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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT3 Gene

protein-coding   GIFtS: 52
GCID: GC19M051125

Synaptotagmin III

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin III1 2 3
SytIII2 3
synaptotagmin-32

External Ids:    HGNC: 115111   Entrez Gene: 842582   Ensembl: ENSG000002130237   OMIM: 6003275   UniProtKB: Q9BQG13   

Export aliases for SYT3 gene to outside databases

Previous GC identifers: GC19U990091 GC19M051486 GC19M055801 GC19M055817 GC19M047460


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYT3 Gene: 
SYT3 (synaptotagmin III) is a protein-coding gene. Diseases associated with SYT3 include pancreatitis, and neuronitis. GO annotations related to this gene include transporter activity and syntaxin binding. An important paralog of this gene is DOC2B.

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
(By similarity)

Gene Wiki entry for SYT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT3 gene promoter:
         ER-alpha   NF-1/L   NF-1   Tal-1beta   C/EBPalpha   E47   RORalpha1   MZF-1   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.41

SYT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051125:  view genomic region     (about GC identifiers)

Start:
51,124,564 bp from pter      End:
51,171,651 bp from pter
Size:
47,088 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1 (See protein sequence)
Recommended Name: Synaptotagmin-3  
Size: 590 amino acids; 63304 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer. Can also form heterodimers with SYT6 (By similarity)
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
protein (By similarity)
Secondary accessions: Q8N5Z1 Q8N640

Explore the universe of human proteins at neXtProt for SYT3: NX_Q9BQG1

Explore proteomics data for SYT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQG1

  • SYT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYT3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001153800.1  NP_001153801.1  NP_115674.1  

    ENSEMBL proteins: 
     ENSP00000469834   ENSP00000340914   ENSP00000469398   ENSP00000468982   ENSP00000469637  
     ENSP00000438883  

    Human Recombinant Protein Products for SYT3: 
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    Cloud-Clone Corp. Proteins for SYT3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    SYT3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SYT: Synaptotagmins

    5 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR020477 C2_dom
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9BQG1

    ProtoNet protein and cluster: Q9BQG1

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT3_HUMAN, Q9BQG1
    Domain: The first C2 domain mediates Ca(2+)-dependent phospholipid binding
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT3_HUMAN, Q9BQG1
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
    (By similarity)

         Genatlas biochemistry entry for SYT3:
    synaptotagmin 3,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved
    in exocytosis and endocytosis

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005544calcium-dependent phospholipid binding IEA--
    GO:0019905syntaxin binding IEA--
    GO:0030276clathrin binding IEA--
         
    SYT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Syt3):
     normal 

    SYT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Syt3tm1Sud for SYT3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYT3 
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    hsa-miR-4311 hsa-miR-3917 hsa-miR-181c hsa-miR-15a hsa-miR-503 hsa-miR-424 hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidSYT3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for SYT3 (Q9BQG13 ENSP000003409144) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYT5O004453, ENSP000003462654I2D: score=1 STRING: ENSP00000346265
    SNAP25P608803, ENSP000002549764I2D: score=2 STRING: ENSP00000254976
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    AP2A1O957823, ENSP000003519264I2D: score=1 STRING: ENSP00000351926
    CACNA1BQ009753I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT3

    1 HMDB Compound for SYT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for SYT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 40.3 1 10358928 (1)
    phospholipid 20.2 3 9163333 (3)
    calcium 16.9 2 9830048 (1)

    Search CenterWatch for drugs/clinical trials and news about SYT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYT3 gene (3 alternative transcripts): 
    NM_001160328.1  NM_001160329.1  NM_032298.2  

    Unigene Cluster for SYT3:

    Synaptotagmin III
    Hs.515554  [show with all ESTs]
    Unigene Representative Sequence: AL136594
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595557 ENST00000338916(uc002pst.3) ENST00000600079 ENST00000593901
    ENST00000595117 ENST00000598997 ENST00000544769(uc002psv.3 uc010ycd.2)

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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT3 (see all 24):
    hsa-miR-4311 hsa-miR-3917 hsa-miR-181c hsa-miR-15a hsa-miR-503 hsa-miR-424 hsa-miR-195 hsa-miR-15b
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    Inhib. RNA
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    Additional mRNA sequence: 

    AL136594.1 BC028379.1 BC031067.1 

    5 DOTS entries:

    DT.40114794  DT.100021968  DT.95157972  DT.121414988  DT.92033316 

    24/25 AceView cDNA sequences (see all 25):

