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Aliases for SYT16 Gene

Aliases for SYT16 Gene

  • Synaptotagmin XVI 2 3
  • Strep14 3 4 6
  • Synaptotagmin XIV-Related Protein 3 4
  • Synaptotagmin 14-Like Protein 3 4
  • Chr14 Synaptotagmin 2 3
  • CHR14SYT 3 4
  • Syt14r 3 4
  • SYT14L 3 4
  • Synaptotagmin XIV-Related 2
  • Synaptotagmin XIV-Like 2
  • Synaptotagmin-16 3
  • Yt14r 3

External Ids for SYT16 Gene

Previous HGNC Symbols for SYT16 Gene

  • SYT14L

Previous GeneCards Identifiers for SYT16 Gene

  • GC14P061533
  • GC14P062462
  • GC14P042626

Summaries for SYT16 Gene

GeneCards Summary for SYT16 Gene

SYT16 (Synaptotagmin XVI) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and phospholipid binding.

UniProtKB/Swiss-Prot for SYT16 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT16 Gene

Genomics for SYT16 Gene

Regulatory Elements for SYT16 Gene

Genomic Location for SYT16 Gene

61,970,235 bp from pter
62,112,550 bp from pter
142,316 bases
Plus strand

Genomic View for SYT16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT16 Gene

Proteins for SYT16 Gene

  • Protein details for SYT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DZH2
    • B7ZL60
    • C9J8I3
    • Q707N2
    • Q7Z441
    • Q8IUU0
    • Q9BQR8

    Protein attributes for SYT16 Gene

    645 amino acids
    Molecular mass:
    72274 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).
    • Sequence=CAE85114.1; Type=Erroneous termination; Positions=72; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYT16 Gene


neXtProt entry for SYT16 Gene

Proteomics data for SYT16 Gene at MOPED

Post-translational modifications for SYT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SYT16 Gene

Domains for SYT16 Gene

Gene Families for SYT16 Gene

  • SYT :Synaptotagmins

Protein Domains for SYT16 Gene


Suggested Antigen Peptide Sequences for SYT16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q17RD7
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT16: view

Function for SYT16 Gene

Molecular function for SYT16 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent

Gene Ontology (GO) - Molecular Function for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding --
GO:0005544 NOT calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT16: view

Phenotypes for SYT16 Gene

GenomeRNAi human phenotypes for SYT16:
genes like me logo Genes that share phenotypes with SYT16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SYT16 Gene

Localization for SYT16 Gene

Subcellular locations from

Jensen Localization Image for SYT16 Gene COMPARTMENTS Subcellular localization image for SYT16 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYT16 Gene

Pathways for SYT16 Gene

SuperPathways for SYT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 NOT calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT16: view

No data available for Pathways by source for SYT16 Gene

Transcripts for SYT16 Gene

mRNA/cDNA for SYT16 Gene

(14) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT16 Gene

Synaptotagmin XVI:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT16 Gene

No ASD Table

Relevant External Links for SYT16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT16 Gene

mRNA expression in normal human tissues for SYT16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT16 Gene

This gene is overexpressed in Testis (9.0), Brain - Cortex (4.7), and Brain - Anterior cingulate cortex (BA24) (4.2).

SOURCE GeneReport for Unigene cluster for SYT16 Gene Hs.404139

mRNA Expression by UniProt/SwissProt for SYT16 Gene

Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with SYT16: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for SYT16 Gene

Orthologs for SYT16 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYT16 35
  • 87.86 (n)
  • 84.47 (a)
SYT16 36
  • 85 (a)
(Canis familiaris)
Mammalia SYT16 35
  • 90.18 (n)
  • 88.53 (a)
SYT16 36
  • 88 (a)
(Mus musculus)
Mammalia Syt16 35
  • 84.33 (n)
  • 82.55 (a)
Syt16 16
Syt16 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Syt16 35
  • 82.71 (n)
  • 79.19 (a)
(Monodelphis domestica)
Mammalia SYT16 36
  • 67 (a)
(Pan troglodytes)
Mammalia SYT16 36
  • 99 (a)
(Gallus gallus)
Aves SYT16 35
  • 65.05 (n)
  • 58.13 (a)
SYT16 36
  • 85 (a)
(Anolis carolinensis)
Reptilia SYT16 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10061 35
syt16 35
  • 67.6 (n)
  • 65.15 (a)
(Danio rerio)
Actinopterygii LOC558725 35
  • 62.93 (n)
  • 57.54 (a)
syt16 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt14 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea D2023.3 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for SYT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT16 Gene

Gene Tree for SYT16 (if available)
Gene Tree for SYT16 (if available)

Paralogs for SYT16 Gene

Selected SIMAP similar genes for SYT16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT16: view

No data available for Paralogs for SYT16 Gene

Variants for SYT16 Gene

Sequence variations from dbSNP and Humsavar for SYT16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1104821 -- 62,100,188(-) TAATG(C/T)TTCAT intron-variant
rs1254910 -- 62,036,274(+) GAAAC(A/G)TGAGG intron-variant
rs1254911 -- 62,037,163(+) GGTCC(A/C/G)CACTT intron-variant
rs1254912 -- 62,037,722(+) CTGAA(A/C)GAACC intron-variant
rs1254913 -- 62,038,015(+) TAAGC(A/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT16 Gene

Variant ID Type Subtype PubMed ID
nsv1303 CNV Insertion 18451855
nsv456321 CNV Loss 19166990

Relevant External Links for SYT16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT16 Gene

Disorders for SYT16 Gene

Relevant External Links for SYT16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SYT16 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SYT16 Gene

Publications for SYT16 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3 4
  2. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. (PMID: 12801916) Fukuda M. (J. Biochem. 2003) 3 4
  3. Synaptotagmin gene content of the sequenced genomes. (PMID: 15238157) Craxton M.A. (BMC Genomics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SYT16 Gene

Sources for SYT16 Gene

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