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Aliases for SYTL1 Gene

Aliases for SYTL1 Gene

  • Synaptotagmin Like 1 2 3 5
  • Exophilin-7 3 4
  • SLP1 3 4
  • NADPH Oxidase-Related, C2 Domain-Containing Protein 3
  • Synaptotagmin-Like Protein 1 3
  • Synaptotagmin-Like 1 2
  • Protein JFC1 4
  • JFC1 3

External Ids for SYTL1 Gene

Previous GeneCards Identifiers for SYTL1 Gene

  • GC01P027274
  • GC01P027541
  • GC01P027668
  • GC01P025924

Summaries for SYTL1 Gene

GeneCards Summary for SYTL1 Gene

SYTL1 (Synaptotagmin Like 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYTL2.

UniProtKB/Swiss-Prot for SYTL1 Gene

  • May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Wiki entry for SYTL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL1 Gene

Genomics for SYTL1 Gene

Regulatory Elements for SYTL1 Gene

Enhancers for SYTL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F027516 1 FANTOM5 ENCODE 11.9 +181.8 181822 13.7 HDGF PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 ACTG1P20 LOC105376890 CD164L2 WASF2 SYTL1 NPM1P39 PHACTR4 ENSG00000231344 MAP3K6 FAM76A
GH01F027290 0.2 ENCODE 11.1 -50.4 -50443 2.8 BCOR HDGF CTCF ZMYM3 RAD21 ZFHX2 POLR2A NR2F6 ZSCAN29 EGR2 TMEM222 WDTC1 ACTG1P20 RNU6-48P LOC105376890 ENSG00000231207 GPR3 SYTL1 FAM46B ENSG00000243659
GH01F027339 0.9 ENCODE 10.4 0.0 -18 4.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ENSG00000243659 ENSG00000231207 GPR3 TMEM222 SYTL1 WDTC1 RNU6-48P
GH01F027369 0.2 ENCODE 8.4 +27.8 27833 1.4 CTCF TAL1 IKZF1 SMC3 ZNF24 RAD21 SPI1 TMEM222 SYTL1 MAP3K6 FCN3
GH01F027321 0.2 ENCODE 5.7 -19.3 -19341 2.2 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 NPM1P39 ENSG00000231344 LOC101928728 RPL17P9 ACTG1P20 HMGN2 LOC101928324 AHDC1 SYTL1 TMEM222
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SYTL1 on UCSC Golden Path with GeneCards custom track

Promoters for SYTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000161828 808 2001 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1

Genomic Location for SYTL1 Gene

Chromosome:
1
Start:
27,341,992 bp from pter
End:
27,353,937 bp from pter
Size:
11,946 bases
Orientation:
Plus strand

Genomic View for SYTL1 Gene

Genes around SYTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL1 Gene

Proteins for SYTL1 Gene

  • Protein details for SYTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ3-SYTL1_HUMAN
    Recommended name:
    Synaptotagmin-like protein 1
    Protein Accession:
    Q8IYJ3
    Secondary Accessions:
    • Q5SSC9
    • Q96BB6
    • Q96GU6
    • Q96S89
    • Q96SI0

    Protein attributes for SYTL1 Gene

    Size:
    562 amino acids
    Molecular mass:
    61857 Da
    Quaternary structure:
    • Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Binds NCF2.
    SequenceCaution:
    • Sequence=AAH15764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYTL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL1 Gene

Post-translational modifications for SYTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYTL1 Gene

Domains & Families for SYTL1 Gene

Gene Families for SYTL1 Gene

Protein Domains for SYTL1 Gene

Suggested Antigen Peptide Sequences for SYTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYJ3

UniProtKB/Swiss-Prot:

SYTL1_HUMAN :
  • Contains 2 C2 domains.
Domain:
  • Contains 2 C2 domains.
  • Contains 1 RabBD (Rab-binding) domain.
genes like me logo Genes that share domains with SYTL1: view

Function for SYTL1 Gene

Molecular function for SYTL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 18266782
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYTL1: view
genes like me logo Genes that share phenotypes with SYTL1: view

Animal Models for SYTL1 Gene

MGI Knock Outs for SYTL1:

