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Aliases for STAT2 Gene

Aliases for STAT2 Gene

  • Signal Transducer And Activator Of Transcription 2 2 3 5
  • Signal Transducer And Activator Of Transcription 2, 113kDa 2 3
  • P113 3 4
  • Signal Transducer And Activator Of Transcription 2, 113kD 2
  • Interferon Alpha Induced Transcriptional Activator 3
  • STAT113 3
  • ISGF-3 3
  • IMD44 3

External Ids for STAT2 Gene

Previous GeneCards Identifiers for STAT2 Gene

  • GC12P056573
  • GC12P056545
  • GC12M056453
  • GC12M055022
  • GC12M055021
  • GC12M056735
  • GC12M053774

Summaries for STAT2 Gene

Entrez Gene Summary for STAT2 Gene

  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for STAT2 Gene

STAT2 (Signal Transducer And Activator Of Transcription 2) is a Protein Coding gene. Diseases associated with STAT2 include Primary Immunodeficiency Due To Stat2 Deficiency and Mumps. Among its related pathways are Interferon gamma signaling and CXCR4-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is STAT1.

UniProtKB/Swiss-Prot for STAT2 Gene

  • Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at Ser-616 and Ser-637 which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).

Gene Wiki entry for STAT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STAT2 Gene

Genomics for STAT2 Gene

Regulatory Elements for STAT2 Gene

Enhancers for STAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057109 1.1 ENCODE 39.6 -751.0 -751001 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 SP3 NEMP1 BAZ2A ANKRD52 CTDSP2 RN7SL809P ENSG00000224713 ENSG00000258317 ZC3H10 TSPAN31 RNU6-343P
GH12F056718 0.6 ENCODE 38.1 -362.3 -362306 8.9 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 BAZ2A ANKRD52 RN7SL809P ENSG00000224713 TMEM198B ZC3H10 RNU6-343P CDK2 SMARCC2
GH12F056220 0.4 ENCODE 30.9 +137.4 137372 5.7 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEMP1 ANKRD52 BAZ2A PHC1P1 ZBTB39 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2
GH12F055826 0.8 FANTOM5 30.8 +534.1 534075 0.2 ZNF493 ZFP64 INSM2 ZEB1 ZNF366 ZNF354C KLF7 ZNF202 ZNF680 ZNF654 ANKRD52 BAZ2A PHC1P1 TMEM198B SMARCC2 RN7SL809P ENSG00000258317 STAT2 ZC3H10 ENSG00000257740
GH12F056040 0.8 FANTOM5 ENCODE 27.6 +318.3 318254 3.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BAZ2A RNU6-343P RBMS2 RN7SL809P RPL41 ENSG00000258199 CDK2 STAT2 SUOX RAB5B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around STAT2 on UCSC Golden Path with GeneCards custom track

Promoters for STAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001463829 153 2601 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for STAT2 Gene

Chromosome:
12
Start:
56,341,597 bp from pter
End:
56,360,253 bp from pter
Size:
18,657 bases
Orientation:
Minus strand

Genomic View for STAT2 Gene

Genes around STAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STAT2 Gene

Proteins for STAT2 Gene

  • Protein details for STAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52630-STAT2_HUMAN
    Recommended name:
    Signal transducer and activator of transcription 2
    Protein Accession:
    P52630
    Secondary Accessions:
    • B4DLC7
    • G3V2M6
    • Q16430
    • Q16431
    • Q9UDL4

    Protein attributes for STAT2 Gene

    Size:
    851 amino acids
    Molecular mass:
    97916 Da
    Quaternary structure:
    • Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. The heterodimer STAT1:STAT2 forms the interferon-stimulated gene factor 3 complex (ISGF3) with IRF9; interacts with IRF9 in the cytoplasm. Interacts with CRSP2 and CRSP6. Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at Tyr-466. Interacts with IFNAR2. Interacts with ARL2BP. Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation. Interacts with human cytomegalovirus/HHV-5 protein UL123; this interaction promotes viral growth. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.
    SequenceCaution:
    • Sequence=AAB36226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAB36227.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for STAT2 Gene

    Alternative splice isoforms for STAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for STAT2 Gene

Post-translational modifications for STAT2 Gene

  • Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response.
  • Ubiquitination at Lys 384, Lys 523, and Lys 681
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for STAT2 Gene

Domains & Families for STAT2 Gene

Gene Families for STAT2 Gene

Suggested Antigen Peptide Sequences for STAT2 Gene

Graphical View of Domain Structure for InterPro Entry

P52630

UniProtKB/Swiss-Prot:

STAT2_HUMAN :
  • Contains 1 SH2 domain.
  • Belongs to the transcription factor STAT family.
Domain:
  • Contains 1 SH2 domain.
Family:
  • Belongs to the transcription factor STAT family.
genes like me logo Genes that share domains with STAT2: view

Function for STAT2 Gene

Molecular function for STAT2 Gene

GENATLAS Biochemistry:
signal transducer and activator of transcription,interacting specifically with CBP/p300 in signaling induced by interferon-alpha
UniProtKB/Swiss-Prot Function:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at Ser-616 and Ser-637 which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).

