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TAAR6 Gene

protein-coding   GIFtS: 53
GCID: GC06P132934

Trace Amine Associated Receptor 6

(Previous name: trace amine receptor 4)
(Previous symbol: TRAR4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trace Amine Associated Receptor 61 2     TAR62
TRAR41 2 3 5     taR-42
Trace Amine Receptor 41 2 3     taR-62
Trace Amine Receptor 62 3     Trace Amine-Associated Receptor 62
TA42 3     TaR-43
TAR42 3     TaR-63

External Ids:    HGNC: 209781   Entrez Gene: 3191002   Ensembl: ENSG000001463837   OMIM: 6089235   UniProtKB: Q96RI83   

Export aliases for TAAR6 gene to outside databases

Previous GC identifer: GC06P130466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAAR6 Gene:
This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for
endogenous trace amines. Mutations in this gene may be associated with schizophrenia.(provided by RefSeq, Feb
2010)

GeneCards Summary for TAAR6 Gene:
TAAR6 (trace amine associated receptor 6) is a protein-coding gene. Diseases associated with TAAR6 include schizophrenia, and schizoaffective disorder. GO annotations related to this gene include trace-amine receptor activity and G-protein coupled receptor activity. An important paralog of this gene is HTR6.

UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8
Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very
low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in
invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained
speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be
fully understood

Gene Wiki entry for TAAR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAAR6 gene promoter:
         E2F-3a   E2F-4   E2F-5   SREBP-1c   MyoD   E2F-2   c-Rel   E2F-1   E2F   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAAR6 promoter sequence
   Search Chromatin IP Primers for TAAR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAAR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.1

TAAR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAAR6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P132934:  view genomic region     (about GC identifiers)

Start:
132,891,461 bp from pter      End:
132,892,498 bp from pter
Size:
1,038 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8 (See protein sequence)
Recommended Name: Trace amine-associated receptor 6  
Size: 345 amino acids; 38451 Da
Secondary accessions: Q5VUQ4

Explore the universe of human proteins at neXtProt for TAAR6: NX_Q96RI8

Explore proteomics data for TAAR6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn19
  • Modification sites at PhosphoSitePlus

  • See TAAR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778237.1  
    ENSEMBL proteins: 
     ENSP00000275198  
    Reactome Protein details: Q96RI8

    TAAR6 Human Recombinant Protein Products:

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    TAAR6 Assay Products:

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    Cloud-Clone Corp. CLIAs for TAAR6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TAAR: GPCR / Class A : Trace amine associated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAAR6
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009132 TAAR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96RI8

    ProtoNet protein and cluster: Q96RI8

    UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    TAAR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAAR6_HUMAN, Q96RI8
    Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very
    low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in
    invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained
    speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be
    fully understood

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001594trace-amine receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS15718104
         
    TAAR6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAAR6:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Taar6 (no phenotypes)

    TAAR6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAAR6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAAR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAAR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAAR6

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAAR6:
    hsa-mir-181a-5p (MIRT025149)

    Block miRNA regulation of human, mouse, rat TAAR6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TAAR6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TAAR6

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    GenScript: all cDNA clones in your preferred vector: TAAR6 (NM_175067)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAAR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAAR6_HUMAN, Q96RI8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    TAAR6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAAR6 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Monoamine GPCRs
    Amine ligand-binding receptors0.79
    4G alpha (s) signalling events
    G alpha (s) signalling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TAAR6
        G alpha (s) signalling events
    Amine ligand-binding receptors


    1 Kegg Pathway  (Kegg details for TAAR6):
        Neuroactive ligand-receptor interaction


    TAAR6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TAAR6: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TAAR6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TAAR6 (ENSP000002751984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS15718104

    TAAR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAAR6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAAR6 gene: 
    NM_175067.1  

    Unigene Cluster for TAAR6:

    Trace amine associated receptor 6
    Hs.434196  [show with all ESTs]
    Unigene Representative Sequence: AY183470
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000275198(uc011eck.2)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAAR6
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAAR6 (NM_175067)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAAR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR6
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAAR6
      QuantiTect SYBR Green Assays in human, mouse, rat TAAR6
      QuantiFast Probe-based Assays in human, mouse, rat TAAR6

    Additional mRNA sequence: 

    AY183470.1 BC069157.1 

    1 DOTS entry:

    DT.99947180 

    3 AceView cDNA sequences:

    BC069157 AY183470 NM_175067 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAAR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTGTTTT
    TAAR6 Expression
    About this image

    TAAR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAAR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434196

    UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8
    Tissue specificity: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the
    cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex,
    substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal
    ganglia

