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SYT4 Gene

protein-coding   GIFtS: 58
GCID: GC18M040847

Synaptotagmin IV

  See SYT4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin IV1 2 3     sytIV2
HsT11922     KIAA13423
Synaptotagmin 42     SytIV3
synaptotagmin-42     

External Ids:    HGNC: 115121   Entrez Gene: 68602   Ensembl: ENSG000001328727   OMIM: 6001035   UniProtKB: Q9H2B23   

Export aliases for SYT4 gene to outside databases

Previous GC identifers: GC18M041053 GC18M040634 GC18M040735 GC18M039099 GC18M039101 GC18M037706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SYT4 Gene:
SYT4 (synaptotagmin IV) is a protein-coding gene. Diseases associated with SYT4 include pheochromocytoma. GO annotations related to this gene include clathrin binding and calcium ion binding. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Gene Wiki entry for SYT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT4 gene promoter:
         CREB   AML1a   FOXJ2 (long isoform)   FOXJ2   CUTL1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT4 promoter sequence
   Search Chromatin IP Primers for SYT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.3

SYT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M040847:  view genomic region     (about GC identifiers)

Start:
40,847,843 bp from pter      End:
40,857,615 bp from pter
Size:
9,773 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2 (See protein sequence)
Recommended Name: Synaptotagmin-4  
Size: 425 amino acids; 47958 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Sequence caution: Sequence=BAA92580.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SYT4:
1UGK (3D)    
Secondary accessions: Q9P2K4

Explore the universe of human proteins at neXtProt for SYT4: NX_Q9H2B2

Explore proteomics data for SYT4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065834.1  
    ENSEMBL proteins: 
     ENSP00000255224   ENSP00000466930   ENSP00000470516   ENSP00000472583  

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    Novus Biologicals SYT4 Proteins
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    Cloud-Clone Corp. Proteins for SYT4

     
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    LSBio Antibodies in human, mouse, rat for SYT4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR001565 Synaptotagmin
     IPR028683 SYT4
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2B2

    ProtoNet protein and cluster: Q9H2B2

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Find genes that share domains with SYT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT4_HUMAN, Q9H2B2
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IEA--
    GO:0001786phosphatidylserine binding IEA--
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SYT4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Syt4):
     behavior/neurological 

    Find genes that share phenotypes with SYT4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Syt4tm1Hahe for SYT4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYT4:
    hsa-let-7b-3p (MIRT038996), hsa-mir-106b-5p (MIRT020421), hsa-mir-142-3p (MIRT021609)

    Block miRNA regulation of human, mouse, rat SYT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT4 (see all 78):
    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidSYT4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYT4
    Predesigned siRNA for gene silencing in human, mouse, rat SYT4

    Gene Editing
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    OriGene ORF clones in mouse, rat for SYT4
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    GenScript: all cDNA clones in your preferred vector: SYT4 (NM_020783)
    Sino Biological Human cDNA Clone for SYT4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYT4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT4_HUMAN, Q9H2B2: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    Find genes that share ontologies with SYT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT4
    Interactions:

        Search GeneGlobe Interaction Network for SYT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SYT4 (Q9H2B22, 3 ENSP000002552244) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGTAO437652, 3, ENSP000002215664MINT-68022 I2D: score=5 STRING: ENSP00000221566
    CACNA1BQ009753, ENSP000002775494I2D: score=1 STRING: ENSP00000277549
    MAPK10P537793, ENSP000003521574I2D: score=1 STRING: ENSP00000352157
    MAPK9P459843, ENSP000003214104I2D: score=1 STRING: ENSP00000321410
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0007269neurotransmitter secretion IEA--
    GO:0031339negative regulation of vesicle fusion IEA--
    GO:0045955negative regulation of calcium ion-dependent exocytosis IEA--

    Find genes that share ontologies with SYT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT4

    1 HMDB Compound for SYT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for SYT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 37.7 1 15496596 (1)
    aspartate 37.3 5 15079862 (2), 9162066 (1), 10466723 (1)
    calcium 29.3 19 8626542 (5), 9162066 (2), 18046461 (2), 10466723 (2) (see all 7)
    serine 26.6 6 9162066 (2), 15079862 (2), 10466723 (1)
    phospholipid 14.3 5 8626542 (3), 9162066 (1)
    glutamate 0.298 1 15197251 (1)
    lipid 0 2 10466723 (1)



    Find genes that share compounds with SYT4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYT4 gene: 
    NM_020783.3  

    Unigene Cluster for SYT4:

    Synaptotagmin IV
    Hs.8059  [show with all ESTs]
    Unigene Representative Sequence: NM_020783
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255224(uc010dng.3 uc002law.3 uc010xcm.2) ENST00000586678
    ENST00000590752 ENST00000585604 ENST00000596867 ENST00000589479 ENST00000593720
    ENST00000591820
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SYT4 (see all 78):
    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidSYT4 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT4
      QuantiTect SYBR Green Assays in human, mouse, rat SYT4
      QuantiFast Probe-based Assays in human, mouse, rat SYT4

    Additional mRNA sequence: 

    AB037763.1 AF299075.1 AK291154.1 AK293791.1 AK297275.1 AK297379.1 AK299593.1 AK299652.1 
    AK309381.1 AK311335.1 AK311469.1 BC036538.2 

