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SYTL2 Gene

protein-coding   GIFtS: 57
GCID: GC11M085405

Synaptotagmin-Like 2

  See SYTL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin-Like 21 2     EXO42 5
Breast Cancer-Associated Antigen SGA-72M1 2 3     KIAA15973 5
SLP22 3 5     CHR11SYT2
SLP2A2 3 5     exophilin-42
Chromosome 11 Synaptotagmin1 2     Synaptotagmin-Like Protein 22
SGA72M2 3     Exophilin-43

External Ids:    HGNC: 155851   Entrez Gene: 548432   Ensembl: ENSG000001375017   OMIM: 6128805   UniProtKB: Q9HCH53   

Export aliases for SYTL2 gene to outside databases

Previous GC identifers: GC11M087732 GC11M086944 GC11M085628 GC11M085131 GC11M085082 GC11M081702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYTL2 Gene:
The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing
protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound
form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking
and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.(provided by RefSeq, Jun 2009)

GeneCards Summary for SYTL2 Gene:
SYTL2 (synaptotagmin-like 2) is a protein-coding gene. Diseases associated with SYTL2 include breast cancer. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and Rab GTPase binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5
Function: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in
lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds
phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of
glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+)
while binding to PIP2 is Ca(2+) insensitive

Gene Wiki entry for SYTL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYTL2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   SREBP-1b   SREBP-1a   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYTL2 promoter sequence
   Search Chromatin IP Primers for SYTL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

SYTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M085405:  view genomic region     (about GC identifiers)

Start:
85,405,264 bp from pter      End:
85,522,184 bp from pter
Size:
116,921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 2  
Size: 934 amino acids; 104930 Da
Subunit: Monomer. Binds NRXN1. Interacts with RAB27B (By similarity). Binds RAB27A that has been activated by
GTP-binding
Sequence caution: Sequence=AAR25619.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA90989.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAB13423.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13423.1; Type=Frameshift;
Positions=13; Sequence=BAB13423.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=BAD18516.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for SYTL2:
3BC1 (3D)    
Secondary accessions: B3KRS3 B4DJT5 B4DKW3 B4DQ26 B7SA85 B7ZLX6 B7ZLX7 Q2YDA7 Q6TV07 Q6ZN59
Q6ZVC5 Q8ND34 Q96BJ2 Q9H768 Q9NXM1
Alternative splicing: 12 isoforms:  Q9HCH5-1   Q9HCH5-2   Q9HCH5-4   Q9HCH5-6   Q9HCH5-7   Q9HCH5-8   Q9HCH5-9   Q9HCH5-11   
Q9HCH5-12   Q9HCH5-13   Q9HCH5-14   Q9HCH5-15   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL2: NX_Q9HCH5

Explore proteomics data for SYTL2 at MOPED

Post-translational modifications: 

  • Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYTL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (12 alternative transcripts): 
    NP_001156423.1  NP_001156424.1  NP_001156425.1  NP_001276537.1  NP_001276538.1  NP_001276539.1  NP_116561.1  NP_996812.1  
    NP_996813.1  NP_115755.2  NP_996810.1  NP_996811.1  

    ENSEMBL proteins: 
     ENSP00000436678   ENSP00000346576   ENSP00000318803   ENSP00000432996   ENSP00000432694  
     ENSP00000374609   ENSP00000435855   ENSP00000374608   ENSP00000435009   ENSP00000431701  
     ENSP00000432144   ENSP00000434010   ENSP00000435238   ENSP00000436164   ENSP00000437005  
     ENSP00000432137   ENSP00000434111   ENSP00000431703   ENSP00000432116   ENSP00000434621  
     ENSP00000374610   ENSP00000352065  

    SYTL2 Human Recombinant Protein Products:

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    Novus Biologicals SYTL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYTL2

     
    Search eBioscience for Proteins for SYTL2 

     
    Search antibodies-online for proteins for SYTL2 

     
    antibodies-online peptides for SYTL2

    SYTL2 Antibody Products:

