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Aliases for SYTL3 Gene

Aliases for SYTL3 Gene

  • Synaptotagmin Like 3 2 3 5
  • Exophilin-6 3 4
  • SLP3 3 4

External Ids for SYTL3 Gene

Previous GeneCards Identifiers for SYTL3 Gene

  • GC06P158521
  • GC06P158944
  • GC06P158980
  • GC06P159041
  • GC06P158991
  • GC06P159071
  • GC06P156541

Summaries for SYTL3 Gene

Entrez Gene Summary for SYTL3 Gene

  • The protein encoded by this gene belongs to a family of peripheral membrane proteins that play a role in vesicular trafficking. This protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for SYTL3 Gene

SYTL3 (Synaptotagmin Like 3) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for SYTL3 Gene

  • May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL3 Gene

Genomics for SYTL3 Gene

Regulatory Elements for SYTL3 Gene

Genomic Location for SYTL3 Gene

Chromosome:
6
Start:
158,644,899 bp from pter
End:
158,764,876 bp from pter
Size:
119,978 bases
Orientation:
Plus strand

Genomic View for SYTL3 Gene

Genes around SYTL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL3 Gene

Proteins for SYTL3 Gene

  • Protein details for SYTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VX76-SYTL3_HUMAN
    Recommended name:
    Synaptotagmin-like protein 3
    Protein Accession:
    Q4VX76
    Secondary Accessions:
    • Q496J4
    • Q496J6
    • Q5U3B9

    Protein attributes for SYTL3 Gene

    Size:
    610 amino acids
    Molecular mass:
    68560 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity).

    Alternative splice isoforms for SYTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL3 Gene

Proteomics data for SYTL3 Gene at MOPED

Post-translational modifications for SYTL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYTL3 Gene

Domains & Families for SYTL3 Gene

Gene Families for SYTL3 Gene

Protein Domains for SYTL3 Gene

Suggested Antigen Peptide Sequences for SYTL3 Gene

Graphical View of Domain Structure for InterPro Entry

Q4VX76

UniProtKB/Swiss-Prot:

SYTL3_HUMAN :
  • Contains 2 C2 domains.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL3: view

Function for SYTL3 Gene

Molecular function for SYTL3 Gene

UniProtKB/Swiss-Prot Function:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005543 phospholipid binding IEA --
GO:0005544 calcium-dependent phospholipid binding IEA,IBA --
GO:0042043 neurexin family protein binding IEA --
genes like me logo Genes that share ontologies with SYTL3: view

Phenotypes for SYTL3 Gene

genes like me logo Genes that share phenotypes with SYTL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYTL3 Gene

Localization for SYTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL3 Gene

Endomembrane system; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL3 Gene COMPARTMENTS Subcellular localization image for SYTL3 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019897 extrinsic component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SYTL3: view

Pathways & Interactions for SYTL3 Gene

genes like me logo Genes that share pathways with SYTL3: view

Pathways by source for SYTL3 Gene

Gene Ontology (GO) - Biological Process for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYTL3: view

No data available for SIGNOR curated interactions for SYTL3 Gene

Drugs & Compounds for SYTL3 Gene

(2) Drugs for SYTL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with SYTL3: view

Transcripts for SYTL3 Gene

Unigene Clusters for SYTL3 Gene

Synaptotagmin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - -
SP9: -
SP10: - - -
SP11: - -
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SYTL3 Gene

GeneLoc Exon Structure for
SYTL3
ECgene alternative splicing isoforms for
SYTL3

Expression for SYTL3 Gene

mRNA expression in normal human tissues for SYTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL3 Gene

This gene is overexpressed in Whole Blood (x16.1).

Protein differential expression in normal tissues from HIPED for SYTL3 Gene

This gene is overexpressed in Urine (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYTL3 Gene



SOURCE GeneReport for Unigene cluster for SYTL3 Gene Hs.436977

genes like me logo Genes that share expression patterns with SYTL3: view

Protein tissue co-expression partners for SYTL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYTL3 Gene

Orthologs for SYTL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYTL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL3 35
  • 98.69 (n)
  • 98.52 (a)
SYTL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYTL3 36
  • 77 (a)
OneToOne
SYTL3 35
  • 82.38 (n)
  • 78 (a)
dog
(Canis familiaris)
Mammalia SYTL3 35
  • 84.92 (n)
  • 80.82 (a)
SYTL3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sytl3 16
Sytl3 36
  • 80 (a)
OneToOne
Sytl3 35
  • 82.32 (n)
  • 80.07 (a)
oppossum
(Monodelphis domestica)
Mammalia SYTL3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYTL3 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sytl3 35
  • 80.87 (n)
  • 79.44 (a)
chicken
(Gallus gallus)
Aves SYTL3 35
  • 64.46 (n)
  • 60.1 (a)
SYTL3 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYTL3 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl3 35
  • 61.09 (n)
  • 58.84 (a)
zebrafish
(Danio rerio)
Actinopterygii sytl3 36
  • 35 (a)
OneToOne
Species with no ortholog for SYTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL3 Gene

ENSEMBL:
Gene Tree for SYTL3 (if available)
TreeFam:
Gene Tree for SYTL3 (if available)

Paralogs for SYTL3 Gene

Paralogs for SYTL3 Gene

(7) SIMAP similar genes for SYTL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYTL3: view

Variants for SYTL3 Gene

Sequence variations from dbSNP and Humsavar for SYTL3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs901363 - 158,757,313(-) CAGAG(A/G)AATGA reference, missense
rs2291388 - 158,763,404(-) GGTTA(C/T)GCCAC reference, missense
VAR_037139 -
rs317791 -- 158,677,481(-) gccat(C/G)atgtt intron-variant
rs317792 -- 158,655,734(-) CACGG(A/C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL3 Gene

Variant ID Type Subtype PubMed ID
nsv5562 CNV Insertion 18451855
nsv523641 CNV Gain 19592680
esv2733001 CNV Deletion 23290073
esv2587253 CNV Insertion 19546169
esv2733002 CNV Deletion 23290073
nsv528709 CNV Loss 19592680
nsv528373 CNV Loss 19592680
esv2733003 CNV Deletion 23290073
esv2134507 CNV Deletion 18987734
nsv349192 CNV Loss 16902084
esv24318 CNV Loss 19812545
dgv1075e201 CNV Deletion 23290073
esv2678909 CNV Deletion 23128226
dgv1076e201 CNV Deletion 23290073
esv2733013 CNV Deletion 23290073
nsv823893 CNV Loss 20364138
nsv823894 CNV Loss 20364138
esv2663267 CNV Deletion 23128226
esv2733014 CNV Deletion 23290073
esv268294 CNV Insertion 20981092
esv274467 CNV Insertion 20981092

Variation tolerance for SYTL3 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.33; 96.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL3 Gene

HapMap Linkage Disequilibrium report
SYTL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL3 Gene

Disorders for SYTL3 Gene

Relevant External Links for SYTL3

Genetic Association Database (GAD)
SYTL3
Human Genome Epidemiology (HuGE) Navigator
SYTL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL3

No disorders were found for SYTL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL3 Gene

Publications for SYTL3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. (PMID: 11773082) Kuroda T.S. … Mikoshiba K. (J. Biol. Chem. 2002) 2 3
  3. The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I. (PMID: 12049610) Fukuda M. (Biochem. J. 2002) 3 23
  4. Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate. (PMID: 25940347) Gerber P.P. … Ostrowski M. (J. Cell Biol. 2015) 3
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for SYTL3 Gene

Sources for SYTL3 Gene

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