Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYTL2 Gene

protein-coding GIFtS: 56
GCID: GC11M085405

synaptotagmin-like 2

Explore 8 diseases affiliated with
SYTL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin-Like 2¹ ²		EXO4² ⁵
SLP2¹ ² ³ ⁵		FLJ20163¹
SGA72M¹ ² ³		FLJ21219¹
KIAA1597¹ ³ ⁵		MGC102768¹
SLP2A² ³ ⁵		Chromosome 11 Synaptotagmin²
CHR11SYT¹ ²		Synaptotagmin-Like Protein 2²
Exophilin-4³		Exophilin-4³
Breast Cancer-Associated Antigen SGA-72M² ³

External Ids:	HGNC: 15585¹	Entrez Gene: 54843²	Ensembl: ENSG00000137501⁷	OMIM: 612880⁵	UniProtKB: Q9HCH5³

Export aliases for SYTL2 gene to outside databases

Previous GC identifers: GC11M087732 GC11M086944 GC11M085628 GC11M085131 GC11M085082 GC11M081702

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYTL2:

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein

family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of

Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls

melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding

distinct isoforms.(provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5

Function: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes.

It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and

phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell

membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive

Gene Wiki entry for SYTL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYTL2 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 SREBP-1b SREBP-1a E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYTL2 promoter sequence

Search SABiosciences Chromatin IP Primers for SYTL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1

SYTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M085405: view genomic region (about GC identifiers)

Start:	85,405,264 bp from pter	End:	85,522,184 bp from pter
Size:	116,921 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5 (See protein sequence)

Recommended Name: Synaptotagmin-like protein 2

Size: 934 amino acids; 104930 Da

Subunit: Monomer. Binds NRXN1. Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by

GTP-binding

Subcellular location: Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic

T-lymphocytes (CTL) by RAB27A

Subcellular location: Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and

anterior regions. Localizes on the glucagon granules in the cell periphery

Sequence caution: Sequence=AAR25619.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAA90989.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAB13423.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13423.1; Type=Frameshift; Positions=13;

Sequence=BAB13423.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=BAD18516.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for SYTL2:

3BC1 (3D)

Secondary accessions: B3KRS3 B4DJT5 B4DKW3 B4DQ26 B7SA85 B7ZLX6 B7ZLX7 Q2YDA7 Q6TV07 Q6ZN59 Q6ZVC5

Q8ND34 Q96BJ2 Q9H768 Q9NXM1

Alternative splicing: 12 isoforms: Q9HCH5-1 Q9HCH5-2 Q9HCH5-4 Q9HCH5-6 Q9HCH5-7 Q9HCH5-8 Q9HCH5-9 Q9HCH5-11

Q9HCH5-12 Q9HCH5-13 Q9HCH5-14 Q9HCH5-15 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL2: NX_Q9HCH5

Post-translational modifications:

Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCH5

SYTL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_001156423.1 NP_001156424.1 NP_001156425.1 NP_115755.2 NP_116561.1 NP_996810.1 NP_996811.1 NP_996812.1

NP_996813.1

ENSEMBL proteins:

ENSP00000436678 ENSP00000346576 ENSP00000318803 ENSP00000432996 ENSP00000432694

ENSP00000374609 ENSP00000435855 ENSP00000374608 ENSP00000435009 ENSP00000431701

ENSP00000432144 ENSP00000434010 ENSP00000435238 ENSP00000436164 ENSP00000437005

ENSP00000432137 ENSP00000434882 ENSP00000434111 ENSP00000431703 ENSP00000432116

ENSP00000434621 ENSP00000374610 ENSP00000352065

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): SYTL2 OriGene Protein Over-expression Lysate (see all 7): SYTL2 OriGene Custom Protein Services for SYTL2
	GenScript Custom Purified and Recombinant Proteins Services for SYTL2
	Novus Biologicals SYTL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYTL2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005886	plasma membrane	IDA	--

SYTL2 for ontologies About GeneDecksing

SYTL2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SYTL2
	GenScript Custom Superior Antibodies Services for SYTL2
	Novus Biologicals SYTL2 Antibody
	Search for Antibodies for SYTL2 at Abcam
	Uscn Antibodies for SYTL2
	ThermoFisher Antibody for SYTL2

Assay Products for SYTL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYTL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYTL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYTL2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR018029 C2_membr_targeting

IPR013083 Znf_RING/FYVE/PHD

IPR027006 SYTL2

IPR011011 Znf_FYVE_PHD

Graphical View of Domain Structure for InterPro Entry Q9HCH5

ProtoNet protein and cluster: Q9HCH5

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5

Domain: The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic

T-lymphocytes (CTL)

Domain: The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2)

and localization to the cell membrane

Similarity: Contains 2 C2 domains

Similarity: Contains 1 RabBD (Rab-binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5

Function: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes.

