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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYT3 Gene

protein-coding GIFtS: 49
GCID: GC19M051125

synaptotagmin III

Explore 3 diseases affiliated with
SYT3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin III¹ ² ³
SytIII² ³
Synaptotagmin-3¹

External Ids:	HGNC: 11511¹	Entrez Gene: 84258²	Ensembl: ENSG00000213023⁷	OMIM: 600327⁵	UniProtKB: Q9BQG1³

Export aliases for SYT3 gene to outside databases

Previous GC identifers: GC19U990091 GC19M051486 GC19M055801 GC19M055817 GC19M047460

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

Gene Wiki entry for SYT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYT3 gene promoter:
ER-alpha NF-1/L NF-1 Tal-1beta C/EBPalpha E47 RORalpha1 MZF-1 ZIC2/Zic2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT3 promoter sequence

Search SABiosciences Chromatin IP Primers for SYT3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.41

SYT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M051125: view genomic region (about GC identifiers)

Start:	51,125,234 bp from pter	End:	51,171,651 bp from pter
Size:	46,418 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1 (See protein sequence)

Recommended Name: Synaptotagmin-3

Size: 590 amino acids; 63304 Da

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)

Subunit: Homodimer. Can also form heterodimers with SYT6 (By similarity)

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein

(By similarity)

Secondary accessions: Q8N5Z1 Q8N640

Explore the universe of human proteins at neXtProt for SYT3: NX_Q9BQG1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BQG1

SYT3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001153800.1 NP_001153801.1 NP_115674.1

ENSEMBL proteins:

ENSP00000438883 ENSP00000340914

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): SYT3 OriGene Protein Over-expression Lysate (see all 3): SYT3 OriGene Custom Protein Services for SYT3
	GenScript Custom Purified and Recombinant Proteins Services for SYT3
	Novus Biologicals SYT3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYT3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005768	endosome	IDA	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0030672	synaptic vesicle membrane	IEA	--

SYT3 for ontologies About GeneDecksing

SYT3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SYT3
	Browse R&D Systems for Antibodies
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	GenScript Custom Superior Antibodies Services for SYT3
	Novus Biologicals SYT3 Antibodies
	Search for Antibodies for SYT3 at Abcam
	Uscn Antibodies for SYT3
	Search ThermoFisher Antibodies for SYT3

Assay Products for SYT3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYT3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYT3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYT3 for domains About GeneDecksing

5 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001565 Synaptotagmin

IPR018029 C2_membr_targeting

IPR020477 C2_dom

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q9BQG1

ProtoNet protein and cluster: Q9BQG1

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1

Domain: The first C2 domain mediates Ca(2+)-dependent phospholipid binding

Similarity: Belongs to the synaptotagmin family

Similarity: Contains 2 C2 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

Genatlas biochemistry entry for SYT3:

synaptotagmin 3,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in

exocytosis and endocytosis

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SYT3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT3
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT3 (see all 24):
		hsa-miR-4311 hsa-miR-3917 hsa-miR-181c hsa-miR-15a hsa-miR-503 hsa-miR-424 hsa-miR-195 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: SYT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT3 (see all 7) OriGene shRNA RFP: SYT3 OriGene siRNA: SYT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYT3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SYT3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYT3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYT3 (NM_031913)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYT3
		Search LifeMap BioReagents cell lines for SYT3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005544	calcium-dependent phospholipid binding	IEA	--
GO:0019905	syntaxin binding	IEA	--
GO:0030276	clathrin binding	IEA	--

SYT3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Syt3^tm1Sud for SYT3
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Syt3):

normal

SYT3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYT3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/8 Interacting proteins for SYT3 (Q9BQG1³ ENSP00000340914⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SYT5	O00445³, ENSP00000346265⁴	I2D: score=1 STRING: ENSP00000346265
SNAP25	P60880³, ENSP00000254976⁴	I2D: score=2 STRING: ENSP00000254976
SYNCRIP	O60506³, ENSP00000358635⁴	I2D: score=2 STRING: ENSP00000358635
AP2A1	O95782³, ENSP00000351926⁴	I2D: score=1 STRING: ENSP00000351926
CACNA1B	Q00975³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SYT3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYT3

1 HMDB Compound for SYT3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 Novoseek chemical compound relationships for SYT3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol	40.3	1	10358928 (1)
phospholipid	20.2	3	9163333 (3)
calcium	16.9	2	9830048 (1)

Search CenterWatch for drugs/clinical trials and news about SYT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYT3 gene (3 alternative transcripts):

NM_001160328.1 NM_001160329.1 NM_032298.2

Unigene Cluster for SYT3:

Synaptotagmin III

Hs.515554 [show with all ESTs]

Unigene Representative Sequence: AL136594

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000544769(uc002psv.3 uc010ycd.2) ENST00000338916(uc002pst.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SYT3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT3
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT3 (see all 24):
		hsa-miR-4311 hsa-miR-3917 hsa-miR-181c hsa-miR-15a hsa-miR-503 hsa-miR-424 hsa-miR-195 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: SYT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT3 (see all 7) OriGene shRNA RFP: SYT3 OriGene siRNA: SYT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYT3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYT3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYT3 (NM_031913)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYT3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYT3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT3

Additional cDNA sequence:

AL136594.1 BC028379.1 BC031067.1

5 DOTS entries:

DT.40114794 DT.100021968 DT.95157972 DT.121414988 DT.92033316

24/25 AceView cDNA sequences (see all 25):

