SZRD1 Gene
protein-coding GIFtS: 36
GCID: GC01P016681
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|
SUZ RNA binding domain containing 1(Previous name: chromosome 1 open reading frame 144 )
(Previous symbol: C1orf144)
| |
Aliases
for SZRD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SUZ RNA Binding Domain Containing 11 2 | | Chromosome 1 Open Reading Frame 1441 | | C1orf1441 2 3 | | Putative MAPK Activating Protein PM20,PM212 | | Putative MAPK-Activating Protein PM18/PM20/PM222 3 | | SUZ Domain-Containing Protein 12 | | DKFZp566C04241 | | UPF0485 Protein C1orf1442 |
Export aliases for SZRD1 gene to outside databases |
Summaries
for SZRD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SZRD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SZRD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SZRD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SZRD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13SZRD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P016681: view genomic region
(about GC identifiers)
Start:
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16,679,070 bp from pter |
End:
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16,724,640 bp from pter |
Size:
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45,571 bases |
Orientation:
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plus strand |
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Proteins
for SZRD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SZRD1_HUMAN, Q7Z422 (See
protein sequence)Recommended Name: SUZ domain-containing protein 1 Size: 152 amino acids; 16997 Da
Sequence caution: Sequence=CAB43245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAC82500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MXJ2 Q7Z424 Q8IVM2 Q8TBV3 Q9Y403Alternative splicing: 4 isoforms: Q7Z422-1 Q7Z422-2 Q7Z422-3 Q7Z422-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SZRD1: NX_Q7Z422
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z422
SZRD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_056424.1 NP_001108072.1 NP_001258798.1
ENSEMBL proteins: ENSP00000383866 ENSP00000419589 ENSP00000383867 ENSP00000420441 ENSP00000418012 ENSP00000364740
Human Recombinant Protein Products:
SZRD1 Antibody Products:
Assay Products for SZRD1: |
Protein
Domains /
Families
for SZRD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SZRD1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z422ProtoNet protein and cluster: Q7Z422 UniProtKB/Swiss-Prot: SZRD1_HUMAN, Q7Z422Similarity: Belongs to the SZRD1 familySimilarity: Contains 1 SUZ domain |
Function
for SZRD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SZRD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SZRD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SZRD1 |
2 GenomeRNAi human phenotypes for SZRD1:
|
Pathways & Interactions
for SZRD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SZRD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SZRD1 (ENSP000003838664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SZRD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SZRD1
Search CenterWatch for drugs/clinical trials and news about SZRD1
|
Transcripts
for SZRD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SZRD1 gene (3 alternative transcripts): NM_015609.3 NM_001114600.2 NM_001271869.1 Unigene Cluster for SZRD1: SUZ RNA binding domain containing 1 Hs.252967 [show with all ESTs]Unigene Representative Sequence: NR_07350111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475078 ENST00000401088(uc010ocb.1 uc001aym.4 uc001ayi.4 uc001ayk.4)
ENST00000471507 ENST00000401089 ENST00000486763 ENST00000476423 ENST00000475554
ENST00000472351 ENST00000492354 ENST00000472461 ENST00000375590
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SZRD1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SZRD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SZRD1 |
Additional cDNA sequence: AB097042.1 AB097043.1 AB097044.1 AB097045.1 AB097046.1 AJ295987.1 AK098272.1 AK297926.1 AK298576.1 AK308787.1 AK316205.1 AL050028.1 AL832937.1 BC010631.1 BC023988.1 BC065538.1 BX640985.1 NR_073500.1 NR_073501.1 NR_073502.1 NR_073503.1 24/29 DOTS entries (see all 29): DT.100822801 DT.100822795 DT.97855332 DT.75137900 DT.97855335 DT.100822786 DT.100822805 DT.100822807 DT.100822794 DT.121345400 DT.100822787 DT.121345446 DT.95180812 DT.121345461 DT.100822803 DT.101975885 DT.121345502 DT.121345545 DT.92460136 DT.121345398 DT.121345432 DT.121345452 DT.121345474 DT.92460133 24/597 AceView cDNA sequences (see all 597): AA657993 BM682496 BU859573 CR614958 CF131261 NM_015609 AB097046 AW674863 CD743164 CR601391 AW207372 AI868983 F16936 BQ672011 CR619226 AI460109 BM915361 BP364894 AW026083 BU930864 BM807120 BQ435242 BQ691732 BM456942
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SZRD1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
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| SP1: | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SZRD1
|
Expression
for SZRD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See SZRD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SZRD1
SOURCE GeneReport for Unigene cluster: Hs.252967
SABiosciences Custom PCR Arrays for SZRD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SZRD1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SZRD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SZRD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SZRD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SZRD1 |
Orthologs
for SZRD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SZRD1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Szrd11 , 5 |
DNA segment, Chr 4, ERATO Doi 22, expressed5
SUZ RNA binding domain containing 11 |
94.96(n)1
97.37(a)1 |
|
4 (73.38 cM)5
2134911 NM_001025608.11 NP_001020779.11
1411130015 |
chicken
(Gallus gallus) |
Aves |
SZRD11 |
chromosome 21 open reading frame, human C1orf144 |
85.96(n)
93.42(a) |
|
419462 NM_001030880.1 NP_001026051.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.36492 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.68(n) |
|
CA789767.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb15h052 |
Transcribed sequence with weak similarity to protein more |
81.24(n) |
|
CB355995.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG319086 |
-- |
12(a) |
1 ↔ 1 |
2L(7024825-7027295) |
ENSEMBL Gene Tree for SZRD1 (if available)
TreeFam Gene Tree for SZRD1 (if available) |
Paralogs
for SZRD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SZRD1 gene
SZRD1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SZRD1
PGOHUM00000258632 PGOHUM00000243695
|
Genomic Variants
for SZRD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SZRD1 (16679070 - 16724640 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SZRD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SZRD1 |
|
Disorders
/ Diseases
for SZRD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SZRD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SZRD1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with SZRD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2, 3 Matsuda A....Sugano S. (2003)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for SZRD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SZRD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SZRD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SZRD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SZRD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SZRD1 gene:
Search GeneIP for patents involving SZRD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SZRD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SZRD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SZRD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SZRD1 | | | OriGene Protein Over-expression Lysate for SZRD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SZRD1 | | OriGene 3'-UTR Clone for SZRD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SZRD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SZRD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SZRD1 | | OriGene Custom Protein Services for SZRD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SZRD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SZRD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SZRD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SZRD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SZRD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SZRD1 |
| |
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| | | | Search Tocris compounds for SZRD1 |
| |  |  |  |  | | | | |
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 |
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 | | | SZRD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SZRD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SZRD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SZRD1 |
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