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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT2 Gene

protein-coding   GIFtS: 59
GCID: GC01M202559

Synaptotagmin II

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin II1 2 3
SytII2 3
Synaptotagmin 22
synaptotagmin-22

External Ids:    HGNC: 115101   Entrez Gene: 1278332   Ensembl: ENSG000001438587   OMIM: 6001045   UniProtKB: Q8N9I03   

Export aliases for SYT2 gene to outside databases

Previous GC identifers: GC01U990163 GC01M197998 GC01M199031 GC01M199853 GC01M199296 GC01M200826 GC01M173725


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYT2 Gene:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors
in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for SYT2 Gene: 
SYT2 (synaptotagmin II) is a protein-coding gene. Diseases associated with SYT2 include infant botulism, and botulism, and among its related super-pathways are Proteolytic cleavage of SNARE complex proteins and Transmission across Chemical Synapses. GO annotations related to this gene include calcium-dependent phospholipid binding and calcium ion binding. An important paralog of this gene is DOC2B.

UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0
Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the
active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both
an acidic head group and a diacyl backbone (By similarity)

Gene Wiki entry for SYT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT2 gene promoter:
         SREBP-1c   Nkx2-5   GATA-1   SREBP-1b   GATA-2   AREB6   S8   E2F-1   SREBP-1a   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

SYT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202559:  view genomic region     (about GC identifiers)

Start:
202,559,724 bp from pter      End:
202,679,551 bp from pter
Size:
119,828 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0 (See protein sequence)
Recommended Name: Synaptotagmin-2  
Size: 419 amino acids; 46872 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homotetramer (Probable). Interacts with stonin 2 (By similarity). Interacts with SCAMP5
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
protein (By similarity). Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass
membrane protein (By similarity). Note=Synaptic vesicles and chromaffin granules (By similarity)
Secondary accessions: Q496K5 Q8NBE5

Explore the universe of human proteins at neXtProt for SYT2: NX_Q8N9I0

Explore proteomics data for SYT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N9I0

  • SYT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129976.1  NP_796376.2  

    ENSEMBL proteins: 
     ENSP00000356236   ENSP00000356237  
    Reactome Protein details: Q8N9I0
    Human Recombinant Protein Products for SYT2: 
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    Novus Biologicals SYT2 Protein
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    Cloud-Clone Corp. Proteins for SYT2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030666endocytic vesicle membrane TAS--
    GO:0030672synaptic vesicle membrane IEA--

    SYT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SYT: Synaptotagmins

    5 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR020477 C2_dom
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q8N9I0

    ProtoNet protein and cluster: Q8N9I0

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT2_HUMAN, Q8N9I0
    Domain: The first C2 domain mediates Ca(2+)-dependent phospholipid binding (By similarity)
    Domain: The second C2 domain mediates interaction with Stonin 2 (By similarity)
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT2_HUMAN, Q8N9I0
    Function: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the
    active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both
    an acidic head group and a diacyl backbone (By similarity)

         Genatlas biochemistry entry for SYT2:
    synaptotagmin 2,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved
    in exocytosis and endocytosis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19234194
    GO:0005544calcium-dependent phospholipid binding IEA--
         
    SYT2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT2:
     Increased CXCL12 induced migra  Increased G2M DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Syt2):
     behavior/neurological  growth/size  mortality/aging  nervous system  reproductive system 

    SYT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT2 
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    hsa-miR-194* hsa-miR-3607-3p hsa-miR-128 hsa-miR-383 hsa-miR-149 hsa-miR-192* hsa-miR-761 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidSYT2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Botulinum neurotoxicity
    Botulinum neurotoxicity0.89
    2Transmission across Chemical Synapses
    Neuronal System0.67
    3Translocation of BoNT Light chain
    Translocation of BoNT Light chain
    4Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SYT2
        Translocation of BoNT Light chain
    Botulinum neurotoxicity
    Neuronal System
    Disease



    SYT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/14 Interacting proteins for SYT2 (Q8N9I02, 3 ENSP000003562364) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STON2Q8WXE93, ENSP000002675404I2D: score=2 STRING: ENSP00000267540
    KLHL3Q9UH773, ENSP000003123974I2D: score=1 STRING: ENSP00000312397
    WNK1Q9H4A33, ENSP000003130594I2D: score=2 STRING: ENSP00000313059
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--

    SYT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT2

    1 HMDB Compound for SYT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for SYT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Botulinum Toxin Type BBotulinum neurotoxin type B precursor (see all 2)93384-44-2target--19576489 17016423 17139284

    3 Novoseek inferred chemical compound relationships for SYT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 38.7 4 7592870 (1), 18234667 (1)
    calcium 30.8 8 15350218 (2), 17988208 (1), 19709623 (1), 11755789 (1) (see all 5)
    phospholipid 25.1 1 15350218 (1)

    Search CenterWatch for drugs/clinical trials and news about SYT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYT2 gene (2 alternative transcripts): 
    NM_001136504.1  NM_177402.4  

    Unigene Cluster for SYT2:

    Synaptotagmin II
    Hs.25422  [show with all ESTs]
    Unigene Representative Sequence: NM_001136504
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367267(uc001gye.3) ENST00000367268(uc010pqb.2 uc009xaf.3)


