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SYTL1 Gene

protein-coding   GIFtS: 52
GCID: GC01P027668

Synaptotagmin-Like 1

  Search for SYTL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin-Like 11 2     NADPH Oxidase-Related, C2 Domain-Containing Protein2
SLP12 3 5     Synaptotagmin-Like Protein 12
JFC12 5     Exophilin-73
exophilin-72     Protein JFC13

External Ids:    HGNC: 155841   Entrez Gene: 849582   Ensembl: ENSG000001427657   OMIM: 6080425   UniProtKB: Q8IYJ33   

Export aliases for SYTL1 gene to outside databases

Previous GC identifers: GC01P027274 GC01P027352 GC01P027541 GC01P025924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SYTL1 Gene:
SYTL1 (synaptotagmin-like 1) is a protein-coding gene. GO annotations related to this gene include neurexin family protein binding and Rab GTPase binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate.
Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By
similarity)

Gene Wiki entry for SYTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYTL1 gene promoter:
         USF1   AML1a   Olf-1   POU3F2   YY1   USF-1   IRF-7A   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL1 promoter sequence
   Search Chromatin IP Primers for SYTL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

SYTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027668:  view genomic region     (about GC identifiers)

Start:
27,668,483 bp from pter      End:
27,680,423 bp from pter
Size:
11,941 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 1  
Size: 562 amino acids; 61857 Da
Subunit: Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By
similarity). Binds NCF2
Sequence caution: Sequence=AAH15764.1; Type=Erroneous initiation;
Secondary accessions: Q5SSC9 Q96BB6 Q96GU6 Q96S89 Q96SI0
Alternative splicing: 2 isoforms:  Q8IYJ3-1   Q8IYJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL1: NX_Q8IYJ3

Explore proteomics data for SYTL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180237.1  NP_116261.1  

    ENSEMBL proteins: 
     ENSP00000316464   ENSP00000420110   ENSP00000440704  

    SYTL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SYTL1

     
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    LSBio Antibodies in human, mouse, rat for SYTL1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028378 Sytl1
     IPR013083 Znf_RING/FYVE/PHD
     IPR000008 C2_dom
     IPR010911 Znf_FYVE-typ

    Graphical View of Domain Structure for InterPro Entry Q8IYJ3

    ProtoNet protein and cluster: Q8IYJ3

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 RabBD (Rab-binding) domain


    Find genes that share domains with SYTL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL1_HUMAN, Q8IYJ3
    Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate.
    Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18266782
    GO:0017137Rab GTPase binding IEA--
    GO:0042043neurexin family protein binding ISS--
         
    Find genes that share ontologies with SYTL1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sytl1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  other  skeleton 

    Find genes that share phenotypes with SYTL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SYTL1: Sytl1tm1Tiz Sytl1tm1Mitf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYTL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYTL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYTL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYTL1

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    miRTarBase miRNAs that target SYTL1:
    hsa-mir-335-5p (MIRT018489)

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYTL1_HUMAN, Q8IYJ3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane
    protein tightly bound to the cytoplasmic side of cellular membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA18266782
    GO:0016020membrane ----
    GO:0019897extrinsic component of plasma membrane ISS--
    GO:0042470melanosome ISS--

    Find genes that share ontologies with SYTL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYTL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    1 BioSystems Pathway for SYTL1
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYTL1
    Interactions:

        GeneGlobe Interaction Network for SYTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SYTL1 (Q8IYJ33 ENSP000003164644) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145983, ENSP000002894734I2D: score=2 STRING: ENSP00000289473
    NCF2P198783, ENSP000003565054I2D: score=2 STRING: ENSP00000356505
    RAB27BO001943, ENSP000002620944I2D: score=1 STRING: ENSP00000262094
    RAB27AP511593, ENSP000003377614I2D: score=6 STRING: ENSP00000337761
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IDA18266782

    Find genes that share ontologies with SYTL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYTL1

    1 HMDB Compound for SYTL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYTL1 gene (2 alternative transcripts): 
    NM_001193308.1  NM_032872.2  

    Unigene Cluster for SYTL1:

    Synaptotagmin-like 1
    Hs.469175  [show with all ESTs]
    Unigene Representative Sequence: AK074154
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318074(uc001bnv.2) ENST00000483926(uc001bnw.2) ENST00000473280
    ENST00000490170 ENST00000496001 ENST00000485269 ENST00000475199 ENST00000543823(uc009vsv.2)

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    GenScript: all cDNA clones in your preferred vector (see all 2): SYTL1 (NM_032872)
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      QuantiTect SYBR Green Assays in human, mouse, rat SYTL1
      QuantiFast Probe-based Assays in human, mouse, rat SYTL1

    Additional mRNA sequence: 

    AK027902.1 AK074154.1 AK096437.1 AK097172.1 AK126120.1 AK293038.1 AY037157.1 BC009224.2 
    BC015764.1 BC035725.1 

    11 DOTS entries:

    DT.310113  DT.100644757  DT.92426536  DT.97859499  DT.86840989  DT.91922055  DT.95257063  DT.95253533 
    DT.121430217  DT.121430238  DT.95228143 

