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Aliases for TAAR1 Gene

Aliases for TAAR1 Gene

  • Trace Amine Associated Receptor 1 2 3
  • Trace Amine Receptor 1 2 3 4
  • TA1 3 4 6
  • TaR-1 3 4
  • TRAR1 3 4
  • TAR1 3 4
  • Trace Amine-Associated Receptor 1 3

External Ids for TAAR1 Gene

Previous Symbols for TAAR1 Gene

  • TRAR1

Summaries for TAAR1 Gene

Entrez Gene Summary for TAAR1 Gene

  • TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001 [PubMed 11723224]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TAAR1 Gene

TAAR1 (Trace Amine Associated Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for TAAR1 Gene

  • Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Gene Wiki entry for TAAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR1 Gene

Genomics for TAAR1 Gene

Genomic Location for TAAR1 Gene

Start:
132,644,984 bp from pter
End:
132,646,003 bp from pter
Size:
1,020 bases
Orientation:
Minus strand

Genomic View for TAAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR1 Gene

Regulatory Elements for TAAR1 Gene

Proteins for TAAR1 Gene

  • Protein details for TAAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RJ0-TAAR1_HUMAN
    Recommended name:
    Trace amine-associated receptor 1
    Protein Accession:
    Q96RJ0
    Secondary Accessions:
    • Q2M1W5
    • Q3MIH8
    • Q5VUQ1

    Protein attributes for TAAR1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR1 Gene

Proteomics data for TAAR1 Gene at MOPED

Post-translational modifications for TAAR1 Gene

Other Protein References for TAAR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR1 Gene

Domains for TAAR1 Gene

Gene Families for TAAR1 Gene

HGNC:
  • TAAR :GPCR / Class A : Trace amine associated receptors
IUPHAR :

Protein Domains for TAAR1 Gene

UniProtKB/Swiss-Prot:

TAAR1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96RJ0
genes like me logo Genes that share domains with TAAR1: view

Function for TAAR1 Gene

Molecular function for TAAR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Gene Ontology (GO) - Molecular Function for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 15718104
GO:0008227 G-protein coupled amine receptor activity --
genes like me logo Genes that share ontologies with TAAR1: view
genes like me logo Genes that share phenotypes with TAAR1: view

Animal Models for TAAR1 Gene

MGI Knock Outs for TAAR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TAAR1 Gene

Localization for TAAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAAR1 Gene COMPARTMENTS Subcellular localization image for TAAR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IC 15718104
genes like me logo Genes that share ontologies with TAAR1: view

Pathways for TAAR1 Gene

genes like me logo Genes that share pathways with TAAR1: view

Pathways by source for TAAR1 Gene

Interacting Proteins for TAAR1 Gene

Gene Ontology (GO) - Biological Process for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IDA 11723224
GO:0007186 G-protein coupled receptor signaling pathway TAS 15718104
GO:0007606 sensory perception of chemical stimulus IBA --
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TAAR1: view

Compounds for TAAR1 Gene

(2) HMDB Compounds for TAAR1 Gene

Compound Synonyms Cas Number PubMed IDs
Epinephrine
  • (-)-(R)-Epinephrine
51-43-4
Tyramine
  • 2-(4'-Hydroxyphenyl)ethylamine
51-67-2

(4) Drugbank Compounds for TAAR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amphetamine
  • (+/-)-Benzedrine
300-62-9 target agonist
Dextroamphetamine
  • (+)-(S)-amphetamine
51-64-9 target agonist
Methamphetamine
  • (+ )-methylamphetamine
537-46-2 target agonist
Propylhexedrine
3595-11-7 target agonist

(8) IUPHAR Ligand for TAAR1 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]tyramine Agonist Full agonist 7.7
RO5166017 Agonist Full agonist 7.3
beta-phenylethylamine Agonist Full agonist 7
dextroamphetamine Agonist Full agonist 6.9
tyramine Agonist Full agonist 6.7
R(-)amphetamine Agonist Full agonist 6.6
octopamine Agonist Full agonist 5.8
EPPTB Antagonist Inverse agonist 5.1

(6) Novoseek inferred chemical compound relationships for TAAR1 Gene

Compound -log(P) Hits PubMed IDs
beta-phenylethylamine 90 4
tyramine 83.6 2
amine 70.7 11
amphetamine 65.7 5
methamphetamine 60.9 6
genes like me logo Genes that share compounds with TAAR1: view

