Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYTL1 Gene

protein-coding   GIFtS: 51
GCID: GC01P027668

synaptotagmin-like 1

 Explore 4 diseases affiliated with
SYTL1 via our new
 Human Malady Compendium 
Biological research products
for SYTL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Synaptotagmin-Like 11 2     NADPH Oxidase-Related, C2 Domain-Containing Protein2
SLP11 2 3 5     Synaptotagmin-Like Protein 12
JFC11 2 5     Exophilin-73
Exophilin-73     Protein JFC13
FLJ149961     

External Ids:    HGNC: 155841   Entrez Gene: 849582   Ensembl: ENSG000001427657   OMIM: 6080425   UniProtKB: Q8IYJ33   

Export aliases for SYTL1 gene to outside databases

Previous GC identifers: GC01P027274 GC01P027352 GC01P027541 GC01P025924


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts
as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity)

Gene Wiki entry for SYTL1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYTL1 gene promoter:
         USF1   AML1a   Olf-1   POU3F2   YY1   USF-1   IRF-7A   ARP-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

SYTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYTL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P027668:  view genomic region     (about GC identifiers)

Start:
27,668,483 bp from pter      End:
27,680,423 bp from pter
Size:
11,941 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3 (See protein sequence)
Recommended Name: Synaptotagmin-like protein 1  
Size: 562 amino acids; 61857 Da
Subunit: Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity).
Binds NCF2
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein
tightly bound to the cytoplasmic side of cellular membranes
Sequence caution: Sequence=AAH15764.1; Type=Erroneous initiation;
Secondary accessions: Q5SSC9 Q96BB6 Q96GU6 Q96S89 Q96SI0
Alternative splicing: 2 isoforms:  Q8IYJ3-1   Q8IYJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYTL1: NX_Q8IYJ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IYJ3

  • SYTL1 Protein expression data from MOPED and PaxDb:    About this image 
    SYTL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180237.1  NP_116261.1  

    ENSEMBL proteins: 
     ENSP00000316464   ENSP00000433671   ENSP00000420110   ENSP00000432815   ENSP00000417187  
     ENSP00000420349   ENSP00000440704  

    Human Recombinant Protein Products for SYTL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SYTL1
    OriGene Custom Protein Services for SYTL1 
    GenScript Custom Purified and Recombinant Proteins Services for SYTL1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SYTL1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane IDA18266782
    GO:0019897extrinsic to plasma membrane ISS--
    GO:0042470melanosome ISS--

    SYTL1 for ontologies           About GeneDecksing



    SYTL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SYTL1 
    GenScript Custom Superior Antibodies Services for SYTL1
    Novus Biologicals SYTL1 Antibodies
    Abcam antibodies for SYTL1 
    Uscn Antibodies for SYTL1
    Search ThermoFisher Antibodies for SYTL1

    Assay Products for SYTL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYTL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SYTL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SYTL1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR018029 C2_membr_targeting
     IPR013083 Znf_RING/FYVE/PHD
     IPR000008 C2_Ca-dep
     IPR010911 Rab-bd_domain

    Graphical View of Domain Structure for InterPro Entry Q8IYJ3

    ProtoNet protein and cluster: Q8IYJ3

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Similarity: Contains 2 C2 domains
    Similarity: Contains 1 RabBD (Rab-binding) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYTL1_HUMAN, Q8IYJ3
    Function: May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts
    as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18266782
    GO:0017137Rab GTPase binding IEA--
    GO:0042043neurexin family protein binding ISS--
         
    SYTL1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sytl1):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  other  skeleton 

    SYTL1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Sytl1tm1Mitf for SYTL1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYTL1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SYTL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYTL1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL1 (see all 7)
    OriGene shRNA RFP: SYTL1
    OriGene siRNA: SYTL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SYTL1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYTL1
    Sirion Biotech Customized adenovirus for overexpression of SYTL1 
    Sirion Biotech Customized adenovirus for potent knockdown of SYTL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SYTL1 (NM_032872)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYTL1
    Search LifeMap BioReagents cell lines for SYTL1
    Sirion Biotech Customized stable knockdown cell line services for SYTL1 
    Sirion Biotech Customized inducible knockdown cell line services for SYTL1
    Sirion Biotech Customized stable overexpressing cell line services for SYTL1
    Sirion Biotech Customized inducible overexpressing cell line services for SYTL1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deregulation of Rab and Rab Effector Genes in Bladder Cancer
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer1.00


