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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT17 Gene

protein-coding   GIFtS: 49
GCID: GC16P019179

Synaptotagmin XVII

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin XVII1 2 3
B/K Protein1 2
Protein B/K2 3
synaptotagmin-172
sytXVII2
SytXVII3

External Ids:    HGNC: 241191   Entrez Gene: 517602   Ensembl: ENSG000001035287   UniProtKB: Q9BSW73   

Export aliases for SYT17 gene to outside databases

Previous GC identifers: GC16P019088 GC16P017717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYT17 Gene: 
SYT17 (synaptotagmin XVII) is a protein-coding gene. Diseases associated with SYT17 include choroiditis, and alcoholism. GO annotations related to this gene include transporter activity. An important paralog of this gene is DOC2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT17 gene promoter:
         LHX3b/Lhx3b   Pax-5   NF-kappaB   LCR-F1   c-Ets-1   PPAR-gamma1   LHX3a/Lhx3a   PPAR-gamma2   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT17 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

SYT17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT17 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019179:  view genomic region     (about GC identifiers)

Start:
19,179,293 bp from pter      End:
19,279,652 bp from pter
Size:
100,360 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYT17_HUMAN, Q9BSW7 (See protein sequence)
Recommended Name: Synaptotagmin-17  
Size: 474 amino acids; 53849 Da
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for SYT17:
2ENP (3D)    
Secondary accessions: O43330 Q9NZ18

Explore the universe of human proteins at neXtProt for SYT17: NX_Q9BSW7

Explore proteomics data for SYT17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSW7

  • SYT17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYT17 Protein Expression
    REFSEQ proteins: NP_057608.2  
    ENSEMBL proteins: 
     ENSP00000456790   ENSP00000454335   ENSP00000347538   ENSP00000456009   ENSP00000456252  
     ENSP00000454721   ENSP00000456879   ENSP00000456915  

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    Cloud-Clone Corp. Proteins for SYT17 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005802trans-Golgi network IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0016020membrane IEA--

    SYT17 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SYT: Synaptotagmins

    5 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR014705 BKprotein
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9BSW7

    ProtoNet protein and cluster: Q9BSW7

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: SYT17_HUMAN, Q9BSW7
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
         
    SYT17 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for SYT17 (Q9BSW72, 3 ENSP000003475384) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-66651 I2D: score=5 STRING: ENSP00000311695
    NINLQ9Y2I62, 3, ENSP000002788864MINT-67395 I2D: score=5 STRING: ENSP00000278886
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2873647 I2D: score=3 STRING: ENSP00000400806
    MDP1Q86V882, 3, ENSP000002880874MINT-67169 I2D: score=1 STRING: ENSP00000288087
    TSC22D4Q9Y3Q82, 3, ENSP000003001814MINT-67942 I2D: score=5 STRING: ENSP00000300181
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT17

    Search CenterWatch for drugs/clinical trials and news about SYT17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYT17 gene: 
    NM_016524.2  

    Unigene Cluster for SYT17:

    Synaptotagmin XVII
    Hs.258326  [show with all ESTs]
    Unigene Representative Sequence: AK226136
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570264 ENST00000566261 ENST00000355377(uc002dfw.3) ENST00000568115
    ENST00000562034(uc002dfx.3 uc002dfy.3) ENST00000562711 ENST00000562274
    ENST00000565183 ENST00000568433
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT17:
    hsa-miR-4297 hsa-miR-642b
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF220560.1 AK098747.1 AK226136.1 AK296000.1 BC004518.2 

    9 DOTS entries:

    DT.110320  DT.97837404  DT.100695793  DT.120688358  DT.92421583  DT.75162435  DT.120688318  DT.40131551 
    DT.97804350 

    24/89 AceView cDNA sequences (see all 89):

    CR595216 CA389452 BF196505 AA253461 H23376 BM714007 AA372001 BX106395 
    BF942106 AW136805 BX088745 AA250917 AK098747 BQ272543 BQ267300 CA771221 
    BM982070 NM_016524 BQ548669 CA771529 BQ070945 AI654652 BC004518 AI568084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT17 expression in normal human tissues (normalized intensities)      SYT17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAACACGC
    SYT17 Expression
    About this image


