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SYT8 Gene

protein-coding   GIFtS: 50
GCID: GC11P001849

Synaptotagmin VIII

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Synaptotagmin VIII1 2 3
synaptotagmin-82
sytVIII2
SytVIII3

External Ids:    HGNC: 192641   Entrez Gene: 900192   Ensembl: ENSG000001490437   OMIM: 6077195   UniProtKB: Q8NBV83   
ORGUL members:         

Export aliases for SYT8 gene to outside databases

Previous GC identifers: GC11M001967 GC11P001813 GC11P001818 GC11P001820 GC11P001811 GC11P001646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT8 Gene:
This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are
important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of
the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin
gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would
link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, Mar 2014)

GeneCards Summary for SYT8 Gene:
SYT8 (synaptotagmin VIII) is a protein-coding gene. Diseases associated with SYT8 include neuronitis. GO annotations related to this gene include calcium-dependent protein binding and transporter activity. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT8_HUMAN, Q8NBV8
Function: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal
tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of
exocytosis in insulin secreted cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT8 gene promoter:
         COUP-TF1   COUP   Lmo2   HNF-4alpha2   AP-4   Tal-1beta   Roaz   HNF-4alpha1   E47   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYT8 promoter sequence
   Search Chromatin IP Primers for SYT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

SYT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001849:  view genomic region     (about GC identifiers)

Start:
1,848,709 bp from pter      End:
1,858,751 bp from pter
Size:
10,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT8_HUMAN, Q8NBV8 (See protein sequence)
Recommended Name: Synaptotagmin-8  
Size: 401 amino acids; 44138 Da
Subunit: Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts
with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5-tetrakisphosphate (IP4). Binds to AP2 in a
Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent (By
similarity)
Sequence caution: Sequence=AAQ57209.1; Type=Miscellaneous discrepancy; Note=May be due to an intron retention;
Sequence=CAB70885.2; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it is a
pre-mRNA;
Secondary accessions: A6NFJ4 Q9NSV9
Alternative splicing: 2 isoforms:  Q8NBV8-4   Q8NBV8-1   (Variant in position: 143:R->Q (in dbSNP:rs907608). Variant in position: 152:T->M (in dbSNP:rs907609))

Explore the universe of human proteins at neXtProt for SYT8: NX_Q8NBV8

Explore proteomics data for SYT8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001277261.1  NP_001277262.1  NP_001277263.1  NP_612634.3  

    ENSEMBL proteins: 
     ENSP00000392469   ENSP00000387678   ENSP00000371394   ENSP00000371406   ENSP00000343691  
     ENSP00000405850   ENSP00000443325   ENSP00000414626  

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    Cloud-Clone Corp. CLIAs for SYT8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    2 InterPro protein domains:
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q8NBV8

    ProtoNet protein and cluster: Q8NBV8

    UniProtKB/Swiss-Prot: SYT8_HUMAN, Q8NBV8
    Domain: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity)
    Domain: The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding
    (By similarity)
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT8_HUMAN, Q8NBV8
    Function: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal
    tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of
    exocytosis in insulin secreted cells (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0048306calcium-dependent protein binding IEA--
         
    SYT8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SYT8:
     Cell cycle / mitosis defect 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT8

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT8_HUMAN, Q8NBV8: Cell membrane; Single-pass type III membrane protein (By similarity). Cytoplasmic vesicle,
    secretory vesicle, acrosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0016020membrane ----

    SYT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT8
    Interactions:

        Search GeneGlobe Interaction Network for SYT8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SYT8 (Q8NBV83 ENSP000003713944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007340acrosome reaction IEA--

    SYT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYT8 gene (4 alternative transcripts): 
    NM_001290332.1  NM_001290333.1  NM_001290334.1  NM_138567.4  

    Unigene Cluster for SYT8:

    Synaptotagmin VIII
    Hs.161031  [show with all ESTs]
    Unigene Representative Sequence: BM907017
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430303 ENST00000417052 ENST00000479276 ENST00000490707 ENST00000479089(uc001lud.2)
    ENST00000381968(uc001lue.1) ENST00000464897 ENST00000475245 ENST00000381978
    ENST00000341958 ENST00000424556 ENST00000482118(uc009ydb.2) ENST00000483280
    ENST00000494431 ENST00000535046 ENST00000436964(uc010qxb.1)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: SYT8 (NM_138567)
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      QuantiTect SYBR Green Assays in human, mouse, rat SYT8
      QuantiFast Probe-based Assays in human, mouse, rat SYT8

    Additional mRNA sequence: 

    AK293395.1 BC038591.1 BC144657.1 BC144659.1 BC144660.1 BC144661.1 

    8 DOTS entries:

    DT.97782207  DT.100752449  DT.40111962  DT.95283346  DT.100647944  DT.102822049  DT.100837849  DT.120723716 

    Selected AceView cDNA sequences (see all 33):

