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Aliases for TAAR1 Gene

Aliases for TAAR1 Gene

  • Trace Amine Associated Receptor 1 2 3 5
  • Trace Amine Receptor 1 2 3 4
  • TRAR1 3 4
  • TAR1 3 4
  • TA1 3 4
  • Trace Amine-Associated Receptor 1 3
  • TaR-1 4

External Ids for TAAR1 Gene

Previous HGNC Symbols for TAAR1 Gene

  • TRAR1

Previous GeneCards Identifiers for TAAR1 Gene

  • GC06M133008
  • GC06M130541
  • GC06M132966

Summaries for TAAR1 Gene

Entrez Gene Summary for TAAR1 Gene

  • The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

GeneCards Summary for TAAR1 Gene

TAAR1 (Trace Amine Associated Receptor 1) is a Protein Coding gene. Diseases associated with TAAR1 include Superficial Urinary Bladder Cancer and Paralytic Ileus. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR2.

UniProtKB/Swiss-Prot for TAAR1 Gene

  • Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Tocris Summary for TAAR1 Gene

  • The trace amine 1 (TA1) receptor (also known as the trace amine-associated receptor 1, TAAR1) is a class A GPCR that is activated by endogenous trace amines. To date, the TA1 receptor is the only trace amine-associated receptor that has been de-orphaned.

Gene Wiki entry for TAAR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAAR1 Gene

Genomics for TAAR1 Gene

Regulatory Elements for TAAR1 Gene

Enhancers for TAAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TAAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAAR1 Gene

Chromosome:
6
Start:
132,644,984 bp from pter
End:
132,646,003 bp from pter
Size:
1,020 bases
Orientation:
Minus strand

Genomic View for TAAR1 Gene

Genes around TAAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAAR1 Gene

Proteins for TAAR1 Gene

  • Protein details for TAAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RJ0-TAAR1_HUMAN
    Recommended name:
    Trace amine-associated receptor 1
    Protein Accession:
    Q96RJ0
    Secondary Accessions:
    • Q2M1W5
    • Q3MIH8
    • Q5VUQ1

    Protein attributes for TAAR1 Gene

    Size:
    339 amino acids
    Molecular mass:
    39092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAAR1 Gene

Post-translational modifications for TAAR1 Gene

  • Glycosylation at Asn 10 and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for TAAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAAR1 Gene

Domains & Families for TAAR1 Gene

Gene Families for TAAR1 Gene

Protein Domains for TAAR1 Gene

Suggested Antigen Peptide Sequences for TAAR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RJ0

UniProtKB/Swiss-Prot:

TAAR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TAAR1: view

Function for TAAR1 Gene

Molecular function for TAAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Gene Ontology (GO) - Molecular Function for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 trace-amine receptor activity IBA --
GO:0004930 G-protein coupled receptor activity TAS 15718104
GO:0008227 G-protein coupled amine receptor activity IEA --
genes like me logo Genes that share ontologies with TAAR1: view
genes like me logo Genes that share phenotypes with TAAR1: view

Animal Models for TAAR1 Gene

MGI Knock Outs for TAAR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAAR1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAAR1 Gene

Localization for TAAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAAR1 Gene COMPARTMENTS Subcellular localization image for TAAR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAAR1: view

Pathways & Interactions for TAAR1 Gene

genes like me logo Genes that share pathways with TAAR1: view

Interacting Proteins for TAAR1 Gene

Gene Ontology (GO) - Biological Process for TAAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IDA 11723224
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with TAAR1: view

No data available for SIGNOR curated interactions for TAAR1 Gene

Drugs & Compounds for TAAR1 Gene

(15) Drugs for TAAR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amphetamine Approved, Illicit Pharma antagonist, Target, agonist 105
Methamphetamine Approved, Illicit Pharma antagonist, Target, agonist 216
Dextroamphetamine Approved, Illicit Pharma Full agonist, Agonist, Target, agonist 68
Propylhexedrine Approved Pharma Target, agonist 0
Epinephrine Approved, Vet_approved Pharma 886

(3) Additional Compounds for TAAR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-phenylethylamine
Full agonist, Agonist
Ractopamine hydrochloride
90274-24-1

(2) Tocris Compounds for TAAR1 Gene

Compound Action Cas Number
EPPTB Trace amine 1 (TA1) receptor antagonist/inverse agonist 1110781-88-8
Ractopamine hydrochloride Trace amine 1 (TA1) receptor agonist 90274-24-1
genes like me logo Genes that share compounds with TAAR1: view

Transcripts for TAAR1 Gene

mRNA/cDNA for TAAR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAAR1 Gene

Trace amine associated receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAAR1 Gene

