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Aliases for SYT12 Gene

Aliases for SYT12 Gene

  • Synaptotagmin XII 2 3 4
  • SytXII 3 4
  • Synaptotagmin-XII 3
  • Synaptotagmin-12 3
  • SYT11 3
  • SRG1 6

External Ids for SYT12 Gene

Summaries for SYT12 Gene

Entrez Gene Summary for SYT12 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]

GeneCards Summary for SYT12 Gene

SYT12 (Synaptotagmin XII) is a Protein Coding gene. Among its related pathways are Parkinsons Disease Pathway and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT12 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT12 Gene

Genomics for SYT12 Gene

Genomic Location for SYT12 Gene

Start:
67,006,778 bp from pter
End:
67,050,863 bp from pter
Size:
44,086 bases
Orientation:
Plus strand

Genomic View for SYT12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT12 Gene

Regulatory Elements for SYT12 Gene

Proteins for SYT12 Gene

  • Protein details for SYT12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV01-SYT12_HUMAN
    Recommended name:
    Synaptotagmin-12
    Protein Accession:
    Q8IV01
    Secondary Accessions:

    Protein attributes for SYT12 Gene

    Size:
    421 amino acids
    Molecular mass:
    46537 Da
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity).

neXtProt entry for SYT12 Gene

Proteomics data for SYT12 Gene at MOPED

Post-translational modifications for SYT12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT12 Gene

No data available for DME Specific Peptides for SYT12 Gene

Domains for SYT12 Gene

Gene Families for SYT12 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SYT12_HUMAN
Domain:
  • Contains 2 C2 domains.:
    • Q8IV01
Family:
  • Belongs to the synaptotagmin family.:
    • Q8IV01
genes like me logo Genes that share domains with SYT12: view

Function for SYT12 Gene

Molecular function for SYT12 Gene

UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT12: view

Phenotypes for SYT12 Gene

MGI mutant phenotypes for SYT12:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYT12:
genes like me logo Genes that share phenotypes with SYT12: view

miRNA for SYT12 Gene

miRTarBase miRNAs that target SYT12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYT12 Gene

Localization for SYT12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT12 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT12 Gene COMPARTMENTS Subcellular localization image for SYT12 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with SYT12: view

Pathways for SYT12 Gene

genes like me logo Genes that share pathways with SYT12: view

Pathways by source for SYT12 Gene

1 Qiagen pathway for SYT12 Gene
1 BioSystems pathway for SYT12 Gene

Interacting Proteins for SYT12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000377520%0d%0a9606.ENSP00000083182%0d%0a9606.ENSP00000327214%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000377520 for SYT12 Gene via STRING

Gene Ontology (GO) - Biological Process for SYT12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0046928 regulation of neurotransmitter secretion IEA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT12: view

Transcripts for SYT12 Gene

Unigene Clusters for SYT12 Gene

Synaptotagmin XII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - - -

Relevant External Links for SYT12 Gene

GeneLoc Exon Structure for
SYT12
ECgene alternative splicing isoforms for
SYT12

Expression for SYT12 Gene

mRNA expression in normal human tissues for SYT12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT12 Gene

This gene is overexpressed in Brain - Cerebellum (7.8), Brain - Cerebellar Hemisphere (7.4), Brain - Cortex (4.9), and Brain - Frontal Cortex (BA9) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYT12 Gene

SOURCE GeneReport for Unigene cluster for SYT12 Gene Hs.287636

genes like me logo Genes that share expressions with SYT12: view

Orthologs for SYT12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT12 36
  • 99.27 (n)
  • 99.51 (a)
SYT12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT12 36
  • 90.82 (n)
  • 96.44 (a)
SYT12 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT12 36
  • 90.89 (n)
  • 95.25 (a)
SYT12 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt12 36
  • 87.97 (n)
  • 95.01 (a)
Syt12 16
Syt12 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT12 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT12 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt12 36
  • 88.12 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves SYT12 36
  • 76.38 (n)
  • 76.21 (a)
SYT12 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT12 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt12 36
  • 68.56 (n)
  • 72.59 (a)
zebrafish
(Danio rerio)
Actinopterygii syt12 36
  • 68.04 (n)
  • 67.55 (a)
syt12 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syt12 37
  • 16 (a)
OneToOne
Species with no ortholog for SYT12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYT12 Gene

ENSEMBL:
Gene Tree for SYT12 (if available)
TreeFam:
Gene Tree for SYT12 (if available)

Paralogs for SYT12 Gene

Paralogs for SYT12 Gene

Selected SIMAP similar genes for SYT12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT12: view

Variants for SYT12 Gene

Sequence variations from dbSNP and Humsavar for SYT12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1270998 -- 67,032,916(-) ttttt(A/T)ttttt intron-variant
rs1892928 -- 67,026,637(+) AACTC(C/T)CCCCG intron-variant
rs2260587 -- 67,036,341(-) TATCA(C/T)GACAT intron-variant
rs2443622 -- 67,037,837(+) AGATC(A/G)CACCA intron-variant
rs2508605 -- 67,037,839(+) ATCGC(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT12 Gene

Variant ID Type Subtype PubMed ID
nsv832194 CNV Gain+Loss 17160897

Relevant External Links for SYT12 Gene

HapMap Linkage Disequilibrium report
SYT12

Disorders for SYT12 Gene

No disorders were found for SYT12 Gene.

No data available for UniProtKB/Swiss-Prot for SYT12 Gene

Publications for SYT12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. (PMID: 17190793) Maximov A. … SA1dhof T.C. (J. Cell Biol. 2007) 3
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for SYT12 Gene

Sources for SYT12 Gene

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