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Aliases for SYT4 Gene

Aliases for SYT4 Gene

  • Synaptotagmin IV 2 3 4
  • SytIV 3 4
  • Synaptotagmin 4 3
  • KIAA1342 4
  • HsT1192 3

External Ids for SYT4 Gene

Previous GeneCards Identifiers for SYT4 Gene

  • GC18M041053
  • GC18M040634
  • GC18M040735
  • GC18M039099
  • GC18M039101
  • GC18M040847
  • GC18M037706

Summaries for SYT4 Gene

GeneCards Summary for SYT4 Gene

SYT4 (Synaptotagmin IV) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT4 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for SYT4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT4 Gene

Genomics for SYT4 Gene

Regulatory Elements for SYT4 Gene

Genomic Location for SYT4 Gene

Chromosome:
18
Start:
43,267,878 bp from pter
End:
43,277,650 bp from pter
Size:
9,773 bases
Orientation:
Minus strand

Genomic View for SYT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT4 Gene

Proteins for SYT4 Gene

  • Protein details for SYT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2B2-SYT4_HUMAN
    Recommended name:
    Synaptotagmin-4
    Protein Accession:
    Q9H2B2
    Secondary Accessions:
    • B4DEU3
    • Q9P2K4

    Protein attributes for SYT4 Gene

    Size:
    425 amino acids
    Molecular mass:
    47958 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYT4 Gene

    Alternative splice isoforms for SYT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT4 Gene

Proteomics data for SYT4 Gene at MOPED

Post-translational modifications for SYT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT4 Gene

No data available for DME Specific Peptides for SYT4 Gene

Domains & Families for SYT4 Gene

Gene Families for SYT4 Gene

Protein Domains for SYT4 Gene

Suggested Antigen Peptide Sequences for SYT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2B2

UniProtKB/Swiss-Prot:

SYT4_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT4: view

Function for SYT4 Gene

Molecular function for SYT4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology (GO) - Molecular Function for SYT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0001786 phosphatidylserine binding IEA --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
genes like me logo Genes that share ontologies with SYT4: view
genes like me logo Genes that share phenotypes with SYT4: view

Animal Models for SYT4 Gene

MGI Knock Outs for SYT4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SYT4 Gene

Localization for SYT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT4 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT4 Gene COMPARTMENTS Subcellular localization image for SYT4 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SYT4: view

Pathways & Interactions for SYT4 Gene

SuperPathways for SYT4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007269 neurotransmitter secretion --
GO:0007420 brain development IEA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0031339 negative regulation of vesicle fusion IEA --
genes like me logo Genes that share ontologies with SYT4: view

No data available for Pathways by source and SIGNOR curated interactions for SYT4 Gene

Drugs & Compounds for SYT4 Gene

(3) Drugs for SYT4 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Forskolin Experimental Pharma 0
Calcium Nutra 0
serine Nutra 420

(4) Additional Compounds for SYT4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
aspartate
glutamate
LIPID
Phospholipid
genes like me logo Genes that share compounds with SYT4: view

Transcripts for SYT4 Gene

Unigene Clusters for SYT4 Gene

Synaptotagmin IV:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for SYT4 Gene

GeneLoc Exon Structure for
SYT4
ECgene alternative splicing isoforms for
SYT4

Expression for SYT4 Gene

mRNA expression in normal human tissues for SYT4 Gene

mRNA differential expression in normal tissues according to GTEx for SYT4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.8), Brain - Cerebellum (x7.7), Brain - Frontal Cortex (BA9) (x5.3), Brain - Hypothalamus (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for SYT4 Gene

This gene is overexpressed in Heart (61.9) and Adipocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYT4 Gene



SOURCE GeneReport for Unigene cluster for SYT4 Gene Hs.8059

mRNA Expression by UniProt/SwissProt for SYT4 Gene

Q9H2B2-SYT4_HUMAN
Tissue specificity: Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003).
genes like me logo Genes that share expression patterns with SYT4: view

Protein tissue co-expression partners for SYT4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT4 35
  • 90.12 (n)
  • 92.47 (a)
SYT4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT4 35
  • 91.92 (n)
  • 95.29 (a)
SYT4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt4 35
  • 85.88 (n)
  • 89.88 (a)
Syt4 16
Syt4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT4 35
  • 99.84 (n)
  • 100 (a)
SYT4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt4 35
  • 86.12 (n)
  • 89.88 (a)
oppossum
(Monodelphis domestica)
Mammalia SYT4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT4 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT4 35
  • 80.94 (n)
  • 88 (a)
SYT4 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT4 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9043 35
syt4 35
  • 75.16 (n)
  • 82.55 (a)
zebrafish
(Danio rerio)
Actinopterygii syt4 35
  • 64.61 (n)
  • 68.01 (a)
wufj05d11 35
syt4 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SytIV 37
  • 49 (a)
Syt4 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T23H2.2 37
  • 38 (a)
snt-4 36
  • 32 (a)
OneToMany
Species with no ortholog for SYT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT4 Gene

ENSEMBL:
Gene Tree for SYT4 (if available)
TreeFam:
Gene Tree for SYT4 (if available)

Paralogs for SYT4 Gene

Paralogs for SYT4 Gene

genes like me logo Genes that share paralogs with SYT4: view

Variants for SYT4 Gene

Sequence variations from dbSNP and Humsavar for SYT4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2456 -- 43,269,228(-) AATAT(A/G)CTTAG utr-variant-3-prime
rs816752 -- 43,273,034(+) GTAGT(A/G)TAACT intron-variant
rs1518140 -- 43,277,479(+) CCTGT(G/T)TTGGC utr-variant-5-prime
rs3177123 -- 43,270,095(-) CCAGT(A/G)ATATA utr-variant-3-prime
rs3744959 -- 43,270,331(-) CTAGC(C/T)GTGAG utr-variant-3-prime

Variation tolerance for SYT4 Gene

Residual Variation Intolerance Score: 40.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT4 Gene

HapMap Linkage Disequilibrium report
SYT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SYT4 Gene

Disorders for SYT4 Gene

Relevant External Links for SYT4

Genetic Association Database (GAD)
SYT4
Human Genome Epidemiology (HuGE) Navigator
SYT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT4
genes like me logo Genes that share disorders with SYT4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT4 Gene

Publications for SYT4 Gene

  1. Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. (PMID: 20010821) Johnson S.L. … Marcotti W. (Nat. Neurosci. 2010) 23 67
  2. Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells. (PMID: 18468511) Hu Z.T. … Wu Z.X. (Biochem. Biophys. Res. Commun. 2008) 23 67
  3. Stimulation inhibits the mobility of recycling peptidergic vesicles in astrocytes. (PMID: 17990309) Potokar M. … Zorec R. (Glia 2008) 23 67
  4. JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release. (PMID: 18046461) Mori Y. … Gotoh Y. (EMBO J. 2008) 23 67
  5. Genome-wide transcriptome profiling of region-specific vulnerability to oxidative stress in the hippocampus. (PMID: 17553663) Wang X. … Michaelis E.K. (Genomics 2007) 23 67

Products for SYT4 Gene

Sources for SYT4 Gene

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