TAAR2 Gene
protein-coding GIFtS: 48
GCID: GC06M132939
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|
trace amine associated receptor 2(Previous name: G protein-coupled receptor 58 )
(Previous symbol: GPR58)
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Aliases
for TAAR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trace Amine Associated Receptor 21 2 | | G-Protein Coupled Receptor 582 3 | | GPR581 2 3 5 | | TaR-23 | | G Protein-Coupled Receptor 581 2 | | Trace Amine-Associated Receptor 22 | | Trace Amine Receptor 22 3 | | TaR-23 |
Export aliases for TAAR2 gene to outside databasesPrevious GC identifers: GC06M132981 GC06M130513 |
Summaries
for TAAR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5Function: Orphan receptor
Gene Wiki entry for TAAR2
|
Genomic Views
for TAAR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAAR2 gene promoter:
CHOP-10 POU2F1 POU2F1a Cart-1 C/EBPalpha FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAAR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q24TAAR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M132939: view genomic region
(about GC identifiers)
Start:
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132,938,161 bp from pter |
End:
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132,945,414 bp from pter |
Size:
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7,254 bases |
Orientation:
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minus strand |
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Proteins
for TAAR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5 (See
protein sequence)Recommended Name: Trace amine-associated receptor 2 Size: 351 amino acids; 40134 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5QD02 Q6NWS1 Q6NWS2 Q6NWS3Alternative splicing: 2 isoforms: Q9P1P5-1 Q9P1P5-2 Explore the universe of human proteins at neXtProt for TAAR2: NX_Q9P1P5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P1P5
TAAR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001028252.1 NP_055441.2
ENSEMBL proteins: ENSP00000275191 ENSP00000356908 ENSP00000441263 Reactome Protein details: Q9P1P5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TAAR2 for ontologies About GeneDecksing
TAAR2 Antibody Products:
Assay Products for TAAR2: |
Protein
Domains /
Families
for TAAR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAAR2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P1P5ProtoNet protein and cluster: Q9P1P5 UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TAAR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5Function: Orphan receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TAAR2 (NM_001033080) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
TAS | 15718104 |
TAAR2 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAAR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | GPCRs, Other | | | 4 | Monoamine GPCRs | | | 5 | G beta:gamma signalling through PLC beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TAAR2
5/7 
Reactome Pathways for TAAR2 (see all 7)
1 
Kegg Pathway (Kegg details for TAAR2):
TAAR2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAAR2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 15718104 |
TAAR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAAR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAAR2
Search CenterWatch for drugs/clinical trials and news about TAAR2
|
Transcripts
for TAAR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAAR2 gene (2 alternative transcripts): NM_001033080.1 NM_014626.3 Unigene Cluster for TAAR2: Trace amine associated receptor 2 Hs.272382 [show with all ESTs]Unigene Representative Sequence: AY7034803 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000275191(uc010kfr.1) ENST00000367931 ENST00000537809(uc003qdl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAAR2 (NM_001033080) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAAR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR2 |
Additional cDNA sequence: AY702304.1 AY703480.1 BC067461.1 BC067462.1 BC067463.1 1 DOTS entry: DT.91948795 10 AceView cDNA sequences: CK130266 CD559639 CD559543 CD559638 NM_014626 BC067463 CD559640 CF147778 BC067461 BC067462
GeneLoc Exon Structure
|
Expression
for TAAR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAAR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TAAR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAAR2
SOURCE GeneReport for Unigene cluster: Hs.272382
UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5Tissue specificity: Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex,basal forebrain, midbrain or liver
SABiosciences Expression via Pathway-Focused PCR Array including TAAR2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAAR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR2 |
Orthologs
for TAAR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAAR2 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for TAAR2 (if available)
TreeFam Gene Tree for TAAR2 (if available) |
Paralogs
for TAAR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAAR2 gene
- TAAR62 HTR2A2 HTR62 ADRB12 TAAR82 HRH22 HTR2B2 DRD12
- HTR2C2 TAAR12 ADRB22 HTR42 DRD52 ADRB32 TAAR52
14 SIMAP similar genes for TAAR2 using alignment to 1 protein entry: TAAR2_HUMAN:TAAR3 TAAR1 TAAR5 alpha 1c-adrenoceptor subtype DRD2 HTR5A
TAAR6 TAAR9 TAAR8 HTR4 HTR4B HRH2
ADRB2 ADRA1A
TAAR2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TAAR2
PGOHUM00000243374
|
Genomic Variants
for TAAR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAAR2 (132938161 - 132945414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TAAR2
6 CNVs: 94021 81597 94027 81593 81596 94019 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR2 |
|
Disorders
/ Diseases
for TAAR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAAR2 for disorders About GeneDecksing
OMIM gene information: 604849
OMIM disorders: --
2  diseases for TAAR2: About MalaCardsfebrile seizures seizures
Export disorders for TAAR2 gene to outside databases
|
Publications
for TAAR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAAR2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAAR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 2, 3 Lindemann L....Hoener M.C. (2005)
- Cloning and characterization of additional members of the G protein- coupled receptor family. (PubMed id 10684976)1, 2, 3 Lee D.K....Marchese A. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PubMed id 18240029)1 Luttrell L.M. (2008)
- A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)1 Liberles S.D. and Buck L.B. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Examination of the trace amine-associated receptor 2 (TAAR2). (PubMed id 15993565)9 Bly M. (2005)
- Biogenic Trace Amine-Associated Receptors (TAARS) are encoded in avian genomes: evidence and possible implications. (PubMed id 18296390)9 Mueller J.C....Kempenaers B. (2008)
- A locus for simple pure febrile seizures maps to chromosome 6q22-q24. (PubMed id 12429594)9 Nabbout R....LeGuern E. (2002)
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External Searches for TAAR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAAR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAAR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAAR2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TAAR2 gene:
Search GeneIP for patents involving TAAR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAAR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAAR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAAR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAAR2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAAR2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAAR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAAR2 | | OriGene Custom Protein Services for TAAR2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAAR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAAR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAAR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAAR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAAR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAAR2 |
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 |  |  |  | |
| | | | Search Tocris compounds for TAAR2 |
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 | | | TAAR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR2 |
|  |  |  | | | | ThermoFisher Antibodies for TAAR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR2 |
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