TAAR6 Gene
protein-coding GIFtS: 52
GCID: GC06P132934
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trace amine associated receptor 6(Previous name: trace amine receptor 4 )
(Previous symbol: TRAR4)
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Aliases
for TAAR6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trace Amine Associated Receptor 61 2 | | TAR62 | | TRAR41 2 3 5 | | TaR-43 | | Trace Amine Receptor 41 2 3 | | TaR-63 | | TA41 2 3 | | Trace Amine-Associated Receptor 62 | | Trace Amine Receptor 62 3 | | TaR-43 | | TAR42 3 | | TaR-63 | | RP11-295F4.32 | | |
Export aliases for TAAR6 gene to outside databasesPrevious GC identifer: GC06P130466 |
Summaries
for TAAR6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAAR6:
This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenoustrace amines. Mutations in this gene may be associated with schizophrenia.(provided by RefSeq, Feb 2010)
UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Gene Wiki entry for TAAR6
|
Genomic Views
for TAAR6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAAR6 gene promoter:
E2F-3a E2F-4 E2F-5 SREBP-1c MyoD E2F-2 c-Rel E2F-1 E2F FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAAR6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.1TAAR6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P132934: view genomic region
(about GC identifiers)
Start:
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132,891,461 bp from pter |
End:
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132,892,498 bp from pter |
Size:
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1,038 bases |
Orientation:
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plus strand |
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Proteins
for TAAR6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8 (See
protein sequence)Recommended Name: Trace amine-associated receptor 6 Size: 345 amino acids; 38451 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5VUQ4Explore the universe of human proteins at neXtProt for TAAR6: NX_Q96RI8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96RI8
TAAR6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778237.1
ENSEMBL proteins: ENSP00000275198 Reactome Protein details: Q96RI8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TAAR6 for ontologies About GeneDecksing
TAAR6 Antibody Products:
Assay Products for TAAR6: |
Protein
Domains /
Families
for TAAR6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAAR6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96RI8ProtoNet protein and cluster: Q96RI8 UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TAAR6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very lowlevels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters ininvertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TAAR6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 15718104 |
TAAR6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TAAR6:
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Pathways & Interactions
for TAAR6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Monoamine GPCRs | | | 4 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for TAAR6 (see all 7)
1 
Kegg Pathway (Kegg details for TAAR6):
TAAR6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAAR6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TAAR6 (ENSP000002751984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 15718104 |
TAAR6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAAR6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAAR6
Search CenterWatch for drugs/clinical trials and news about TAAR6
|
Transcripts
for TAAR6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAAR6 gene: NM_175067.1 Unigene Cluster for TAAR6: Trace amine associated receptor 6 Hs.434196 [show with all ESTs]Unigene Representative Sequence: AY1834701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000275198(uc011eck.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAAR6 (NM_175067) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR6 |
Additional cDNA sequence: AY183470.1 BC069157.1 1 DOTS entry: DT.99947180 3 AceView cDNA sequences: BC069157 AY183470 NM_175067
GeneLoc Exon Structure
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Expression
for TAAR6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAAR6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTGTTTT
About this image
See TAAR6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.434196
UniProtKB/Swiss-Prot: TAAR6_HUMAN, Q96RI8Tissue specificity: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in thecerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantianigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia
SABiosciences Expression via Pathway-Focused PCR Array including TAAR6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAAR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR6 |
Orthologs
for TAAR6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAAR6 gene from 1/8 species (see all 8) About this table
ENSEMBL Gene Tree for TAAR6 (if available)
TreeFam Gene Tree for TAAR6 (if available) |
Paralogs
for TAAR6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAAR6 gene
- HTR2A2 HTR62 TAAR22 ADRB12 TAAR82 HRH22 HTR2B2 DRD12
- HTR2C2 TAAR12 ADRB22 HTR42 DRD52 ADRB32 TAAR52
13 SIMAP similar genes for TAAR6 using alignment to 1 protein entry: TAAR6_HUMAN:TAAR8 TAAR9 TAAR5 TAAR1 TAAR3 TAAR2
ADRB2 HTR4 HTR4B HRH2 DRD1 ADRA1A
HTR1D
TAAR6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TAAR6
PGOHUM00000243777
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Genomic Variants
for TAAR6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAAR6 (132891461 - 132892498 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAAR6
1 CNV: 81597 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR6 |
|
Disorders
/ Diseases
for TAAR6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAAR6 for disorders About GeneDecksing
OMIM gene information: 608923
OMIM disorders: --
10  diseases for TAAR6: About MalaCardscleft lip/palate schizophrenia cleft lip bipolar affective disorder
cervical squamous cell carcinoma squamous cell carcinoma mood disorder bipolar disorder
cervicitis carcinoma
2 diseases from the University of Copenhagen DISEASES database for TAAR6:Schizophrenia Schizoaffective disorder Genetic Association Database (GAD): TAAR6
Human Genome Epidemiology (HuGE) Navigator: TAAR6 (13 documents)
Export disorders for TAAR6 gene to outside databases
|
Publications
for TAAR6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAAR6 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with TAAR6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)1, 2, 3 Borowsky B.... Gerald C. (2001)
- Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. (PubMed id 15329799)1, 2, 9 Duan J.... Gejman P.V. (2004)
- Failure to find association between TRAR4 and schizophrenia in the Chinese Han population. (PubMed id 16075187)1, 4 Duan S....He L. (2006)
- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 3 Lindemann L....Hoener M.C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample. (PubMed id 17097106)1, 9 Pae C.U....Lerer B. (2008)
- Investigation of an epistastic effect between a set o f TAAR6 and HSP-70 genes variations and major mood disorders. (PubMed id 19582769)1, 9 Pae C.U....Serretti A. (2010)
- No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. (PubMed id 18628684)1, 9 Ludewick H.P....Wildenauer D.B. (2008)
- A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. (PubMed id 17505468)1, 9 Vladimirov V....Riley B.P. (2007)
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External Searches for TAAR6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAAR6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAAR6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAAR6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAAR6 gene:
Search GeneIP for patents involving TAAR6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAAR6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for TAAR6 | | OriGene Custom Protein Services for TAAR6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAAR6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAAR6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR6 |
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 | | | TAAR6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR6 |
|  |  |  | | | | ThermoFisher Antibodies for TAAR6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR6 |
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