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Aliases for TAAR2 Gene

Aliases for TAAR2 Gene

  • Trace Amine Associated Receptor 2 (Gene/Pseudogene) 2 3 5
  • G Protein-Coupled Receptor 58 2 3
  • TaR-2 3 4
  • GPR58 3 4
  • Trace Amine-Associated Receptor 2 3
  • G-Protein Coupled Receptor 58 4
  • Trace Amine Receptor 2 4

External Ids for TAAR2 Gene

Previous HGNC Symbols for TAAR2 Gene

  • GPR58

Previous GeneCards Identifiers for TAAR2 Gene

  • GC06M132981
  • GC06M130513
  • GC06M132939
  • GC06M132617

Summaries for TAAR2 Gene

GeneCards Summary for TAAR2 Gene

TAAR2 (Trace Amine Associated Receptor 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with TAAR2 include Generalized Epilepsy With Febrile Seizures Plus. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR1.

UniProtKB/Swiss-Prot for TAAR2 Gene

  • Orphan receptor.

Gene Wiki entry for TAAR2 Gene

Additional gene information for TAAR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR2 Gene

Genomics for TAAR2 Gene

GeneHancer (GH) Regulatory Elements for TAAR2 Gene

Promoters and enhancers for TAAR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I132624 Promoter 0.5 EPDnew 550.8 0.0 -35 0.1 TAAR2 TAAR1
GH06I132146 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +476.6 476570 1.9 ATF7 ATF2 CTGF TAAR2 LINC01013 EEF1A1P36 GC06M132077
GH06I132611 Enhancer 0.6 ENCODE 0.4 +11.8 11773 1.9 GATAD2A FOXA2 FOXA3 NR2F1 NR2F2 RARA HNF1A CEBPA HNF4A NR2F6 TAAR5 VNN2 ENPP3 TAAR3P TAAR2
GH06I132607 Enhancer 0.5 ENCODE 0.4 +16.5 16518 1.7 JUND RXRA MAX HNF4A ZBTB33 REST YY1 TAAR3P SNORA33 TAAR4P TAAR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAAR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAAR2 gene promoter:

Genomic Locations for TAAR2 Gene

Genomic Locations for TAAR2 Gene
chr6:132,599,627-132,624,358
(GRCh38/hg38)
Size:
24,732 bases
Orientation:
Minus strand
chr6:132,938,161-132,945,414
(GRCh37/hg19)

Genomic View for TAAR2 Gene

Genes around TAAR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR2 Gene

Proteins for TAAR2 Gene

  • Protein details for TAAR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1P5-TAAR2_HUMAN
    Recommended name:
    Trace amine-associated receptor 2
    Protein Accession:
    Q9P1P5
    Secondary Accessions:
    • Q5QD02
    • Q6NWS1
    • Q6NWS2
    • Q6NWS3

    Protein attributes for TAAR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    40134 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAAR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAAR2 Gene

Post-translational modifications for TAAR2 Gene

  • Glycosylation at posLast=2424, isoforms=30, and isoforms=2289

Other Protein References for TAAR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR2 Gene

Domains & Families for TAAR2 Gene

Gene Families for TAAR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TAAR2 Gene

Suggested Antigen Peptide Sequences for TAAR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1P5

UniProtKB/Swiss-Prot:

TAAR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR2: view

Function for TAAR2 Gene

Molecular function for TAAR2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for TAAR2 Gene

Gene Ontology (GO) - Molecular Function for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10684976
genes like me logo Genes that share ontologies with TAAR2: view
genes like me logo Genes that share phenotypes with TAAR2: view

miRNA for TAAR2 Gene

miRTarBase miRNAs that target TAAR2

Clone Products

  • Addgene plasmids for TAAR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAAR2 Gene

Localization for TAAR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAAR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IC,IEA --
genes like me logo Genes that share ontologies with TAAR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAAR2 Gene

Pathways & Interactions for TAAR2 Gene

genes like me logo Genes that share pathways with TAAR2: view

Pathways by source for TAAR2 Gene

Interacting Proteins for TAAR2 Gene

Gene Ontology (GO) - Biological Process for TAAR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with TAAR2: view

