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Aliases for SYT16 Gene

Aliases for SYT16 Gene

  • Synaptotagmin 16 2 3 5
  • Synaptotagmin XIV-Related Protein 3 4
  • Synaptotagmin 14-Like Protein 3 4
  • Chr14 Synaptotagmin 2 3
  • Synaptotagmin XVI 2 3
  • CHR14SYT 3 4
  • Strep14 3 4
  • SYT14L 3 4
  • Syt14r 3 4
  • Synaptotagmin XIV-Related 2
  • Synaptotagmin XIV-Like 2
  • CTD-2277K2.1 3
  • Yt14r 3

External Ids for SYT16 Gene

Previous HGNC Symbols for SYT16 Gene

  • SYT14L

Previous GeneCards Identifiers for SYT16 Gene

  • GC14P061533
  • GC14P062462
  • GC14P042626
  • GC14P061970

Summaries for SYT16 Gene

GeneCards Summary for SYT16 Gene

SYT16 (Synaptotagmin 16) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is SYT14.

UniProtKB/Swiss-Prot for SYT16 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT16 Gene

Genomics for SYT16 Gene

Regulatory Elements for SYT16 Gene

Enhancers for SYT16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYT16 on UCSC Golden Path with GeneCards custom track

Promoters for SYT16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT16 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT16 Gene

61,812,729 bp from pter
62,117,043 bp from pter
304,315 bases
Plus strand

Genomic View for SYT16 Gene

Genes around SYT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT16 Gene

Proteins for SYT16 Gene

  • Protein details for SYT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DZH2
    • B7ZL60
    • C9J8I3
    • Q707N2
    • Q7Z441
    • Q8IUU0
    • Q9BQR8

    Protein attributes for SYT16 Gene

    645 amino acids
    Molecular mass:
    72274 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).
    • Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYT16 Gene


neXtProt entry for SYT16 Gene

Proteomics data for SYT16 Gene at MOPED

Post-translational modifications for SYT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT16 Gene

Domains & Families for SYT16 Gene

Gene Families for SYT16 Gene

Protein Domains for SYT16 Gene


Suggested Antigen Peptide Sequences for SYT16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT16: view

Function for SYT16 Gene

Molecular function for SYT16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.

Gene Ontology (GO) - Molecular Function for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005543 phospholipid binding IEA --
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SYT16: view
genes like me logo Genes that share phenotypes with SYT16: view

Animal Model Products

miRNA for SYT16 Gene

miRTarBase miRNAs that target SYT16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT16 Gene

Localization for SYT16 Gene

Subcellular locations from

Jensen Localization Image for SYT16 Gene COMPARTMENTS Subcellular localization image for SYT16 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SYT16 Gene

Pathways & Interactions for SYT16 Gene

SuperPathways for SYT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048791 NOT calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Pathways by source and SIGNOR curated interactions for SYT16 Gene

Drugs & Compounds for SYT16 Gene

No Compound Related Data Available

Transcripts for SYT16 Gene

mRNA/cDNA for SYT16 Gene

(14) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT16 Gene

Synaptotagmin XVI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT16 Gene

No ASD Table

Relevant External Links for SYT16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT16 Gene

mRNA expression in normal human tissues for SYT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT16 Gene

This gene is overexpressed in Testis (x9.0), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.2).

SOURCE GeneReport for Unigene cluster for SYT16 Gene Hs.404139

mRNA Expression by UniProt/SwissProt for SYT16 Gene

Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with SYT16: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SYT16 Gene

Orthologs for SYT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYT16 35
  • 87.86 (n)
  • 84.47 (a)
SYT16 36
  • 85 (a)
(Canis familiaris)
Mammalia SYT16 35
  • 90.18 (n)
  • 88.53 (a)
SYT16 36
  • 88 (a)
(Mus musculus)
Mammalia Syt16 35
  • 84.33 (n)
  • 82.55 (a)
Syt16 16
Syt16 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Syt16 35
  • 82.71 (n)
  • 79.19 (a)
(Monodelphis domestica)
Mammalia SYT16 36
  • 67 (a)
(Pan troglodytes)
Mammalia SYT16 36
  • 99 (a)
(Gallus gallus)
Aves SYT16 35
  • 65.05 (n)
  • 58.13 (a)
SYT16 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SYT16 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10061 35
syt16 35
  • 67.6 (n)
  • 65.15 (a)
(Danio rerio)
Actinopterygii LOC558725 35
  • 62.93 (n)
  • 57.54 (a)
syt16 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt14 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea D2023.3 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for SYT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT16 Gene

Gene Tree for SYT16 (if available)
Gene Tree for SYT16 (if available)

Paralogs for SYT16 Gene

Paralogs for SYT16 Gene

(2) SIMAP similar genes for SYT16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT16: view

Variants for SYT16 Gene

Sequence variations from dbSNP and Humsavar for SYT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8019076 - 61,996,048(+) GGATG(C/T)TCAGA intron-variant, nc-transcript-variant, reference, missense
rs17099370 - 61,996,411(+) TGACC(A/G/T)CAAGT intron-variant, nc-transcript-variant, reference, missense
rs57214 -- 61,886,862(-) taagc(A/G)taact intron-variant
rs58511 -- 61,890,963(+) CCCTG(C/G)AGTGC intron-variant
rs102887 -- 61,929,514(+) TTTCA(C/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT16 Gene

Variant ID Type Subtype PubMed ID
nsv1303 CNV Insertion 18451855
nsv456321 CNV Loss 19166990

Variation tolerance for SYT16 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYT16 Gene

Disorders for SYT16 Gene

Relevant External Links for SYT16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT16 Gene

Publications for SYT16 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3 4 67
  2. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. (PMID: 24688116) Deelen J. … Slagboom P.E. (Hum. Mol. Genet. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. (PMID: 24478790) Lee J.H. … Mayeux R. (Front Genet 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for SYT16 Gene

Sources for SYT16 Gene