    Selected AceView cDNA sequences (see all 192):

    BM922835 BF061800 BP334236 BQ773533 AI656111 AK097172 CR590979 BQ953055 
    BM141958 BQ706222 BM920625 BM805142 CR612838 BM781732 AI972204 BM742237 
    AK027902 BM744880 BC035725 NM_032872 BM129773 CR609080 BF663585 BI908237 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
    SP1:                    -     -     -     -     -     -     -     -     -                 -                                         -                           
    SP2:                    -     -     -     -     -     -     -     -     -                 -                                                                     
    SP3:                          -     -     -     -     -     -     -     -                 -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -           -     -     -                                                               

    ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
    SP1:                                                  -                     
    SP2:                                                  -                     
    SP3:                                                  -                     
    SP4:                                                  -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for SYTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCTGGC
    SYTL1 Expression
    About this image


    SYTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Thymus (Hematopoietic System)
    SYTL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYTL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469175

    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum,
    occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYTL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sytl11 , 5 synaptotagmin-like 11, 5 82.59(n)1
    82.65(a)1
      4 (66.25 cM)5
    2695891  NM_031393.21  NP_113570.21 
     1332530905 
    chicken
    (Gallus gallus)
    Aves SYTL11 synaptotagmin-like 1 63.71(n)
    57.42(a)
      771987  NM_001080889.1  NP_001074358.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYTL16
    synaptotagmin-like 1
    58(a)
    1 ↔ 1
    GL343464.1(249216-257611)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075803.12   -- 72.26(n)    BJ075803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5657071 uncharacterized LOC565707 51.62(n)
    47.98(a)
      565707  XM_688977.5  XP_694069.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta btsz6
    bitesize
    5(a)
    1 → many
    3R(10629814-10679626)


    ENSEMBL Gene Tree for SYTL1 (if available)
    TreeFam Gene Tree for SYTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYTL1 gene
    SYTL42  SYTL52  DOC2B2  DOC2A2  SYTL32  RPH3A2  SYTL22  
    8 SIMAP similar genes for SYTL1 using alignment to 3 protein entries:     SYTL1_HUMAN (see all proteins):
    CHR11SYT    SYTL2    SYTL5    SYTL3    SYTL4    SYT1
    SYT2    SYT5

    Find genes that share paralogs with SYTL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYTL1 (see all 312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875006411,2
    --27666484(+) GGGTGC/TATAAA 2 -- us2k10--------
    rs743501181,2
    F--27666488(+) GCATAA/CATGCA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1926338161,2
    --27666552(+) ACTTTA/GGGAGG 2 -- us2k10--------
    rs1842885351,2
    --27666784(+) AAAAAA/GGAAAA 2 -- us2k10--------
    rs1141692671,2
    C,F--27666881(+) TTAATT/CTGCAA 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs2021693751,2
    --27667011(+) TTTTC-/TTTTTC 2 -- us2k10--------
    rs120234091,2
    C,F,H--27667016(+) cttttT/Cttttt 2 -- us2k1 tfbs3 trp39Minor allele frequency- C:0.03NS NA WA CSA 461
    rs2006778851,2
    --27667016(+) CTTTT-/CTTTTT 2 -- us2k10--------
    rs1437277741,2
    C--27667072(+) TGGTGC/TGATCT 2 -- us2k10--------
    rs1923333281,2
    --27667122(+) CTCCTG/TCCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYTL1 (27668483 - 27680423 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SYTL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516766CNV Loss19592680
    nsv870665CNV Loss21882294
    dgv204n71CNV Loss21882294
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SYTL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYTL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608042    OMIM disorders: --


    Find genes that share disorders with SYTL1           About GenesLikeMe


    Export disorders for SYTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYTL1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SYTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)1, 2 Holt O.... Griffiths G.M. (Traffic 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. (PubMed id 12137562)1, 3 Catz S.D....Johnson J.L. (Biochem. J. 2002)
    5. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. (PubMed id 11278853)1, 2 McAdara Berkowitz J.K....Babior B.M. (J. Biol. Chem. 2001)
    6. Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. (PubMed id 19528539)1, 9 NeumA1ller O....Smolenski A.P. (Blood 2009)
    7. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PubMed id 16004602)1, 9 Johnson J.L....Catz S.D. (Biochem. J. 2005)
    8. Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers. (PubMed id 24285265)1 Meyer M....Jaspers I. (Am. J. Physiol. Lung Cell Mol. Physiol. 2014)
    9. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. (PubMed id 22438581)1 Johnson J.L....Catz S.D. (Mol. Biol. Cell 2012)
    10. The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-I^. (PubMed id 23082202)1 Zhang W....Koepp D.M. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84958 HGNC: 15584 AceView: SYTL1 Ensembl:ENSG00000142765 euGenes: HUgn84958
    ECgene: SYTL1 H-InvDB: SYTL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYTL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SYTL1 gene:
    Search GeneIP for patents involving SYTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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