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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYTL4 Gene

protein-coding   GIFtS: 58
GCID: GC0XM099929

Synaptotagmin-Like 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin-Like 41 2     Synaptotagmin-Like Protein 42
exophilin-21 2     Exophilin-23
granuphilin-a1 2     Granuphilin3
SLP42     

External Ids:    HGNC: 155881   Entrez Gene: 941212   Ensembl: ENSG000001023627   OMIM: 3007235   UniProtKB: Q96C243   

Export aliases for SYTL4 gene to outside databases

Previous GC identifers: GC0XM095211 GC0XM096890 GC0XM097965 GC0XM098701 GC0XM099735 GC0XM089729


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYTL4 Gene:
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by
an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab
GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in
inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode
the same protein. (provided by RefSeq, Mar 2010)

GeneCards Summary for SYTL4 Gene: 
SYTL4 (synaptotagmin-like 4) is a protein-coding gene. Diseases associated with SYTL4 include hyperglycemia, and pancreatitis. GO annotations related to this gene include phospholipid binding and Rab GTPase binding. An important paralog of this gene is SYTL5.

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24
Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.
Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By
similarity)

Gene Wiki entry for SYTL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYTL4 gene promoter:
         FOXL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYTL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33

SYTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM099929:  view genomic region     (about GC identifiers)

Start:
99,929,488 bp from pter      End:
99,987,135 bp from pter
Size:
57,648 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 4  
Size: 671 amino acids; 76024 Da
Subunit: Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant
active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B (By similarity)
Subcellular location: Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane
protein (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By
similarity). Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with
insulin-containing vesicles (By similarity)
2 PDB 3D structures from and Proteopedia for SYTL4:
2CSZ (3D)        3FDW (3D)    
Secondary accessions: Q5H9J3 Q5JPG8 Q8N9P4 Q9H4R0 Q9H4R1
Alternative splicing: 2 isoforms:  Q96C24-1   Q96C24-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL4: NX_Q96C24

Explore proteomics data for SYTL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96C24

  • SYTL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYTL4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001123368.1  NP_001167539.1  NP_542775.2  

    ENSEMBL proteins: 
     ENSP00000362080   ENSP00000263033   ENSP00000362072   ENSP00000390252   ENSP00000403556  
     ENSP00000276141  

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    Cloud-Clone Corp. Proteins for SYTL4 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IDA19966785
    GO:0005813centrosome IDA--

    SYTL4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR001841 Znf_RING
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96C24

    ProtoNet protein and cluster: Q96C24

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    SYTL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL4_HUMAN, Q96C24
    Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.
    Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By
    similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ISS--
    GO:0008270zinc ion binding IEA--
    GO:0017137Rab GTPase binding IEA--
         
    SYTL4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SYTL4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Low eccentricity cells 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sytl4):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  nervous system 

    SYTL4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sytl4tm1Tiz for SYTL4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYTL4 
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    SwitchGear 3'UTR luciferase reporter plasmidSYTL4 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYTL4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL4
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYTL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for SYTL4 (Q96C243 ENSP000002630334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STXBP1P617643, ENSP000003623994I2D: score=5 STRING: ENSP00000362399
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    RAB27BO001943, ENSP000002620944I2D: score=2 STRING: ENSP00000262094
    USP20Q9Y2K63, ENSP000003138114I2D: score=2 STRING: ENSP00000313811
    RAB27AP511593, ENSP000003377614I2D: score=5 STRING: ENSP00000337761
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0045921positive regulation of exocytosis IMP19966785
    GO:0046676negative regulation of insulin secretion IEA--
    GO:0050714positive regulation of protein secretion IMP19966785

    SYTL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYTL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    2 DrugBank Compounds for SYTL4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--16831872 16216924 15028737 17016423 17139284
    Insulin Regular -- 11061-68-0target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for SYTL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 17.5 2 18177263 (1), 18397364 (1)

    Search CenterWatch for drugs/clinical trials and news about SYTL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SYTL4 gene (3 alternative transcripts): 
    NM_001129896.2  NM_001174068.1  NM_080737.2  

    Unigene Cluster for SYTL4:

    Synaptotagmin-like 4
    Hs.592224  [show with all ESTs]
    Unigene Representative Sequence: NM_080737
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372989(uc004egd.4 uc004ege.4 uc004egf.4) ENST00000491602(uc004egc.3)
    ENST00000263033 ENST00000372981(uc004egg.4) ENST00000491326 ENST00000455616
    ENST00000454200(uc010nnb.3) ENST00000276141(uc010nnc.3)
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    Additional mRNA sequence: 

    AF302493.1 AK098473.1 AK292588.1 AK313086.1 BC014913.1 BX537410.1 

    14 DOTS entries:

    DT.75164170  DT.97838291  DT.121288743  DT.100024039  DT.100781864  DT.100710360  DT.313497  DT.95254560 
    DT.97770414  DT.121288752  DT.91746458  DT.121288742  DT.91650038  DT.95201869 

