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Aliases for SYT5 Gene

Aliases for SYT5 Gene

  • Synaptotagmin 5 2 3 5
  • Synaptotagmin V 2 3 4
  • SytV 3 4
  • Synaptotagmin-5 3

External Ids for SYT5 Gene

Previous GeneCards Identifiers for SYT5 Gene

  • GC19M056548
  • GC19M056109
  • GC19M060360
  • GC19M060376
  • GC19M055684
  • GC19M052007

Summaries for SYT5 Gene

Entrez Gene Summary for SYT5 Gene

  • Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SYT5 Gene

SYT5 (Synaptotagmin 5) is a Protein Coding gene. Among its related pathways are Metabolism and Integration of energy metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is SYT1.

UniProtKB/Swiss-Prot for SYT5 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Gene Wiki entry for SYT5 Gene

Additional gene information for SYT5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT5 Gene

Genomics for SYT5 Gene

GeneHancer (GH) Regulatory Elements for SYT5 Gene

Promoters and enhancers for SYT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055178 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 561.5 +0.9 916 1.8 ARID4B SIN3A ZNF766 E2F8 ZNF416 ZNF143 KLF13 PAF1 SP3 SP5 SYT5 TNNI3 TNNT1 ENSG00000239137
GH19I055180 Promoter 1 EPDnew 550.8 -0.1 -84 0.1 NRF1 ZSCAN4 NCOA1 USF2 REST MNT KLF4 SMARCB1 ZNF148 ZFHX2 SYT5 TNNI3 PTPRH
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.1 -73.4 -73418 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -206.4 -206423 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 PIR44435 TMEM238 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
GH19I055172 Promoter/Enhancer 1.3 Ensembl ENCODE 13.3 +6.8 6785 2.1 HDAC1 PKNOX1 ARNT SIN3A ZNF76 GLI4 ZBTB40 ZNF335 GLIS2 EGR1 SYT5 TNNT1 TMEM86B BRSK1 UBE2S RDH13 EPS8L1 ENSG00000239137 LOC101930593
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYT5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYT5 gene promoter:

Genomic Locations for SYT5 Gene

Genomic Locations for SYT5 Gene
chr19:55,171,199-55,180,441
(GRCh38/hg38)
Size:
9,243 bases
Orientation:
Minus strand
chr19:55,682,567-55,691,809
(GRCh37/hg19)

Genomic View for SYT5 Gene

Genes around SYT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT5 Gene

Proteins for SYT5 Gene

  • Protein details for SYT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00445-SYT5_HUMAN
    Recommended name:
    Synaptotagmin-5
    Protein Accession:
    O00445
    Secondary Accessions:
    • B3KWJ8
    • B7Z300
    • Q86X72

    Protein attributes for SYT5 Gene

    Size:
    386 amino acids
    Molecular mass:
    42900 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYT5 Gene

    Alternative splice isoforms for SYT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT5 Gene

Post-translational modifications for SYT5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SYT5 Gene

Domains & Families for SYT5 Gene

Gene Families for SYT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYT5 Gene

Suggested Antigen Peptide Sequences for SYT5 Gene

Graphical View of Domain Structure for InterPro Entry

O00445

UniProtKB/Swiss-Prot:

SYT5_HUMAN :
  • Belongs to the synaptotagmin family.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT5: view

Function for SYT5 Gene

Molecular function for SYT5 Gene

GENATLAS Biochemistry:
synaptotagmin 5,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

Phenotypes From GWAS Catalog for SYT5 Gene

Gene Ontology (GO) - Molecular Function for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005509 calcium ion binding IDA,IBA 27793683
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT5: view
genes like me logo Genes that share phenotypes with SYT5: view

Animal Models for SYT5 Gene

MGI Knock Outs for SYT5:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT5 Gene

Localization for SYT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT5 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT5 gene
Compartment Confidence
plasma membrane 4
endosome 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SYT5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYT5 Gene

