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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT13 Gene

protein-coding   GIFtS: 52
GCID: GC11M045261

Synaptotagmin XIII

  Search for SYT13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptotagmin XIII1 2 3
KIAA14273 5
synaptotagmin-132
sytXIII2
SytXIII3

External Ids:    HGNC: 149621   Entrez Gene: 575862   Ensembl: ENSG000000195057   OMIM: 6077165   UniProtKB: Q7L8C53   

Export aliases for SYT13 gene to outside databases

Previous GC identifers: GC11M047006 GC11P045773 GC11M045293 GC11M045226 GC11M045218 GC11M044971


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYT13 Gene:
This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular
N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B).
Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different
biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function
as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode
different protein isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SYT13 Gene: 
SYT13 (synaptotagmin XIII) is a protein-coding gene. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT13_HUMAN, Q7L8C5
Function: May be involved in transport vesicle docking to the plasma membrane (By similarity)

Gene Wiki entry for SYT13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT13 gene promoter:
         c-Fos   Max1   AP-1   LUN-1   Evi-1   GATA-1   Max   HOXA5   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT13 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p12-p11   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p12-p11

SYT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M045261:  view genomic region     (about GC identifiers)

Start:
45,261,852 bp from pter      End:
45,307,884 bp from pter
Size:
46,033 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYT13_HUMAN, Q7L8C5 (See protein sequence)
Recommended Name: Synaptotagmin-13  
Size: 426 amino acids; 46885 Da
Subunit: Interacts with NRXN1 (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (By similarity)
Sequence caution: Sequence=BAA92665.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SYT13:
1WFM (3D)    
Secondary accessions: A8K4P4 D3DQP1 Q9BQS3 Q9H041 Q9P2C0

Explore the universe of human proteins at neXtProt for SYT13: NX_Q7L8C5

Explore proteomics data for SYT13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L8C5

  • SYT13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYT13 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001234916.1  NP_065877.1  

    ENSEMBL proteins: 
     ENSP00000020926   ENSP00000434967   ENSP00000432975  

    Human Recombinant Protein Products for SYT13: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for SYT13 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0030133transport vesicle IDA--

    SYT13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR018029 C2_membr_targeting
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q7L8C5

    ProtoNet protein and cluster: Q7L8C5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT13_HUMAN, Q7L8C5
    Domain: The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity)
    Domain: The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present (By
    similarity)
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT13_HUMAN, Q7L8C5
    Function: May be involved in transport vesicle docking to the plasma membrane (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SYT13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SYT13:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYT13 
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    SwitchGear 3'UTR luciferase reporter plasmidSYT13 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYT13

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SYT13 (Q7L8C53 ENSP000000209264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1Q9ULB13, ENSP000003851424I2D: score=2 STRING: ENSP00000385142
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport IEA--

    SYT13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT13

    1 HMDB Compound for SYT13    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about SYT13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYT13 gene (2 alternative transcripts): 
    NM_001247987.1  NM_020826.2  

    Unigene Cluster for SYT13:

    Synaptotagmin XIII
    Hs.436643  [show with all ESTs]
    Unigene Representative Sequence: NM_001247987
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000020926(uc009yku.1 uc001myq.2) ENST00000533332 ENST00000528101

    miRNA
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    hsa-miR-1321 hsa-miR-640 hsa-miR-3616-5p hsa-miR-1224-3p hsa-miR-218 hsa-miR-650 hsa-miR-10b* hsa-miR-649
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    Additional mRNA sequence: 

    AB037848.1 AJ303362.1 AK291009.1 AK308841.1 AL512743.1 BC093830.1 BC093832.1 

    3 DOTS entries:

    DT.95165324  DT.92420257  DT.95301934 

    24/90 AceView cDNA sequences (see all 90):