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    ThermoFisher Antibody for SYTL2
    antibodies-online antibodies for SYTL2 (7 products) 

    SYTL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYTL2
    Cloud-Clone Corp. CLIAs for SYTL2
    Search eBioscience for ELISAs for SYTL2 
    antibodies-online kits for SYTL2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013083 Znf_RING/FYVE/PHD
     IPR027006 SYTL2
     IPR000008 C2_dom
     IPR010911 Znf_FYVE-typ

    Graphical View of Domain Structure for InterPro Entry Q9HCH5

    ProtoNet protein and cluster: Q9HCH5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5
    Domain: The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic
    T-lymphocytes (CTL)
    Domain: The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate
    (PIP2) and localization to the cell membrane
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 RabBD (Rab-binding) domain


    Find genes that share domains with SYTL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL2_HUMAN, Q9HCH5
    Function: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in
    lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds
    phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of
    glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+)
    while binding to PIP2 is Ca(2+) insensitive

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IMP17182843
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI15231748
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IMP17182843
    GO:0017137Rab GTPase binding IEA--
         
    Find genes that share ontologies with SYTL2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYTL2:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sytl2):
     digestive/alimentary 

    Find genes that share phenotypes with SYTL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sytl2tm1Mitf for SYTL2

       genOway: Develop your customized and physiologically relevant rodent model for SYTL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYTL2:
    hsa-mir-1 (MIRT023665)

    Block miRNA regulation of human, mouse, rat SYTL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYTL2 (see all 14):
    hsa-miR-194* hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-15a hsa-miR-765 hsa-miR-497 hsa-miR-3647-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSYTL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYTL2
    Predesigned siRNA for gene silencing in human, mouse, rat SYTL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYTL2

    Clone
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    OriGene clones in human, mouse for SYTL2 (see all 53)
    OriGene ORF clones in mouse, rat for SYTL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): SYTL2 (NM_206927)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL2
    Addgene plasmids for SYTL2 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYTL2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTL2_HUMAN, Q9HCH5: Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic
    T-lymphocytes (CTL) by RAB27A
    SYTL2_HUMAN, Q9HCH5: Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral
    and anterior regions. Localizes on the glucagon granules in the cell periphery
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    nucleus4
    cytosol3
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--
    GO:0008021synaptic vesicle ----

    Find genes that share ontologies with SYTL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYTL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL2
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYTL2
    Interactions:

        GeneGlobe Interaction Network for SYTL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SYTL2 (Q9HCH51, 2, 3 ENSP000003465764) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621361, 2, 3, ENSP000003260314EBI-2690103,EBI-357253 MINT-62209 I2D: score=3 STRING: ENSP00000326031
    RAB27BO001943, ENSP000002620944I2D: score=1 STRING: ENSP00000262094
    RPAP1Q9BWH63, ENSP000003061234I2D: score=1 STRING: ENSP00000306123
    RAB27AP511593, ENSP000003377614I2D: score=5 STRING: ENSP00000337761
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IDA18812475
    GO:0006904vesicle docking involved in exocytosis IDA18812475
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0016192vesicle-mediated transport ISS--

    Find genes that share ontologies with SYTL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYTL2

    1 HMDB Compound for SYTL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYTL2 gene (12 alternative transcripts): 
    NM_001162951.2  NM_001162952.2  NM_001162953.2  NM_001289608.1  NM_001289609.1  NM_001289610.1  NM_032943.4  NM_206929.3  
    NM_206930.3  NM_032379.3  NM_206927.2  NM_206928.2  

    Unigene Cluster for SYTL2:

    Synaptotagmin-like 2
    Hs.369520  [show with all ESTs]
    Unigene Representative Sequence: AY386362
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000532995(uc010rte.2 uc001paz.3 uc001pay.3 uc001paw.3)
    ENST00000354566 ENST00000316356(uc010rtg.2 uc010rth.2 uc010rtj.2)
    ENST00000525702(uc001pav.3) ENST00000525423 ENST00000389959(uc009yvj.3)
    ENST00000529581 ENST00000389958 ENST00000530351 ENST00000528231 ENST00000531496
    ENST00000525692 ENST00000533892 ENST00000527523 ENST00000524452 ENST00000529662
    ENST00000533057 ENST00000527794
    miRNA
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    Block miRNA regulation of human, mouse, rat SYTL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYTL2 (see all 14):
    hsa-miR-194* hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-15a hsa-miR-765 hsa-miR-497 hsa-miR-3647-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSYTL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYTL2
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    GenScript: all cDNA clones in your preferred vector (see all 9): SYTL2 (NM_206927)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL2
    Addgene plasmids for SYTL2 
    Primer
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    OriGene qPCR primer pairs and template standards for SYTL2
    OriGene qSTAR qPCR primer pairs in human, mouse for SYTL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYTL2
      QuantiTect SYBR Green Assays in human, mouse, rat SYTL2
      QuantiFast Probe-based Assays in human, mouse, rat SYTL2

    Additional mRNA sequence: 

    AB046817.1 AJ303364.1 AK024872.1 AK074737.1 AK092121.1 AK124754.1 AK127504.1 AK131365.1 
    AK222707.1 AK222710.1 AK296224.1 AK296740.1 AK298604.1 AL834422.1 AY386362.1 BC015540.2 
    BC068495.1 BC110315.1 BC136450.1 BC144114.1 BC144115.1 BX647671.1 BX648068.1 EU035829.1 

    Selected DOTS entries (see all 31):

    DT.100699958  DT.101981641  DT.100024544  DT.100748721  DT.100024543  DT.100748722  DT.91864902  DT.445411 
    DT.97845457  DT.100804612  DT.86855129  DT.100751304  DT.120708322  DT.86843529  DT.101981639  DT.100694538 
    DT.40120219  DT.95333360  DT.95355402  DT.97781882  DT.100694537  DT.100735888  DT.120708305  DT.120708325 

    Selected AceView cDNA sequences (see all 201):

    AI587601 AW593965 AW771139 BM983356 BE328714 BM771122 AA600712 AA494316 
    AJ303364 BU947573 CB046276 NM_206927 BE677817 AA327078 NM_032943 AW772198 
    AI337806 AA825498 AA909368 BM857510 AA831925 AI806021 BQ082766 AA748463 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYTL2 (see all 19)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ·
    SP1:                                            -           -     -     -           -     -     -     -     -     -     -           -           -     -     -   
    SP2:                                                                                -     -     -     -     -     -     -                       -     -     -   
    SP3:                                                                                -     -     -     -     -     -     -           -           -     -     -   
    SP4:                                                                                -     -     -     -     -     -     -           -     -     -     -     -   
    SP5:                                                                                -     -     -     -     -     -     -           -           -     -     -   

    ExUns: 14c ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:  -     -                             -                                   -           -                                       
    SP2:  -     -                                                                 -           -                                       
    SP3:  -     -                                                                 -           -                                       
    SP4:  -     -                                                                 -           -                                       
    SP5:  -     -                             -                                   -           -                                       


    ECgene alternative splicing isoforms for SYTL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SYTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGCAACA
    SYTL2 Expression
    About this image


    SYTL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Oligodendrocyte-like cells
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    SYTL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYTL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369520

    UniProtKB/Swiss-Prot: SYTL2_HUMAN, Q9HCH5
    Tissue specificity: Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8
    T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in
    nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYTL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl21 , 5 synaptotagmin-like 21, 5 77.17(n)1
    66.94(a)1
      7 (50.54 cM)5
    836711  NM_001040086.11  NP_001035175.11 
     903486995 
    chicken
    (Gallus gallus)
    Aves SYTL26
    synaptotagmin-like 2
    41(a)
    1 ↔ 1
    1(189475610-189529781) ENSGALG00000014079
    lizard
    (Anolis carolinensis)
    Reptilia SYTL26
    synaptotagmin-like 2
    41(a)
    1 ↔ 1
    3(200568403-200655089)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD329598.12   -- 76.94(n)    CD329598.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SYTL2 (2 of 3)6
    SYTL2 (1 of 3)6
    (see all 3)
    synaptotagmin-like 2
    (see all 3)
    32(a)
    26(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    10(29983851-30004954) ENSDARG00000061956
    17(15229718-15252224) ENSDARG00000003381
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73433 synaptic vesicle endocytosis protein
    transporter
    41(a)   88D4   --