    1 BioSystems Pathway for SYTL1 
        Deregulation of Rab and Rab Effector Genes in Bladder Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for SYTL1 (Q8IYJ33 ENSP000003164644) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCF1P145983, ENSP000002894734I2D: score=2 STRING: ENSP00000289473
    NCF2P198783, ENSP000003565054I2D: score=2 STRING: ENSP00000356505
    RAB27BO001943, ENSP000002620944I2D: score=1 STRING: ENSP00000262094
    RAB27AP511593, ENSP000003377614I2D: score=6 STRING: ENSP00000337761
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006887exocytosis IDA18266782

    SYTL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYTL1

    1 HMDB Compound for SYTL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about SYTL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYTL1 gene (2 alternative transcripts): 
    NM_001193308.1  NM_032872.2  

    Unigene Cluster for SYTL1:

    Synaptotagmin-like 1
    Hs.469175  [show with all ESTs]
    Unigene Representative Sequence: AK074154
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318074(uc001bnv.2) ENST00000483926(uc001bnw.2) ENST00000473280
    ENST00000494895(uc001bnx.2) ENST00000490170 ENST00000496001 ENST00000485269
    ENST00000475199 ENST00000543823(uc009vsv.2)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SYTL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYTL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYTL1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL1 (see all 7)
    OriGene shRNA RFP: SYTL1
    OriGene siRNA: SYTL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SYTL1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SYTL1 (NM_032872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYTL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL1

    Additional cDNA sequence: 

    AK027902.1 AK074154.1 AK096437.1 AK097172.1 AK126120.1 AK293038.1 AY037157.1 BC009224.2 
    BC015764.1 BC035725.1 

    11 DOTS entries:

    DT.310113  DT.100644757  DT.92426536  DT.97859499  DT.86840989  DT.91922055  DT.95257063  DT.95253533 
    DT.121430217  DT.121430238  DT.95228143 

    24/192 AceView cDNA sequences (see all 192):

    BM922835 BF061800 AK027902 AI973222 BM920625 BM129773 AK097172 BQ953055 
    BI908237 NM_032872 CR612838 BM742237 BM805142 AK096437 BM781724 BM781732 
    BP334236 CR604153 AI656111 BQ706222 BF663585 BM141958 AI972204 CR626119 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SYTL1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a ·
    SP1:                    -     -     -     -     -     -     -     -     -                 -                                         -                           
    SP2:                    -     -     -     -     -     -     -     -     -                 -                                                                     
    SP3:                          -     -     -     -     -     -     -     -                 -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -     -     -     -           -     -     -                                                               

    ExUns: 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b
    SP1:                                                  -                     
    SP2:                                                  -                     
    SP3:                                                  -                     
    SP4:                                                  -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for SYTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCCCTGGC
    SYTL1 Expression
    About this image
    See SYTL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYTL1

    SOURCE GeneReport for Unigene cluster: Hs.469175

    UniProtKB/Swiss-Prot: SYTL1_HUMAN, Q8IYJ3
    Tissue specificity: Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum,
    occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL)

        SABiosciences Custom PCR Arrays for SYTL1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYTL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYTL1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SYTL11 synaptotagmin-like 1 63.9(n)
    57.61(a)
      771987  NM_001080889.1  NP_001074358.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYTL16
    --
    58(a)
    1 ↔ 1
    GL343464.1(249268-255346)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075803.12   -- 72.26(n)    BJ075803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-228a15.31 si:dkey-228a15.3 53.26(n)
    47.85(a)
      777759  XM_003200634.1  XP_003200682.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta btsz6
    bitesize
    4(a)
    1 → many
    3R(10629814-10679626)
    worm
    (Caenorhabditis elegans)
    Secernentea snt-66
    SyNapTotagmin family member (snt-6)
    18(a)
    possible ortholog
    II(745469-750171)


    ENSEMBL Gene Tree for SYTL1 (if available)
    TreeFam Gene Tree for SYTL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYTL1 gene
    SYTL42  DOC2B2  SYTL52  DOC2A2  SYTL32  RPH3A2  SYTL22  
    9 SIMAP similar genes for SYTL1 using alignment to 7 protein entries:     SYTL1_HUMAN (see all proteins):
    FLJ00227    CHR11SYT    SYTL2    SYTL5    SYTL3    SYTL4
    SYT1    SYT2    SYT5

