receptor 6 3 4
  • TaR-4 3 4
  • TaR-6 3 4
  • TRAR4 3 4
  • TAR4 3 4
  • TA4 3 4
  • Trace Amine-Associated Receptor 6 3
  • TAR6 3

External Ids for TAAR6 Gene

Previous HGNC Symbols for TAAR6 Gene

  • TRAR4

Previous GeneCards Identifiers for TAAR6 Gene

  • GC06P132934
  • GC06P130466

Summaries for TAAR6 Gene

Entrez Gene Summary for TAAR6 Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

GeneCards Summary for TAAR6 Gene

TAAR6 (Trace Amine Associated Receptor 6) is a Protein Coding gene. Diseases associated with TAAR6 include Schizophrenia and Cyclosporiasis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR8.

UniProtKB/Swiss-Prot for TAAR6 Gene

  • Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

Gene Wiki entry for TAAR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR6 Gene

Genomics for TAAR6 Gene

Regulatory Elements for TAAR6 Gene

Enhancers for TAAR6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F132489 1.6 FANTOM5 Ensembl ENCODE 1.6 -79.5 -79469 2.9 PKNOX1 NFRKB DMAP1 ZSCAN9 DNMT3B YY1 ZNF335 ZNF766 MIXL1 CBFB STX7 MOXD1 VNN1 VNN2 TAAR6 TAAR5 SLC18B1
GH06F132287 0.3 FANTOM5 3.8 -282.6 -282614 0.1 TAAR6 TAAR5 GC06M132077 EEF1A1P36
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAAR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAAR6 Gene

Chromosome:
6
Start:
132,570,322 bp from pter
End:
132,571,359 bp from pter
Size:
1,038 bases
Orientation:
Plus strand

Genomic View for TAAR6 Gene

Genes around TAAR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR6 Gene

Proteins for TAAR6 Gene

  • Protein details for TAAR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RI8-TAAR6_HUMAN
    Recommended name:
    Trace amine-associated receptor 6
    Protein Accession:
    Q96RI8
    Secondary Accessions:
    • Q5VUQ4

    Protein attributes for TAAR6 Gene

    Size:
    345 amino acids
    Molecular mass:
    38451 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR6 Gene

Post-translational modifications for TAAR6 Gene

  • Glycosylation at Asn 4 and Asn 19
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR6 Gene

Domains & Families for TAAR6 Gene

Gene Families for TAAR6 Gene

Protein Domains for TAAR6 Gene

Suggested Antigen Peptide Sequences for TAAR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RI8

UniProtKB/Swiss-Prot:

TAAR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR6: view

Function for TAAR6 Gene

Molecular function for TAAR6 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.

Gene Ontology (GO) - Molecular Function for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 15718104
genes like me logo Genes that share ontologies with TAAR6: view
genes like me logo Genes that share phenotypes with TAAR6: view

Animal Models for TAAR6 Gene

MGI Knock Outs for TAAR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAAR6

miRNA for TAAR6 Gene

miRTarBase miRNAs that target TAAR6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAAR6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAAR6 Gene

Localization for TAAR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAAR6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IC --
genes like me logo Genes that share ontologies with TAAR6: view

Pathways & Interactions for TAAR6 Gene

genes like me logo Genes that share pathways with TAAR6: view

Interacting Proteins for TAAR6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275198%0d%0a9606.ENSP00000430432%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000275198 Q96RI8-TAAR6_HUMAN for TAAR6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with TAAR6: view

No data available for SIGNOR curated interactions for TAAR6 Gene

Drugs & Compounds for TAAR6 Gene

(2) Drugs for TAAR6 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 353
corticosteroids Pharma 0
genes like me logo Genes that share compounds with TAAR6: view

Transcripts for TAAR6 Gene

mRNA/cDNA for TAAR6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR6 Gene

Trace amine associated receptor 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAAR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR6 Gene

No ASD Table

Relevant External Links for TAAR6 Gene

GeneLoc Exon Structure for
TAAR6
ECgene alternative splicing isoforms for
TAAR6

Expression for TAAR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAAR6 Gene

mRNA differential expression in normal tissues according to GTEx for TAAR6 Gene

This gene is overexpressed in Kidney - Cortex (x13.5), Brain - Amygdala (x12.7), and Whole Blood (x7.4).

NURSA nuclear receptor signaling pathways regulating expression of TAAR6 Gene:

TAAR6

SOURCE GeneReport for Unigene cluster for TAAR6 Gene:

Hs.434196

mRNA Expression by UniProt/SwissProt for TAAR6 Gene:

Q96RI8-TAAR6_HUMAN
Tissue specificity: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.
genes like me logo Genes that share expression patterns with TAAR6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAAR6 Gene

Orthologs for TAAR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAAR6 34
  • 98.65 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 86 (a)
OneToMany
LOC616737 34
  • 85.83 (n)
-- 35
  • 85 (a)
OneToMany
TAAR6 35
  • 84 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Taar6 34 16 35
  • 83.96 (n)
rat
(Rattus norvegicus)
Mammalia Taar6 34
  • 83.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii taar13a 35
  • 41 (a)
ManyToMany
Species where no ortholog for TAAR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR6 Gene

ENSEMBL:
Gene Tree for TAAR6 (if available)
TreeFam:
Gene Tree for TAAR6 (if available)

Paralogs for TAAR6 Gene

Paralogs for TAAR6 Gene

(12) SIMAP similar genes for TAAR6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAAR6 Gene

genes like me logo Genes that share paralogs with TAAR6: view

Variants for TAAR6 Gene

Sequence variations from dbSNP and Humsavar for TAAR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10085309 -- 132,569,014(+) AGTAG(G/T)AATCA upstream-variant-2KB
rs10681302 -- 132,571,671(+) TATTT(C/G/T)TTTTT downstream-variant-500B
rs11154685 -- 132,571,801(+) ATTTT(A/G)CCACA downstream-variant-500B
rs111876712 -- 132,571,356(+) CATAT(A/G)TAAGC reference, missense
rs112520582 -- 132,570,334(+) GCAAT(C/T)CATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAAR6 Gene

Variant ID Type Subtype PubMed ID
esv3890949 CNV loss 25118596

Variation tolerance for TAAR6 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAAR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAAR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAAR6 Gene

Disorders for TAAR6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TAAR6 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
cyclosporiasis
  • cyclospora infection
cervix carcinoma
  • cancer of cervix
- elite association - COSMIC cancer census association via MalaCards
Search TAAR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAAR6

Genetic Association Database (GAD)
TAAR6
Human Genome Epidemiology (HuGE) Navigator
TAAR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAAR6
genes like me logo Genes that share disorders with TAAR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAAR6 Gene

Publications for TAAR6 Gene

  1. TAAR 6 and HSP-70 variations associated with bipolar disorder. (PMID: 19766166) Pae C.U. … Serretti A. (Neurosci. Lett. 2009) 3 22 46 64
  2. Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample. (PMID: 17097106) Pae C.U. … Lerer B. (J Psychiatr Res 2008) 3 22 46 64
  3. TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study. (PMID: 18583103) Pae C.U. … Serretti A. (Eur. Psychiatry 2008) 3 22 46 64
  4. No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. (PMID: 18628684) Ludewick H.P. … Wildenauer D.B. (Psychiatr. Genet. 2008) 3 22 46 64
  5. A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. (PMID: 17505468) Vladimirov V. … Riley B.P. (Mol. Psychiatry 2007) 3 22 46 64

Products for TAAR6 Gene

Sources for TAAR6 Gene

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