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Aliases for SYT2 Gene

Aliases for SYT2 Gene

  • Synaptotagmin II 2 3 4
  • SytII 3 4
  • Synaptotagmin-2 3
  • MYSPC 3

External Ids for SYT2 Gene

Summaries for SYT2 Gene

Entrez Gene Summary for SYT2 Gene

  • This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for SYT2 Gene

SYT2 (Synaptotagmin II) is a Protein Coding gene. Diseases associated with SYT2 include myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy and botulism. Among its related pathways are Disease and Transmission across Chemical Synapses. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT2 Gene

  • May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity).

Gene Wiki entry for SYT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT2 Gene

Genomics for SYT2 Gene

Genomic Location for SYT2 Gene

Start:
202,590,596 bp from pter
End:
202,710,423 bp from pter
Size:
119,828 bases
Orientation:
Minus strand

Genomic View for SYT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT2 Gene

Regulatory Elements for SYT2 Gene

Proteins for SYT2 Gene

  • Protein details for SYT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I0-SYT2_HUMAN
    Recommended name:
    Synaptotagmin-2
    Protein Accession:
    Q8N9I0
    Secondary Accessions:
    • Q496K5
    • Q8NBE5

    Protein attributes for SYT2 Gene

    Size:
    419 amino acids
    Molecular mass:
    46872 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homotetramer (Probable). Interacts with stonin 2 (By similarity). Interacts with SCAMP5.

neXtProt entry for SYT2 Gene

Proteomics data for SYT2 Gene at MOPED

Post-translational modifications for SYT2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn29

Other Protein References for SYT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT2 Gene

Domains for SYT2 Gene

Gene Families for SYT2 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SYT2_HUMAN
Domain:
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.:
    • Q8N9I0
  • The second C2 domain mediates interaction with Stonin 2.:
    • Q8N9I0
  • Contains 2 C2 domains.:
    • Q8N9I0
Family:
  • Belongs to the synaptotagmin family.:
    • Q8N9I0
genes like me logo Genes that share domains with SYT2: view

Function for SYT2 Gene

Molecular function for SYT2 Gene

GENATLAS Biochemistry: synaptotagmin 2,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity).

Gene Ontology (GO) - Molecular Function for SYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 19234194
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT2: view
genes like me logo Genes that share phenotypes with SYT2: view

miRNA for SYT2 Gene

miRTarBase miRNAs that target SYT2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYT2 Gene

Localization for SYT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT2 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT2 Gene COMPARTMENTS Subcellular localization image for SYT2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
mitochondrion 2
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030666 endocytic vesicle membrane --
genes like me logo Genes that share ontologies with SYT2: view

Pathways for SYT2 Gene

SuperPathways for SYT2 Gene

Superpath Contained pathways
1 Disease
2 Transmission across Chemical Synapses
genes like me logo Genes that share pathways with SYT2: view

Pathways by source for SYT2 Gene

2 Reactome pathways for SYT2 Gene

Gene Ontology (GO) - Biological Process for SYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0007268 synaptic transmission --
GO:0007269 neurotransmitter secretion --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
genes like me logo Genes that share ontologies with SYT2: view

Compounds for SYT2 Gene

(1) HMDB Compounds for SYT2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for SYT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Botulinum Toxin Type B
  • Botulinum neurotoxin type B precursor
93384-44-2 target

(3) Novoseek inferred chemical compound relationships for SYT2 Gene

Compound -log(P) Hits PubMed IDs
lysine 38.7 2
calcium 30.8 6
phospholipid 25.1 1
genes like me logo Genes that share compounds with SYT2: view

Transcripts for SYT2 Gene

mRNA/cDNA for SYT2 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT2 Gene

Synaptotagmin II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT2 Gene

No ASD Table

Relevant External Links for SYT2 Gene

GeneLoc Exon Structure for
SYT2
ECgene alternative splicing isoforms for
SYT2

Expression for SYT2 Gene

mRNA expression in normal human tissues for SYT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (13.6) and Brain - Cerebellum (13.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYT2 Gene

