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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYT6 Gene

protein-coding GIFtS: 53
GCID: GC01M114631

synaptotagmin VI

Explore 3 diseases affiliated with
SYT6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin VI¹ ² ³
Synaptotagmin-6¹
SytVI³
SytVI³

External Ids:	HGNC: 18638¹	Entrez Gene: 148281²	Ensembl: ENSG00000134207⁷	OMIM: 607718⁵	UniProtKB: Q5T7P8³

Export aliases for SYT6 gene to outside databases

Previous GC identifers: GC01M115046 GC01M113515 GC01M113733 GC01M113931 GC01M113922 GC01M114346 GC01M114433 GC01M112489

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYT6:

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure

that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in

calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory

machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene.

(provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate

Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)

Gene Wiki entry for SYT6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYT6 gene promoter:
SRF FOXF2 SRF (504 AA) NRSF form 1 Lmo2 NRSF form 2 GATA-1 CREB HEN1 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT6 promoter sequence

Search SABiosciences Chromatin IP Primers for SYT6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1

SYT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT6 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M114631: view genomic region (about GC identifiers)

Start:	114,631,914 bp from pter	End:	114,696,541 bp from pter
Size:	64,628 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8 (See protein sequence)

Recommended Name: Synaptotagmin-6

Size: 510 amino acids; 57325 Da

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)

Subunit: Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B

and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By

similarity)

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein

(By similarity)

Subcellular location: Isoform 1: Membrane; Single-pass membrane protein (By similarity). Note=Localized predominantly

to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity)

Subcellular location: Isoform 2: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By

similarity)

Secondary accessions: B1AMB8 B3KPK1

Alternative splicing: 2 isoforms: Q5T7P8-1 Q5T7P8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYT6: NX_Q5T7P8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T7P8

SYT6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001257734.1 NP_995320.1

ENSEMBL proteins:

ENSP00000358560 ENSP00000358559 ENSP00000358558 ENSP00000412443 ENSP00000389266

ENSP00000376974

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	Uscn Proteins for SYT6

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000300	peripheral to membrane of membrane fraction	--	--
GO:0005829	cytosol	ISS	--
GO:0005886	plasma membrane	ISS	--
GO:0016021	integral to membrane	ISS	--
GO:0019898	extrinsic to membrane	ISS	--

SYT6 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SYT6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYT6 for domains About GeneDecksing

5 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001565 Synaptotagmin

IPR018029 C2_membr_targeting

IPR020477 C2_dom

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q5T7P8

ProtoNet protein and cluster: Q5T7P8

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8

Similarity: Belongs to the synaptotagmin family

Similarity: Contains 2 C2 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYT6_HUMAN, Q5T7P8

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate

Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SYT6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT6
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT6 (see all 60):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-301a hsa-miR-192 hsa-miR-519a hsa-miR-3167 hsa-miR-186 hsa-miR-508-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SYT6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT6 (see all 7) OriGene shRNA RFP: SYT6 OriGene siRNA: SYT6
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT6

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005544	NOT calcium-dependent phospholipid binding	IDA	7791877
GO:0019905	syntaxin binding	IDA	7791877
GO:0030276	clathrin binding	IDA	7791877

SYT6 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SYT6:

Downregulation of NF-kappaB pa

Animal Models:
Mouse knock-out Syt6^tm1Sud for SYT6
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Syt6):

normal

SYT6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYT6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/6 Interacting proteins for SYT6 (Q5T7P8³ ENSP00000358559⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NRXN1	Q9ULB1³, ENSP00000385142⁴	I2D: score=1 STRING: ENSP00000385142
PRKCB	P05771³, ENSP00000305355⁴	I2D: score=1 STRING: ENSP00000305355
STX1A	Q16623³	I2D: score=1
STX1B	P61266³	I2D: score=1
STX3	Q13277³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007340	acrosome reaction	--	--
GO:0060478	acrosomal vesicle exocytosis	IMP	11437455

SYT6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYT6

1 HMDB Compound for SYT6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about SYT6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYT6 gene (3 alternative transcripts):

NM_001270805.1 NM_205848.3 NM_001253772.1

Unigene Cluster for SYT6:

Synaptotagmin VI

Hs.370963 [show with all ESTs]

Unigene Representative Sequence: NM_001270805

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369547(uc001eeu.3 uc021orz.1 uc001eev.3) ENST00000483203

ENST00000369546 ENST00000369545 ENST00000425037 ENST00000447981 ENST00000393296(uc021osa.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT6
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT6 (see all 60):
		hsa-miR-142-5p hsa-miR-607 hsa-miR-301a hsa-miR-192 hsa-miR-519a hsa-miR-3167 hsa-miR-186 hsa-miR-508-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SYT6 3' UTR sequence

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Additional cDNA sequence:

AK056448.1 AK096744.1 BC044948.1

5 DOTS entries:

DT.100745611 DT.107939 DT.100725421 DT.107940 DT.100678014

24/34 AceView cDNA sequences (see all 34):

BQ777677 BC044948 BQ777980 BQ068182 F12220 CR594520 NM_205848 BX431128

AL535655 AW149740 AV726171 AK096744 BX093734 AI863338 BV195298 CA840960

F09849 AK056448 N54629 AL535654 N50928 CD651934 D80666 CA841217

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SYT6 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b
SP1:			-		-		-		-
SP2:									-
SP3:																							-
SP4:							-
SP5:							-		-

ECgene alternative splicing isoforms for SYT6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGTTCCC

About this image

SYT6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Matrigel embedded cells (Derivation of cardio...)

