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SYTL3 Gene

protein-coding   GIFtS: 52
GCID: GC06P159071

Synaptotagmin-Like 3

  Search for SYTL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin-Like 31 2
SLP32 3
exophilin-62
Synaptotagmin-Like Protein 32
Exophilin-63

External Ids:    HGNC: 155871   Entrez Gene: 941202   Ensembl: ENSG000001646747   UniProtKB: Q4VX763   

Export aliases for SYTL3 gene to outside databases

Previous GC identifers: GC06P158521 GC06P158944 GC06P158980 GC06P159041 GC06P158991 GC06P156541


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYTL3 Gene:
The protein encoded by this gene belongs to the family of synaptotagmin-like proteins (SLPs). SLPs are peripheral
membrane proteins that interact with RAB27A protein, and play a role in vesicular trafficking. Unlike, SLPs 1 and
2, this protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for SYTL3 Gene:
SYTL3 (synaptotagmin-like 3) is a protein-coding gene. GO annotations related to this gene include neurexin family protein binding and Rab GTPase binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: SYTL3_HUMAN, Q4VX76
Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the
presence of calcium ions (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYTL3 gene promoter:
         Elk-1   Nkx2-5   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   LCR-F1   POU3F2   MEF-2A   FAC1   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL3 promoter sequence
   Search Chromatin IP Primers for SYTL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYTL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

SYTL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P159071:  view genomic region     (about GC identifiers)

Start:
159,071,046 bp from pter      End:
159,185,908 bp from pter
Size:
114,863 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYTL3_HUMAN, Q4VX76 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 3  
Size: 610 amino acids; 68560 Da
Subunit: Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By
similarity)
Secondary accessions: Q496J4 Q496J6 Q5U3B9
Alternative splicing: 2 isoforms:  Q4VX76-1   Q4VX76-2   

Explore the universe of human proteins at neXtProt for SYTL3: NX_Q4VX76

Explore proteomics data for SYTL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYTL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001009991.2  NP_001229313.1  NP_001229323.1  NP_001229324.1  

    ENSEMBL proteins: 
     ENSP00000297239   ENSP00000353631   ENSP00000356048  

    SYTL3 Human Recombinant Protein Products:

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    SYTL3 Antibody Products:

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    SYTL3 Assay Products:

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    Cloud-Clone Corp. CLIAs for SYTL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028704 SYTL3
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR000008 C2_dom
     IPR010911 Znf_FYVE-typ

    Graphical View of Domain Structure for InterPro Entry Q4VX76

    ProtoNet protein and cluster: Q4VX76

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYTL3_HUMAN, Q4VX76
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 RabBD (Rab-binding) domain


    SYTL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL3_HUMAN, Q4VX76
    Function: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the
    presence of calcium ions (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ----
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0017137Rab GTPase binding IEA--
    GO:0042043neurexin family protein binding IEA--
         
    SYTL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYTL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYTL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYTL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYTL3

    miRNA
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    Block miRNA regulation of human, mouse, rat SYTL3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SYTL3
    SwitchGear 3'UTR luciferase reporter plasmidSYTL3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYTL3
    Predesigned siRNA for gene silencing in human, mouse, rat SYTL3

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    GenScript: all cDNA clones in your preferred vector: SYTL3 (NM_001009991)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTL3_HUMAN, Q4VX76: Endomembrane system; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0012505endomembrane system IEA--
    GO:0016020membrane ----
    GO:0019897extrinsic component of plasma membrane IEA--

    SYTL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYTL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL3
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYTL3
    Interactions:

        Search GeneGlobe Interaction Network for SYTL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SYTL3 (Q4VX762, 3 ENSP000003536314) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB27AP511593, ENSP000003377614I2D: score=4 STRING: ENSP00000337761
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    RAB10P610263, ENSP000002647104I2D: score=1 STRING: ENSP00000264710
    RAB5CENSP000003456894STRING: ENSP00000345689
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IEA--

    SYTL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYTL3

    2 HMDB Compounds for SYTL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYTL3 gene (4 alternative transcripts): 
    NM_001009991.3  NM_001242384.1  NM_001242394.1  NM_001242395.1  

    Unigene Cluster for SYTL3:

    Synaptotagmin-like 3
    Hs.436977  [show with all ESTs]
    Unigene Representative Sequence: AL833750
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469735 ENST00000297239(uc003qrp.3 uc003qrr.3) ENST00000360448(uc003qro.3 uc003qrs.3 uc011efq.2)
    ENST00000367081
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSYTL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYTL3
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    GenScript: all cDNA clones in your preferred vector: SYTL3 (NM_001009991)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SYTL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYTL3
      QuantiTect SYBR Green Assays in human, mouse, rat SYTL3
      QuantiFast Probe-based Assays in human, mouse, rat SYTL3

    Additional mRNA sequence: 

