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Aliases for SYTL5 Gene

Aliases for SYTL5 Gene

  • Synaptotagmin-Like 5 2 3
  • Exophilin 9 2 3
  • Slp5 3 4

External Ids for SYTL5 Gene

Previous GeneCards Identifiers for SYTL5 Gene

  • GC0XP035998
  • GC0XP036180
  • GC0XP036737
  • GC0XP036924
  • GC0XP036923
  • GC0XP037622
  • GC0XP037750
  • GC0XP037778
  • GC0XP037865
  • GC0XP035611
  • GC0XP038006

Summaries for SYTL5 Gene

Entrez Gene Summary for SYTL5 Gene

  • The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for SYTL5 Gene

SYTL5 (Synaptotagmin-Like 5) is a Protein Coding gene. Among its related pathways are wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF) and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for SYTL5 Gene

  • May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL5 Gene

Genomics for SYTL5 Gene

Regulatory Elements for SYTL5 Gene

Genomic Location for SYTL5 Gene

37,906,068 bp from pter
38,129,294 bp from pter
223,227 bases
Plus strand

Genomic View for SYTL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL5 Gene

Proteins for SYTL5 Gene

  • Protein details for SYTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptotagmin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • A2RRF2

    Protein attributes for SYTL5 Gene

    730 amino acids
    Molecular mass:
    81523 Da
    Quaternary structure:
    • Binds RAB27A that has been activated by GTP-binding, and possibly also RAB3A and RAB6A

    Alternative splice isoforms for SYTL5 Gene


neXtProt entry for SYTL5 Gene

Proteomics data for SYTL5 Gene at MOPED

Post-translational modifications for SYTL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYTL5 Gene

Antibody Products

No data available for DME Specific Peptides for SYTL5 Gene

Domains & Families for SYTL5 Gene

Gene Families for SYTL5 Gene

Protein Domains for SYTL5 Gene

Suggested Antigen Peptide Sequences for SYTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 1 FYVE-type zinc finger.
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with SYTL5: view

Function for SYTL5 Gene

Molecular function for SYTL5 Gene

UniProtKB/Swiss-Prot Function:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids

Gene Ontology (GO) - Molecular Function for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 12051743
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYTL5: view
genes like me logo Genes that share phenotypes with SYTL5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYTL5 Gene

Localization for SYTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL5 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for SYTL5 Gene COMPARTMENTS Subcellular localization image for SYTL5 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0070382 exocytic vesicle IBA --
genes like me logo Genes that share ontologies with SYTL5: view

Pathways & Interactions for SYTL5 Gene

genes like me logo Genes that share pathways with SYTL5: view

Pathways by source for SYTL5 Gene

1 GeneGo (Thomson Reuters) pathway for SYTL5 Gene

Gene Ontology (GO) - Biological Process for SYTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYTL5: view

No data available for SIGNOR curated interactions for SYTL5 Gene

Drugs & Compounds for SYTL5 Gene

(1) Drugs for SYTL5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SYTL5: view

Transcripts for SYTL5 Gene

mRNA/cDNA for SYTL5 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYTL5 Gene

Synaptotagmin-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: - -
SP3: -

Relevant External Links for SYTL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYTL5 Gene

mRNA expression in normal human tissues for SYTL5 Gene

mRNA differential expression in normal tissues according to GTEx for SYTL5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.3), Brain - Nucleus accumbens (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Amygdala (x4.6), Brain - Hypothalamus (x4.5), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for SYTL5 Gene

This gene is overexpressed in Nasal epithelium (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYTL5 Gene

SOURCE GeneReport for Unigene cluster for SYTL5 Gene Hs.662334

mRNA Expression by UniProt/SwissProt for SYTL5 Gene

Tissue specificity: Highly expressed in placenta and liver
genes like me logo Genes that share expression patterns with SYTL5: view

Protein tissue co-expression partners for SYTL5 Gene

Primer Products

In Situ Assay Products

Orthologs for SYTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYTL5 35
  • 88.3 (n)
  • 85.81 (a)
SYTL5 36
  • 83 (a)
(Canis familiaris)
Mammalia SYTL5 35
  • 90.2 (n)
  • 89.1 (a)
SYTL5 36
  • 88 (a)
(Mus musculus)
Mammalia Sytl5 35
  • 86.06 (n)
  • 84.55 (a)
Sytl5 16
Sytl5 36
  • 84 (a)
(Pan troglodytes)
Mammalia SYTL5 35
  • 99.56 (n)
  • 99.6 (a)
SYTL5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sytl5 35
  • 85.57 (n)
  • 85.49 (a)
(Monodelphis domestica)
Mammalia SYTL5 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SYTL5 36
  • 69 (a)
(Gallus gallus)
Aves SYTL5 35
  • 71.05 (n)
  • 69.3 (a)
SYTL5 36
  • 76 (a)
(Anolis carolinensis)
Reptilia SYTL5 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl5 35
  • 59.44 (n)
  • 52.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398672 35
(Danio rerio)
Actinopterygii sytl5 35
  • 58.71 (n)
  • 55.64 (a)
sytl5 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7343 37
  • 39 (a)
Species with no ortholog for SYTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL5 Gene

Gene Tree for SYTL5 (if available)
Gene Tree for SYTL5 (if available)

Paralogs for SYTL5 Gene

Paralogs for SYTL5 Gene

(2) SIMAP similar genes for SYTL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYTL5: view

Variants for SYTL5 Gene

Sequence variations from dbSNP and Humsavar for SYTL5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs743150 -- 37,995,436(-) ATCAT(A/G)TGGCA intron-variant
rs761911 -- 37,999,289(+) TTATT(C/T)TAGGA intron-variant
rs761912 -- 38,000,176(+) AGGTC(A/C)TTAGA intron-variant
rs761913 -- 38,000,257(+) AAGGT(G/T)TTCTG intron-variant
rs768935 -- 38,032,688(+) tatgt(A/G)tatat upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL5 Gene

Variant ID Type Subtype PubMed ID
esv2752323 CNV Gain 17911159
nsv518029 CNV Gain 19592680
nsv519012 CNV Gain 19592680

Variation tolerance for SYTL5 Gene

Residual Variation Intolerance Score: 83.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL5 Gene

Disorders for SYTL5 Gene

Relevant External Links for SYTL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SYTL5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL5 Gene

Publications for SYTL5 Gene

  1. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PMID: 18266782) Holt O. … Griffiths G.M. (Traffic 2008) 23 67
  2. Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism. (PMID: 16630545) Saxena S.K. … Fukuda M. (Biochem. Biophys. Res. Commun. 2006) 23 67
  3. Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism. (PMID: 16762324) Saxena S.K. … Kaur S. (Biochem. Biophys. Res. Commun. 2006) 23 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 67

Products for SYTL5 Gene

Sources for SYTL5 Gene

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