Pathways & Interactions for SYT5 Gene

genes like me logo Genes that share pathways with SYT5: view

Pathways by source for SYT5 Gene

Gene Ontology (GO) - Biological Process for SYT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0007268 chemical synaptic transmission TAS 9177789
GO:0017158 regulation of calcium ion-dependent exocytosis IEA,IBA --
GO:0048488 synaptic vesicle endocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT5: view

No data available for SIGNOR curated interactions for SYT5 Gene

Drugs & Compounds for SYT5 Gene

(2) Drugs for SYT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Norepinephrine Approved Pharma 737
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SYT5: view

Transcripts for SYT5 Gene

Unigene Clusters for SYT5 Gene

Synaptotagmin V:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for SYT5 Gene

GeneLoc Exon Structure for
SYT5
ECgene alternative splicing isoforms for
SYT5

Expression for SYT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT5 Gene

mRNA differential expression in normal tissues according to GTEx for SYT5 Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Putamen (basal ganglia) (x5.7), Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Frontal Cortex (BA9) (x5.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Hippocampus (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.8), and Pituitary (x4.0).

Protein differential expression in normal tissues from HIPED for SYT5 Gene

This gene is overexpressed in Brain (53.1) and Bone (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYT5 Gene



Protein tissue co-expression partners for SYT5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYT5 Gene:

SYT5

SOURCE GeneReport for Unigene cluster for SYT5 Gene:

Hs.631566

Evidence on tissue expression from TISSUES for SYT5 Gene

  • Nervous system(4.8)
  • Pancreas(3.8)
genes like me logo Genes that share expression patterns with SYT5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT5 Gene

Orthologs for SYT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT5 33 34
  • 99.27 (n)
cow
(Bos Taurus)
Mammalia SYT5 33 34
  • 92.51 (n)
dog
(Canis familiaris)
Mammalia SYT5 33 34
  • 90.5 (n)
rat
(Rattus norvegicus)
Mammalia Syt5 33
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Syt5 33 16 34
  • 85.7 (n)
lizard
(Anolis carolinensis)
Reptilia SYT5 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt1b 34
  • 48 (a)
OneToMany
syt5a 34
  • 47 (a)
OneToMany
syt5b 34
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta syt 35
  • 59 (a)
CG5559 35
  • 40 (a)
CG3020 35
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea snt-1 35
  • 53 (a)
Y75B7AL.3 35
  • 53 (a)
F42G9.7 35
  • 45 (a)
C08G5.4 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8468 34
  • 52 (a)
OneToMany
Species where no ortholog for SYT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT5 Gene

ENSEMBL:
Gene Tree for SYT5 (if available)
TreeFam:
Gene Tree for SYT5 (if available)

Paralogs for SYT5 Gene

Paralogs for SYT5 Gene

genes like me logo Genes that share paralogs with SYT5: view

Variants for SYT5 Gene

Sequence variations from dbSNP and Humsavar for SYT5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000398942 -- 55,181,322(-) C/T upstream_transcript_variant
rs1000832513 -- 55,178,807(-) CCCC/CCC intron_variant
rs1000859461 -- 55,176,642(-) G/A intron_variant
rs1000953753 -- 55,176,902(-) G/A intron_variant
rs1001604146 -- 55,175,436(-) G/T intron_variant

Variation tolerance for SYT5 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SYT5 Gene

Disorders for SYT5 Gene

Additional Disease Information for SYT5

No disorders were found for SYT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT5 Gene

Publications for SYT5 Gene

  1. Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location. (PMID: 9177789) Craxton M … Goedert M (Genomics 1997) 2 3 4 22 58
  2. Structural analysis of Ca2+-binding pocket of synaptotagmin 5 C2A domain. (PMID: 27793683) Qiu X … Niu L (International journal of biological macromolecules 2017) 3 4 58
  3. Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer. (PMID: 15820774) Sreenath AS … Reddanna P (Clinical biochemistry 2005) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SYT5 Gene

Sources for SYT5 Gene

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