    BM829236 AJ303362 AI267908 BX432020 BM839692 BE671015 BM127079 AA928902 
    F10796 BM759461 AL564852 CK818813 CR592126 CA423496 AL532730 AB037848 
    AW023391 BX478142 AW069785 CK818812 BI522800 AW498924 AA971413 BM709820 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SYT13    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -     -                                       
    SP2:              -                                                   
    SP3:                    -     -                                       


    ECgene alternative splicing isoforms for SYT13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT13 expression in normal human tissues (normalized intensities)      SYT13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACATTGTA
    SYT13 Expression
    About this image


    SYT13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 31 entries
             Thalamus
             postcentral gyrus   
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             sensory organ/ear/inner ear   

    See SYT13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT13

    SOURCE GeneReport for Unigene cluster: Hs.436643

    UniProtKB/Swiss-Prot: SYT13_HUMAN, Q7L8C5
    Tissue specificity: Expressed in brain, pancreas and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SYT13 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt131 , 5 synaptotagmin XIII1, 5 87.17(n)1
    89.91(a)1
      2 (51.37 cM)5
    809761  NM_030725.41  NP_109650.11 
     929150985 
    chicken
    (Gallus gallus)
    Aves SYT136
    synaptotagmin-13
    67(a)
    1 ↔ 1
    5(21620328-21632900)
    lizard
    (Anolis carolinensis)
    Reptilia SYT136
    --
    (see all 3)
    --
    62(a)
    21(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    1(46870285-46916627)
    1(74995175-75013783)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.172532 Transcribed sequence with weak similarity to protein more 77.82(n)    BM023677.1 


    ENSEMBL Gene Tree for SYT13 (if available)
    TreeFam Gene Tree for SYT13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT13 gene
    SYT152  

    SYT13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1032 SNPs in SYT13 are shown (see all 1032)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1160008871,2
    F--45261360(+) TCACAC/TAAGCG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs587118891,2
    C--45261415(+) ACAGT-/AAAAAA 2 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1932076301,2
    --45261446(+) ATGTAA/GATATA 2 -- int10--------
    rs1393481381,2
    --45261459(+) TCAACC/TGCATA 2 -- int10--------
    rs1845722661,2
    --45261500(+) CATACA/GTCAGT 2 -- int10--------
    rs576102431,2
    --45261523(+) AACTGC/GAGCTG 2 -- int10--------
    rs1892371821,2
    --45261609(+) AAAACA/CCTTTA 2 -- int10--------
    rs1450410271,2
    C--45261824(+) TAAAAC/TGGAAA 2 -- int10--------
    rs1491139911,2
    --45261855(+) TGACCC/TTGTTG 2 -- ut310--------
    rs1430098291,2
    C--45261857(+) ACCCTA/GTTGGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT13 (45261852 - 45307884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYT13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv305CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SYT13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SYT13 for disorders           About MalaCards
    OMIM gene information: 607716    OMIM disorders: --


    SYT13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYT13
    Human Genome Epidemiology (HuGE) Navigator: SYT13 (1 document)

    Export disorders for SYT13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT13 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SYT13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII). (PubMed id 11171101)1, 3, 9 Fukuda M. and Mikoshiba K. (2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 2 Craxton M.A. (2001)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. Re-expression of tumorigenicity after attenuation of human synaptotagmin 13 in a suppressed microcell hybrid cell line. (PubMed id 18202767)1, 9 Jahn J.E. and Coleman W.B. (2008)
    7. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    8. Exogenous expression of synaptotagmin XIII suppresses the neoplastic phenotype of a rat liver tumor cell line through molecular path ways related to mesenchymal to epithelial transition. (PubMed id 20840848)1 Jahn J.E....Coleman W.B. (2010)
    9. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57586 HGNC: 14962 AceView: SYT13 Ensembl:ENSG00000019505 euGenes: HUgn57586
    ECgene: SYT13 H-InvDB: SYT13

    (According to HUGE)
    About This Section
    HUGE: KIAA1427

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYT13 gene:
    Search GeneIP for patents involving SYT13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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