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Aliases for SYT3 Gene

Aliases for SYT3 Gene

  • Synaptotagmin III 2 3 4
  • SytIII 3 4
  • Synaptotagmin-3 3

External Ids for SYT3 Gene

Previous GeneCards Identifiers for SYT3 Gene

  • GC19U990091
  • GC19M051486
  • GC19M055801
  • GC19M055817
  • GC19M051125
  • GC19M047460

Summaries for SYT3 Gene

GeneCards Summary for SYT3 Gene

SYT3 (Synaptotagmin III) is a Protein Coding gene. GO annotations related to this gene include transporter activity and syntaxin binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT3 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT3 Gene

Genomics for SYT3 Gene

Regulatory Elements for SYT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYT3 Gene

Start:
50,621,307 bp from pter
End:
50,668,394 bp from pter
Size:
47,088 bases
Orientation:
Minus strand

Genomic View for SYT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT3 Gene

Proteins for SYT3 Gene

  • Protein details for SYT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQG1-SYT3_HUMAN
    Recommended name:
    Synaptotagmin-3
    Protein Accession:
    Q9BQG1
    Secondary Accessions:
    • Q8N5Z1
    • Q8N640

    Protein attributes for SYT3 Gene

    Size:
    590 amino acids
    Molecular mass:
    63304 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer. Can also form heterodimers with SYT6 (By similarity).

neXtProt entry for SYT3 Gene

Proteomics data for SYT3 Gene at MOPED

Post-translational modifications for SYT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT3 Gene

Domains for SYT3 Gene

Gene Families for SYT3 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQG1

UniProtKB/Swiss-Prot:

SYT3_HUMAN :
  • Q9BQG1
Domain:
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT3: view

Function for SYT3 Gene

Molecular function for SYT3 Gene

GENATLAS Biochemistry: synaptotagmin 3,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0001786 phosphatidylserine binding IEA --
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SYT3: view

Phenotypes for SYT3 Gene

MGI mutant phenotypes for SYT3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SYT3: view

Animal Models for SYT3 Gene

MGI Knock Outs for SYT3:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYT3 Gene

Localization for SYT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT3 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT3 Gene COMPARTMENTS Subcellular localization image for SYT3 gene
Compartment Confidence
endosome 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SYT3: view

Pathways for SYT3 Gene

SuperPathways for SYT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017156 calcium ion-dependent exocytosis IEA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0031340 positive regulation of vesicle fusion IEA --
genes like me logo Genes that share ontologies with SYT3: view

No data available for Pathways by source for SYT3 Gene

Compounds for SYT3 Gene

(1) HMDB Compounds for SYT3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for SYT3 Gene

Compound -log(P) Hits PubMed IDs
inositol 40.3 1
phospholipid 20.2 3
calcium 16.9 1
genes like me logo Genes that share compounds with SYT3: view

Transcripts for SYT3 Gene

Unigene Clusters for SYT3 Gene

Synaptotagmin III:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT3 Gene

No ASD Table

Relevant External Links for SYT3 Gene

GeneLoc Exon Structure for
SYT3
ECgene alternative splicing isoforms for
SYT3

Expression for SYT3 Gene

mRNA expression in normal human tissues for SYT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT3 Gene

This gene is overexpressed in Brain - Cortex (6.0), Brain - Frontal Cortex (BA9) (5.6), Brain - Anterior cingulate cortex (BA24) (4.9), Brain - Cerebellum (4.8), Brain - Hippocampus (4.6), and Brain - Cerebellar Hemisphere (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT3 Gene

SOURCE GeneReport for Unigene cluster for SYT3 Gene Hs.515554

genes like me logo Genes that share expressions with SYT3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYT3 Gene

Orthologs for SYT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT3 35
  • 99.38 (n)
  • 99.15 (a)
SYT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT3 35
  • 92.49 (n)
  • 98.14 (a)
SYT3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT3 35
  • 92.6 (n)
  • 97.8 (a)
SYT3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt3 35
  • 87.75 (n)
  • 95.56 (a)
Syt3 16
Syt3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT3 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt3 35
  • 88 (n)
  • 95.73 (a)
lizard
(Anolis carolinensis)
Reptilia SYT3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt3 35
  • 65.36 (n)
  • 68.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100000615 35
  • 65.55 (n)
  • 65.79 (a)
syt3 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syt1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-1 36
  • 35 (a)
ManyToMany
snt-2 36
  • 37 (a)
ManyToMany
snt-3 36
  • 44 (a)
ManyToMany
Species with no ortholog for SYT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT3 Gene

ENSEMBL:
Gene Tree for SYT3 (if available)
TreeFam:
Gene Tree for SYT3 (if available)

Paralogs for SYT3 Gene

Paralogs for SYT3 Gene

Selected SIMAP similar genes for SYT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYT3: view

Variants for SYT3 Gene

Sequence variations from dbSNP and Humsavar for SYT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1862480 -- 50,626,562(+) acaga(A/G)gccca intron-variant
rs1862481 -- 50,626,662(+) ccaga(C/G)agaga intron-variant
rs2059146 -- 50,626,506(+) agagg(G/T)ggggg intron-variant
rs3956158 -- 50,622,228(-) GGGGC(A/C)ATGCA utr-variant-3-prime
rs4239490 -- 50,628,799(+) AGGAA(C/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT3 Gene

Variant ID Type Subtype PubMed ID
esv33599 CNV Loss 17666407
esv2718743 CNV Deletion 23290073
esv1959087 CNV Deletion 18987734
esv1000559 CNV Deletion 20482838
esv1394478 CNV Deletion 17803354
esv32592 CNV Gain 17666407
esv1217472 CNV Insertion 17803354
nsv828582 CNV Loss 20364138
nsv828583 CNV Loss 20364138
nsv912285 CNV Loss 21882294
nsv828584 CNV Loss 20364138

Relevant External Links for SYT3 Gene

HapMap Linkage Disequilibrium report
SYT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT3 Gene

Disorders for SYT3 Gene

No disorders were found for SYT3 Gene.

No data available for UniProtKB/Swiss-Prot for SYT3 Gene

Publications for SYT3 Gene

  1. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PMID: 7749232) Jones J.M. … Meisler M.H. (Mamm. Genome 1995) 2 3
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for SYT3 Gene

Sources for SYT3 Gene

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