Animal Model Products

miRNA for SYTL1 Gene

miRTarBase miRNAs that target SYTL1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYTL1 Gene

Localization for SYTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYTL1 Gene COMPARTMENTS Subcellular localization image for SYTL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
nucleus 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,IDA 18266782
GO:0016020 membrane IEA --
GO:0019897 extrinsic component of plasma membrane ISS --
GO:0042470 melanosome ISS --
genes like me logo Genes that share ontologies with SYTL1: view

Pathways & Interactions for SYTL1 Gene

genes like me logo Genes that share pathways with SYTL1: view

Pathways by source for SYTL1 Gene

2 Reactome pathways for SYTL1 Gene

Gene Ontology (GO) - Biological Process for SYTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IDA 18266782
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYTL1: view

No data available for SIGNOR curated interactions for SYTL1 Gene

Drugs & Compounds for SYTL1 Gene

(1) Drugs for SYTL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SYTL1: view

Transcripts for SYTL1 Gene

Unigene Clusters for SYTL1 Gene

Synaptotagmin-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - - - -
SP14: - - -
SP15:

ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SYTL1 Gene

GeneLoc Exon Structure for
SYTL1
ECgene alternative splicing isoforms for
SYTL1

Expression for SYTL1 Gene

mRNA expression in normal human tissues for SYTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL1 Gene

This gene is overexpressed in Whole Blood (x7.6), Esophagus - Mucosa (x5.4), Pancreas (x4.6), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for SYTL1 Gene

This gene is overexpressed in Cervix (21.8) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYTL1 Gene



Protein tissue co-expression partners for SYTL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYTL1 Gene:

SYTL1

SOURCE GeneReport for Unigene cluster for SYTL1 Gene:

Hs.469175

mRNA Expression by UniProt/SwissProt for SYTL1 Gene:

Q8IYJ3-SYTL1_HUMAN
Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
genes like me logo Genes that share expression patterns with SYTL1: view

Primer Products

Orthologs for SYTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL1 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia SYTL1 34 35
  • 88.35 (n)
cow
(Bos Taurus)
Mammalia SYTL1 34 35
  • 86.95 (n)
mouse
(Mus musculus)
Mammalia Sytl1 34 16 35
  • 82.59 (n)
rat
(Rattus norvegicus)
Mammalia Sytl1 34
  • 81.68 (n)
oppossum
(Monodelphis domestica)
Mammalia SYTL1 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SYTL1 34
  • 63.71 (n)
-- 35
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SYTL1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl1 34
  • 52.45 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC565707 34
  • 51.62 (n)
SYTL1 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta btsz 35
  • 5 (a)
OneToMany
Species where no ortholog for SYTL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL1 Gene

ENSEMBL:
Gene Tree for SYTL1 (if available)
TreeFam:
Gene Tree for SYTL1 (if available)

Paralogs for SYTL1 Gene

Paralogs for SYTL1 Gene

(8) SIMAP similar genes for SYTL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYTL1: view

Variants for SYTL1 Gene

Sequence variations from dbSNP and Humsavar for SYTL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10335 -- 27,353,865(-) GAGAG(A/G)GGCTT nc-transcript-variant, utr-variant-3-prime
rs111554084 -- 27,347,741(+) CCAGG(C/G)CCTCT intron-variant
rs111621858 -- 27,343,660(+) TTCCC(-/AT)GTGTG intron-variant
rs111967244 -- 27,341,021(+) ACTAT(A/G)TTAGC upstream-variant-2KB
rs112073592 -- 27,347,472(+) ACAGG(A/G)GACTG nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SYTL1 Gene

Variant ID Type Subtype PubMed ID
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for SYTL1 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.42; 95.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL1 Gene

Disorders for SYTL1 Gene

Relevant External Links for SYTL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL1

No disorders were found for SYTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYTL1 Gene

Publications for SYTL1 Gene

  1. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. (PMID: 19528539) NeumA1ller O. … Smolenski A.P. (Blood 2009) 3 22 64
  2. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PMID: 18266782) Holt O. … Griffiths G.M. (Traffic 2008) 3 4 64
  3. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PMID: 16004602) Johnson J.L. … Catz S.D. (Biochem. J. 2005) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SYTL1 Gene

Sources for SYTL1 Gene

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