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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYTL5 Gene

protein-coding   GIFtS: 56
GCID: GC0XP037865

Synaptotagmin-Like 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin-Like 51 2
Exophilin 91 2
slp52
Synaptotagmin-Like Protein 52
SLP53

External Ids:    HGNC: 155891   Entrez Gene: 941222   Ensembl: ENSG000001470417   UniProtKB: Q8TDW53   

Export aliases for SYTL5 gene to outside databases

Previous GC identifers: GC0XP035998 GC0XP036180 GC0XP036737 GC0XP036924 GC0XP036923 GC0XP037622 GC0XP037750 GC0XP037778 GC0XP035611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYTL5 Gene:
The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique
homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding
site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and
liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Sep 2009)

GeneCards Summary for SYTL5 Gene: 
SYTL5 (synaptotagmin-like 5) is a protein-coding gene. Diseases associated with SYTL5 include pseudohypoaldosteronism, and prostate cancer. GO annotations related to this gene include Rab GTPase binding and metal ion binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: SYTL5_HUMAN, Q8TDW5
Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYTL5 gene promoter:
         HOXA9B   HOXA9   CUTL1   Meis-1b   Evi-1   MEF-2A   Pax-3   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYTL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp21.1

SYTL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP037865:  view genomic region     (about GC identifiers)

Start:
37,865,835 bp from pter      End:
37,988,073 bp from pter
Size:
122,239 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYTL5_HUMAN, Q8TDW5 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 5  
Size: 730 amino acids; 81523 Da
Subunit: Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: A2RRF2
Alternative splicing: 2 isoforms:  Q8TDW5-1   Q8TDW5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL5: NX_Q8TDW5

Explore proteomics data for SYTL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDW5

  • SYTL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYTL5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001156806.1  NP_001156807.1  NP_620135.1  

    ENSEMBL proteins: 
     ENSP00000297875   ENSP00000350657   ENSP00000395220  

    Human Recombinant Protein Products for SYTL5: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for SYTL5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    SYTL5 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SYTL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR018029 C2_membr_targeting
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q8TDW5

    ProtoNet protein and cluster: Q8TDW5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYTL5_HUMAN, Q8TDW5
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    SYTL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL5_HUMAN, Q8TDW5
    Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12051743
    GO:0008270zinc ion binding ----
    GO:0017137Rab GTPase binding IEA--
    GO:0046872metal ion binding IEA--
         
    SYTL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SYTL5:
     Decreased CXCL12 induced migra 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYTL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYTL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYTL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYTL5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL5
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL5 (see all 9):
    hsa-miR-3163 hsa-miR-582-3p hsa-miR-607 hsa-miR-4328 hsa-miR-125a-3p hsa-miR-539 hsa-miR-1305 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYTL5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    2wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)
    wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SYTL5
        wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF)

    1 BioSystems Pathway for SYTL5
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYTL5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for SYTL5 (Q8TDW51, 3 ENSP000002978754) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3AP203363, ENSP000002222564I2D: score=2 STRING: ENSP00000222256
    RAB27AP511593, ENSP000003377614I2D: score=5 STRING: ENSP00000337761
    RAB6AP203403, ENSP000003114494I2D: score=2 STRING: ENSP00000311449
    Rab27aQ9ERI21EBI-2939487,EBI-398172
    Rab3aP630111EBI-2939487,EBI-398393
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--

    SYTL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYTL5

    1 HMDB Compound for SYTL5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about SYTL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYTL5 gene (3 alternative transcripts): 
    NM_001163334.1  NM_001163335.1  NM_138780.2  

    Unigene Cluster for SYTL5:

    Synaptotagmin-like 5
    Hs.662334  [show with all ESTs]
    Unigene Representative Sequence: BX647688
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297875 ENST00000357972(uc004ddu.3 uc004ddv.3) ENST00000456733(uc004ddx.3)

    miRNA
    Products:
         
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL5 (see all 9):
    hsa-miR-3163 hsa-miR-582-3p hsa-miR-607 hsa-miR-4328 hsa-miR-125a-3p hsa-miR-539 hsa-miR-1305 hsa-miR-489
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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    OriGene clones in human, mouse for SYTL5 (see all 15)
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    GenScript: all cDNA clones in your preferred vector (see all 3): SYTL5 (NM_138780)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL5
    Sirion Biotech Customized lentivirus for stable overexpression of SYTL5 
                         Customized lentivirus expression plasmids for stable overexpression of SYTL5 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SYTL5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL5

    Additional mRNA sequence: 

    AB080222.1 AK125106.1 BC131585.1 BX647688.1 

    3 DOTS entries:

    DT.101979722  DT.40119152  DT.121282259 

    7 AceView cDNA sequences:

    AL708101 CD652837 NM_138780 AK125106 AB080222 BX647688 BU177061 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:              -                                                                                                                     
    SP2:              -     -                                                                                                               
    SP3:                    -                                                                                                               


    ECgene alternative splicing isoforms for SYTL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYTL5 expression in normal human tissues (normalized intensities)      SYTL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGTTCATA
    SYTL5 Expression
    About this image


    SYTL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Heart (Cardiovascular System)
             DKK1-induced cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...

