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SYT6 Gene

protein-coding   GIFtS: 52
GCID: GC01M114631

Synaptotagmin VI

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin VI1 2 3
synaptotagmin-62
sytVI2
SytVI3

External Ids:    HGNC: 186381   Entrez Gene: 1482812   Ensembl: ENSG000001342077   OMIM: 6077185   UniProtKB: Q5T7P83   

Export aliases for SYT6 gene to outside databases

Previous GC identifers: GC01M115046 GC01M113515 GC01M113733 GC01M113931 GC01M113922 GC01M114346 GC01M114433 GC01M112489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT6 Gene:
The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain
structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are
involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component
of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been
found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for SYT6 Gene:
SYT6 (synaptotagmin VI) is a protein-coding gene. Diseases associated with SYT6 include clear cell renal cell carcinoma, and renal cell carcinoma. GO annotations related to this gene include transporter activity and protein homodimerization activity. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)

Gene Wiki entry for SYT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT6 gene promoter:
         SRF   FOXF2   SRF (504 AA)   NRSF form 1   Lmo2   NRSF form 2   GATA-1   CREB   HEN1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT6 promoter sequence
   Search Chromatin IP Primers for SYT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

SYT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M114631:  view genomic region     (about GC identifiers)

Start:
114,631,913 bp from pter      End:
114,696,541 bp from pter
Size:
64,629 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8 (See protein sequence)
Recommended Name: Synaptotagmin-6  
Size: 510 amino acids; 57325 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A,
STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By
similarity)
Secondary accessions: B1AMB8 B3KPK1
Alternative splicing: 2 isoforms:  Q5T7P8-1   Q5T7P8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYT6: NX_Q5T7P8

Explore proteomics data for SYT6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257734.1  NP_995320.1  

    ENSEMBL proteins: 
     ENSP00000476562   ENSP00000476507   ENSP00000477344   ENSP00000477325   ENSP00000476396  
     ENSP00000476616   ENSP00000477219   ENSP00000476324   ENSP00000376974   ENSP00000358560  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR028701 SYT6
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q5T7P8

    ProtoNet protein and cluster: Q5T7P8

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT6_HUMAN, Q5T7P8
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
    May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005544NOT calcium-dependent phospholipid binding IDA7791877
    GO:0019905syntaxin binding IDA7791877
    GO:0030276clathrin binding IDA7791877
         
    SYT6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT6:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Syt6):
     normal 

    SYT6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Syt6tm1Sud for SYT6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT6

    miRNA
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    Block miRNA regulation of human, mouse, rat SYT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT6 (see all 60):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-301a hsa-miR-192 hsa-miR-519a hsa-miR-3167 hsa-miR-186 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidSYT6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYT6

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT6 (NM_205848)
    Sino Biological Human cDNA Clone for SYT6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT6_HUMAN, Q5T7P8: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein (By similarity)
    SYT6_HUMAN, Q5T7P8: Isoform 1: Membrane; Single-pass membrane protein (By similarity). Note=Localized
    predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity)
    SYT6_HUMAN, Q5T7P8: Isoform 2: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    endoplasmic reticulum3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0016021integral component of membrane ISS--
    GO:0019898extrinsic component of membrane ISS--
    GO:0030054cell junction IEA--

    SYT6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT6
    Interactions:

        Search GeneGlobe Interaction Network for SYT6

    Selected Interacting proteins for SYT6 (Q5T7P83) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1Q9ULB13I2D: score=1 
    PRKCBP057713I2D: score=1 
    STX1AQ166233I2D: score=1 
    STX1BP612663I2D: score=1 
    STX3Q132773I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007340acrosome reaction ----
    GO:0060478acrosomal vesicle exocytosis IMP11437455

    SYT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT6

    1 HMDB Compound for SYT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYT6 gene (3 alternative transcripts): 
    NM_001270805.1  NM_205848.3  NM_001253772.1  

    Unigene Cluster for SYT6:

    Synaptotagmin VI
    Hs.370963  [show with all ESTs]
    Unigene Representative Sequence: NM_001270805
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000610121 ENST00000607941 ENST00000609117 ENST00000610096 ENST00000610222
    ENST00000608203 ENST00000609577 ENST00000608879 ENST00000393296(uc021osa.1)
    ENST00000369547(uc001eeu.3 uc021orz.1 uc001eev.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT6 (see all 60):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-301a hsa-miR-192 hsa-miR-519a hsa-miR-3167 hsa-miR-186 hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidSYT6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYT6
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    OriGene ORF clones in mouse, rat for SYT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT6 (NM_205848)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT6
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SYT6

    Additional mRNA sequence: 

    AK056448.1 AK096744.1 BC044948.1 

    5 DOTS entries:

    DT.100745611  DT.107939  DT.100725421  DT.107940  DT.100678014 

    Selected AceView cDNA sequences (see all 34):

