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Aliases &
Descriptions
for TAAR1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| MGC126874 2 | | MGC138399 2 | | OTTHUMP00000017224 2 | | RP11-295F4.9 2 | | TA1 1, 2, 3, 5 | | TAR1 1, 2, 3 | | TRAR1 2, 3 | | TaR-1 3 |
| | | Descriptions |
|---|
| Trace amine receptor 1 1, 2, 3 | | trace amine associated receptor 1 2 |
|
| |
Search outside databases for aliases for TAAR1 gene |
Summaries
for TAAR1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TAAR1:
TAAR1 is a G protein-coupled receptor activated by trace amines. Trace amines are endogenous amine
compounds that account for less than 1% of the biogenic amines in most brain regions (Bunzow et
al., 2001 [PubMed 11723224]).[supplied by OMIM]
UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR),
octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical
biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and
serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues.
Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the
extent to which they function as true neurotransmitters in vertebrates has remained speculative.
Trace amines are likely to be involved in a variety of physiological functions that have yet to be
fully understood. The signal transduced by this receptor is mediated by the G(s)-class of
G-proteins which activate adenylate cyclaseGene Wiki entry for TAAR1 |
Genomic Location
for TAAR1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the TAAR1 gene 
Entrez Gene cytogenetic band: 6q23.2 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.1TAAR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M133008:
(about GC identifiers)
Start:
|
133,007,816 bp from pter |
End:
|
133,008,835 bp from pter |
Size:
|
1,020 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_025741.14
| Proteins
for TAAR1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0 (See
protein sequence)Recommended Name: Trace amine-associated receptor 1 Size: 339 amino acids; 39092 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M1W5 Q3MIH8 Q5VUQ1REFSEQ proteins: NP_612200.1
ENSEMBL proteins: ENSP00000275216
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
Antibodies for TAAR1:
Assays for TAAR1: | Protein
Domains/
Families
for TAAR1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96RJ0
ProtoNet protein and cluster: Q96RJ0 UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function
for TAAR1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138327
 Applied Biosystems Silencer® siRNAs for TAAR1
 Sigma-Aldrich siRNA and siRNA Panels for TAAR1
Sigma-Aldrich shRNA Panels and shRNA for TAAR1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_138327
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138327
untagged cDNA clone in CMV expression vector: NM_138327
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_138327
UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0Function: Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR),
octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical
biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and
serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues.
Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the
extent to which they function as true neurotransmitters in vertebrates has remained speculative.
Trace amines are likely to be involved in a variety of physiological functions that have yet to be
fully understood. The signal transduced by this receptor is mediated by the G(s)-class of
G-proteins which activate adenylate cyclase3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Taar1):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001594 | trace-amine receptor activity |
IEA | -- | | GO:0004872 | receptor activity |
IEA | -- |
About this table | Pathways & Interactions
for TAAR1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5 Interacting proteins for TAAR1 (ENSP000002752163) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
TAS | 15718104 |
About this table
|
Drugs & Compounds
for TAAR1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAAR1
1  Novoseek chemical compound relationship for TAAR1 gene
About this table
|
Transcripts
for TAAR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138327
Sigma-Aldrich siRNA and siRNA Panels for TAAR1
Sigma-Aldrich shRNA Panels and shRNA for TAAR1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_138327 REFSEQ mRNAs for TAAR1 gene: NM_138327.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_138327
OriGene GFP tagged cDNA clone in CMV expression vector: NM_138327
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138327
untagged cDNA clone in CMV expression vector: NM_138327
Additional cDNA sequence: AY180374.1 BC101825.1 BC112194.1 1 DOTS entry: DT.95235330 6 AceView cDNA sequences:CN839307 AY180374 NM_138327 CN832845 CN832787 CN838940
 highest scoring ESTs for TAAR1:AW813121 AY180374 CN832787 CN832845 CN838940 CN839307 NM_138327 BC101825 BC112194 CO957854 Unigene Cluster for TAAR1: Trace amine associated receptor 1 Hs.375030 [show with all ESTs]Unigene Representative Sequence: BC112194
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000275216
|
Expression
for TAAR1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAAR1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAAR1
1 / 2 1 probe-set matching TAAR1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GACCCTTTTC
SOURCE GeneReport for Unigene cluster: Hs.375030
UniProtKB/Swiss-Prot: TAAR1_HUMAN, Q96RJ0Tissue specificity: Detected in low levels in discrete regions within the central nervous system
and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala,
kidney, and lung, and small intestin. Trace amounts in cerebellum, dorsal root ganglia,
hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation,
prostate, skeletal muscle, and spleen |
Orthologs
for TAAR1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAAR1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for TAAR1
ENSEMBL Gene Tree for TAAR1 | Paralogs
for TAAR1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAAR1 gene
- TAAR22
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants
for TAAR1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TAAR1 (up to first 250kb)
|
Disorders & Mutations
for TAAR1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609333
|
Medical News
for TAAR1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TAAR1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for TAAR1 gene (see all 22
):- Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. (PubMed id 15718104)2, 3, 4 Lindemann L....Hoener M.C. (2005)
- Trace amines: identification of a family of mammalian G protein- coupled receptors. (PubMed id 11459929)2, 3, 4 Borowsky B.... Gerald C. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. (PubMed id 11723224)3, 4 Bunzow J.R.... Grandy D.K. (2001)
- Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes. (PubMed id 17900709)1, 3 Nelson D.A....Bost K.L. (2007)
- Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1. (PubMed id 18602830)1, 3 Lewin A.H....Mascarella S.W. (2008)
- A second class of chemosensory receptors in the olfactory epithelium. (PubMed id 16878137)3 Liberles S.D. and Buck L.B. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. (PubMed id 18310473)1 Xie Z....Miller G.M. (2008)
|
Search for TAAR1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAAR1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAAR1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAAR1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for TAAR1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for TAAR1:
 | |
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(TA1) | | | Antibodies (TA1) |
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