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Aliases for SYTL1 Gene

Aliases for SYTL1 Gene

  • Synaptotagmin Like 1 2 3 5
  • Synaptotagmin-Like 1 2 3
  • Exophilin-7 3 4
  • SLP1 3 4
  • NADPH Oxidase-Related, C2 Domain-Containing Protein 3
  • Protein JFC1 4
  • JFC1 3

External Ids for SYTL1 Gene

Previous GeneCards Identifiers for SYTL1 Gene

  • GC01P027274
  • GC01P027541
  • GC01P027668
  • GC01P025924

Summaries for SYTL1 Gene

GeneCards Summary for SYTL1 Gene

SYTL1 (Synaptotagmin Like 1) is a Protein Coding gene. Among its related pathways are Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYTL3.

UniProtKB/Swiss-Prot for SYTL1 Gene

  • May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Wiki entry for SYTL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL1 Gene

Genomics for SYTL1 Gene

Regulatory Elements for SYTL1 Gene

Promoters for SYTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYTL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYTL1 Gene

Chromosome:
1
Start:
27,341,992 bp from pter
End:
27,353,937 bp from pter
Size:
11,946 bases
Orientation:
Plus strand

Genomic View for SYTL1 Gene

Genes around SYTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL1 Gene

Proteins for SYTL1 Gene

  • Protein details for SYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ3-SYTL1_HUMAN
    Recommended name:
    Synaptotagmin-like protein 1
    Protein Accession:
    Q8IYJ3
    Secondary Accessions:
    • Q5SSC9
    • Q96BB6
    • Q96GU6
    • Q96S89
    • Q96SI0

    Protein attributes for SYTL1 Gene

    Size:
    562 amino acids
    Molecular mass:
    61857 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Binds NCF2.
    SequenceCaution:
    • Sequence=AAH15764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL1 Gene

Proteomics data for SYTL1 Gene at MOPED

Post-translational modifications for SYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYTL1 Gene

Antibody Products

No data available for DME Specific Peptides for SYTL1 Gene

Domains & Families for SYTL1 Gene

Gene Families for SYTL1 Gene

Protein Domains for SYTL1 Gene

Suggested Antigen Peptide Sequences for SYTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYJ3

UniProtKB/Swiss-Prot:

SYTL1_HUMAN :
  • Contains 2 C2 domains.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL1: view

Function for SYTL1 Gene

Molecular function for SYTL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0042043 neurexin family protein binding ISS --
genes like me logo Genes that share ontologies with SYTL1: view
genes like me logo Genes that share phenotypes with SYTL1: view

Animal Models for SYTL1 Gene

MGI Knock Outs for SYTL1:

Animal Model Products

CRISPR Products

miRNA for SYTL1 Gene

miRTarBase miRNAs that target SYTL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYTL1 Gene

Localization for SYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL1 Gene COMPARTMENTS Subcellular localization image for SYTL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0019897 extrinsic component of plasma membrane ISS --
genes like me logo Genes that share ontologies with SYTL1: view

Pathways & Interactions for SYTL1 Gene

genes like me logo Genes that share pathways with SYTL1: view

Pathways by source for SYTL1 Gene

Gene Ontology (GO) - Biological Process for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYTL1: view

No data available for SIGNOR curated interactions for SYTL1 Gene

Drugs & Compounds for SYTL1 Gene

(1) Drugs for SYTL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SYTL1: view

Transcripts for SYTL1 Gene

Unigene Clusters for SYTL1 Gene

Synaptotagmin-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14: - - -
SP15:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SYTL1 Gene

GeneLoc Exon Structure for
SYTL1
ECgene alternative splicing isoforms for
SYTL1

Expression for SYTL1 Gene

mRNA expression in normal human tissues for SYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL1 Gene

This gene is overexpressed in Whole Blood (x7.6), Esophagus - Mucosa (x5.4), Pancreas (x4.6), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for SYTL1 Gene

This gene is overexpressed in Cervix (21.8) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYTL1 Gene



SOURCE GeneReport for Unigene cluster for SYTL1 Gene Hs.469175

mRNA Expression by UniProt/SwissProt for SYTL1 Gene

Q8IYJ3-SYTL1_HUMAN
Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
genes like me logo Genes that share expression patterns with SYTL1: view

Protein tissue co-expression partners for SYTL1 Gene

Primer Products

In Situ Assay Products

Orthologs for SYTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL1 35
  • 99.41 (n)
  • 98.75 (a)
SYTL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYTL1 36
  • 78 (a)
OneToOne
SYTL1 35
  • 86.95 (n)
  • 83.1 (a)
dog
(Canis familiaris)
Mammalia SYTL1 35
  • 88.35 (n)
  • 86.63 (a)
SYTL1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sytl1 16
Sytl1 36
  • 82 (a)
OneToOne
Sytl1 35
  • 82.59 (n)
  • 82.65 (a)
oppossum
(Monodelphis domestica)
Mammalia SYTL1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sytl1 35
  • 81.68 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves SYTL1 35
  • 63.71 (n)
  • 57.42 (a)
-- 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SYTL1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl1 35
  • 52.45 (n)
  • 50.2 (a)
zebrafish
(Danio rerio)
Actinopterygii SYTL1 36
  • 42 (a)
OneToOne
LOC565707 35
  • 51.62 (n)
  • 47.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta btsz 36
  • 5 (a)
OneToMany
Species with no ortholog for SYTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL1 Gene

ENSEMBL:
Gene Tree for SYTL1 (if available)
TreeFam:
Gene Tree for SYTL1 (if available)

Paralogs for SYTL1 Gene

Paralogs for SYTL1 Gene

(8) SIMAP similar genes for SYTL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYTL1: view

Variants for SYTL1 Gene

Sequence variations from dbSNP and Humsavar for SYTL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8533 -- 27,353,801(-) ACCCA(C/T)TCGCA nc-transcript-variant, reference, synonymous-codon
rs10335 -- 27,353,865(-) GAGAG(A/G)GGCTT nc-transcript-variant, utr-variant-3-prime
rs4316383 -- 27,352,796(-) aaaaa(A/T)TAATA intron-variant
rs4246507 -- 27,348,732(-) TTTTT(A/T)AATTT intron-variant
rs4246508 -- 27,348,826(-) ACCTC(C/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL1 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294

Variation tolerance for SYTL1 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.42; 95.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL1 Gene

HapMap Linkage Disequilibrium report
SYTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL1 Gene

Disorders for SYTL1 Gene

Relevant External Links for SYTL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL1

No disorders were found for SYTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL1 Gene

Publications for SYTL1 Gene

  1. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PMID: 18266782) Holt O. … Griffiths G.M. (Traffic 2008) 3 4 67
  2. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. (PMID: 19528539) NeumA1ller O. … Smolenski A.P. (Blood 2009) 3 23
  3. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PMID: 16004602) Johnson J.L. … Catz S.D. (Biochem. J. 2005) 3 23
  4. JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. (PMID: 12137562) Catz S.D. … Johnson J.L. (Biochem. J. 2002) 2 3
  5. Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. (PMID: 24285265) Meyer M. … Jaspers I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2014) 3

Products for SYTL1 Gene

Sources for SYTL1 Gene

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