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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

T Gene

protein-coding   GIFtS: 60
GCID: GC06M166541

T, Brachyury Homolog (Mouse)

(Previous name: T brachyury (mouse) homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T, Brachyury Homolog (Mouse)1 2     Brachyury Protein2
Protein T2 3     T Brachyury Homolog2
T Brachyury (Mouse) Homolog1     TF5
TFT2     

External Ids:    HGNC: 115151   Entrez Gene: 68622   Ensembl: ENSG000001644587   OMIM: 6013975   UniProtKB: O151783   

Export aliases for T gene to outside databases

Previous GC identifers: GC06M165924 GC06M166444 GC06M166481 GC06M166482 GC06M164037


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for T Gene:
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA
element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects
transcription of genes required for mesoderm formation and differentiation. The protein is localized to
notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2012)

GeneCards Summary for T Gene: 
T (T, brachyury homolog (mouse)) is a protein-coding gene. Diseases associated with T include chordoma, and parachordoma. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178
Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation.
Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site

Gene Wiki entry for T (Brachyury) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the T gene promoter:
         SREBP-1c   p300   Pax-2a   HNF-4alpha2   C/EBPalpha   SREBP-1b   HNF-4alpha1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidT promoter sequence
   Search SABiosciences Chromatin IP Primers for T

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat T


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

T Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
T gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M166541:  view genomic region     (about GC identifiers)

Start:
166,571,086 bp from pter      End:
166,582,188 bp from pter
Size:
11,103 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178 (See protein sequence)
Recommended Name: Brachyury protein  
Size: 435 amino acids; 47443 Da
Subunit: Monomer (By similarity)
Subcellular location: Nucleus
Secondary accessions: E7ERD6 Q4KMP4
Alternative splicing: 2 isoforms:  O15178-1   O15178-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for T: NX_O15178

Explore proteomics data for T at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15178

  • T Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    T Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257413.1  NP_003172.1  

    ENSEMBL proteins: 
     ENSP00000296946   ENSP00000355836   ENSP00000355841   ENSP00000453512  

    Human Recombinant Protein Products for T: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for T 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--

    T for ontologies           About GeneDecksing



    T Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TBX: T-boxes

    4 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR002070 TF_Brachyury
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O15178

    ProtoNet protein and cluster: O15178

    2 Blocks protein domains:
    IPB001699 Transcription factor
    IPB002070 Brachyury protein family signature


    UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178
    Similarity: Contains 1 T-box DNA-binding domain


    T for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRAC_HUMAN, O15178
    Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation.
    Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site

         Genatlas biochemistry entry for T:
    murine T-box gene Tbx (T,brachyury) homolog,expressed in cells derived from the notochord,crucial for mesoderm
    formation,no evidence of association with neural tube defects (NTD) in Netherlands and U.K.

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS--
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0001085RNA polymerase II transcription factor binding ISS--
    GO:0001102RNA polymerase II activating transcription factor binding IPI--
         
    T for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 37 alleles(MGI details for T) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging 
     nervous system  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    T for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for T 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for T 
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    SwitchGear 3'UTR luciferase reporter plasmidT 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for T About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct-3/4
    Selected targets of Oct-3/4
    2Selected targets of HNF1
    Selected targets of HNF1
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    4Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for T
        Selected targets of Oct-3/4
    Selected targets of HNF1


    1 Cell Signaling Technology (CST) Pathway for T
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for T
        Cardiac Progenitor Differentiation
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    T for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for T

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for T (ENSP000002969464) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLDENSP000002054024STRING: ENSP00000205402
    GLDCENSP000003707374STRING: ENSP00000370737
    LEF1ENSP000002651654STRING: ENSP00000265165
    OCA2ENSP000003466594STRING: ENSP00000346659
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001570vasculogenesis IEA--
    GO:0001756somitogenesis IEA--
    GO:0001839neural plate morphogenesis IEA--
    GO:0001843neural tube closure IEA--

    T for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for T (BRAC)

    Search CenterWatch for drugs/clinical trials and news about T / BRAC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for T gene (2 alternative transcripts): 
    NM_001270484.1  NM_003181.3  

    Unigene Cluster for T:

