External Ids for SYT6 Gene
Previous GeneCards Identifiers for SYT6 Gene
The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for SYT6 Gene
SYT6 (Synaptotagmin VI) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transporter activity. An important paralog of this gene is SYT5.
UniProtKB/Swiss-Prot for SYT6 Gene
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).