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    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT2 (see all 121):
    hsa-miR-194* hsa-miR-3607-3p hsa-miR-128 hsa-miR-383 hsa-miR-149 hsa-miR-192* hsa-miR-761 hsa-miR-92b
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    Additional mRNA sequence: 

    AF070580.1 AK090672.1 AK094430.1 AK124510.1 BC100814.1 BC100815.1 BC100816.1 BC100817.1 

    3 DOTS entries:

    DT.100011141  DT.410065  DT.100011140 

    4 AceView cDNA sequences:

    NM_177402 AK090672 AK094430 BF887052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT2 expression in normal human tissues (normalized intensities)      SYT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGCCCTT
    SYT2 Expression
    About this image


    SYT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Type2 Off Cone Bipolar Cells Inner Nuclear Layer

    See SYT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT2

    SOURCE GeneReport for Unigene cluster: Hs.25422
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYT2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt21 , 5 synaptotagmin II1, 5 89.42(n)1
    98.33(a)1
      1 (58.24 cM)5
    209801  NM_009307.31  NP_033333.21 
     1347093005 
    chicken
    (Gallus gallus)
    Aves SYT21 synaptotagmin II 85.59(n)
    92.14(a)
      396327  XM_003642713.1  XP_003642761.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYT26
    SYT56
    Uncharacterized protein
    86(a)
    66(a)
    1 ↔ 1
    possible ortholog
    4(131779953-131966641)
    GL343355.1(896857-939287)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.112152 Transcribed sequence with weak similarity to protein more 73.98(n)    CK028679.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syt16
    Synaptotagmin 1
    49(a)
    1 → many
    2L(2779267-2799979)


    ENSEMBL Gene Tree for SYT2 (if available)
    TreeFam Gene Tree for SYT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT2 gene
    DOC2B2  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  
    SYT172  SYT112  SYT122  DOC2A2  SYT72  RPH3A2  SYT12  
    18/19 SIMAP similar genes for SYT2 using alignment to 2 protein entries:     SYT2_HUMAN (see all proteins) (see all similar genes):
    SYT1    SYT5    SYT9    SYT10    SYT6    SYT7
    SYT3    SYT17    SYT8    SYT11    SYT4    DKFZp434D2429
    SYT12    SYT15    CHR11SYT    SYTL4    RPH3A    DOC2B

    SYT2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SYT2
    PGOHUM00000246707 PGOHUM00000247069


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2562 SNPs in SYT2 are shown (see all 2562)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs168500761,2
    C,F,H--202559232(+) TTAAAG/AACATT 2 -- ds500112Minor allele frequency- A:0.08NA NS EA CSA WA 1352
    rs1116561871,2
    C,F--202559323(+) CCTCTC/TGTCAT 2 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1487645371,2
    --202559407(+) ACCCCA/GCCCCG 2 -- ds50010--------
    rs2008235741,2
    C--202559447(+) CCACC-/CACTCC 2 -- ds50010--------
    rs1448698781,2
    C--202559653(+) CCTCAA/CAGGCA 2 -- ds50010--------
    rs2021313001,2
    --202559748(+) TTAAT-/AAGGAG 2 -- ut310--------
    rs10462691,2
    C,F,H--202559753(-) TGCGTC/ATCCTT 2 -- ut31 ese326Minor allele frequency- A:0.09NA NS EA 3218
    rs1150940981,2
    C,F--202559771(+) ACAAAA/GTAACA 2 -- ut311Minor allele frequency- G:0.02WA 118
    rs1167165501,2
    C,F--202559931(+) TTGGCG/AAAGCT 2 -- ut311Minor allele frequency- A:0.01WA 118
    rs1473758931,2
    --202559939(+) GCTAGG/TCTCTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT2 (202559724 - 202679551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for SYT2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721672CNV Deletion23290073
    esv2721617CNV Deletion23290073
    esv2721628CNV Deletion23290073
    esv2721661CNV Deletion23290073
    esv2721639CNV Deletion23290073
    esv2721650CNV Deletion23290073
    nsv4099CNV Insertion18451855
    esv2545821CNV Insertion19546169
    nsv832337CNV Loss17160897
    nsv832348CNV Loss17160897


    Human Gene Mutation Database (HGMD): SYT2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600104    OMIM disorders: --

    5 diseases for SYT2:    About MalaCards
    infant botulism    botulism    paralysis    pancreatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SYT2:
    Botulism

    SYT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for SYT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT2 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with SYT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. (PubMed id 19234194)1, 2 Han C.... Cao X. (2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. (PubMed id 7749232)1, 3 Jones J.M....Meisler M.H. (1995)
    5. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. (PubMed id 15350218)1, 9 Lee B.H....Cobb M.H. (2004)
    6. Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. (PubMed id 18639519)1, 9 Shi J....Wang H. (2008)
    7. Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II. (PubMed id 11696368)1, 9 Kida Y....Mihara K. (2001)
    8. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. (PubMed id 10330444)1, 9 Baram D....Sagi-Eisenberg R. (1999)
    9. Botulinum neurotoxin D-C uses synaptotagmin I and II a s receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. (PubMed id 22454523)1 Peng L....Dong M. (2012)
    10. Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenici ty. (PubMed id 22265973)1 Strotmeier J....Rummel A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127833 HGNC: 11510 AceView: SYT2 Ensembl:ENSG00000143858 euGenes: HUgn127833
    ECgene: SYT2 H-InvDB: SYT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYT2 gene:
    Search GeneIP for patents involving SYT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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