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Aliases for SYT6 Gene

Aliases for SYT6 Gene

  • Synaptotagmin VI 2 3 4
  • SytVI 3 4
  • Synaptotagmin-6 3

External Ids for SYT6 Gene

Summaries for SYT6 Gene

Entrez Gene Summary for SYT6 Gene

  • The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for SYT6 Gene

SYT6 (Synaptotagmin VI) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transporter activity. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT6 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Gene Wiki entry for SYT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT6 Gene

Genomics for SYT6 Gene

Genomic Location for SYT6 Gene

114,089,291 bp from pter
114,153,919 bp from pter
64,629 bases
Minus strand

Genomic View for SYT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT6 Gene

Regulatory Elements for SYT6 Gene

Proteins for SYT6 Gene

  • Protein details for SYT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B1AMB8
    • B3KPK1

    Protein attributes for SYT6 Gene

    510 amino acids
    Molecular mass:
    57325 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By similarity).

    Alternative splice isoforms for SYT6 Gene


neXtProt entry for SYT6 Gene

Proteomics data for SYT6 Gene at MOPED

Post-translational modifications for SYT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT6 Gene

Domains for SYT6 Gene

Gene Families for SYT6 Gene

  • SYT :Synaptotagmins

Protein Domains for SYT6 Gene



  • Contains 2 C2 domains.:
    • Q5T7P8
  • Belongs to the synaptotagmin family.:
    • Q5T7P8
genes like me logo Genes that share domains with SYT6: view

Function for SYT6 Gene

Molecular function for SYT6 Gene

UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Gene Ontology (GO) - Molecular Function for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005544 NOT calcium-dependent phospholipid binding IDA 7791877
GO:0019905 syntaxin binding IDA 7791877
genes like me logo Genes that share ontologies with SYT6: view
genes like me logo Genes that share phenotypes with SYT6: view

Animal Models for SYT6 Gene

MGI Knock Outs for SYT6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYT6 Gene

Localization for SYT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Isoform 1: Membrane; Single-pass membrane protein. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment. {ECO:0000250}.
Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for SYT6 Gene COMPARTMENTS Subcellular localization image for SYT6 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane ISS --
GO:0019898 extrinsic component of membrane ISS --
genes like me logo Genes that share ontologies with SYT6: view

Pathways for SYT6 Gene

SuperPathways for SYT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0007340 acrosome reaction --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT6: view

No data available for Pathways by source for SYT6 Gene

Compounds for SYT6 Gene

(1) HMDB Compounds for SYT6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with SYT6: view

Transcripts for SYT6 Gene

Unigene Clusters for SYT6 Gene

Synaptotagmin VI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for SYT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT6 Gene

mRNA expression in normal human tissues for SYT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT6 Gene

This gene is overexpressed in Brain - Hypothalamus (13.8), Brain - Nucleus accumbens (basal ganglia) (6.0), Brain - Caudate (basal ganglia) (5.4), Brain - Putamen (basal ganglia) (4.8), and Brain - Spinal cord (cervical c-1) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SYT6 Gene

SOURCE GeneReport for Unigene cluster for SYT6 Gene Hs.370963

genes like me logo Genes that share expressions with SYT6: view

Orthologs for SYT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT6 36
  • 99.53 (n)
  • 99.76 (a)
(Bos Taurus)
Mammalia SYT6 36
  • 90.78 (n)
  • 97.4 (a)
SYT6 37
  • 81 (a)
(Canis familiaris)
Mammalia SYT6 36
  • 89.78 (n)
  • 94.34 (a)
SYT6 37
  • 79 (a)
(Mus musculus)
Mammalia Syt6 36
  • 90.35 (n)
  • 96.94 (a)
Syt6 16
Syt6 37
  • 81 (a)
(Monodelphis domestica)
Mammalia SYT6 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Syt6 36
  • 90.12 (n)
  • 96.71 (a)
(Gallus gallus)
Aves SYT6 36
  • 78.63 (n)
  • 86.84 (a)
SYT6 37
  • 69 (a)
(Anolis carolinensis)
Reptilia SYT6 37
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18838 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5667 36
syt6 36
  • 73.49 (n)
  • 86.27 (a)
(Danio rerio)
Actinopterygii SYT6 (1 of 2) 37
  • 70 (a)
syt6a 36
  • 72.58 (n)
  • 81.09 (a)
syt6a 37
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt1 37
  • 32 (a)
CG3020 38
  • 35 (a)
CG5559 38
  • 43 (a)
(Caenorhabditis elegans)
Secernentea snt-1 37
  • 35 (a)
snt-2 37
  • 36 (a)
snt-3 37
  • 46 (a)
R12A1.2 38
  • 40 (a)
C08G5.4 38
  • 39 (a)
Species with no ortholog for SYT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT6 Gene

Gene Tree for SYT6 (if available)
Gene Tree for SYT6 (if available)

Paralogs for SYT6 Gene

Paralogs for SYT6 Gene

genes like me logo Genes that share paralogs with SYT6: view

Variants for SYT6 Gene

Sequence variations from dbSNP and Humsavar for SYT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2432 -- 114,089,358(+) ACAAA(C/T)GAGTA utr-variant-3-prime
rs3838 -- 114,155,472(-) AGGCG(A/C)ATAGG upstream-variant-2KB
rs475852 -- 114,134,061(+) CACAG(A/G)CAGCA intron-variant
rs476567 -- 114,134,095(+) GAGCA(A/G)CCTCC intron-variant
rs479359 -- 114,120,248(+) TCACT(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT6 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545
nsv528503 CNV Loss 19592680
nsv2476 CNV Insertion 18451855
nsv517962 CNV Loss 19592680

Relevant External Links for SYT6 Gene

HapMap Linkage Disequilibrium report

Disorders for SYT6 Gene

Relevant External Links for SYT6

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SYT6: view

No data available for UniProtKB/Swiss-Prot for SYT6 Gene

Publications for SYT6 Gene

  1. Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. (PMID: 11437455) Michaut M. … Mayorga L.S. (Dev. Biol. 2001) 3 23
  2. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. (PMID: 16111671) Roggero C.M. … Mayorga L.S. (Dev. Biol. 2005) 3 23
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SYT6 Gene

Sources for SYT6 Gene

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