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SYTL4 Gene

protein-coding   GIFtS: 57
GCID: GC0XM099929

Synaptotagmin-Like 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin-Like 41 2     Synaptotagmin-Like Protein 42
exophilin-21 2     Exophilin-23
granuphilin-a1 2     Granuphilin3
SLP42     

External Ids:    HGNC: 155881   Entrez Gene: 941212   Ensembl: ENSG000001023627   OMIM: 3007235   UniProtKB: Q96C243   

Export aliases for SYTL4 gene to outside databases

Previous GC identifers: GC0XM095211 GC0XM096890 GC0XM097965 GC0XM098701 GC0XM099735 GC0XM089729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYTL4 Gene:
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by
an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab
GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in
inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode
the same protein. (provided by RefSeq, Mar 2010)

GeneCards Summary for SYTL4 Gene:
SYTL4 (synaptotagmin-like 4) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rab GTPase binding. An important paralog of this gene is SYTL5.

UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24
Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.
Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By
similarity)

Gene Wiki entry for SYTL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYTL4 gene promoter:
         FOXL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL4 promoter sequence
   Search Chromatin IP Primers for SYTL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33

SYTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM099929:  view genomic region     (about GC identifiers)

Start:
99,929,488 bp from pter      End:
99,987,135 bp from pter
Size:
57,648 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 4  
Size: 671 amino acids; 76024 Da
Subunit: Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant
active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity)
2 PDB 3D structures from and Proteopedia for SYTL4:
2CSZ (3D)        3FDW (3D)    
Secondary accessions: Q5H9J3 Q5JPG8 Q8N9P4 Q9H4R0 Q9H4R1
Alternative splicing: 2 isoforms:  Q96C24-1   Q96C24-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL4: NX_Q96C24

Explore proteomics data for SYTL4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYTL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123368.1  NP_001167539.1  NP_542775.2  

    ENSEMBL proteins: 
     ENSP00000362080   ENSP00000263033   ENSP00000362072   ENSP00000390252   ENSP00000403556  
     ENSP00000276141  

    SYTL4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SYTL4

     
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    antibodies-online proteins for SYTL4 (3 products) 

     
    antibodies-online peptides for SYTL4

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    antibodies-online antibodies for SYTL4 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001841 Znf_RING
     IPR001565 Synaptotagmin
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q96C24

    ProtoNet protein and cluster: Q96C24

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: SYTL4_HUMAN, Q96C24
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RabBD (Rab-binding) domain


    Find genes that share domains with SYTL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL4_HUMAN, Q96C24
    Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary.
    Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ISS--
    GO:0008270zinc ion binding IEA--
    GO:0017137Rab GTPase binding IEA--
         
    Find genes that share ontologies with SYTL4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SYTL4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Low eccentricity cells 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sytl4):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with SYTL4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sytl4tm1Tiz for SYTL4

       genOway: Develop your customized and physiologically relevant rodent model for SYTL4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SYTL4 (see all 24):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-539 hsa-miR-106a hsa-miR-885-5p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYTL4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYTL4
    Predesigned siRNA for gene silencing in human, mouse, rat SYTL4

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL4
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    Addgene plasmids for SYTL4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTL4_HUMAN, Q96C24: Membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane
    protein (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (By
    similarity). Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with
    insulin-containing vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytoskeleton4
    cytosol4
    nucleus4
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IDA19966785
    GO:0005813centrosome IDA--

    Find genes that share ontologies with SYTL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYTL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL4
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYTL4
    Interactions:

        Search GeneGlobe Interaction Network for SYTL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SYTL4 (Q96C243 ENSP000002630334) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STXBP1P617643, ENSP000003623994I2D: score=5 STRING: ENSP00000362399
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    RAB27BO001943, ENSP000002620944I2D: score=2 STRING: ENSP00000262094
    USP20Q9Y2K63, ENSP000003138114I2D: score=2 STRING: ENSP00000313811
    RAB27AP511593, ENSP000003377614I2D: score=5 STRING: ENSP00000337761
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--
    GO:0045921positive regulation of exocytosis IMP19966785
    GO:0046676negative regulation of insulin secretion IEA--
    GO:0050714positive regulation of protein secretion IMP19966785

    Find genes that share ontologies with SYTL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for SYTL4

    2 DrugBank Compounds for SYTL4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Insulin, porcine-- 9004-14-2target--16831872 16216924 15028737 17016423 17139284
    Insulin Regular -- 11061-68-0target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for SYTL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 17.5 2 18177263 (1), 18397364 (1)



    Find genes that share compounds with SYTL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYTL4 gene (3 alternative transcripts): 
    NM_001129896.2  NM_001174068.1  NM_080737.2  

    Unigene Cluster for SYTL4:

    Synaptotagmin-like 4
    Hs.592224  [show with all ESTs]
    Unigene Representative Sequence: NM_080737
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372989(uc004egd.4 uc004ege.4 uc004egf.4) ENST00000491602(uc004egc.3)
    ENST00000263033 ENST00000372981(uc004egg.4) ENST00000491326 ENST00000455616
    ENST00000454200(uc010nnb.3) ENST00000276141(uc010nnc.3)
    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-539 hsa-miR-106a hsa-miR-885-5p hsa-miR-302e hsa-miR-520a-3p
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    Addgene plasmids for SYTL4 
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    Additional mRNA sequence: 

