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TAAR5 Gene

protein-coding GIFtS: 50

GC06M132952

trace amine associated receptor 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC138414 ^²
MGC138416 ^²
OTTHUMP00000017223 ^²
PNR ^¹, ², ³
RP11-295F4.5 ^²

Descriptions
Putative neurotransmitter receptor ^², ³
trace amine associated receptor 5 ^²

External Ids
HGNC: 30236¹
Entrez Gene: 9038²
UniProtKB: O14804³
Ensembl: ENSG00000135569⁷

Search outside databases for aliases for TAAR5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804

Function: Orphan receptor. Ligands are likely small molecules, either sharing some similarities

with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of

phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or

biogenic amine neurotransmitters

Gene Wiki entry for TAAR5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAAR5 gene

Entrez Gene cytogenetic band: 6q23 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2

TAAR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M132952: (about GC identifiers)

Start:	132,951,505 bp from pter
End:	132,952,915 bp from pter
Size:	1,411 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804 (See protein sequence)

Recommended Name: Trace amine-associated receptor 5

Size: 337 amino acids; 38242 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q2M1V1 Q4VBL1 Q5VUQ3 Q6NTA8

REFSEQ proteins: NP_003958.2

ENSEMBL proteins:

ENSP00000376198 ENSP00000258034

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PNR)
	Human Recombinant Proteins from Abnova (TAAR5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9464258

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Antibodies for TAAR5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TAAR5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PNR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TAAR5)
	Novus Biologicals Antibodies for TAAR5

Assays for TAAR5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14804

ProtoNet protein and cluster: O14804

1 Blocks protein family: IPB001917 Aminotransferase

UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003967

Applied Biosystems Silencer® siRNAs for TAAR5

Sigma-Aldrich siRNA and siRNA Panels for TAAR5

Sigma-Aldrich shRNA Panels and shRNA for TAAR5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TAAR5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003967
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003967
untagged cDNA clone in CMV expression vector: NM_003967

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003967

UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804

Function: Orphan receptor. Ligands are likely small molecules, either sharing some similarities

with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of

phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or

biogenic amine neurotransmitters

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	9464258

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Interacting proteins for TAAR5 (ENSP00000258034³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAAR2	ENSP00000356908³	STRING (score=.907)
TAAR1	ENSP00000275216³	STRING (score=.906)
TAAR6	ENSP00000275198³	STRING (score=.904)
TAAR8	ENSP00000275200³	STRING (score=.904)
STX7	ENSP00000309600³	STRING (score=.837)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9464258
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	9464258

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAAR5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAAR5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAAR5)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003967

Sigma-Aldrich siRNA and siRNA Panels for TAAR5

Sigma-Aldrich shRNA Panels and shRNA for TAAR5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003967

REFSEQ mRNAs for TAAR5 gene:

NM_003967.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003967

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003967
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003967
                                 untagged cDNA clone in CMV expression vector: NM_003967

Additional cDNA sequence:

AF021818.1 BC069171.1 BC095541.1 BC112209.1 BC112211.1

1 DOTS entry:

DT.102820214

5 AceView cDNA sequences:

BC069171 CN839009 AF021818 NM_003967 CN839222

highest scoring ESTs for TAAR5:

AF021818 BC069171 CN839009 CN839222 BC095541 NM_003967 BC112209 BC112211 CO928188 CO928206

Unigene Cluster for TAAR5:

Trace amine associated receptor 5

Hs.248198 [show with all ESTs]

Unigene Representative Sequence: NM_003967

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000392397 ENST00000258034

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAAR5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAAR5

¹ / ² / ³

2 probe-sets matching TAAR5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221459_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003967	0.60	1.00	0.82	1
221459_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAGAAAAGC

SOURCE GeneReport for Unigene cluster: Hs.248198
UniProtKB/Swiss-Prot: TAAR5_HUMAN, O14804
Tissue specificity: Expressed almost exclusively in skeletal muscle and selected areas of the
brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is
also find in substantia nigra

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAAR5 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TAAR5¹	--	trace amine associated receptor 5	89.52(n) 87.24(a)	483989 XM_541106.1 XP_541106.1
chimpanzee (Pan troglodytes)	TAAR5¹	--	trace amine associated receptor 5	98.81(n) 98.22(a)	472128 NM_001009126.1 NP_001009126.1
cow (Bos taurus)	TAAR5¹	--	trace amine associated receptor 5	86.75(n) 83.98(a)	509368 XM_586310.2 XP_586310.2
rat (Rattus norvegicus)	Taar5¹	--	trace amine-associated receptor 5	84.67(n) 84.27(a)	294123 NM_001009650.1 NP_001009650.1
mouse (Mus musculus)	Taar5^{1, 5}	10⁵	trace amine-associated receptor 5^{1, 5}	85.16(n)¹ 86.05(a)¹	215854¹ NM_001009574.1¹ NP_001009574.1¹ AY702329⁵ BC139188⁵ (see all 6)

