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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SZT2 Gene

protein-coding   GIFtS: 40
GCID: GC01P043890

Seizure Threshold 2 Homolog (Mouse)

(Previous names: chromosome 1 open reading frame 84, KIAA0467)
(Previous symbols: C1orf84, KIAA0467)
  Search for SZT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Seizure Threshold 2 Homolog (Mouse)1 2     Seizure Threshold 2 Homolog B (Mouse)1
C1orf841 2 3     RP11-506B15.32
KIAA04671 2 3     SZT2A2
Seizure Threshold 2 Protein Homolog2 3     SZT2B2
Chromosome 1 Open Reading Frame 841     Protein SZT22
Seizure Threshold 2 Homolog A (Mouse)1     

External Ids:    HGNC: 290401   Entrez Gene: 233342   Ensembl: ENSG000001981987   UniProtKB: Q5T0113   

Export aliases for SZT2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SZT2 Gene:
The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as
well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative
stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD
activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance
epileptogenesis. (provided by RefSeq, Jun 2011)

GeneCards Summary for SZT2 Gene: 
SZT2 (seizure threshold 2 homolog (mouse)) is a protein-coding gene. GO annotations related to this gene include molecular_function.

UniProtKB/Swiss-Prot: SZT2_HUMAN, Q5T011
Function: Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective
effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and
confer low seizure threshold (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SZT2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SZT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SZT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

SZT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SZT2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P043890:  view genomic region     (about GC identifiers)

Start:
43,855,553 bp from pter      End:
43,919,918 bp from pter
Size:
64,366 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SZT2_HUMAN, Q5T011 (See protein sequence)
Recommended Name: Protein SZT2  
Size: 3432 amino acids; 378029 Da
Subcellular location: Peroxisome (By similarity)
Sequence caution: Sequence=AAH52802.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI51233.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15649.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03755.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=BAC86771.1; Type=Miscellaneous discrepancy; Note=Probable
cloning artifact; Sequence=BF926328; Type=Frameshift; Positions=Several; Sequence=BF926328; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=BU101724;
Type=Frameshift; Positions=287; Sequence=CAI14886.2; Type=Erroneous gene model prediction; Sequence=CAI23384.1;
Type=Erroneous gene model prediction;
Secondary accessions: A0PJK5 A7E2X4 O75055 Q5JUY7 Q5T012 Q5XKC7 Q6ZNI8 Q6ZT24 Q7Z636 Q8NAY9
Q9H5H7 Q9UFQ8
Alternative splicing: 4 isoforms:  Q5T011-1   Q5T011-4   Q5T011-5   Q5T011-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SZT2: NX_Q5T011

Explore proteomics data for SZT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T011

  • SZT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SZT2 Protein Expression
    REFSEQ proteins: NP_056099.3  
    ENSEMBL proteins: 
     ENSP00000361528   ENSP00000386070   ENSP00000457168   ENSP00000312234   ENSP00000361519  

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    Cloud-Clone Corp. Proteins for SZT2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005777peroxisome IEA--

    SZT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T011


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SZT2_HUMAN, Q5T011
    Function: Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective
    effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and
    confer low seizure threshold (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    SZT2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SZT2:
     Downregulation of NF-kappaB pa  Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Szt2):
     behavior/neurological  integument  mortality/aging  nervous system  pigmentation 

    SZT2 for phenotypes           About GeneDecksing

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    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SZT2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SZT2

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IEA--
    GO:0008150biological_process ND--
    GO:0009791post-embryonic development IEA--
    GO:0043473pigmentation IEA--

    SZT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SZT2

    Search CenterWatch for drugs/clinical trials and news about SZT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SZT2 gene (4 alternative transcripts): 
    NM_015284.3  NM_001012960.1  NM_001012961.1  NM_182518.2  

    Unigene Cluster for SZT2:

    Seizure threshold 2 homolog (mouse)
    Hs.643560  [show with all ESTs]
    Unigene Representative Sequence: NM_015284
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372450(uc001cjh.3) ENST00000357658 ENST00000406439(uc001cji.1)
    ENST00000562955(uc009vws.1 uc001cjk.2) ENST00000470139 ENST00000478140
    ENST00000470897 ENST00000471177 ENST00000460536(uc001cjl.2) ENST00000310739
    ENST00000372442
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): SZT2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB007936.2 AK001249.2 AK027078.1 AK126972.1 AL117402.1 BC017576.1 BC041069.1 BC051343.1 
    BC052802.1 BC082968.1 BC151232.1 