No ASD Table

Relevant External Links for TAAR1 Gene

GeneLoc Exon Structure for
TAAR1
ECgene alternative splicing isoforms for
TAAR1

Expression for TAAR1 Gene

mRNA expression in normal human tissues for TAAR1 Gene

Protein differential expression in normal tissues from HIPED for TAAR1 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAAR1 Gene



Protein tissue co-expression partners for TAAR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAAR1 Gene:

TAAR1

SOURCE GeneReport for Unigene cluster for TAAR1 Gene:

Hs.375030

mRNA Expression by UniProt/SwissProt for TAAR1 Gene:

Q96RJ0-TAAR1_HUMAN
Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen.
genes like me logo Genes that share expression patterns with TAAR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAAR1 Gene

Orthologs for TAAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAAR1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Taar1 34
  • 78.92 (n)
  • 75.9 (a)
Taar1 16
Taar1 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAAR1 34
  • 99.21 (n)
  • 98.82 (a)
TAAR1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taar1 34
  • 79.12 (n)
  • 78.61 (a)
cow
(Bos Taurus)
Mammalia TAAR1 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAAR1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAAR1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAAR1 34
  • 70.18 (n)
  • 70.18 (a)
TAAR1 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAAR1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taar1 34
  • 67.97 (n)
  • 65.47 (a)
zebrafish
(Danio rerio)
Actinopterygii taar1b 34
  • 56.9 (n)
  • 48.34 (a)
TAAR1 (17 of 92) 35
  • 35 (a)
OneToMany
TAAR1 (19 of 92) 35
  • 34 (a)
OneToMany
TAAR1 (21 of 92) 35
  • 34 (a)
OneToMany
TAAR1 (22 of 92) 35
  • 46 (a)
OneToMany
TAAR1 (32 of 92) 35
  • 33 (a)
OneToMany
TAAR1 (33 of 92) 35
  • 44 (a)
OneToMany
TAAR1 (42 of 92) 35
  • 33 (a)
OneToMany
TAAR1 (44 of 92) 35
  • 35 (a)
OneToMany
TAAR1 (55 of 92) 35
  • 33 (a)
OneToMany
TAAR1 (62 of 92) 35
  • 35 (a)
OneToMany
TAAR1 (64 of 92) 35
  • 35 (a)
OneToMany
TAAR1 (7 of 92) 35
  • 32 (a)
OneToMany
TAAR1 (73 of 92) 35
  • 35 (a)
OneToMany
TAAR1 (74 of 92) 35
  • 33 (a)
OneToMany
TAAR1 (75 of 92) 35
  • 34 (a)
OneToMany
taar10 35
  • 46 (a)
OneToMany
taar10a 35
  • 47 (a)
OneToMany
taar10b 35
  • 49 (a)
OneToMany
taar10c 35
  • 47 (a)
OneToMany
taar10d 35
  • 48 (a)
OneToMany
taar11 35
  • 45 (a)
OneToMany
taar14a 35
  • 33 (a)
OneToMany
taar14d 35
  • 33 (a)
OneToMany
taar14e 35
  • 33 (a)
OneToMany
taar14f 35
  • 33 (a)
OneToMany
taar14g 35
  • 32 (a)
OneToMany
taar14h 35
  • 33 (a)
OneToMany
taar14i 35
  • 34 (a)
OneToMany
taar14j 35
  • 30 (a)
OneToMany
taar14l 35
  • 34 (a)
OneToMany
taar15 35
  • 34 (a)
OneToMany
taar16a 35
  • 34 (a)
OneToMany
taar16b 35
  • 37 (a)
OneToMany
taar16f 35
  • 32 (a)
OneToMany
taar16g 35
  • 32 (a)
OneToMany
taar17a 35
  • 32 (a)
OneToMany
taar18a 35
  • 34 (a)
OneToMany
taar18b 35
  • 34 (a)
OneToMany
taar18c 35
  • 23 (a)
OneToMany
taar18d 35
  • 32 (a)
OneToMany
taar18e 35
  • 33 (a)
OneToMany
taar18f 35
  • 32 (a)
OneToMany
taar18g 35
  • 33 (a)
OneToMany
taar18h 35
  • 34 (a)
OneToMany
taar18i 35
  • 33 (a)
OneToMany
taar18j 35
  • 33 (a)
OneToMany
taar19a 35
  • 34 (a)
OneToMany
taar19b 35
  • 33 (a)
OneToMany
taar19c 35
  • 35 (a)
OneToMany
taar19d 35
  • 34 (a)
OneToMany
taar19e 35
  • 35 (a)
OneToMany
taar19f 35
  • 34 (a)
OneToMany
taar19g 35
  • 35 (a)
OneToMany
taar19h 35
  • 35 (a)
OneToMany
taar19i 35
  • 36 (a)
OneToMany
taar19j 35
  • 33 (a)
OneToMany
taar19k 35
  • 34 (a)
OneToMany
taar19l 35
  • 32 (a)
OneToMany
taar19m 35
  • 34 (a)
OneToMany
taar19n 35
  • 35 (a)
OneToMany
taar19o 35
  • 35 (a)
OneToMany
taar19p 35
  • 35 (a)
OneToMany
taar19q 35
  • 34 (a)
OneToMany
taar19s 35
  • 35 (a)
OneToMany
taar19t 35
  • 35 (a)
OneToMany
taar19u 35
  • 33 (a)
OneToMany
taar1b 35
  • 48 (a)
OneToMany
taar20a 35
  • 34 (a)
OneToMany
taar20a1 35
  • 34 (a)
OneToMany
taar20b 35
  • 35 (a)
OneToMany
taar20b1 35
  • 34 (a)
OneToMany
taar20c 35
  • 33 (a)
OneToMany
taar20c1 35
  • 34 (a)
OneToMany
taar20d1 35
  • 35 (a)
OneToMany
taar20f 35
  • 33 (a)
OneToMany
taar20g 35
  • 34 (a)
OneToMany
taar20h 35
  • 32 (a)
OneToMany
taar20i 35
  • 32 (a)
OneToMany
taar20j 35
  • 34 (a)
OneToMany
taar20l 35
  • 35 (a)
OneToMany
taar20m 35
  • 32 (a)
OneToMany
taar20n 35
  • 34 (a)
OneToMany
taar20o 35
  • 34 (a)
OneToMany
taar20p 35
  • 34 (a)
OneToMany
taar20q 35
  • 34 (a)
OneToMany
taar20r 35
  • 33 (a)
OneToMany
taar20t 35
  • 36 (a)
OneToMany
taar20u 35
  • 33 (a)
OneToMany
taar20w 35
  • 35 (a)
OneToMany
taar20x 35
  • 36 (a)
OneToMany
taar20z 35
  • 34 (a)
OneToMany
taar32 35
  • 35 (a)
OneToMany
Species where no ortholog for TAAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAAR1 Gene

