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Aliases for SP1 Gene

Aliases for SP1 Gene

  • Sp1 Transcription Factor 2 3
  • Specificity Protein 1 2
  • TSFP1 4

External Ids for SP1 Gene

Summaries for SP1 Gene

Entrez Gene Summary for SP1 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for SP1 Gene

SP1 (Sp1 Transcription Factor) is a Protein Coding gene. Diseases associated with SP1 include dengue disease and hailey-hailey disease. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for SP1 Gene

  • Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

Gene Wiki entry for SP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SP1 Gene

Genomics for SP1 Gene

Genomic Location for SP1 Gene

Start:
53,380,176 bp from pter
End:
53,416,446 bp from pter
Size:
36,271 bases
Orientation:
Plus strand

Genomic View for SP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SP1 Gene

Regulatory Elements for SP1 Gene

Proteins for SP1 Gene

  • Protein details for SP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08047-SP1_HUMAN
    Recommended name:
    Transcription factor Sp1
    Protein Accession:
    P08047
    Secondary Accessions:
    • E4Z9M7
    • G5E9M8
    • Q86TN8
    • Q9H3Q5
    • Q9NR51
    • Q9NY21
    • Q9NYE7

    Protein attributes for SP1 Gene

    Size:
    785 amino acids
    Molecular mass:
    80693 Da
    Quaternary structure:
    • Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1 (By similarity). Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1.
    Miscellaneous:
    • In the hepatoma cell line Hep-G2, SP1 precursor mRNA may undergo homotype trans-splicing leading to the duplication of exons 2 and 3
    SequenceCaution:
    • Sequence=AAH43224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SP1 Gene

    Alternative splice isoforms for SP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SP1 Gene

Proteomics data for SP1 Gene at MOPED

Post-translational modifications for SP1 Gene

  • Acetylated. Acetylation/deacetylation events affect transcriptional activity. Deacetylation leads to an increase in the expression the 12(s)-lipooxygenase gene though recruitment of p300 to the promoter.
  • O-glycosylated; Contains 8 N-acetylglucosamine side chains. Levels are controlled by insulin and the SP1 phosphorylation states. Insulin-mediated O-glycosylation locates SP1 to the nucleus, where it is sequentially deglycosylated and phosphorylated. O-glycosylation affects transcriptional activity through disrupting the interaction with a number of transcription factors including ELF1 and NFYA. Also inhibits interaction with the HIV1 promoter. Inhibited by peroxisomome proliferator receptor gamma (PPARgamma)
  • Phosphorylated on multiple serine and threonine residues. Phosphorylation is coupled to ubiquitination, sumoylation and proteolytic processing. Phosphorylation on Ser-59 enhances proteolytic cleavage. Phosphorylation on Ser-7 enhances ubiquitination and protein degradation. Hyperphosphorylation on Ser-101 in response to DNA damage has no effect on transcriptional activity. MAPK1/MAPK3-mediated phosphorylation on Thr-453 and Thr-739 enhances VEGF transcription but, represses FGF2-triggered PDGFR-alpha transcription. Also implicated in the repression of RECK by ERBB2. Hyperphosphorylated on Thr-278 and Thr-739 during mitosis by MAPK8 shielding SP1 from degradation by the ubiquitin-dependent pathway. Phosphorylated in the zinc-finger domain by calmodulin-activated PKCzeta. Phosphorylation on Ser-641 by PKCzeta is critical for TSA-activated LHR gene expression through release of its repressor, p107. Phosphorylation on Thr-668, Ser-670 and Thr-681 is stimulated by angiotensin II via the AT1 receptor inducing increased binding to the PDGF-D promoter. This phosphorylation is increased in injured artey wall. Ser-59 and Thr-681 can both be dephosphorylated by PP2A during cell-cycle interphase. Dephosphorylation on Ser-59 leads to increased chromatin association during interphase and increases the transcriptional activity. On insulin stimulation, sequentially glycosylated and phosphorylated on several C-terminal serine and threonine residues.
  • Proteolytic cleavage in the N-terminal repressor domain is prevented by sumoylation. The C-terminal cleaved product is susceptible to degradation
  • Sumoylated with SUMO1. Sumoylation modulates proteolytic cleavage of the N-terminal repressor domain. Sumoylation levels are attenuated during tumorigenesis. Phosphorylation mediates SP1 desumoylation
  • Ubiquitinated. Ubiquitination occurs on the C-terminal proteolytically-cleaved peptide and is triggered by phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser491, Ser612, Thr640, Ser641, Ser698, and Ser702

Other Protein References for SP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SP1 Gene

Domains for SP1 Gene

Gene Families for SP1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • SP :Specificity protein transcription factors

Protein Domains for SP1 Gene

UniProtKB/Swiss-Prot:

SP1_HUMAN
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • P08047
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • P08047
genes like me logo Genes that share domains with SP1: view

Function for SP1 Gene

Molecular function for SP1 Gene

GENATLAS Biochemistry: transcription factor Sp-1,GT box binding protein
UniProtKB/Swiss-Prot Function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.
UniProtKB/Swiss-Prot Induction: By insulin.