    17 DOTS entries:

    DT.92447357  DT.75101610  DT.75101209  DT.92068022  DT.40197185  DT.100014434  DT.40257700  DT.92447359 
    DT.100774763  DT.121362202  DT.121362286  DT.91687161  DT.91745030  DT.102842726  DT.95238919  DT.95266780 
    DT.99930908 

    24/227 AceView cDNA sequences (see all 227):

    BM562023 BQ952043 NM_015284 BI003868 BM914302 AA938452 AB007936 C15468 
    AI701486 AI657111 AA731490 AW196912 AU124431 BU528173 BU527625 BC051343 
    BC052802 BM453693 AK027078 CA450365 BX112506 BF525944 BC041069 AK131107 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SZT2 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 32b ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SZT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SZT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGGCAT
    SZT2 Expression
    About this image


    See SZT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SZT2

    SOURCE GeneReport for Unigene cluster: Hs.643560

    UniProtKB/Swiss-Prot: SZT2_HUMAN, Q5T011
    Tissue specificity: Expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal
    root ganglia

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SZT2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Szt21 , 5 seizure threshold 21, 5 87.4(n)1
    91.97(a)1
      4 (54.61 cM)5
    2306761  NM_198170.41  NP_937813.31 
     1183627435 
    chicken
    (Gallus gallus)
    Aves SZT26
    Uncharacterized protein
    60(a)
    1 ↔ 1
    8(18617327-18670902)
    lizard
    (Anolis carolinensis)
    Reptilia SZT26
    seizure threshold 2 homolog (mouse)
    58(a)
    1 ↔ 1
    4(107378601-107445024)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5719861 protein SZT2-like 58.66(n)
    55.39(a)
      571986  XM_695635.5  XP_700727.5 
    worm
    (Caenorhabditis elegans)
    Secernentea F54B3.16
    Protein F54B3.1, isoform a
    16(a)
    1 ↔ 1
    II(10251266-10268175)


    ENSEMBL Gene Tree for SZT2 (if available)
    TreeFam Gene Tree for SZT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1687 SNPs in SZT2 are shown (see all 1687)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004538521,2
    Cuntested143987576(+) TGTGTC/G/TGCCCC 2 S W mis11EU 1315
    rs1390271711,2
    C,Funtested143987582(+) GCCCCC/TGGGAG 2 P L mis12Minor allele frequency- T:0.00NA EU 5875
    rs1860433381,2
    --41976886(+) ACTCCA/GTCTCA 1 -- int10--------
    rs728819671,2
    C,F--43858297(+) AGCCAG/AATAGT 1 -- int12Minor allele frequency- A:0.03WA 120
    rs728819721,2
    C,F--43860359(+) AGCCTC/GACCAG 1 -- int13Minor allele frequency- G:0.08WA EA 240
    rs1131686001,2
    C,F--43879269(+) CATATG/ATACAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs355331731,2
    C--43879396(+) TATTT-/ATTT  
            
    GTGAG
    1 -- int10--------
    rs124081121,2
    C,H--43879576(+) actgaC/Ttacag 1 -- int10--------
    rs344643081,2
    C--43911163(+) GCCAT-/CCCCCCC 1 -- int10--------
    rs1149128961,2
    F--43932325(+) AGAGAA/TGTCAA 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for SZT2 (43855553 - 43919918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SZT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747586CNV Deletion23290073
    esv3099CNV Deletion18987735
    esv2400702CNV Deletion18987734
    esv2747597CNV Deletion23290073
    esv2560782CNV Deletion19546169
    nsv527798CNV Loss19592680
    nsv159253CNV Loss16902084
    nsv438377CNV Loss16468122
    esv5810CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SZT2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SZT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Bridging expressed sequence alignments through targeted cDNA sequencing. (PubMed id 15028280)1, 2 Xie H....Gill-More R. (2004)
    6. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1, 2 Dias Neto E....Simpson A.J.G. (2000)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A novel giant peroxisomal superoxide dismutase motif- containing protein. (PubMed id 20045724)2 Toutzaris D....Methner A. (2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PubMed id 16712842)1 Chen L. and Madura K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23334 HGNC: 29040 AceView: KIAA0467 Ensembl:ENSG00000198198 euGenes: HUgn23334
    ECgene: SZT2 H-InvDB: SZT2

    (According to HUGE)
    About This Section
    HUGE: KIAA0467

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SZT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SZT2 gene:
    Search GeneIP for patents involving SZT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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