Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYT16 Gene

Aliases for SYT16 Gene

  • Synaptotagmin 16 2 3 5
  • Synaptotagmin XIV-Related Protein 3 4
  • Synaptotagmin 14-Like Protein 3 4
  • Chr14 Synaptotagmin 2 3
  • Synaptotagmin XVI 2 3
  • CHR14SYT 3 4
  • Strep14 3 4
  • SYT14L 3 4
  • Syt14r 3 4
  • Synaptotagmin XIV-Related 2
  • Synaptotagmin XIV-Like 2
  • Synaptotagmin-16 3
  • CTD-2277K2.1 3
  • Yt14r 3

External Ids for SYT16 Gene

Previous HGNC Symbols for SYT16 Gene

  • SYT14L

Previous GeneCards Identifiers for SYT16 Gene

  • GC14P061533
  • GC14P062462
  • GC14P042626
  • GC14P061970

Summaries for SYT16 Gene

GeneCards Summary for SYT16 Gene

SYT16 (Synaptotagmin 16) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is SYT14.

UniProtKB/Swiss-Prot for SYT16 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Additional gene information for SYT16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT16 Gene

Genomics for SYT16 Gene

Regulatory Elements for SYT16 Gene

Enhancers for SYT16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H061964 0.6 ENCODE 11.7 +153.4 153371 1 JUN CEBPB EP300 RFX5 JUND MAFF CEBPA STAT3 FOS TCF7L2 SYT16 GC14P061915 GC14M061941
GH14H061580 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -227.1 -227137 8 FOXA2 FEZF1 ZNF2 FOS ATF7 REST ZNF518A NFIL3 STAT3 HNF4A HIF1A SYT16 GC14P061590 LOC101927780
GH14H061615 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -195.7 -195677 1 JUND ZMYM3 KDM1A FLJ22447 LOC101927780 HIF1A SYT16 GC14P061590 GC14P061694
GH14H061510 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -297.8 -297758 8 ELF3 TBP PKNOX1 FOXA2 RAD21 RARA YY1 RCOR1 SMARCA5 ZC3H11A HIF1A FLJ22447 LOC101927780 PRKCH SYT16 ENSG00000258989 GC14M061347
GH14H061965 0.2 ENCODE 11.1 +152.1 152124 0 SYT16 GC14P061915 GC14M061941
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYT16 on UCSC Golden Path with GeneCards custom track

Promoters for SYT16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069443 626 401 MXI1 POLR2A ZBTB8A ZBTB26 EZH2

Genomic Location for SYT16 Gene

Chromosome:
14
Start:
61,811,974 bp from pter
End:
62,117,043 bp from pter
Size:
305,070 bases
Orientation:
Plus strand

Genomic View for SYT16 Gene

Genes around SYT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT16 Gene

Proteins for SYT16 Gene

  • Protein details for SYT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RD7-SYT16_HUMAN
    Recommended name:
    Synaptotagmin-16
    Protein Accession:
    Q17RD7
    Secondary Accessions:
    • B4DZH2
    • B7ZL60
    • C9J8I3
    • Q707N2
    • Q7Z441
    • Q8IUU0
    • Q9BQR8

    Protein attributes for SYT16 Gene

    Size:
    645 amino acids
    Molecular mass:
    72274 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).
    SequenceCaution:
    • Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT16 Gene

Post-translational modifications for SYT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT16 Gene

Domains & Families for SYT16 Gene

Gene Families for SYT16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYT16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q17RD7

UniProtKB/Swiss-Prot:

SYT16_HUMAN :
  • Belongs to the synaptotagmin family.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT16: view

Function for SYT16 Gene

Molecular function for SYT16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Phenotypes From GWAS Catalog for SYT16 Gene

Gene Ontology (GO) - Molecular Function for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT16: view
genes like me logo Genes that share phenotypes with SYT16: view

Animal Model Products

CRISPR Products

miRNA for SYT16 Gene

miRTarBase miRNAs that target SYT16

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYT16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT16 Gene

Localization for SYT16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT16 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SYT16 Gene

Pathways & Interactions for SYT16 Gene

SuperPathways for SYT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 NOT calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Pathways by source and SIGNOR curated interactions for SYT16 Gene

Drugs & Compounds for SYT16 Gene

No Compound Related Data Available

Transcripts for SYT16 Gene

mRNA/cDNA for SYT16 Gene

(18) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT16 Gene

Synaptotagmin XVI:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYT16
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SYT16 Gene

No ASD Table

Relevant External Links for SYT16 Gene

GeneLoc Exon Structure for
SYT16
ECgene alternative splicing isoforms for
SYT16

Expression for SYT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT16 Gene

This gene is overexpressed in Testis (x9.0), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SYT16 Gene:

SYT16

SOURCE GeneReport for Unigene cluster for SYT16 Gene:

Hs.404139

mRNA Expression by UniProt/SwissProt for SYT16 Gene:

Q17RD7-SYT16_HUMAN
Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for SYT16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SYT16: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT16 Gene

Orthologs for SYT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT16 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT16 33 34
  • 90.18 (n)
cow
(Bos Taurus)
Mammalia SYT16 33 34
  • 87.86 (n)
mouse
(Mus musculus)
Mammalia Syt16 33 16 34
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Syt16 33
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia SYT16 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT16 33 34
  • 65.05 (n)
lizard
(Anolis carolinensis)
Reptilia SYT16 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt16 33
  • 67.6 (n)
Str.10061 33
zebrafish
(Danio rerio)
Actinopterygii LOC558725 33
  • 62.93 (n)
syt16 34
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syt14 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2023.3 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for SYT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT16 Gene

ENSEMBL:
Gene Tree for SYT16 (if available)
TreeFam:
Gene Tree for SYT16 (if available)

Paralogs for SYT16 Gene

Paralogs for SYT16 Gene

(2) SIMAP similar genes for SYT16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT16: view

Variants for SYT16 Gene

Sequence variations from dbSNP and Humsavar for SYT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000026211 -- 62,071,841(+) AGGGC(C/T)AAATC intron-variant
rs1000028973 -- 62,069,055(+) CCTCC(A/C)AACGT intron-variant
rs1000036723 -- 62,055,916(+) AGCCT(C/T)AGTCT intron-variant, upstream-variant-2KB
rs1000039064 -- 61,907,347(+) TCATT(A/G)ATAAA intron-variant
rs1000041764 -- 61,986,339(+) ATTTA(A/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT16 Gene

Variant ID Type Subtype PubMed ID
nsv1303 CNV insertion 18451855
nsv456321 CNV loss 19166990
nsv564887 CNV loss 21841781

Variation tolerance for SYT16 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT16 Gene

Disorders for SYT16 Gene

Relevant External Links for SYT16

Genetic Association Database (GAD)
SYT16
Human Genome Epidemiology (HuGE) Navigator
SYT16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT16

No disorders were found for SYT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT16 Gene

Publications for SYT16 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M (Genomics 2001) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Synaptotagmin gene content of the sequenced genomes. (PMID: 15238157) Craxton M (BMC genomics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SYT16 Gene

Sources for SYT16 Gene

Content
Loading form....