TAAR5 Gene
protein-coding GIFtS: 51
GCID: GC06M132910
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|
trace amine associated receptor 5
| |
Aliases
for TAAR5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trace Amine Associated Receptor 51 2 | | RP11-295F4.52 | | PNR1 2 3 5 | | TaR-53 | | Putative Neurotransmitter Receptor2 3 | | Trace Amine-Associated Receptor 52 | | Trace Amine Receptor 52 3 | | TaR-53 |
Export aliases for TAAR5 gene to outside databasesPrevious GC identifers: GC06M132952 GC06M130484 |
Summaries
for TAAR5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804Function: Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as,e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) orbeing any kind of metabolite of amino acids or biogenic amine neurotransmitters
Gene Wiki entry for TAAR5
|
Genomic Views
for TAAR5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAAR5 gene promoter:
Egr-2 Pbx1a AML1a Tal-1 p300 Bach2 Tal-1beta E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAAR5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2TAAR5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M132910: view genomic region
(about GC identifiers)
Start:
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132,909,731 bp from pter |
End:
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132,910,877 bp from pter |
Size:
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1,147 bases |
Orientation:
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minus strand |
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Proteins
for TAAR5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804 (See
protein sequence)Recommended Name: Trace amine-associated receptor 5 Size: 337 amino acids; 38242 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: D8KZS1 Q2M1V1 Q4VBL1 Q5VUQ3 Q6NTA8Explore the universe of human proteins at neXtProt for TAAR5: NX_O14804
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14804
TAAR5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003958.2
ENSEMBL proteins: ENSP00000258034 Reactome Protein details: O14804
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TAAR5 for ontologies About GeneDecksing
TAAR5 Antibody Products:
Assay Products for TAAR5: |
Protein
Domains /
Families
for TAAR5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAAR5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14804ProtoNet protein and cluster: O14804 1 Blocks protein family: IPB001917 Aminotransferase
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TAAR5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804Function: Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as,e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) orbeing any kind of metabolite of amino acids or biogenic amine neurotransmitters
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TAAR5 (NM_003967) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 15718104 |
TAAR5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TAAR5:
Animal Models:
Mouse knock-out Taar5tm1(KOMP)Vlcg for TAAR5
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Taar5):
TAAR5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TAAR5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | GPCRs, Other | | | 4 | Monoamine GPCRs | | | 5 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TAAR5
5/7 
Reactome Pathways for TAAR5 (see all 7)
1 
Kegg Pathway (Kegg details for TAAR5):
TAAR5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAAR5
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TAAR5 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAAR5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAAR5
Search CenterWatch for drugs/clinical trials and news about TAAR5
|
Transcripts
for TAAR5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAAR5 gene: NM_003967.2 Unigene Cluster for TAAR5: Trace amine associated receptor 5 Hs.248198 [show with all ESTs]Unigene Representative Sequence: NM_0039671 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000258034(uc003qdk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAAR5 (NM_003967) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR5 |
Additional cDNA sequence: AF021818.1 BC069171.1 BC095541.1 BC112209.1 BC112211.1 1 DOTS entry: DT.102820214 5 AceView cDNA sequences: BC069171 NM_003967 CN839009 CN839222 AF021818
GeneLoc Exon Structure
|
Expression
for TAAR5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAAR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGAAAAGC
About this image
See TAAR5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAAR5
SOURCE GeneReport for Unigene cluster: Hs.248198
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804Tissue specificity: Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala,hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra
SABiosciences Expression via Pathway-Focused PCR Array including TAAR5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAAR5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR5 |
Orthologs
for TAAR5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAAR5 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for TAAR5 (if available)
TreeFam Gene Tree for TAAR5 (if available) |
Paralogs
for TAAR5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAAR5 gene
- TAAR62 HTR2A2 HTR62 TAAR22 ADRB12 TAAR82 HRH22 HTR2B2
- DRD12 HTR2C2 TAAR12 ADRB22 HTR42 DRD52 ADRB32
10 SIMAP similar genes for TAAR5 using alignment to 1 protein entry: TAAR5_HUMAN:TAAR2 TAAR6 TAAR9 TAAR8 TAAR1 TAAR3
HTR4 HTR4B HRH2 ADRB2
TAAR5 for paralogs About GeneDecksing
|
Genomic Variants
for TAAR5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAAR5 (132909731 - 132910877 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TAAR5
6 CNVs: 94021 81597 94025 81596 81594 94019 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR5 |
|
Disorders
/ Diseases
for TAAR5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TAAR5 for disorders About MalaCards
TAAR5 for disorders About GeneDecksing
OMIM gene information: 607405
OMIM disorders: --
Export disorders for TAAR5 gene to outside databases
|
Publications
for TAAR5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAAR5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAAR5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 2, 3 Lindemann L....Hoener M.C. (2005)
- Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. (PubMed id 9464258)1, 2, 3 Zeng Z....Li Y. (1998)
- Structural and functional evolution of the trace amin e-associated receptors TAAR3, TAAR4 and TAAR5 in primates. (PubMed id 20559446)1, 2 StAoubert C....SchAPneberg T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)1 Liberles S.D. and Buck L.B. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Biogenic Trace Amine-Associated Receptors (TAARS) are encoded in avian genomes: evidence and possible implications. (PubMed id 18296390)9 Mueller J.C....Kempenaers B. (2008)
|
External Searches for TAAR5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAAR5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAAR5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAAR5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAAR5 gene:
Search GeneIP for patents involving TAAR5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAAR5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TAAR5 | | OriGene shRNA RFP for TAAR5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAAR5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR5 | | | OriGene Protein Over-expression Lysate for TAAR5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAAR5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAAR5 | | OriGene Custom Protein Services for TAAR5 | | | OriGene Custom Immunoassay Development | | |
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 | | | TAAR5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR5 |
|  |  |  | | | | ThermoFisher Antibodies for TAAR5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR5 |
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