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TAAR1 Gene

protein-coding   GIFtS: 53
GCID: GC06M132966

Trace Amine Associated Receptor 1

(Previous name: trace amine receptor 1)
(Previous symbol: TRAR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trace Amine Associated Receptor 11 2     TAR12 3
Trace Amine Receptor 11 2 3     taR-12
TRAR11 2 3     Trace Amine-Associated Receptor 12
TA12 3 5     TaR-13

External Ids:    HGNC: 177341   Entrez Gene: 1348642   Ensembl: ENSG000001463997   OMIM: 6093335   UniProtKB: Q96RJ03   

Export aliases for TAAR1 gene to outside databases

Previous GC identifers: GC06M133008 GC06M130541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAAR1 Gene:
TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine compounds that
account for less than 1% of the biogenic amines in most brain regions (Bunzow et al., 2001 (PubMed
11723224)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TAAR1 Gene:
TAAR1 (trace amine associated receptor 1) is a protein-coding gene. Diseases associated with TAAR1 include schizophrenia, and hiv-1. GO annotations related to this gene include trace-amine receptor activity and G-protein coupled receptor activity. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0
Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and
tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as
epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic
amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as
neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates
has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that
have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of
G-proteins which activate adenylate cyclase

Gene Wiki entry for TAAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAAR1 gene promoter:
         TBP   AP-1   ATF-2   FOXD3   CUTL1   HNF-3beta   TFIID   c-Jun   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAAR1 promoter sequence
   Search Chromatin IP Primers for TAAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.1

TAAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAAR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132966:  view genomic region     (about GC identifiers)

Start:
132,966,123 bp from pter      End:
132,967,142 bp from pter
Size:
1,020 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0 (See protein sequence)
Recommended Name: Trace amine-associated receptor 1  
Size: 339 amino acids; 39092 Da
Secondary accessions: Q2M1W5 Q3MIH8 Q5VUQ1

Explore the universe of human proteins at neXtProt for TAAR1: NX_Q96RJ0

Explore proteomics data for TAAR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn17

  • See TAAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612200.1  
    ENSEMBL proteins: 
     ENSP00000275216  
    Reactome Protein details: Q96RJ0

    TAAR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TAAR1

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    Cloud-Clone Corp. ELISAs for TAAR1
    Cloud-Clone Corp. CLIAs for TAAR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TAAR: GPCR / Class A : Trace amine associated receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TA1 receptor
    Trace amine receptor

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009133 TAAR1
     IPR009132 TAAR_fam
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96RJ0

    ProtoNet protein and cluster: Q96RJ0

    UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    TAAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAAR1_HUMAN, Q96RJ0
    Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and
    tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as
    epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic
    amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as
    neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates
    has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that
    have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of
    G-proteins which activate adenylate cyclase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001594trace-amine receptor activity IEA--
    GO:0004930G-protein coupled receptor activity TAS15718104
    GO:0008227G-protein coupled amine receptor activity ----
         
    TAAR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAAR1:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Taar1):
     behavior/neurological  homeostasis/metabolism  nervous system  no phenotypic analysis 

    TAAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taar1tm1Tdw for TAAR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAAR1

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAAR1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAAR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAAR1_HUMAN, Q96RJ0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    TAAR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAAR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Monoamine GPCRs
    Amine ligand-binding receptors0.79
    4G alpha (s) signalling events
    G alpha (s) signalling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TAAR1
        G alpha (s) signalling events
    Amine ligand-binding receptors


    1 Kegg Pathway  (Kegg details for TAAR1):
        Neuroactive ligand-receptor interaction


    TAAR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TAAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TAAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAAR1 (ENSP000002752164) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRB1ENSP000003583014STRING: ENSP00000358301
    ADRB2ENSP000003053724STRING: ENSP00000305372
    GNASENSP000003601414STRING: ENSP00000360141
    MC3RENSP000002439114STRING: ENSP00000243911
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS15718104

    TAAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAAR1

    2 HMDB Compounds for TAAR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Epinephrine(-)-(R)-Epinephrine (see all 72)51-43-4--
    Tyramine2-(4'-Hydroxyphenyl)ethylamine (see all 34)51-67-2--

    4 DrugBank Compounds for TAAR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Methamphetamine(+ )-methylamphetamine (see all 46)537-46-2targetagonist15764732 17218486 17234900 17888514 17234899 17212650 11459929
    Amphetamine(+/-)-Benzedrine (see all 19)300-62-9targetagonist15764732 17218486 17234900 17234899 17212650
    Dextroamphetamine(+)-(S)-amphetamine (see all 5)51-64-9targetagonist15764732 17218486 17234900 17234899 17212650
    Propylhexedrine-- 3595-11-7targetagonist15764732 17218486 17234900 17234899 17212650

    8 IUPHAR Ligands for TAAR1 (TA1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]tyramine
    AgonistFull agonist7.711459929
    RO5166017
    AgonistFull agonist7.321525407
    beta-phenylethylamine
    AgonistFull agonist6.2 - 717038507 18524885 18602830 19725810 22073124 11459929
    dextroamphetamine
    AgonistFull agonist6 - 6.918524885 22037049
    tyramine
    AgonistFull agonist5.8 - 6.717038507 18524885 19725810 22073124 11459929 19892733
    R(-)amphetamine
    AgonistFull agonist6.618524885
    octopamine
    AgonistFull agonist4.8 - 5.817038507 18524885 19725810 22073124 11459929
    EPPTB
    AntagonistInverse agonist5.119892733

