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SYT14 Gene

protein-coding   GIFtS: 52
GCID: GC01P210112

Synaptotagmin XIV

  See SYT14-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin XIV1 2 3
SCAR112 5
synaptotagmin-142
sytXIV2
SytXIV3

External Ids:    HGNC: 231431   Entrez Gene: 2559282   Ensembl: ENSG000001434697   OMIM: 6109495   UniProtKB: Q8NB593   

Export aliases for SYT14 gene to outside databases

Previous GC identifers: GC01P206750 GC01P207190 GC01P206514 GC01P208178 GC01P180796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT14 Gene:
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that
mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent
synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and
a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this
gene is located on the long arm of chromosome 4. (provided by RefSeq, Dec 2011)

GeneCards Summary for SYT14 Gene:
SYT14 (synaptotagmin XIV) is a protein-coding gene. Diseases associated with SYT14 include spinocerebellar ataxia, autosomal recessive 11. GO annotations related to this gene include phospholipid binding and protein homodimerization activity. An important paralog of this gene is SYT16.

UniProtKB/Swiss-Prot: SYT14_HUMAN, Q8NB59
Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is
Ca(2+)-independent

Gene Wiki entry for SYT14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT14 gene promoter:
         TBP   HTF   HSF1 (long)   MIF-1   Cdc5   C/EBPalpha   Evi-1   HSF1short   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT14 promoter sequence
   Search Chromatin IP Primers for SYT14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32.2

SYT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P210112:  view genomic region     (about GC identifiers)

Start:
210,111,538 bp from pter      End:
210,337,636 bp from pter
Size:
226,099 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for SYT14

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYT14_HUMAN, Q8NB59 (See protein sequence)
Recommended Name: Synaptotagmin-14  
Size: 555 amino acids; 62287 Da
Subunit: Homodimer. Can also form heterodimers (By similarity)
Secondary accessions: B1AJU0 B1AJU1 F5H426 Q5THX7 Q707N3 Q707N4 Q707N5 Q707N6 Q707N7
Alternative splicing: 7 isoforms:  Q8NB59-1   Q8NB59-2   Q8NB59-3   Q8NB59-4   Q8NB59-5   Q8NB59-6   Q8NB59-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYT14: NX_Q8NB59

Explore proteomics data for SYT14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001139733.1  NP_001139734.1  NP_001139736.1  NP_001242935.1  NP_694994.2  

    ENSEMBL proteins: 
     ENSP00000355986   ENSP00000418901   ENSP00000355982   ENSP00000389039   ENSP00000442891  
     ENSP00000445837   ENSP00000437423  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    2 InterPro protein domains:
     IPR028696 SYT14
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q8NB59

    ProtoNet protein and cluster: Q8NB59

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT14_HUMAN, Q8NB59
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Find genes that share domains with SYT14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT14_HUMAN, Q8NB59
    Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is
    Ca(2+)-independent

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with SYT14           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT14:
     Increased mitotic index  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT14
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    miRNA
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    miRTarBase miRNAs that target SYT14:
    hsa-mir-335-5p (MIRT016916), hsa-mir-132-3p (MIRT021754)

    Block miRNA regulation of human, mouse, rat SYT14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT14 (see all 61):
    hsa-miR-579 hsa-miR-142-5p hsa-miR-3685 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-29a hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidSYT14 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT14_HUMAN, Q8NB59: Membrane; Single-pass type III membrane protein. Note=Localized in perinuclear and
    submembranous regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SYT14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT14
    Interactions:

        GeneGlobe Interaction Network for SYT14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for SYT14 (Q8NB593 ENSP000004189014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYT16Q17RD73, ENSP000003947004I2D: score=2 STRING: ENSP00000394700
    ATG13O751433I2D: score=1 
    MKNK1Q9BUB53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IEA--

    Find genes that share ontologies with SYT14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYT14 gene (5 alternative transcripts): 
    NM_001146261.2  NM_001146262.2  NM_001146264.2  NM_001256006.1  NM_153262.3  

    Unigene Cluster for SYT14:

    Synaptotagmin XIV
    Hs.658866  [show with all ESTs]
    Unigene Representative Sequence: NM_001256006
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367019 ENST00000472886 ENST00000271745 ENST00000367015 ENST00000469604
    ENST00000422431(uc001hhs.4 uc010psn.2) ENST00000534859(uc010psp.2)
    ENST00000399639(uc001hht.4 uc009xcv.3) ENST00000537238(uc001hhu.4 uc010pso.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat SYT14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT14 (see all 61):
    hsa-miR-579 hsa-miR-142-5p hsa-miR-3685 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-29a hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidSYT14 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB102948.1 AJ617623.1 AJ617624.1 AJ617625.1 AJ617626.1 AJ617627.1 AK091517.1 BC130323.1 
    BC144154.1 BC144155.1 BC144157.1 NR_027459.2 

    6 DOTS entries:

    DT.99998386  DT.121450649  DT.91812582  DT.101981302  DT.101981300  DT.75108589 

    11 AceView cDNA sequences:

    BX281958 BX489670 AI808504 AJ617625 AJ617624 AJ617623 AX747035 AB102948 
    AK091517 NM_153262 AJ617626 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SYT14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:                                -               


    ECgene alternative splicing isoforms for SYT14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAAACAG
    SYT14 Expression
    About this image


