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Aliases for SYT9 Gene

Aliases for SYT9 Gene

  • Synaptotagmin 9 2 3 5
  • Synaptotagmin IX 2 3 4
  • SytIX 3 4

External Ids for SYT9 Gene

Previous GeneCards Identifiers for SYT9 Gene

  • GC00U906273
  • GC11P007229
  • GC11P007273
  • GC11P006931

Summaries for SYT9 Gene

GeneCards Summary for SYT9 Gene

SYT9 (Synaptotagmin 9) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT9 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT9 Gene

Genomics for SYT9 Gene

Regulatory Elements for SYT9 Gene

Genomic Location for SYT9 Gene

Chromosome:
11
Start:
7,238,778 bp from pter
End:
7,469,045 bp from pter
Size:
230,268 bases
Orientation:
Plus strand

Genomic View for SYT9 Gene

Genes around SYT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT9 Gene

Proteins for SYT9 Gene

  • Protein details for SYT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SS6-SYT9_HUMAN
    Recommended name:
    Synaptotagmin-9
    Protein Accession:
    Q86SS6

    Protein attributes for SYT9 Gene

    Size:
    491 amino acids
    Molecular mass:
    56188 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT10.

neXtProt entry for SYT9 Gene

Proteomics data for SYT9 Gene at MOPED

Post-translational modifications for SYT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SYT9 Gene

Domains & Families for SYT9 Gene

Gene Families for SYT9 Gene

Protein Domains for SYT9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SS6

UniProtKB/Swiss-Prot:

SYT9_HUMAN :
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
Domain:
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT9: view

Function for SYT9 Gene

Molecular function for SYT9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT9: view
genes like me logo Genes that share phenotypes with SYT9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT9 Gene

Localization for SYT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT9 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT9 Gene COMPARTMENTS Subcellular localization image for SYT9 gene
Compartment Confidence
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0030672 synaptic vesicle membrane IEA --
GO:0031045 dense core granule IEA --
genes like me logo Genes that share ontologies with SYT9: view

Pathways & Interactions for SYT9 Gene

SuperPathways for SYT9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT9: view

No data available for Pathways by source and SIGNOR curated interactions for SYT9 Gene

Drugs & Compounds for SYT9 Gene

(1) Drugs for SYT9 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYT9: view

Transcripts for SYT9 Gene

Unigene Clusters for SYT9 Gene

Synaptotagmin IX:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - - -
SP3: - - - -

Relevant External Links for SYT9 Gene

GeneLoc Exon Structure for
SYT9
ECgene alternative splicing isoforms for
SYT9

Expression for SYT9 Gene

mRNA expression in normal human tissues for SYT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.2), Brain - Cerebellum (x5.7), and Brain - Spinal cord (cervical c-1) (x4.3).

SOURCE GeneReport for Unigene cluster for SYT9 Gene Hs.177193

genes like me logo Genes that share expression patterns with SYT9: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SYT9 Gene

Orthologs for SYT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT9 35
  • 94.1 (n)
  • 97.73 (a)
SYT9 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT9 35
  • 94.43 (n)
  • 97.52 (a)
SYT9 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt9 35
  • 90.77 (n)
  • 97.56 (a)
Syt9 16
Syt9 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT9 35
  • 99.73 (n)
  • 99.8 (a)
SYT9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt9 35
  • 90.29 (n)
  • 97.35 (a)
oppossum
(Monodelphis domestica)
Mammalia SYT9 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT9 35
  • 81.09 (n)
  • 89.07 (a)
SYT9 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT9 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt9 35
  • 75.72 (n)
  • 82.1 (a)
zebrafish
(Danio rerio)
Actinopterygii sbcb844 35
syt9b 35
  • 69.13 (n)
  • 75.56 (a)
syt9a 36
  • 66 (a)
OneToMany
syt9b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syt1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-1 36
  • 34 (a)
ManyToMany
snt-2 36
  • 33 (a)
ManyToMany
snt-3 36
  • 44 (a)
ManyToMany
Species with no ortholog for SYT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT9 Gene

ENSEMBL:
Gene Tree for SYT9 (if available)
TreeFam:
Gene Tree for SYT9 (if available)

Paralogs for SYT9 Gene

Paralogs for SYT9 Gene

(15) SIMAP similar genes for SYT9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SYT9: view

Variants for SYT9 Gene

Sequence variations from dbSNP and Humsavar for SYT9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036390 A colorectal cancer sample
rs78477754 - 7,303,353(+) TCCGC(A/G)TGCAG reference, missense
VAR_065761 -
rs117876446 - 7,416,054(+) TGGAT(C/G)TGGGA reference, missense
rs3282 -- 7,468,930(-) CCTCT(A/G)CTCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYT9 Gene

Variant ID Type Subtype PubMed ID
nsv896975 CNV Gain 21882294
esv23862 CNV Gain 19812545
nsv467702 CNV Gain 19166990
esv2450231 CNV Insertion 19546169
esv268316 CNV Insertion 20981092
esv274595 CNV Insertion 20981092
nsv896976 CNV Loss 21882294
essv1639 CNV CNV 17122850
esv2448178 CNV Deletion 19546169
esv2288433 CNV Deletion 18987734
esv2744079 CNV Deletion 23290073
esv269864 CNV Insertion 20981092
nsv525638 CNV Gain 19592680
dgv57n21 CNV Loss 19592680
esv2663215 CNV Deletion 23128226
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241

Variation tolerance for SYT9 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT9 Gene

HapMap Linkage Disequilibrium report
SYT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT9 Gene

Disorders for SYT9 Gene

Relevant External Links for SYT9

Genetic Association Database (GAD)
SYT9
Human Genome Epidemiology (HuGE) Navigator
SYT9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT9

No disorders were found for SYT9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT9 Gene

Publications for SYT9 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48 67
  2. Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. (PMID: 11751925) Fukuda M. … Mikoshiba K. (J. Biol. Chem. 2002) 3 23
  3. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3

Products for SYT9 Gene

Sources for SYT9 Gene

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