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TAAR3 Gene

pseudogene   GIFtS: 38
GCID: GC06M132930

Trace Amine Associated Receptor 3 (Gene/Pseudogene)

(Previous names: G protein-coupled receptor 57, trace amine associated receptor...)
(Previous symbol: GPR57)
  Search for TAAR3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trace Amine Associated Receptor 3 (Gene/Pseudogene)1 2     TAAR22
GPR571 2 3     TaR-33
G Protein-Coupled Receptor 571     G-Protein Coupled Receptor 573
Trace Amine Associated Receptor 31     hTaar33
GPR582     Trace Amine Receptor 33

External Ids:    HGNC: 45131   Entrez Gene: 92882   Ensembl: ENSG000001790737   UniProtKB: Q9P1P43   

Export aliases for TAAR3 gene to outside databases

Previous GC identifers: GC06M132972 GC06M130504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAAR3 Gene:
TAAR3 (trace amine associated receptor 3 (gene/pseudogene)) is a pseudogene. GO annotations related to this gene include trace-amine receptor activity and G-protein coupled receptor activity.

UniProtKB/Swiss-Prot: TAAR3_HUMAN, Q9P1P4
Function: Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by
isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This
receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity)

Gene Wiki entry for TAAR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TAAR3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TAAR3 promoter sequence
   Search Chromatin IP Primers for TAAR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAAR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23-q24

TAAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAAR3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132930:  view genomic region     (about GC identifiers)

Start:
132,929,364 bp from pter      End:
132,930,441 bp from pter
Size:
1,078 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAAR3_HUMAN, Q9P1P4 (See protein sequence)
Recommended Name: Putative trace amine-associated receptor 3  
Size: 343 amino acids; 39065 Da
Caution: Seems to be a non functional due to its divergence in positions 20 to 45 (due to a frameshift) but does
not seem to be the product of a pseudogene

Explore the universe of human proteins at neXtProt for TAAR3: NX_Q9P1P4

Post-translational modifications: 

  • Glycosylation2 at Asn145
  • Reactome Protein details: Q9P1P4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TAAR: GPCR / Class A : Trace amine associated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TAAR3
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009132 TAAR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9P1P4

    ProtoNet protein and cluster: Q9P1P4

    UniProtKB/Swiss-Prot: TAAR3_HUMAN, Q9P1P4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with TAAR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAAR3_HUMAN, Q9P1P4
    Function: Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by
    isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This
    receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001594trace-amine receptor activity ISS--
    GO:0004930G-protein coupled receptor activity TAS10684976
         
    Find genes that share ontologies with TAAR3           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Taar3):
     no phenotypic analysis 

    Find genes that share phenotypes with TAAR3           About GenesLikeMe

    Animal Models:
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    hsa-mir-335-5p (MIRT019016)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAAR3_HUMAN, Q9P1P4: Cell membrane; Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TAAR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAAR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCR ligand binding0.71
    3Monoamine GPCRs
    Amine ligand-binding receptors0.79
    4GPCRs, Other
    GPCRs, Other
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with TAAR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TAAR3
        GPCRs, Other

    2 Reactome Pathways for TAAR3
        G alpha (s) signalling events
    Amine ligand-binding receptors


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    Interactions:

        Search GeneGlobe Interaction Network for TAAR3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007606sensory perception of chemical stimulus ISS--

    Find genes that share ontologies with TAAR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for TAAR3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466706(uc021zfk.1) ENST00000481759 ENST00000313326
    miRNA
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    6 AceView cDNA sequences:

    CD559544 BG188394 CD559545 CF147791 BG195643 BG212211 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAAR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCAGAAA
    TAAR3 Expression
    About this image

    TAAR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    UniProtKB/Swiss-Prot: TAAR3_HUMAN, Q9P1P4
    Tissue specificity: Not expressed in the pons, thalamus, globus pallidus, caudate, putamen or cerebellum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TAAR3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taar35 trace amine-associated receptor 3   --   10 (11.40 cM) 23949558 


    ENSEMBL Gene Tree for TAAR3 (if available)
    TreeFam Gene Tree for TAAR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAAR3 gene
    11 SIMAP similar genes for TAAR3 using alignment to 1 protein entry:     TAAR3_HUMAN:
    TAAR2    TAAR1    TAAR9    TAAR5    TAAR6    TAAR8
    HTR4    HTR4B    DRD1    ADRB2    HRH2

    Find genes that share paralogs with TAAR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAAR3 (see all 98)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs591369521,2
    C,F--132928872(+) GAATAG/ATTTGT 1 -- ds50013Minor allele frequency- A:0.11WA NA 240
    rs1930184441,2
    --132928925(+) AGGCCA/GCTAGT 1 -- ds50010--------
    rs1486743291,2
    --132928936(+) TGTTAA/GTAGAG 1 -- ds50010--------
    rs122003771,2
    C,F,H--132929016(+) AATGGT/CATCAG 1 -- ds500120Minor allele frequency- C:0.31NS EA NA WA CSA 2346
    rs1433590711,2
    --132929028(+) TAGGAA/GCCAAA 1 -- ds50010--------
    rs1852144531,2
    --132929029(+) AGGAAC/TCAAAG 1 -- ds50010--------
    rs94834831,2
    C,F--132929083(+) CATGTA/GTGTAA 1 -- ds50014Minor allele frequency- G:0.08CSA WA NA 241
    rs122004301,2
    C,F,H--132929084(+) ATGTAC/TGTAAA 1 -- ds500127Minor allele frequency- T:0.43NA NS EA WA CSA 2877
    rs1467647051,2
    --132929130(+) TCTTTC/TGTACA 1 -- ds50010--------
    rs1403792571,2
    --132929131(+) CTTTCA/GTACAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TAAR3 (132929364 - 132930441 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAAR3: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TAAR3
    DNA2.0 Custom Variant and Variant Library Synthesis for TAAR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAAR3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TAAR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of additional members of the G protein- coupled receptor family. (PubMed id 10684976)1, 2, 3, 9 Lee D.K....Marchese A. (Biochim. Biophys. Acta 2000)
    2. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. (PubMed id 19325074)1, 3, 9 Maguire J.J....Davenport A.P. (Pharmacol. Rev. 2009)
    3. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 3 Lindemann L....Hoener M.C. (Genomics 2005)
    4. High species variation within the repertoire of trace amine receptors. (PubMed id 15891052)1, 3 Gloriam D.E....Fredriksson R. (Ann. N. Y. Acad. Sci. 2005)
    5. Discovery of a null mutation in a human trace amine receptor gene. (PubMed id 14559210)1, 3 Vanti W.B....O'Dowd B.F. (Genomics 2003)
    6. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (Genome Biol. 2010)
    7. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (Mol. Biotechnol. 2008)
    8. A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)1 Liberles S.D. and Buck L.B. (Nature 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. A locus for simple pure febrile seizures maps to chromosome 6q22-q24. (PubMed id 12429594)9 Nabbout R....LeGuern E. (Brain 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9288 HGNC: 4513 AceView: GPR57 Ensembl:ENSG00000179073 euGenes: HUgn9288
    ECgene: TAAR3 H-InvDB: TAAR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAAR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAAR3 gene:
    Search GeneIP for patents involving TAAR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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