    T, brachyury homolog (mouse)
    Hs.389457  [show with all ESTs]
    Unigene Representative Sequence: NM_003181
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296946(uc003qut.1 uc003quu.1) ENST00000366871(uc003quv.1)
    ENST00000366876 ENST00000461348
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    hsa-miR-3678-3p hsa-miR-448 hsa-miR-539 hsa-miR-219-5p hsa-miR-507 hsa-miR-508-3p hsa-miR-511 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidT 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ001699.1 BC039877.1 BC098425.1 

    5 DOTS entries:

    DT.97837890  DT.97837889  DT.202766  DT.100737559  DT.75161871 

    24/48 AceView cDNA sequences (see all 48):

    NM_003181 BQ925830 AI341816 BF512284 BF223613 BQ430235 AI797600 AA994493 
    AI651456 BQ221790 BU192473 BG490984 BQ222875 BQ924827 BQ931406 BE785653 
    BF182766 AJ001699 BG332916 BQ927155 BQ422302 BU190437 BU164583 BQ221957 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for T    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                          -     -                                         -     -                     
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                    -     -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for T

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    T expression in normal human tissues (normalized intensities)      T embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGCAGCA
    T Expression
    About this image


    T expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 12 entries
             Mesoderm Progenitor Cells Posterior Primitive Streak
             Mesendoderm embryoid bodies ( Mouse embryonic stem cell differentiation into mesoderm,...
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 9 entries
             Mesoderm Cells Mesoderm
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Nucleus Pulposus Cells Sacral Intervertebral Disc
             Chondrocyte-like cells ( Direct differentiation of human embryonic stem cells into...
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Expanded pancreatic progenitor cells ( Derivation of beta cells including an expansion...

    See T Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for T

    SOURCE GeneReport for Unigene cluster: Hs.389457
        SABiosciences Expression via Pathway-Focused PCR Arrays including T: 
              Cell Lineage Identification in human mouse rat
              WNT Signaling Targets in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for T

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for T gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia T1 , 5 brachyury1, 5 85.71(n)1
    91.71(a)1
      17 (4.92 cM)5
    209971  NM_009309.21  NP_033335.11 
     84344235 
    chicken
    (Gallus gallus)
    Aves T1 T, brachyury homolog (mouse) 81.13(n)
    80.93(a)
      395782  NM_204940.1  NP_990271.1 
    lizard
    (Anolis carolinensis)
    Reptilia T6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343461.1(588141-608138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5142 Xenopus laevis brachyury (T) (Xbra) gene, complete cds less 76.01(n)    M77243.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntl2 no tail 78.83(n)   30399  NM_131162.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta byn1 , 3 Malpighian tubule morphogenesis RNA
    polymerase II transcription factor less3
    brachyenteron1
    68(a)3
    56.98(n)1
    55.84(a)1
      68E33
    393491  NM_079307.11  NP_524031.11 


    ENSEMBL Gene Tree for T (if available)
    TreeFam Gene Tree for T (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for T gene
    TBX12  TBX222  TBX192  EOMES2  TBX22  TBX62  TBX212  TBX202  
    TBX32  TBX52  TBX152  TBR12  TBX102  TBX42  TBX182  
    14 SIMAP similar genes for T using alignment to 3 protein entries:     BRAC_HUMAN (see all proteins):
    TBX19    TBX6    TBX1    MGA    TBX18    TBX10
    TBX20    TBX4    DKFZp762H2012    TBX2    EOMES    TBX5
    TBR1    TBX21

    T for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for T
    PGOHUM00000244365 PGOHUM00000235170