    SYT14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    SYT14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658866

    UniProtKB/Swiss-Prot: SYT14_HUMAN, Q8NB59
    Tissue specificity: Highly expressed in fetal and adult brain tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYT14 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt141 , 5 synaptotagmin XIV1, 5 88.95(n)1
    93.87(a)1
      1 (97.55 cM)5
    3293241  NM_181546.21  NP_853524.11 
     1928973075 
    chicken
    (Gallus gallus)
    Aves SYT141 synaptotagmin XIV 87.76(n)
    93.5(a)
      428566  XM_426122.4  XP_426122.4 
    lizard
    (Anolis carolinensis)
    Reptilia SYT146
    synaptotagmin XIV
    86(a)
    1 ↔ 1
    1(236968894-237084075)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia syt141 synaptotagmin XIV 76.76(n)
    84.22(a)
      100491102  XM_002934679.2  XP_002934725.2 
    zebrafish
    (Danio rerio)
    Actinopterygii syt14a1 synaptotagmin XIVa 67.96(n)
    76.02(a)
      564702  XM_688032.5  XP_693124.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syt146
    Synaptotagmin 14
    30(a)
    1 → many
    3R(141310-144791)
    worm
    (Caenorhabditis elegans)
    Secernentea D2023.36
    Protein D2023.3, isoform b (D2023.3) mRNA, complet...
    26(a)
    1 → many
    V(11802105-11812012) WBGene00008407


    ENSEMBL Gene Tree for SYT14 (if available)
    TreeFam Gene Tree for SYT14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT14 gene
    SYT162  
    3 SIMAP similar genes for SYT14 using alignment to 3 protein entries:     SYT14_HUMAN (see all proteins):
    SYT14L    TUBA1C    SYT16

    Find genes that share paralogs with SYT14           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SYT14
    PGOHUM00000250714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT14 (see all 4177)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0666644
    Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11)4--see VAR_0666642 G D mis40--------
    rs667367371,2
    C--210109845(+) ACATGAGTCTCCTG
    GACAAATA
    /-
    AGTCT
    6 -- us2k11Minor allele frequency- -:0.50NA 2
    rs748712381,2
    F--210110907(+) GTGAGT/AGAGAG 6 -- us2k13Minor allele frequency- A:0.50NA CSA 6
    rs2019609261,2
    C--210115706(+) ACCCC-/CCCCCCCC 6 -- int10--------
    rs588067921,2
    C--210116854(+) AAAAA-/AAGAGAA 6 -- int11Minor allele frequency- AA:0.00NA 2
    rs1121688031,2
    F--210120089(+) CAACAG/TATTTT 6 -- int11Minor allele frequency- T:0.50CSA 2
    rs586492621,2
    C,F--210129627(+) CCAAACAAA/-  
            
    TAATG
    6 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs356965481,2
    C--210132766(+) TACAG-/GCGTGA 6 -- int10--------
    rs717411741,2
    C--210142072(+) ATTTC-/TTTTTT 6 -- int10--------
    rs1136495121,2
    C--210151539(-) AGAGAG/TCAAGG 6 -- int14Minor allele frequency- T:0.17WA CSA 6

    HapMap Linkage Disequilibrium report for SYT14 (210111538 - 210337636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYT14 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722251CNV Deletion23290073
    esv4684CNV Deletion18987735
    esv2663015CNV Deletion23128226
    esv2657303CNV Deletion23128226
    esv2399148CNV Deletion18987734
    esv1564426CNV Deletion17803354
    esv2663327CNV Deletion23128226
    esv2722262CNV Deletion23290073
    esv2561272CNV Deletion19546169
    nsv4365CNV Insertion18451855

    Human Gene Mutation Database (HGMD): SYT14
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT14
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610949   
    OMIM disorders: 614229  
    UniProtKB/Swiss-Prot: SYT14_HUMAN, Q8NB59
  • Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) [MIM:614229]: Spinocerebellar ataxia is a
    clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination
    of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum
    with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for SYT14:    
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    spinocerebellar ataxia, autosomal recessive 11


    Find genes that share disorders with SYT14           About GenesLikeMe

    Genetic Association Database (GAD): SYT14
    Human Genome Epidemiology (HuGE) Navigator: SYT14 (1 document)

    Export disorders for SYT14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT14 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SYT14)
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    1. Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation. (PubMed id 21835308)1, 2 Doi H....Matsumoto N. (Am. J. Hum. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Synaptotagmin gene content of the sequenced genomes. (PubMed id 15238157)1, 2 Craxton M.A. (BMC Genomics 2004)
    6. Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans. (PubMed id 12801916)1, 2 Fukuda M. (J. Biochem. 2003)
    7. Recent advances in the genetics of cerebellar ataxias. (PubMed id 22527681)1 Sailer A. and Houlden H. (Curr Neurol Neurosci Rep 2012)
    8. Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities. (PubMed id 17304550)1 Quintero-Rivera F....Ligon A.H. (Am. J. Med. Genet. A 2007)
    9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    10. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255928 HGNC: 23143 AceView: SYT14 Ensembl:ENSG00000143469 euGenes: HUgn255928
    ECgene: SYT14 H-InvDB: SYT14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYT14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYT14 gene:
    Search GeneIP for patents involving SYT14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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