Transcripts for TAAR1 Gene

mRNA/cDNA for TAAR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR1 Gene

Trace amine associated receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR1 Gene

No ASD Table

Relevant External Links for TAAR1 Gene

GeneLoc Exon Structure for
TAAR1
ECgene alternative splicing isoforms for
TAAR1

Expression for TAAR1 Gene

mRNA expression in normal human tissues for TAAR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAAR1 Gene

SOURCE GeneReport for Unigene cluster for TAAR1 Gene Hs.375030

mRNA Expression by UniProt/SwissProt for TAAR1 Gene

Q96RJ0-TAAR1_HUMAN
Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen
genes like me logo Genes that share expressions with TAAR1: view

Orthologs for TAAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAAR1 36
  • 99.21 (n)
  • 98.82 (a)
TAAR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAAR1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taar1 36
  • 78.92 (n)
  • 75.9 (a)
Taar1 16
Taar1 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAAR1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAAR1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taar1 36
  • 79.12 (n)
  • 78.61 (a)
chicken
(Gallus gallus)
Aves TAAR1 36
  • 70.18 (n)
  • 70.18 (a)
TAAR1 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAAR1 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taar1 36
  • 67.97 (n)
  • 65.47 (a)
zebrafish
(Danio rerio)
Actinopterygii TAAR1 (17 of 92) 37
  • 35 (a)
OneToMany
TAAR1 (19 of 92) 37
  • 34 (a)
OneToMany
TAAR1 (21 of 92) 37
  • 34 (a)
OneToMany
TAAR1 (22 of 92) 37
  • 46 (a)
OneToMany
TAAR1 (32 of 92) 37
  • 33 (a)
OneToMany
TAAR1 (33 of 92) 37
  • 44 (a)
OneToMany
TAAR1 (42 of 92) 37
  • 33 (a)
OneToMany
TAAR1 (44 of 92) 37
  • 35 (a)
OneToMany
TAAR1 (55 of 92) 37
  • 33 (a)
OneToMany
TAAR1 (62 of 92) 37
  • 35 (a)
OneToMany
TAAR1 (64 of 92) 37
  • 35 (a)
OneToMany
TAAR1 (7 of 92) 37
  • 32 (a)
OneToMany
TAAR1 (73 of 92) 37
  • 35 (a)
OneToMany
TAAR1 (74 of 92) 37
  • 33 (a)
OneToMany
TAAR1 (75 of 92) 37
  • 34 (a)
OneToMany
taar10 37
  • 46 (a)
OneToMany
taar10a 37
  • 47 (a)
OneToMany
taar10b 37
  • 49 (a)
OneToMany
taar10c 37
  • 47 (a)
OneToMany
taar10d 37
  • 48 (a)
OneToMany
taar11 37
  • 45 (a)
OneToMany
taar14a 37
  • 33 (a)
OneToMany
taar14d 37
  • 33 (a)
OneToMany
taar14e 37
  • 33 (a)
OneToMany
taar14f 37
  • 33 (a)
OneToMany
taar14g 37
  • 32 (a)
OneToMany
taar14h 37
  • 33 (a)
OneToMany
taar14i 37
  • 34 (a)
OneToMany
taar14j 37
  • 30 (a)
OneToMany
taar14l 37
  • 34 (a)
OneToMany
taar15 37
  • 34 (a)
OneToMany
taar16a 37
  • 34 (a)
OneToMany
taar16b 37
  • 37 (a)
OneToMany
taar16f 37
  • 32 (a)
OneToMany
taar16g 37
  • 32 (a)
OneToMany
taar17a 37
  • 32 (a)
OneToMany
taar18a 37
  • 34 (a)
OneToMany
taar18b 37
  • 34 (a)
OneToMany
taar18c 37
  • 23 (a)
OneToMany
taar18d 37
  • 32 (a)
OneToMany
taar18e 37
  • 33 (a)
OneToMany
taar18f 37
  • 32 (a)
OneToMany
taar18g 37
  • 33 (a)
OneToMany
taar18h 37
  • 34 (a)
OneToMany
taar18i 37
  • 33 (a)
OneToMany
taar18j 37
  • 33 (a)
OneToMany
taar19a 37
  • 34 (a)
OneToMany
taar19b 37
  • 33 (a)
OneToMany
taar19c 37
  • 35 (a)
OneToMany
taar19d 37
  • 34 (a)
OneToMany
taar19e 37
  • 35 (a)
OneToMany
taar19f 37
  • 34 (a)
OneToMany
taar19g 37
  • 35 (a)
OneToMany
taar19h 37
  • 35 (a)
OneToMany
taar19i 37
  • 36 (a)
OneToMany
taar19j 37
  • 33 (a)
OneToMany
taar19k 37
  • 34 (a)
OneToMany
taar19l 37
  • 32 (a)
OneToMany
taar19m 37
  • 34 (a)
OneToMany
taar19n 37
  • 35 (a)
OneToMany
taar19o 37
  • 35 (a)
OneToMany
taar19p 37
  • 35 (a)
OneToMany
taar19q 37
  • 34 (a)
OneToMany
taar19s 37
  • 35 (a)
OneToMany
taar19t 37
  • 35 (a)
OneToMany
taar19u 37
  • 33 (a)
OneToMany
taar1b 36
  • 56.9 (n)
  • 48.34 (a)
taar1b 37
  • 48 (a)
OneToMany
taar20a 37
  • 34 (a)
OneToMany
taar20a1 37
  • 34 (a)
OneToMany
taar20b 37
  • 35 (a)
OneToMany
taar20b1 37
  • 34 (a)
OneToMany
taar20c 37
  • 33 (a)
OneToMany
taar20c1 37
  • 34 (a)
OneToMany
taar20d1 37
  • 35 (a)
OneToMany
taar20f 37
  • 33 (a)
OneToMany
taar20g 37
  • 34 (a)
OneToMany
taar20h 37
  • 32 (a)
OneToMany
taar20i 37
  • 32 (a)
OneToMany
taar20j 37
  • 34 (a)
OneToMany
taar20l 37
  • 35 (a)
OneToMany
taar20m 37
  • 32 (a)
OneToMany
taar20n 37
  • 34 (a)
OneToMany
taar20o 37
  • 34 (a)
OneToMany
taar20p 37
  • 34 (a)
OneToMany
taar20q 37
  • 34 (a)
OneToMany
taar20r 37
  • 33 (a)
OneToMany
taar20t 37
  • 36 (a)
OneToMany
taar20u 37
  • 33 (a)
OneToMany
taar20w 37
  • 35 (a)
OneToMany
taar20x 37
  • 36 (a)
OneToMany
taar20z 37
  • 34 (a)
OneToMany
taar32 37
  • 35 (a)
OneToMany
Species with no ortholog for TAAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR1 Gene

