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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYT16 Gene

protein-coding GIFtS: 47
GCID: GC14P062462

synaptotagmin XVI

(Previous name: synaptotagmin XIV-like )
(Previous symbol: SYT14L)

Explore 1 disease affiliated with
SYT16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin XVI¹ ²		STREP14³ ⁵
SYT14L¹ ² ³		Synaptotagmin XIV-Like¹
CHR14SYT¹ ²		Chr14 Synaptotagmin²
Strep14¹ ²		Synaptotagmin-16¹
Yt14r¹		Syt14r¹
Synaptotagmin 14-Like Protein² ³		Chr14Syt³
Synaptotagmin XIV-Related Protein² ³		SYT14R³

External Ids:	HGNC: 23142¹	Entrez Gene: 83851²	Ensembl: ENSG00000139973⁷	OMIM: 610950⁵	UniProtKB: Q17RD7³

Export aliases for SYT16 gene to outside databases

Previous GC identifers: GC14P061533 GC14P042626

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYT16_HUMAN, Q17RD7

Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is

Ca(2+)-independent

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYT16 gene promoter:
AML1a Pax-2 Pax-2a Nkx2-5 Meis-1b AREB6 Nkx6-1 Pax-2b Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT16 promoter sequence

Search SABiosciences Chromatin IP Primers for SYT16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2 Ensembl cytogenetic band: 14q23.2 HGNC cytogenetic band: 14q23.2

SYT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT16 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P062462: view genomic region (about GC identifiers)

Start:	62,453,803 bp from pter	End:	62,568,431 bp from pter
Size:	114,629 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYT16_HUMAN, Q17RD7 (See protein sequence)

Recommended Name: Synaptotagmin-16

Size: 645 amino acids; 72274 Da

Subunit: Homodimer. Can also form heterodimers (By similarity)

Sequence caution: Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln;

Secondary accessions: B7ZL60 C9J8I3 Q707N2 Q7Z441 Q8IUU0 Q9BQR8

Alternative splicing: 3 isoforms: Q17RD7-1 Q17RD7-2 Q17RD7-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYT16: NX_Q17RD7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q17RD7

SYT16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_114120.2

ENSEMBL proteins:

ENSP00000394700 ENSP00000451035 ENSP00000388023

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYT16 for domains About GeneDecksing

3 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR018029 C2_membr_targeting

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q17RD7

ProtoNet protein and cluster: Q17RD7

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: SYT16_HUMAN, Q17RD7

Similarity: Belongs to the synaptotagmin family

Similarity: Contains 2 C2 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SYT16_HUMAN, Q17RD7

Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is

Ca(2+)-independent

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005543	phospholipid binding	IEA	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

SYT16 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SYT16:

Synthetic lethal with c-Myc af

Animal Models:

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		SwitchGear 3'UTR luciferase reporter plasmid: SYT16 3' UTR sequence

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYT16

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SYT16 (Q17RD7³ ENSP00000394700⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SYT14	Q8NB59³, ENSP00000418901⁴	I2D: score=2 STRING: ENSP00000418901
--	ENSP00000388949⁴	STRING: ENSP00000388949

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for SYT16
Search CenterWatch for drugs/clinical trials and news about SYT16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYT16 gene:

NM_031914.2

Unigene Cluster for SYT16:

Synaptotagmin XVI

Hs.404139 [show with all ESTs]

Unigene Representative Sequence: AJ617628

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000430451(uc001xfu.1) ENST00000555409(uc010tse.1) ENST00000446982(uc010tsd.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT16
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT16:
		hsa-miR-299-5p hsa-miR-374c hsa-miR-587 hsa-miR-4311 hsa-miR-655 hsa-miR-3658 hsa-miR-3647-3p
		SwitchGear 3'UTR luciferase reporter plasmid: SYT16 3' UTR sequence

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Additional cDNA sequence:

AB102949.1 AJ303367.1 AJ617628.1 AK302919.1 BC040924.1 BC117363.1 BC143598.1

4 DOTS entries:

DT.101978522 DT.97803587 DT.100691869 DT.120753215

7 AceView cDNA sequences:

BM927053 NM_031914 AB102949 BC040924 AJ303367 AJ617628 AI970973

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYT16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTTTTAA

About this image

SYT16 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYT16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYT16