    AF302493.1 AK098473.1 AK292588.1 AK313086.1 BC014913.1 BX537410.1 

    14 DOTS entries:

    DT.75164170  DT.97838291  DT.121288743  DT.100024039  DT.100781864  DT.100710360  DT.313497  DT.95254560 
    DT.97770414  DT.121288752  DT.91746458  DT.121288742  DT.91650038  DT.95201869 

    Selected AceView cDNA sequences (see all 78):

    BU675401 BC014913 BU159587 AI362789 AI367961 BQ435318 AA573470 NM_080737 
    AA775571 BU154605 BX496487 BX382206 AK098279 BM905943 AA853282 AF150118 
    BX371933 AA782876 AW511007 BM462495 AL708502 BG398971 AA195710 AI204375 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYTL4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                            -               
    SP2:              -     -     -                                                                                                                 -               
    SP3:              -     -     -     -                                                                                                           -               
    SP4:              -           -                                                                                                                                 
    SP5:                          -     -                       -     -                                                                                             

    ExUns: 20b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SYTL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYTL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTGTGCT
    SYTL4 Expression
    About this image


    SYTL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Adrenal Gland (Endocrine System)
    SYTL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYTL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592224
        Custom PCR Arrays for SYTL4
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYTL4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl41 , 5 synaptotagmin-like 41, 5 89.52(n)1
    90.61(a)1
      X (55.47 cM)5
    273591  NM_013757.11  NP_038785.11 
     1339363855 
    chicken
    (Gallus gallus)
    Aves SYTL41 synaptotagmin-like 4 71.74(n)
    70.89(a)
      422260  XM_004940701.1  XP_004940758.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.187502 Transcribed sequence with moderate similarity to protein more 75.36(n)    AL970091.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sytl41 synaptotagmin-like 4 56.95(n)
    51.3(a)
      553322  NM_001080988.1  NP_001074457.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73433
    btsz1
    synaptic vesicle endocytosis protein
    transporter3
    bitesize1
    43(a)3
    49.74(n)1
    45.16(a)1
      88D43
    33461671  NM_001275653.11  NP_001262582.11 


    ENSEMBL Gene Tree for SYTL4 (if available)
    TreeFam Gene Tree for SYTL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYTL4 gene
    SYTL52  DOC2B2  SYTL12  DOC2A2  SYTL32  RPH3A2  SYTL22  
    14 SIMAP similar genes for SYTL4 using alignment to 2 protein entries:     SYTL4_HUMAN (see all proteins):
    CHR11SYT    SYT4    SYTL2    SYTL5    PRKCG    SYT15
    SYT1    SYT11    SYT2    SYTL1    RPH3A    SYTL3
    MYRIP    MLPH

    Find genes that share paralogs with SYTL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYTL4 (see all 818)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449772351,2
    --99895292(+) AAAAGA/CAAAAG 3 -- int1 ds50010--------
    rs1389100571,2
    --99895383(+) CATCTA/CTCTCC 3 -- int1 ds50010--------
    rs1892809401,2
    --99895480(+) TCTCAA/GTGTTC 3 -- int1 ds50010--------
    rs1820209541,2
    --99895705(+) ACACAA/GACGTT 3 -- int1 ds50010--------
    rs1406122941,2
    --99895708(+) CAAACA/GTTTGA 3 -- spd1 ds50010--------
    rs87801,2
    C,F,A,H--99895753(-) ACCCCC/GCTGAC 3 -- ut3114Minor allele frequency- G:0.36MN NS EA NA WA 1218
    rs1857698321,2
    --99895858(+) CCATTC/TGGTTC 3 -- ut310--------
    rs1906320641,2
    --99895859(+) CATTCA/GGTTCA 3 -- ut310--------
    rs1834974691,2
    --99896026(+) TTGATC/GAATGA 3 -- ut310--------
    rs1863948281,2
    C--99896306(+) TAACAC/TACCCC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SYTL4 (99929488 - 99987135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYTL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510850CNV Loss20534489

    Human Gene Mutation Database (HGMD): SYTL4
    Locus Specific Mutation Databases (LSDB): SYTL4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYTL4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300723    OMIM disorders: --


    Find genes that share disorders with SYTL4           About GenesLikeMe

    Genetic Association Database (GAD): SYTL4

    Export disorders for SYTL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYTL4 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SYTL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. (PubMed id 16831872)1, 7, 9 Plaisance V....Regazzi R. (J. Biol. Chem. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. (PubMed id 15028737)7, 9 Torii S....Izumi T. (J. Biol. Chem. 2004)
    7. Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. (PubMed id 10497219)1, 9 Wang J....Izumi T. (J. Biol. Chem. 1999)
    8. Rab27a and Rab27b control different steps of the exosome secretion pathway. (PubMed id 19966785)1, 9 Ostrowski M....Thery C. (Nat. Cell Biol. 2010)
    9. Involvement of Rab27b in the regulated secretion of pituitary hormones. (PubMed id 11956164)1, 9 Zhao S....Izumi T. (Endocrinology 2002)
    10. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PubMed id 12590134)1, 9 Fukuda M. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94121 HGNC: 15588 AceView: SYTL4 Ensembl:ENSG00000102362 euGenes: HUgn94121
    ECgene: SYTL4 H-InvDB: SYTL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYTL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYTL4 gene:
    Search GeneIP for patents involving SYTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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