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Aliases for SYT15 Gene

Aliases for SYT15 Gene

  • Synaptotagmin 15 2 3 5
  • Synaptotagmin XV 2 3 4
  • Chr10Syt 3 4
  • SytXV 3 4
  • Chr10 Synaptotagmin 3
  • Synaptotagmin XV-A 3

External Ids for SYT15 Gene

Previous GeneCards Identifiers for SYT15 Gene

  • GC10U900263
  • GC10M046339
  • GC10M046378
  • GC10M046955
  • GC10M042810

Summaries for SYT15 Gene

Entrez Gene Summary for SYT15 Gene

  • This gene encodes a member of the Synaptotagmin (Syt) family of membrane trafficking proteins. Members of this family contain a transmembrane region and a C-terminal-type tandem C2 domain. Unlike related family members, the encoded protein may be involved in membrane trafficking in non-neuronal tissues. Two trancript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYT15 Gene

SYT15 (Synaptotagmin 15) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is LOC102724488.

UniProtKB/Swiss-Prot for SYT15 Gene

  • May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT15 Gene

Genomics for SYT15 Gene

Regulatory Elements for SYT15 Gene

Enhancers for SYT15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYT15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT15 Gene

46,578,217 bp from pter
46,595,194 bp from pter
16,978 bases
Plus strand

Genomic View for SYT15 Gene

Genes around SYT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT15 Gene

Proteins for SYT15 Gene

  • Protein details for SYT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A5D6W8
    • Q5VY53
    • Q5VY55
    • Q7Z439
    • Q7Z440

    Protein attributes for SYT15 Gene

    421 amino acids
    Molecular mass:
    47375 Da
    Quaternary structure:
    • Homodimer.
    • Homodimer.

    Alternative splice isoforms for SYT15 Gene


neXtProt entry for SYT15 Gene

Proteomics data for SYT15 Gene at MOPED

Post-translational modifications for SYT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT15 Gene

No data available for DME Specific Peptides for SYT15 Gene

Domains & Families for SYT15 Gene

Gene Families for SYT15 Gene

Protein Domains for SYT15 Gene

Suggested Antigen Peptide Sequences for SYT15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.
  • Belongs to the synaptotagmin family.
  • Neither C2 domains mediates Ca(2+)-dependent or -independent phospholipid binding.
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT15: view

Function for SYT15 Gene

Molecular function for SYT15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.

Gene Ontology (GO) - Molecular Function for SYT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
genes like me logo Genes that share ontologies with SYT15: view
genes like me logo Genes that share phenotypes with SYT15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT15 Gene

Localization for SYT15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT15 Gene

Isoform 1: Cell membrane; Single-pass type III membrane protein.
Isoform 2: Cell membrane; Single-pass type III membrane protein.
Isoform 4: Cell membrane; Single-pass type III membrane protein.

Subcellular locations from

Jensen Localization Image for SYT15 Gene COMPARTMENTS Subcellular localization image for SYT15 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 2
vacuole 2

No data available for Gene Ontology (GO) - Cellular Components for SYT15 Gene

Pathways & Interactions for SYT15 Gene

SuperPathways for SYT15 Gene

No Data Available

Interacting Proteins for SYT15 Gene

Gene Ontology (GO) - Biological Process for SYT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT15: view

No data available for Pathways by source and SIGNOR curated interactions for SYT15 Gene

Drugs & Compounds for SYT15 Gene

No Compound Related Data Available

Transcripts for SYT15 Gene

Unigene Clusters for SYT15 Gene

Synaptotagmin XV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT15 Gene

No ASD Table

Relevant External Links for SYT15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT15 Gene

mRNA expression in normal human tissues for SYT15 Gene

Protein differential expression in normal tissues from HIPED for SYT15 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYT15 Gene

SOURCE GeneReport for Unigene cluster for SYT15 Gene Hs.696346

genes like me logo Genes that share expression patterns with SYT15: view

Protein tissue co-expression partners for SYT15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYT15 Gene

