Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYT3 Gene

Aliases for SYT3 Gene

  • Synaptotagmin 3 2 3 5
  • Synaptotagmin III 2 3 4
  • SytIII 3 4
  • Synaptotagmin-3 3

External Ids for SYT3 Gene

Previous GeneCards Identifiers for SYT3 Gene

  • GC19U990091
  • GC19M051486
  • GC19M055801
  • GC19M055817
  • GC19M051125
  • GC19M047460

Summaries for SYT3 Gene

GeneCards Summary for SYT3 Gene

SYT3 (Synaptotagmin 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT9.

UniProtKB/Swiss-Prot for SYT3 Gene

  • Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for SYT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT3 Gene

Genomics for SYT3 Gene

Regulatory Elements for SYT3 Gene

Enhancers for SYT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYT3 on UCSC Golden Path with GeneCards custom track

Promoters for SYT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT3 Gene

Chromosome:
19
Start:
50,621,307 bp from pter
End:
50,658,127 bp from pter
Size:
36,821 bases
Orientation:
Minus strand

Genomic View for SYT3 Gene

Genes around SYT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT3 Gene

Proteins for SYT3 Gene

  • Protein details for SYT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQG1-SYT3_HUMAN
    Recommended name:
    Synaptotagmin-3
    Protein Accession:
    Q9BQG1
    Secondary Accessions:
    • Q8N5Z1
    • Q8N640

    Protein attributes for SYT3 Gene

    Size:
    590 amino acids
    Molecular mass:
    63304 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT6, SYT9 and SYT10.

neXtProt entry for SYT3 Gene

Post-translational modifications for SYT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT3 Gene

No data available for DME Specific Peptides for SYT3 Gene

Domains & Families for SYT3 Gene

Gene Families for SYT3 Gene

Protein Domains for SYT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQG1

UniProtKB/Swiss-Prot:

SYT3_HUMAN :
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
Domain:
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT3: view

Function for SYT3 Gene

Molecular function for SYT3 Gene

GENATLAS Biochemistry:
synaptotagmin 3,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function:
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology (GO) - Molecular Function for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005509 calcium ion binding IBA --
GO:0005544 calcium-dependent phospholipid binding NAS 12526776
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT3: view
genes like me logo Genes that share phenotypes with SYT3: view

Animal Models for SYT3 Gene

MGI Knock Outs for SYT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYT3

CRISPR Products

miRNA for SYT3 Gene

miRTarBase miRNAs that target SYT3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT3 Gene

Localization for SYT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT3 Gene

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT3 Gene COMPARTMENTS Subcellular localization image for SYT3 gene
Compartment Confidence
endosome 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030658 transport vesicle membrane IEA --
GO:0070382 exocytic vesicle IBA --
genes like me logo Genes that share ontologies with SYT3: view

Pathways & Interactions for SYT3 Gene

SuperPathways for SYT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0031340 positive regulation of vesicle fusion IEA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
GO:0051592 response to calcium ion IEA --
genes like me logo Genes that share ontologies with SYT3: view

No data available for Pathways by source and SIGNOR curated interactions for SYT3 Gene

Drugs & Compounds for SYT3 Gene

(2) Drugs for SYT3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SYT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYT3: view

Transcripts for SYT3 Gene

Unigene Clusters for SYT3 Gene

Synaptotagmin III:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT3 Gene

No ASD Table

Relevant External Links for SYT3 Gene

GeneLoc Exon Structure for
SYT3
ECgene alternative splicing isoforms for
SYT3

Expression for SYT3 Gene

mRNA expression in normal human tissues for SYT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT3 Gene

This gene is overexpressed in Brain - Cortex (x6.0), Brain - Frontal Cortex (BA9) (x5.6), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Cerebellum (x4.8), Brain - Hippocampus (x4.6), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for SYT3 Gene

This gene is overexpressed in Frontal cortex (27.9), Fetal Brain (21.1), and Retina (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT3 Gene



Protein tissue co-expression partners for SYT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYT3 Gene:

SYT3

SOURCE GeneReport for Unigene cluster for SYT3 Gene:

Hs.515554

mRNA Expression by UniProt/SwissProt for SYT3 Gene:

Q9BQG1-SYT3_HUMAN
Tissue specificity: Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with SYT3: view

Primer Products

Orthologs for SYT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT3 34
  • 92.49 (n)
  • 98.14 (a)
SYT3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT3 34
  • 92.6 (n)
  • 97.8 (a)
SYT3 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt3 34
  • 87.75 (n)
  • 95.56 (a)
Syt3 16
Syt3 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT3 34
  • 99.38 (n)
  • 99.15 (a)
SYT3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt3 34
  • 88 (n)
  • 95.73 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SYT3 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT3 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt3 34
  • 65.36 (n)
  • 68.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100000615 34
  • 65.55 (n)
  • 65.79 (a)
syt3 35
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syt1 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-1 35
  • 35 (a)
ManyToMany
snt-2 35
  • 37 (a)
ManyToMany
snt-3 35
  • 44 (a)
ManyToMany
Species where no ortholog for SYT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT3 Gene

ENSEMBL:
Gene Tree for SYT3 (if available)
TreeFam:
Gene Tree for SYT3 (if available)

Paralogs for SYT3 Gene

Paralogs for SYT3 Gene

(8) SIMAP similar genes for SYT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYT3: view

Variants for SYT3 Gene

Sequence variations from dbSNP and Humsavar for SYT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036389 A breast cancer sample
rs10426057 -- 50,625,599(+) GACTC(A/C)CTCCC intron-variant
rs3956158 -- 50,622,228(+) GGGGC(A/C/G/T)ATGCA utr-variant-3-prime
rs17849188 -- 50,630,260(-) GGGGG(A/G)AAGGC intron-variant
rs17849190 -- 50,629,611(-) ACTCC(C/T)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT3 Gene

Variant ID Type Subtype PubMed ID
dgv1800n106 CNV deletion 24896259
esv1000559 CNV deletion 20482838
esv1217472 CNV insertion 17803354
esv1394478 CNV deletion 17803354
esv1959087 CNV deletion 18987734
esv2718743 CNV deletion 23290073
esv32592 CNV gain 17666407
esv33599 CNV loss 17666407
esv3574587 CNV gain 25503493
nsv1065222 CNV loss 25217958
nsv1140251 OTHER inversion 24896259
nsv1148092 CNV deletion 26484159
nsv828582 CNV loss 20364138
nsv828583 CNV loss 20364138
nsv828584 CNV loss 20364138
nsv961234 CNV duplication 23825009

Variation tolerance for SYT3 Gene

Residual Variation Intolerance Score: 6.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT3 Gene

Disorders for SYT3 Gene

Relevant External Links for SYT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT3

No disorders were found for SYT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT3 Gene

Publications for SYT3 Gene

  1. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo J.C. … Yoon T.J. (J. Dermatol. Sci. 2013) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 65
  4. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PMID: 7749232) Jones J.M. … Meisler M.H. (Mamm. Genome 1995) 2 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for SYT3 Gene

Sources for SYT3 Gene

Content