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SYT2 Gene

protein-coding   GIFtS: 60
GCID: GC01M202559

Synaptotagmin II

  See SYT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin II1 2 3
SytII2 3
Synaptotagmin 22
synaptotagmin-22

External Ids:    HGNC: 115101   Entrez Gene: 1278332   Ensembl: ENSG000001438587   OMIM: 6001045   UniProtKB: Q8N9I03   

Export aliases for SYT2 gene to outside databases

Previous GC identifers: GC01U990163 GC01M197998 GC01M199031 GC01M199853 GC01M199296 GC01M200826 GC01M173725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT2 Gene:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors
in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for SYT2 Gene:
SYT2 (synaptotagmin II) is a protein-coding gene. Diseases associated with SYT2 include botulism. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0
Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the
active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both
an acidic head group and a diacyl backbone (By similarity)

Gene Wiki entry for SYT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT2 gene promoter:
         SREBP-1c   Nkx2-5   GATA-1   SREBP-1b   GATA-2   AREB6   S8   E2F-1   SREBP-1a   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT2 promoter sequence
   Search Chromatin IP Primers for SYT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SYT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202559:  view genomic region     (about GC identifiers)

Start:
202,559,724 bp from pter      End:
202,679,551 bp from pter
Size:
119,828 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0 (See protein sequence)
Recommended Name: Synaptotagmin-2  
Size: 419 amino acids; 46872 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homotetramer (Probable). Interacts with stonin 2 (By similarity). Interacts with SCAMP5
Secondary accessions: Q496K5 Q8NBE5

Explore the universe of human proteins at neXtProt for SYT2: NX_Q8N9I0

Explore proteomics data for SYT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29
  • Modification sites at PhosphoSitePlus

  • See SYT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129976.1  NP_796376.2  

    ENSEMBL proteins: 
     ENSP00000356236   ENSP00000356237  
    Reactome Protein details: Q8N9I0

    SYT2 Human Recombinant Protein Products:

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    Novus Biologicals SYT2 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SYT2

     
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    SYT2 Antibody Products:

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    Abcam antibodies for SYT2 (P21579, Q9BQG1, Q8N9I0)
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    Cloud-Clone Corp. ELISAs for SYT2
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    Search eBioscience for ELISAs for SYT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR001565 Synaptotagmin
     IPR000008 C2_dom
     IPR015428 Synaptotagmin1/2

    Graphical View of Domain Structure for InterPro Entry Q8N9I0

    ProtoNet protein and cluster: Q8N9I0

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0
    Domain: The first C2 domain mediates Ca(2+)-dependent phospholipid binding (By similarity)
    Domain: The second C2 domain mediates interaction with Stonin 2 (By similarity)
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Find genes that share domains with SYT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT2_HUMAN, Q8N9I0
    Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the
    active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both
    an acidic head group and a diacyl backbone (By similarity)

         Genatlas biochemistry entry for SYT2:
    synaptotagmin 2,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved
    in exocytosis and endocytosis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19234194
    GO:0005544calcium-dependent phospholipid binding IEA--
         
    Find genes that share ontologies with SYT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT2:
     Increased CXCL12 induced migra  Increased G2M DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Syt2):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with SYT2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYT2:
    hsa-mir-125b-2-3p (MIRT038632)

    Block miRNA regulation of human, mouse, rat SYT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT2 (see all 121):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-128 hsa-miR-383 hsa-miR-149 hsa-miR-192* hsa-miR-761 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSYT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYT2
    Predesigned siRNA for gene silencing in human, mouse, rat SYT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYT2

    Clone
    Products:
         
    OriGene clones in human, mouse for SYT2 (see all 9)
    OriGene ORF clones in mouse, rat for SYT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT2 (NM_020728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYT2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT2_HUMAN, Q8N9I0: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass
    membrane protein (By similarity). Note=Synaptic vesicles and chromaffin granules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    mitochondrion2
    endosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030666endocytic vesicle membrane TAS--
    GO:0030672synaptic vesicle membrane IEA--

    Find genes that share ontologies with SYT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Neuronal System0.68
    2Disease
    Disease


    Find genes that share SuperPaths with SYT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SYT2
        Toxicity of botulinum toxin type B (BoNT/B)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT2
    Interactions:

        Search GeneGlobe Interaction Network for SYT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SYT2 (Q8N9I02, 3 ENSP000003562364) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STON2Q8WXE93, ENSP000002675404I2D: score=2 STRING: ENSP00000267540
    KLHL3Q9UH773, ENSP000003123974I2D: score=1 STRING: ENSP00000312397
    WNK1Q9H4A33, ENSP000003130594I2D: score=2 STRING: ENSP00000313059
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--

    Find genes that share ontologies with SYT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT2

    1 HMDB Compound for SYT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for SYT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type BBotulinum neurotoxin type B precursor (see all 2)93384-44-2target--19576489 17016423 17139284

    3 Novoseek inferred chemical compound relationships for SYT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 38.7 4 7592870 (1), 18234667 (1)
    calcium 30.8 8 15350218 (2), 17988208 (1), 19709623 (1), 11755789 (1) (see all 5)
    phospholipid 25.1 1 15350218 (1)



    Find genes that share compounds with SYT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYT2 gene (2 alternative transcripts): 
    NM_001136504.1  NM_177402.4  

    Unigene Cluster for SYT2:

