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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYTL4 Gene

protein-coding GIFtS: 54
GCID: GC0XM099929

synaptotagmin-like 4

Explore 2 diseases affiliated with
SYTL4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin-Like 4¹ ²		Synaptotagmin-Like Protein 4²
SLP4²		Exophilin-2³
Exophilin-2³		Granuphilin³
Granuphilin-A¹

External Ids:	HGNC: 15588¹	Entrez Gene: 94121²	Ensembl: ENSG00000102362⁷	OMIM: 300723⁵	UniProtKB: Q96C24³

Export aliases for SYTL4 gene to outside databases

Previous GC identifers: GC0XM095211 GC0XM096890 GC0XM097965 GC0XM098701 GC0XM099735 GC0XM089729

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYTL4:

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an

N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases

and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting

dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same

protein. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24

Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.

Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)

Gene Wiki entry for SYTL4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYTL4 gene promoter:
FOXL1 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYTL4 promoter sequence

Search SABiosciences Chromatin IP Primers for SYTL4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq21.33

SYTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM099929: view genomic region (about GC identifiers)

Start:	99,929,488 bp from pter	End:	99,987,135 bp from pter
Size:	57,648 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24 (See protein sequence)

Recommended Name: Synaptotagmin-like protein 4

Size: 671 amino acids; 76024 Da

Subunit: Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active

mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B (By similarity)

Subcellular location: Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein

(By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By similarity).

Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing

vesicles (By similarity)

2 PDB 3D structures from and Proteopedia for SYTL4:

2CSZ (3D)

3FDW (3D)

Secondary accessions: Q5H9J3 Q5JPG8 Q8N9P4 Q9H4R0 Q9H4R1

Alternative splicing: 2 isoforms: Q96C24-1 Q96C24-2 (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL4: NX_Q96C24

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96C24

SYTL4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001123368.1 NP_001167539.1 NP_542775.2

ENSEMBL proteins:

ENSP00000362080 ENSP00000263033 ENSP00000362072 ENSP00000390252 ENSP00000403556

ENSP00000276141

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYTL4

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005768	endosome	IDA	19966785
GO:0005813	centrosome	IDA	--

SYTL4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SYTL4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYTL4 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR001841 Znf_RING

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001565 Synaptotagmin

IPR018029 C2_membr_targeting

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q96C24

ProtoNet protein and cluster: Q96C24

3 Blocks protein families:

IPB000008 C2 domain

IPB001565 Synaptotagmin signature

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24

Similarity: Contains 2 C2 domains

Similarity: Contains 1 FYVE-type zinc finger

Similarity: Contains 1 RabBD (Rab-binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24

Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.

Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SYTL4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL4
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL4 (see all 24):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-539 hsa-miR-106a hsa-miR-885-5p hsa-miR-302e hsa-miR-520a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SYTL4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL4 (see all 7) OriGene shRNA RFP: SYTL4 OriGene siRNA: SYTL4
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Gene Editing
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYTL4
		Search LifeMap BioReagents cell lines for SYTL4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL4

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005543	phospholipid binding	ISS	--
GO:0008270	zinc ion binding	IEA	--
GO:0017137	Rab GTPase binding	IEA	--

SYTL4 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for SYTL4:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Low eccentricity cells

Animal Models:
Mouse knock-out Sytl4^tm1Tiz for SYTL4
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sytl4):

endocrine/exocrine gland

growth/size

homeostasis/metabolism

nervous system

SYTL4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

1.00

1 BioSystems Pathway for SYTL4

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYTL4

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for SYTL4 (Q96C24³ ENSP00000263033⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STXBP1	P61764³, ENSP00000362399⁴	I2D: score=5 STRING: ENSP00000362399
CCDC85B	Q15834³, ENSP00000311695⁴	I2D: score=4 STRING: ENSP00000311695
RAB27B	O00194³, ENSP00000262094⁴	I2D: score=2 STRING: ENSP00000262094
USP20	Q9Y2K6³, ENSP00000313811⁴	I2D: score=2 STRING: ENSP00000313811
RAB27A	P51159³, ENSP00000337761⁴	I2D: score=5 STRING: ENSP00000337761

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006887	exocytosis	IEA	--
GO:0045921	positive regulation of exocytosis	IMP	19966785
GO:0046676	negative regulation of insulin secretion	IEA	--
GO:0050714	positive regulation of protein secretion	IMP	19966785

SYTL4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SYTL4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYTL4

2 DrugBank Compounds for SYTL4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Insulin, porcine	--	9004-14-2	target	--	16831872 16216924 15028737 17016423 17139284
Insulin recombinant	--	9004-10-8	target	--	17139284 17016423

1 Novoseek chemical compound relationship for SYTL4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glucose	17.5	2	18177263 (1), 18397364 (1)

Search CenterWatch for drugs/clinical trials and news about SYTL4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYTL4 gene (3 alternative transcripts):

NM_001129896.2 NM_001174068.1 NM_080737.2

Unigene Cluster for SYTL4:

Synaptotagmin-like 4

Hs.592224 [show with all ESTs]

Unigene Representative Sequence: NM_080737

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372989(uc004egd.4 uc004ege.4 uc004egf.4) ENST00000491602(uc004egc.3)

ENST00000263033 ENST00000372981(uc004egg.4) ENST00000491326 ENST00000455616

ENST00000454200(uc010nnb.3) ENST00000276141(uc010nnc.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL4
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL4 (see all 24):
		hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-539 hsa-miR-106a hsa-miR-885-5p hsa-miR-302e hsa-miR-520a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SYTL4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL4