SOURCE GeneReport for Unigene cluster: Hs.404139

UniProtKB/Swiss-Prot: SYT16_HUMAN, Q17RD7

Tissue specificity: Expressed in brain

SABiosciences Custom PCR Arrays for SYT16

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYT16 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SYT16¹	synaptotagmin XVI	63.8(n) 57.39(a)		423516 XM_421415.3 XP_421415.3
lizard (Anolis carolinensis)	Reptilia	SYT16⁶ --	--	71(a) 23(a)	1 ↔ 1 possible ortholog	1(3041311-3069811) GL343721.1(188179-190957)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10061²	Transcribed sequence with weak similarity to protein more	79.31(n)		141992148
zebrafish (Danio rerio)	Actinopterygii	LOC558725¹	novel protein similar to H.sapiens SYT16, synaptotagmin more	65.41(n) 60.76(a)		558725 XM_003199742.1 XP_003199790.1
fruit fly (Drosophila melanogaster)	Insecta	Syt14⁶	Synaptotagmin 14	29(a)	1 → many	3R(141310-144791)
worm (Caenorhabditis elegans)	Secernentea	snt-6⁶	SyNapTotagmin family member (snt-6)	17(a)	possible ortholog	II(745469-750171)

ENSEMBL Gene Tree for SYT16 (if available)
TreeFam Gene Tree for SYT16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYT16 gene

SYT14²

2 SIMAP similar genes for SYT16 using alignment to 2 protein entries: SYT16_HUMAN (see all proteins):

SYT14L SYT14

SYT16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141757200^1,2		--	62460552(+)	`GGTGTC/TGTTTT`	1	--	us2k¹		0	--	--	--	--
rs186430629^1,2		--	62460598(+)	`TCACTA/GTGTGC`	1	--	us2k¹		0	--	--	--	--
rs78008064^1,2	F	--	62460667(+)	`TCCAGG/AGAGCC`	1	--	us2k¹		1		WA	118
rs79479454^1,2	C	--	62460746(+)	`ATTGAA/GTCTGG`	1	--	us2k¹		0	--	--	--	--
rs114431285^1,2		--	62460764(+)	`GAGCAT/CATGAA`	1	--	us2k¹		1		WA	118
rs190849463^1,2		--	62460765(+)	`AGCATA/GTGAAG`	1	--	us2k¹		0	--	--	--	--
rs11844687^1,2	C,F,H	--	62460775(+)	`GCGAAC/TTAGGT`	1	--	us2k¹		6		NS EA CSA WA	540
rs182330994^1,2		--	62461264(+)	`TAATTG/TAAATG`	1	--	us2k¹		0	--	--	--	--
rs185174909^1,2		--	62461274(+)	`GTAGGA/GATGGG`	1	--	us2k¹		0	--	--	--	--
rs191501708^1,2		--	62461413(+)	`GGGGAA/TATGTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYT16 (62453803 - 62568431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYT16: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT16

DNA2.0 Custom Variant and Variant Library Synthesis for SYT16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYT16 for disorders           About GeneDecksing

OMIM gene information: 610950    OMIM disorders: --

1 disease for SYT16:    About MalaCards

neuronitis

Human Genome Epidemiology (HuGE) Navigator: SYT16 (1 document)

Export disorders for SYT16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYT16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYT16)

Utopia: connect your pdf to the dynamic
world of online information

Genomic analysis of synaptotagmin genes. (PubMed id 11543631)^{1, 2, 3} Craxton M.A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Synaptotagmin gene content of the sequenced genomes. (PubMed id 15238157)^{1, 2} Craxton M.A. (2004)
Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. (PubMed id 12801916)^{1, 2} Fukuda M. (2003)
A genome-wide association study of self-rated health. (PubMed id 20707712)¹ Mosing M.A....Martin N.G. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2B. (PubMed id 16946482)¹ Montes M....Robert J.J. (2006)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83851	HGNC: 23142	AceView: SYT14L	Ensembl:ENSG00000139973	euGenes: HUgn83851
ECgene: SYT16	H-InvDB: SYT16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYT16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYT16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYT16 gene:
Search GeneIP for patents involving SYT16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for SYT16
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYT16
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	GenScript Custom Purified and Recombinant Proteins Services for SYT16		GenScript cDNA clones with any tag delivered in your preferred vector for SYT16
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT16

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYT16

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYT16 gene at Home site.

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SYT16 Gene

synaptotagmin XVI

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SYT16 Gene

synaptotagmin XVI

Aliasesfor SYT16 gene

Summariesfor SYT16 gene

Genomic Viewsfor SYT16 gene

Proteinsfor SYT16 gene

Protein Domains /Familiesfor SYT16 gene

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for SYT16 gene

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for SYT16 gene

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for SYT16 gene

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for SYT16 gene

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for SYT16 gene

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for SYT16 gene

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for SYT16 gene

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