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Aliases for SYTL2 Gene

Aliases for SYTL2 Gene

  • Synaptotagmin Like 2 2 3 5
  • Breast Cancer-Associated Antigen SGA-72M 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 151 2 3
  • Chromosome 11 Synaptotagmin 2 3
  • Exophilin-4 3 4
  • SGA72M 3 4
  • SLP2A 3 4
  • SLP2 3 4
  • Synaptotagmin-Like Protein 2 3
  • CHR11SYT 3
  • PPP1R151 3
  • KIAA1597 4
  • EXO4 3

External Ids for SYTL2 Gene

Previous GeneCards Identifiers for SYTL2 Gene

  • GC11M087732
  • GC11M086944
  • GC11M085628
  • GC11M085131
  • GC11M085082
  • GC11M085405
  • GC11M081702

Summaries for SYTL2 Gene

Entrez Gene Summary for SYTL2 Gene

  • The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

GeneCards Summary for SYTL2 Gene

SYTL2 (Synaptotagmin Like 2) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and Rab GTPase binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for SYTL2 Gene

  • Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Gene Wiki entry for SYTL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL2 Gene

Genomics for SYTL2 Gene

Regulatory Elements for SYTL2 Gene

Enhancers for SYTL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYTL2 on UCSC Golden Path with GeneCards custom track

Promoters for SYTL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SYTL2 Gene

Chromosome:
11
Start:
85,694,221 bp from pter
End:
85,811,159 bp from pter
Size:
116,939 bases
Orientation:
Minus strand

Genomic View for SYTL2 Gene

Genes around SYTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL2 Gene

Proteins for SYTL2 Gene

  • Protein details for SYTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCH5-SYTL2_HUMAN
    Recommended name:
    Synaptotagmin-like protein 2
    Protein Accession:
    Q9HCH5
    Secondary Accessions:
    • B3KRS3
    • B4DJT5
    • B4DKW3
    • B4DQ26
    • B7SA85
    • B7ZLX6
    • B7ZLX7
    • Q2YDA7
    • Q6TV07
    • Q6ZN59
    • Q6ZVC5
    • Q8ND34
    • Q96BJ2
    • Q9H768
    • Q9NXM1

    Protein attributes for SYTL2 Gene

    Size:
    934 amino acids
    Molecular mass:
    104930 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by GTP-binding.
    SequenceCaution:
    • Sequence=AAR25619.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA90989.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB13423.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13423.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305}; Sequence=BAB13423.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=BAD18516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYTL2 Gene

    Alternative splice isoforms for SYTL2 Gene

neXtProt entry for SYTL2 Gene

Post-translational modifications for SYTL2 Gene

  • Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYTL2 Gene

Domains & Families for SYTL2 Gene

Protein Domains for SYTL2 Gene

Suggested Antigen Peptide Sequences for SYTL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCH5

UniProtKB/Swiss-Prot:

SYTL2_HUMAN :
  • The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL).
Domain:
  • The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL).
  • The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2) and localization to the cell membrane.
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL2: view

Function for SYTL2 Gene

Molecular function for SYTL2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Gene Ontology (GO) - Molecular Function for SYTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IMP 17182843
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 15231748
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IMP 17182843
genes like me logo Genes that share ontologies with SYTL2: view
genes like me logo Genes that share phenotypes with SYTL2: view

Animal Models for SYTL2 Gene

MGI Knock Outs for SYTL2:

Animal Model Products

CRISPR Products

miRNA for SYTL2 Gene

miRTarBase miRNAs that target SYTL2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYTL2 Gene

Localization for SYTL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL2 Gene

Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. {ECO:0000269 PubMed:18812475}.
Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269 PubMed:17182843}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL2 Gene COMPARTMENTS Subcellular localization image for SYTL2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SYTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18812475
GO:0005886 plasma membrane IDA 17182843
GO:0016020 membrane ISS --
GO:0019897 extrinsic component of plasma membrane ISS --
GO:0042470 melanosome ISS --
genes like me logo Genes that share ontologies with SYTL2: view

Pathways & Interactions for SYTL2 Gene

genes like me logo Genes that share pathways with SYTL2: view

Pathways by source for SYTL2 Gene

Interacting Proteins for SYTL2 Gene

Gene Ontology (GO) - Biological Process for SYTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IDA 18812475
GO:0006904 vesicle docking involved in exocytosis IDA 18812475
GO:0006906 vesicle fusion IBA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with SYTL2: view

No data available for SIGNOR curated interactions for SYTL2 Gene

Drugs & Compounds for SYTL2 Gene

(1) Drugs for SYTL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SYTL2: view