SOURCE GeneReport for Unigene cluster for SYT2 Gene Hs.25422

genes like me logo Genes that share expressions with SYT2: view

Orthologs for SYT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT2 36
  • 99.76 (n)
  • 100 (a)
SYT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT2 36
  • 89.13 (n)
  • 96.16 (a)
SYT2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt2 36
  • 89.42 (n)
  • 98.33 (a)
Syt2 16
Syt2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt2 36
  • 88.62 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves SYT2 36
  • 83.05 (n)
  • 88.32 (a)
SYT2 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt2 36
  • 74.17 (n)
  • 85.96 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.11215 36
LOC559637 36
  • 74.61 (n)
  • 74.94 (a)
SYT2 (1 of 2) 37
  • 72 (a)
OneToMany
syt2a 37
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8468 37
  • 66 (a)
OneToMany
Species with no ortholog for SYT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT2 Gene

ENSEMBL:
Gene Tree for SYT2 (if available)
TreeFam:
Gene Tree for SYT2 (if available)

Paralogs for SYT2 Gene

Paralogs for SYT2 Gene

Selected SIMAP similar genes for SYT2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SYT2 Gene

genes like me logo Genes that share paralogs with SYT2: view

Variants for SYT2 Gene

Sequence variations from dbSNP and Humsavar for SYT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs500569 -- 202,596,393(+) ATTTT(A/G)TTGGT utr-variant-3-prime
rs504261 -- 202,596,820(+) TGGGC(A/G)ATGGG reference, synonymous-codon
rs506135 -- 202,613,068(+) TCTTC(C/T)TTTTT intron-variant
rs511317 -- 202,607,017(+) CACTG(G/T)TAGAC intron-variant
rs513231 -- 202,607,271(+) GACTG(A/G)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT2 Gene

Variant ID Type Subtype PubMed ID
nsv832337 CNV Loss 17160897
dgv173e1 CNV Complex 17122850
esv2721617 CNV Deletion 23290073
esv2721628 CNV Deletion 23290073
esv2721639 CNV Deletion 23290073
esv2721650 CNV Deletion 23290073
esv3721 CNV Complex 18987735
esv2721661 CNV Deletion 23290073
esv2721672 CNV Deletion 23290073
nsv4099 CNV Insertion 18451855
nsv832348 CNV Loss 17160897
esv2545821 CNV Insertion 19546169
nsv7186 OTHER Inversion 18451855

Relevant External Links for SYT2 Gene

HapMap Linkage Disequilibrium report
SYT2
Human Gene Mutation Database (HGMD)
SYT2

Disorders for SYT2 Gene

UniProtKB/Swiss-Prot

SYT2_HUMAN
  • Myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy (MYSPC) [MIM:616040]: An autosomal dominant presynaptic neuromuscular junction disorder resembling Lambert-Eaton myasthenic syndrome. Affected individuals show foot deformities, a variable degree of proximal and distal limb weakness, muscle fatigue that improves with rest, mild gait difficulties, and reduced or absent deep tendon reflexes. {ECO:0000269 PubMed:25192047}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SYT2 Gene

genes like me logo Genes that share disorders with SYT2: view

Publications for SYT2 Gene

  1. Synaptotagmin II. A novel differentially distributed form of synaptotagmin. (PMID: 1856191) Geppert M. … SA1dhof T.C. (J. Biol. Chem. 1991) 3 23
  2. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. (PMID: 10330444) Baram D. … Sagi-Eisenberg R. (J. Exp. Med. 1999) 3 23
  3. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. (PMID: 15350218) Lee B.H. … Cobb M.H. (Mol. Cell 2004) 3 23
  4. Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. (PMID: 18639519) Shi J. … Wang H. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PMID: 7749232) Jones J.M. … Meisler M.H. (Mamm. Genome 1995) 2 3

Products for SYT2 Gene

Sources for SYT2 Gene

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