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SYT7 Gene

protein-coding   GIFtS: 55
GCID: GC11M061282

Synaptotagmin VII

(Previous name: prostate cancer associated protein 7)
(Previous symbol: PCANAP7)
  See SYT7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin VII1 2 3     IPCA72
PCANAP71 2 3     SYT-VII2
Prostate Cancer-Associated Protein 72 3     SYTVII2
IPCA-72 3     synaptotagmin-72
Prostate Cancer Associated Protein 71     SytVII3

External Ids:    HGNC: 115141   Entrez Gene: 90662   Ensembl: ENSG000000113477   OMIM: 6041465   UniProtKB: O435813   

Export aliases for SYT7 gene to outside databases

Previous GC identifers: GC11U990180 GC11M062798 GC11M061536 GC11M061060 GC11M061058 GC11M061039 GC11M057610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT7 Gene:
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that
mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in
rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been
associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SYT7 Gene:
SYT7 (synaptotagmin VII) is a protein-coding gene. Diseases associated with SYT7 include prostate cancer. GO annotations related to this gene include transporter activity and calcium ion binding. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT7_HUMAN, O43581
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
(By similarity)

Gene Wiki entry for SYT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT7 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT7 promoter sequence
   Search Chromatin IP Primers for SYT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13.1   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12-q13.1

SYT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061282:  view genomic region     (about GC identifiers)

Start:
61,282,785 bp from pter      End:
61,348,620 bp from pter
Size:
65,836 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT7_HUMAN, O43581 (See protein sequence)
Recommended Name: Synaptotagmin-7  
Size: 403 amino acids; 45501 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Interacts with SYNCRIP isoform 3 C-terminus (By similarity)
Sequence caution: Sequence=AAB92667.1; Type=Frameshift; Positions=6, 10, 15;
1 PDB 3D structure from and Proteopedia for SYT7:
2D8K (3D)    
Secondary accessions: F5GZU9 Q08AH6
Alternative splicing: 2 isoforms:  O43581-1   O43581-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYT7: NX_O43581

Explore proteomics data for SYT7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001238994.1  NP_004191.2  

    ENSEMBL proteins: 
     ENSP00000263846   ENSP00000444201   ENSP00000438171   ENSP00000441184   ENSP00000439694  
     ENSP00000444568   ENSP00000444019   ENSP00000437720   ENSP00000443576  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR001565 Synaptotagmin
     IPR015427 Synaptotagmin7
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry O43581

    ProtoNet protein and cluster: O43581

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT7_HUMAN, O43581
    Domain: The second C2 domain/C2B is responsible for SYNCRIP binding (By similarity)
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Find genes that share domains with SYT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT7_HUMAN, O43581
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
    (By similarity)

         Genatlas biochemistry entry for SYT7:
    synaptotagmin 7,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved
    in exocytosis and endocytosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SYT7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SYT7:
     Decreased CXCL12 induced migra 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Syt7):
     behavior/neurological  cellular  immune system  integument  muscle 
     normal  reproductive system 

    Find genes that share phenotypes with SYT7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Syt7tm1Nan for SYT7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT7
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    hsa-miR-579 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-3916 hsa-miR-3142 hsa-miR-629 hsa-miR-149
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT7_HUMAN, O43581: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    lysosome2
    plasma membrane2
    vacuole2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--
    GO:0005886plasma membrane IEA--
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SYT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT7
    Interactions:

        GeneGlobe Interaction Network for SYT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SYT7 (O435813 ENSP000002638464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    STX4Q128463, ENSP000003177144I2D: score=1 STRING: ENSP00000317714
    STX1AQ166233, ENSP000002228124I2D: score=1 STRING: ENSP00000222812
    STX3Q132773, ENSP000003385624I2D: score=1 STRING: ENSP00000338562
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001778plasma membrane repair IEA--
    GO:0017158regulation of calcium ion-dependent exocytosis ----
    GO:0045956positive regulation of calcium ion-dependent exocytosis IEA--
    GO:0050796regulation of insulin secretion IEA--

    Find genes that share ontologies with SYT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT7

    1 HMDB Compound for SYT7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for SYT7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 34.8 29 12034723 (6), 15456748 (3), 19030179 (1), 16166648 (1) (see all 8)
    catecholamine 22.3 1 16166648 (1)



    Find genes that share compounds with SYT7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYT7 gene (2 alternative transcripts): 
    NM_001252065.1  NM_004200.3  

    Unigene Cluster for SYT7:

    Synaptotagmin VII
    Hs.131188  [show with all ESTs]
    Unigene Representative Sequence: NM_001252065
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263846(uc009ynr.3 uc001nrv.3) ENST00000540677 ENST00000539246
    ENST00000539468 ENST00000539008 ENST00000542836(uc001nrx.1) ENST00000542670(uc001nrw.1)
    ENST00000535826 ENST00000540831 ENST00000545053
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SYT7 (see all 82):
    hsa-miR-579 hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-3916 hsa-miR-3142 hsa-miR-629 hsa-miR-149
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    Additional mRNA sequence: 

