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Aliases for TAAR6 Gene

Aliases for TAAR6 Gene

  • Trace Amine Associated Receptor 6 2 3
  • Trace Amine Receptor 4 2 3 4
  • TRAR4 3 4 6
  • Trace Amine Receptor 6 3 4
  • TaR-4 3 4
  • TaR-6 3 4
  • TAR4 3 4
  • TA4 3 4
  • Trace Amine-Associated Receptor 6 3
  • TAR6 3

External Ids for TAAR6 Gene

Previous Symbols for TAAR6 Gene

  • TRAR4

Summaries for TAAR6 Gene

Entrez Gene Summary for TAAR6 Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

GeneCards Summary for TAAR6 Gene

TAAR6 (Trace Amine Associated Receptor 6) is a Protein Coding gene. Diseases associated with TAAR6 include schizophrenia and mood disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for TAAR6 Gene

  • Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood

Gene Wiki entry for TAAR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR6 Gene

Genomics for TAAR6 Gene

Genomic Location for TAAR6 Gene

Start:
132,570,322 bp from pter
End:
132,571,359 bp from pter
Size:
1,038 bases
Orientation:
Plus strand

Genomic View for TAAR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAAR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR6 Gene

Regulatory Elements for TAAR6 Gene

Proteins for TAAR6 Gene

  • Protein details for TAAR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RI8-TAAR6_HUMAN
    Recommended name:
    Trace amine-associated receptor 6
    Protein Accession:
    Q96RI8
    Secondary Accessions:
    • Q5VUQ4

    Protein attributes for TAAR6 Gene

    Size:
    345 amino acids
    Molecular mass:
    38451 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR6 Gene

Proteomics data for TAAR6 Gene at MOPED

Post-translational modifications for TAAR6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4 and Asn19

Other Protein References for TAAR6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR6 Gene

Domains for TAAR6 Gene

Gene Families for TAAR6 Gene

HGNC:
  • TAAR :GPCR / Class A : Trace amine associated receptors
IUPHAR :

Protein Domains for TAAR6 Gene

UniProtKB/Swiss-Prot:

TAAR6_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96RI8
genes like me logo Genes that share domains with TAAR6: view

Function for TAAR6 Gene

Molecular function for TAAR6 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood

Gene Ontology (GO) - Molecular Function for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 15718104
genes like me logo Genes that share ontologies with TAAR6: view

Phenotypes for TAAR6 Gene

GenomeRNAi human phenotypes for TAAR6:
genes like me logo Genes that share phenotypes with TAAR6: view

miRNA for TAAR6 Gene

miRTarBase miRNAs that target TAAR6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAAR6 Gene

Localization for TAAR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAAR6 Gene COMPARTMENTS Subcellular localization image for TAAR6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 15718104
genes like me logo Genes that share ontologies with TAAR6: view

Pathways for TAAR6 Gene

genes like me logo Genes that share pathways with TAAR6: view

Pathways by source for TAAR6 Gene

Interacting Proteins for TAAR6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000275198%0d%0a9606.ENSP00000430432%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000275198 for TAAR6 Gene via STRING

Gene Ontology (GO) - Biological Process for TAAR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 15718104
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TAAR6: view

Transcripts for TAAR6 Gene

mRNA/cDNA for TAAR6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR6 Gene

Trace amine associated receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR6 Gene

No ASD Table

Relevant External Links for TAAR6 Gene

GeneLoc Exon Structure for
TAAR6
ECgene alternative splicing isoforms for
TAAR6

Expression for TAAR6 Gene

mRNA expression in normal human tissues for TAAR6 Gene

mRNA differential expression in normal tissues according to GTEx for TAAR6 Gene

This gene is overexpressed in Kidney - Cortex (13.5), Brain - Amygdala (12.7), and Whole Blood (7.4).

SOURCE GeneReport for Unigene cluster for TAAR6 Gene Hs.434196

mRNA Expression by UniProt/SwissProt for TAAR6 Gene

Q96RI8-TAAR6_HUMAN
Tissue specificity: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia.
genes like me logo Genes that share expressions with TAAR6: view

Orthologs for TAAR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAAR6 36
  • 98.65 (n)
  • 97.68 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
LOC616737 36
  • 85.83 (n)
  • 86.51 (a)
TAAR6 37
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Taar6 36
  • 83.96 (n)
  • 88.7 (a)
Taar6 16
Taar6 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 72 (a)
ManyToMany
-- 37
  • 75 (a)
ManyToMany
-- 37
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Taar6 36
  • 83.19 (n)
  • 87.54 (a)
zebrafish
(Danio rerio)
Actinopterygii taar13a 37
  • 41 (a)
ManyToMany
Species with no ortholog for TAAR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR6 Gene

ENSEMBL:
Gene Tree for TAAR6 (if available)
TreeFam:
Gene Tree for TAAR6 (if available)

Paralogs for TAAR6 Gene

Paralogs for TAAR6 Gene

Selected SIMAP similar genes for TAAR6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAAR6 Gene

genes like me logo Genes that share paralogs with TAAR6: view

Variants for TAAR6 Gene

Sequence variations from dbSNP and Humsavar for TAAR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6907909 -- 132,569,609(+) TTACT(A/G)TTTAC upstream-variant-2KB
rs7752618 -- 132,571,404(+) CCAAG(C/G)GAAAT downstream-variant-500B
rs7772821 -- 132,571,367(+) AGTTG(G/T)ATAGA downstream-variant-500B
rs8192622 -- 132,570,399(+) ATCCC(C/T)TTCTC reference, synonymous-codon
rs8192623 -- 132,570,311(+) TGTAA(A/G)TAACA upstream-variant-2KB

Relevant External Links for TAAR6 Gene

HapMap Linkage Disequilibrium report
TAAR6

No data available for Structural Variations from Database of Genomic Variants (DGV) for TAAR6 Gene

Disorders for TAAR6 Gene

(2) MalaCards Diseases for TAAR6 Gene

Search for TAAR6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TAAR6 Gene

Relevant External Links for TAAR6

Genetic Association Database (GAD)
TAAR6
Human Genome Epidemiology (HuGE) Navigator
TAAR6
genes like me logo Genes that share disorders with TAAR6: view

No data available for UniProtKB/Swiss-Prot for TAAR6 Gene

Publications for TAAR6 Gene

  1. Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample. (PMID: 17097106) Pae C.U. … Lerer B. (J Psychiatr Res 2008) 3 23 49
  2. A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. (PMID: 17505468) Vladimirov V. … Riley B.P. (Mol. Psychiatry 2007) 3 23 49
  3. TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study. (PMID: 18583103) Pae C.U. … Serretti A. (Eur. Psychiatry 2008) 3 23 49
  4. No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. (PMID: 18628684) Ludewick H.P. … Wildenauer D.B. (Psychiatr. Genet. 2008) 3 23 49
  5. Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. (PMID: 15329799) Duan J. … Gejman P.V. (Am. J. Hum. Genet. 2004) 3 4 23

Products for TAAR6 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TAAR6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TAAR6
    • Block miRNA regulation of TAAR6 using miScript Target Protectors

    Sources for TAAR6 Gene

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