    AK055750.1 AK298712.1 AK304191.1 AL833750.1 BC085612.1 BC100830.1 BC100831.1 

    9 DOTS entries:

    DT.107033  DT.101982452  DT.121311807  DT.100735875  DT.70103103  DT.100742074  DT.121311820  DT.40290927 
    DT.107032 

    Selected AceView cDNA sequences (see all 47):

    BU155667 CF785849 AK131092 BG059457 AW197467 CR613848 AI373549 BE466417 
    AL538173 AW578406 BU620189 AK092729 CA394344 BF115631 AA310278 AK055750 
    AI990716 BG214448 AX747692 AW291923 AL833750 BG169355 CA450395 BU633217 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYTL3 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                                        -     -     -     -           -     -                 -                                             
    SP2:                                            -           -     -     -     -           -     -                 -                       -     -               
    SP3:                                                                                            -                 -                                             
    SP4:                                                        -     -     -     -           -     -                 -                       -     -               
    SP5:              -                                         -     -     -     -     -     -     -                                                               

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SYTL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYTL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTAACCGC
    SYTL3 Expression
    About this image


    SYTL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Thymus (Hematopoietic System)
    SYTL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYTL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436977
        Custom PCR Arrays for SYTL3
    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYTL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYTL3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl31 , 5 synaptotagmin-like 31, 5 82.32(n)1
    80.07(a)1
      17 (4.33 cM)5
    836721  NM_031395.21  NP_113572.11 
     66734585 
    chicken
    (Gallus gallus)
    Aves SYTL31 synaptotagmin-like 3 64.46(n)
    60.1(a)
      100858462  XM_003640961.2  XP_003641009.2 
    lizard
    (Anolis carolinensis)
    Reptilia SYTL36
    synaptotagmin-like 3
    55(a)
    1 ↔ 1
    1(212733333-212764606)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sytl31 synaptotagmin-like 3 61.09(n)
    58.84(a)
      100379855  XM_002937212.2  XP_002937258.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sytl36
    synaptotagmin-like 3
    35(a)
    1 ↔ 1
    20(13448318-13480494) ENSDARG00000043468


    ENSEMBL Gene Tree for SYTL3 (if available)
    TreeFam Gene Tree for SYTL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYTL3 gene
    SYTL42  SYTL52  DOC2B2  SYTL12  DOC2A2  RPH3A2  SYTL22  
    7 SIMAP similar genes for SYTL3 using alignment to 3 protein entries:     SYTL3_HUMAN (see all proteins):
    FLJ00307    CHR11SYT    SYTL2    SYTL1    SYT15    SYTL4
    RPH3A

    SYTL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYTL3 (see all 2892)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864516901,2
    --159069311(+) TGGCTC/TACACC 4 -- us2k10--------
    rs1432894381,2
    C--159069373(+) GAGTTC/GGAGAC 4 -- us2k10--------
    rs1893021911,2
    --159069437(+) AGGCAG/TGGTGG 4 -- us2k10--------
    rs1808318611,2
    --159069516(+) ATTGCA/GGTGAG 4 -- us2k10--------
    rs1388353671,2
    --159069613(+) TCACGA/CCTGTA 4 -- us2k10--------
    rs69108001,2
    C,A--159069645(+) GAGGCA/GGGCGG 4 -- us2k11Minor allele frequency- G:0.00NA 2
    rs69111611,2
    C,F,A--159069867(+) cgctcA/Ggtctc 4 -- us2k13Minor allele frequency- G:0.33NA 6
    rs2016194831,2
    --159069883(+) AAAAA-/TAAAAA 4 -- us2k10--------
    rs69346391,2
    C,A--159069889(+) AAAAAT/AAATAA 4 -- us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs1138380071,2
    C--159069892(+) AAAAAA/TAATAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYTL3 (159071046 - 159185908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYTL3 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663267CNV Deletion23128226
    esv2733001CNV Deletion23290073
    dgv1075e201CNV Deletion23290073
    esv2733013CNV Deletion23290073
    esv2733003CNV Deletion23290073
    dgv1076e201CNV Deletion23290073
    esv2733002CNV Deletion23290073
    esv2134507CNV Deletion18987734
    esv2733014CNV Deletion23290073
    esv2678909CNV Deletion23128226

    Human Gene Mutation Database (HGMD): SYTL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYTL3
    DNA2.0 Custom Variant and Variant Library Synthesis for SYTL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    SYTL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYTL3
    Human Genome Epidemiology (HuGE) Navigator: SYTL3 (3 documents)

    Export disorders for SYTL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYTL3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SYTL3)
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    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. (PubMed id 11773082)1, 3 Kuroda T.S.... Mikoshiba K. (J. Biol. Chem. 2002)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    10. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. (PubMed id 12590134)1 Fukuda M. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94120 HGNC: 15587 AceView: SYTL3 Ensembl:ENSG00000164674 euGenes: HUgn94120
    ECgene: SYTL3 H-InvDB: SYTL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYTL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYTL3 gene:
    Search GeneIP for patents involving SYTL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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