AA594745 AW451023 BF593902 BU176847 BM710834 BM667671 AL136594 F08666

NM_032298 BC028379 BX283781 Z41650 BF307829 BC031067 BE220745 BU726788

BI916739 BI550777 BG702285 BI912995 BM688060 CK004629 BI522420 BG704063

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGGGGGAC

About this image

SYT3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Extraocular Muscles

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYT3

SOURCE GeneReport for Unigene cluster: Hs.515554

SABiosciences Custom PCR Arrays for SYT3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYT3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYT3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYT3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SYT3⁶	--	70(a)	1 ↔ 1	6(79535799-79566876)
zebrafish (Danio rerio)	Actinopterygii	syt3⁶	synaptotagmin III	64(a)	1 ↔ 1	3(30666484-30776338)
fruit fly (Drosophila melanogaster)	Insecta	Sytbeta⁶	Synaptotagmin beta	19(a)	possible ortholog	3L(15007795-15058077)
worm (Caenorhabditis elegans)	Secernentea	snt-6⁶	SyNapTotagmin family member (snt-6)	31(a)	possible ortholog	II(745469-750171)

ENSEMBL Gene Tree for SYT3 (if available)
TreeFam Gene Tree for SYT3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYT3 gene

SYT15² SYT4² SYT5² SYT8² SYT9² SYT10² SYT6² SYT17²

SYT11² SYT2² SYT12² SYT7² SYT1²

8 SIMAP similar genes for SYT3 using alignment to 3 protein entries: SYT3_HUMAN (see all proteins):

SYT1 SYT10 SYT2 SYT5 SYT6 SYT9

SYT7 SYT4

SYT3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117657113^1,2		--	51124750(+)	`AGACCG/AGCCTG`	3	--	int¹		1		NA	120
rs11672283^1,2	C,H,	--	51124774(+)	`accccA/Gtctct`	3	--	int¹		0	--	--	--	--
rs113560962^1,2	C,	--	51124806(+)	`CCAGGC/TGTGGT`	3	--	int¹		1		WA	2
rs149364415^1,2		--	51124809(+)	`GGCGTG/TGTGGC`	3	--	int¹		0	--	--	--	--
rs144689285^1,2		--	51124818(+)	`GCGAGC/TGGCTG`	3	--	int¹		0	--	--	--	--
rs3956158^1,2	C	--	51125485(-)	`GGGGCC/AATGCA`	3	--	ut3¹		1		NA	2
rs186522177^1,2		--	51125546(+)	`GAATGA/CCCCCC`	3	--	ut3¹		0	--	--	--	--
rs118078846^1,2	F,	--	51125896(+)	`TCAGAC/TGCAGG`	3	--	int¹		1		NA	120
rs201686278^1,2		--	51125939(+)	`GGCTGC/TTTACC`	3	--	int¹		0	--	--	--	--
rs139672852^1,2	C,F,	--	51125953(+)	`CACTCG/AGAGTT`	6	/S	syn¹		2		NA EU	5291

HapMap Linkage Disequilibrium report for SYT3 (51125234 - 51171651 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SYT3
2 CNVs: 7212 7213

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT3

DNA2.0 Custom Variant and Variant Library Synthesis for SYT3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYT3 for disorders           About GeneDecksing

OMIM gene information: 600327    OMIM disorders: --

3 diseases for SYT3:    About MalaCards

seizures pancreatitis neuronitis

Export disorders for SYT3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYT3 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with SYT3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PubMed id 7749232)^{1, 3} Jones J.M....Meisler M.H. (1995)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Genomic analysis of synaptotagmin genes. (PubMed id 11543631)¹ Craxton M.A. (2001)
SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. (PubMed id 10734137)¹ Mizutani A....Mikoshiba K. (2000)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84258	HGNC: 11511	AceView: SYT3	Ensembl:ENSG00000213023	euGenes: HUgn84258
ECgene: SYT3	H-InvDB: SYT3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYT3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYT3 gene:
Search GeneIP for patents involving SYT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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	Browse OriGene Antibodies		OriGene shRNA RFP for SYT3
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYT3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT3
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	GenScript Custom Purified and Recombinant Proteins Services for SYT3		GenScript cDNA clones with any tag delivered in your preferred vector for SYT3
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	GenScript Custom overexpressing Cell Line Services for SYT3		CloneReady with Over 120,000 Genes
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT3

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYT3 gene at Home site.

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SYT3 Gene

synaptotagmin III

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SYT3 Gene

synaptotagmin III

Aliasesfor SYT3 gene

Summariesfor SYT3 gene

Genomic Viewsfor SYT3 gene

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Protein Domains /Familiesfor SYT3 gene

Functionfor SYT3 gene

Pathways & Interactionsfor SYT3 gene

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Other Databases showing SYT3 gene

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for SYT3 gene

Summaries
for SYT3 gene

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for SYT3 gene

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for SYT3 gene

Protein Domains /
Families
for SYT3 gene

Function
for SYT3 gene

Pathways & Interactions
for SYT3 gene

Drugs & Compounds
for SYT3 gene

Transcripts
for SYT3 gene

Expression
for SYT3 gene

Orthologs
for SYT3 gene

Paralogs
for SYT3 gene

Genomic Variants
for SYT3 gene

Disorders / Diseases
for SYT3 gene

Publications
for SYT3 gene

Intellectual Property
for SYT3 gene

Products
for SYT3 gene