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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT4 Gene

protein-coding   GIFtS: 58
GCID: GC18M040847

Synaptotagmin IV

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin IV1 2 3     sytIV2
HsT11922     KIAA13423
Synaptotagmin 42     SytIV3
synaptotagmin-42     

External Ids:    HGNC: 115121   Entrez Gene: 68602   Ensembl: ENSG000001328727   OMIM: 6001035   UniProtKB: Q9H2B23   

Export aliases for SYT4 gene to outside databases

Previous GC identifers: GC18M041053 GC18M040634 GC18M040735 GC18M039099 GC18M039101 GC18M037706


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYT4 Gene: 
SYT4 (synaptotagmin IV) is a protein-coding gene. Diseases associated with SYT4 include pheochromocytoma, and parkinson's disease. GO annotations related to this gene include clathrin binding and calcium ion binding. An important paralog of this gene is DOC2B.

UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Gene Wiki entry for SYT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT4 gene promoter:
         CREB   AML1a   FOXJ2 (long isoform)   FOXJ2   CUTL1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.3

SYT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M040847:  view genomic region     (about GC identifiers)

Start:
40,847,843 bp from pter      End:
40,857,615 bp from pter
Size:
9,773 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2 (See protein sequence)
Recommended Name: Synaptotagmin-4  
Size: 425 amino acids; 47958 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
protein
Sequence caution: Sequence=BAA92580.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SYT4:
1UGK (3D)    
Secondary accessions: Q9P2K4

Explore the universe of human proteins at neXtProt for SYT4: NX_Q9H2B2

Explore proteomics data for SYT4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2B2

  • SYT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYT4 Protein Expression
    REFSEQ proteins: NP_065834.1  
    ENSEMBL proteins: 
     ENSP00000255224   ENSP00000466930   ENSP00000470516   ENSP00000472583  

    Human Recombinant Protein Products for SYT4: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SYT4
    Cloud-Clone Corp. Proteins for SYT4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    SYT4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SYT: Synaptotagmins

    4 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9H2B2

    ProtoNet protein and cluster: Q9H2B2

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT4_HUMAN, Q9H2B2
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0030276clathrin binding IEA--
         
    SYT4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Syt4):
     behavior/neurological 

    SYT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Syt4tm1Hahe for SYT4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYT4 
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    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidSYT4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for SYT4 (Q9H2B22, 3 ENSP000002552244) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGTAO437652, 3, ENSP000002215664MINT-68022 I2D: score=5 STRING: ENSP00000221566
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    STX4Q128463, ENSP000003177144I2D: score=1 STRING: ENSP00000317714
    TFAP2BQ924813, ENSP000003772654I2D: score=1 STRING: ENSP00000377265
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007269neurotransmitter secretion IEA--

    SYT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYT4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT4

    1 HMDB Compound for SYT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 Novoseek inferred chemical compound relationships for SYT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 37.7 1 15496596 (1)
    aspartate 37.3 5 15079862 (2), 9162066 (1), 10466723 (1)
    calcium 29.3 19 8626542 (5), 9162066 (2), 18046461 (2), 10466723 (2) (see all 7)
    serine 26.6 6 9162066 (2), 15079862 (2), 10466723 (1)
    phospholipid 14.3 5 8626542 (3), 9162066 (1)
    glutamate 0.298 1 15197251 (1)
    lipid 0 2 10466723 (1)

    Search CenterWatch for drugs/clinical trials and news about SYT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYT4 gene: 
    NM_020783.3  

    Unigene Cluster for SYT4:

    Synaptotagmin IV
    Hs.8059  [show with all ESTs]
    Unigene Representative Sequence: NM_020783
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255224(uc010dng.3 uc002law.3 uc010xcm.2) ENST00000586678
    ENST00000590752 ENST00000585604 ENST00000596867 ENST00000589479 ENST00000593720
    ENST00000591820

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    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidSYT4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB037763.1 AF299075.1 AK291154.1 AK293791.1 AK297275.1 AK297379.1 AK299593.1 AK299652.1 
    AK309381.1 AK311335.1 AK311469.1 BC036538.2 

    4 DOTS entries:

    DT.448911  DT.121085608  DT.121085611  DT.91900098 

    24/111 AceView cDNA sequences (see all 111):

    T33624 AA907386 AB037763 BQ879623 BX478664 BX478345 AI339352 AA084868 
    Z39631 AI370743 BU735881 AI912792 AI306404 BM697728 AA634047 AA976133 
    Z43564 NM_020783 AA363845 BC036538 BP361788 AA054193 T34860 T34746 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SYT4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                                  -                           
    SP2:                    -     -     -     -     -     -                           
    SP3:                    -                                                         
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for SYT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT4 expression in normal human tissues (normalized intensities)      SYT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAATTGC
    SYT4 Expression
    About this image


