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SYT5 Gene

protein-coding   GIFtS: 59
GCID: GC19M055684

Synaptotagmin V

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin V1 2 3
Synaptotagmin 51 2
synaptotagmin-52
sytV2
SytV3

External Ids:    HGNC: 115131   Entrez Gene: 68612   Ensembl: ENSG000001299907   OMIM: 6007825   UniProtKB: O004453   

Export aliases for SYT5 gene to outside databases

Previous GC identifers: GC19M056548 GC19M056109 GC19M060360 GC19M060376 GC19M052007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT5 Gene:
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats
related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium.
Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium,
and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 (PubMed 7597049)).(supplied by
OMIM, Feb 2011)

GeneCards Summary for SYT5 Gene:
SYT5 (synaptotagmin V) is a protein-coding gene. GO annotations related to this gene include calcium-dependent phospholipid binding and protein heterodimerization activity. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT5_HUMAN, O00445
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic
recycling compartment to the cell surface (By similarity)

Gene Wiki entry for SYT5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT5 gene promoter:
         E2F-3a   E2F-1   E2F   NRSF form 1   E2F-2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT5 promoter sequence
   Search Chromatin IP Primers for SYT5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q|11p   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q

SYT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055684:  view genomic region     (about GC identifiers)

Start:
55,682,567 bp from pter      End:
55,691,809 bp from pter
Size:
9,243 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYT5_HUMAN, O00445 (See protein sequence)
Recommended Name: Synaptotagmin-5  
Size: 386 amino acids; 42900 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer. Can also form heterodimers with SYT6. Interacts with both alpha- and beta-tubulin (By
similarity)
Secondary accessions: B3KWJ8 Q86X72

Explore the universe of human proteins at neXtProt for SYT5: NX_O00445

Explore proteomics data for SYT5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003171.2  
    ENSEMBL proteins: 
     ENSP00000465576   ENSP00000346265   ENSP00000442896   ENSP00000469874   ENSP00000465304  
     ENSP00000465074   ENSP00000467685   ENSP00000465110  
    Reactome Protein details: O00445

    SYT5 Human Recombinant Protein Products:

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    Novus Biologicals SYT5 Protein
    Novus Biologicals SYT5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYT5

     
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    antibodies-online proteins for SYT5 (3 products) 

     
    antibodies-online peptides for SYT5

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    antibodies-online antibodies for SYT5 (30 products) 

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    Cloud-Clone Corp. CLIAs for SYT5
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    antibodies-online kits for SYT5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR028689 SYT5
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry O00445

    ProtoNet protein and cluster: O00445

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT5_HUMAN, O00445
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Find genes that share domains with SYT5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT5_HUMAN, O00445
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
    Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic
    recycling compartment to the cell surface (By similarity)

         Genatlas biochemistry entry for SYT5:
    synaptotagmin 5,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved
    in exocytosis and endocytosis

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0019905syntaxin binding IEA--
    GO:0030276clathrin binding IEA--
         
    Find genes that share ontologies with SYT5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT5:
     Increased cell number in G2M,   Increased mitotic index 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Syt5):
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with SYT5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Syt5tm2.1Sud for SYT5

       genOway: Develop your customized and physiologically relevant rodent model for SYT5

    miRNA
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    miRTarBase miRNAs that target SYT5:
    hsa-mir-335-5p (MIRT017244)

    Block miRNA regulation of human, mouse, rat SYT5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SYT5:
    hsa-miR-330-3p hsa-miR-219-5p hsa-miR-486-3p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYT5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYT5
    Predesigned siRNA for gene silencing in human, mouse, rat SYT5

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SYT5 (NM_003180)
    Sino Biological Human cDNA Clone for SYT5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT5_HUMAN, O00445: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein (By similarity). Recycling endosome membrane; Single-pass membrane protein (By similarity). Note=In mast
    cells, localizes to the endocytic recycling compartment (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    Find genes that share ontologies with SYT5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYT5 About    
    See pathways by source

    SuperPathContained pathways About
    1Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SYT5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SYT5
        Regulation of insulin secretion


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT5
    Interactions:

        Search GeneGlobe Interaction Network for SYT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SYT5 (O004452, 3 ENSP000003462654) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2EP193882, 3, ENSP000002155874MINT-8267096 I2D: score=2 STRING: ENSP00000215587
    RAB1AP628202, 3MINT-63964 I2D: score=4 
    SYT3Q9BQG13, ENSP000003409144I2D: score=1 STRING: ENSP00000340914
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    INS-IGF2ENSP000003489864STRING: ENSP00000348986
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0007268synaptic transmission TAS9177789
    GO:0017156calcium ion-dependent exocytosis IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0050796regulation of insulin secretion TAS--

    Find genes that share ontologies with SYT5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT5

    2 HMDB Compounds for SYT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Norepinephrine(-)-(R)-Norepinephrine (see all 32)51-41-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYT5 gene: 
    NM_003180.2  

    Unigene Cluster for SYT5:

    Synaptotagmin V
    Hs.631566  [show with all ESTs]
    Unigene Representative Sequence: AK125182
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590851 ENST00000354308(uc002qjn.1 uc002qjo.1) ENST00000592935
    ENST00000537500(uc002qjm.1 uc002qjp.2) ENST00000588305 ENST00000592956
    ENST00000590859 ENST00000587067 ENST00000585461 ENST00000589172 ENST00000592470

