SYT14 Gene

Aliases
for SYT14 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC01P206750 GC01P207190 GC01P206514 GC01P208178 GC01P180796

Summaries
for SYT14 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SYT14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_004487.20  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: SYT14 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT14

SYT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P210112:  view genomic region     (about GC identifiers)

Proteins
for SYT14 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SYT14: NX_Q8NB59

Explore proteomics data for SYT14 at MOPED

Post-translational modifications: 

SYT14 Human Recombinant Protein Products:

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Domains /
Families
for SYT14 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8NB59

Find genes that share domains with SYT14           About GenesLikeMe

Function
for SYT14 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for SYT14

miRNA Products:		miRTarBase miRNAs that target SYT14: hsa-mir-335-5p (MIRT016916), hsa-mir-132-3p (MIRT021754)
		Block miRNA regulation of human, mouse, rat SYT14 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SYT14 (see all 61):
		hsa-miR-579 hsa-miR-142-5p hsa-miR-3685 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-29a hsa-miR-139-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SYT14 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat SYT14

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SYT14

Clone Products:		OriGene clones in human, mouse for SYT14 (see all 23) OriGene ORF clones in mouse, rat for SYT14 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SYT14 (NM_001146264)
		Browse Sino Biological Human cDNA Clones
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT14

Localization
for SYT14 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	2
cytosol	1
endoplasmic reticulum	1
mitochondrion	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for SYT14 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for SYT14 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for SYT14 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SYT14 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SYT14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAAAAACAG

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Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
Human embryonic stem cells (family)

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SYT14
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT14
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		QuantiFast Probe-based Assays in human, mouse, rat SYT14

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT14

Orthologs
for SYT14 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SYT14 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SYT14 gene

SYT16²  

3 SIMAP similar genes for SYT14 using alignment to 3 protein entries:     SYT14_HUMAN (see all proteins):

SYT14L    TUBA1C    SYT16

Find genes that share paralogs with SYT14           About GenesLikeMe


1 Pseudogenes.org Pseudogene for SYT14
PGOHUM00000250714

Genomic Variants
for SYT14 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SYT14 (see all 4177)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0666644		Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11)4	--	see VAR_066664	2	G D	mis4		0	--	--	--	--
rs667367371,2	C	--	210109845(+)	ACATGAGTCTCCTG GACAAATA/-AGTCT	6	--	us2k1		1		NA	2
rs748712381,2	F	--	210110907(+)	GTGAGT/AGAGAG	6	--	us2k1		3		NA CSA	6
rs2019609261,2	C	--	210115706(+)	ACCCC-/CCCCCCCC	6	--	int1		0	--	--	--	--
rs588067921,2	C	--	210116854(+)	AAAAA-/AAGAGAA	6	--	int1		1		NA	2
rs1121688031,2	F	--	210120089(+)	CAACAG/TATTTT	6	--	int1		1		CSA	2
rs586492621,2	C,F	--	210129627(+)	CCAAACAAA/-           TAATG	6	--	int1		2		NA CSA	4
rs356965481,2	C	--	210132766(+)	TACAG-/GCGTGA	6	--	int1		0	--	--	--	--
rs717411741,2	C	--	210142072(+)	ATTTC-/TTTTTT	6	--	int1		0	--	--	--	--
rs1136495121,2	C	--	210151539(-)	AGAGAG/TCAAGG	6	--	int1		4		WA CSA	6

HapMap Linkage Disequilibrium report for SYT14 (210111538 - 210337636 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SYT14 (see all 18):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2722251	CNV	Deletion	23290073
esv4684	CNV	Deletion	18987735
esv2663015	CNV	Deletion	23128226
esv2657303	CNV	Deletion	23128226
esv2399148	CNV	Deletion	18987734
esv1564426	CNV	Deletion	17803354
esv2663327	CNV	Deletion	23128226
esv2722262	CNV	Deletion	23290073
esv2561272	CNV	Deletion	19546169
nsv4365	CNV	Insertion	18451855

Human Gene Mutation Database (HGMD): SYT14

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SYT14

DNA2.0 Custom Variant and Variant Library Synthesis for SYT14

Disorders / Diseases
for SYT14 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for SYT14 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SYT14 gene, integrated from 10 sources (see all 14): (articles sorted by number of sources associating them with SYT14)

Utopia: connect your pdf to the dynamic world of online information

1. Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation. (PubMed id 21835308)^{1, 2} Doi H....Matsumoto N. (Am. J. Hum. Genet. 2011)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
5. Synaptotagmin gene content of the sequenced genomes. (PubMed id 15238157)^{1, 2} Craxton M.A. (BMC Genomics 2004)
6. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. (PubMed id 12801916)^{1, 2} Fukuda M. (J. Biochem. 2003)
7. Recent advances in the genetics of cerebellar ataxias. (PubMed id 22527681)¹ Sailer A. and Houlden H. (Curr Neurol Neurosci Rep 2012)
8. Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities. (PubMed id 17304550)¹ Quintero-Rivera F....Ligon A.H. (Am. J. Med. Genet. A 2007)
9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)⁴ Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
10. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)⁴ Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)

External Searches for SYT14 gene

Genome Databases showing SYT14 gene

Other Databases showing SYT14 gene

Specialized Databases showing SYT14 gene

Products
for SYT14 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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