It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and

phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell

membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive

miRNA Products:		OriGene 3'-UTR Clone (see all 9): SYTL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL2
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL2 (see all 14):
		hsa-miR-194* hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-15a hsa-miR-765 hsa-miR-497 hsa-miR-3647-3p hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SYTL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL2 (see all 7) OriGene shRNA RFP: SYTL2 OriGene siRNA: SYTL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SYTL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2 (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): SYTL2 (NM_206927)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYTL2
		Search LifeMap BioReagents cell lines for SYTL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	phosphatidylserine binding	IMP	17182843
GO:0005215	transporter activity	--	--
GO:0005515	protein binding	IPI	18940603
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IMP	17182843
GO:0017137	Rab GTPase binding	IEA	--

SYTL2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SYTL2:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Sytl2^tm1Mitf for SYTL2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sytl2):

digestive/alimentary

SYTL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

1.00

1 BioSystems Pathway for SYTL2

Deregulation of Rab and Rab Effector Genes in Bladder Cancer

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SYTL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for SYTL2 (Q9HCH5^{2, 3} ENSP00000346576⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CA	P62136²^,³, ENSP00000326031⁴	MINT-62209 I2D: score=3 STRING: ENSP00000326031
RAB27B	O00194³, ENSP00000262094⁴	I2D: score=1 STRING: ENSP00000262094
RPAP1	Q9BWH6³, ENSP00000306123⁴	I2D: score=1 STRING: ENSP00000306123
RAB27A	P51159³, ENSP00000337761⁴	I2D: score=5 STRING: ENSP00000337761
NRXN1	Q9ULB1³, ENSP00000385142⁴	I2D: score=2 STRING: ENSP00000385142

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006887	exocytosis	IDA	18812475
GO:0006904	vesicle docking involved in exocytosis	IDA	18812475
GO:0010923	negative regulation of phosphatase activity	IDA	19389623
GO:0016192	vesicle-mediated transport	ISS	--

SYTL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYTL2

1 HMDB Compound for SYTL2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about SYTL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYTL2 gene (9 alternative transcripts):

NM_001162951.1 NM_001162952.1 NM_001162953.1 NM_032379.3 NM_032943.3 NM_206927.2 NM_206928.2 NM_206929.2

NM_206930.2

Unigene Cluster for SYTL2:

Synaptotagmin-like 2

Hs.369520 [show with all ESTs]

Unigene Representative Sequence: AY386362

18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):

ENST00000532995(uc010rte.2 uc001paz.3 uc001pay.3 uc001paw.3)

ENST00000354566 ENST00000316356(uc010rtg.2 uc010rth.2 uc010rtj.2)

ENST00000525702(uc001pav.3) ENST00000525423 ENST00000389959(uc009yvj.3)

ENST00000529581 ENST00000389958 ENST00000530351 ENST00000528231 ENST00000531496

ENST00000525692 ENST00000533892 ENST00000527523 ENST00000524452 ENST00000529662

ENST00000533057 ENST00000527794

miRNA Products:		OriGene 3'-UTR Clone (see all 9): SYTL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL2
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SYTL2 (see all 14):
		hsa-miR-194* hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-15a hsa-miR-765 hsa-miR-497 hsa-miR-3647-3p hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: SYTL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL2 (see all 7) OriGene shRNA RFP: SYTL2 OriGene siRNA: SYTL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2 (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): SYTL2 (NM_206927)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYTL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL2

Additional cDNA sequence:

AB046817.1 AJ303364.1 AK024872.1 AK074737.1 AK092121.1 AK124754.1 AK127504.1 AK131365.1

AK222707.1 AK222710.1 AK296224.1 AK296740.1 AK298604.1 AL834422.1 AY386362.1 BC015540.2

BC068495.1 BC110315.1 BC136450.1 BC144114.1 BC144115.1 BX647671.1 BX648068.1 EU035829.1

24/31 DOTS entries (see all 31):

DT.100699958 DT.101981641 DT.100024544 DT.100748721 DT.100024543 DT.100748722 DT.91864902 DT.445411

DT.97845457 DT.100804612 DT.86855129 DT.100751304 DT.120708322 DT.86843529 DT.101981639 DT.100694538

DT.40120219 DT.95333360 DT.95355402 DT.97781882 DT.100694537 DT.100735888 DT.120708305 DT.120708325

24/201 AceView cDNA sequences (see all 201):

AI382731 BE677817 CB046276 BF221732 NM_206929 AW188162 AA909368 AA494316

NM_206930 AW772198 BM987413 BM983356 BM875478 AI823970 AW771139 AA327078

BI757595 AA831925 BM745134 BM857510 BU947573 AI587601 AW593965 AA825498

GeneLoc Exon Structure

5/19 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL2 (see all 19) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	·
SP1:															-				-		-		-				-		-		-		-		-		-		-				-				-		-		-
SP2:																											-		-		-		-		-		-		-								-		-		-
SP3:																											-		-		-		-		-		-		-				-				-		-		-
SP4:																											-		-		-		-		-		-		-				-		-		-		-		-
SP5:																											-		-		-		-		-		-		-				-				-		-		-