    6 Novoseek inferred chemical compound relationships for TAAR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-phenylethylamine 90 9 17218486 (1), 17900709 (1), 17888514 (1), 20155805 (1)
    tyramine 83.6 5 17900709 (1), 17888514 (1)
    amine 70.7 18 20155805 (2), 15764732 (2), 18524885 (2), 18602830 (1) (see all 8)
    amphetamine 65.7 5 17218486 (5)
    methamphetamine 60.9 7 17218486 (3), 17234899 (2), 20155805 (1)
    dopamine 44.9 34 17234899 (5), 18310473 (3), 15764732 (2), 16786561 (1) (see all 5)



    TAAR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAAR1 gene: 
    NM_138327.1  

    Unigene Cluster for TAAR1:

    Trace amine associated receptor 1
    Hs.375030  [show with all ESTs]
    Unigene Representative Sequence: BC112194
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000275216(uc003qdm.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TAAR1
      QuantiFast Probe-based Assays in human, mouse, rat TAAR1

    Additional mRNA sequence: 

    AY180374.1 BC101825.1 BC112194.1 

    1 DOTS entry:

    DT.95235330 

    6 AceView cDNA sequences:

    NM_138327 AY180374 CN839307 CN838940 CN832845 CN832787 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCTTTTC
    TAAR1 Expression
    About this image

    TAAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375030

    UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0
    Tissue specificity: Detected in low levels in discrete regions within the central nervous system and in several
    peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small
    intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas,
    pituitary, pontine reticular formation, prostate, skeletal muscle and spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including TAAR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TAAR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAAR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAAR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taar11 , 5 trace amine-associated receptor 11, 5 78.92(n)1
    75.9(a)1
      10 (11.39 cM)5
    1111741  NM_053205.11  NP_444435.11 
     239204065 
    chicken
    (Gallus gallus)
    Aves TAAR11 trace amine associated receptor 1 70.18(n)
    70.18(a)
      768536  XM_004935740.1  XP_004935797.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAAR16
    trace amine associated receptor 1
    64(a)
    1 ↔ 1
    GL343200.1(4463427-4464437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia taar11 trace amine associated receptor 1 67.97(n)
    65.47(a)
      100487786  XM_002935811.2  XP_002935857.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taar1b1 trace amine associated receptor 1b 56.9(n)
    48.34(a)
      794715  NM_001082904.1  NP_001076373.1 


    ENSEMBL Gene Tree for TAAR1 (if available)
    TreeFam Gene Tree for TAAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAAR1 gene
    TAAR62  HTR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  DRD12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    16 SIMAP similar genes for TAAR1 using alignment to 1 protein entry:     TAAR1_HUMAN:
    TAAR3    TAAR2    TAAR9    TAAR6    TAAR5    TAAR8
    HTR4    HTR4B    ADRB2    HRH2    ADRA1A    DRD1
    ADRA1B    HTR5A    HTR1D    HTR2A

    TAAR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAAR1
    PGOHUM00000243373


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAAR1 (see all 161)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156890211,2
    F--132965630(+) GGAATA/GTATAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs93759061,2
    C,F,H--132965675(+) TTAGCG/AGTAAC 1 -- ds50016Minor allele frequency- A:0.25NS EA NA 638
    rs614786611,2
    C,F--132965751(+) TATACG/ATATAT 1 -- ds50016Minor allele frequency- A:0.05NA WA EA 364
    rs1180446321,2
    C,F--132965886(+) GTAGGC/TCTTTA 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1462811831,2
    C--132965940(+) AAAGCA/GTATAC 1 -- ds50010--------
    rs1391851421,2
    --132965961(+) CCAAAG/TAGGAA 1 -- ds50010--------
    rs1497761581,2
    --132965969(+) GAAATG/TACCTA 1 -- ds50010--------
    rs1456869011,2
    --132965995(+) AACTCA/GCCATA 1 -- ds50010--------
    rs93759071,2
    C,F,H--132966043(+) CATGTG/TGTTGG 1 -- ds500117Minor allele frequency- T:0.19NS EA NA CSA 2224
    rs1137888941,2
    F--132966064(+) TCGTTG/ATGTTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TAAR1 (132966123 - 132967142 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAAR1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609333    OMIM disorders: --

    4 diseases for TAAR1:    
    About MalaCards
    schizophrenia    hiv-1    neuronitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TAAR1:
    Schizophrenia

    TAAR1 for disorders           About GeneDecksing


    Export disorders for TAAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAAR1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with TAAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)1, 2, 3, 7 Borowsky B.... Gerald C. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)1, 2, 3 Lindemann L....Hoener M.C. (Genomics 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. (PubMed id 11723224)1, 2 Bunzow J.R.... Grandy D.K. (Mol. Pharmacol. 2001)
    6. Trace amine-associated receptor 1 is a modulator of the dopamine transporter. (PubMed id 17234899)7, 9 Xie Z. and Miller G.M. (J. Pharmacol. Exp. Ther. 2007)
    7. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. (PubMed id 17218486)7, 9 Reese E.A....Grandy D.K. (J. Pharmacol. Exp. Ther. 2007)
    8. Primate trace amine receptor 1 modulation by the dopamine transporter. (PubMed id 15764732)7, 9 Miller G.M....Madras B.K. (J. Pharmacol. Exp. Ther. 2005)
    9. Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes. (PubMed id 17900709)1, 9 Nelson D.A....Bost K.L. (J. Neuroimmunol. 2007)
    10. Trace amine-associated receptor 1-Family archetype or iconoclast? (PubMed id 17888514)7, 9 Grandy D.K. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134864 HGNC: 17734 AceView: TRAR1 Ensembl:ENSG00000146399 euGenes: HUgn134864
    ECgene: TAAR1 Kegg: 134864 H-InvDB: TAAR1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAAR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAAR1 gene:
    Search GeneIP for patents involving TAAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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