    BC028379 BU176847 BC031067 Z41650 AW451023 AL136594 BF593902 BF307829 
    F08666 BM710834 BM667671 BE220745 NM_032298 BX283781 AA594745 BI916739 
    BU726788 BI550777 BG702285 BI912995 BM688060 BG704063 BI522420 CK004629 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT3 expression in normal human tissues (normalized intensities)      SYT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGGGGAC
    SYT3 Expression
    About this image


    SYT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             postcentral gyrus   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See SYT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT3

    SOURCE GeneReport for Unigene cluster: Hs.515554
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYT3 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt31 , 5 synaptotagmin III1, 5 88.03(n)1
    96.24(a)1
      7 (28.83 cM)5
    209811  NM_001114116.11  NP_001107588.11 
     443841025 
    lizard
    (Anolis carolinensis)
    Reptilia SYT36
    Uncharacterized protein
    67(a)
    1 ↔ 1
    6(79497006-79566900)
    zebrafish
    (Danio rerio)
    Actinopterygii syt36
    synaptotagmin III
    62(a)
    1 ↔ 1
    3(30666484-30776338)
    worm
    (Caenorhabditis elegans)
    Secernentea snt-26
    snt-16
    (see all 3)
    Synaptotagmin-1
    (see all 3)
    35(a)
    34(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(786698-793687)
    II(6810963-6816454)


    ENSEMBL Gene Tree for SYT3 (if available)
    TreeFam Gene Tree for SYT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT3 gene
    DOC2B2  SYT42  SYT52  SYT92  SYT82  SYT102  SYT62  SYT172  
    SYT112  SYT122  SYT22  DOC2A2  SYT72  RPH3A2  SYT12  
    8 SIMAP similar genes for SYT3 using alignment to 3 protein entries:     SYT3_HUMAN (see all proteins):
    SYT9    SYT1    SYT2    SYT10    SYT5    SYT6
    SYT7    SYT4

    SYT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1106 SNPs in SYT3 are shown (see all 1106)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363894
    A breast cancer sample4--see VAR_0363892 S F mis40--------
    rs1176571131,2
    F--51124750(+) AGACCG/AGCCTG 3 -- int11Minor allele frequency- A:0.01NA 120
    rs116722831,2
    C,H--51124774(+) accccA/Gtctct 3 -- int10--------
    rs1135609621,2
    C,F--51124806(+) CCAGGC/TGTGGT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1493644151,2
    C--51124809(+) GGCGTG/TGTGGC 3 -- int10--------
    rs1446892851,2
    --51124818(+) GCGAGC/TGGCTG 3 -- int10--------
    rs3712025081,2
    C--51125250(+) CCCACA/GAGTGT 3 -- ut310--------
    rs39561581,2
    C--51125485(-) GGGGCC/AATGCA 3 -- ut311Minor allele frequency- A:0.00NA 2
    rs1865221771,2
    --51125546(+) GAATGA/CCCCCC 3 -- ut310--------
    rs1180788461,2
    C,F--51125896(+) TCAGAC/TGCAGG 3 -- int11Minor allele frequency- T:0.08NA 120

    HapMap Linkage Disequilibrium report for SYT3 (51124564 - 51171651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SYT3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1959087CNV Deletion18987734
    esv2718743CNV Deletion23290073
    esv1000559CNV Deletion20482838
    esv1394478CNV Deletion17803354
    esv1217472CNV Insertion17803354
    nsv828583CNV Loss20364138
    esv33599CNV Loss17666407
    nsv828582CNV Loss20364138
    nsv828584CNV Loss20364138
    nsv912285CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600327    OMIM disorders: --

    2 diseases for SYT3:    About MalaCards
    pancreatitis    neuronitis


    SYT3 for disorders           About GeneDecksing


    Export disorders for SYT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT3 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SYT3)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    3. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PubMed id 7749232)1, 3 Jones J.M....Meisler M.H. (1995)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    6. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1 Craxton M.A. (2001)
    9. SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. (PubMed id 10734137)1 Mizutani A....Mikoshiba K. (2000)
    10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84258 HGNC: 11511 AceView: SYT3 Ensembl:ENSG00000213023 euGenes: HUgn84258
    ECgene: SYT3 H-InvDB: SYT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYT3 gene:
    Search GeneIP for patents involving SYT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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