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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYTL1 Gene

protein-coding   GIFtS: 52
GCID: GC01P027668

Synaptotagmin-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin-Like 11 2     NADPH Oxidase-Related, C2 Domain-Containing Protein2
SLP12 3 5     Synaptotagmin-Like Protein 12
JFC12 5     Exophilin-73
exophilin-72     Protein JFC13

External Ids:    HGNC: 155841   Entrez Gene: 849582   Ensembl: ENSG000001427657   OMIM: 6080425   UniProtKB: Q8IYJ33   

Export aliases for SYTL1 gene to outside databases

Previous GC identifers: GC01P027274 GC01P027352 GC01P027541 GC01P025924


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYTL1 Gene: 
SYTL1 (synaptotagmin-like 1) is a protein-coding gene. Diseases associated with SYTL1 include crohn's disease, and prostatitis. GO annotations related to this gene include neurexin family protein binding and Rab GTPase binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate.
Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By
similarity)

Gene Wiki entry for SYTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYTL1 gene promoter:
         USF1   AML1a   Olf-1   POU3F2   YY1   USF-1   IRF-7A   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

SYTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027668:  view genomic region     (about GC identifiers)

Start:
27,668,483 bp from pter      End:
27,680,423 bp from pter
Size:
11,941 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 1  
Size: 562 amino acids; 61857 Da
Subunit: Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By
similarity). Binds NCF2
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane
protein tightly bound to the cytoplasmic side of cellular membranes
Sequence caution: Sequence=AAH15764.1; Type=Erroneous initiation;
Secondary accessions: Q5SSC9 Q96BB6 Q96GU6 Q96S89 Q96SI0
Alternative splicing: 2 isoforms:  Q8IYJ3-1   Q8IYJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL1: NX_Q8IYJ3

Explore proteomics data for SYTL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYJ3

  • SYTL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYTL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180237.1  NP_116261.1  

    ENSEMBL proteins: 
     ENSP00000316464   ENSP00000420110   ENSP00000440704  

    Human Recombinant Protein Products for SYTL1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYTL1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA18266782
    GO:0016020membrane ----
    GO:0019897extrinsic to plasma membrane ISS--
    GO:0042470melanosome ISS--

    SYTL1 for ontologies           About GeneDecksing



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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for SYTL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR018029 C2_membr_targeting
     IPR013083 Znf_RING/FYVE/PHD
     IPR000008 C2_Ca-dep
     IPR010911 Rab-bd_domain

    Graphical View of Domain Structure for InterPro Entry Q8IYJ3

    ProtoNet protein and cluster: Q8IYJ3

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 RabBD (Rab-binding) domain


    SYTL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL1_HUMAN, Q8IYJ3
    Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate.
    Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18266782
    GO:0008270zinc ion binding ----
    GO:0017137Rab GTPase binding IEA--
    GO:0042043neurexin family protein binding ISS--
         
    SYTL1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sytl1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  other  skeleton 

    SYTL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sytl1tm1Mitf for SYTL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYTL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYTL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYTL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYTL1 

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SYTL1 (NM_032872)
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                         Customized lentivirus expression plasmids for stable overexpression of SYTL1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYTL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL1
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SYTL1 (Q8IYJ33 ENSP000003164644) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145983, ENSP000002894734I2D: score=2 STRING: ENSP00000289473
    NCF2P198783, ENSP000003565054I2D: score=2 STRING: ENSP00000356505
    RAB27BO001943, ENSP000002620944I2D: score=1 STRING: ENSP00000262094
    RAB27AP511593, ENSP000003377614I2D: score=6 STRING: ENSP00000337761
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IDA18266782

    SYTL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYTL1

    1 HMDB Compound for SYTL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about SYTL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYTL1 gene (2 alternative transcripts): 
    NM_001193308.1  NM_032872.2  

    Unigene Cluster for SYTL1:

    Synaptotagmin-like 1
    Hs.469175  [show with all ESTs]
    Unigene Representative Sequence: AK074154
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318074(uc001bnv.2) ENST00000483926(uc001bnw.2) ENST00000473280
    ENST00000490170 ENST00000496001 ENST00000485269 ENST00000475199 ENST00000543823(uc009vsv.2)

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYTL1
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK027902.1 AK074154.1 AK096437.1 AK097172.1 AK126120.1 AK293038.1 AY037157.1 BC009224.2 
    BC015764.1 BC035725.1 

    11 DOTS entries:

    DT.310113  DT.100644757  DT.92426536  DT.97859499  DT.86840989  DT.91922055  DT.95257063  DT.95253533 
    DT.121430217  DT.121430238  DT.95228143 

    24/192 AceView cDNA sequences (see all 192):