ENSEMBL:
Gene Tree for TAAR1 (if available)
TreeFam:
Gene Tree for TAAR1 (if available)

Paralogs for TAAR1 Gene

Paralogs for TAAR1 Gene

(16) SIMAP similar genes for TAAR1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAAR1 Gene

genes like me logo Genes that share paralogs with TAAR1: view

Variants for TAAR1 Gene

Sequence variations from dbSNP and Humsavar for TAAR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs8192618 - 132,645,937(-) ATGTC(C/T)GTGCT reference, missense
rs6926857 - 132,645,250(+) CAATG(C/T)CTTCA reference, missense
rs4897595 -- 132,646,232(+) GAAGG(A/G)ACTTT upstream-variant-2KB
rs8192617 -- 132,646,161(-) AATTG(C/T)CAATG upstream-variant-2KB
rs8192619 -- 132,645,209(-) TGGTG(C/T)CCTTT reference, synonymous-codon

Variation tolerance for TAAR1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAAR1 Gene

Human Gene Mutation Database (HGMD)
TAAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAAR1 Gene

Disorders for TAAR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAAR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
superficial urinary bladder cancer
  • superficial urinary bladder carcinoma
paralytic ileus
  • paralysis of intestine or colon
- elite association - COSMIC cancer census association via MalaCards
Search TAAR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAAR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAAR1
genes like me logo Genes that share disorders with TAAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAAR1 Gene

Publications for TAAR1 Gene

  1. Trace amines: identification of a family of mammalian G protein- coupled receptors. (PMID: 11459929) Borowsky B. … Gerald C. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 25 65
  2. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PMID: 15718104) Lindemann L. … Hoener M.C. (Genomics 2005) 2 3 4 65
  3. Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1. (PMID: 18602830) Lewin A.H. … Mascarella S.W. (Bioorg. Med. Chem. 2008) 3 22 65
  4. Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes. (PMID: 17900709) Nelson D.A. … Bost K.L. (J. Neuroimmunol. 2007) 3 22 65
  5. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. (PMID: 17218486) Reese E.A. … Grandy D.K. (J. Pharmacol. Exp. Ther. 2007) 22 25 65

Products for TAAR1 Gene

Sources for TAAR1 Gene

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