    CR622425 CR619379 AK075202 AK131292 CR596759 BX399734 CR601912 NM_138567 
    BX282124 BX396540 BC038591 BV194019 BU608388 BX378323 AL137708 CB321892 
    BM709614 BX399733 AI814253 BF847943 BX396061 AY353087 BX365067 BU683204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYT8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                              -     -           -     -                       -                           
    SP2:                                -     -                       -     -           -     -                                                   
    SP3:                                      -                       -     -           -     -                                                   
    SP4:                                      -                       -     -                                                                     
    SP5:                                -     -                       -     -                                                                     


    ECgene alternative splicing isoforms for SYT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTGTCTC
    SYT8 Expression
    About this image

    SYT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.161031
        Custom PCR Arrays for SYT8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYT8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt81 , 5 synaptotagmin VIII1, 5 77.34(n)1
    75.4(a)1
      7 (87.93 cM)5
    559251  NM_001285861.11  NP_001272790.11 
     1424348505 
    chicken
    (Gallus gallus)
    Aves SYT81 synaptotagmin VIII 61.49(n)
    50.69(a)
      423095  XM_004941442.1  XP_004941499.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYT86
    synaptotagmin VIII
    48(a)
    1 ↔ 1
    1(70734689-70762046)
    zebrafish
    (Danio rerio)
    Actinopterygii syt86
    synaptotagmin VIII
    44(a)
    1 ↔ 1
    25(32486949-32500006) ENSDARG00000009564


    ENSEMBL Gene Tree for SYT8 (if available)
    TreeFam Gene Tree for SYT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT8 gene
    SYT152  SYT42  SYT52  SYT92  SYT102  SYT32  SYT62  SYT172  
    SYT112  SYT122  SYT22  SYT72  SYT12  
    7 SIMAP similar genes for SYT8 using alignment to 8 protein entries:     SYT8_HUMAN (see all proteins):
    SYT2    SYT1    SYT5    SYT10    SYT11    SYT7
    SYT6

    SYT8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT8 (see all 198)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734109151,2
    C,F--1853792(+) GGTCTC/TCAGGG 1 -- us2k13Minor allele frequency- T:0.43WA CSA 122
    rs1925397751,2
    --1853844(+) GCGGAC/TGGCGC 1 -- us2k10--------
    rs1488510241,2
    C--1854039(+) TGGCCC/TGGGAG 1 -- us2k10--------
    rs71202821,2
    C,A--1854058(+) GCCGGC/TCGCGG 1 -- us2k13Minor allele frequency- T:0.12NA EA 242
    rs79420441,2
    C,F,A,H--1854087(+) CTCTCG/CCCGCC 1 -- us2k111Minor allele frequency- C:0.35NA WA CSA EA 378
    rs618671301,2
    C--1854093(+) CCGCCC/GGGCCC 1 -- us2k13Minor allele frequency- G:0.12NA EA 242
    rs1853265031,2
    --1854122(+) AGGAGG/TGGGGA 1 -- us2k10--------
    rs118282411,2
    C,F,H--1854128(+) GGGGAC/TGCCAG 1 -- us2k12Minor allele frequency- T:0.05NA WA 122
    rs618671311,2
    C--1854356(+) TCTGGC/TCGGCA 1 -- us2k13Minor allele frequency- T:0.11NA EA 242
    rs118199181,2
    C,F,H--1854391(+) GACCCA/GGCCCA 1 -- us2k16Minor allele frequency- G:0.01NS EA NA WA 532

    HapMap Linkage Disequilibrium report for SYT8 (1848709 - 1858751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYT8 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv984n71CNV Loss21882294
    dgv986n71CNV Loss21882294
    nsv896746CNV Loss21882294
    nsv522320CNV Loss19592680
    nsv896731CNV Loss21882294
    dgv985n71CNV Loss21882294
    nsv469926CNV Loss18288195
    nsv896737CNV Loss21882294
    esv29980CNV Loss17803354
    nsv896739CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607719    OMIM disorders: --

    1 disease for SYT8:    
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    neuronitis


    SYT8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYT8
    Human Genome Epidemiology (HuGE) Navigator: SYT8 (4 documents)

    Export disorders for SYT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT8 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SYT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. (PubMed id 7791877)1, 3 Li C....SA1dhof T.C. (Nature 1995)
    5. The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion. (PubMed id 24065953)1 Moghadam P.K. and Jackson M.B. (Front Endocrinol (Lausanne) 2013)
    6. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
    7. Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus. (PubMed id 22928559)1 Xu Z....Felsenfeld G. (amp 2012)
    8. Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. (PubMed id 21336277)1 Xu Z....Felsenfeld G. (amp 2011)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90019 HGNC: 19264 AceView: SYT8 Ensembl:ENSG00000149043 euGenes: HUgn90019
    ECgene: SYT8 H-InvDB: SYT8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYT8 gene:
    Search GeneIP for patents involving SYT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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