Gene Ontology (GO) - Molecular Function for SP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0000987 core promoter proximal region sequence-specific DNA binding --
GO:0001046 core promoter sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with SP1: view
genes like me logo Genes that share phenotypes with SP1: view
Targeting motifs for SP1 Gene
HOMER Transcription Factor Regulatory Elements motif SP1
  • Consensus sequence: GGCCCCGCCCCC Submotif: canonical Cell Type: NA

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for SP1 Gene

Localization for SP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SP1 Gene

Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SP1 Gene COMPARTMENTS Subcellular localization image for SP1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 12169688
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0032993 protein-DNA complex IEA --
genes like me logo Genes that share ontologies with SP1: view

Pathways for SP1 Gene

genes like me logo Genes that share pathways with SP1: view

Gene Ontology (GO) - Biological Process for SP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001701 in utero embryonic development --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0001889 liver development IEA --
GO:0001892 embryonic placenta development IEA --
genes like me logo Genes that share ontologies with SP1: view

Compounds for SP1 Gene

(1) HMDB Compounds for SP1 Gene

Compound Synonyms Cas Number PubMed IDs
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9

(128) Novoseek inferred chemical compound relationships for SP1 Gene

Compound -log(P) Hits PubMed IDs
mithramycin 91.2 101
wp631 81.3 8
5-aza-2deoxycytidine 67.2 14
chloramphenicol 66.9 13
zinc 61.6 136
genes like me logo Genes that share compounds with SP1: view

Transcripts for SP1 Gene

Unigene Clusters for SP1 Gene

Sp1 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for SP1 Gene

GeneLoc Exon Structure for
SP1
ECgene alternative splicing isoforms for
SP1

Expression for SP1 Gene

mRNA expression in normal human tissues for SP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SP1 Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SP1 Gene

SOURCE GeneReport for Unigene cluster for SP1 Gene Hs.649191

mRNA Expression by UniProt/SwissProt for SP1 Gene

P08047-SP1_HUMAN
Tissue specificity: Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.
genes like me logo Genes that share expressions with SP1: view

Orthologs for SP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SP1 36
  • 99.7 (n)
  • 100 (a)
SP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SP1 36
  • 94.1 (n)
  • 95.92 (a)
SP1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SP1 36
  • 94.09 (n)
  • 96.94 (a)
SP1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sp1 36
  • 92.34 (n)
  • 95.64 (a)
Sp1 16
Sp1 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sp1 36
  • 92.77 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves SP1 36
  • 74.69 (n)
  • 81.96 (a)
SP1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SP1 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76006 36
sp1 36
  • 68.28 (n)
  • 71.57 (a)
zebrafish
(Danio rerio)
Actinopterygii sp1 36
  • 65.15 (n)
  • 65.82 (a)
sp1 37
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spps 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sptf-3 37
  • 32 (a)
OneToMany
Species with no ortholog for SP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SP1 Gene

ENSEMBL:
Gene Tree for SP1 (if available)
TreeFam:
Gene Tree for SP1 (if available)

Paralogs for SP1 Gene

genes like me logo Genes that share paralogs with SP1: view

Variants for SP1 Gene

Sequence variations from dbSNP and Humsavar for SP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs784880 -- 53,380,985(+) tcgct(C/G)ttgtt intron-variant, upstream-variant-2KB
rs784881 -- 53,406,070(+) ctttt(C/T)ttttt intron-variant
rs784882 -- 53,406,111(+) ctgtc(A/G)cccag intron-variant
rs784883 -- 53,406,348(+) acagg(C/T)gtgaa intron-variant
rs2045471 -- 53,398,480(-) CATGG(C/T)GAAAC intron-variant

Relevant External Links for SP1 Gene

HapMap Linkage Disequilibrium report
SP1

No data available for Structural Variations from Database of Genomic Variants (DGV) for SP1 Gene

Disorders for SP1 Gene

(1) University of Copenhagen DISEASES for SP1 Gene

(93) Novoseek inferred disease relationships for SP1 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 53.8 3
tumors 50.3 144
retinoblastoma 47.8 26
immunodeficiency 47.3 48
cancer 42.7 58

Relevant External Links for SP1

Genetic Association Database (GAD)
SP1
Human Genome Epidemiology (HuGE) Navigator
SP1
genes like me logo Genes that share disorders with SP1: view

No data available for UniProtKB/Swiss-Prot for SP1 Gene

Publications for SP1 Gene

  1. The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7. (PMID: 1662663) Szpirer J. … DeLuca H.F. (Genomics 1991) 2 3 23
  2. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. (PMID: 8626793) Parks C.L. … Shenk T. (J. Biol. Chem. 1996) 3 4 23
  3. Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition. (PMID: 9065444) Narayan V.A. … Caradonna J.P. (J. Biol. Chem. 1997) 3 4 23
  4. Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression of transcription of the luteinizing hormone receptor gene. (PMID: 16943418) Zhang Y. … Dufau M.L. (Mol. Cell. Biol. 2006) 3 4 23
  5. Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase. (PMID: 18171990) Olofsson B.A. … Azizkhan-Clifford J. (Mol. Cancer Res. 2007) 3 4 23

Products for SP1 Gene

  • Addgene plasmids for SP1

Sources for SP1 Gene

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