SYT9 Gene
protein-coding GIFtS: 50
GCID: GC11P007273
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synaptotagmin IX
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Aliases for SYT9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Synaptotagmin IX1 2 3 | | Synaptotagmin-91 | | SytIX3 | | SytIX3 |
Export aliases for SYT9 gene to outside databasesPrevious GC identifers: GC00U906273 GC11P007229 GC11P006931 |
Summaries for SYT9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SYT9_HUMAN, Q86SS6Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid bindingto the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis Gene Wiki entry for SYT9
|
Genomic Views for SYT9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SYT9 gene promoter: TBP STAT1 STAT4 p300 MyoD STAT1alpha CREB TFIID deltaCREB Cart-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for SYT9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT9 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4SYT9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P007273: view genomic region
(about GC identifiers)
Start:
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7,260,099 bp from pter |
End:
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7,490,276 bp from pter |
Size:
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230,178 bases |
Orientation:
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plus strand |
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Proteins for SYT9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SYT9_HUMAN, Q86SS6 (See
protein sequence)Recommended Name: Synaptotagmin-9 Size: 491 amino acids; 56188 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein(By similarity)Explore the universe of human proteins at neXtProt for SYT9: NX_Q86SS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86SS6 SYT9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_783860.1 ENSEMBL proteins: ENSP00000324419 ENSP00000434558 ENSP00000432141 ENSP00000379944 Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SYT9 for ontologies About GeneDecksing
SYT9 Antibody Products: Assay Products for SYT9: |
Protein
Domains / Families for SYT9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYT9 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86SS6ProtoNet protein and cluster: Q86SS6 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: SYT9_HUMAN, Q86SS6Similarity: Belongs to the synaptotagmin familySimilarity: Contains 2 C2 domains |
Function for SYT9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SYT9_HUMAN, Q86SS6Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid bindingto the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYT9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SYT9 (NM_175733) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYT9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT9  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT9 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SYT9 for ontologies About GeneDecksing
|
Pathways & Interactions for SYT9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
 5/10 Interacting proteins for SYT9 (Q86SS63 ENSP000003244194) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0017158 | regulation of calcium ion-dependent exocytosis |
IEA | -- | | GO:0050796 | regulation of insulin secretion |
IEA | -- |
SYT9 for ontologies About GeneDecksing
|
Drugs & Compounds for SYT9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SYT9 for compounds About GeneDecksing
Browse Tocris compounds for SYT9
1 HMDB Compound for SYT9 About this table 1 Novoseek chemical compound relationship for SYT9 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
5.82 |
1 |
14983047 (1) |
Search CenterWatch for drugs/clinical trials and news about SYT9 
|
Transcripts for SYT9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SYT9 gene: NM_175733.3 Unigene Cluster for SYT9: Synaptotagmin IX Hs.177193 [show with all ESTs]Unigene Representative Sequence: BC0463675 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529138 ENST00000318881(uc001mfe.3 uc009yfi.3) ENST00000532592 ENST00000524820(uc001mfd.3) ENST00000396716
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYT9 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SYT9 (NM_175733) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYT9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT9  |
Additional cDNA sequence: AK055003.1 AK055929.1 AK127795.1 AK315013.1 AL137512.1 BC046367.1 3 DOTS entries: DT.434225 DT.101955565 DT.99939354 23 AceView cDNA sequences: BC029605 AK055929 AL137512 Z39450 BI560415 BC046367 NM_175733 AI955186 CD250937 BE047105 BM561215 AK127795 BM928247 AK055003 H17258 BF197562 BX108745 BM553771 Z43379 BQ720470 H17257 H08332 H08235 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SYT9 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | |   |
ECgene alternative splicing isoforms for SYT9
|
Expression for SYT9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYT9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCAGGCAGGT
About this image See SYT9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SYT9
SOURCE GeneReport for Unigene cluster: Hs.177193 SABiosciences Custom PCR Arrays for SYT9
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYT9 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYT9 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYT9 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT9 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT9 |
Orthologs for SYT9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SYT9 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
SYT91 |
synaptotagmin IX |
81.06(n) 88.86(a) |
  |
423026 XM_003641313.1 XP_003641361.1 |
lizard (Anolis carolinensis) |
Reptilia |
SYT96 |
-- |
87(a) |
1 ↔ 1 |
GL343237.1(2046629-2087955) |
zebrafish (Danio rerio) |
Actinopterygii |
sbcb8442 |
sbcb844 |
72.16(n) |
  |
378858 BI475373.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Sytbeta6 |
Synaptotagmin beta |
18(a) |
possible ortholog |
3L(15007795-15058077) |
worm (Caenorhabditis elegans) |
Secernentea |
snt-66 |
SyNapTotagmin family member (snt-6) |
30(a) |
possible ortholog |
II(745469-750171) |
ENSEMBL Gene Tree for SYT9 (if available) TreeFam Gene Tree for SYT9 (if available)  |
Paralogs for SYT9 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SYT9 gene
- SYT152 SYT42 SYT52 SYT82 SYT32 SYT102 SYT62 SYT172
- SYT112 SYT122 SYT72 SYT22 SYT12
15 SIMAP similar genes for SYT9 using alignment to 6 protein entries: SYT9_HUMAN (see all proteins):SYT10 SYT2 SYT1 SYT6 SYT7 SYTL2 SYT5 CHR11SYT SYT4 SYT15 SYT3 SYT11 SYT17 SYT12 RPH3A
SYT9 for paralogs About GeneDecksing
|
Genomic Variants for SYT9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SYT9 (7260099 - 7490276 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for SYT9 4 CNVs: 101124 71274 101125 2904 2 Indels: 39802 44933  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT9 |
|
Disorders
/ Diseases for SYT9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SYT9 for disorders About GeneDecksing
OMIM gene information: 613528
OMIM disorders: --
3 diseases for SYT9: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis neuronitis Human Genome Epidemiology (HuGE) Navigator: SYT9 (1 document) Export disorders for SYT9 gene to outside databases
|
Publications for SYT9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYT9 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with SYT9) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 3 Craxton M.A. (2001)
- Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. (PubMed id 11751925)1, 9 Fukuda M....Mikoshiba K. (2002)
- Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (2012)
- Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. (PubMed id 21220648)2 Daoud H....Rouleau G.A. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. (PubMed id 15066994)1 Morenilla-Palao C....Ferrer-Montiel A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules. (PubMed id 12966166)1 Haberman Y....Sagi-Eisenberg R. (2003)
|
External Searches for SYT9 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SYT9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYT9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYT9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SYT9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYT9 gene: Search GeneIP for patents involving SYT9
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SYT9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | Search Tocris compounds for SYT9 |
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 | | SYT9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT9 |
|  |  |  | | | Search ThermoFisher Antibodies for SYT9 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT9 |
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