    SYT17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Substantia Nigra   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See SYT17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT17

    SOURCE GeneReport for Unigene cluster: Hs.258326

    UniProtKB/Swiss-Prot: SYT17_HUMAN, Q9BSW7
    Tissue specificity: Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus,
    amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYT17 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt171 , 5 synaptotagmin XVII1, 5 88.13(n)1
    96.16(a)1
      7 (63.44 cM)5
    1100581  NM_138649.11  NP_619590.11 
     1183818565 
    chicken
    (Gallus gallus)
    Aves SYT171 synaptotagmin XVII 75.38(n)
    82.14(a)
      416608  XM_414910.3  XP_414910.3 
    lizard
    (Anolis carolinensis)
    Reptilia SYT176
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343769.1(203791-214178)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000003741 synaptotagmin-17-like 71.08(n)
    74.57(a)
      100000374  XM_001922473.3  XP_001922508.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sytalpha6
    Synaptotagmin alpha
    24(a)
    1 → many
    2L(17592260-17603640)


    ENSEMBL Gene Tree for SYT17 (if available)
    TreeFam Gene Tree for SYT17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT17 gene
    DOC2B2  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  
    SYT112  SYT122  SYT22  DOC2A2  SYT72  RPH3A2  SYT12  
    13 SIMAP similar genes for SYT17 using alignment to 8 protein entries:     SYT17_HUMAN (see all proteins):
    SYT2    SYT1    SYT5    PRKCG    SYT7    CHR11SYT
    SYT4    SYT10    SYT11    SYT9    DKFZp434D2429    SYT6
    SYT15

    SYT17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2325 SNPs in SYT17 are shown (see all 2325)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671229391,2
    C--17805069(+) GAGTC-/TATTATTAT/T
    ATTATTATTATTAT
    TATTA
    2 -- int1 cds11NA 2
    rs20041631,2
    C--19177639(-) ggaggC/Tggagg 1 -- us2k10--------
    rs1417793911,2
    --19177694(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1501449551,2
    --19177715(+) TGCCCA/GGCTAT 1 -- us2k10--------
    rs1820861821,2
    --19177743(+) GAGACA/GGAGTT 1 -- us2k10--------
    rs1866792591,2
    --19177773(+) GATCTC/TGAACT 1 -- us2k10--------
    rs1385733781,2
    --19177785(+) CTGACC/TTCAGG 1 -- us2k10--------
    rs1143795451,2
    F--19177816(+) TTACTT/CATGGG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs778939231,2
    F--19177872(+) CACCCG/ATTCCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1923513551,2
    --19177919(+) GGCATA/GCCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYT17 (19179293 - 19279652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SYT17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1661893CNV Deletion17803354
    esv5037CNV Deletion18987735
    esv998101CNV Deletion20482838
    esv2550711CNV Deletion19546169
    esv2418352CNV Deletion18987734
    esv2714047CNV Deletion23290073
    esv993801CNV Deletion20482838
    nsv436835CNV Insertion17901297
    nsv833162CNV Loss17160897
    esv8609CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for SYT17:    About MalaCards
    choroiditis    alcoholism    prostatitis


    SYT17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYT17
    Human Genome Epidemiology (HuGE) Navigator: SYT17 (1 document)

    Export disorders for SYT17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT17 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with SYT17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Protein kinase A-dependent phosphorylation of B/K protein. (PubMed id 16672768)1, 2 Chin H.... Kwon O.-J. (2006)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Confirmation of prior evidence of genetic susceptibili ty to alcoholism in a genome-wide association study of comorbid alcoholism and b ipolar disorder. (PubMed id 21876473)1 Lydall G.J....Gurling H.M. (2011)
    6. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1 Tsang H.T.H....Sanderson C.M. (2006)
    7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51760 HGNC: 24119 AceView: LOC51760 Ensembl:ENSG00000103528 euGenes: HUgn51760
    ECgene: SYT17 H-InvDB: SYT17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYT17 gene:
    Search GeneIP for patents involving SYT17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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