ENSEMBL:
Gene Tree for TAAR1 (if available)
TreeFam:
Gene Tree for TAAR1 (if available)

Paralogs for TAAR1 Gene

Paralogs for TAAR1 Gene

Selected SIMAP similar genes for TAAR1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAAR1 Gene

genes like me logo Genes that share paralogs with TAAR1: view

Variants for TAAR1 Gene

Sequence variations from dbSNP and Humsavar for TAAR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs4897595 -- 132,646,232(+) GAAGG(A/G)ACTTT upstream-variant-2KB
rs6926857 - 132,645,250(+) CAATG(C/T)CTTCA reference, missense
rs8192617 -- 132,646,161(-) AATTG(C/T)CAATG upstream-variant-2KB
rs8192618 - 132,645,937(-) ATGTC(C/T)GTGCT reference, missense
rs8192619 -- 132,645,209(-) TGGTG(C/T)CCTTT reference, synonymous-codon

Relevant External Links for TAAR1 Gene

HapMap Linkage Disequilibrium report
TAAR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for TAAR1 Gene

Disorders for TAAR1 Gene

(1) University of Copenhagen DISEASES for TAAR1 Gene

genes like me logo Genes that share disorders with TAAR1: view

No data available for UniProtKB/Swiss-Prot for TAAR1 Gene

Publications for TAAR1 Gene

  1. Trace amines: identification of a family of mammalian G protein- coupled receptors. (PMID: 11459929) Borowsky B. … Gerald C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 25
  2. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. (PMID: 11723224) Bunzow J.R. … Grandy D.K. (Mol. Pharmacol. 2001) 3 4

Products for TAAR1 Gene

Sources for TAAR1 Gene

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