    BM920625 AK096437 CR612838 AK097172 BF663585 AI972204 BM744880 BM805142 
    CR626119 CR604153 NM_032872 BQ953055 BQ706222 BM129773 CR595955 AI656111 
    BQ773533 AK027902 BC015764 BF061869 BM141958 BF061800 CR609080 BP334236 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
    SP1:                    -     -     -     -     -     -     -     -     -                 -                                         -                           
    SP2:                    -     -     -     -     -     -     -     -     -                 -                                                                     
    SP3:                          -     -     -     -     -     -     -     -                 -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -           -     -     -                                                               

    ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
    SP1:                                                  -                     
    SP2:                                                  -                     
    SP3:                                                  -                     
    SP4:                                                  -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for SYTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYTL1 expression in normal human tissues (normalized intensities)      SYTL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCTGGC
    SYTL1 Expression
    About this image


    SYTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Thymus (Hematopoietic System)

    See SYTL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYTL1

    SOURCE GeneReport for Unigene cluster: Hs.469175

    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum,
    occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYTL1 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl11 , 5 synaptotagmin-like 11, 5 82.59(n)1
    82.65(a)1
      4 (66.25 cM)5
    2695891  NM_031393.21  NP_113570.21 
     1332530905 
    chicken
    (Gallus gallus)
    Aves SYTL11 synaptotagmin-like 1 63.9(n)
    57.61(a)
      771987  NM_001080889.1  NP_001074358.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYTL16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343464.1(249216-257611)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075803.12   -- 72.26(n)    BJ075803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-228a15.31 si:dkey-228a15.3 53.26(n)
    47.85(a)
      777759  XM_003200634.1  XP_003200682.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rph6
    Rabphilin
    13(a)
    1 → many
    X(10643108-10651699)
    worm
    (Caenorhabditis elegans)
    Secernentea rbf-16
    Rabphilin-1
    8(a)
    1 → many
    III(6675801-6703996)


    ENSEMBL Gene Tree for SYTL1 (if available)
    TreeFam Gene Tree for SYTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYTL1 gene
    SYTL42  SYTL52  SYTL32  SYTL22  
    8 SIMAP similar genes for SYTL1 using alignment to 3 protein entries:     SYTL1_HUMAN (see all proteins):
    CHR11SYT    SYTL2    SYTL5    SYTL3    SYTL4    SYT1
    SYT2    SYT5

    SYTL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 SNPs in SYTL1 are shown (see all 312)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875006411,2
    --27666484(+) GGGTGC/TATAAA 2 -- us2k10--------
    rs743501181,2
    F--27666488(+) GCATAA/CATGCA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1926338161,2
    --27666552(+) ACTTTA/GGGAGG 2 -- us2k10--------
    rs1842885351,2
    --27666784(+) AAAAAA/GGAAAA 2 -- us2k10--------
    rs1141692671,2
    C,F--27666881(+) TTAATT/CTGCAA 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs2021693751,2
    --27667011(+) TTTTC-/TTTTTC 2 -- us2k10--------
    rs120234091,2
    C,F,H--27667016(+) cttttT/Cttttt 2 -- us2k1 tfbs3 trp39Minor allele frequency- C:0.03NS NA WA CSA 461
    rs2006778851,2
    --27667016(+) CTTTT-/CTTTTT 2 -- us2k10--------
    rs1437277741,2
    C--27667072(+) TGGTGC/TGATCT 2 -- us2k10--------
    rs1923333281,2
    --27667122(+) CTCCTG/TCCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYTL1 (27668483 - 27680423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SYTL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516766CNV Loss19592680
    nsv870665CNV Loss21882294
    dgv204n71CNV Loss21882294
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608042    OMIM disorders: --

    2 diseases for SYTL1:    About MalaCards
    crohn's disease    prostatitis


    SYTL1 for disorders           About GeneDecksing


    Export disorders for SYTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYTL1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SYTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)1, 2 Holt O....Griffiths G.M. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. (PubMed id 12137562)1, 3 Catz S.D....Johnson J.L. (2002)
    5. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. (PubMed id 11278853)1, 2 McAdara Berkowitz J.K....Babior B.M. (2001)
    6. Synaptotagmin-like protein 1 interacts with the GTPas e-activating protein Rap1GAP2 and regulates dense granule secretion in platelet s. (PubMed id 19528539)1, 9 NeumA1ller O....Smolenski A.P. (2009)
    7. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PubMed id 16004602)1, 9 Johnson J.L....Catz S.D. (2005)
    8. Vesicular trafficking through cortical actin during ex ocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activ ating protein Gem-interacting protein. (PubMed id 22438581)1 Johnson J.L....Catz S.D. (2012)
    9. The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-g. (PubMed id 23082202)1 Zhang W....Koepp D.M. (2012)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84958 HGNC: 15584 AceView: SYTL1 Ensembl:ENSG00000142765 euGenes: HUgn84958
    ECgene: SYTL1 H-InvDB: SYTL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYTL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYTL1 gene:
    Search GeneIP for patents involving SYTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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