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Aliases for SYT17 Gene

Aliases for SYT17 Gene

  • Synaptotagmin 17 2 3 5
  • Synaptotagmin XVII 2 3 4
  • B/K Protein 2 3
  • SytXVII 3 4
  • Synaptotagmin-17 3
  • Protein B/K 4

External Ids for SYT17 Gene

Previous GeneCards Identifiers for SYT17 Gene

  • GC16P019088
  • GC16P017717

Summaries for SYT17 Gene

GeneCards Summary for SYT17 Gene

SYT17 (Synaptotagmin 17) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot for SYT17 Gene

  • Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Additional gene information for SYT17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT17 Gene

Genomics for SYT17 Gene

Regulatory Elements for SYT17 Gene

Enhancers for SYT17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H019209 1.5 FANTOM5 Ensembl ENCODE 17.2 +43.5 43522 3 HDGF TBL1XR1 BMI1 BATF RAD21 ZNF143 ZNF207 ATF7 RUNX3 IKZF2 SYT17 COQ7 RNU4-46P SMG1 CLEC19A
GH16H019129 1.5 Ensembl ENCODE dbSUPER 12.2 -36.4 -36422 3 FOXA2 ATF1 FEZF1 FOS RUNX3 SP3 JUNB TSHZ1 REST ZNF518A PKD1P5 NPIPA8 SYT17 ENSG00000205746 COQ7 ENSG00000261759
GH16H019135 1.5 Ensembl ENCODE dbSUPER 12.2 -31.3 -31300 2 PKNOX1 FOXA2 SIN3A FEZF1 TCF12 GLIS2 FOS KLF7 SP5 TSHZ1 SYT17 COQ7 ENSG00000261759
GH16H019107 1.5 Ensembl ENCODE dbSUPER 11.7 -59.8 -59761 1 HDGF FOXA2 ATF1 ZFP64 ARID4B DMAP1 ZNF2 FOS ATF7 RUNX3 SYT17 COQ7 RNU4-46P GC16P019109 ENSG00000260430
GH16H019392 1.2 Ensembl ENCODE 14.4 +227.1 227118 5 FOXA2 FEZF1 YY1 TCF12 FOS ATF7 SMARCA4 STAT3 NBN HMBOX1 TMC5 SYT17 RNU4-46P COQ7 ENSG00000280265 ENSG00000259925
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYT17 on UCSC Golden Path with GeneCards custom track

Promoters for SYT17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084152 429 1201 SIN3A GLI4 GLIS2 ZNF143 ZNF207 SP3 SP5 YY2 REST SMARCB1

Genomic Location for SYT17 Gene

Chromosome:
16
Start:
19,167,971 bp from pter
End:
19,268,334 bp from pter
Size:
100,364 bases
Orientation:
Plus strand

Genomic View for SYT17 Gene

Genes around SYT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT17 Gene

Proteins for SYT17 Gene

  • Protein details for SYT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSW7-SYT17_HUMAN
    Recommended name:
    Synaptotagmin-17
    Protein Accession:
    Q9BSW7
    Secondary Accessions:
    • O43330
    • Q9NZ18

    Protein attributes for SYT17 Gene

    Size:
    474 amino acids
    Molecular mass:
    53849 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SYT17 Gene

neXtProt entry for SYT17 Gene

Post-translational modifications for SYT17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT17 Gene

Domains & Families for SYT17 Gene

Gene Families for SYT17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYT17 Gene

Suggested Antigen Peptide Sequences for SYT17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BSW7

UniProtKB/Swiss-Prot:

SYT17_HUMAN :
  • Belongs to the synaptotagmin family.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT17: view

Function for SYT17 Gene

Molecular function for SYT17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Phenotypes From GWAS Catalog for SYT17 Gene

Gene Ontology (GO) - Molecular Function for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT17: view
genes like me logo Genes that share phenotypes with SYT17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYT17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT17 Gene

Localization for SYT17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT17 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT17 gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 3
golgi apparatus 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0098793 presynapse IEA --
genes like me logo Genes that share ontologies with SYT17: view

Pathways & Interactions for SYT17 Gene

SuperPathways for SYT17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0030154 cell differentiation IEA --
GO:0046928 regulation of neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with SYT17: view

No data available for Pathways by source and SIGNOR curated interactions for SYT17 Gene