Transcripts for SYTL2 Gene

Unigene Clusters for SYTL2 Gene

Synaptotagmin-like 2:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - -
SP9:
SP10: - - - - - - - - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - -
SP14:
SP15:
SP16: - - - -
SP17: - - - -
SP18:
SP19: - - - -

ExUns: 14c ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - -
SP10: - -
SP11: - -
SP12: - -
SP13: - -
SP14: - -
SP15:
SP16: - -
SP17: - - -
SP18: -
SP19:

Relevant External Links for SYTL2 Gene

GeneLoc Exon Structure for
SYTL2
ECgene alternative splicing isoforms for
SYTL2

Expression for SYTL2 Gene

mRNA expression in normal human tissues for SYTL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for SYTL2 Gene

This gene is overexpressed in Liver (46.8) and Nasal epithelium (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYTL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SYTL2 Gene:

SYTL2

SOURCE GeneReport for Unigene cluster for SYTL2 Gene:

Hs.369520

mRNA Expression by UniProt/SwissProt for SYTL2 Gene:

Q9HCH5-SYTL2_HUMAN
Tissue specificity: Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
genes like me logo Genes that share expression patterns with SYTL2: view

Primer Products

No data available for Protein tissue co-expression partners for SYTL2 Gene

Orthologs for SYTL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sytl2 34
  • 77.17 (n)
  • 66.94 (a)
Sytl2 16
Sytl2 35
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYTL2 34
  • 99.82 (n)
  • 99.73 (a)
SYTL2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sytl2 34
  • 76.96 (n)
  • 65.82 (a)
cow
(Bos Taurus)
Mammalia SYTL2 35
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYTL2 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYTL2 35
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYTL2 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYTL2 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYTL2 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15401 34
zebrafish
(Danio rerio)
Actinopterygii SYTL2 (1 of 3) 35
  • 26 (a)
OneToMany
SYTL2 (2 of 3) 35
  • 32 (a)
OneToMany
sytl2b 35
  • 19 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7343 36
  • 41 (a)
btsz 35
  • 8 (a)
OneToMany
Species where no ortholog for SYTL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL2 Gene

ENSEMBL:
Gene Tree for SYTL2 (if available)
TreeFam:
Gene Tree for SYTL2 (if available)

Paralogs for SYTL2 Gene

Paralogs for SYTL2 Gene

genes like me logo Genes that share paralogs with SYTL2: view

Variants for SYTL2 Gene

Sequence variations from dbSNP and Humsavar for SYTL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1140983 -- 85,698,075(-) TGGTA(A/G)AAAGC reference, missense
rs1144762 -- 85,735,758(-) ttttt(G/T)ggcca intron-variant
rs1151152 -- 85,785,249(+) ATTCT(A/C)AACAA intron-variant
rs1213587 -- 85,733,623(+) AGTCT(C/T)GCTCT intron-variant
rs1237204 -- 85,733,663(+) ggcgc(A/C)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL2 Gene

Variant ID Type Subtype PubMed ID
dgv1245n100 CNV loss 25217958
dgv1246n100 CNV loss 25217958
dgv2040n54 CNV loss 21841781
esv1951703 CNV deletion 18987734
esv2659539 CNV deletion 23128226
esv2674430 CNV deletion 23128226
esv2744849 CNV deletion 23290073
esv2744850 CNV deletion 23290073
esv2759845 CNV gain+loss 17122850
esv2762927 CNV gain 21179565
esv3579778 CNV loss 25503493
esv3627072 CNV loss 21293372
esv3627074 CNV loss 21293372
nsv1035489 CNV gain 25217958
nsv1049630 CNV gain 25217958
nsv1113416 CNV deletion 24896259
nsv1119897 CNV deletion 24896259
nsv417 CNV insertion 18451855
nsv468768 CNV loss 19166990
nsv528829 CNV loss 19592680
nsv555632 CNV loss 21841781
nsv555638 CNV loss 21841781
nsv555639 CNV loss 21841781
nsv555640 CNV loss 21841781
nsv832222 CNV gain 17160897

Variation tolerance for SYTL2 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYTL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL2 Gene

Disorders for SYTL2 Gene

Relevant External Links for SYTL2

Genetic Association Database (GAD)
SYTL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL2

No disorders were found for SYTL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL2 Gene

Publications for SYTL2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 65
  2. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PMID: 18266782) Holt O. … Griffiths G.M. (Traffic 2008) 3 4 65
  3. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion. (PMID: 18812475) Menasche G. … de Saint Basile G. (Blood 2008) 3 4 65
  4. Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. (PMID: 18940603) Chavas L.M. … Wakatsuki S. (Structure 2008) 3 4 65
  5. Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. (PMID: 17182843) Yu M. … Izumi T. (Mol. Biol. Cell 2007) 3 4 65

Products for SYTL2 Gene

Sources for SYTL2 Gene

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