Aliases for T Gene
External Ids for T Gene
Previous GeneCards Identifiers for T Gene
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for T Gene
T (T, Brachyury Homolog (Mouse)) is a Protein Coding gene. Diseases associated with T include sacral agenesis with vertebral anomalies and chordoma. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is TBX20.
UniProtKB/Swiss-Prot for T Gene
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site