See SYT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYT6

SOURCE GeneReport for Unigene cluster: Hs.370963

SABiosciences Custom PCR Arrays for SYT6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYT6 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SYT6¹	synaptotagmin VI	78.95(n) 87.22(a)		428270 XM_425830.3 XP_425830.3
lizard (Anolis carolinensis)	Reptilia	SYT6⁶	--	78(a)	1 ↔ 1	4(129853826-129949668)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18838²	Xenopus laevis transcribed sequence with weak similarity more	89.22(n)		BG347110.1
zebrafish (Danio rerio)	Actinopterygii	syt6a¹	synaptotagmin VIa	72.58(n) 81.09(a)		100149310 XM_001920428.1 XP_001920463.1
fruit fly (Drosophila melanogaster)	Insecta	CG5559³	neurotransmitter secretion calcium-dependent phospholipid more	43(a) (best of 2)		36C11 --
worm (Caenorhabditis elegans)	Secernentea	R12A1.2³	--	40(a) (best of 2)		V(1393195-1411388) --

ENSEMBL Gene Tree for SYT6 (if available)
TreeFam Gene Tree for SYT6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYT6 gene

SYT15² SYT4² SYT5² SYT8² SYT9² SYT3² SYT10² SYT17²

SYT11² SYT2² SYT12² SYT7² SYT1²

15 SIMAP similar genes for SYT6 using alignment to 4 protein entries: SYT6_HUMAN (see all proteins):

SYT10 SYT1 SYT2 SYT7 SYT9 SYT5

SYT3 SYT4 DKFZp434D2429 SYT12 RPH3A SYT11

CHR11SYT SYT8 SYT17

SYT6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200527700^1,2		--	114631476(+)	`TGTTC-/TTTTTT`	4	--	ds500¹		0	--	--	--	--
rs2629816^1,2	C,F,A,	--	114631484(+)	`TTTTTA/TAAAAA`	4	--	ds500¹		7		NA WA EA	366
rs139977823^1,2		--	114631673(+)	`ACAGCA/GGAGCC`	4	--	ds500¹		0	--	--	--	--
rs77814286^1,2	C,	--	114631769(+)	`CAGAAA/CAAAAA`	4	--	ds500¹		0	--	--	--	--
rs77899848^1,2	C,	--	114631780(+)	`ACAAAA/CAAGCC`	4	--	ds500¹		0	--	--	--	--
rs78201856^1,2	C,F,	--	114631842(+)	`ATTGAG/AAAGAA`	4	--	ds500¹		1		WA	118
rs2432^1,2	C,F,O,A,H,	--	114631980(+)	`ACAAAT/CGAGTA`	4	--	ut3¹ nc-transcript-variantese³		106		NS NA EA PA EU CA WA	6806
rs181387609^1,2		--	114631981(+)	`CAAACA/GAGTAA`	4	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs184141052^1,2		--	114632027(+)	`ATTAAC/TGTCCT`	4	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs3811017^1,2	H	--	114632070(-)	`TTTCCG/AGGCTG`	4	--	ut3¹ nc-transcript-variantese³		5		EA NS	1920

HapMap Linkage Disequilibrium report for SYT6 (114631914 - 114696541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SYT6
3 CNVs: 2322 3306 64644

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT6

DNA2.0 Custom Variant and Variant Library Synthesis for SYT6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYT6 for disorders           About GeneDecksing

OMIM gene information: 607718    OMIM disorders: --

3 diseases for SYT6:    About MalaCards

clear cell renal cell carcinoma renal cell carcinoma carcinoma

Export disorders for SYT6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYT6 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SYT6)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genomic analysis of synaptotagmin genes. (PubMed id 11543631)^{1, 3} Craxton M.A. (2001)
Synaptotagmin VI participates in the acrosome reaction of human spermatozoa. (PubMed id 11437455)^{1, 9} Michaut M....Mayorga L.S. (2001)
Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. (PubMed id 16111671)^{1, 9} Roggero C.M....Mayorga L.S. (2005)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Calcineurin-mediated dephosphorylation of synaptotagm in VI is necessary for acrosomal exocytosis. (PubMed id 20551332)¹ Castillo Bennett J....Mayorga L.S. (2010)
Identification of novel epigenetic markers for clear cell renal cell carcinoma. (PubMed id 18639284)¹ Dalgin G.S....Liou L.S. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 148281	HGNC: 18638	AceView: SYT6	Ensembl:ENSG00000134207	euGenes: HUgn148281
ECgene: SYT6	H-InvDB: SYT6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SYT6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYT6 gene
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Patent Information for SYT6 gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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