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Aliases for TAAR2 Gene

Aliases for TAAR2 Gene

  • Trace Amine Associated Receptor 2 2 3 5
  • G Protein-Coupled Receptor 58 2 3
  • TaR-2 3 4
  • GPR58 3 4
  • Trace Amine-Associated Receptor 2 3
  • G-Protein Coupled Receptor 58 4
  • Trace Amine Receptor 2 4

External Ids for TAAR2 Gene

Previous HGNC Symbols for TAAR2 Gene

  • GPR58

Previous GeneCards Identifiers for TAAR2 Gene

  • GC06M132981
  • GC06M130513
  • GC06M132939
  • GC06M132617

Summaries for TAAR2 Gene

GeneCards Summary for TAAR2 Gene

TAAR2 (Trace Amine Associated Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR1.

UniProtKB/Swiss-Prot for TAAR2 Gene

  • Orphan receptor.

Gene Wiki entry for TAAR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR2 Gene

Genomics for TAAR2 Gene

Regulatory Elements for TAAR2 Gene

Enhancers for TAAR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F132146 0.8 FANTOM5 ENCODE 2.6 +476.6 476570 1.9 JUND ATF2 CTGF TAAR2 LINC01013 EEF1A1P36
GH06F132614 0.4 Ensembl 0.4 +9.6 9558 0.4 MLLT1 EBF1 TAAR5 VNN1 TAAR2 TAAR3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAAR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAAR2 Gene

132,599,627 bp from pter
132,624,358 bp from pter
24,732 bases
Minus strand

Genomic View for TAAR2 Gene

Genes around TAAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR2 Gene

Proteins for TAAR2 Gene

  • Protein details for TAAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trace amine-associated receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q5QD02
    • Q6NWS1
    • Q6NWS2
    • Q6NWS3

    Protein attributes for TAAR2 Gene

    351 amino acids
    Molecular mass:
    40134 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAAR2 Gene


neXtProt entry for TAAR2 Gene

Post-translational modifications for TAAR2 Gene

  • Glycosylation at Asn 24, Asn 30, and Asn 289
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR2 Gene

Domains & Families for TAAR2 Gene

Gene Families for TAAR2 Gene

Protein Domains for TAAR2 Gene

Suggested Antigen Peptide Sequences for TAAR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR2: view

Function for TAAR2 Gene

Molecular function for TAAR2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10684976
genes like me logo Genes that share ontologies with TAAR2: view
genes like me logo Genes that share phenotypes with TAAR2: view

Animal Model Products

miRNA for TAAR2 Gene

miRTarBase miRNAs that target TAAR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAAR2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAAR2 Gene

Localization for TAAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAAR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IC --
genes like me logo Genes that share ontologies with TAAR2: view

Pathways & Interactions for TAAR2 Gene

genes like me logo Genes that share pathways with TAAR2: view

Pathways by source for TAAR2 Gene

Interacting Proteins for TAAR2 Gene

Gene Ontology (GO) - Biological Process for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with TAAR2: view

No data available for SIGNOR curated interactions for TAAR2 Gene

Transcripts for TAAR2 Gene

mRNA/cDNA for TAAR2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR2 Gene

Trace amine associated receptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAAR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR2 Gene

No ASD Table

Relevant External Links for TAAR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAAR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAAR2 Gene

mRNA differential expression in normal tissues according to GTEx for TAAR2 Gene

This gene is overexpressed in Testis (x53.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAAR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAAR2 Gene:


SOURCE GeneReport for Unigene cluster for TAAR2 Gene:


mRNA Expression by UniProt/SwissProt for TAAR2 Gene:

Tissue specificity: Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain or liver.
genes like me logo Genes that share expression patterns with TAAR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for TAAR2 Gene

Orthologs for TAAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAAR2 35
  • 97 (a)
(Bos Taurus)
Mammalia TAAR2 34 35
  • 89.65 (n)
(Canis familiaris)
Mammalia TAAR2 34
  • 88 (n)
TAAR4 35
  • 49 (a)
(Mus musculus)
Mammalia Taar2 34 16 35
  • 84.48 (n)
(Rattus norvegicus)
Mammalia Taar2 34
  • 84.38 (n)
(Monodelphis domestica)
Mammalia TAAR2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TAAR2 35
  • 82 (a)
(Gallus gallus)
Aves TAAR2 34 35
  • 68.12 (n)
(Anolis carolinensis)
Reptilia TAAR2 35
  • 66 (a)
(Danio rerio)
Actinopterygii taar12j 35
  • 44 (a)
taar13c 35
  • 44 (a)
CU672229.1 35
  • 43 (a)
taar12i 35
  • 43 (a)
taar12e 35
  • 42 (a)
taar12g 35
  • 42 (a)
taar12h 35
  • 42 (a)
taar12c 35
  • 41 (a)
TAAR2 (9 of 11) 35
  • 41 (a)
taar12a 35
  • 39 (a)
taar12b 35
  • 39 (a)
Species where no ortholog for TAAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR2 Gene

Gene Tree for TAAR2 (if available)
Gene Tree for TAAR2 (if available)

Paralogs for TAAR2 Gene

Paralogs for TAAR2 Gene

(14) SIMAP similar genes for TAAR2 Gene using alignment to 1 proteins: Pseudogenes for TAAR2 Gene

genes like me logo Genes that share paralogs with TAAR2: view

Variants for TAAR2 Gene

Sequence variations from dbSNP and Humsavar for TAAR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10583513 -- 132,624,151(+) TTCAC(-/AT)GTTTA intron-variant
rs111234170 -- 132,620,664(+) AAAAG(A/G)TAACT intron-variant
rs111536343 -- 132,621,374(+) AGACC(C/T)GCATG intron-variant
rs111808231 -- 132,617,994(+) GCTTG(A/G)AGTAG reference, missense
rs111850088 -- 132,622,762(+) TACAG(G/T)CGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAAR2 Gene

Variant ID Type Subtype PubMed ID
esv3571395 CNV loss 25503493

Variation tolerance for TAAR2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAAR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAAR2 Gene

Disorders for TAAR2 Gene

Relevant External Links for TAAR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TAAR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAAR2 Gene

Publications for TAAR2 Gene

  1. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3 4 64
  2. Cloning and characterization of additional members of the G protein- coupled receptor family. (PMID: 10684976) Lee D.K. … Marchese A. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. (PMID: 23315425) Babusyte A. … Krautwurst D. (J. Leukoc. Biol. 2013) 3 64

Products for TAAR2 Gene

Sources for TAAR2 Gene

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