Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYT9 Gene

Aliases for SYT9 Gene

  • Synaptotagmin IX 2 3 4
  • SytIX 3 4
  • Synaptotagmin-9 3

External Ids for SYT9 Gene

Summaries for SYT9 Gene

GeneCards Summary for SYT9 Gene

SYT9 (Synaptotagmin IX) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and transporter activity. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT9 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Gene Wiki entry for SYT9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT9 Gene

Genomics for SYT9 Gene

Genomic Location for SYT9 Gene

7,238,778 bp from pter
7,469,045 bp from pter
230,268 bases
Plus strand

Genomic View for SYT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT9 Gene

Regulatory Elements for SYT9 Gene

Proteins for SYT9 Gene

  • Protein details for SYT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SYT9 Gene

    491 amino acids
    Molecular mass:
    56188 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    No Data Available

neXtProt entry for SYT9 Gene

Proteomics data for SYT9 Gene at MOPED

Post-translational modifications for SYT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT9 Gene

Domains for SYT9 Gene

Gene Families for SYT9 Gene

  • SYT :Synaptotagmins

Protein Domains for SYT9 Gene



  • Contains 2 C2 domains.:
    • Q86SS6
  • Belongs to the synaptotagmin family.:
    • Q86SS6
genes like me logo Genes that share domains with SYT9: view

Function for SYT9 Gene

Molecular function for SYT9 Gene

UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Gene Ontology (GO) - Molecular Function for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT9: view

miRNA for SYT9 Gene

miRTarBase miRNAs that target SYT9

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYT9 Gene

Localization for SYT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT9 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SYT9 Gene COMPARTMENTS Subcellular localization image for SYT9 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030141 secretory granule --
genes like me logo Genes that share ontologies with SYT9: view

Pathways for SYT9 Gene

SuperPathways for SYT9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0045956 positive regulation of calcium ion-dependent exocytosis IEA --
genes like me logo Genes that share ontologies with SYT9: view

No data available for Pathways by source for SYT9 Gene

Compounds for SYT9 Gene

(1) HMDB Compounds for SYT9 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Novoseek inferred chemical compound relationships for SYT9 Gene

Compound -log(P) Hits PubMed IDs
calcium 5.82 1
genes like me logo Genes that share compounds with SYT9: view

Transcripts for SYT9 Gene

Unigene Clusters for SYT9 Gene

Synaptotagmin IX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: - - -
SP3: - - - -

Relevant External Links for SYT9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT9 Gene

mRNA expression in normal human tissues for SYT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.2), Brain - Cerebellum (5.7), and Brain - Spinal cord (cervical c-1) (4.3).

SOURCE GeneReport for Unigene cluster for SYT9 Gene Hs.177193

genes like me logo Genes that share expressions with SYT9: view

Orthologs for SYT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT9 36
  • 99.73 (n)
  • 99.8 (a)
SYT9 37
  • 100 (a)
(Bos Taurus)
Mammalia SYT9 36
  • 94.1 (n)
  • 97.73 (a)
SYT9 37
  • 98 (a)
(Canis familiaris)
Mammalia SYT9 36
  • 94.43 (n)
  • 97.52 (a)
SYT9 37
  • 95 (a)
(Mus musculus)
Mammalia Syt9 36
  • 90.77 (n)
  • 97.56 (a)
Syt9 16
Syt9 37
  • 98 (a)
(Monodelphis domestica)
Mammalia SYT9 37
  • 89 (a)
(Rattus norvegicus)
Mammalia Syt9 36
  • 90.29 (n)
  • 97.35 (a)
(Gallus gallus)
Aves SYT9 36
  • 81.09 (n)
  • 89.07 (a)
SYT9 37
  • 79 (a)
(Anolis carolinensis)
Reptilia SYT9 37
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syt9 36
  • 75.72 (n)
  • 82.1 (a)
(Danio rerio)
Actinopterygii sbcb844 36
syt9a 37
  • 66 (a)
syt9b 36
  • 69.13 (n)
  • 75.56 (a)
syt9b 37
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt1 37
  • 33 (a)
(Caenorhabditis elegans)
Secernentea snt-1 37
  • 34 (a)
snt-2 37
  • 33 (a)
snt-3 37
  • 44 (a)
Species with no ortholog for SYT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT9 Gene

Gene Tree for SYT9 (if available)
Gene Tree for SYT9 (if available)

Paralogs for SYT9 Gene

Paralogs for SYT9 Gene

Selected SIMAP similar genes for SYT9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SYT9: view

Variants for SYT9 Gene

Sequence variations from dbSNP and Humsavar for SYT9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3282 -- 7,468,930(-) CCTCT(A/G)CTCAC utr-variant-3-prime
rs726733 -- 7,309,076(+) TAATT(A/G)TCTTT intron-variant
rs755831 -- 7,300,250(+) GTTTA(C/T)TCCTT intron-variant
rs765340 -- 7,363,598(+) gtgaa(A/G)agaaa intron-variant
rs765341 -- 7,364,051(+) AAATA(G/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT9 Gene

Variant ID Type Subtype PubMed ID
nsv896975 CNV Gain 21882294
esv23862 CNV Gain 19812545
nsv467702 CNV Gain 19166990
esv2450231 CNV Insertion 19546169
esv268316 CNV Insertion 20981092
esv274595 CNV Insertion 20981092
nsv896976 CNV Loss 21882294
essv1639 CNV CNV 17122850
esv2448178 CNV Deletion 19546169
esv2288433 CNV Deletion 18987734
esv2744079 CNV Deletion 23290073
esv269864 CNV Insertion 20981092
nsv525638 CNV Gain 19592680
dgv57n21 CNV Loss 19592680
esv2663215 CNV Deletion 23128226
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Relevant External Links for SYT9 Gene

HapMap Linkage Disequilibrium report

Disorders for SYT9 Gene

Relevant External Links for SYT9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SYT9: view

No data available for UniProtKB/Swiss-Prot for SYT9 Gene

Publications for SYT9 Gene

  1. Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. (PMID: 11751925) Fukuda M. … Mikoshiba K. (J. Biol. Chem. 2002) 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 49
  5. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3

Products for SYT9 Gene

Sources for SYT9 Gene

Back to Top