Aliases for TAAR1 Gene
External Ids for TAAR1 Gene
Previous HGNC Symbols for TAAR1 Gene
Previous GeneCards Identifiers for TAAR1 Gene
TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001 [PubMed 11723224]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TAAR1 Gene
TAAR1 (Trace Amine Associated Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for TAAR1 Gene
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Thetrace amine 1 (TA1) receptor (also known as the trace amine-associated receptor 1, TAAR1)is a class A GPCR that is activated by endogenous trace amines. To date, the TA1receptor is the only trace amine-associated receptor that has been de-orphaned.