    SYT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Septum   
     
     Neuron (Nervous System)    fully expand to see all 3 entries
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Neuron (HN)   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             PERIPHERAL NERVOUS SYSTEM   

    See SYT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT4

    SOURCE GeneReport for Unigene cluster: Hs.8059

    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Tissue specificity: Expressed in brain. Within brain, expression is highest in hippocampus, with substantial
    levels also detected in amygdala and thalamus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYT4 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt41 , 5 synaptotagmin IV1, 5 85.88(n)1
    89.88(a)1
      18 (17.75 cM)5
    209831  NM_009308.31  NP_033334.21 
     314378085 
    chicken
    (Gallus gallus)
    Aves SYT41 synaptotagmin IV 80.94(n)
    88(a)
      422960  XM_420894.3  XP_420894.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYT46
    Uncharacterized protein
    64(a)
    1 ↔ 1
    1(36413127-36429340)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.90432 Transcribed sequence with moderate similarity to protein spQ9H2B2 (H.sapiens) SYT4_HUMAN Synaptotagmin IV (SytIV) less 76.64(n)    CF783621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj05d112 wufj05d11 75.15(n)   335357  BC059580.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SytIV3 synaptic vesicle exocytosis
    calcium-dependent phospholipid binding less
    49(a)   84D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T23H2.23 C2 domain protein 38(a)   I(6444216-6448962)   --


    ENSEMBL Gene Tree for SYT4 (if available)
    TreeFam Gene Tree for SYT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT4 gene
    DOC2B2  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  SYT172  
    SYT112  SYT122  SYT22  DOC2A2  SYT72  RPH3A2  SYT12  
    18/22 SIMAP similar genes for SYT4 using alignment to 4 protein entries:     SYT4_HUMAN (see all proteins) (see all similar genes):
    SYT11    SYT9    SYT5    SYT1    SYT7    SYTL4
    SYT10    SYT2    SYT6    PRKCB    PIK3C2B    PRKCG
    SYT17    DKFZp434D2429    SYT3    RPH3A    SYTL2    CHR11SYT

    SYT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 SNPs in SYT4 are shown (see all 217)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455884011,2
    --40847604(+) CTATTC/TCTTCC 1 -- int10--------
    rs1488708331,2
    --40847612(+) TCCTAA/CTTGAT 1 -- int10--------
    rs1888269481,2
    --40847633(+) ATGCTC/TCTTGA 1 -- int10--------
    rs1159087521,2
    C,F--40847699(+) TTATGA/GAGATT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs169774351,2
    C,F--40847719(+) GGTGTA/GTTAAA 1 -- int15Minor allele frequency- G:0.21NA EA 382
    rs169774381,2
    C,F,H--40847762(+) CCTATA/GCAAGG 1 -- int111Minor allele frequency- G:0.06NA NS EA WA CSA 685
    rs1820280531,2
    --40847803(+) CAGCAA/GTAAGA 1 -- int10--------
    rs177217151,2
    C,F,H--40847908(+) CAAACA/CTCATA 1 -- ut31 ese314Minor allele frequency- C:0.01NA NS EA 1244
    rs2021262631,2
    C--40847925(-) CTTTTG/TTGCCA 1 -- ut310--------
    rs1869044971,2
    --40848055(+) GTGGTA/GAGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT4 (40847843 - 40857615 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SYT4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT4
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600103    OMIM disorders: --

    4 diseases for SYT4:    About MalaCards
    pheochromocytoma    parkinson's disease    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SYT4:
    Bipolar disorder

    SYT4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SYT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 30.5 2 15079862 (1)

    Genetic Association Database (GAD): SYT4
    Human Genome Epidemiology (HuGE) Navigator: SYT4 (1 document)

    Export disorders for SYT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT4 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SYT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. (PubMed id 10938284)1, 2, 9 Ferguson G.D.... Herschman H.R. (2000)
    2. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. A third synaptotagmin gene, Syt3, in the mouse. (PubMed id 8058779)1, 3 Hilbush B.S. and Morgan J.I. (1994)
    6. Functional properties of multiple synaptotagmins in brain. (PubMed id 7993622)1, 9 Ullrich B....Sudhof T.C. (1994)
    7. Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (2011)
    8. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. (PubMed id 21315262)1 Zhang G....Cai D. (2011)
    9. Genome-wide association study of major depressive dis order: new results, meta-analysis, and lessons learned. (PubMed id 21042317)4 Wray N.R....Sullivan P.F. (2010)
    10. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PubMed id 17068223)4 Duerr R.H.... Cho J.H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6860 HGNC: 11512 AceView: SYT4 Ensembl:ENSG00000132872 euGenes: HUgn6860
    ECgene: SYT4 H-InvDB: SYT4

    (According to HUGE)
    About This Section
    HUGE: KIAA1342

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYT4 gene:
    Search GeneIP for patents involving SYT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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