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TAAR2 Gene

protein-coding   GIFtS: 49

GC06M132981
trace amine associated receptor 2
(Previous name: G protein-coupled receptor 58 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR58)
Services    

Aliases &
Descriptions
for TAAR2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
GPR58 2, 3, 5
Descriptions
G protein-coupled receptor 58 1, 2
G-protein coupled receptor 58 3
trace amine associated receptor 2 2
External Ids
HGNC: 45141
Entrez Gene: 92872
UniProtKB: Q9P1P53
Ensembl: ENSG000001463787
Search outside databases for aliases for TAAR2 gene

Summaries
for TAAR2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5
Function: Orphan receptor

Gene Wiki entry for TAAR2

Genomic Location
for TAAR2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAAR2 gene  

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q24

TAAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132981:     (about GC identifiers)

Start:
 132,979,982 bp from pter
End:
 132,987,107 bp from pter
Size:
 7,126 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  

Proteins
for TAAR2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5 (See protein sequence)
Recommended Name: Trace amine-associated receptor 2  
Size: 351 amino acids; 40134 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5QD02 Q6NWS1 Q6NWS2 Q6NWS3
Alternative splicing: 2 isoforms:  Q9P1P5-1   Q9P1P5-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001028252.1  NP_055441.2  


ENSEMBL proteins: 
ENSP00000356908 ENSP00000275191 


Human Recombinant Proteins 
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Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GPCR GPR58)
Human Recombinant Proteins from Abnova (TAAR2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for TAAR2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Antibodies from Abcam (GPCR GPR58), each with their AbpromiseSM
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Novus Biologicals Antibodies for TAAR2

Assays for TAAR2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for TAAR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR009132 Trace_amine_rcpt
 IPR000276 7TM_GPCR_Rhodpsn


   GeneDecks  TAAR2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9P1P5

ProtoNet protein and cluster: Q9P1P5

UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5
Similarity: Belongs to the G-protein coupled receptor 1 family

Gene Function
for TAAR2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (TAAR2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAAR2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001033080

              Applied Biosystems Silencer® siRNAs for TAAR2

              Sigma-Aldrich siRNA and siRNA Panels for TAAR2  
                     Sigma-Aldrich shRNA Panels and shRNA for TAAR2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001033080
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001033080
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001033080 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001033080

UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5
Function: Orphan receptor

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity TAS10684976
About this table

Pathways & Interactions
for TAAR2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Kegg Pathway  (Kegg details for TAAR2):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  TAAR2 for the pathways selected above  
About GeneDecksing

5 Interacting proteins for TAAR2 (ENSP000003569083) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TAAR8ENSP000002752003STRING (score=.909)
TAAR5ENSP000002580343STRING (score=.907)
TAAR6ENSP000002751983STRING (score=.905)
TAAR1ENSP000002752163STRING (score=.904)
--ENSP000003393233STRING (score=.905)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
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Drugs & Compounds
for TAAR2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAAR2

Transcripts
for TAAR2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (TAAR2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAAR2)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001033080

              Sigma-Aldrich siRNA and siRNA Panels for TAAR2  
                     Sigma-Aldrich shRNA Panels and shRNA for TAAR2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001033080  NM_014626  

REFSEQ mRNAs for TAAR2 gene (2 alternative transcripts): 

NM_001033080.1   NM_014626.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001033080  NM_014626  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001033080
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001033080
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001033080 

Additional cDNA sequence: 

AY702304.1 AY703480.1 BC067461.1 BC067462.1 BC067463.1 

1 DOTS entry:

DT.91948795 

10 AceView cDNA sequences:

CK130266 BC067463 NM_014626 BC067462 CF147778 CD559638 CD559639 BC067461 
CD559640 CD559543 

highest scoring ESTs for TAAR2:

AY703480 BC067461 BC067462 BC067463 CD559543 CD559638 CD559639 CD559640 CF147778 CK130266 

Unigene Cluster for TAAR2:

Trace amine associated receptor 2
Hs.272382  [show with all ESTs]
Unigene Representative Sequence: AY703480


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000367931  ENST00000275191  

Expression
for TAAR2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAAR2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TAAR2

1 / 2 / 3

2 probe-sets matching TAAR2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

221394_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014626 0.60 1.00 0.82 1

221394_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.272382

UniProtKB/Swiss-Prot: TAAR2_HUMAN, Q9P1P5
Tissue specificity: Not expressed in the pons, thalamus, hypothalamus, hippocampus, caudate,
putamen, frontal cortex, basal forebrain, midbrain or liver

Orthologs
for TAAR2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for TAAR2 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
cow
(Bos taurus)		 TAAR21   -- trace amine associated receptor 2 88.59(n)
88.29(a)		 785719  XM_001253652.1  XP_001253653.1 
rat
(Rattus norvegicus)		 Taar21   -- trace amine-associated receptor 2 84.38(n)
88.36(a)		 294121  NM_001008512.1  NP_001008512.1 
mouse
(Mus musculus)		 Taar21, 5 105
 trace amine-associated receptor 21, 5 84.48(n)1
88.36(a)1		 2095121  NM_001007266.11  NP_001007267.11 
 AY2555895  AY7023265  (see all 7)
About this table        Species with no ortholog for TAAR2

ENSEMBL Gene Tree for TAAR2

Paralogs
for TAAR2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for TAAR2 gene
TAAR12  

SNPs/Variants
for TAAR2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/82 NCBI SNPs in TAAR2 are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 84)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs81926461,2
A,C,F,H132980535(+) CCGACC/TAACAT 2 W/X non116Minor allele frequency- N:0.00EU EA WA NA 1468
rs69394701,2
A,C,F,H132989085(+) aacatC/Ggcaag 1 -- ng3111Minor allele frequency- G:0.21EU EA WA NA 980
rs45433951,2
A,C,F,H132989071(+) atgttG/Aaggcc 1 -- ng314Minor allele frequency- A:0.44EU EA WA 418
rs93213571,2
A,F,H132987722(+) ATATGA/TAAGTA 1 -- ng314Minor allele frequency- T:0.02EU EA WA 388
rs43807671,2
C,F,H132988415(+) AGTCCC/TCAGAG 1 -- ng318Minor allele frequency- N:0.00EA NA EU WA 612
rs94834881,2
F,H132988064(+) aaattA/TgcTCA 1 -- ng314Minor allele frequency- T:0.19EU EA WA 418
--
rs131957811,2
A132987514(+) tcaagC/Tgatcc 1 -- ng310--------
rs81926471,2
C,F,H132980764(+) TCCCAG/AGAGGA 2 L/L syn1 ese37Minor allele frequency- A:0.04EU EA WA NA 562
rs93890121,2
A,C,F,H132983309(+) AACCAA/GTTCTT 1 -- int18Minor allele frequency- G:0.48EU EA WA NA 630
rs77694531,2
A,C,F,H132982793(+) ACACCG/ACAGAG 1 -- int14Minor allele frequency- A:0.21EU EA WA 420
About this table

HapMap Linkage Disequilibrium images for TAAR2 (up to first 250kb)

Disorders & Mutations
for TAAR2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 604849

Medical News
for TAAR2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for TAAR2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for TAAR2 gene:

Search for TAAR2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TAAR2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 9287 HGNC: 4514 AceView: GPR58 Ensembl:ENSG00000146378 euGenes: HUgn9287
ECgene: TAAR2 H-InvDB: TAAR2

Other Databases showing TAAR2

(According to HUGE)
About This Section

   --

Specialized Databases showing TAAR2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for TAAR2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for TAAR2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TAAR2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAAR2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for TAAR2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for TAAR2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(GPCR GPR58)
 Antibodies (GPCR GPR58)
 Search OriGene for TAAR2
 Search Tocris compounds for TAAR2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for TAAR2

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