    Synaptotagmin II
    Hs.25422  [show with all ESTs]
    Unigene Representative Sequence: NM_001136504
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367267(uc001gye.3) ENST00000367268(uc010pqb.2 uc009xaf.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT2 (see all 121):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-128 hsa-miR-383 hsa-miR-149 hsa-miR-192* hsa-miR-761 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSYT2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT2 (NM_020728)
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      QuantiTect SYBR Green Assays in human, mouse, rat SYT2
      QuantiFast Probe-based Assays in human, mouse, rat SYT2

    Additional mRNA sequence: 

    AF070580.1 AK090672.1 AK094430.1 AK124510.1 BC100814.1 BC100815.1 BC100816.1 BC100817.1 

    3 DOTS entries:

    DT.100011141  DT.410065  DT.100011140 

    4 AceView cDNA sequences:

    AK090672 NM_177402 AK094430 BF887052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCCCTT
    SYT2 Expression
    About this image


    SYT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neurons
             Type6 On Cone Bipolar Cells Inner Nuclear Layer
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Type6 On Cone Bipolar Cells Inner Nuclear Layer
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
    SYT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25422
        Custom PCR Arrays for SYT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYT2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt21 , 5 synaptotagmin II1, 5 89.42(n)1
    98.33(a)1
      1 (58.24 cM)5
    209801  NM_009307.31  NP_033333.21 
     1347093005 
    chicken
    (Gallus gallus)
    Aves SYT21 synaptotagmin II 83.05(n)
    88.32(a)
      396327  XM_003642713.2  XP_003642761.2 
    lizard
    (Anolis carolinensis)
    Reptilia SYT26
    synaptotagmin II
    85(a)
    1 ↔ 1
    4(131779953-131966641)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia syt21 synaptotagmin II 74.17(n)
    85.96(a)
      100493529  XM_002932123.2  XP_002932169.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.112152 Transcribed sequence with weak similarity to protein more 73.98(n)    CK028679.1 


    ENSEMBL Gene Tree for SYT2 (if available)
    TreeFam Gene Tree for SYT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT2 gene
    SYT152  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  
    SYT172  SYT112  SYT122  SYT72  SYT12  
    Selected SIMAP similar genes for SYT2 using alignment to 2 protein entries:     SYT2_HUMAN (see all proteins) (see all similar genes):
    SYT1    SYT5    SYT9    SYT10    SYT6    SYT7
    SYT3    SYT17    SYT8    SYT11    SYT4    DKFZp434D2429
    SYT12    SYT15    CHR11SYT    SYTL4    DOC2B    SYTL1

    Find genes that share paralogs with SYT2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SYT2
    PGOHUM00000246707 PGOHUM00000247069


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT2 (see all 2562)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168500761,2
    C,F,H--202559232(+) TTAAAG/AACATT 2 -- ds500112Minor allele frequency- A:0.08NA NS EA CSA WA 1352
    rs1116561871,2
    C,F--202559323(+) CCTCTC/TGTCAT 2 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1487645371,2
    --202559407(+) ACCCCA/GCCCCG 2 -- ds50010--------
    rs2008235741,2
    C--202559447(+) CCACC-/CACTCC 2 -- ds50010--------
    rs1448698781,2
    C--202559653(+) CCTCAA/CAGGCA 2 -- ds50010--------
    rs2021313001,2
    --202559748(+) TTAAT-/AAGGAG 2 -- ut310--------
    rs10462691,2
    C,F,H--202559753(-) TGCGTC/ATCCTT 2 -- ut31 ese326Minor allele frequency- A:0.09NA NS EA 3218
    rs1150940981,2
    C,F--202559771(+) ACAAAA/GTAACA 2 -- ut311Minor allele frequency- G:0.02WA 118
    rs1167165501,2
    C,F--202559931(+) TTGGCG/AAAGCT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs1473758931,2
    --202559939(+) GCTAGG/TCTCTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT2 (202559724 - 202679551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYT2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721672CNV Deletion23290073
    esv2721617CNV Deletion23290073
    esv2721628CNV Deletion23290073
    esv2721661CNV Deletion23290073
    esv2721639CNV Deletion23290073
    esv2721650CNV Deletion23290073
    nsv4099CNV Insertion18451855
    esv2545821CNV Insertion19546169
    nsv832337CNV Loss17160897
    nsv832348CNV Loss17160897

    Human Gene Mutation Database (HGMD): SYT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600104    OMIM disorders: --

    1 disease for SYT2:    
    About MalaCards
    botulism

    1 disease from the University of Copenhagen DISEASES database for SYT2:
    Botulism

    Find genes that share disorders with SYT2           About GenesLikeMe


    Export disorders for SYT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT2 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with SYT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. (PubMed id 19234194)1, 2 Han C.... Cao X. (J. Immunol. 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PubMed id 7749232)1, 3 Jones J.M....Meisler M.H. (Mamm. Genome 1995)
    5. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. (PubMed id 15350218)1, 9 Lee B.H....Cobb M.H. (Mol. Cell 2004)
    6. Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. (PubMed id 18639519)1, 9 Shi J....Wang H. (Biochem. Biophys. Res. Commun. 2008)
    7. Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II. (PubMed id 11696368)1, 9 Kida Y....Mihara K. (FEBS Lett. 2001)
    8. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. (PubMed id 10330444)1, 9 Baram D....Sagi-Eisenberg R. (J. Exp. Med. 1999)
    9. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
    10. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. (PubMed id 22454523)1 Peng L....Dong M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127833 HGNC: 11510 AceView: SYT2 Ensembl:ENSG00000143858 euGenes: HUgn127833
    ECgene: SYT2 H-InvDB: SYT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SYT2 gene:
    Search GeneIP for patents involving SYT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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