    4 DOTS entries:

    DT.448911  DT.121085608  DT.121085611  DT.91900098 

    Selected AceView cDNA sequences (see all 111):

    NM_020783 AI370743 BC036538 T34746 T33624 AA363845 AA084868 BQ879623 
    BU735881 AI306404 T34860 BM697728 AA054193 AA634047 Z39631 AA976133 
    AI339352 AB037763 AA907386 BX478664 BP361788 Z43564 AI912792 BX478345 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SYT4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                                  -                           
    SP2:                    -     -     -     -     -     -                           
    SP3:                    -                                                         
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for SYT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAATTGC
    SYT4 Expression
    About this image


    SYT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Midbrain tegmentum
             N2/LSB/S/F8/CHIR-induced cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Neurons
             Midbrain dopaminergic-like neurons
    SYT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8059

    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Tissue specificity: Expressed in brain. Within brain, expression is highest in hippocampus, with substantial
    levels also detected in amygdala and thalamus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYT4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt41 , 5 synaptotagmin IV1, 5 85.88(n)1
    89.88(a)1
      18 (17.75 cM)5
    209831  NM_009308.31  NP_033334.21 
     314378085 
    chicken
    (Gallus gallus)
    Aves SYT41 synaptotagmin IV 80.94(n)
    88(a)
      422960  XM_420894.4  XP_420894.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYT46
    synaptotagmin IV
    64(a)
    1 ↔ 1
    1(36413127-36429340)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.90432 Transcribed sequence with moderate similarity to protein spQ9H2B2 (H.sapiens) SYT4_HUMAN Synaptotagmin IV (SytIV) less 76.64(n)    CF783621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj05d112 wufj05d11 75.15(n)   335357  BC059580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SytIV3 synaptic vesicle exocytosis
    calcium-dependent phospholipid binding less
    49(a)   84D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T23H2.23 C2 domain protein 38(a)   I(6444216-6448962)   --


    ENSEMBL Gene Tree for SYT4 (if available)
    TreeFam Gene Tree for SYT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT4 gene
    SYT152  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  SYT172  
    SYT112  SYT122  SYT22  SYT72  SYT12  
    Selected SIMAP similar genes for SYT4 using alignment to 4 protein entries:     SYT4_HUMAN (see all proteins) (see all similar genes):
    SYT11    SYT5    SYT9    SYT1    SYT7    SYTL4
    SYT10    SYT2    SYT6    PRKCB    PIK3C2B    PRKCG
    SYT17    DKFZp434D2429    SYT3    SYTL2    CHR11SYT    PRKCA

    Find genes that share paralogs with SYT4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT4 (see all 217)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455884011,2
    --40847604(+) CTATTC/TCTTCC 1 -- int10--------
    rs1488708331,2
    --40847612(+) TCCTAA/CTTGAT 1 -- int10--------
    rs1888269481,2
    --40847633(+) ATGCTC/TCTTGA 1 -- int10--------
    rs1159087521,2
    C,F--40847699(+) TTATGA/GAGATT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs169774351,2
    C,F--40847719(+) GGTGTA/GTTAAA 1 -- int15Minor allele frequency- G:0.21NA EA 382
    rs169774381,2
    C,F,H--40847762(+) CCTATA/GCAAGG 1 -- int111Minor allele frequency- G:0.06NA NS EA WA CSA 685
    rs1820280531,2
    --40847803(+) CAGCAA/GTAAGA 1 -- int10--------
    rs177217151,2
    C,F,H--40847908(+) CAAACA/CTCATA 1 -- ut31 ese314Minor allele frequency- C:0.01NA NS EA 1244
    rs2021262631,2
    C--40847925(-) CTTTTG/TTGCCA 1 -- ut310--------
    rs1869044971,2
    --40848055(+) GTGGTA/GAGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT4 (40847843 - 40857615 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SYT4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT4
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600103    OMIM disorders: --

    1 disease for SYT4:    
    About MalaCards
    pheochromocytoma

    1 disease from the University of Copenhagen DISEASES database for SYT4:
    Bipolar disorder

    Find genes that share disorders with SYT4           About GenesLikeMe

    1 Novoseek inferred disease relationship for SYT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 30.5 2 15079862 (1)

    Genetic Association Database (GAD): SYT4
    Human Genome Epidemiology (HuGE) Navigator: SYT4 (1 document)

    Export disorders for SYT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT4 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with SYT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. (PubMed id 10938284)1, 2, 9 Ferguson G.D.... Herschman H.R. (J. Biol. Chem. 2000)
    2. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. A third synaptotagmin gene, Syt3, in the mouse. (PubMed id 8058779)1, 3 Hilbush B.S. and Morgan J.I. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    6. Functional properties of multiple synaptotagmins in brain. (PubMed id 7993622)1, 9 Ullrich B....SA1dhof T.C. (Neuron 1994)
    7. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (PubMed id 21042317)4 Wray N.R....Sullivan P.F. (Mol. Psychiatry 2012)
    8. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (PLoS Genet. 2011)
    9. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. (PubMed id 21315262)1 Zhang G....Cai D. (Neuron 2011)
    10. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6860 HGNC: 11512 AceView: SYT4 Ensembl:ENSG00000132872 euGenes: HUgn6860
    ECgene: SYT4 H-InvDB: SYT4

    (According to HUGE)
    About This Section

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    HUGE: KIAA1342

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SYT4 gene:
    Search GeneIP for patents involving SYT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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