ExUns:	14c	^	15a	·	15b	·	15c	·	15d	·	15e	^	16	^	17a	·	17b	·	17c	·	17d	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23a	·	23b	·	23c
SP1:	-		-										-												-				-
SP2:	-		-																						-				-
SP3:	-		-																						-				-
SP4:	-		-																						-				-
SP5:	-		-										-												-				-

ECgene alternative splicing isoforms for SYTL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYTL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGCAACA

About this image

SYTL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Intermediate Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

See SYTL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYTL2

SOURCE GeneReport for Unigene cluster: Hs.369520

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5

Tissue specificity: Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8

T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in

nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells

SABiosciences Custom PCR Arrays for SYTL2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYTL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYTL2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SYTL2¹	synaptotagmin-like 2	55.25(n) 44.42(a)		426394 XM_424045.3 XP_424045.3
lizard (Anolis carolinensis)	Reptilia	SYTL2⁶	--	45(a)	1 ↔ 1	3(200602444-200653589)
African clawed frog (Xenopus laevis)	Amphibia	CD329598.1²	--	76.94(n)		CD329598.1
zebrafish (Danio rerio)	Actinopterygii	LOC563188¹	synaptotagmin-like protein 2-like	63.38(n) 56.96(a)		563188 XM_686549.4 XP_691641.4
fruit fly (Drosophila melanogaster)	Insecta	CG7343³	synaptic vesicle endocytosis protein transporter	41(a)		88D4 --
worm (Caenorhabditis elegans)	Secernentea	snt-6⁶	SyNapTotagmin family member (snt-6)	18(a)	possible ortholog	II(745469-750171)

ENSEMBL Gene Tree for SYTL2 (if available)
TreeFam Gene Tree for SYTL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYTL2 gene

SYTL4² DOC2B² SYTL5² SYTL1² DOC2A² SYTL3² RPH3A²

18/20 SIMAP similar genes for SYTL2 using alignment to 12 protein entries: SYTL2_HUMAN (see all proteins) (see all similar genes):

CHR11SYT TBCB IK GALK2 SYT9 SYTL1

PRKCB SYT10 SYTL3 SYTL4 LSM12 PIK3C2A

PRKCG PIK3C2B DOC2A PCLO SYT7 PRKCA

SYTL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58970082^1,2	C,	--	81702188(+)	`AGTCAC/ATCTTA`	9	--	ds500¹		1	WA	2
rs1658^1,2	C,F,H,	--	81702864(+)	`GCAGGG/ATTTTA`	9	--	ut3¹ ese³		12	MN NA NS EA	1476
rs11424605^1,2	C	--	81703105(+)	`TTTTTT/-ATCAT`	9	--	ut3¹ trp³		1	NA	2
rs77020006^1,2	C,F,	--	81703374(+)	`NNNNTA/GTTAGA`	9	--	ut3¹		1	NA	120
rs113014722^1,2		--	81703812(+)	`TATAAC/ACACCA`	9	--	int¹		1	CSA	2
rs113300110^1,2	F,	--	81706264(+)	`TCATTC/TAAATT`	9	--	int¹		2	CSA	5
rs78176888^1,2	F,	--	81706523(+)	`ATACTG/TCGTCC`	9	--	int¹		1	WA	118
rs116094184^1,2	C,F,	--	81706557(+)	`CTGGCA/GTGGAG`	9	--	int¹		1	WA	118
rs112188912^1,2		--	81706689(+)	`AAGTAC/TCAAGT`	9	--	int¹		1	CSA	2
rs77294543^1,2	C,	--	81707289(+)	`TATGGG/ACAGAT`	9	--	int¹		2	WA	120

HapMap Linkage Disequilibrium report for SYTL2 (85405264 - 85522184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SYTL2
2 CNVs: 2940 3860
1 Indel: 44945

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYTL2

DNA2.0 Custom Variant and Variant Library Synthesis for SYTL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYTL2 for disorders           About GeneDecksing