About this table Species with no ortholog for TAAR5

ENSEMBL Gene Tree for TAAR5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in TAAR5 are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 71)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4487610^1,2	A,C,F,H	132954080(+)	`TCTCTG/ACCTCT`	1	--	ng3¹		4		EU EA WA	420
	rs4605911^1,2	A,C,F,H	132954305(+)	`TGTTTC/TCCAAG`	1	--	ng3¹		8		EU EA WA NA	634
	rs9493387^1,2	A,C,F,H	132953412(+)	`GTTGGC/TCACAA`	1	--	ng3¹		11		EU EA WA NA	978
	rs9493388^1,2	A,C,F,H	132953592(+)	`TTAATT/CAGAGA`	1	--	ng3¹		7		EU EA WA NA	542
	rs9493389^1,2	A,C,F,H	132953727(+)	`TATTTC/TTCTTC`	1	--	ng3¹ trp³		8		EU EA WA	782
	rs9493390^1,2	A,F,H	132953741(+)	`TTTAGT/GATTAT`	1	--	ng3¹		4		EU EA WA	398
	rs17061477^1,2	C,F,H	132952963(+)	`TCTGAA/CCCAAG`	1	--	ng3¹		11		NA EU EA WA	980
	rs12208145^1,2	C,F,H	132954004(+)	`AGGTAC/AAATTA`	1	--	ng3¹		7		EU EA WA NA	548
--	rs7745190^1,2	A,C	132951282(+)	`atataC/Tacgta`	1	--	ng5¹		0	--	--	--	--
	rs35839363^1,2	C,F	132951531(-)	`AGACAC/TGCACT`	1	R/C	mis¹		5		NA EU EA WA	468

About this table

HapMap Linkage Disequilibrium images for TAAR5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607405

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for TAAR5 gene:

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)^{2, 3, 4} Lindemann L....Hoener M.C. (2005)
Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. (PubMed id 9464258)^{2, 3, 4} Zeng Z....Li Y. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)³ Liberles S.D. and Buck L.B. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Biogenic Trace Amine-Associated Receptors (TAARS) are encoded in avian genomes: evidence and possible implications. (PubMed id 18296390)¹ Mueller J.C....Kempenaers B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9038	HGNC: 30236	AceView: PNR	Ensembl:ENSG00000135569	euGenes: HUgn9038
ECgene: TAAR5	H-InvDB: TAAR5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TAAR5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAAR5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAAR5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAAR5		Antibodies for TAAR5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TAAR5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAAR5)
	Antibodies (TAAR5)
	Chimera RNAi (TAAR5)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (PNR)
	Antibodies (PNR)

Search OriGene for TAAR5

Search Tocris compounds for TAAR5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAAR5

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TAAR5 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for TAAR5

Summaries
for TAAR5

Genomic Location
for TAAR5

Proteins
for TAAR5

Protein Domains/
Families
for TAAR5

Gene Function
for TAAR5

Pathways & Interactions
for TAAR5

Drugs & Compounds
for TAAR5

Transcripts
for TAAR5

Expression
for TAAR5

Orthologs
for TAAR5

Paralogs
for TAAR5

SNPs/Variants
for TAAR5

Disorders & Mutations
for TAAR5

Medical News
for TAAR5

Publications
for TAAR5

Search for TAAR5

Genome Databases showing TAAR5

Other Databases showing TAAR5

Specialized Databases showing TAAR5

Licensable Technologies
for TAAR5

Services
for TAAR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAAR5 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor TAAR5

Summariesfor TAAR5

Genomic Locationfor TAAR5

Proteinsfor TAAR5

Protein Domains/Familiesfor TAAR5

Gene Functionfor TAAR5

Pathways & Interactionsfor TAAR5

Drugs & Compoundsfor TAAR5

Transcriptsfor TAAR5

Expression for TAAR5

Orthologsfor TAAR5

Paralogsfor TAAR5

SNPs/Variantsfor TAAR5

Disorders & Mutationsfor TAAR5

Medical Newsfor TAAR5

Publicationsfor TAAR5

Search for TAAR5

Genome Databases showing TAAR5

Other Databases showing TAAR5

Specialized Databases showing TAAR5

Licensable Technologiesfor TAAR5

Servicesfor TAAR5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAAR5

Summaries
for TAAR5

Genomic Location
for TAAR5

Proteins
for TAAR5

Protein Domains/
Families
for TAAR5

Gene Function
for TAAR5

Pathways & Interactions
for TAAR5

Drugs & Compounds
for TAAR5

Transcripts
for TAAR5

Expression
for TAAR5

Orthologs
for TAAR5

Paralogs
for TAAR5

SNPs/Variants
for TAAR5

Disorders & Mutations
for TAAR5

Medical News
for TAAR5

Publications
for TAAR5

Licensable Technologies
for TAAR5

Services
for TAAR5