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Aliases for SYTL3 Gene

Aliases for SYTL3 Gene

  • Synaptotagmin-Like 3 2 3
  • Exophilin-6 3 4
  • SLP3 3 4
  • Synaptotagmin-Like Protein 3 3

External Ids for SYTL3 Gene

Previous GeneCards Identifiers for SYTL3 Gene

  • GC06P158521
  • GC06P158944
  • GC06P158980
  • GC06P159041
  • GC06P158991
  • GC06P159071
  • GC06P156541

Summaries for SYTL3 Gene

Entrez Gene Summary for SYTL3 Gene

  • The protein encoded by this gene belongs to the family of synaptotagmin-like proteins (SLPs). SLPs are peripheral membrane proteins that interact with RAB27A protein, and play a role in vesicular trafficking. Unlike, SLPs 1 and 2, this protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for SYTL3 Gene

SYTL3 (Synaptotagmin-Like 3) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include Rab GTPase binding and neurexin family protein binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for SYTL3 Gene

  • May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL3 Gene

Genomics for SYTL3 Gene

Regulatory Elements for SYTL3 Gene

Genomic Location for SYTL3 Gene

158,644,899 bp from pter
158,764,876 bp from pter
119,978 bases
Plus strand

Genomic View for SYTL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL3 Gene

Proteins for SYTL3 Gene

  • Protein details for SYTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptotagmin-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q496J4
    • Q496J6
    • Q5U3B9

    Protein attributes for SYTL3 Gene

    610 amino acids
    Molecular mass:
    68560 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity).

    Alternative splice isoforms for SYTL3 Gene


neXtProt entry for SYTL3 Gene

Proteomics data for SYTL3 Gene at MOPED

Post-translational modifications for SYTL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYTL3 Gene

Antibody Products

No data available for DME Specific Peptides for SYTL3 Gene

Domains for SYTL3 Gene

Gene Families for SYTL3 Gene

Protein Domains for SYTL3 Gene

Suggested Antigen Peptide Sequences for SYTL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL3: view

Function for SYTL3 Gene

Molecular function for SYTL3 Gene

UniProtKB/Swiss-Prot Function:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005543 phospholipid binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with SYTL3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYTL3 Gene

Localization for SYTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL3 Gene

Endomembrane system; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for SYTL3 Gene COMPARTMENTS Subcellular localization image for SYTL3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane --
GO:0019897 extrinsic component of plasma membrane IEA --
GO:0070382 exocytic vesicle IBA --
genes like me logo Genes that share ontologies with SYTL3: view

Pathways for SYTL3 Gene

genes like me logo Genes that share pathways with SYTL3: view

Pathways by source for SYTL3 Gene

Gene Ontology (GO) - Biological Process for SYTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
genes like me logo Genes that share ontologies with SYTL3: view

Drugs for SYTL3 Gene

(2) HMDB Compounds for SYTL3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with SYTL3: view

Transcripts for SYTL3 Gene

Unigene Clusters for SYTL3 Gene

Synaptotagmin-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP8: - - - - - -
SP9: -
SP10: - - -
SP11: - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
SP7: -

Relevant External Links for SYTL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYTL3 Gene

mRNA expression in normal human tissues for SYTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL3 Gene

This gene is overexpressed in Whole Blood (16.1).

Protein differential expression in normal tissues for SYTL3 Gene

This gene is overexpressed in Urine (65.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYTL3 Gene

SOURCE GeneReport for Unigene cluster for SYTL3 Gene Hs.436977

genes like me logo Genes that share expressions with SYTL3: view

Expression partners for SYTL3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYTL3 Gene

Orthologs for SYTL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYTL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYTL3 35
  • 82.38 (n)
  • 78 (a)
SYTL3 36
  • 77 (a)
(Canis familiaris)
Mammalia SYTL3 35
  • 84.92 (n)
  • 80.82 (a)
SYTL3 36
  • 81 (a)
(Mus musculus)
Mammalia Sytl3 35
  • 82.32 (n)
  • 80.07 (a)
Sytl3 16
Sytl3 36
  • 80 (a)
(Pan troglodytes)
Mammalia SYTL3 35
  • 98.69 (n)
  • 98.52 (a)
SYTL3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sytl3 35
  • 80.87 (n)
  • 79.44 (a)
(Monodelphis domestica)
Mammalia SYTL3 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SYTL3 36
  • 58 (a)
(Gallus gallus)
Aves SYTL3 35
  • 64.46 (n)
  • 60.1 (a)
SYTL3 36
  • 58 (a)
(Anolis carolinensis)
Reptilia SYTL3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl3 35
  • 61.09 (n)
  • 58.84 (a)
(Danio rerio)
Actinopterygii sytl3 36
  • 35 (a)
Species with no ortholog for SYTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL3 Gene

Gene Tree for SYTL3 (if available)
Gene Tree for SYTL3 (if available)

Paralogs for SYTL3 Gene

Paralogs for SYTL3 Gene

(7) SIMAP similar genes for SYTL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYTL3: view

Variants for SYTL3 Gene

Sequence variations from dbSNP and Humsavar for SYTL3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs317789 -- 158,680,261(-) TGGAG(C/T)ACTTG intron-variant
rs317790 -- 158,678,035(-) gtgca(C/T)gccag intron-variant
rs317791 -- 158,677,481(-) gccat(C/G)atgtt intron-variant
rs317792 -- 158,655,734(-) CACGG(A/C)GGTGC intron-variant
rs317793 -- 158,653,970(-) AGAGA(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL3 Gene

Variant ID Type Subtype PubMed ID
nsv5562 CNV Insertion 18451855
nsv523641 CNV Gain 19592680
esv2733001 CNV Deletion 23290073
esv2587253 CNV Insertion 19546169
esv2733002 CNV Deletion 23290073
nsv528709 CNV Loss 19592680
nsv528373 CNV Loss 19592680
esv2733003 CNV Deletion 23290073
esv2134507 CNV Deletion 18987734
nsv349192 CNV Loss 16902084
esv24318 CNV Loss 19812545
dgv1075e201 CNV Deletion 23290073
esv2678909 CNV Deletion 23128226
dgv1076e201 CNV Deletion 23290073
esv2733013 CNV Deletion 23290073
nsv823893 CNV Loss 20364138
nsv823894 CNV Loss 20364138
esv2663267 CNV Deletion 23128226
esv2733014 CNV Deletion 23290073
esv268294 CNV Insertion 20981092
esv274467 CNV Insertion 20981092

Relevant External Links for SYTL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL3 Gene

Disorders for SYTL3 Gene

Relevant External Links for SYTL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SYTL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SYTL3 Gene

Publications for SYTL3 Gene

  1. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. (PMID: 11773082) Kuroda T.S. … Mikoshiba K. (J. Biol. Chem. 2002) 2 3
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SYTL3 Gene

Sources for SYTL3 Gene

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