Orthologs for SYT15 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYT15 35
  • 84.83 (n)
  • 80.98 (a)
SYT15 36
  • 78 (a)
(Canis familiaris)
Mammalia SYT15 35
  • 77.52 (n)
  • 67.7 (a)
SYT15 36
  • 58 (a)
(Mus musculus)
Mammalia Syt15 35
  • 82.93 (n)
  • 78.47 (a)
Syt15 16
Syt15 36
  • 79 (a)
(Pan troglodytes)
Mammalia SYT15 35
  • 99.13 (n)
  • 98.57 (a)
SYT15 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Syt15 35
  • 81.98 (n)
  • 77.75 (a)
(Monodelphis domestica)
Mammalia SYT15 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SYT15 36
  • 65 (a)
(Gallus gallus)
Aves SYT15 35
  • 64.77 (n)
  • 63.57 (a)
SYT15 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SYT15 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496499 35
  • 61.21 (n)
  • 60.1 (a)
Str.9057 35
(Danio rerio)
Actinopterygii syt15 35
  • 57.3 (n)
  • 46.49 (a)
syt15 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sytbeta 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea snt-6 36
  • 23 (a)
Species with no ortholog for SYT15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT15 Gene

Gene Tree for SYT15 (if available)
Gene Tree for SYT15 (if available)

Paralogs for SYT15 Gene

Paralogs for SYT15 Gene

(13) SIMAP similar genes for SYT15 Gene using alignment to 3 proteins: Pseudogenes for SYT15 Gene

genes like me logo Genes that share paralogs with SYT15: view

Variants for SYT15 Gene

Sequence variations from dbSNP and Humsavar for SYT15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12450 -- 46,576,763(-) tagcc(A/G)tctct upstream-variant-2KB
rs3120445 -- 46,578,314(+) CGGCG(C/T)GGCCC upstream-variant-2KB
rs3127789 -- 46,581,214(-) TATCT(C/T)ACCCT intron-variant
rs3127790 -- 46,580,855(-) CAAGT(C/G)AATGG intron-variant
rs3127791 -- 46,580,667(-) ATTTG(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT15 Gene

Variant ID Type Subtype PubMed ID
dgv252e1 CNV Complex 17122850
dgv253e1 CNV Complex 17122850
esv2750898 CNV Loss 17911159
dgv254e1 CNV Complex 17122850
nsv516485 CNV Gain+Loss 19592680
esv2750899 CNV Gain 17911159
nsv895114 CNV Gain 21882294
esv34875 CNV Gain 17911159
nsv510991 OTHER Complex 20534489
dgv256e1 CNV Complex 17122850
dgv257e1 CNV Complex 17122850
esv22204 CNV Gain+Loss 19812545
nsv895118 CNV Gain 21882294
dgv258e1 CNV Complex 17122850
nsv8636 CNV Gain+Loss 18304495
nsv436102 CNV Deletion 17901297
nsv7203 OTHER Inversion 18451855
esv2736152 CNV Deletion 23290073
dgv652n71 CNV Loss 21882294
dgv653n71 CNV Gain 21882294
dgv654n71 CNV Gain 21882294
dgv655n71 CNV Loss 21882294
nsv895128 CNV Gain+Loss 21882294
dgv656n71 CNV Gain 21882294
esv2736163 CNV Deletion 23290073
dgv8n68 CNV Gain 17160897
essv21763 CNV CNV 17122850
dgv259e1 CNV Complex 17122850
dgv260e1 CNV Complex 17122850
dgv657n71 CNV Gain 21882294
dgv658n71 CNV Gain 21882294
nsv895135 CNV Loss 21882294
nsv895145 CNV Gain 21882294
dgv659n71 CNV Gain 21882294
dgv660n71 CNV Gain 21882294
dgv661n71 CNV Gain 21882294
dgv22e55 CNV Gain 17911159
dgv261e1 CNV Complex 17122850
dgv262e1 CNV Complex 17122850
dgv23e55 CNV Loss 17911159
dgv24e55 CNV Gain 17911159
nsv438171 CNV Loss 16468122
dgv147n67 CNV Gain 20364138
nsv820817 CNV Duplication 20802225
esv2632472 CNV Gain 19546169
nsv482144 CNV Gain 20164927
dgv662n71 CNV Loss 21882294
dgv663n71 CNV Gain+Loss 21882294

Variation tolerance for SYT15 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYT15 Gene

Disorders for SYT15 Gene

Relevant External Links for SYT15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYT15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT15 Gene

Publications for SYT15 Gene

  1. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3 4 67
  2. Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV. (PMID: 12788067) Fukuda M. (Biochem. Biophys. Res. Commun. 2003) 3 23
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SYT15 Gene

Sources for SYT15 Gene