    SYTL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/228 NCBI SNPs in SYTL1 are shown (see all 228    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875006411,2
    --27666484(+) GGGTGC/TATAAA 2 -- us2k10--------
    rs743501181,2
    --27666488(+) GCATAA/CATGCA 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1926338161,2
    --27666552(+) ACTTTA/GGGAGG 2 -- us2k10--------
    rs1842885351,2
    --27666784(+) AAAAAA/GGAAAA 2 -- us2k10--------
    rs1141692671,2
    C,F--27666881(+) TTAATT/CTGCAA 2 -- us2k11Minor allele frequency- C:0.05WA 118
    rs2021693751,2
    --27667011(+) TTTTC-/TTTTTC 2 -- us2k10--------
    rs120234091,2
    C,F,H--27667016(+) CTTTTT/CTTTTT 2 -- us2k1 tfbs3 trp39Minor allele frequency- C:0.03NS NA WA CSA 461
    rs2006778851,2
    --27667016(+) CTTTT-/CTTTTT 2 -- us2k10--------
    rs1437277741,2
    --27667072(+) TGGTGC/TGATCT 2 -- us2k10--------
    rs1923333281,2
    --27667122(+) CTCCTG/TCCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYTL1 (27668483 - 27680423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SYTL1
         1 CNV: 48306

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYTL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYTL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SYTL1 for disorders           About GeneDecksing

    OMIM gene information: 608042    OMIM disorders: --

    4 diseases for SYTL1:    About MalaCards
    crohn's disease    prostate carcinoma    prostatitis    carcinoma


    Export disorders for SYTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYTL1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SYTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. (PubMed id 18266782)1, 2 Holt O....Griffiths G.M. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. (PubMed id 12137562)1, 3 Catz S.D....Johnson J.L. (2002)
    5. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. (PubMed id 11278853)1, 2 McAdara Berkowitz J.K....Babior B.M. (2001)
    6. Synaptotagmin-like protein 1 interacts with the GTPas e-activating protein Rap1GAP2 and regulates dense granule secretion in platelet s. (PubMed id 19528539)1, 9 NeumA1ller O....Smolenski A.P. (2009)
    7. The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. (PubMed id 16004602)1, 9 Johnson J.L....Catz S.D. (2005)
    8. Vesicular trafficking through cortical actin during ex ocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activ ating protein Gem-interacting protein. (PubMed id 22438581)1 Johnson J.L....Catz S.D. (2012)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. (PubMed id 17200145)1 Schmid M....Wehkamp J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84958 HGNC: 15584 AceView: SYTL1 Ensembl:ENSG00000142765 euGenes: HUgn84958
    ECgene: SYTL1 H-InvDB: SYTL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYTL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYTL1 gene:
    Search GeneIP for patents involving SYTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SYTL1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYTL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYTL1  
     OriGene Protein Over-expression Lysate for SYTL1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SYTL1   OriGene 3'-UTR Clone for SYTL1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYTL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYTL1   OriGene Custom Protein Services for SYTL1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYTL1
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYTL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYTL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYTL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYTL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYTL1
     GenScript Custom Purified and Recombinant Proteins Services for SYTL1 GenScript cDNA clones with any tag delivered in your preferred vector for SYTL1
     GenScript Custom Assay Services for SYTL1 GenScript Custom Superior Antibodies Services for SYTL1
     GenScript Custom overexpressing Cell Line Services for SYTL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SYTL1 promoter
     Search Chromatin IP Primers for SYTL1
     RT2 qPCR Primer Assay in human, mouse, rat SYTL1
     GNC Network for SYTL1
     SABiosciences Custom PCR Arrays for SYTL1
     Search Tocris compounds for SYTL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SYTL1 antibodies
     Antibodies for SYTL1
     See all of Abcam's Antibodies, Kits and Proteins for SYTL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SYTL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SYTL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYTL1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SYTL1
     SwitchGear Promoter luciferase reporter plasmids for SYTL1
     Search ThermoFisher Antibodies for SYTL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYTL1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYTL1
    Sirion Biotech Customized:
     stable knockdown cell line services for SYTL1
     inducible knockdown cell line services for SYTL1
     design and validation of potent shRNA sequences against SYTL1
     adenovirus for potent knockdown of SYTL1
     adenovirus for overexpression of SYTL1
     stable overexpressing cell line services for SYTL1
     inducible overexpressing cell line services for SYTL1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYTL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4