        Pathway & Disease-focused RT2 Profiler PCR Array including TAAR6: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TAAR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAAR6
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    QuantiFast Probe-based Assays in human, mouse, rat TAAR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAAR6 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taar61 , 5 trace amine-associated receptor 61, 5 83.96(n)1
    88.7(a)1
      10 (11.40 cM)5
    2158551  NM_001010828.11  NP_001010828.11 
     239846095 
    zebrafish
    (Danio rerio)
    Actinopterygii taar13a6
    trace amine associated receptor 13a
    41(a)
    many ↔ many
    20(46148101-46149128) ENSDARG00000092734


    ENSEMBL Gene Tree for TAAR6 (if available)
    TreeFam Gene Tree for TAAR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAAR6 gene
    HTR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  DRD12  TAAR12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    12 SIMAP similar genes for TAAR6 using alignment to 1 protein entry:     TAAR6_HUMAN:
    TAAR8    TAAR9    TAAR5    TAAR1    TAAR3    TAAR2
    ADRB2    HTR4    HTR4B    HRH2    DRD1    ADRA1A

    TAAR6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAAR6
    PGOHUM00000243777


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAAR6 (see all 162)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143584751,2
    C,F--132890728(+) GTCTCA/GTCTGC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1144350741,2
    C--132890824(+) TTCCTC/TAAGTT 1 -- us2k10--------
    rs729856161,2
    C--132890873(+) TGGTCA/CTAACA 1 -- us2k10--------
    rs800099271,2
    F--132890881(+) ACAGTT/ATTGTT 1 -- us2k12Minor allele frequency- A:0.13CSA WA 120
    rs1407498611,2
    C--132891027(+) TATTGC/TCTAAG 1 -- us2k10--------
    rs1832062121,2
    C--132891069(+) TTTGTC/TCCTTG 1 -- us2k10--------
    rs93758971,2
    C,F,A,H--132891292(+) ATCAGA/TCATAC 1 -- us2k17Minor allele frequency- T:0.47WA NA EA 366
    rs93213521,2
    C,F,A,H--132891296(+) GACATT/ACAGAA 1 -- us2k1 tfbs38Minor allele frequency- A:0.42WA NA CSA EA 367
    rs1179987511,2
    F--132891298(+) CATACA/GGAAAA 1 -- us2k11Minor allele frequency- G:0.06NA 120
    rs604546301,2
    --132891313(+) AAGAAA/GCATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAAR6 (132891461 - 132892498 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAAR6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAAR6
    DNA2.0 Custom Variant and Variant Library Synthesis for TAAR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608923    OMIM disorders: --

    8 diseases for TAAR6:    
    About MalaCards
    schizophrenia    schizoaffective disorder    cervical squamous cell carcinoma    cleft lip
    mood disorder    bipolar disorder    cervicitis    squamous cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for TAAR6:
    Schizophrenia     Schizoaffective disorder

    TAAR6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAAR6
    Human Genome Epidemiology (HuGE) Navigator: TAAR6 (13 documents)

    Export disorders for TAAR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAAR6 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TAAR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)1, 2, 3 Borowsky B.... Gerald C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample. (PubMed id 17097106)1, 4, 9 Pae C.U....Lerer B. (J Psychiatr Res 2008)
    3. Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. (PubMed id 15329799)1, 2, 9 Duan J.... Gejman P.V. (Am. J. Hum. Genet. 2004)
    4. No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. (PubMed id 18628684)1, 4, 9 Ludewick H.P....Wildenauer D.B. (Psychiatr. Genet. 2008)
    5. A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. (PubMed id 17505468)1, 4, 9 Vladimirov V....Riley B.P. (Mol. Psychiatry 2007)
    6. TAAR 6 and HSP-70 variations associated with bipolar disorder. (PubMed id 19766166)1, 4, 9 Pae C.U....Serretti A. (Neurosci. Lett. 2009)
    7. TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study. (PubMed id 18583103)1, 4, 9 Pae C.U....Serretti A. (Eur. Psychiatry 2008)
    8. The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. (PubMed id 18973992)1, 4 Vladimirov V.I....Riley B.P. (Schizophr. Res. 2009)
    9. Influence of TAAR6 polymorphisms on response to aripiprazole. (PubMed id 19345712)1, 4 Serretti A....De Ronchi D. (amp 2009)
    10. Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment. (PubMed id 19643584)1, 4 Pae C.U....Serretti A. (Eur Neuropsychopharmacol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 319100 HGNC: 20978 AceView: TRAR4 Ensembl:ENSG00000146383 euGenes: HUgn319100
    ECgene: TAAR6 Kegg: 319100 H-InvDB: TAAR6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAAR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAAR6 gene:
    Search GeneIP for patents involving TAAR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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