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Aliases for SYTL1 Gene

Aliases for SYTL1 Gene

  • Synaptotagmin-Like 1 2 3
  • SLP1 3 4 6
  • Exophilin-7 3 4
  • JFC1 3 6
  • NADPH Oxidase-Related, C2 Domain-Containing Protein 3
  • Synaptotagmin-Like Protein 1 3
  • Protein JFC1 4

External Ids for SYTL1 Gene

Previous GeneCards Identifiers for SYTL1 Gene

  • GC01P027274
  • GC01P027541
  • GC01P027668
  • GC01P025924

Summaries for SYTL1 Gene

GeneCards Summary for SYTL1 Gene

SYTL1 (Synaptotagmin-Like 1) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include Rab GTPase binding and neurexin family protein binding. An important paralog of this gene is DOC2A.

UniProtKB/Swiss-Prot for SYTL1 Gene

  • May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Wiki entry for SYTL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL1 Gene

Genomics for SYTL1 Gene

Regulatory Elements for SYTL1 Gene

Genomic Location for SYTL1 Gene

Start:
27,341,992 bp from pter
End:
27,353,937 bp from pter
Size:
11,946 bases
Orientation:
Plus strand

Genomic View for SYTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL1 Gene

Proteins for SYTL1 Gene

  • Protein details for SYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ3-SYTL1_HUMAN
    Recommended name:
    Synaptotagmin-like protein 1
    Protein Accession:
    Q8IYJ3
    Secondary Accessions:
    • Q5SSC9
    • Q96BB6
    • Q96GU6
    • Q96S89
    • Q96SI0

    Protein attributes for SYTL1 Gene

    Size:
    562 amino acids
    Molecular mass:
    61857 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Binds NCF2.
    SequenceCaution:
    • Sequence=AAH15764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL1 Gene

Proteomics data for SYTL1 Gene at MOPED

Post-translational modifications for SYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYTL1 Gene

No data available for DME Specific Peptides for SYTL1 Gene

Domains for SYTL1 Gene

Protein Domains for SYTL1 Gene

Suggested Antigen Peptide Sequences for SYTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYJ3

UniProtKB/Swiss-Prot:

SYTL1_HUMAN :
  • Q8IYJ3
Domain:
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL1: view

No data available for Gene Families for SYTL1 Gene

Function for SYTL1 Gene

Molecular function for SYTL1 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 18266782
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYTL1: view
genes like me logo Genes that share phenotypes with SYTL1: view

Animal Models for SYTL1 Gene

MGI Knock Outs for SYTL1:

miRNA for SYTL1 Gene

miRTarBase miRNAs that target SYTL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SYTL1 Gene

Localization for SYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL1 Gene COMPARTMENTS Subcellular localization image for SYTL1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18266782
GO:0016020 membrane --
GO:0019897 extrinsic component of plasma membrane ISS --
GO:0042470 melanosome ISS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SYTL1: view

Pathways for SYTL1 Gene

genes like me logo Genes that share pathways with SYTL1: view

Pathways by source for SYTL1 Gene

Gene Ontology (GO) - Biological Process for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IDA 18266782
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
genes like me logo Genes that share ontologies with SYTL1: view

Compounds for SYTL1 Gene

(1) HMDB Compounds for SYTL1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SYTL1: view

Transcripts for SYTL1 Gene

Unigene Clusters for SYTL1 Gene

Synaptotagmin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14: - - -
SP15:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SYTL1 Gene

GeneLoc Exon Structure for
SYTL1
ECgene alternative splicing isoforms for
SYTL1

Expression for SYTL1 Gene

mRNA expression in normal human tissues for SYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL1 Gene

This gene is overexpressed in Whole Blood (7.6), Esophagus - Mucosa (5.4), Pancreas (4.6), and Skin - Not Sun Exposed (Suprapubic) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYTL1 Gene

SOURCE GeneReport for Unigene cluster for SYTL1 Gene Hs.469175

mRNA Expression by UniProt/SwissProt for SYTL1 Gene

Q8IYJ3-SYTL1_HUMAN
Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
genes like me logo Genes that share expressions with SYTL1: view

Orthologs for SYTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL1 35
  • 99.41 (n)
  • 98.75 (a)
SYTL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYTL1 35
  • 86.95 (n)
  • 83.1 (a)
SYTL1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYTL1 35
  • 88.35 (n)
  • 86.63 (a)
SYTL1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sytl1 35
  • 82.59 (n)
  • 82.65 (a)
Sytl1 16
Sytl1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYTL1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sytl1 35
  • 81.68 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 40 (a)
ManyToMany
SYTL1 35
  • 63.71 (n)
  • 57.42 (a)
lizard
(Anolis carolinensis)
Reptilia SYTL1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl1 35
  • 52.45 (n)
  • 50.2 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565707 35
  • 51.62 (n)
  • 47.98 (a)
SYTL1 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta btsz 36
  • 5 (a)
OneToMany
Species with no ortholog for SYTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL1 Gene

ENSEMBL:
Gene Tree for SYTL1 (if available)
TreeFam:
Gene Tree for SYTL1 (if available)

Paralogs for SYTL1 Gene

Paralogs for SYTL1 Gene

Selected SIMAP similar genes for SYTL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYTL1: view

Variants for SYTL1 Gene

Sequence variations from dbSNP and Humsavar for SYTL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8533 -- 27,353,801(-) ACCCA(C/T)TCGCA reference, synonymous-codon
rs10335 -- 27,353,865(-) GAGAG(A/G)GGCTT utr-variant-3-prime
rs1128918 -- 27,353,463(+) CTGGG(A/G)GGCAC synonymous-codon, reference
rs1139986 -- 27,353,870(+) TCTCT(C/T)TCTGG utr-variant-3-prime
rs3813795 -- 27,353,306(+) CAGCC(A/G)GGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SYTL1 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294

Relevant External Links for SYTL1 Gene

HapMap Linkage Disequilibrium report
SYTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL1 Gene

Disorders for SYTL1 Gene

No disorders were found for SYTL1 Gene.

No data available for UniProtKB/Swiss-Prot for SYTL1 Gene

Publications for SYTL1 Gene

  1. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PMID: 16004602) Johnson J.L. … Catz S.D. (Biochem. J. 2005) 3 23
  2. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. (PMID: 19528539) NeumA1ller O. … Smolenski A.P. (Blood 2009) 3 23
  3. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. (PMID: 11278853) McAdara Berkowitz J.K. … Babior B.M. (J. Biol. Chem. 2001) 3 4
  4. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PMID: 18266782) Holt O. … Griffiths G.M. (Traffic 2008) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SYTL1 Gene

Sources for SYTL1 Gene

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