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/392 SNPs in T are shown (see all 392)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58816821,2
    C,F--164040167(+) CAATTG/-AATTC 2 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1997318281,2
    C--164040167(+) CAATTA/G/TAATTC 2 -- int10--------
    rs558223661,2
    C--166575410(+) AAAAA-/AGCACA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3708774351,2
    C--166578166(+) AAAAA-/AGTATA 2 -- int10--------
    rs22770941,2
    C,F,H--166580753(-) CTGCAA/GTGGCG 2 -- int1 ds500115Minor allele frequency- G:0.08EA NA NS CSA WA 2414
    rs22770931,2
    C,F,A--166580827(-) TTACCA/GTAGCA 2 -- int1 ds500115Minor allele frequency- G:0.21EA NA WA CSA 1969
    rs1153607611,2
    F--166581115(+) AAATGC/TTTTTT 2 -- int1 ds50011Minor allele frequency- T:0.02WA 118
    rs11344821,2
    C,F,A,H--166581218(-) ATAAAT/CGCAAT 2 -- ut31 ese311Minor allele frequency- C:0.25NA WA CSA EA 372
    rs11344811,2
    C,F,A,H--166581225(-) CTGCAC/AAATAA 2 -- ut3114Minor allele frequency- A:0.24NS EA NA WA CSA 783
    rs31273271,2
    H--166581341(+) ACATTC/ATAGGG 2 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for T (166571086 - 166582188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for T:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733170CNV Deletion23290073
    esv2733168CNV Deletion23290073
    esv2733169CNV Deletion23290073
    nsv886933CNV Loss21882294


    Human Gene Mutation Database (HGMD): T
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601397   
    OMIM disorders: 182940  
    UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and
    adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of
    neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly,
    myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of
    the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry
  • Chordoma (CHDM) [MIM:215400]: Rare, clinically malignant tumors derived from notochordal remnants. They
    occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal
    regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues
    and rarely, distant metastatic spread. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication

  • 20/62 diseases for T (see all 62):    About MalaCards
    chordoma    parachordoma    thoracolumbosacral spina bifida cystica    upper thoracic spina bifida aperta
    cervical spina bifida cystica    cervicothoracic spina bifida aperta    lumbosacral spina bifida cystica    cervical spina bifida aperta
    upper thoracic spina bifida cystica    total spina bifida cystica    total spina bifida aperta    lumbosacral spina bifida aperta
    cervicothoracic spina bifida cystica    thoracolumbosacral spina bifida aperta    genital herpes    autoimmune hemolytic anemia
    hairy cell leukemia    myoepithelioma    alopecia areata    neural tube defects


    T for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for T gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis 22.3 1 17923080 (1), 11994418 (1)
    inflammation 18.4 3 19412181 (1), 17723218 (1), 15498029 (1)
    asthma 6.56 1 15604153 (1)

    Genetic Association Database (GAD): T
    Human Genome Epidemiology (HuGE) Navigator: T (0 documents)

    Export disorders for T gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for T gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with T)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. (PubMed id 8963900)1, 2, 3, 9 Edwards Y.H....Sowden J. (1996)
    2. T (brachyury) gene duplication confers major suscepti bility to familial chordoma. (PubMed id 19801981)1, 2 Yang X.R....Kelley M.J. (2009)
    3. A Missense T(Brachyury) Mutation Contributes to Vertebral Malformations. (PubMed id 18466071)1, 4 Ghebranious N....Giampietro P.F. (2008)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The human T locus and spina bifida risk. (PubMed id 15449172)2, 9 Jensen L.E....Mitchell L.E. (2004)
    6. Malignant tumors with clear cell morphology: a compara tive immunohistochemical study with renal cell carcinoma antibody, Pax8, steroid ogenic factor 1, and brachyury. (PubMed id 23218904)1 Clayton E.F....Bing Z. (2013)
    7. Genome-wide association identifies the T gene as a nov el asthma pharmacogenetic locus. (PubMed id 22538805)1 Tantisira K.G....Israel E. (2012)
    8. T-box transcription factor Brachyury expression is cor related with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma. (PubMed id 23076115)1 Imajyo I....Mori Y. (2012)
    9. An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma. (PubMed id 22847733)1 Nelson A.C....Flanagan A.M. (2012)
    10. Placenta to cartilage: direct conversion of human plac enta to chondrocytes with transformation by defined factors. (PubMed id 22833560)1 Ishii R....Umezawa A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6862 HGNC: 11515 AceView: T Ensembl:ENSG00000164458 euGenes: HUgn6862
    ECgene: T H-InvDB: T

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for T Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for T gene:
    Search GeneIP for patents involving T

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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