OMIM gene information: 612880    OMIM disorders: --

8 diseases for SYTL2:    About MalaCards

breast cancer laryngeal squamous cell carcinoma squamous cell carcinoma laryngitis

carcinoma esophagitis pancreatitis neuronitis

Export disorders for SYTL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYTL2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with SYTL2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2, 3} Nagase T.... Ohara O. (2000)
A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion. (PubMed id 18812475)^{1, 2} Menasche G....de Saint Basile G. (2008)
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)^{1, 2} Holt O....Griffiths G.M. (2008)
Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. (PubMed id 18940603)^{1, 2} Chavas L.M.... Wakatsuki S. (2008)
Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. (PubMed id 17182843)^{1, 2} Yu M.... Izumi T. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
[Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma]. (PubMed id 20654157)¹ Cao W.F....Sun B.C. (2010)
Calmodulin suppresses synaptotagmin-2 transcription i n cortical neurons. (PubMed id 20729199)¹ Pang Z.P....SA1dhof T.C. (2010)
[Expression of SLP-2 protein in esophageal squamous c ell carcinoma is associated with cancer invasion]. (PubMed id 21223688)¹ Cao W.F....Sun B.C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54843	HGNC: 15585	AceView: SYTL2	Ensembl:ENSG00000137501	euGenes: HUgn54843
ECgene: SYTL2	H-InvDB: SYTL2

(According to HUGE)
About This Section

HUGE: KIAA1597

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYTL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYTL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYTL2 gene:
Search GeneIP for patents involving SYTL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SYTL2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL2
	OriGene Protein Over-expression Lysate for SYTL2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SYTL2		OriGene 3'-UTR Clone for SYTL2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SYTL2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SYTL2		OriGene Custom Protein Services for SYTL2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYTL2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYTL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL2

	GenScript Custom Purified and Recombinant Proteins Services for SYTL2		GenScript cDNA clones with any tag delivered in your preferred vector for SYTL2
	GenScript Custom Assay Services for SYTL2		GenScript Custom Superior Antibodies Services for SYTL2
	GenScript Custom overexpressing Cell Line Services for SYTL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SYTL2 promoter
	Search Chromatin IP Primers for SYTL2
	RT² qPCR Primer Assay in human, mouse, rat SYTL2
	GNC Network for SYTL2
	SABiosciences Custom PCR Arrays for SYTL2

Search Tocris compounds for SYTL2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SYTL2 antibodies
	SYTL2 lysates

	Search for Antibodies for SYTL2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SYTL2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SYTL2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SYTL2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL2

	SwitchGear 3'UTR luciferase reporter plasmids for SYTL2
	SwitchGear Promoter luciferase reporter plasmids for SYTL2

ThermoFisher Antibody for SYTL2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYTL2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SYTL2 Gene

synaptotagmin-like 2

Aliases
for SYTL2 gene

Summaries
for SYTL2 gene

Genomic Views
for SYTL2 gene

Proteins
for SYTL2 gene

Protein Domains /
Families
for SYTL2 gene

Function
for SYTL2 gene

Pathways & Interactions
for SYTL2 gene

Drugs & Compounds
for SYTL2 gene

Transcripts
for SYTL2 gene

Expression
for SYTL2 gene

Orthologs
for SYTL2 gene

Paralogs
for SYTL2 gene

Genomic Variants
for SYTL2 gene

Disorders / Diseases
for SYTL2 gene

Publications
for SYTL2 gene

External Searches for SYTL2 gene

Genome Databases showing SYTL2 gene

Other Databases showing SYTL2 gene

Specialized Databases showing SYTL2 gene

Intellectual Property
for SYTL2 gene

Products
for SYTL2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SYTL2 Gene

synaptotagmin-like 2

Aliasesfor SYTL2 gene

Summariesfor SYTL2 gene

Genomic Viewsfor SYTL2 gene

Proteinsfor SYTL2 gene

Protein Domains /Familiesfor SYTL2 gene

Functionfor SYTL2 gene

Pathways & Interactionsfor SYTL2 gene

Drugs & Compoundsfor SYTL2 gene

Transcriptsfor SYTL2 gene

Expression for SYTL2 gene

Orthologsfor SYTL2 gene

Paralogsfor SYTL2 gene

Genomic Variantsfor SYTL2 gene

Disorders / Diseasesfor SYTL2 gene

Publicationsfor SYTL2 gene

External Searches for SYTL2 gene

Genome Databases showing SYTL2 gene

Other Databases showing SYTL2 gene

Specialized Databases showing SYTL2 gene

Intellectual Propertyfor SYTL2 gene

Productsfor SYTL2 gene

View Random Gene

Aliases
for SYTL2 gene

Summaries
for SYTL2 gene

Genomic Views
for SYTL2 gene

Proteins
for SYTL2 gene

Protein Domains /
Families
for SYTL2 gene

Function
for SYTL2 gene

Pathways & Interactions
for SYTL2 gene

Drugs & Compounds
for SYTL2 gene

Transcripts
for SYTL2 gene

Expression
for SYTL2 gene

Orthologs
for SYTL2 gene

Paralogs
for SYTL2 gene

Genomic Variants
for SYTL2 gene

Disorders / Diseases
for SYTL2 gene

Publications
for SYTL2 gene

Intellectual Property
for SYTL2 gene

Products
for SYTL2 gene