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Aliases for SYTL4 Gene

Aliases for SYTL4 Gene

  • Synaptotagmin Like 4 2 3 5
  • Exophilin-2 2 3 4
  • Granuphilin-A 2 3
  • Granuphilin 4
  • SLP4 3

External Ids for SYTL4 Gene

Previous GeneCards Identifiers for SYTL4 Gene

  • GC0XM095211
  • GC0XM096890
  • GC0XM097965
  • GC0XM098701
  • GC0XM099735
  • GC0XM099929
  • GC0XM089729

Summaries for SYTL4 Gene

Entrez Gene Summary for SYTL4 Gene

  • This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for SYTL4 Gene

SYTL4 (Synaptotagmin Like 4) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is SYTL3.

UniProtKB/Swiss-Prot for SYTL4 Gene

  • Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

Gene Wiki entry for SYTL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL4 Gene

Genomics for SYTL4 Gene

Regulatory Elements for SYTL4 Gene

Promoters for SYTL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYTL4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SYTL4 gene promoter:

Genomic Location for SYTL4 Gene

Chromosome:
X
Start:
100,674,491 bp from pter
End:
100,732,148 bp from pter
Size:
57,658 bases
Orientation:
Minus strand

Genomic View for SYTL4 Gene

Genes around SYTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL4 Gene

Proteins for SYTL4 Gene

  • Protein details for SYTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C24-SYTL4_HUMAN
    Recommended name:
    Synaptotagmin-like protein 4
    Protein Accession:
    Q96C24
    Secondary Accessions:
    • Q5H9J3
    • Q5JPG8
    • Q8N9P4
    • Q9H4R0
    • Q9H4R1

    Protein attributes for SYTL4 Gene

    Size:
    671 amino acids
    Molecular mass:
    76024 Da
    Quaternary structure:
    • Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYTL4 Gene

    Alternative splice isoforms for SYTL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL4 Gene

Proteomics data for SYTL4 Gene at MOPED

Post-translational modifications for SYTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYTL4 Gene

Antibody Products

No data available for DME Specific Peptides for SYTL4 Gene

Domains & Families for SYTL4 Gene

Gene Families for SYTL4 Gene

Suggested Antigen Peptide Sequences for SYTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C24

UniProtKB/Swiss-Prot:

SYTL4_HUMAN :
  • Contains 2 C2 domains.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with SYTL4: view

Function for SYTL4 Gene

Molecular function for SYTL4 Gene

UniProtKB/Swiss-Prot Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding ISS --
GO:0005544 calcium-dependent phospholipid binding IBA --
genes like me logo Genes that share ontologies with SYTL4: view
genes like me logo Genes that share phenotypes with SYTL4: view

Animal Models for SYTL4 Gene

MGI Knock Outs for SYTL4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYTL4 Gene

Localization for SYTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL4 Gene

Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL4 Gene COMPARTMENTS Subcellular localization image for SYTL4 gene
Compartment Confidence
cytoskeleton 5
endosome 5
nucleus 5
cytosol 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IBA --
GO:0016324 apical plasma membrane IEA --
GO:0030658 transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYTL4: view

Pathways & Interactions for SYTL4 Gene

genes like me logo Genes that share pathways with SYTL4: view

Pathways by source for SYTL4 Gene

Gene Ontology (GO) - Biological Process for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046676 negative regulation of insulin secretion IEA --
GO:0050714 positive regulation of protein secretion IMP 19966785
GO:0071985 multivesicular body sorting pathway IMP 19966785
genes like me logo Genes that share ontologies with SYTL4: view

No data available for SIGNOR curated interactions for SYTL4 Gene

Drugs & Compounds for SYTL4 Gene

(2) Drugs for SYTL4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Regular Approved, Experimental, Investigational Pharma Target 0
Insulin, porcine Approved Pharma Target 0

(1) Additional Compounds for SYTL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYTL4: view

Transcripts for SYTL4 Gene

Unigene Clusters for SYTL4 Gene

Synaptotagmin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

ExUns: 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SYTL4 Gene

GeneLoc Exon Structure for
SYTL4
ECgene alternative splicing isoforms for
SYTL4

Expression for SYTL4 Gene

mRNA expression in normal human tissues for SYTL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL4 Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for SYTL4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (55.1) and Platelet (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYTL4 Gene



SOURCE GeneReport for Unigene cluster for SYTL4 Gene Hs.592224

genes like me logo Genes that share expression patterns with SYTL4: view

Protein tissue co-expression partners for SYTL4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYTL4 Gene

Orthologs for SYTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL4 36
  • 99 (a)
OneToOne
SYTL4 35
  • 95.18 (n)
  • 93.57 (a)
cow
(Bos Taurus)
Mammalia SYTL4 36
  • 92 (a)
OneToOne
SYTL4 35
  • 91.95 (n)
  • 92.4 (a)
dog
(Canis familiaris)
Mammalia SYTL4 35
  • 93.39 (n)
  • 93.89 (a)
SYTL4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sytl4 16
Sytl4 35
  • 89.52 (n)
  • 90.61 (a)
Sytl4 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYTL4 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYTL4 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sytl4 35
  • 89.62 (n)
  • 91.65 (a)
chicken
(Gallus gallus)
Aves SYTL4 35
  • 71.74 (n)
  • 70.89 (a)
SYTL4 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18750 35
sytl4 35
  • 65.11 (n)
  • 62.99 (a)
zebrafish
(Danio rerio)
Actinopterygii sytl4 36
  • 48 (a)
OneToOne
sytl4 35
  • 56.95 (n)
  • 51.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7343 37
  • 43 (a)
btsz 35
  • 49.74 (n)
  • 45.16 (a)
Species with no ortholog for SYTL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL4 Gene

ENSEMBL:
Gene Tree for SYTL4 (if available)
TreeFam:
Gene Tree for SYTL4 (if available)

Paralogs for SYTL4 Gene

Paralogs for SYTL4 Gene

(14) SIMAP similar genes for SYTL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYTL4: view

Variants for SYTL4 Gene

Sequence variations from dbSNP and Humsavar for SYTL4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs8780 -- 100,674,535(-) ACCCC(A/C/G)CTGAC utr-variant-3-prime
rs2027828 -- 100,703,813(+) ATGAG(G/T)GAAAA intron-variant
rs2858176 -- 100,728,888(+) AAAAG(C/T)TAGCC intron-variant
rs4497115 -- 100,697,882(+) ATTCG(C/T)TAGTA intron-variant
rs4287075 -- 100,684,077(+) ATTGA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL4 Gene

Variant ID Type Subtype PubMed ID
nsv510850 CNV Loss 20534489

Variation tolerance for SYTL4 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL4 Gene

HapMap Linkage Disequilibrium report
SYTL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL4 Gene

Disorders for SYTL4 Gene

Relevant External Links for SYTL4

Genetic Association Database (GAD)
SYTL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL4

No disorders were found for SYTL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL4 Gene

Publications for SYTL4 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. (PMID: 16831872) Plaisance V. … Regazzi R. (J. Biol. Chem. 2006) 3 23 25
  3. Rab27a and Rab27b control different steps of the exosome secretion pathway. (PMID: 19966785) Ostrowski M. … Thery C. (Nat. Cell Biol. 2010) 3 23
  4. Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. (PMID: 15028737) Torii S. … Izumi T. (J. Biol. Chem. 2004) 23 25
  5. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PMID: 12590134) Fukuda M. (J. Biol. Chem. 2003) 3 23

Products for SYTL4 Gene

Sources for SYTL4 Gene

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