Drugs & Compounds for SYT17 Gene

No Compound Related Data Available

Transcripts for SYT17 Gene

Unigene Clusters for SYT17 Gene

Synaptotagmin XVII:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYT17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SYT17 Gene

No ASD Table

Relevant External Links for SYT17 Gene

GeneLoc Exon Structure for
SYT17
ECgene alternative splicing isoforms for
SYT17

Expression for SYT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT17 Gene

mRNA differential expression in normal tissues according to GTEx for SYT17 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1) and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for SYT17 Gene

This gene is overexpressed in Fetal Brain (47.2) and Frontal cortex (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT17 Gene



Protein tissue co-expression partners for SYT17 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYT17 Gene:

SYT17

SOURCE GeneReport for Unigene cluster for SYT17 Gene:

Hs.258326

mRNA Expression by UniProt/SwissProt for SYT17 Gene:

Q9BSW7-SYT17_HUMAN
Tissue specificity: Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidney and lung (PubMed:16672768). Expressed in melanocytes (PubMed:23999003).

Evidence on tissue expression from TISSUES for SYT17 Gene

  • Lung(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SYT17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT17 Gene

Orthologs for SYT17 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT17 33 34
  • 97.79 (n)
dog
(Canis familiaris)
Mammalia SYT17 33
  • 91.91 (n)
-- 34
  • 84 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SYT17 33 34
  • 90.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SYT17 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt17 33 16 34
  • 88.13 (n)
rat
(Rattus norvegicus)
Mammalia Syt17 33
  • 87.9 (n)
oppossum
(Monodelphis domestica)
Mammalia SYT17 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT17 33 34
  • 74.27 (n)
lizard
(Anolis carolinensis)
Reptilia SYT17 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt17 33
  • 76.23 (n)
zebrafish
(Danio rerio)
Actinopterygii SYT17 34
  • 73 (a)
OneToOne
LOC100000374 33
  • 70.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sytalpha 34
  • 25 (a)
OneToOne
Species where no ortholog for SYT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT17 Gene

ENSEMBL:
Gene Tree for SYT17 (if available)
TreeFam:
Gene Tree for SYT17 (if available)

Paralogs for SYT17 Gene

Paralogs for SYT17 Gene

genes like me logo Genes that share paralogs with SYT17: view

Variants for SYT17 Gene

Sequence variations from dbSNP and Humsavar for SYT17 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000039039 -- 19,226,266(+) CAAAC(A/T)CCCAG intron-variant
rs1000126387 -- 19,221,593(+) TACAG(A/G)AATCT intron-variant
rs1000164000 -- 19,175,358(+) TAATC(-/AA)GAGAT intron-variant
rs1000196389 -- 19,268,158(+) AATGT(C/T)ACGTC intron-variant, utr-variant-3-prime
rs1000198718 -- 19,229,278(+) TGGCT(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT17 Gene

Variant ID Type Subtype PubMed ID
dgv1311n106 CNV deletion 24896259
dgv487e214 CNV gain 21293372
esv1661893 CNV deletion 17803354
esv2418352 CNV deletion 18987734
esv2550711 CNV deletion 19546169
esv2714047 CNV deletion 23290073
esv3202679 CNV deletion 24192839
esv3553198 CNV deletion 23714750
esv3570409 CNV gain 25503493
esv3638122 CNV loss 21293372
esv5037 CNV loss 18987735
esv8609 CNV loss 19470904
esv993801 CNV deletion 20482838
esv998101 CNV deletion 20482838
nsv1045019 CNV gain 25217958
nsv1070497 CNV deletion 25765185
nsv436835 CNV insertion 17901297
nsv571579 CNV gain 21841781
nsv571582 CNV gain 21841781
nsv833162 CNV loss 17160897
nsv958199 CNV deletion 24416366

Variation tolerance for SYT17 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT17 Gene

Disorders for SYT17 Gene

Relevant External Links for SYT17

Genetic Association Database (GAD)
SYT17
Human Genome Epidemiology (HuGE) Navigator
SYT17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT17

No disorders were found for SYT17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT17 Gene

Publications for SYT17 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 60
  2. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo JC … Yoon TJ (Journal of dermatological science 2013) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Protein kinase A-dependent phosphorylation of B/K protein. (PMID: 16672768) Chin H … Kwon OJ (Experimental & molecular medicine 2006) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SYT17 Gene

Sources for SYT17 Gene

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