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYT5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SYT5:
    hsa-miR-330-3p hsa-miR-219-5p hsa-miR-486-3p hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYT5 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT5
      QuantiTect SYBR Green Assays in human, mouse, rat SYT5
      QuantiFast Probe-based Assays in human, mouse, rat SYT5

    Additional mRNA sequence: 

    AK125182.1 AK295337.1 AK313067.1 BC029962.1 BC033683.1 BC046157.1 DQ090951.1 Y19236.1 

    7 DOTS entries:

    DT.100028207  DT.100751864  DT.91717535  DT.99999711  DT.100028208  DT.100680535  DT.97770048 

    Selected AceView cDNA sequences (see all 125):

    CA952541 BI791528 BG654644 BQ288023 BU952031 BC046157 CA775993 BQ068269 
    BM353597 BM547597 CA843950 CA843197 CA950706 BU077952 BI751997 BM352480 
    H40912 BU074756 BU074472 BM311596 BU069281 BQ286227 BI712940 AI638801 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYT5 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:        -                                   -                                                               
    SP2:                                            -                                                               
    SP3:        -     -                             -                                                               
    SP4:                                            -                                                               
    SP5:                                      -     -                                                               


    ECgene alternative splicing isoforms for SYT5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCAACC
    SYT5 Expression
    About this image


    SYT5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Pancreas (Endocrine System)
    SYT5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631566
        Custom PCR Arrays for SYT5
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYT5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt51 , 5 synaptotagmin V1, 5 85.7(n)1
    91.8(a)1
      7 (2.62 cM)5
    534201  NM_016908.21  NP_058604.11 
     45397685 
    lizard
    (Anolis carolinensis)
    Reptilia SYT56
    synaptotagmin V
    57(a)
    1 ↔ 1
    GL343355.1(896857-939287)
    zebrafish
    (Danio rerio)
    Actinopterygii syt1b6
    syt5a6
    (see all 3)
    synaptotagmin Va
    (see all 3)
    48(a)
    47(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    18(6850465-6857041) ENSDARG00000042350
    3(32279358-32288143) ENSDARG00000037941


    ENSEMBL Gene Tree for SYT5 (if available)
    TreeFam Gene Tree for SYT5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT5 gene
    SYT152  SYT42  SYT92  SYT82  SYT102  SYT32  SYT62  SYT172  
    SYT112  SYT122  SYT22  SYT72  SYT12  
    Selected SIMAP similar genes for SYT5 using alignment to 8 protein entries:     SYT5_HUMAN (see all proteins) (see all similar genes):
    SYT2    SYT1    PRKCG    SYT10    SYT3    SYT7
    SYT6    SYT4    SYT17    SYT11    DOC2A    SYT9
    DKFZp434D2429    SYT12    SYT8    CHR11SYT    SYT15    UNC13D

    Find genes that share paralogs with SYT5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT5 (see all 262)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72586591,2
    C,F,H--55683977(+) TTCCCT/CGGCTC 1 -- int112Minor allele frequency- C:0.04NS EA NA WA 1312
    rs750022231,2
    F--55684169(+) GCAAGC/TGAGTG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1143678841,2
    F--55684186(+) TTCATG/AGACAA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs37868671,2
    C,F,H--55684200(-) GAGAAC/TTCCCT 1 -- int118Minor allele frequency- T:0.27NS EA NA WA 2342
    rs1894394981,2
    --55684218(+) CCTCAA/CAGCCA 1 -- int10--------
    rs37868661,2
    C,F,A,H--55684224(-) ACACGT/CTGGCT 1 -- int116Minor allele frequency- C:0.50NS EA NA WA CSA 1074
    rs1146934431,2
    F--55684226(+) CCAGCG/ATGTGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs736195421,2
    C,F--55684312(+) TGAGAG/CTGTGA 1 -- int12Minor allele frequency- C:0.21WA 120
    rs1807857261,2
    --55684316(+) AGTGTC/GAGGGA 1 -- int10--------
    rs72582871,2
    C,F,H--55684388(+) GCGAGC/TGCCCA 1 -- int111Minor allele frequency- T:0.04NS EA WA NA 1298

    HapMap Linkage Disequilibrium report for SYT5 (55682567 - 55691809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYT5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912453CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT5
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600782    OMIM disorders: --


    Find genes that share disorders with SYT5           About GenesLikeMe


    Export disorders for SYT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT5 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SYT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. (PubMed id 9177789)1, 2, 3, 9 Craxton M.A.... Goedert M. (Genomics 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer. (PubMed id 15820774)1, 9 Sreenath A.S....Reddanna P. (Clin. Biochem. 2005)
    5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    6. Cloning, expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of human synaptotagmin 5 C2A domain. (PubMed id 22102235)1 Qiu X....Gao Y. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011)
    7. Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. (PubMed id 20471030)1 Martins-de-Souza D....Turck C.W. (J Psychiatr Res 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6861 HGNC: 11513 AceView: SYT5 Ensembl:ENSG00000129990 euGenes: HUgn6861
    ECgene: SYT5 H-InvDB: SYT5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYT5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SYT5 gene:
    Search GeneIP for patents involving SYT5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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