No data available for SIGNOR curated interactions for TAAR2 Gene

Drugs & Compounds for TAAR2 Gene

No Compound Related Data Available

Transcripts for TAAR2 Gene

mRNA/cDNA for TAAR2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR2 Gene

Trace amine associated receptor 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for TAAR2

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR2 Gene

No ASD Table

Relevant External Links for TAAR2 Gene

GeneLoc Exon Structure for
TAAR2
ECgene alternative splicing isoforms for
TAAR2

Expression for TAAR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAAR2 Gene

mRNA differential expression in normal tissues according to GTEx for TAAR2 Gene

This gene is overexpressed in Testis (x53.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAAR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAAR2 Gene:

TAAR2

SOURCE GeneReport for Unigene cluster for TAAR2 Gene:

Hs.272382

mRNA Expression by UniProt/SwissProt for TAAR2 Gene:

Q9P1P5-TAAR2_HUMAN
Tissue specificity: Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate, putamen, frontal cortex, basal forebrain, midbrain or liver.
genes like me logo Genes that share expression patterns with TAAR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAAR2 Gene

Orthologs for TAAR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAAR2 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAAR2 33 34
  • 89.65 (n)
dog
(Canis familiaris)
Mammalia TAAR2 33
  • 88 (n)
TAAR4 34
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taar2 33 16 34
  • 84.48 (n)
rat
(Rattus norvegicus)
Mammalia Taar2 33
  • 84.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TAAR2 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAAR2 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAAR2 33 34
  • 68.12 (n)
lizard
(Anolis carolinensis)
Reptilia TAAR2 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii taar12j 34
  • 44 (a)
OneToMany
taar13c 34
  • 44 (a)
OneToMany
CU672229.1 34
  • 43 (a)
OneToMany
taar12i 34
  • 43 (a)
OneToMany
taar12e 34
  • 42 (a)
OneToMany
taar12g 34
  • 42 (a)
OneToMany
taar12h 34
  • 42 (a)
OneToMany
taar12c 34
  • 41 (a)
OneToMany
TAAR2 (9 of 11) 34
  • 41 (a)
OneToMany
taar12a 34
  • 39 (a)
OneToMany
taar12b 34
  • 39 (a)
OneToMany
Species where no ortholog for TAAR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR2 Gene

ENSEMBL:
Gene Tree for TAAR2 (if available)
TreeFam:
Gene Tree for TAAR2 (if available)

Paralogs for TAAR2 Gene

Paralogs for TAAR2 Gene

(14) SIMAP similar genes for TAAR2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAAR2 Gene

genes like me logo Genes that share paralogs with TAAR2: view

Variants for TAAR2 Gene

Sequence variations from dbSNP and Humsavar for TAAR2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000013661 -- 132,618,962(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000263646 -- 132,619,737(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000496450 -- 132,621,479(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000518208 -- 132,625,554(-) C/A upstream_transcript_variant
rs1000603884 -- 132,623,826(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAAR2 Gene

Variant ID Type Subtype PubMed ID
esv3571395 CNV loss 25503493

Variation tolerance for TAAR2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAAR2 Gene

Human Gene Mutation Database (HGMD)
TAAR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAAR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAAR2 Gene

Disorders for TAAR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAAR2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
generalized epilepsy with febrile seizures plus
  • gefs+
- elite association - COSMIC cancer census association via MalaCards
Search TAAR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TAAR2

genes like me logo Genes that share disorders with TAAR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAAR2 Gene

Publications for TAAR2 Gene

  1. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L … Hoener MC (Genomics 2005) 2 3 4 58
  2. Cloning and characterization of additional members of the G protein-coupled receptor family. (PMID: 10684976) Lee DK … Marchese A (Biochimica et biophysica acta 2000) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. (PMID: 23315425) Babusyte A … Krautwurst D (Journal of leukocyte biology 2013) 3 58

Products for TAAR2 Gene

Sources for TAAR2 Gene

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