Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYT12 Gene

Aliases for SYT12 Gene

  • Synaptotagmin 12 2 3 5
  • Synaptotagmin XII 2 4
  • SytXII 3 4
  • Synaptotagmin-XII 3
  • Synaptotagmin-12 3
  • SYT11 3

External Ids for SYT12 Gene

Previous GeneCards Identifiers for SYT12 Gene

  • GC11P069308
  • GC11P068455
  • GC11P066549
  • GC11P066566
  • GC11P066530
  • GC11P066791
  • GC11P063117

Summaries for SYT12 Gene

Entrez Gene Summary for SYT12 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]

GeneCards Summary for SYT12 Gene

SYT12 (Synaptotagmin 12) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot for SYT12 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT12 Gene

Genomics for SYT12 Gene

Regulatory Elements for SYT12 Gene

Enhancers for SYT12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F066949 1.7 FANTOM5 Ensembl ENCODE 11.6 -55.1 -55086 4.3 HDGF PKNOX1 ARID4B SIN3A YY1 ZNF207 FOS DEK ZNF263 SP3 ACTN3 RBM14 ENSG00000258297 LOC105369353 LOC105369352 ENSG00000255038 FAM86C2P RCE1 SYT12 CCS
GH11F066891 1.6 FANTOM5 Ensembl ENCODE 11.1 -114.2 -114182 1.8 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 SLC30A9 FOS JUNB REST LOC105369353 RAD9A LRFN4 RBM4B RNU7-23P SYT12 ACTN3 CDK2AP2 CLCF1 RBM4
GH11F066933 1.3 Ensembl ENCODE 11.2 -71.3 -71315 4.6 PKNOX1 ATF1 ARNT BRCA1 GATA2 ELK1 FOS KDM4B NCOA1 REST RAD9A PC SYT12 LRFN4 RHOD LOC101928069 ACTN3 EIF1AD MIR3163 LOC105369355
GH11F066903 1.2 Ensembl ENCODE 10.7 -100.1 -100141 5.6 ARID4B DMAP1 YY1 FOS SP5 NFYC PPARG ZNF623 MAFF ZSCAN16 PC C11orf80 RHOD ACTN3 CTSF RIN1 C11orf86 LRFN4 SYT12 LOC100505504
GH11F067081 1.1 Ensembl ENCODE 10.8 +75.3 75320 1.4 ARID4B BRCA1 RAD21 RFX5 ZNF143 THAP11 SMARCA5 ZNF654 CEBPB ZHX2 KDM2A SYT12 RNU7-23P GC11P067094 RHOD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYT12 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT12 Gene

Chromosome:
11
Start:
67,006,773 bp from pter
End:
67,050,863 bp from pter
Size:
44,091 bases
Orientation:
Plus strand

Genomic View for SYT12 Gene

Genes around SYT12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT12 Gene

Proteins for SYT12 Gene

  • Protein details for SYT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV01-SYT12_HUMAN
    Recommended name:
    Synaptotagmin-12
    Protein Accession:
    Q8IV01

    Protein attributes for SYT12 Gene

    Size:
    421 amino acids
    Molecular mass:
    46537 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).

neXtProt entry for SYT12 Gene

Post-translational modifications for SYT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT12 Gene

Domains & Families for SYT12 Gene

Gene Families for SYT12 Gene

Protein Domains for SYT12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV01

UniProtKB/Swiss-Prot:

SYT12_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT12: view

Function for SYT12 Gene

Molecular function for SYT12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT12: view
genes like me logo Genes that share phenotypes with SYT12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SYT12

miRNA for SYT12 Gene

miRTarBase miRNAs that target SYT12

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT12 Gene

Localization for SYT12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT12 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT12 gene
Compartment Confidence
plasma membrane 4
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA,IBA --
genes like me logo Genes that share ontologies with SYT12: view

Pathways & Interactions for SYT12 Gene

genes like me logo Genes that share pathways with SYT12: view

Pathways by source for SYT12 Gene

Interacting Proteins for SYT12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000377520%0d%0a9606.ENSP00000083182%0d%0a9606.ENSP00000327214%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8IV01-SYT12_HUMAN ENSP00000377520 for SYT12 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0046928 regulation of neurotransmitter secretion IEA --
GO:0048488 synaptic vesicle endocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT12: view

No data available for SIGNOR curated interactions for SYT12 Gene

Transcripts for SYT12 Gene

Unigene Clusters for SYT12 Gene

Synaptotagmin XII:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - -

Relevant External Links for SYT12 Gene

GeneLoc Exon Structure for
SYT12
ECgene alternative splicing isoforms for
SYT12

Expression for SYT12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT12 Gene

mRNA differential expression in normal tissues according to GTEx for SYT12 Gene

This gene is overexpressed in Brain - Cerebellum (x7.8), Brain - Cerebellar Hemisphere (x7.4), Brain - Cortex (x4.9), and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for SYT12 Gene

This gene is overexpressed in Frontal cortex (36.7) and Cervix (32.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYT12 Gene



Protein tissue co-expression partners for SYT12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYT12 Gene:

SYT12

SOURCE GeneReport for Unigene cluster for SYT12 Gene:

Hs.287636
genes like me logo Genes that share expression patterns with SYT12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SYT12 Gene

Orthologs for SYT12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT12 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia SYT12 34 35
  • 90.89 (n)
cow
(Bos Taurus)
Mammalia SYT12 34 35
  • 90.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SYT12 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt12 34
  • 88.12 (n)
mouse
(Mus musculus)
Mammalia Syt12 34 16 35
  • 87.97 (n)
oppossum
(Monodelphis domestica)
Mammalia SYT12 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT12 34 35
  • 76.38 (n)
lizard
(Anolis carolinensis)
Reptilia SYT12 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt12 34
  • 68.56 (n)
zebrafish
(Danio rerio)
Actinopterygii syt12 34 35
  • 68.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta Syt12 35
  • 16 (a)
OneToOne
Species where no ortholog for SYT12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT12 Gene

ENSEMBL:
Gene Tree for SYT12 (if available)
TreeFam:
Gene Tree for SYT12 (if available)

Paralogs for SYT12 Gene

Paralogs for SYT12 Gene

(6) SIMAP similar genes for SYT12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT12: view

Variants for SYT12 Gene

Sequence variations from dbSNP and Humsavar for SYT12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10160663 -- 67,033,776(+) TCCTT(G/T)GGGGA intron-variant
rs10661797 -- 67,013,575(+) TGGCC(-/CTGT)CACAA intron-variant
rs10750792 -- 67,035,347(+) TTTTT(C/T)CAAAA intron-variant
rs10750793 -- 67,038,918(+) GGAGG(C/G)AGAGG intron-variant
rs10791898 -- 67,040,842(+) CAAAA(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT12 Gene

Variant ID Type Subtype PubMed ID
nsv832194 CNV gain+loss 17160897
nsv555226 CNV gain 21841781
nsv1134147 CNV deletion 24896259
dgv1973n54 CNV loss 21841781

Variation tolerance for SYT12 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT12 Gene

Disorders for SYT12 Gene

Relevant External Links for SYT12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT12

No disorders were found for SYT12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT12 Gene

Publications for SYT12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 64
  5. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. (PMID: 17190793) Maximov A. … SA1dhof T.C. (J. Cell Biol. 2007) 3 64

Products for SYT12 Gene

Sources for SYT12 Gene

Content
Loading form....