    ENSEMBL Gene Tree for SYTL2 (if available)
    TreeFam Gene Tree for SYTL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYTL2 gene
    SYTL42  SYTL52  DOC2B2  SYTL12  DOC2A2  SYTL32  RPH3A2  
    Selected SIMAP similar genes for SYTL2 using alignment to 11 protein entries:     SYTL2_HUMAN (see all proteins) (see all similar genes):
    CHR11SYT    IK    GALK2    SYT9    SYTL1    PRKCB
    SYT10    SYTL3    SYTL4    TM2D1    LSM12    PIK3C2A
    PRKCG    PIK3C2B    DOC2A    PCLO    SYT7    PRKCA

    Find genes that share paralogs with SYTL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYTL2 (see all 2495)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585090771,2
    C--81715265(+) CACTCTT/-GTCAC 9 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs1442800151,2
    C--81721084(+) CATAT-/ACACACA 9 -- int10--------
    rs346538491,2
    C--81732348(+) CAATT-/AAAAAA 5 -- int11Minor allele frequency- A:0.50NA 2
    rs671339011,2
    C--81741972(+) CCAAG-/TTTTTT 3 -- int10--------
    rs347954151,2
    C--81755688(+) AAAAA-/AGACAT 3 -- int10--------
    rs350712021,2
    C--81759182(+) CAATG-/AATGGT 3 -- int13Minor allele frequency- A:0.17NA CSA 6
    rs3709950381,2
    C--81762160(+) ttttt-/TAaaaaa 3 -- int11Minor allele frequency- TA:0.00NA 2
    rs114002821,2
    C--81765633(+) AAAAAT/-TTTTT 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs344052141,2
    C--81767922(+) GTACC-/AAAAATAG 6 -- us2k1 cds1 int10--------
    rs342219461,2
    C--81768156(+) ATTAC-/TTCA  
            
    TTTTC
    3 -- us2k1 int11Minor allele frequency- TTCA:0.00CSA 2

    HapMap Linkage Disequilibrium report for SYTL2 (85405264 - 85522184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYTL2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1951703CNV Deletion18987734
    esv2744850CNV Deletion23290073
    esv2659539CNV Deletion23128226
    esv2744849CNV Deletion23290073
    esv2674430CNV Deletion23128226
    nsv417CNV Insertion18451855
    nsv528829CNV Loss19592680
    nsv468768CNV Loss19166990
    nsv898050CNV Loss21882294
    nsv832222CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612880    OMIM disorders: --

    1 disease for SYTL2:    
    About MalaCards
    breast cancer


    Find genes that share disorders with SYTL2           About GenesLikeMe

    Genetic Association Database (GAD): SYTL2

    Export disorders for SYTL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYTL2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with SYTL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion. (PubMed id 18812475)1, 2 Menasche G....de Saint Basile G. (Blood 2008)
    3. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)1, 2 Holt O.... Griffiths G.M. (Traffic 2008)
    4. Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a. (PubMed id 18940603)1, 2 Chavas L.M.... Wakatsuki S. (Structure 2008)
    5. Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. (PubMed id 17182843)1, 2 Yu M.... Izumi T. (Mol. Biol. Cell 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27. (PubMed id 24284068)1 Yasuda T. and Fukuda M. (J. Cell. Sci. 2014)
    9. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    10. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. (PubMed id 22820376)1 GA!lvez-Santisteban M....MartA-n-Belmonte F. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54843 HGNC: 15585 AceView: SYTL2 Ensembl:ENSG00000137501 euGenes: HUgn54843
    ECgene: SYTL2 H-InvDB: SYTL2

    (According to HUGE)
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    HUGE: KIAA1597

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYTL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYTL2 gene:
    Search GeneIP for patents involving SYTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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