    24/78 AceView cDNA sequences (see all 78):

    NM_080737 AA573470 BU159587 AA775571 AI362789 BC014913 BU675401 AI367961 
    BQ435318 BX471789 AF150118 BX382206 AA370481 BX471979 AW511007 BM905943 
    BG398971 BX537410 AL832596 BU154605 BM467790 AI204375 BE890004 AI278198 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                            -               
    SP2:              -     -     -                                                                                                                 -               
    SP3:              -     -     -     -                                                                                                           -               
    SP4:              -           -                                                                                                                                 
    SP5:                          -     -                       -     -                                                                                             

    ExUns: 20b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SYTL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYTL4 expression in normal human tissues (normalized intensities)      SYTL4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTGTGCT
    SYTL4 Expression
    About this image


    SYTL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor W10
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See SYTL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYTL4

    SOURCE GeneReport for Unigene cluster: Hs.592224
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYTL4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl41 , 5 synaptotagmin-like 41, 5 89.52(n)1
    90.61(a)1
      X (55.47 cM)5
    273591  NM_013757.11  NP_038785.11 
     1339363855 
    chicken
    (Gallus gallus)
    Aves SYTL41 synaptotagmin-like 4 71.79(n)
    70.89(a)
      422260  XM_003641076.1  XP_003641124.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.187502 Transcribed sequence with moderate similarity to protein more 75.36(n)    AL970091.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1584111 zgc:158411 57(n)
    51.3(a)
      553322  NM_001080988.1  NP_001074457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73433 synaptic vesicle endocytosis protein
    transporter
    43(a)   88D4   --


    ENSEMBL Gene Tree for SYTL4 (if available)
    TreeFam Gene Tree for SYTL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYTL4 gene
    SYTL52  SYTL12  SYTL32  SYTL22  
    14 SIMAP similar genes for SYTL4 using alignment to 2 protein entries:     SYTL4_HUMAN (see all proteins):
    CHR11SYT    SYT4    SYTL2    SYTL5    PRKCG    SYT15
    SYT1    SYT11    SYT2    SYTL1    RPH3A    SYTL3
    MYRIP    MLPH

    SYTL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/818 SNPs in SYTL4 are shown (see all 818)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449772351,2
    --99895292(+) AAAAGA/CAAAAG 3 -- int1 ds50010--------
    rs1389100571,2
    --99895383(+) CATCTA/CTCTCC 3 -- int1 ds50010--------
    rs1892809401,2
    --99895480(+) TCTCAA/GTGTTC 3 -- int1 ds50010--------
    rs1820209541,2
    --99895705(+) ACACAA/GACGTT 3 -- int1 ds50010--------
    rs1406122941,2
    --99895708(+) CAAACA/GTTTGA 3 -- spd1 ds50010--------
    rs87801,2
    C,F,A,H--99895753(-) ACCCCC/GCTGAC 3 -- ut3114Minor allele frequency- G:0.36MN NS EA NA WA 1218
    rs1857698321,2
    --99895858(+) CCATTC/TGGTTC 3 -- ut310--------
    rs1906320641,2
    --99895859(+) CATTCA/GGTTCA 3 -- ut310--------
    rs1834974691,2
    --99896026(+) TTGATC/GAATGA 3 -- ut310--------
    rs1863948281,2
    C--99896306(+) TAACAC/TACCCC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SYTL4 (99929488 - 99987135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYTL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510850CNV Loss20534489


    Human Gene Mutation Database (HGMD): SYTL4

    Locus Specific Mutation Databases (LSDB): SYTL4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYTL4
    DNA2.0 Custom Variant and Variant Library Synthesis for SYTL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300723    OMIM disorders: --

    2 diseases for SYTL4:    About MalaCards
    hyperglycemia    pancreatitis


    SYTL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYTL4

    Export disorders for SYTL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYTL4 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with SYTL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. (PubMed id 16831872)1, 7, 9 Plaisance V....Regazzi R. (2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. (PubMed id 15028737)7, 9 Torii S....Izumi T. (2004)
    7. Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. (PubMed id 10497219)1, 9 Wang J....Izumi T. (1999)
    8. Rab27a and Rab27b control different steps of the exos ome secretion pathway. (PubMed id 19966785)1, 9 Ostrowski M....Thery C. (2010)
    9. Involvement of Rab27b in the regulated secretion of pituitary hormones. (PubMed id 11956164)1, 9 Zhao S....Izumi T. (2002)
    10. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PubMed id 12590134)1, 9 Fukuda M. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 94121 HGNC: 15588 AceView: SYTL4 Ensembl:ENSG00000102362 euGenes: HUgn94121
    ECgene: SYTL4 H-InvDB: SYTL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYTL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYTL4 gene:
    Search GeneIP for patents involving SYTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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