    NM_205848 BQ777677 BQ777980 BC044948 BQ068182 F12220 CR594520 F09849 
    AL535655 BV195298 AW149740 AK056448 CA840960 AK096744 AV726171 BX093734 
    AI863338 BX431128 CA841217 AI762417 AL535654 N50928 D80666 AI223268 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SYT6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -     -     -     -                                                         
    SP2:                          -                                                         
    SP3:                                                                    -               
    SP4:                    -                                                               
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for SYT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGTTCCC
    SYT6 Expression
    About this image


    SYT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SYT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370963
        Custom PCR Arrays for SYT6
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYT6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt61 , 5 synaptotagmin VI1, 5 90.35(n)1
    96.94(a)1
      3 (45.45 cM)5
    545241  NM_018800.41  NP_061270.21 
     1035752315 
    chicken
    (Gallus gallus)
    Aves SYT61 synaptotagmin VI 78.63(n)
    86.84(a)
      428270  XM_425830.4  XP_425830.4 
    lizard
    (Anolis carolinensis)
    Reptilia SYT66
    synaptotagmin VI
    86(a)
    1 ↔ 1
    4(129850149-129999934)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188382 Xenopus laevis transcribed sequence with weak similarity more 89.22(n)    BG347110.1 
    zebrafish
    (Danio rerio)
    Actinopterygii syt6a1 synaptotagmin VIa 72.58(n)
    81.09(a)
      100149310  XM_001920428.2  XP_001920463.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55593 neurotransmitter secretion
    calcium-dependent phospholipid more
    43(a)
    (best of 2)
      36C11   --
    worm
    (Caenorhabditis elegans)
    Secernentea R12A1.23   -- 40(a)
    (best of 2)
      V(1393195-1411388)   --


    ENSEMBL Gene Tree for SYT6 (if available)
    TreeFam Gene Tree for SYT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT6 gene
    SYT152  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT172  
    SYT112  SYT122  SYT22  SYT72  SYT12  
    14 SIMAP similar genes for SYT6 using alignment to 8 protein entries:     SYT6_HUMAN (see all proteins):
    SYT10    SYT1    SYT2    SYT7    SYT9    SYT5
    SYT3    SYT4    DKFZp434D2429    SYT12    SYT11    CHR11SYT
    SYT8    SYT17

    SYT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT6 (see all 1642)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005277001,2
    --114631476(+) TGTTC-/TTTTTT 2 -- ds50010--------
    rs26298161,2
    C,F,A--114631484(+) TTTTTA/TAAAAA 2 -- ds50017Minor allele frequency- T:0.41NA WA EA 366
    rs1399778231,2
    --114631673(+) ACAGCA/GGAGCC 2 -- ds50010--------
    rs778142861,2
    C--114631769(+) CAGAAA/CAAAAA 2 -- ds50010--------
    rs778998481,2
    C--114631780(+) ACAAAA/CAAGCC 2 -- ds50010--------
    rs782018561,2
    C,F--114631842(+) ATTGAG/AAAGAA 2 -- ds50011Minor allele frequency- A:0.11WA 118
    rs24321,2
    C,F,O,A,H--114631980(+) ACAAAT/CGAGTA 2 -- ut31 ese3106Minor allele frequency- C:0.32NS NA EA PA EU CA WA 6806
    rs1813876091,2
    --114631981(+) CAAACA/GAGTAA 2 -- ut310--------
    rs1841410521,2
    --114632027(+) ATTAAC/TGTCCT 2 -- ut310--------
    rs38110171,2
    H--114632070(-) TTTCCG/AGGCTG 2 -- ut31 ese35Minor allele frequency- A:0.00EA NS 1920

    HapMap Linkage Disequilibrium report for SYT6 (114631913 - 114696541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SYT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2476CNV Insertion18451855
    esv23869CNV Loss19812545
    nsv528503CNV Loss19592680
    nsv517962CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607718    OMIM disorders: --

    11 diseases for SYT6:    
    About MalaCards
    clear cell renal cell carcinoma    renal cell carcinoma    bipolar disorder    tonsillitis
    obesity    schizophrenia    cerebritis    thyroiditis
    breast cancer    endotheliitis    prostatitis


    SYT6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYT6

    Export disorders for SYT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT6 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SYT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 3 Craxton M.A. (Genomics 2001)
    4. Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. (PubMed id 11437455)1, 9 Michaut M....Mayorga L.S. (Dev. Biol. 2001)
    5. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. (PubMed id 16111671)1, 9 Roggero C.M....Mayorga L.S. (Dev. Biol. 2005)
    6. Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. (PubMed id 23319801)1 Rafiq S....Eccles D. (Cancer Res. 2013)
    7. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 148281 HGNC: 18638 AceView: SYT6 Ensembl:ENSG00000134207 euGenes: HUgn148281
    ECgene: SYT6 H-InvDB: SYT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYT6 gene:
    Search GeneIP for patents involving SYT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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