Gene Ontology (GO) - Molecular Function for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 8605876
GO:0042802 identical protein binding IPI 8605877
genes like me logo Genes that share ontologies with STAT2: view
genes like me logo Genes that share phenotypes with STAT2: view

Animal Models for STAT2 Gene

MGI Knock Outs for STAT2:

Animal Model Products

Transcription Factor Targets for STAT2 Gene

Selected GeneGlobe predicted Target genes for STAT2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for STAT2 Gene

Localization for STAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STAT2 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for STAT2 Gene COMPARTMENTS Subcellular localization image for STAT2 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with STAT2: view

Pathways & Interactions for STAT2 Gene

genes like me logo Genes that share pathways with STAT2: view

SIGNOR curated interactions for STAT2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for STAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IMP 26122121
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9020188
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with STAT2: view

Drugs & Compounds for STAT2 Gene

(5) Drugs for STAT2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niclosamide Approved, Vet_approved Pharma 7

(7) Additional Compounds for STAT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for STAT2 Gene

Compound Action Cas Number
Niclosamide 50-65-7
genes like me logo Genes that share compounds with STAT2: view

Transcripts for STAT2 Gene

Unigene Clusters for STAT2 Gene

Signal transducer and activator of transcription 2, 113kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for STAT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:

ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for STAT2 Gene

GeneLoc Exon Structure for
STAT2
ECgene alternative splicing isoforms for
STAT2

Expression for STAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for STAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STAT2 Gene

This gene is overexpressed in Monocytes (13.5), Bone marrow stromal cell (9.1), Lymph node (8.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STAT2 Gene



Protein tissue co-expression partners for STAT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of STAT2 Gene:

STAT2

SOURCE GeneReport for Unigene cluster for STAT2 Gene:

Hs.530595
genes like me logo Genes that share expression patterns with STAT2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for STAT2 Gene

Orthologs for STAT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for STAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia STAT2 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia STAT2 34
  • 87.65 (n)
-- 35
  • 86 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia STAT2 34 35
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia Stat2 34
  • 78.52 (n)
mouse
(Mus musculus)
Mammalia Stat2 34 16 35
  • 77.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia STAT2 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves STAT2 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STAT2 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stat2 34
  • 56.03 (n)
zebrafish
(Danio rerio)
Actinopterygii stat2 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Stat92E 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sta-1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
ManyToMany
Species where no ortholog for STAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STAT2 Gene

ENSEMBL:
Gene Tree for STAT2 (if available)
TreeFam:
Gene Tree for STAT2 (if available)

Paralogs for STAT2 Gene

Variants for STAT2 Gene

Sequence variations from dbSNP and Humsavar for STAT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs281874770 Pathogenic 56,355,703(-) GGTGA(C/G)GACAA intron-variant, upstream-variant-2KB
rs781522558 Pathogenic 56,346,844(+) CAGGA(C/G)CAGGT nc-transcript-variant, downstream-variant-500B, reference, missense
rs149666262 Uncertain significance 56,351,143(+) GGGGT(C/T)GATGG nc-transcript-variant, reference, missense
rs386352367 Uncertain significance 56,354,813(-) TTCTG(C/T)AGGAA nc-transcript-variant, reference, stop-gained, utr-variant-5-prime
rs111274768 -- 56,346,596(+) GTGTA(C/T)GGTTG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for STAT2 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for STAT2 Gene

Residual Variation Intolerance Score: 7.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STAT2 Gene

Human Gene Mutation Database (HGMD)
STAT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
STAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STAT2 Gene

Disorders for STAT2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for STAT2 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
primary immunodeficiency due to stat2 deficiency
  • primary immunodeficiency with disseminated vaccine-strain measles
mumps
rabies
  • lyssa
skin squamous cell carcinoma
  • epidermoid skin carcinoma
avian influenza
  • avian flu
- elite association - COSMIC cancer census association via MalaCards
Search STAT2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

STAT2_HUMAN
  • Immunodeficiency 44 (IMD44) [MIM:616636]: An autosomal recessive disorder characterized by increased susceptibility to viral infection, resulting in some patients in encephalopathy and infection-associated neurologic decompensation. {ECO:0000269 PubMed:23391734, ECO:0000269 PubMed:26122121}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STAT2

Genetic Association Database (GAD)
STAT2
Human Genome Epidemiology (HuGE) Navigator
STAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
STAT2
genes like me logo Genes that share disorders with STAT2: view

No data available for Genatlas for STAT2 Gene

Publications for STAT2 Gene

  1. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. (PMID: 7885841) Yan R. … Darnell J.E. Jr. (Nucleic Acids Res. 1995) 2 3 4 22 64
  2. Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. (PMID: 18701593) Huh Y.H. … Ahn J.H. (J. Virol. 2008) 3 4 22 64
  3. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 4 22 64
  4. Arginine/lysine-rich structural element is involved in interferon- induced nuclear import of STATs. (PMID: 11150296) Melen K. … Julkunen I. (J. Biol. Chem. 2001) 3 4 22 64
  5. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. (PMID: 9020188) Bluyssen H.A. … Levy D.E. (J. Biol. Chem. 1997) 3 4 22 64

Products for STAT2 Gene

Sources for STAT2 Gene

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