Additional cDNA sequence:

AF302493.1 AK098473.1 AK292588.1 AK313086.1 BC014913.1 BX537410.1

14 DOTS entries:

DT.75164170 DT.97838291 DT.121288743 DT.100024039 DT.100781864 DT.100710360 DT.313497 DT.95254560

DT.97770414 DT.121288752 DT.91746458 DT.121288742 DT.91650038 DT.95201869

24/78 AceView cDNA sequences (see all 78):

AI362789 BU159587 BC014913 AA573470 BQ435318 BU675401 AA775571 AI367961

NM_080737 AA195747 BX471979 BG398971 BM905943 BQ432309 AA195710 CA422375

BX382206 AL832596 AI278198 AA782876 AW043929 BM467790 BX471789 BU164860

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL4 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20a	·
SP1:																																															-
SP2:					-		-		-																																						-
SP3:					-		-		-		-																																				-
SP4:					-				-
SP5:									-		-								-		-

ExUns:	20b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SYTL4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYTL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTGTGCT

About this image

SYTL4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYTL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYTL4

SOURCE GeneReport for Unigene cluster: Hs.592224

SABiosciences Custom PCR Arrays for SYTL4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYTL4 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SYTL4¹	synaptotagmin-like 4	71.79(n) 70.89(a)		422260 XM_003641076.1 XP_003641124.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18750²	Transcribed sequence with moderate similarity to protein more	75.36(n)		AL970091.2
zebrafish (Danio rerio)	Actinopterygii	zgc:158411¹	zgc:158411	57(n) 51.3(a)		553322 NM_001080988.1 NP_001074457.1
fruit fly (Drosophila melanogaster)	Insecta	CG7343³	synaptic vesicle endocytosis protein transporter	43(a)		88D4 --
worm (Caenorhabditis elegans)	Secernentea	snt-6⁶	SyNapTotagmin family member (snt-6)	19(a)	possible ortholog	II(745469-750171)

ENSEMBL Gene Tree for SYTL4 (if available)
TreeFam Gene Tree for SYTL4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYTL4 gene

DOC2B² SYTL5² SYTL1² DOC2A² SYTL3² RPH3A² SYTL2²

12 SIMAP similar genes for SYTL4 using alignment to 2 protein entries: SYTL4_HUMAN (see all proteins):

CHR11SYT SYTL2 SYTL5 SYT15 SYT1 SYT11

SYTL1 SYT2 RPH3A SYTL3 MYRIP MLPH

SYTL4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144977235^1,2		--	99929071(+)	`AAAAGA/CAAAAG`	3	--	ds500¹ int¹		0	--	--	--	--
rs138910057^1,2		--	99929162(+)	`CATCTA/CTCTCC`	3	--	int¹ ds500¹		0	--	--	--	--
rs189280940^1,2		--	99929259(+)	`TCTCAA/GTGTTC`	3	--	ds500¹ int¹		0	--	--	--	--
rs182020954^1,2		--	99929484(+)	`ACACAA/GACGTT`	3	--	int¹ ds500¹		0	--	--	--	--
rs140612294^1,2		--	99929487(+)	`CAAACA/GTTTGA`	3	--	spd¹ ds500¹		0	--	--	--	--
rs8780^1,2	C,F,A,H,	--	99929532(-)	`ACCCCC/GCTGAC`	3	--	ut3¹		14		MN NS EA NA WA	1218
rs185769832^1,2		--	99929637(+)	`CCATTC/TGGTTC`	3	--	ut3¹		0	--	--	--	--
rs190632064^1,2		--	99929638(+)	`CATTCA/GGTTCA`	3	--	ut3¹		0	--	--	--	--
rs183497469^1,2		--	99929805(+)	`TTGATC/GAATGA`	3	--	ut3¹		0	--	--	--	--
rs186394828^1,2		--	99930085(+)	`TAACAC/TACCCC`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYTL4 (99929488 - 99987135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYTL4: --
Locus Specific Mutation Databases (LSDB): SYTL4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SYTL4 for disorders           About GeneDecksing

OMIM gene information: 300723    OMIM disorders: --

2 diseases for SYTL4:    About MalaCards

hyperglycemia pancreatitis

Export disorders for SYTL4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SYTL4 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with SYTL4)

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MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. (PubMed id 16831872)^{1, 7, 9} Plaisance V....Regazzi R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. (PubMed id 15028737)^{7, 9} Torii S....Izumi T. (2004)
Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. (PubMed id 10497219)^{1, 9} Wang J....Izumi T. (1999)
Rab27a and Rab27b control different steps of the exos ome secretion pathway. (PubMed id 19966785)^{1, 9} Ostrowski M....Thery C. (2010)
Involvement of Rab27b in the regulated secretion of pituitary hormones. (PubMed id 11956164)^{1, 9} Zhao S....Izumi T. (2002)
Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PubMed id 12590134)^{1, 9} Fukuda M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 94121	HGNC: 15588	AceView: SYTL4	Ensembl:ENSG00000102362	euGenes: HUgn94121
ECgene: SYTL4	H-InvDB: SYTL4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYTL4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYTL4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYTL4 gene:
Search GeneIP for patents involving SYTL4

GeneCards and IP:
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synaptotagmin-like 4

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synaptotagmin-like 4

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