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Aliases for TAAR3 Gene

Aliases for TAAR3 Gene

  • Trace Amine Associated Receptor 3 (Gene/Pseudogene) 2 3
  • G Protein-Coupled Receptor 57 2 3
  • GPR57 3 4
  • Trace Amine Associated Receptor 2 Pseudogene 3
  • Trace Amine Associated Receptor 3 2
  • G-Protein Coupled Receptor 57 4
  • Trace Amine Receptor 3 4
  • HTaar3 4
  • GPR58 3
  • TAAR2 3
  • TaR-3 4

External Ids for TAAR3 Gene

Previous HGNC Symbols for TAAR3 Gene

  • GPR57

Previous GeneCards Identifiers for TAAR3 Gene

  • GC06M132972
  • GC06M130504
  • GC06M132930

Summaries for TAAR3 Gene

GeneCards Summary for TAAR3 Gene

TAAR3 (Trace Amine Associated Receptor 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity.

UniProtKB/Swiss-Prot for TAAR3 Gene

  • Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).

Gene Wiki entry for TAAR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR3 Gene

Genomics for TAAR3 Gene

Genomic Location for TAAR3 Gene

Start:
132,608,225 bp from pter
End:
132,609,302 bp from pter
Size:
1,078 bases
Orientation:
Minus strand

Genomic View for TAAR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAAR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR3 Gene

No data available for Regulatory Elements for TAAR3 Gene

Proteins for TAAR3 Gene

  • Protein details for TAAR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1P4-TAAR3_HUMAN
    Recommended name:
    Putative trace amine-associated receptor 3
    Protein Accession:
    Q9P1P4
    Secondary Accessions:

    Protein attributes for TAAR3 Gene

    Size:
    343 amino acids
    Molecular mass:
    39065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR3 Gene

Proteomics data for TAAR3 Gene at MOPED

Post-translational modifications for TAAR3 Gene

  • Glycosylation at Asn145
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR3 Gene

Reactome Protein details:

No data available for DME Specific Peptides for TAAR3 Gene

Domains for TAAR3 Gene

Gene Families for TAAR3 Gene

HGNC:
  • TAAR :GPCR / Class A : Trace amine associated receptors
IUPHAR :

Protein Domains for TAAR3 Gene

Suggested Antigen Peptide Sequences for TAAR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1P4

UniProtKB/Swiss-Prot:

TAAR3_HUMAN :
  • Q9P1P4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR3: view

Function for TAAR3 Gene

Molecular function for TAAR3 Gene

UniProtKB/Swiss-Prot Function:
Olfactory receptor activated by several primary trace amines, including isoamylamine. Activated by isoamylamine and cyclohexylamine, but not to the corresponding alcohols, isoamylalcohol and cyclohexanol. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase (By similarity).

Gene Ontology (GO) - Molecular Function for TAAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity ISS --
GO:0004930 G-protein coupled receptor activity TAS 10684976
genes like me logo Genes that share ontologies with TAAR3: view

Phenotypes for TAAR3 Gene

MGI mutant phenotypes for TAAR3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TAAR3: view

Animal Model Products

miRNA for TAAR3 Gene

miRTarBase miRNAs that target TAAR3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAAR3 Gene

Localization for TAAR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TAAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAAR3: view

No data available for Subcellular locations from COMPARTMENTS for TAAR3 Gene

Pathways for TAAR3 Gene

genes like me logo Genes that share pathways with TAAR3: view

Pathways by source for TAAR3 Gene

Interacting Proteins for TAAR3 Gene

Gene Ontology (GO) - Biological Process for TAAR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007606 sensory perception of chemical stimulus ISS --
genes like me logo Genes that share ontologies with TAAR3: view

Transcripts for TAAR3 Gene

mRNA/cDNA for TAAR3 Gene

(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR3 Gene

Trace amine associated receptor 3 (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAAR3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR3 Gene

No ASD Table

Relevant External Links for TAAR3 Gene

GeneLoc Exon Structure for
TAAR3
ECgene alternative splicing isoforms for
TAAR3

Expression for TAAR3 Gene

mRNA expression in normal human tissues for TAAR3 Gene

mRNA differential expression in normal tissues according to GTEx for TAAR3 Gene

This gene is overexpressed in Liver (11.1) and Brain - Hypothalamus (4.9).

SOURCE GeneReport for Unigene cluster for TAAR3 Gene Hs.730091

mRNA Expression by UniProt/SwissProt for TAAR3 Gene

Q9P1P4-TAAR3_HUMAN
Tissue specificity: Not expressed in the pons, thalamus, globus pallidus, caudate, putamen or cerebellum
genes like me logo Genes that share expressions with TAAR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for TAAR3 Gene

Orthologs for TAAR3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TAAR3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Taar3 16
Species with no ortholog for TAAR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TAAR3 Gene

ENSEMBL:
Gene Tree for TAAR3 (if available)
TreeFam:
Gene Tree for TAAR3 (if available)

Paralogs for TAAR3 Gene

Selected SIMAP similar genes for TAAR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAAR3: view

No data available for Paralogs for TAAR3 Gene

Variants for TAAR3 Gene

Sequence variations from dbSNP and Humsavar for TAAR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1081074 -- 132,610,318(-) GGCCT(G/T)CTTTT upstream-variant-2KB
rs1081075 -- 132,610,294(-) AGCAG(A/T)CTCTG upstream-variant-2KB
rs1081076 -- 132,610,220(-) GATGT(A/G)TATTC upstream-variant-2KB
rs1081077 -- 132,610,187(-) GTGAC(A/C)ATTTA upstream-variant-2KB
rs1081078 -- 132,610,169(-) TTTTT(A/G)TTTAT upstream-variant-2KB

Relevant External Links for TAAR3 Gene

HapMap Linkage Disequilibrium report
TAAR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAAR3 Gene

Disorders for TAAR3 Gene

No disorders were found for TAAR3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TAAR3 Gene

Publications for TAAR3 Gene

  1. Cloning and characterization of additional members of the G protein- coupled receptor family. (PMID: 10684976) Lee D.K. … Marchese A. (Biochim. Biophys. Acta 2000) 2 3 4 23
  2. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. (PMID: 19325074) Maguire J.J. … Davenport A.P. (Pharmacol. Rev. 2009) 2 3 23
  3. Discovery of a null mutation in a human trace amine receptor gene. (PMID: 14559210) Vanti W.B. … O'Dowd B.F. (Genomics 2003) 2 3
  4. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3
  5. High species variation within the repertoire of trace amine receptors. (PMID: 15891052) Gloriam D.E. … Fredriksson R. (Ann. N. Y. Acad. Sci. 2005) 2 3

Products for TAAR3 Gene

Sources for TAAR3 Gene

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