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Aliases for TAAR5 Gene

Aliases for TAAR5 Gene

  • Trace Amine Associated Receptor 5 2 3 5
  • Putative Neurotransmitter Receptor 3 4
  • Trace Amine Receptor 5 3 4
  • HTaar5 3 4
  • TaR-5 3 4
  • PNR 3 4

External Ids for TAAR5 Gene

Previous GeneCards Identifiers for TAAR5 Gene

  • GC06M132952
  • GC06M132910
  • GC06M130484

Summaries for TAAR5 Gene

GeneCards Summary for TAAR5 Gene

TAAR5 (Trace Amine Associated Receptor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and trimethylamine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for TAAR5 Gene

  • Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Gene Wiki entry for TAAR5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR5 Gene

Genomics for TAAR5 Gene

Regulatory Elements for TAAR5 Gene

Genomic Location for TAAR5 Gene

Chromosome:
6
Start:
132,588,592 bp from pter
End:
132,589,738 bp from pter
Size:
1,147 bases
Orientation:
Minus strand

Genomic View for TAAR5 Gene

Genes around TAAR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR5 Gene

Proteins for TAAR5 Gene

  • Protein details for TAAR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14804-TAAR5_HUMAN
    Recommended name:
    Trace amine-associated receptor 5
    Protein Accession:
    O14804
    Secondary Accessions:
    • D8KZS1
    • Q2M1V1
    • Q4VBL1
    • Q5VUQ3
    • Q6NTA8

    Protein attributes for TAAR5 Gene

    Size:
    337 amino acids
    Molecular mass:
    38242 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Polymorphic variants of this gene are not associated with specific anosmia for trimethylamine.

neXtProt entry for TAAR5 Gene

Proteomics data for TAAR5 Gene at MOPED

Post-translational modifications for TAAR5 Gene

  • Glycosylation at Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAAR5 Gene

Domains & Families for TAAR5 Gene

Gene Families for TAAR5 Gene

Protein Domains for TAAR5 Gene

Suggested Antigen Peptide Sequences for TAAR5 Gene

Graphical View of Domain Structure for InterPro Entry

O14804

UniProtKB/Swiss-Prot:

TAAR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR5: view

Function for TAAR5 Gene

Molecular function for TAAR5 Gene

UniProtKB/Swiss-Prot Function:
Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Gene Ontology (GO) - Molecular Function for TAAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990081 trimethylamine receptor activity IEA,IDA 23393561
genes like me logo Genes that share ontologies with TAAR5: view
genes like me logo Genes that share phenotypes with TAAR5: view

Animal Models for TAAR5 Gene

MGI Knock Outs for TAAR5:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAAR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAAR5 Gene

Localization for TAAR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAAR5 Gene COMPARTMENTS Subcellular localization image for TAAR5 gene
Compartment Confidence
plasma membrane 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TAAR5 Gene

Pathways & Interactions for TAAR5 Gene

genes like me logo Genes that share pathways with TAAR5: view

Pathways by source for TAAR5 Gene

Interacting Proteins for TAAR5 Gene

Gene Ontology (GO) - Biological Process for TAAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9464258
genes like me logo Genes that share ontologies with TAAR5: view

No data available for SIGNOR curated interactions for TAAR5 Gene

Drugs & Compounds for TAAR5 Gene

No Compound Related Data Available

Transcripts for TAAR5 Gene

mRNA/cDNA for TAAR5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR5 Gene

Trace amine associated receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR5 Gene

No ASD Table

Relevant External Links for TAAR5 Gene

GeneLoc Exon Structure for
TAAR5
ECgene alternative splicing isoforms for
TAAR5

Expression for TAAR5 Gene

mRNA expression in normal human tissues for TAAR5 Gene

SOURCE GeneReport for Unigene cluster for TAAR5 Gene Hs.248198

mRNA Expression by UniProt/SwissProt for TAAR5 Gene

O14804-TAAR5_HUMAN
Tissue specificity: Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra.
genes like me logo Genes that share expression patterns with TAAR5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TAAR5 Gene

Orthologs for TAAR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAAR5 35
  • 99.01 (n)
  • 98.81 (a)
TAAR5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAAR5 36
  • 84 (a)
OneToOne
TAAR5 35
  • 86.84 (n)
  • 84.27 (a)
dog
(Canis familiaris)
Mammalia TAAR5 35
  • 89.81 (n)
  • 87.83 (a)
TAAR5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taar5 16
Taar5 36
  • 87 (a)
OneToOne
Taar5 35
  • 85.36 (n)
  • 86.65 (a)
oppossum
(Monodelphis domestica)
Mammalia TAAR5 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Taar5 35
  • 84.87 (n)
  • 84.87 (a)
chicken
(Gallus gallus)
Aves TAAR5 35
  • 70.08 (n)
  • 71.74 (a)
TAAR5 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAAR5 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii taar13d 36
  • 41 (a)
ManyToMany
Species with no ortholog for TAAR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR5 Gene

ENSEMBL:
Gene Tree for TAAR5 (if available)
TreeFam:
Gene Tree for TAAR5 (if available)

Paralogs for TAAR5 Gene

Paralogs for TAAR5 Gene

(9) SIMAP similar genes for TAAR5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAAR5: view

Variants for TAAR5 Gene

Sequence variations from dbSNP and Humsavar for TAAR5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34746740 - 132,588,872(-) AGACA(C/G/T)GATGG reference, missense
rs35839363 - 132,588,699(-) AGACA(C/G/T)GCACT reference, missense
rs4487610 -- 132,591,248(+) TCTCT(A/G)CCTCT upstream-variant-2KB
rs4605911 -- 132,591,473(+) TGTTT(C/T)CCAAG upstream-variant-2KB
rs3813354 -- 132,589,495(-) AAAGC(A/G)CTTCA reference, synonymous-codon

Variation tolerance for TAAR5 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAAR5 Gene

HapMap Linkage Disequilibrium report
TAAR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAAR5 Gene

Disorders for TAAR5 Gene

Relevant External Links for TAAR5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAAR5

No disorders were found for TAAR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAAR5 Gene

Publications for TAAR5 Gene

  1. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3 4 67
  2. Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. (PMID: 9464258) Zeng Z. … Li Y. (Biochem. Biophys. Res. Commun. 1998) 2 3
  3. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. (PMID: 23393561) Wallrabenstein I. … Gisselmann G. (PLoS ONE 2013) 3
  4. Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. (PMID: 20559446) Staubert C. … Schoneberg T. (PLoS ONE 2010) 3
  5. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3

Products for TAAR5 Gene

Sources for TAAR5 Gene

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