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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT4 Gene

protein-coding   GIFtS: 54
GCID: GC18M040847

synaptotagmin IV
 Explore 3 diseases affiliated with
SYT4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SYT4    

Aliases
for SYT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptotagmin IV1 2 3     Synaptotagmin-41
HsT11921 2     SytIV3
KIAA13421 3     SytIV3
Synaptotagmin 42     

External Ids:    HGNC: 115121   Entrez Gene: 68602   Ensembl: ENSG000001328727   OMIM: 6001035   UniProtKB: Q9H2B23   

Export aliases for SYT4 gene to outside databases

Previous GC identifers: GC18M041053 GC18M040634 GC18M040735 GC18M039099 GC18M039101 GC18M037706


Summaries
for SYT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding
to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

Gene Wiki entry for SYT4


Genomic Views
for SYT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT4 gene promoter:
         CREB   AML1a   FOXJ2 (long isoform)   FOXJ2   CUTL1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.3

SYT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M040847:  view genomic region     (about GC identifiers)

Start:
 40,847,857 bp from pter      End:
 40,857,615 bp from pter
Size:
 9,759 bases      Orientation:
 minus strand

Proteins
for SYT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2 (See protein sequence)
Recommended Name: Synaptotagmin-4  
Size: 425 amino acids; 47958 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein
Sequence caution: Sequence=BAA92580.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SYT4:
1UGK (3D)    
Secondary accessions: Q9P2K4

Explore the universe of human proteins at neXtProt for SYT4: NX_Q9H2B2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2B2

    • SYT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065834.1  
    ENSEMBL proteins: 
     ENSP00000255224   ENSP00000466930  

    Human Recombinant Protein Products: 
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    Novus Biologicals SYT4 Protein
    Novus Biologicals SYT4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SYT4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--
    GO:0043005neuron projection IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    SYT4 for ontologies           About GeneDecksing



    SYT4 Antibody Products: 
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    Uscn Antibodies for SYT4
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    Uscn ELISAs and CLIAs for SYT4

    Protein Domains /
    Families
    for SYT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SYT4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9H2B2

    ProtoNet protein and cluster: Q9H2B2

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Function
    for SYT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding
    to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT4
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT4 (see all 78):
    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: SYT4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT4 (see all 6)
    OriGene siRNA: SYT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYT4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SYT4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT4 

    Cell Line
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    Search LifeMap BioReagents cell lines for SYT4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0030276clathrin binding IEA--


    SYT4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Syt4tm1Hahe for SYT4
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Syt4):
     behavior/neurological 

    SYT4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SYT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/14 Interacting proteins for SYT4 (Q9H2B22, 3 ENSP000002552244) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGTAO437652, 3, ENSP000002215664MINT-68022 I2D: score=5 STRING: ENSP00000221566
    STX2P328563, ENSP000003425544I2D: score=1 STRING: ENSP00000342554
    STX4Q128463, ENSP000003177144I2D: score=1 STRING: ENSP00000317714
    TFAP2BQ924813, ENSP000003772654I2D: score=1 STRING: ENSP00000377265
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007269neurotransmitter secretion IEA--


    SYT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SYT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYT4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT4

    1 HMDB Compound for SYT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    7 Novoseek chemical compound relationships for SYT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 37.7 1 15496596 (1)
    aspartate 37.3 5 15079862 (2), 9162066 (1), 10466723 (1)
    calcium 29.3 19 8626542 (5), 9162066 (2), 18046461 (2), 10466723 (2) (see all 7)
    serine 26.6 6 9162066 (2), 15079862 (2), 10466723 (1)
    phospholipid 14.3 5 8626542 (3), 9162066 (1)
    glutamate 0.298 1 15197251 (1)
    lipid 0 2 10466723 (1)

    Search CenterWatch for drugs/clinical trials and news about SYT4 

    Transcripts
    for SYT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SYT4 gene: 
    NM_020783.3  

    Unigene Cluster for SYT4:

    Synaptotagmin IV
    Hs.8059  [show with all ESTs]
    Unigene Representative Sequence: NM_020783
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255224(uc010dng.3 uc002law.3 uc010xcm.2) ENST00000586678
    ENST00000590752 ENST00000585604 ENST00000589479 ENST00000591820

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SYT4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT4
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT4 (see all 78):
    hsa-miR-548j hsa-miR-376b hsa-miR-15a hsa-miR-411 hsa-miR-485-3p hsa-miR-200a hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmid: SYT4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT4 (see all 6)
    OriGene siRNA: SYT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYT4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYT4
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    GenScript: all cDNA clones in your preferred vector: SYT4 (NM_020783)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT4 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYT4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT4

    Additional cDNA sequence: 

    AB037763.1 AF299075.1 AK291154.1 AK293791.1 AK297275.1 AK297379.1 AK299593.1 AK299652.1 
    AK309381.1 AK311335.1 AK311469.1 BC036538.2 

    4 DOTS entries:

    DT.448911  DT.121085608  DT.121085611  DT.91900098 

    24/111 AceView cDNA sequences (see all 111):

