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Aliases for SZRD1 Gene

Aliases for SZRD1 Gene

  • SUZ RNA Binding Domain Containing 1 2 3 5
  • Putative MAPK-Activating Protein PM18/PM20/PM22 3 4
  • C1orf144 3 4
  • Putative MAPK Activating Protein PM20,PM21 3
  • Chromosome 1 Open Reading Frame 144 2
  • SUZ Domain-Containing Protein 1 3
  • UPF0485 Protein C1orf144 3

External Ids for SZRD1 Gene

Previous HGNC Symbols for SZRD1 Gene

  • C1orf144

Previous GeneCards Identifiers for SZRD1 Gene

  • GC01P016681

Summaries for SZRD1 Gene

GeneCards Summary for SZRD1 Gene

SZRD1 (SUZ RNA Binding Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SZRD1 Gene

Genomics for SZRD1 Gene

Regulatory Elements for SZRD1 Gene

Enhancers for SZRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G016247 1.6 Ensembl ENCODE dbSUPER 11.4 -103.7 -103746 3.5 PKNOX1 CREB3L1 ARNT FEZF1 YY1 ZNF766 FOS KLF13 REST ZNF592 ARHGEF19 RSG1 FBLIM1 SZRD1 FBXO42 ARHGEF19-AS1 SPEN CROCCP2 EIF1AXP1 MT1XP1
GH01G015825 1.2 Ensembl ENCODE dbSUPER 5.6 -526.7 -526675 1.0 KLF1 TFAP4 SAP130 SIN3A ZNF384 ZIC2 TEAD3 ZNF335 FOSL1 PRDM10 FLJ37453 SPEN ENSG00000233078 CLCNKA HSPB7 ARHGEF19 SZRD1 C1orf64 RPS16P1 UQCRHL
GH01G015947 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.5 -401.4 -401397 7.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS DEK ZNF263 HSPB7 CLCNKA PLEKHM2 ZBTB17 LINC01772 ENSG00000233078 SPEN FBLIM1 C1orf64 CLCNKB
GH01G016250 0.4 ENCODE 11.4 -101.8 -101835 0.2 MYNN HNF4A SZRD1 FBXO42 ARHGEF19-AS1 ARHGEF19 GC01M016252 PIR51330 PIR57319
GH01G015961 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2 -388.0 -387979 5.8 HDGF PKNOX1 YBX1 ZNF121 ZNF143 FOS JUNB TBX21 NBN STAT3 CLCNKA PLEKHM2 ZBTB17 CLCNKB CASP9 SZRD1 SPEN ENSG00000234607 GC01P015946
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SZRD1 on UCSC Golden Path with GeneCards custom track

Promoters for SZRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002053 -775 2001 CREB3L1 AGO1 FEZF1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 GLIS1

Genomic Location for SZRD1 Gene

Chromosome:
1
Start:
16,352,575 bp from pter
End:
16,398,148 bp from pter
Size:
45,574 bases
Orientation:
Plus strand

Genomic View for SZRD1 Gene

Genes around SZRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SZRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SZRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SZRD1 Gene

Proteins for SZRD1 Gene

  • Protein details for SZRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z422-SZRD1_HUMAN
    Recommended name:
    SUZ domain-containing protein 1
    Protein Accession:
    Q7Z422
    Secondary Accessions:
    • A8MXJ2
    • C9K0U0
    • Q7Z424
    • Q8IVM2
    • Q8TBV3
    • Q9Y403

    Protein attributes for SZRD1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16997 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB43245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82500.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SZRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SZRD1 Gene

Post-translational modifications for SZRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SZRD1 Gene

No data available for DME Specific Peptides for SZRD1 Gene

Domains & Families for SZRD1 Gene

Protein Domains for SZRD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SZRD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z422

UniProtKB/Swiss-Prot:

SZRD1_HUMAN :
  • Belongs to the SZRD1 family.
Family:
  • Belongs to the SZRD1 family.
genes like me logo Genes that share domains with SZRD1: view

No data available for Gene Families for SZRD1 Gene

Function for SZRD1 Gene

Phenotypes for SZRD1 Gene

genes like me logo Genes that share phenotypes with SZRD1: view

Animal Model Products

miRNA for SZRD1 Gene

miRTarBase miRNAs that target SZRD1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SZRD1 Gene

Localization for SZRD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SZRD1 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SZRD1 Gene

Pathways & Interactions for SZRD1 Gene

SuperPathways for SZRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SZRD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SZRD1 Gene

Drugs & Compounds for SZRD1 Gene

No Compound Related Data Available

Transcripts for SZRD1 Gene

Unigene Clusters for SZRD1 Gene

SUZ RNA binding domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SZRD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for SZRD1 Gene

GeneLoc Exon Structure for
SZRD1
ECgene alternative splicing isoforms for
SZRD1

Expression for SZRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SZRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SZRD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.0), Heart (11.1), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SZRD1 Gene



Protein tissue co-expression partners for SZRD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SZRD1 Gene:

SZRD1

SOURCE GeneReport for Unigene cluster for SZRD1 Gene:

Hs.252967

Evidence on tissue expression from TISSUES for SZRD1 Gene

  • Nervous system(4.5)
  • Skin(3.7)
  • Lung(3.6)
  • Kidney(3)
  • Eye(2.6)
  • Pancreas(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SZRD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SZRD1 Gene

Orthologs for SZRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SZRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SZRD1 34
  • 100 (n)
C1ORF144 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SZRD1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SZRD1 34 35
  • 96.05 (n)
rat
(Rattus norvegicus)
Mammalia Szrd1 34
  • 95.39 (n)
cow
(Bos Taurus)
Mammalia SZRD1 34 35
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Szrd1 34 16 35
  • 94.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SZRD1 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SZRD1 35
  • 93 (a)
OneToOne
C21H1ORF144 34
  • 85.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia szrd1 34
  • 76.32 (n)
MGC76116 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3649 34
zebrafish
(Danio rerio)
Actinopterygii szrd1 34 35
  • 64.25 (n)
wufb15h05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9729 34
Species where no ortholog for SZRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SZRD1 Gene

ENSEMBL:
Gene Tree for SZRD1 (if available)
TreeFam:
Gene Tree for SZRD1 (if available)

Paralogs for SZRD1 Gene

Pseudogenes.org Pseudogenes for SZRD1 Gene

genes like me logo Genes that share paralogs with SZRD1: view

No data available for Paralogs for SZRD1 Gene

Variants for SZRD1 Gene

Sequence variations from dbSNP and Humsavar for SZRD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000070632 -- 16,386,290(+) GCCTC(-/T)TAACA intron-variant
rs1000098392 -- 16,375,118(+) TGATC(C/T)GCCCG intron-variant
rs1000144057 -- 16,374,938(+) AGTGG(C/T)GCAAT intron-variant
rs1000157345 -- 16,371,051(+) GAATA(C/G)CCTAC intron-variant
rs1000298752 -- 16,380,701(+) GACCT(C/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SZRD1 Gene

Variant ID Type Subtype PubMed ID
esv3585337 CNV gain 21293372
nsv945790 CNV duplication 23825009

Variation tolerance for SZRD1 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SZRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SZRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SZRD1 Gene

Disorders for SZRD1 Gene

Relevant External Links for SZRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SZRD1

No disorders were found for SZRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SZRD1 Gene

Publications for SZRD1 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 2 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for SZRD1 Gene

Sources for SZRD1 Gene

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