    See SYTL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYTL5

    SOURCE GeneReport for Unigene cluster: Hs.662334

    UniProtKB/Swiss-Prot: SYTL5_HUMAN, Q8TDW5
    Tissue specificity: Highly expressed in placenta and liver

        SABiosciences Custom PCR Arrays for SYTL5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYTL5 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl51 , 5 synaptotagmin-like 51, 5 86.06(n)1
    84.55(a)1
      X (4.62 cM)5
    2366431  NM_177704.21  NP_808372.11 
     98856225 
    chicken
    (Gallus gallus)
    Aves LOC4279901 synaptotagmin-like protein 5-like 70.77(n)
    68.94(a)
      427990  XM_003640483.1  XP_003640531.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYTL56
    synaptotagmin-like 5
    64(a)
    1 ↔ 1
    3(132272496-132349089)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986722 hypothetical protein LOC398672 72.82(n)    BC054989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sytl51 synaptotagmin-like 5 58.69(n)
    56.25(a)
      558324  XM_681527.5  XP_686619.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73433 synaptic vesicle endocytosis protein
    transporter
    39(a)   88D4   --


    ENSEMBL Gene Tree for SYTL5 (if available)
    TreeFam Gene Tree for SYTL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYTL5 gene
    SYTL42  SYTL12  SYTL32  SYTL22  
    2 SIMAP similar genes for SYTL5 using alignment to 1 protein entry:     SYTL5_HUMAN:
    SYTL1    SYTL4

    SYTL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1884 SNPs in SYTL5 are shown (see all 1884)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881625211,2
    --37780390(+) AATGAA/GATTCT 2 -- us2k10--------
    rs1913824971,2
    --37780399(+) CTGTCA/GTTTGC 2 -- us2k10--------
    rs1828046251,2
    --37780454(+) GCCAGA/GCACAG 2 -- us2k10--------
    rs78857041,2
    C,F,A,H--37780468(+) aaaaaA/Ttttgc 2 -- us2k1 tfbs35--NA WA 144
    rs1483095011,2
    C--37780687(+) TGTGCA/GTTTTA 2 -- us2k10--------
    rs1912949931,2
    --37780708(+) GACAGC/TATGAT 2 -- us2k10--------
    rs59642781,2
    C,F,H--37780713(+) tatgaT/Ctgtat 2 -- us2k14Minor allele frequency- C:0.01NS EA 404
    rs1835248821,2
    --37780768(+) ATTTAC/TCCTGA 2 -- us2k10--------
    rs1878120011,2
    --37780879(+) AAAACC/TCAGCC 2 -- us2k10--------
    rs1923385081,2
    C--37780907(+) GGAGAC/TAGAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYTL5 (37865835 - 37988073 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SYTL5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518029CNV Gain19592680
    esv2752323CNV Gain17911159
    nsv519012CNV Gain19592680


    Human Gene Mutation Database (HGMD): SYTL5

    Locus Specific Mutation Databases (LSDB): SYTL5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYTL5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for SYTL5:    About MalaCards
    pseudohypoaldosteronism    prostate cancer    prostatitis


    SYTL5 for disorders           About GeneDecksing


    Export disorders for SYTL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYTL5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SYTL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. (PubMed id 12051743)1, 2 Kuroda T.S.... Mikoshiba K. (2002)
    2. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. (PubMed id 16630545)1, 9 Saxena S.K....Fukuda M. (2006)
    3. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)
    4. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PubMed id 12590134)1 Fukuda M. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism. (PubMed id 16762324)9 Saxena S.K. and Kaur S. (2006)
    10. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)9 Holt O....Griffiths G.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 94122 HGNC: 15589 AceView: SYTL5 Ensembl:ENSG00000147041 euGenes: HUgn94122
    ECgene: SYTL5 H-InvDB: SYTL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYTL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYTL5 gene:
    Search GeneIP for patents involving SYTL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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