    AI339352 AB037763 T33624 Z39631 BC036538 AI306404 AA634047 AI912792 
    T34746 AA084868 BU735881 AA054193 AA907386 AI370743 NM_020783 BQ879623 
    BX478345 Z43564 BM697728 AA363845 BX478664 AA976133 BP361788 T34860 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SYT4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                                  -                           
    SP2:                    -     -     -     -     -     -                           
    SP3:                    -                                                         
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for SYT4

    Expression
    for SYT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAATTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SYT4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See SYT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT4

    SOURCE GeneReport for Unigene cluster: Hs.8059

    UniProtKB/Swiss-Prot: SYT4_HUMAN, Q9H2B2
    Tissue specificity: Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels
    also detected in amygdala and thalamus

        SABiosciences Custom PCR Arrays for SYT4
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT4

    Orthologs
    for SYT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SYT4 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SYT41 synaptotagmin IV 80.94(n)
    88(a)    		   422960  XM_420894.3  XP_420894.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SYT46
    		 --
    		 86(a)
    		 1 ↔ 1
    		 1(36413684-36429340)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.90432 Transcribed sequence with moderate similarity to protein more 76.64(n)    CF783621.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj05d112 wufj05d11 75.15(n)   335357  BC059580.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SytIV3 synaptic vesicle exocytosis
    calcium-dependent more    		 49(a)   84D3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T23H2.23 C2 domain protein 38(a)   I(6444216-6448962)   --


    ENSEMBL Gene Tree for SYT4 (if available)
    TreeFam Gene Tree for SYT4 (if available) 

    Paralogs
    for SYT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT4 gene
    SYT152  SYT52  SYT82  SYT92  SYT32  SYT102  SYT62  SYT172  
    SYT112  SYT22  SYT122  SYT72  SYT12  
    14 SIMAP similar genes for SYT4 using alignment to 4 protein entries:     SYT4_HUMAN (see all proteins):
    SYT11    SYT5    SYT1    SYT2    SYT6    SYT9
    SYT10    SYT7    DKFZp434D2429    SYT3    SYT17    RPH3A
    CHR11SYT    DOC2B

    SYT4 for paralogs           About GeneDecksing



    Genomic Variants
    for SYT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 NCBI SNPs in SYT4 are shown (see all 172)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1455884011,2
    		--40847604(+) CTATTC/TCTTCC 1 -- int10--------
    rs1488708331,2
    		--40847612(+) TCCTAA/CTTGAT 1 -- int10--------
    rs1888269481,2
    		--40847633(+) ATGCTC/TCTTGA 1 -- int10--------
    rs1159087521,2
    		--40847699(+) TTATGA/GAGATT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs169774351,2
    		C,F,--40847719(+) GGTGTA/GTTAAA 1 -- int15Minor allele frequency- G:0.21NA EA 382
    rs169774381,2
    		C,F,H,--40847762(+) CCTATA/GCAAGG 1 -- int111Minor allele frequency- G:0.06NA NS EA WA CSA 685
    rs1820280531,2
    		--40847803(+) CAGCAA/GTAAGA 1 -- int10--------
    rs177217151,2
    		C,F,H,--40847908(+) CAAACA/CTCATA 1 -- ut31 ese314Minor allele frequency- C:0.01NA NS EA 1244
    rs2021262631,2
    		C--40847925(-) CTTTTG/TTGCCA 1 -- ut310--------
    rs1869044971,2
    		--40848055(+) GTGGTA/GAGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT4 (40847857 - 40857615 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SYT4: --

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    Disorders / Diseases
    for SYT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SYT4 for disorders           About GeneDecksing

    OMIM gene information: 600103    OMIM disorders: --

    3 diseases for SYT4:    About MalaCards
    pheochromocytoma    parkinson's disease    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for SYT4:
    Bipolar disorder

    1 Novoseek disease relationship for SYT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 30.5 2 15079862 (1)

    Human Genome Epidemiology (HuGE) Navigator: SYT4 (1 document)

    Export disorders for SYT4 gene to outside databases

    Publications
    for SYT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT4 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SYT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. (PubMed id 10938284)1, 2, 9 Ferguson G.D.... Herschman H.R. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    4. A third synaptotagmin gene, Syt3, in the mouse. (PubMed id 8058779)1, 3 Hilbush B.S. and Morgan J.I. (1994)
    5. Functional properties of multiple synaptotagmins in brain. (PubMed id 7993622)1, 9 Ullrich B....Sudhof T.C. (1994)
    6. Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (2011)
    7. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. (PubMed id 21315262)1 Zhang G....Cai D. (2011)
    8. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SYT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SYT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6860 HGNC: 11512 AceView: SYT4 Ensembl:ENSG00000132872 euGenes: HUgn6860
    ECgene: SYT4 H-InvDB: SYT4

    Other Databases showing SYT4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1342

    Specialized Databases showing SYT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SYT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SYT4 gene:
    Search GeneIP for patents involving SYT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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