    AF038535.1 AK294636.1 AL137559.1 BC042495.1 BC125170.1 BC125171.1 Y19238.1 Y19240.1 

    4 DOTS entries:

    DT.97765536  DT.444726  DT.40126998  DT.446299 

    2 AceView cDNA sequences:

    Y19239 Y19237 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYT7 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                          -     -     -     -     -                                   -                                 
    SP2:                                -     -     -     -                                                                     
    SP3:                          -     -     -     -     -                                                                     
    SP4:                                                                                                                        
    SP5:                                            -                                                                           


    ECgene alternative splicing isoforms for SYT7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTGCTGT
    SYT7 Expression
    About this image


    SYT7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
             Metanephros
    SYT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131188

    UniProtKB/Swiss-Prot: SYT7_HUMAN, O43581
    Tissue specificity: Expressed in a variety of adult and fetal tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYT7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt71 , 5 synaptotagmin VII1, 5 92.74(n)1
    98.02(a)1
      19 (6.58 cM)5
    545251  NM_173068.21  NP_775091.21 
     103890905 
    chicken
    (Gallus gallus)
    Aves SYT76
    synaptotagmin VII
    50(a)
    1 ↔ 1
    5(377154-386630) ENSGALG00000013302
    lizard
    (Anolis carolinensis)
    Reptilia SYT76
    synaptotagmin VII
    61(a)
    1 ↔ 1
    GL343235.1(967443-1250731)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia syt71 synaptotagmin 7 73.48(n)
    79.79(a)
      780295  NM_001079366.1  NP_001072834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii syt7b1 synaptotagmin VIIb 67.61(n)
    70(a)
      100334336  NM_001245957.1  NP_001232886.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syt76
    Syt7
    43(a)
    1 ↔ 1
    4(299303-327107)
    worm
    (Caenorhabditis elegans)
    Secernentea snt-56
    Protein SNT-5 (snt-5) mRNA, complete cds
    24(a)
    many ↔ many
    V(1393125-1411616) WBGene00004925


    ENSEMBL Gene Tree for SYT7 (if available)
    TreeFam Gene Tree for SYT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT7 gene
    SYT152  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  
    SYT172  SYT112  SYT122  SYT22  SYT12  
    18 SIMAP similar genes for SYT7 using alignment to 8 protein entries:     SYT7_HUMAN (see all proteins):
    SYT6    SYT2    SYT10    SYT1    SYT5    SYT9
    SYT4    PRKCG    SYT11    SYT17    SYT15    SYT3
    DOC2A    DKFZp434D2429    CHR11SYT    SYTL2    SYT8    RASA4

    Find genes that share paralogs with SYT7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT7 (see all 1232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896297841,2
    --61280689(+) AGGGCA/GCTGGT 2 -- ds50010--------
    rs29438111,2
    C,F,A,H--61280720(+) TTCCTG/ACTGTG 2 -- ds500111Minor allele frequency- A:0.34NA WA CSA EA 375
    rs1826570291,2
    C--61280756(+) GGAGGC/TGGCAG 2 -- ds50010--------
    rs770462071,2
    F--61280865(+) GCTTGG/ATCCCT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs30191961,2
    C,F,A,H--61281036(+) CACCCT/CCTTCC 2 -- ds50019Minor allele frequency- C:0.37WA NA EA 372
    rs1868855801,2
    --61281240(+) GAACAC/TGTATG 2 -- ut310--------
    rs10575471,2
    C,F,A--61281287(-) CGTGTC/GTTGTG 2 -- ut3110Minor allele frequency- G:0.35NA WA CSA EA 370
    rs1116049711,2
    C,F--61281292(+) GACACG/AACACA 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs10575441,2
    C,A--61281373(-) CCGATG/ACCCCA 2 -- ut319Minor allele frequency- A:0.30MN NA CSA WA EA 550
    rs29244391,2
    C,F,A,H--61281430(-) TCCTGT/CGCTCC 2 -- ut3110Minor allele frequency- C:0.47NA WA EA 374

    HapMap Linkage Disequilibrium report for SYT7 (61282785 - 61348620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SYT7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv342CNV Insertion18451855
    nsv897603CNV Loss21882294
    nsv468582CNV Loss19166990
    nsv897604CNV Loss21882294
    nsv825938CNV Gain20364138
    nsv832178CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT7
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604146    OMIM disorders: --

    1 disease for SYT7:    
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    prostate cancer


    Find genes that share disorders with SYT7           About GenesLikeMe

    Genetic Association Database (GAD): SYT7
    Human Genome Epidemiology (HuGE) Navigator: SYT7 (3 documents)

    Export disorders for SYT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT7 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with SYT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. (PubMed id 9615227)1, 2, 3 Cooper P.R.... Shows T.B. (Genomics 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. (PubMed id 22966849)1 Brandt D.S....Knight J.D. (Biochemistry 2012)
    4. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. (PubMed id 21266332)1 Dai X.Q....MacDonald P.E. (Diabetes 2011)
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    6. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. (PubMed id 12071850)1 Fukuda M....Mikoshiba K. (Biochem. J. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi. (PubMed id 11342594)1 Caler E.V....Andrews N.W. (J. Exp. Med. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9066 HGNC: 11514 AceView: SYT7.1 Ensembl:ENSG00000011347 euGenes: HUgn9066
    ECgene: SYT7 H-InvDB: SYT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYT7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYT7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYT7 gene:
    Search GeneIP for patents involving SYT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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